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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCALD-UBR5 (FusionGDB2 ID:57504)

Fusion Gene Summary for NCALD-UBR5

check button Fusion gene summary
Fusion gene informationFusion gene name: NCALD-UBR5
Fusion gene ID: 57504
HgeneTgene
Gene symbol

NCALD

UBR5

Gene ID

83988

51366

Gene nameneurocalcin deltaubiquitin protein ligase E3 component n-recognin 5
Synonyms-DD5|EDD|EDD1|HYD
Cytomap

8q22.3

8q22.3

Type of geneprotein-codingprotein-coding
Descriptionneurocalcin-deltaE3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein
Modification date2020031320200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000220931, ENST00000311028, 
ENST00000395923, ENST00000519508, 
ENST00000521599, ENST00000522951, 
ENST00000521371, 		ENST00000519528, 
ENST00000220959, ENST00000518205, 
ENST00000520539, ENST00000521922, 
Fusion gene scores* DoF score9 X 9 X 9=72914 X 17 X 10=2380
# samples 1419
** MAII scorelog2(14/729*10)=-2.38049198738197
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/2380*10)=-3.64689024986436
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCALD [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCALD(103032465)-UBR5(103317523), # samples:2
NCALD(103032465)-UBR5(103373854), # samples:2
NCALD(102731480)-UBR5(103266742), # samples:2
Anticipated loss of major functional domain due to fusion event.NCALD-UBR5 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NCALD-UBR5 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NCALD-UBR5 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NCALD-UBR5 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUBR5

GO:0000209

protein polyubiquitination

21118991|28689657

TgeneUBR5

GO:0006974

cellular response to DNA damage stimulus

12011095

TgeneUBR5

GO:0010628

positive regulation of gene expression

18076571

TgeneUBR5

GO:0050847

progesterone receptor signaling pathway

12011095

TgeneUBR5

GO:0070936

protein K48-linked ubiquitination

28689657


check buttonFusion gene breakpoints across NCALD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UBR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A9V0-01ANCALDchr8

103032465

-UBR5chr8

103317523

-
ChimerDB4UCECTCGA-A5-A7WK-01ANCALDchr8

103136465

-UBR5chr8

103279235

-
ChimerDB4UCECTCGA-BK-A0CA-01ANCALDchr8

103032465

-UBR5chr8

103373854

-
ChimerDB4UCECTCGA-BK-A0CA-01BNCALDchr8

103032465

-UBR5chr8

103373854

-
ChimerDB4UCECTCGA-PG-A914-01ANCALDchr8

102731480

-UBR5chr8

103266742

-


Top

Fusion Gene ORF analysis for NCALD-UBR5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000220931ENST00000519528NCALDchr8

102731480

-UBR5chr8

103266742

-
5CDS-intronENST00000311028ENST00000519528NCALDchr8

102731480

-UBR5chr8

103266742

-
5CDS-intronENST00000395923ENST00000519528NCALDchr8

102731480

-UBR5chr8

103266742

-
5CDS-intronENST00000519508ENST00000519528NCALDchr8

102731480

-UBR5chr8

103266742

-
5CDS-intronENST00000521599ENST00000519528NCALDchr8

102731480

-UBR5chr8

103266742

-
5CDS-intronENST00000522951ENST00000519528NCALDchr8

102731480

-UBR5chr8

103266742

-
5UTR-3CDSENST00000311028ENST00000220959NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-3CDSENST00000311028ENST00000220959NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-3CDSENST00000311028ENST00000220959NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-3CDSENST00000311028ENST00000518205NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-3CDSENST00000311028ENST00000520539NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-3CDSENST00000311028ENST00000520539NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-3CDSENST00000311028ENST00000520539NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-3CDSENST00000311028ENST00000521922NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-3CDSENST00000395923ENST00000220959NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-3CDSENST00000395923ENST00000220959NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-3CDSENST00000395923ENST00000520539NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-3CDSENST00000395923ENST00000520539NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-3CDSENST00000521599ENST00000220959NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-3CDSENST00000521599ENST00000220959NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-3CDSENST00000521599ENST00000220959NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-3CDSENST00000521599ENST00000518205NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-3CDSENST00000521599ENST00000520539NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-3CDSENST00000521599ENST00000520539NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-3CDSENST00000521599ENST00000520539NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-3CDSENST00000521599ENST00000521922NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-intronENST00000311028ENST00000518205NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000311028ENST00000518205NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-intronENST00000311028ENST00000519528NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000311028ENST00000519528NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-intronENST00000311028ENST00000519528NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-intronENST00000311028ENST00000521922NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000311028ENST00000521922NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-intronENST00000395923ENST00000518205NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000395923ENST00000518205NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-intronENST00000395923ENST00000519528NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000395923ENST00000519528NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-intronENST00000395923ENST00000521922NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000395923ENST00000521922NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-intronENST00000521599ENST00000518205NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000521599ENST00000518205NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-intronENST00000521599ENST00000519528NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000521599ENST00000519528NCALDchr8

103136465

-UBR5chr8

103279235

-
5UTR-intronENST00000521599ENST00000519528NCALDchr8

103032465

-UBR5chr8

103373854

-
5UTR-intronENST00000521599ENST00000521922NCALDchr8

103032465

-UBR5chr8

103317523

-
5UTR-intronENST00000521599ENST00000521922NCALDchr8

103032465

-UBR5chr8

103373854

-
Frame-shiftENST00000220931ENST00000220959NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000220931ENST00000518205NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000220931ENST00000521922NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000311028ENST00000220959NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000311028ENST00000518205NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000311028ENST00000520539NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000395923ENST00000220959NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000395923ENST00000518205NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000395923ENST00000520539NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000519508ENST00000520539NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000519508ENST00000521922NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000521599ENST00000220959NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000521599ENST00000518205NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000521599ENST00000520539NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000522951ENST00000220959NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000522951ENST00000518205NCALDchr8

102731480

-UBR5chr8

103266742

-
Frame-shiftENST00000522951ENST00000521922NCALDchr8

102731480

-UBR5chr8

103266742

-
In-frameENST00000220931ENST00000520539NCALDchr8

102731480

-UBR5chr8

103266742

-
In-frameENST00000311028ENST00000521922NCALDchr8

102731480

-UBR5chr8

103266742

-
In-frameENST00000395923ENST00000521922NCALDchr8

102731480

-UBR5chr8

103266742

-
In-frameENST00000519508ENST00000220959NCALDchr8

102731480

-UBR5chr8

103266742

-
In-frameENST00000519508ENST00000518205NCALDchr8

102731480

-UBR5chr8

103266742

-
In-frameENST00000521599ENST00000521922NCALDchr8

102731480

-UBR5chr8

103266742

-
In-frameENST00000522951ENST00000520539NCALDchr8

102731480

-UBR5chr8

103266742

-
intron-3CDSENST00000220931ENST00000220959NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-3CDSENST00000220931ENST00000220959NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000220931ENST00000220959NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-3CDSENST00000220931ENST00000518205NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000220931ENST00000520539NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-3CDSENST00000220931ENST00000520539NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000220931ENST00000520539NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-3CDSENST00000220931ENST00000521922NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000395923ENST00000220959NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000395923ENST00000518205NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000395923ENST00000520539NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000395923ENST00000521922NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000519508ENST00000220959NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-3CDSENST00000519508ENST00000220959NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000519508ENST00000220959NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-3CDSENST00000519508ENST00000518205NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000519508ENST00000520539NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-3CDSENST00000519508ENST00000520539NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000519508ENST00000520539NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-3CDSENST00000519508ENST00000521922NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000521371ENST00000220959NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-3CDSENST00000521371ENST00000220959NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000521371ENST00000220959NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-3CDSENST00000521371ENST00000220959NCALDchr8

102731480

-UBR5chr8

103266742

-
intron-3CDSENST00000521371ENST00000518205NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000521371ENST00000518205NCALDchr8

102731480

-UBR5chr8

103266742

-
intron-3CDSENST00000521371ENST00000520539NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-3CDSENST00000521371ENST00000520539NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000521371ENST00000520539NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-3CDSENST00000521371ENST00000520539NCALDchr8

102731480

-UBR5chr8

103266742

-
intron-3CDSENST00000521371ENST00000521922NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000521371ENST00000521922NCALDchr8

102731480

-UBR5chr8

103266742

-
intron-3CDSENST00000522951ENST00000220959NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-3CDSENST00000522951ENST00000220959NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000522951ENST00000220959NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-3CDSENST00000522951ENST00000518205NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000522951ENST00000520539NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-3CDSENST00000522951ENST00000520539NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-3CDSENST00000522951ENST00000520539NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-3CDSENST00000522951ENST00000521922NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-intronENST00000220931ENST00000518205NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000220931ENST00000518205NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000220931ENST00000519528NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000220931ENST00000519528NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-intronENST00000220931ENST00000519528NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000220931ENST00000521922NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000220931ENST00000521922NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000395923ENST00000519528NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-intronENST00000519508ENST00000518205NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000519508ENST00000518205NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000519508ENST00000519528NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000519508ENST00000519528NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-intronENST00000519508ENST00000519528NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000519508ENST00000521922NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000519508ENST00000521922NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000521371ENST00000518205NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000521371ENST00000518205NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000521371ENST00000519528NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000521371ENST00000519528NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-intronENST00000521371ENST00000519528NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000521371ENST00000519528NCALDchr8

102731480

-UBR5chr8

103266742

-
intron-intronENST00000521371ENST00000521922NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000521371ENST00000521922NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000522951ENST00000518205NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000522951ENST00000518205NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000522951ENST00000519528NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000522951ENST00000519528NCALDchr8

103136465

-UBR5chr8

103279235

-
intron-intronENST00000522951ENST00000519528NCALDchr8

103032465

-UBR5chr8

103373854

-
intron-intronENST00000522951ENST00000521922NCALDchr8

103032465

-UBR5chr8

103317523

-
intron-intronENST00000522951ENST00000521922NCALDchr8

103032465

-UBR5chr8

103373854

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311028NCALDchr8102731480-ENST00000521922UBR5chr8103266742-1074757379969196
ENST00000395923NCALDchr8102731480-ENST00000521922UBR5chr8103266742-11558384601050196
ENST00000220931NCALDchr8102731480-ENST00000520539UBR5chr8103266742-2000497119709196
ENST00000521599NCALDchr8102731480-ENST00000521922UBR5chr8103266742-988671293883196
ENST00000522951NCALDchr8102731480-ENST00000520539UBR5chr8103266742-2016513135725196
ENST00000519508NCALDchr8102731480-ENST00000220959UBR5chr8103266742-117639719609196
ENST00000519508NCALDchr8102731480-ENST00000518205UBR5chr8103266742-71439719609196

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311028ENST00000521922NCALDchr8102731480-UBR5chr8103266742-0.0024681110.9975319
ENST00000395923ENST00000521922NCALDchr8102731480-UBR5chr8103266742-0.0061627420.9938373
ENST00000220931ENST00000520539NCALDchr8102731480-UBR5chr8103266742-0.0018428860.9981571
ENST00000521599ENST00000521922NCALDchr8102731480-UBR5chr8103266742-0.0022406630.99775934
ENST00000522951ENST00000520539NCALDchr8102731480-UBR5chr8103266742-0.0017405630.9982595
ENST00000519508ENST00000220959NCALDchr8102731480-UBR5chr8103266742-0.0019897090.99801034
ENST00000519508ENST00000518205NCALDchr8102731480-UBR5chr8103266742-0.0025932230.9974068

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Fusion Genomic Features for NCALD-UBR5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCALD-UBR5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:103032465/chr8:103317523)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCALDchr8:102731480chr8:103266742ENST00000220931-24109_120126194.0Calcium binding2
HgeneNCALDchr8:102731480chr8:103266742ENST00000220931-2473_84126194.0Calcium binding1
HgeneNCALDchr8:102731480chr8:103266742ENST00000311028-57109_120126194.0Calcium binding2
HgeneNCALDchr8:102731480chr8:103266742ENST00000311028-5773_84126194.0Calcium binding1
HgeneNCALDchr8:102731480chr8:103266742ENST00000395923-46109_120126194.0Calcium binding2
HgeneNCALDchr8:102731480chr8:103266742ENST00000395923-4673_84126194.0Calcium binding1
HgeneNCALDchr8:102731480chr8:103266742ENST00000519508-13109_120126194.0Calcium binding2
HgeneNCALDchr8:102731480chr8:103266742ENST00000519508-1373_84126194.0Calcium binding1
HgeneNCALDchr8:102731480chr8:103266742ENST00000521599-57109_120126194.0Calcium binding2
HgeneNCALDchr8:102731480chr8:103266742ENST00000521599-5773_84126194.0Calcium binding1
HgeneNCALDchr8:102731480chr8:103266742ENST00000220931-2423_58126194.0DomainEF-hand 1
HgeneNCALDchr8:102731480chr8:103266742ENST00000220931-2460_95126194.0DomainEF-hand 2
HgeneNCALDchr8:102731480chr8:103266742ENST00000311028-5723_58126194.0DomainEF-hand 1
HgeneNCALDchr8:102731480chr8:103266742ENST00000311028-5760_95126194.0DomainEF-hand 2
HgeneNCALDchr8:102731480chr8:103266742ENST00000395923-4623_58126194.0DomainEF-hand 1
HgeneNCALDchr8:102731480chr8:103266742ENST00000395923-4660_95126194.0DomainEF-hand 2
HgeneNCALDchr8:102731480chr8:103266742ENST00000519508-1323_58126194.0DomainEF-hand 1
HgeneNCALDchr8:102731480chr8:103266742ENST00000519508-1360_95126194.0DomainEF-hand 2
HgeneNCALDchr8:102731480chr8:103266742ENST00000521599-5723_58126194.0DomainEF-hand 1
HgeneNCALDchr8:102731480chr8:103266742ENST00000521599-5760_95126194.0DomainEF-hand 2
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957592737_275727292800.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCALDchr8:102731480chr8:103266742ENST00000220931-24157_168126194.0Calcium binding3
HgeneNCALDchr8:102731480chr8:103266742ENST00000311028-57157_168126194.0Calcium binding3
HgeneNCALDchr8:102731480chr8:103266742ENST00000395923-46157_168126194.0Calcium binding3
HgeneNCALDchr8:102731480chr8:103266742ENST00000519508-13157_168126194.0Calcium binding3
HgeneNCALDchr8:102731480chr8:103266742ENST00000521599-57157_168126194.0Calcium binding3
HgeneNCALDchr8:102731480chr8:103266742ENST00000220931-24144_179126194.0DomainEF-hand 4
HgeneNCALDchr8:102731480chr8:103266742ENST00000220931-2496_131126194.0DomainEF-hand 3
HgeneNCALDchr8:102731480chr8:103266742ENST00000311028-57144_179126194.0DomainEF-hand 4
HgeneNCALDchr8:102731480chr8:103266742ENST00000311028-5796_131126194.0DomainEF-hand 3
HgeneNCALDchr8:102731480chr8:103266742ENST00000395923-46144_179126194.0DomainEF-hand 4
HgeneNCALDchr8:102731480chr8:103266742ENST00000395923-4696_131126194.0DomainEF-hand 3
HgeneNCALDchr8:102731480chr8:103266742ENST00000519508-13144_179126194.0DomainEF-hand 4
HgeneNCALDchr8:102731480chr8:103266742ENST00000519508-1396_131126194.0DomainEF-hand 3
HgeneNCALDchr8:102731480chr8:103266742ENST00000521599-57144_179126194.0DomainEF-hand 4
HgeneNCALDchr8:102731480chr8:103266742ENST00000521599-5796_131126194.0DomainEF-hand 3
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957591528_153727292800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957591671_168127292800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957591762_176827292800.0Compositional biasNote=Poly-Ala
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957591986_199727292800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957592036_205927292800.0Compositional biasNote=Pro-rich
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957592329_234827292800.0Compositional biasNote=Arg/Glu-rich (mixed charge)
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957592357_236627292800.0Compositional biasNote=Arg/Asp-rich (mixed charge)
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957592489_250027292800.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneUBR5chr8:102731480chr8:103266742ENST000005205395759940_94527292800.0Compositional biasNote=Poly-Glu
TgeneUBR5chr8:102731480chr8:103266742ENST000005205395759980_98527292800.0Compositional biasNote=Poly-Ser
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957592377_245427292800.0DomainPABC
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957592462_279927292800.0DomainHECT
TgeneUBR5chr8:102731480chr8:103266742ENST0000052053957591177_124527292800.0Zinc fingerUBR-type


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Fusion Gene Sequence for NCALD-UBR5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57504_57504_1_NCALD-UBR5_NCALD_chr8_102731480_ENST00000220931_UBR5_chr8_103266742_ENST00000520539_length(transcript)=2000nt_BP=497nt
GTGAGAATCTGGTGGATGCTGGACCTTGCTGCTGCTGCTACTGCTGTTTCCAGGGGCTGCAGAGCATGGACTGTTAAATCTTGCACTTCT
TCTGAGTGAGCTGAATTCTTGCCGCCAGGATGGGGAAACAGAACAGCAAGCTGCGCCCGGAGGTCATGCAGGACTTGCTGGAAAGCACAG
ACTTTACAGAGCATGAGATCCAGGAATGGTATAAAGGCTTCTTGAGAGACTGCCCCAGTGGACATTTGTCAATGGAAGAGTTTAAGAAAA
TATATGGGAACTTTTTCCCTTATGGGGATGCTTCCAAATTTGCAGAGCATGTCTTCCGCACCTTCGATGCAAATGGAGATGGGACAATAG
ACTTTAGAGAATTCATCATCGCCTTGAGTGTAACTTCGAGGGGGAAGCTGGAGCAGAAGCTGAAATGGGCCTTCAGCATGTACGACCTGG
ACGGAAATGGCTATATCAGCAAGGCAGAGATGCTAGAGATCGTGCAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAG
AAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACG
TCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAA
GTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACC
CCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCT
ATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTT
GCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAG
GGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTA
TCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGG
TTTGACTGCATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAGGGCACTTTTTTTGTAC
ATATGATGGGGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTCAGTCTCAAGAGGTTAC
TGCACTTCAGTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGATAACTGTAAAATGTTTT
ATAAGATCATGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATCTAGCCTTTTTTAAGTA
TCTTGTTACATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTTTTATTTATGTAGTTGT
ACATTTTTAAACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTTATATACACCTGGACTA
TAAGAAACAGAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTTTTCATTTTACAAATGG
GGGAAGTGAAGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTGATGACCTATTAATTAT

>57504_57504_1_NCALD-UBR5_NCALD_chr8_102731480_ENST00000220931_UBR5_chr8_103266742_ENST00000520539_length(amino acids)=196AA_BP=124
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALS
VTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQIL

--------------------------------------------------------------
>57504_57504_2_NCALD-UBR5_NCALD_chr8_102731480_ENST00000311028_UBR5_chr8_103266742_ENST00000521922_length(transcript)=1074nt_BP=757nt
GACGGTGCTGTCCAGGGGGAGGCGGGCGGAGGGAAGGCGCTGCCGCTGCTGCCGCCGCCTCGCCCGAAGCGACACAGACGCTGGGAGCGG
CCGAGGCGAGATGTATTTAGACTTTTTAATTATTCTTCCTAGTTCCTGATAAGCTAAGACAATACTTTTATTTTTGACAGAGTGATTTCT
TCTGACTTGAGCCTGCAGTGTGCTGTGAGAGATCTACCACTAGATTATCTCAACTTTGGTCTCCTGGGACCACTCGTTGCTGACAGTCAG
AAATTGCAAGGCATCTGATCTCCTGGTGTTAAAATCTGTCGTGATACCGAGGAAGGCCCCGAGATCCCAGGCACTGAGTGACTGCATACT
CTGAATTCTTGCCGCCAGGATGGGGAAACAGAACAGCAAGCTGCGCCCGGAGGTCATGCAGGACTTGCTGGAAAGCACAGACTTTACAGA
GCATGAGATCCAGGAATGGTATAAAGGCTTCTTGAGAGACTGCCCCAGTGGACATTTGTCAATGGAAGAGTTTAAGAAAATATATGGGAA
CTTTTTCCCTTATGGGGATGCTTCCAAATTTGCAGAGCATGTCTTCCGCACCTTCGATGCAAATGGAGATGGGACAATAGACTTTAGAGA
ATTCATCATCGCCTTGAGTGTAACTTCGAGGGGGAAGCTGGAGCAGAAGCTGAAATGGGCCTTCAGCATGTACGACCTGGACGGAAATGG
CTATATCAGCAAGGCAGAGATGCTAGAGATCGTGCAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCA
GCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTA
TTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTG

>57504_57504_2_NCALD-UBR5_NCALD_chr8_102731480_ENST00000311028_UBR5_chr8_103266742_ENST00000521922_length(amino acids)=196AA_BP=124
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALS
VTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQIL

--------------------------------------------------------------
>57504_57504_3_NCALD-UBR5_NCALD_chr8_102731480_ENST00000395923_UBR5_chr8_103266742_ENST00000521922_length(transcript)=1155nt_BP=838nt
AGGGGCCCCTTAGATGTCTTCCTCCGGATTTTTTGTTAAGCTTTTCCTAGACAGTTTACAGAAGGCTTTGGGTAGAGAAAGCACTAGTTA
GACAAAAGCAGCCCCCCTCCCACCTTGTGGGCATGAAGAGTCCAGAGGACACCACCTGAGAAGCTTTTCAACTGCCTTCCAAGGCTCCCT
TGAACTTCACTGCGGTAGAGCAGGGACCCCAGACCCCCCCTCAAATCGAAGCTTGGAAGGAGGTGCTCTAGGCTGAATCTGACCTCCCAG
GACCCGAGGAGGCAAGCAGATGGCACCCCTTGGAAAGTAGCAGTGCAGGCTGGCTAGAGGCCTGGGCGAGTGATTTCTTCTGACTTGAGC
CTGCAGTGTGCTGTGAGAGATCTACCACTAGATTATCTCAACTTTGGTCTCCTGGGACCACTCGTTGCTGACAGTCAGAAACTGAATTCT
TGCCGCCAGGATGGGGAAACAGAACAGCAAGCTGCGCCCGGAGGTCATGCAGGACTTGCTGGAAAGCACAGACTTTACAGAGCATGAGAT
CCAGGAATGGTATAAAGGCTTCTTGAGAGACTGCCCCAGTGGACATTTGTCAATGGAAGAGTTTAAGAAAATATATGGGAACTTTTTCCC
TTATGGGGATGCTTCCAAATTTGCAGAGCATGTCTTCCGCACCTTCGATGCAAATGGAGATGGGACAATAGACTTTAGAGAATTCATCAT
CGCCTTGAGTGTAACTTCGAGGGGGAAGCTGGAGCAGAAGCTGAAATGGGCCTTCAGCATGTACGACCTGGACGGAAATGGCTATATCAG
CAAGGCAGAGATGCTAGAGATCGTGCAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCC
CTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTATTCCTCTAA
ACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAAT

>57504_57504_3_NCALD-UBR5_NCALD_chr8_102731480_ENST00000395923_UBR5_chr8_103266742_ENST00000521922_length(amino acids)=196AA_BP=124
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALS
VTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQIL

--------------------------------------------------------------
>57504_57504_4_NCALD-UBR5_NCALD_chr8_102731480_ENST00000519508_UBR5_chr8_103266742_ENST00000220959_length(transcript)=1176nt_BP=397nt
CTGAATTCTTGCCGCCAGGATGGGGAAACAGAACAGCAAGCTGCGCCCGGAGGTCATGCAGGACTTGCTGGAAAGCACAGACTTTACAGA
GCATGAGATCCAGGAATGGTATAAAGGCTTCTTGAGAGACTGCCCCAGTGGACATTTGTCAATGGAAGAGTTTAAGAAAATATATGGGAA
CTTTTTCCCTTATGGGGATGCTTCCAAATTTGCAGAGCATGTCTTCCGCACCTTCGATGCAAATGGAGATGGGACAATAGACTTTAGAGA
ATTCATCATCGCCTTGAGTGTAACTTCGAGGGGGAAGCTGGAGCAGAAGCTGAAATGGGCCTTCAGCATGTACGACCTGGACGGAAATGG
CTATATCAGCAAGGCAGAGATGCTAGAGATCGTGCAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCA
GCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTA
TTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTG
CTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAGTTAATGCTGTCATACCCCCCTGGTGG
TACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCACTAGCAACATTTGGCTATATTGGTTT
GCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACACTGTGATTTATCTTTTTGCTGAGGGGG
AAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCTTGTATAGAGGGAATAGGGAATTTCAA
AATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGTTGGCTGCAACTGTGTATCATGTATAT
GGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAAACCACTTTTATTGCGGTTTGACTGCA

>57504_57504_4_NCALD-UBR5_NCALD_chr8_102731480_ENST00000519508_UBR5_chr8_103266742_ENST00000220959_length(amino acids)=196AA_BP=124
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALS
VTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQIL

--------------------------------------------------------------
>57504_57504_5_NCALD-UBR5_NCALD_chr8_102731480_ENST00000519508_UBR5_chr8_103266742_ENST00000518205_length(transcript)=714nt_BP=397nt
CTGAATTCTTGCCGCCAGGATGGGGAAACAGAACAGCAAGCTGCGCCCGGAGGTCATGCAGGACTTGCTGGAAAGCACAGACTTTACAGA
GCATGAGATCCAGGAATGGTATAAAGGCTTCTTGAGAGACTGCCCCAGTGGACATTTGTCAATGGAAGAGTTTAAGAAAATATATGGGAA
CTTTTTCCCTTATGGGGATGCTTCCAAATTTGCAGAGCATGTCTTCCGCACCTTCGATGCAAATGGAGATGGGACAATAGACTTTAGAGA
ATTCATCATCGCCTTGAGTGTAACTTCGAGGGGGAAGCTGGAGCAGAAGCTGAAATGGGCCTTCAGCATGTACGACCTGGACGGAAATGG
CTATATCAGCAAGGCAGAGATGCTAGAGATCGTGCAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGATTCCA
GCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCACTCTA
TTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGTATTG

>57504_57504_5_NCALD-UBR5_NCALD_chr8_102731480_ENST00000519508_UBR5_chr8_103266742_ENST00000518205_length(amino acids)=196AA_BP=124
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALS
VTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQIL

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>57504_57504_6_NCALD-UBR5_NCALD_chr8_102731480_ENST00000521599_UBR5_chr8_103266742_ENST00000521922_length(transcript)=988nt_BP=671nt
GGGGGAGGCGGGCGGAGGGAAGGCGCTGCCGCTGCTGCCGCCGCCTCGCCCGAAGCGACACAGACGCTGGGAGCGGCCGAGGCGAGATCC
TATCATTATTTTAAAATTCCTCCTCCTCCACGAAGTCCTTCCTGATTCCTTCAAAGAAATATCACTCCTCCGAATTCCCAGAGTGATTTC
TTCTGACTTGAGCCTGCAGTGTGCTGTGAGAGATCTACCACTAGATTATCTCAACTTTGGTCTCCTGGGACCACTCGTTGCTGACAGTCA
GAAACTGAATTCTTGCCGCCAGGATGGGGAAACAGAACAGCAAGCTGCGCCCGGAGGTCATGCAGGACTTGCTGGAAAGCACAGACTTTA
CAGAGCATGAGATCCAGGAATGGTATAAAGGCTTCTTGAGAGACTGCCCCAGTGGACATTTGTCAATGGAAGAGTTTAAGAAAATATATG
GGAACTTTTTCCCTTATGGGGATGCTTCCAAATTTGCAGAGCATGTCTTCCGCACCTTCGATGCAAATGGAGATGGGACAATAGACTTTA
GAGAATTCATCATCGCCTTGAGTGTAACTTCGAGGGGGAAGCTGGAGCAGAAGCTGAAATGGGCCTTCAGCATGTACGACCTGGACGGAA
ATGGCTATATCAGCAAGGCAGAGATGCTAGAGATCGTGCAGGTTTACTTTTGGACATCAAGCCCATCACTGCCAGCCAGTGAAGAAGGAT
TCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGCATTTCTCGACTTTACGTCCCAC
TCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTTGTGTAGAGTATAAAAAGTGTGT

>57504_57504_6_NCALD-UBR5_NCALD_chr8_102731480_ENST00000521599_UBR5_chr8_103266742_ENST00000521922_length(amino acids)=196AA_BP=124
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALS
VTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQIL

--------------------------------------------------------------
>57504_57504_7_NCALD-UBR5_NCALD_chr8_102731480_ENST00000522951_UBR5_chr8_103266742_ENST00000520539_length(transcript)=2016nt_BP=513nt
ACACAGTCAAAGGCTTGTGAGAATCTGGTGGATGCTGGACCTTGCTGCTGCTGCTACTGCTGTTTCCAGGGGCTGCAGAGCATGGACTGT
TAAATCTTGCACTTCTTCTGAGTGAGCTGAATTCTTGCCGCCAGGATGGGGAAACAGAACAGCAAGCTGCGCCCGGAGGTCATGCAGGAC
TTGCTGGAAAGCACAGACTTTACAGAGCATGAGATCCAGGAATGGTATAAAGGCTTCTTGAGAGACTGCCCCAGTGGACATTTGTCAATG
GAAGAGTTTAAGAAAATATATGGGAACTTTTTCCCTTATGGGGATGCTTCCAAATTTGCAGAGCATGTCTTCCGCACCTTCGATGCAAAT
GGAGATGGGACAATAGACTTTAGAGAATTCATCATCGCCTTGAGTGTAACTTCGAGGGGGAAGCTGGAGCAGAAGCTGAAATGGGCCTTC
AGCATGTACGACCTGGACGGAAATGGCTATATCAGCAAGGCAGAGATGCTAGAGATCGTGCAGGTTTACTTTTGGACATCAAGCCCATCA
CTGCCAGCCAGTGAAGAAGGATTCCAGCCTATGCCCTCAATCACAATAAGACCACCAGATGACCAACATCTTCCTACTGCAAATACTTGC
ATTTCTCGACTTTACGTCCCACTCTATTCCTCTAAACAGATTCTCAAACAGAAATTGTTACTCGCCATTAAGACCAAGAATTTTGGTTTT
GTGTAGAGTATAAAAAGTGTGTATTGCTGTGTAATATTACTAGCAAATTTTGTAGATTTTTTTCCATTTGTCTATAAAAGTTTATGGAAG
TTAATGCTGTCATACCCCCCTGGTGGTACCTTAAAGAGATAAAATGCAGACATTCCTTGCTGAGTTTATAGCTTAAAGGCCTAAGGAGCA
CTAGCAACATTTGGCTATATTGGTTTGCTAGTCACCAACTTCTGGGTCTAACCCCAGCCAAAGATGACAGCAGAACAACATAATTTACAC
TGTGATTTATCTTTTTGCTGAGGGGGAAAAAATGTAAATGTTCTGAAAATTCACTGCTGCCTTTGTGGAAACTGTTTCAGCAAAGGTTCT
TGTATAGAGGGAATAGGGAATTTCAAAATAAAAAATTAAGTATGTTCTGTGTTTTCATTTTAACTTTTTTTATGGTGTTTAATTTGTGGT
TGGCTGCAACTGTGTATCATGTATATGGAACTTGTAAAAAAGTTCTCGACATTCAGATCTTAAGAGATGAAATCACTTTTACCTATAAAA
ACCACTTTTATTGCGGTTTGACTGCATTGAGCTCTAGGATATTAAATGATATCACTAATATTTTGCATGTAATTTGCTCATTTGAGTGAG
GGCACTTTTTTTGTACATATGATGGGGCCAATGCACAATACTTTTATCACAATCAACTTTTTCTTTGTATCCCTATTTCAATGAGCAGTC
AGTCTCAAGAGGTTACTGCACTTCAGTTCTAACTAGACATTTGTACTAAGGTATTTCAGTTATGTAAACTCAGCCTGGGCACTTTCTGAT
AACTGTAAAATGTTTTATAAGATCATGATTATTGAAGATACATTTTGGAAAATTTTAAATGTTCGTGAGCAGCTTAACTACTTTTGTATC
TAGCCTTTTTTAAGTATCTTGTTACATTTACTTTTTTAAATAAAGAAATTACAGAAGAAATGTCAAGTAATATTGAAGAAACAATAGTTT
TTATTTATGTAGTTGTACATTTTTAAACTAAGGGCAATACACTGACATGGTTATGTGCATAAAAATTTTGACTTAAAGAACTGGAAGTTT
ATATACACCTGGACTATAAGAAACAGAAGAAAATCAGTCCACATTTTACAGTTAGCAGAGAATCCTAAATGGCACTGGCCTGGCCACCTT
TTCATTTTACAAATGGGGGAAGTGAAGTGTGACCCCTTACTTGGCATAGGAAGTTAACTTACACCTAATAACTGACAGGTTTTTGTTTTG

>57504_57504_7_NCALD-UBR5_NCALD_chr8_102731480_ENST00000522951_UBR5_chr8_103266742_ENST00000520539_length(amino acids)=196AA_BP=124
MGKQNSKLRPEVMQDLLESTDFTEHEIQEWYKGFLRDCPSGHLSMEEFKKIYGNFFPYGDASKFAEHVFRTFDANGDGTIDFREFIIALS
VTSRGKLEQKLKWAFSMYDLDGNGYISKAEMLEIVQVYFWTSSPSLPASEEGFQPMPSITIRPPDDQHLPTANTCISRLYVPLYSSKQIL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NCALD-UBR5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCALD-UBR5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCALD-UBR5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource