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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NCAM2-RORB (FusionGDB2 ID:57528) |
Fusion Gene Summary for NCAM2-RORB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NCAM2-RORB | Fusion gene ID: 57528 | Hgene | Tgene | Gene symbol | NCAM2 | RORB | Gene ID | 4685 | 6096 |
| Gene name | neural cell adhesion molecule 2 | RAR related orphan receptor B | |
| Synonyms | NCAM21 | EIG15|NR1F2|ROR-BETA|RZR-BETA|RZRB|bA133M9.1 | |
| Cytomap | 21q21.1 | 9q21.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | neural cell adhesion molecule 2N-CAM-2NCAM-2 | nuclear receptor ROR-betaRAR-related orphan receptor betanuclear receptor RZR-betanuclear receptor subfamily 1 group F member 2retinoic acid-binding receptor betaretinoid-related orphan receptor beta | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | O15394 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000284894, ENST00000400546, ENST00000486367, ENST00000535285, | ENST00000376896, ENST00000396204, | |
| Fusion gene scores | * DoF score | 15 X 9 X 7=945 | 3 X 1 X 3=9 |
| # samples | 14 | 3 | |
| ** MAII score | log2(14/945*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: NCAM2 [Title/Abstract] AND RORB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NCAM2(22370936)-RORB(77245198), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across NCAM2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across RORB (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-QC-AA9N-01A | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
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Fusion Gene ORF analysis for NCAM2-RORB |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000284894 | ENST00000376896 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
| In-frame | ENST00000284894 | ENST00000396204 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
| In-frame | ENST00000400546 | ENST00000376896 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
| In-frame | ENST00000400546 | ENST00000396204 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
| intron-3CDS | ENST00000486367 | ENST00000376896 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
| intron-3CDS | ENST00000486367 | ENST00000396204 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
| intron-3CDS | ENST00000535285 | ENST00000376896 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
| intron-3CDS | ENST00000535285 | ENST00000396204 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000400546 | NCAM2 | chr21 | 22370936 | - | ENST00000376896 | RORB | chr9 | 77245198 | + | 9236 | 304 | 243 | 1676 | 477 |
| ENST00000400546 | NCAM2 | chr21 | 22370936 | - | ENST00000396204 | RORB | chr9 | 77245198 | + | 3260 | 304 | 243 | 1676 | 477 |
| ENST00000284894 | NCAM2 | chr21 | 22370936 | - | ENST00000376896 | RORB | chr9 | 77245198 | + | 8987 | 55 | 0 | 1427 | 475 |
| ENST00000284894 | NCAM2 | chr21 | 22370936 | - | ENST00000396204 | RORB | chr9 | 77245198 | + | 3011 | 55 | 0 | 1427 | 475 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000400546 | ENST00000376896 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + | 0.000132533 | 0.99986744 |
| ENST00000400546 | ENST00000396204 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + | 0.000279587 | 0.9997204 |
| ENST00000284894 | ENST00000376896 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + | 0.000118582 | 0.9998814 |
| ENST00000284894 | ENST00000396204 | NCAM2 | chr21 | 22370936 | - | RORB | chr9 | 77245198 | + | 0.000216666 | 0.99978334 |
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Fusion Genomic Features for NCAM2-RORB |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NCAM2-RORB |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:22370936/chr9:77245198) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NCAM2 | . |
| FUNCTION: May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000376896 | 0 | 10 | 18_93 | 2 | 460.0 | DNA binding | Nuclear receptor | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000396204 | 0 | 10 | 18_93 | 13 | 471.0 | DNA binding | Nuclear receptor | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000376896 | 0 | 10 | 222_460 | 2 | 460.0 | Domain | NR LBD | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000396204 | 0 | 10 | 222_460 | 13 | 471.0 | Domain | NR LBD | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000376896 | 0 | 10 | 456_461 | 2 | 460.0 | Motif | Note=AF-2 | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000396204 | 0 | 10 | 456_461 | 13 | 471.0 | Motif | Note=AF-2 | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000376896 | 0 | 10 | 21_41 | 2 | 460.0 | Zinc finger | NR C4-type | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000376896 | 0 | 10 | 57_81 | 2 | 460.0 | Zinc finger | NR C4-type | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000396204 | 0 | 10 | 21_41 | 13 | 471.0 | Zinc finger | NR C4-type | |
| Tgene | RORB | chr21:22370936 | chr9:77245198 | ENST00000396204 | 0 | 10 | 57_81 | 13 | 471.0 | Zinc finger | NR C4-type |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 113_202 | 18 | 838.0 | Domain | Note=Ig-like C2-type 2 |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 208_297 | 18 | 838.0 | Domain | Note=Ig-like C2-type 3 |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 21_108 | 18 | 838.0 | Domain | Note=Ig-like C2-type 1 |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 302_396 | 18 | 838.0 | Domain | Note=Ig-like C2-type 4 |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 401_491 | 18 | 838.0 | Domain | Note=Ig-like C2-type 5 |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 498_591 | 18 | 838.0 | Domain | Fibronectin type-III 1 |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 593_688 | 18 | 838.0 | Domain | Fibronectin type-III 2 |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 20_697 | 18 | 838.0 | Topological domain | Extracellular |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 719_837 | 18 | 838.0 | Topological domain | Cytoplasmic |
| Hgene | NCAM2 | chr21:22370936 | chr9:77245198 | ENST00000400546 | - | 1 | 18 | 698_718 | 18 | 838.0 | Transmembrane | Helical |
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Fusion Gene Sequence for NCAM2-RORB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >57528_57528_1_NCAM2-RORB_NCAM2_chr21_22370936_ENST00000284894_RORB_chr9_77245198_ENST00000376896_length(transcript)=8987nt_BP=55nt ATGAGCCTCCTCCTCTCCTTCTACCTGCTGGGGTTGCTTGTCAGTAGCGGGCAAGCACAAATTGAAGTGATACCATGCAAAATTTGTGGC GATAAGTCCTCTGGGATCCACTACGGAGTCATCACATGTGAAGGCTGCAAGGGATTCTTTAGGAGGAGCCAGCAGAACAATGCTTCTTAT TCCTGCCCAAGGCAGAGAAACTGTTTAATTGACAGAACGAACAGAAACCGTTGCCAACACTGCCGACTGCAGAAGTGTCTTGCCCTAGGA ATGTCAAGAGATGCTGTGAAGTTTGGGAGGATGTCCAAGAAGCAAAGGGACAGCCTGTATGCTGAGGTGCAGAAGCACCAGCAGCGGCTG CAGGAACAGCGGCAGCAGCAGAGTGGGGAGGCAGAAGCCCTTGCCAGGGTGTACAGCAGCAGCATTAGCAACGGCCTGAGCAACCTGAAC AACGAGACCAGCGGCACTTATGCCAACGGGCACGTCATTGACCTGCCCAAGTCTGAGGGTTATTACAACGTCGATTCCGGTCAGCCGTCC CCTGATCAGTCAGGACTTGACATGACTGGAATCAAACAGATAAAGCAAGAACCTATCTATGACCTCACATCCGTACCCAACTTGTTTACC TATAGCTCTTTCAACAATGGGCAGTTAGCACCAGGGATAACCATGACTGAAATCGACCGAATTGCACAGAACATCATTAAGTCCCATTTG GAGACATGTCAATACACCATGGAAGAGCTGCACCAGCTGGCGTGGCAGACCCACACCTATGAAGAAATTAAAGCATATCAAAGCAAGTCC AGGGAAGCACTGTGGCAACAATGTGCCATCCAGATCACTCACGCCATCCAATACGTGGTGGAGTTTGCAAAGCGGATAACAGGCTTCATG GAGCTCTGTCAAAATGATCAAATTCTACTTCTGAAGTCAGGTTGCTTGGAAGTGGTTTTAGTGAGAATGTGCCGTGCCTTCAACCCATTA AACAACACTGTTCTGTTTGAAGGAAAATATGGAGGAATGCAAATGTTCAAAGCCTTAGGTTCTGATGACCTAGTGAATGAAGCATTTGAC TTTGCAAAGAATTTGTGTTCCTTGCAGCTGACCGAGGAGGAGATCGCTTTGTTCTCATCTGCTGTTCTGATATCTCCAGACCGAGCCTGG CTTATAGAACCAAGGAAAGTCCAGAAGCTTCAGGAAAAAATTTATTTTGCACTTCAACATGTGATTCAGAAGAATCACCTGGATGATGAG ACCTTGGCAAAGTTAATAGCCAAGATACCAACCATCACGGCAGTTTGCAACTTGCACGGGGAGAAGCTGCAGGTATTTAAGCAATCTCAT CCAGAGATAGTGAATACACTGTTTCCTCCGTTATACAAGGAGCTCTTTAATCCTGACTGTGCCACCGGCTGCAAATGAAGGGGACAAGAG AACTGTCTCATAGTCATGGAATGCATCACCATTAAGACAAAAGCAATGTGTTCATGAAGACTTAAGAAAAATGTCACTACTGCAACATTA GGAATGTCCTGCACTTAATAGAATTATTTTTCACCGCTACAGTTTGAAGAATGTAAATATGCACCTGAGTGGGGCTCTTTTATTTGTTTG TTTGTTTTTGAAATGACCATAAATATACAAATATAGGACACTGGGTGTTATCCTTTTTTTAATTTTATTCGGGTATGTTTTGGGAGACAA CTGTTTATAGAATTTTATTGTAGATATATACAAGAAAAGAGCGGTACTTTACATGATTACTTTTCCTGTTGATTGTTCAAATATAATTTA AGAAAATTCCACTTAATAGGCTTACCTATTTCTATGTTTTTAGGTAGTTGATGCATGTGTAAATTTGTAGCTGTCTTGGAAAGTACTGTG CATGTATGTAATAAGTATATAATATGTGAGAATATTATATATGACTATTACTTATACATGCACATGCACTGTGGCTTAAATACCATACCT ACTAGCAATGGAGGTTCAGTCAGGCTCTCTTCTATGATTTACCTTCTGTGTTATATGTTACCTTTATGTTAGACAATCAGGATTTTGTTT TCCCAGCCAGAGTTTTCATCTATAGTCAATGGCAGGACGGTACCAACTCAGAGTTAAGTCTACAAAGGAATAAACATAATGTGTGGCCTC TATATACAAACTCTATTTCTGTCAATGACATCAAAGCCTTGTCAAGATGGTTCATATTGGGAAGGAGACAGTATTTTAAGCCATTTTCCT GTTTCAAGAATTAGGCCACAGATAACATTGCAAGGTCCAAGACTTTTTTGACCAAACAGTAGATATTTTCTATTTTTCACCAGAACACAT AAAAACACTTTTTTTCTTTTGGATTTCTGGTTGTGAAACAAGCTTGATTTCAGTGCTTATTGTGTCTTCAACTGAAAAATACAATCTGTG GATTATGACTACCAGCAATTTTTTTCTAGGAAAGTTAAAAGAATAAATCAGAACCCAGGGCAACAATGCCATTTCATGTAAACATTTTCT CTCTCACCATGTTTTGGCAAGAAAAGGTAGAAAGAGAAGACCCAGAGTGAAGAAGTAATTCTTTATATTCCTTTCTTTAATGTATTTGTT AGGAAAAGTGGCAATAAAGGGGGAGGCATATTATAAAATGCTATAATATAAAAATGTAGCAAAAACTTGACAGACTAGAAAAAAAAAGAT CTGTGTTATTCTAGGGAACTAATGTACCCCAAAGCCAAAACTAATTCCTGTGAAGTTTACAGTTACATCATCCATTTACCCTAGAATTAT TTTTTTAGCAACTTTTAGAAATAAAGAATACAACTGTGACATTAGGATCAGAGATTTTAGACTTCCTTGTACAAATTCTCACTTCTCCAC CTGCTCACCAATGAAATTAATCATAAGAAAAGCATATATTCCAAGAAATTTGTTCTGCCTGTGTCCTGGAGGCCTATACCTCTGTTATTT TCTGATACAAAATAAAACTTAAAAAAAAGAAAACAAGCTAAGAGAGAAGTTTGTGTATAAGACAATGAAAATTATGGTCTCCTGTAAGTA TATCCCAGCCACCAACTCCTAAAGAACTGCCCTTTTCTCCATATTAAACACACACACACTTACACACACACACATACAAACCCCTGCTTT GTAAAGTTTCCATCAGTGGAAACTTTGATTTCTTTTTTTAATCTCTTATGCTCTCCTGAAGTTCATGGTTGAGCACCATCTCCAAGATAC CACAGAACTCTTGATTGATGATCAAAACAGTAGTGTCATCTTTTCCTTTTAGAAAACGGAACATTTTCTCACCTCATGATTGATGAATTC TAAACCAATGGGGAAAAACAAAAAGGCTTTAAAATAATGAATCTGTTTCTCAACTACTGTTATATTCAATTAATTTAACTACATTGAACC AAATTACCTTTGGTTCTAAGAAGACAGCTGTAGACTGCTTATTATGCTGCTACAGGGACTCAATTCTTTTTGGTGTAAATGTCACTCCTG CTAGCTCTTTGTATAAAGAATTAATTCCCAGAGTCATATTTCCTTCTAATGGAAAGATTACTCTACTGATTGCTAGGAAAACAGGGTAAT GGAAGGCACTCAATTAAACCAAGCCGTTTCCAAATGCAATGTATGTTTTATGATTGGCTTGTGATAGGCGATGCTTCATGTGTCTACTTG GTGTTTCCCTTTGAGCTTTGAACTTATGTCAAACTTTGTTTTCATTGTTCTGTTGGCCTAGTGTTTTCCATTGTCAGCCTGTAATTCCTG CTCAGTTGCAGAGGGAATTATTTATTTCCTCCAATTTACCTTAGAGGATTTAAATTGGCTCAATTGATGAAGTGGCTCAGAATTTTTTCC TCCCTTTTCCCATGGGTGATATAGGAAAAAGATTGTTCCCCACATTTACCTTGGGAGGTACTGCTTTGAATTTGTGTTGTTTCCACTAGC GTTAAGCATTTCACTGGGACGGCATGGACCTTTTGAAGCTGGGAGGAAGGAAACAGAGCTAGCATCTGAACCAGAGCAAAACAATGGCAA CCAGGACATACTCATCCCACTTAGTTGAGAGAAGAGATTTCTAGTTTGGGTTACAGTTGCCCAACCTTCCCTTTAAAGAGAATCCAGTCA TGTTTTCAATGGTAAAAAGCCTTAAAAAGCTGCCCTTCGAAGATCTCCTATGACTGCATGTCAAGGTATTTTGTACCTACAATCCCAGAA CTTGGTTCCTTCCCCATGAGGACTAACAAATGTTCACAACAATCATGATCAAGTGTGCACTGGAAGAAAAAATCCACAATCTGGGCTTCT CACTTCGTGCTTCATAAATGACAATCACTGCTTGATGCAGATGTTGCACTGTATCCACTCAGGGATGTTTCCTTAAAAAAAAAAAATACA TCAAGAAGGAGGAAAAAATTAAAAACAGGAAAATGACAACAAAATGTGAATGGTATAAATTAAATATGTTGCTGAGAGCACCTCTCTGAC AAGGCTTTCAGACCAACAAGCAGTAACTTCATGTCATAAACTAGATTGACTTATTTGGACTTGCTGAAAAGTTGCACCCAAGTAAGGACA ACTTGGTCTCATTTTCTAAACTCTGCTAAGAGCCAAATAATCTAGCTGTCCCATTCAGAGGAATTTTTATCTCCCTGCAAATCCAAACTT TCTATACAAATCCTGAACAAGGAAAATACAGAAATCTAACTGGCATTAGATAAAATGGACAAGGGAGGTGAAACCGGGTGAATTCAAACT TCAGTGTATTTGTGGTCCATAAAAAGAAAGGGAAATTTTGGAGGGAAAATAGGACAGGAAAGGATTCCAAATCTGGTTTGACACCCGTAT ATGCCCGTACTGTCCATGACTCAACTAATCTCTTTGCCCCTTTTTCTGTGGCTCCTTTTTTGTTTTGAGACAGATCTTGTTCAACATGTT GCTCAGGCTGGAGTGCAGTGGCATGAGATCTTGGCTCGCTGCAATCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCTTCAGCCTCCTGA GTAGCTGGGATTACAGGCACACGCCCCCACACCCGGCTAATTTTTGTATTTTAGGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGT CCTGAACTCCTGACCTCAAGTGATCCACCCGCCTTGGCCTCCCAAAGTGCAAGGATTACAGGCCTGAGCCACTGCGCCCTGCCTTCAGTG GCTCTTTTATCCCCCAAAGACTGAAAGCTGAAGGTGGAGATGTTCTCCACAAACATACCCTTTCTGAATTTCCCTTGTTTTAGCACTGTG TTCAGGGCTCTGGACTAAAGTACCTCTGAGTAGGTAAAATCAGAGAATATAACGATCTCCTGAGTGATTAGATTTCTTTGGTAGATTCCA AGAGATCTTAAATCATAATAAACTCTGAATATTAACAAGAGGTGCCAGGGAGGTGTCAGTACATTTCCTATCATAGCTGCCTTGTTCAAA GCATAATCTCAGAGCAGTCAAGCTAAACTGTTTGTAGAAAACCATGAAGATCAACTCATGCTCACTCTCTACAATGCAATGTGTACGAGG CTTGAAGGCAAAAACAATTCTTGGGTCCCAAGGACAACCTAAAACTTACCAGCTTTTTTCAAAAACAACAATCAGATGCAAATAATGGCA GTGTTGTTCTATGTTCTTTGTTTCTGTTCATTATAGAAGCAAGGAAAAATTCTATTTCTATTGGAAATTAGAAGAAATAATTTCTTCCTG ACTCTTTTTTTTTCTATAAACTTTTATTTCCAAGGAAGCTGCTACAATTTGCAGTCAATTCAGGCCATGGACGTCTGTGCCCTAACAGAA GCACCGTTCAATAGAACAGCAATAACCTTAAAGTGTGCATCTGTAGTGAAACTCTGCACAAAGTCCCCTGCATAAAGAAGAGAGGAAAGC CTACCATCTGCTTTAGACGAAGTGTTATTTGATGTTCTGTTTCCAACTGTCAGTATAAGCAGCAACTAGAGTAAAGGCCTGATGTGGGAA ACTATGGGGGGTCTTTCAAAAAAAAGCTGACACTCTATTCATTTTTGGGTCTCAGGACCAGAGGGTACAGGGTAGAGGGTAGTTTACCAT TTAAAGCAGGGGTTGAAAATTCGAAAGCCTAAAAGGGCCAGGGGGCTTAATGCAAATGGGTGAAGCAGCCCAGGGGCAAGCTGGCCAGGA AATGCCCTGTGGAAAAAGGGACATCCACGATTTACCTGAAACTGAATGCTGCTAGAGCTTCTGAATTTTATAAAATCTCTGAAATTATAC ATGATGGCAGTTGATTCAGAGCTTAGTGCAGACCAAACAAATACATCACTGAGCAGAAGAGGGCCCATAGATCGTCAGCTTGCAGCCTCT GGTTTAAAGCAAAATCGCATCTGGGGCCAGCTCAACTGCAGCAAGTCTGGTCAGATTCAACCCTGGACGATATTAGAATGATATTAGTTT TGGAAGGAGGGGATGGAGATCTTCCCCTTCTAATACTCAATTTTGTTTTGGTATTTGATTGTCACAACTAGAGGATATAACAGGAGGTCA GTTTAAAAAATAGCAAACAGTCTAAAAATGAAAACTATTCAATTTAGTGATGGCTTATAAAAGACACTCCAACTTGTCTTGCCCAAACTC CCTTCTTCATAGAGCCAGGGGGCTGGATTTCTTGCCACTTTTTTTCTGAAAGGCAAATGCATGACTTTTATTCTTTTGGGTCTCAGTGTG TTTCTTGAACTGTGTGACTTCAATATCTGTGACAAGTTTTTATTTTCCCTTAGTTGTATGTGAAGAATTTATTCTATAGTCGTGATCATG TAGTCCTCCATTGTTTGGAAGTGCAGACCATGGATTCCTATGCAGCAGATGGGGGTTGTCTGTTTGTGCACTTTTTTCCTAAGCTGCTGA AATTCCTCCGATGTGAATGGGCCATAGTAATCTTTGCCTCCTGCGTGACTGTAAGCATGGCCTCCAGTGGATCAGAGAAAGCAGCTCAGT GATTGTTCTCATGGCCAAAAATAAAGCACAAGGGTTACCGGAATTGAATGAGCCCTGTTCAGGGCAGCACGGGGCATCTGCACCCCAGCT GGGCAGCATGATCCTTGTATTCAACTATACTCTTCTGGCAGTAGTTGGTGGCAAGCATTCGCGTGCCTCTGTCACAACCATACGTAGAAA CACATTAGGTATGTCTGGAAAGCTACAAATCCCACATCCAAGCACAGTACCGTCTGCTTCATCTGATTAACACACACACAAGAAAGAAAA ATTACACCCACAGAAAACTGAGTATGTATTGTAGAAATGTAGAGGAAAAATAAAAATATTTTTTCAAATGTAATTACTTTTAATATATGC TTGTGGAAGGTCTAATACAATGTATGCTGTCTCTGTAATTTTTGCTGTAAATAACTGGAGACGGTGAGTACACTGATTTTTCTATGTCTC TGTTTAAGCATAAGACTTTGTAACAATTTTTTTAGAGGGGGAAAATCAACAAAGAGCAAATATGTACTTGCTTCCTTTCTGCGTGTTATG TACTTCTCAGTTTTTTAATGGAAACTGGTTGTAACAGTTTAAGCATCTTGACGGGTCATTGGTGTTAAGTGTATGCTTCTTTTTGTAATA TGACTGAGAAAGGGACAGGGCTGTCAATTAAATCTGCTCCAAAGAATTTGTATTGAAGATTGGCCTAAGACCTGCAAACTCCATCTATAA CTAGAAAATACGAAAAAGGAAAATTAAAAAAAAAAGTTGCCTGAGTTAAGTCATCTTTCCTTGTAGCAAATGGCTTTGTCCAAATCCTTT CTGCATGGAATAGCTTAAGGAAAACAAACTCCGCTTTCTGATGAACAAGATATTTTTGTACACATTTATTTCTTGTTAATAACCTGAGGT CAGACCACTCATTTGCTGAAGCCATAACTGACCTTCACCAAATAAATGTTGTAAAGAACCTAGGGGAGGGTTGGGGAGAGACTGAGAGGG AGGAAAATCCAAGGTGTCATGAGCTATAGCAACACAGGCAGGAGCAAGTTGTTGAAACTGATGCTTTTCCTGCATCCCAAATATGACTTT AAAAGGCTAGTATTTTATGATGATCGATTTATAATGATAAAAAGATATTTAGATTTAAATGAGACATTCCAATATTTTTGAAATCCCTAA CAATGCTTCCTTGCTTTTAGGATTGAGAGAAATGATTTTCATATACTTCCAACATTCAGAGATTTAATGTTTTTACCTTAGCTCCAGCCT ACGCTTGTAAAGTGAAGAGTGATTCTAAGTCCCGTGAAACCGTGGGCTGCCTGGGGCTTGGCTGTGCCCACTAACCTACTGCGCCTGGGG GGCAGCATGGGAGGGGTACAGTTTGCATCTCATTAGCATGCACACCACTGTTGGCAATGCATAAAAGTTGCATTGCCACAAGTATGTAAA ATAAAAATATTCACTCTAAAAAGAATAATAATTCTACTTTTTTAAAAGAATAATGTCTCTTATAGTCACCATTGATTTTTCTGGAGTTTA ATTACATTATTACCATGTATTCTTATTGGCCTGTAGAGGAAAAAGGCAAACCACAAATAAACCCAGTGACATATATAGTTTTAAAATCTA CAATTTTCTGATCTCTCTCTCCTTGTTTAATATATAAGCCCTAATTTCTGTGTATGTGAGTAAAACTGCAGCCTGAGTCATTTAGGAAGT AAGTATTGAGTTTTTTTAATCATAAATATACTAGAATAAAACAGCACTCCCTAACAATTAAAAAAGAGTTTTATATTACTTTAGAATGTA ATAGGTTTTTGTCCTTATTTTATGTCCTGTAAATTATTAGTTCAATACTGTTAGCATTCCCGGATAATGCACACATGATTTCTGAATGTT >57528_57528_1_NCAM2-RORB_NCAM2_chr21_22370936_ENST00000284894_RORB_chr9_77245198_ENST00000376896_length(amino acids)=475AA_BP=18 MSLLLSFYLLGLLVSSGQAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALG MSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPS PDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKS REALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFD FAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSH -------------------------------------------------------------- >57528_57528_2_NCAM2-RORB_NCAM2_chr21_22370936_ENST00000284894_RORB_chr9_77245198_ENST00000396204_length(transcript)=3011nt_BP=55nt ATGAGCCTCCTCCTCTCCTTCTACCTGCTGGGGTTGCTTGTCAGTAGCGGGCAAGCACAAATTGAAGTGATACCATGCAAAATTTGTGGC GATAAGTCCTCTGGGATCCACTACGGAGTCATCACATGTGAAGGCTGCAAGGGATTCTTTAGGAGGAGCCAGCAGAACAATGCTTCTTAT TCCTGCCCAAGGCAGAGAAACTGTTTAATTGACAGAACGAACAGAAACCGTTGCCAACACTGCCGACTGCAGAAGTGTCTTGCCCTAGGA ATGTCAAGAGATGCTGTGAAGTTTGGGAGGATGTCCAAGAAGCAAAGGGACAGCCTGTATGCTGAGGTGCAGAAGCACCAGCAGCGGCTG CAGGAACAGCGGCAGCAGCAGAGTGGGGAGGCAGAAGCCCTTGCCAGGGTGTACAGCAGCAGCATTAGCAACGGCCTGAGCAACCTGAAC AACGAGACCAGCGGCACTTATGCCAACGGGCACGTCATTGACCTGCCCAAGTCTGAGGGTTATTACAACGTCGATTCCGGTCAGCCGTCC CCTGATCAGTCAGGACTTGACATGACTGGAATCAAACAGATAAAGCAAGAACCTATCTATGACCTCACATCCGTACCCAACTTGTTTACC TATAGCTCTTTCAACAATGGGCAGTTAGCACCAGGGATAACCATGACTGAAATCGACCGAATTGCACAGAACATCATTAAGTCCCATTTG GAGACATGTCAATACACCATGGAAGAGCTGCACCAGCTGGCGTGGCAGACCCACACCTATGAAGAAATTAAAGCATATCAAAGCAAGTCC AGGGAAGCACTGTGGCAACAATGTGCCATCCAGATCACTCACGCCATCCAATACGTGGTGGAGTTTGCAAAGCGGATAACAGGCTTCATG GAGCTCTGTCAAAATGATCAAATTCTACTTCTGAAGTCAGGTTGCTTGGAAGTGGTTTTAGTGAGAATGTGCCGTGCCTTCAACCCATTA AACAACACTGTTCTGTTTGAAGGAAAATATGGAGGAATGCAAATGTTCAAAGCCTTAGGTTCTGATGACCTAGTGAATGAAGCATTTGAC TTTGCAAAGAATTTGTGTTCCTTGCAGCTGACCGAGGAGGAGATCGCTTTGTTCTCATCTGCTGTTCTGATATCTCCAGACCGAGCCTGG CTTATAGAACCAAGGAAAGTCCAGAAGCTTCAGGAAAAAATTTATTTTGCACTTCAACATGTGATTCAGAAGAATCACCTGGATGATGAG ACCTTGGCAAAGTTAATAGCCAAGATACCAACCATCACGGCAGTTTGCAACTTGCACGGGGAGAAGCTGCAGGTATTTAAGCAATCTCAT CCAGAGATAGTGAATACACTGTTTCCTCCGTTATACAAGGAGCTCTTTAATCCTGACTGTGCCACCGGCTGCAAATGAAGGGGACAAGAG AACTGTCTCATAGTCATGGAATGCATCACCATTAAGACAAAAGCAATGTGTTCATGAAGACTTAAGAAAAATGTCACTACTGCAACATTA GGAATGTCCTGCACTTAATAGAATTATTTTTCACCGCTACAGTTTGAAGAATGTAAATATGCACCTGAGTGGGGCTCTTTTATTTGTTTG TTTGTTTTTGAAATGACCATAAATATACAAATATAGGACACTGGGTGTTATCCTTTTTTTAATTTTATTCGGGTATGTTTTGGGAGACAA CTGTTTATAGAATTTTATTGTAGATATATACAAGAAAAGAGCGGTACTTTACATGATTACTTTTCCTGTTGATTGTTCAAATATAATTTA AGAAAATTCCACTTAATAGGCTTACCTATTTCTATGTTTTTAGGTAGTTGATGCATGTGTAAATTTGTAGCTGTCTTGGAAAGTACTGTG CATGTATGTAATAAGTATATAATATGTGAGAATATTATATATGACTATTACTTATACATGCACATGCACTGTGGCTTAAATACCATACCT ACTAGCAATGGAGGTTCAGTCAGGCTCTCTTCTATGATTTACCTTCTGTGTTATATGTTACCTTTATGTTAGACAATCAGGATTTTGTTT TCCCAGCCAGAGTTTTCATCTATAGTCAATGGCAGGACGGTACCAACTCAGAGTTAAGTCTACAAAGGAATAAACATAATGTGTGGCCTC TATATACAAACTCTATTTCTGTCAATGACATCAAAGCCTTGTCAAGATGGTTCATATTGGGAAGGAGACAGTATTTTAAGCCATTTTCCT GTTTCAAGAATTAGGCCACAGATAACATTGCAAGGTCCAAGACTTTTTTGACCAAACAGTAGATATTTTCTATTTTTCACCAGAACACAT AAAAACACTTTTTTTCTTTTGGATTTCTGGTTGTGAAACAAGCTTGATTTCAGTGCTTATTGTGTCTTCAACTGAAAAATACAATCTGTG GATTATGACTACCAGCAATTTTTTTCTAGGAAAGTTAAAAGAATAAATCAGAACCCAGGGCAACAATGCCATTTCATGTAAACATTTTCT CTCTCACCATGTTTTGGCAAGAAAAGGTAGAAAGAGAAGACCCAGAGTGAAGAAGTAATTCTTTATATTCCTTTCTTTAATGTATTTGTT AGGAAAAGTGGCAATAAAGGGGGAGGCATATTATAAAATGCTATAATATAAAAATGTAGCAAAAACTTGACAGACTAGAAAAAAAAAGAT CTGTGTTATTCTAGGGAACTAATGTACCCCAAAGCCAAAACTAATTCCTGTGAAGTTTACAGTTACATCATCCATTTACCCTAGAATTAT TTTTTTAGCAACTTTTAGAAATAAAGAATACAACTGTGACATTAGGATCAGAGATTTTAGACTTCCTTGTACAAATTCTCACTTCTCCAC CTGCTCACCAATGAAATTAATCATAAGAAAAGCATATATTCCAAGAAATTTGTTCTGCCTGTGTCCTGGAGGCCTATACCTCTGTTATTT >57528_57528_2_NCAM2-RORB_NCAM2_chr21_22370936_ENST00000284894_RORB_chr9_77245198_ENST00000396204_length(amino acids)=475AA_BP=18 MSLLLSFYLLGLLVSSGQAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALG MSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQPS PDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQSKS REALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEAFD FAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQSH -------------------------------------------------------------- >57528_57528_3_NCAM2-RORB_NCAM2_chr21_22370936_ENST00000400546_RORB_chr9_77245198_ENST00000376896_length(transcript)=9236nt_BP=304nt GCTGCCGCCGCGGCGGCCGCTGCTGCTGCTGCTTCTGCCGCCGCTGCCGCCGCCGCTGCCTGGATATAGTGCGGCAAGAGCGGAGCTTGC AGTCACTTTGCGAGGAGGAGCGCGCGGGCTGCGGGCGGCTGGGGCACCGCGGGAGCGGCGGCGGCGGCTCTAGCAGAGGCGGCCGGGGCA GCGAAAGGTTCTCTCTCCAGGGCTGGACTTAATAACTTTGAAACTGTCCACCGGTGTCACGTCCTGAACATGAGCCTCCTCCTCTCCTTC TACCTGCTGGGGTTGCTTGTCAGTAGCGGGCAAGCACAAATTGAAGTGATACCATGCAAAATTTGTGGCGATAAGTCCTCTGGGATCCAC TACGGAGTCATCACATGTGAAGGCTGCAAGGGATTCTTTAGGAGGAGCCAGCAGAACAATGCTTCTTATTCCTGCCCAAGGCAGAGAAAC TGTTTAATTGACAGAACGAACAGAAACCGTTGCCAACACTGCCGACTGCAGAAGTGTCTTGCCCTAGGAATGTCAAGAGATGCTGTGAAG TTTGGGAGGATGTCCAAGAAGCAAAGGGACAGCCTGTATGCTGAGGTGCAGAAGCACCAGCAGCGGCTGCAGGAACAGCGGCAGCAGCAG AGTGGGGAGGCAGAAGCCCTTGCCAGGGTGTACAGCAGCAGCATTAGCAACGGCCTGAGCAACCTGAACAACGAGACCAGCGGCACTTAT GCCAACGGGCACGTCATTGACCTGCCCAAGTCTGAGGGTTATTACAACGTCGATTCCGGTCAGCCGTCCCCTGATCAGTCAGGACTTGAC ATGACTGGAATCAAACAGATAAAGCAAGAACCTATCTATGACCTCACATCCGTACCCAACTTGTTTACCTATAGCTCTTTCAACAATGGG CAGTTAGCACCAGGGATAACCATGACTGAAATCGACCGAATTGCACAGAACATCATTAAGTCCCATTTGGAGACATGTCAATACACCATG GAAGAGCTGCACCAGCTGGCGTGGCAGACCCACACCTATGAAGAAATTAAAGCATATCAAAGCAAGTCCAGGGAAGCACTGTGGCAACAA TGTGCCATCCAGATCACTCACGCCATCCAATACGTGGTGGAGTTTGCAAAGCGGATAACAGGCTTCATGGAGCTCTGTCAAAATGATCAA ATTCTACTTCTGAAGTCAGGTTGCTTGGAAGTGGTTTTAGTGAGAATGTGCCGTGCCTTCAACCCATTAAACAACACTGTTCTGTTTGAA GGAAAATATGGAGGAATGCAAATGTTCAAAGCCTTAGGTTCTGATGACCTAGTGAATGAAGCATTTGACTTTGCAAAGAATTTGTGTTCC TTGCAGCTGACCGAGGAGGAGATCGCTTTGTTCTCATCTGCTGTTCTGATATCTCCAGACCGAGCCTGGCTTATAGAACCAAGGAAAGTC CAGAAGCTTCAGGAAAAAATTTATTTTGCACTTCAACATGTGATTCAGAAGAATCACCTGGATGATGAGACCTTGGCAAAGTTAATAGCC AAGATACCAACCATCACGGCAGTTTGCAACTTGCACGGGGAGAAGCTGCAGGTATTTAAGCAATCTCATCCAGAGATAGTGAATACACTG TTTCCTCCGTTATACAAGGAGCTCTTTAATCCTGACTGTGCCACCGGCTGCAAATGAAGGGGACAAGAGAACTGTCTCATAGTCATGGAA TGCATCACCATTAAGACAAAAGCAATGTGTTCATGAAGACTTAAGAAAAATGTCACTACTGCAACATTAGGAATGTCCTGCACTTAATAG AATTATTTTTCACCGCTACAGTTTGAAGAATGTAAATATGCACCTGAGTGGGGCTCTTTTATTTGTTTGTTTGTTTTTGAAATGACCATA AATATACAAATATAGGACACTGGGTGTTATCCTTTTTTTAATTTTATTCGGGTATGTTTTGGGAGACAACTGTTTATAGAATTTTATTGT AGATATATACAAGAAAAGAGCGGTACTTTACATGATTACTTTTCCTGTTGATTGTTCAAATATAATTTAAGAAAATTCCACTTAATAGGC TTACCTATTTCTATGTTTTTAGGTAGTTGATGCATGTGTAAATTTGTAGCTGTCTTGGAAAGTACTGTGCATGTATGTAATAAGTATATA ATATGTGAGAATATTATATATGACTATTACTTATACATGCACATGCACTGTGGCTTAAATACCATACCTACTAGCAATGGAGGTTCAGTC AGGCTCTCTTCTATGATTTACCTTCTGTGTTATATGTTACCTTTATGTTAGACAATCAGGATTTTGTTTTCCCAGCCAGAGTTTTCATCT ATAGTCAATGGCAGGACGGTACCAACTCAGAGTTAAGTCTACAAAGGAATAAACATAATGTGTGGCCTCTATATACAAACTCTATTTCTG TCAATGACATCAAAGCCTTGTCAAGATGGTTCATATTGGGAAGGAGACAGTATTTTAAGCCATTTTCCTGTTTCAAGAATTAGGCCACAG ATAACATTGCAAGGTCCAAGACTTTTTTGACCAAACAGTAGATATTTTCTATTTTTCACCAGAACACATAAAAACACTTTTTTTCTTTTG GATTTCTGGTTGTGAAACAAGCTTGATTTCAGTGCTTATTGTGTCTTCAACTGAAAAATACAATCTGTGGATTATGACTACCAGCAATTT TTTTCTAGGAAAGTTAAAAGAATAAATCAGAACCCAGGGCAACAATGCCATTTCATGTAAACATTTTCTCTCTCACCATGTTTTGGCAAG AAAAGGTAGAAAGAGAAGACCCAGAGTGAAGAAGTAATTCTTTATATTCCTTTCTTTAATGTATTTGTTAGGAAAAGTGGCAATAAAGGG GGAGGCATATTATAAAATGCTATAATATAAAAATGTAGCAAAAACTTGACAGACTAGAAAAAAAAAGATCTGTGTTATTCTAGGGAACTA ATGTACCCCAAAGCCAAAACTAATTCCTGTGAAGTTTACAGTTACATCATCCATTTACCCTAGAATTATTTTTTTAGCAACTTTTAGAAA TAAAGAATACAACTGTGACATTAGGATCAGAGATTTTAGACTTCCTTGTACAAATTCTCACTTCTCCACCTGCTCACCAATGAAATTAAT CATAAGAAAAGCATATATTCCAAGAAATTTGTTCTGCCTGTGTCCTGGAGGCCTATACCTCTGTTATTTTCTGATACAAAATAAAACTTA AAAAAAAGAAAACAAGCTAAGAGAGAAGTTTGTGTATAAGACAATGAAAATTATGGTCTCCTGTAAGTATATCCCAGCCACCAACTCCTA AAGAACTGCCCTTTTCTCCATATTAAACACACACACACTTACACACACACACATACAAACCCCTGCTTTGTAAAGTTTCCATCAGTGGAA ACTTTGATTTCTTTTTTTAATCTCTTATGCTCTCCTGAAGTTCATGGTTGAGCACCATCTCCAAGATACCACAGAACTCTTGATTGATGA TCAAAACAGTAGTGTCATCTTTTCCTTTTAGAAAACGGAACATTTTCTCACCTCATGATTGATGAATTCTAAACCAATGGGGAAAAACAA AAAGGCTTTAAAATAATGAATCTGTTTCTCAACTACTGTTATATTCAATTAATTTAACTACATTGAACCAAATTACCTTTGGTTCTAAGA AGACAGCTGTAGACTGCTTATTATGCTGCTACAGGGACTCAATTCTTTTTGGTGTAAATGTCACTCCTGCTAGCTCTTTGTATAAAGAAT TAATTCCCAGAGTCATATTTCCTTCTAATGGAAAGATTACTCTACTGATTGCTAGGAAAACAGGGTAATGGAAGGCACTCAATTAAACCA AGCCGTTTCCAAATGCAATGTATGTTTTATGATTGGCTTGTGATAGGCGATGCTTCATGTGTCTACTTGGTGTTTCCCTTTGAGCTTTGA ACTTATGTCAAACTTTGTTTTCATTGTTCTGTTGGCCTAGTGTTTTCCATTGTCAGCCTGTAATTCCTGCTCAGTTGCAGAGGGAATTAT TTATTTCCTCCAATTTACCTTAGAGGATTTAAATTGGCTCAATTGATGAAGTGGCTCAGAATTTTTTCCTCCCTTTTCCCATGGGTGATA TAGGAAAAAGATTGTTCCCCACATTTACCTTGGGAGGTACTGCTTTGAATTTGTGTTGTTTCCACTAGCGTTAAGCATTTCACTGGGACG GCATGGACCTTTTGAAGCTGGGAGGAAGGAAACAGAGCTAGCATCTGAACCAGAGCAAAACAATGGCAACCAGGACATACTCATCCCACT TAGTTGAGAGAAGAGATTTCTAGTTTGGGTTACAGTTGCCCAACCTTCCCTTTAAAGAGAATCCAGTCATGTTTTCAATGGTAAAAAGCC TTAAAAAGCTGCCCTTCGAAGATCTCCTATGACTGCATGTCAAGGTATTTTGTACCTACAATCCCAGAACTTGGTTCCTTCCCCATGAGG ACTAACAAATGTTCACAACAATCATGATCAAGTGTGCACTGGAAGAAAAAATCCACAATCTGGGCTTCTCACTTCGTGCTTCATAAATGA CAATCACTGCTTGATGCAGATGTTGCACTGTATCCACTCAGGGATGTTTCCTTAAAAAAAAAAAATACATCAAGAAGGAGGAAAAAATTA AAAACAGGAAAATGACAACAAAATGTGAATGGTATAAATTAAATATGTTGCTGAGAGCACCTCTCTGACAAGGCTTTCAGACCAACAAGC AGTAACTTCATGTCATAAACTAGATTGACTTATTTGGACTTGCTGAAAAGTTGCACCCAAGTAAGGACAACTTGGTCTCATTTTCTAAAC TCTGCTAAGAGCCAAATAATCTAGCTGTCCCATTCAGAGGAATTTTTATCTCCCTGCAAATCCAAACTTTCTATACAAATCCTGAACAAG GAAAATACAGAAATCTAACTGGCATTAGATAAAATGGACAAGGGAGGTGAAACCGGGTGAATTCAAACTTCAGTGTATTTGTGGTCCATA AAAAGAAAGGGAAATTTTGGAGGGAAAATAGGACAGGAAAGGATTCCAAATCTGGTTTGACACCCGTATATGCCCGTACTGTCCATGACT CAACTAATCTCTTTGCCCCTTTTTCTGTGGCTCCTTTTTTGTTTTGAGACAGATCTTGTTCAACATGTTGCTCAGGCTGGAGTGCAGTGG CATGAGATCTTGGCTCGCTGCAATCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCTTCAGCCTCCTGAGTAGCTGGGATTACAGGCACA CGCCCCCACACCCGGCTAATTTTTGTATTTTAGGTAGAGATGGGGTTTCACCATGTTGGCCAGGCTGGTCCTGAACTCCTGACCTCAAGT GATCCACCCGCCTTGGCCTCCCAAAGTGCAAGGATTACAGGCCTGAGCCACTGCGCCCTGCCTTCAGTGGCTCTTTTATCCCCCAAAGAC TGAAAGCTGAAGGTGGAGATGTTCTCCACAAACATACCCTTTCTGAATTTCCCTTGTTTTAGCACTGTGTTCAGGGCTCTGGACTAAAGT ACCTCTGAGTAGGTAAAATCAGAGAATATAACGATCTCCTGAGTGATTAGATTTCTTTGGTAGATTCCAAGAGATCTTAAATCATAATAA ACTCTGAATATTAACAAGAGGTGCCAGGGAGGTGTCAGTACATTTCCTATCATAGCTGCCTTGTTCAAAGCATAATCTCAGAGCAGTCAA GCTAAACTGTTTGTAGAAAACCATGAAGATCAACTCATGCTCACTCTCTACAATGCAATGTGTACGAGGCTTGAAGGCAAAAACAATTCT TGGGTCCCAAGGACAACCTAAAACTTACCAGCTTTTTTCAAAAACAACAATCAGATGCAAATAATGGCAGTGTTGTTCTATGTTCTTTGT TTCTGTTCATTATAGAAGCAAGGAAAAATTCTATTTCTATTGGAAATTAGAAGAAATAATTTCTTCCTGACTCTTTTTTTTTCTATAAAC TTTTATTTCCAAGGAAGCTGCTACAATTTGCAGTCAATTCAGGCCATGGACGTCTGTGCCCTAACAGAAGCACCGTTCAATAGAACAGCA ATAACCTTAAAGTGTGCATCTGTAGTGAAACTCTGCACAAAGTCCCCTGCATAAAGAAGAGAGGAAAGCCTACCATCTGCTTTAGACGAA GTGTTATTTGATGTTCTGTTTCCAACTGTCAGTATAAGCAGCAACTAGAGTAAAGGCCTGATGTGGGAAACTATGGGGGGTCTTTCAAAA AAAAGCTGACACTCTATTCATTTTTGGGTCTCAGGACCAGAGGGTACAGGGTAGAGGGTAGTTTACCATTTAAAGCAGGGGTTGAAAATT CGAAAGCCTAAAAGGGCCAGGGGGCTTAATGCAAATGGGTGAAGCAGCCCAGGGGCAAGCTGGCCAGGAAATGCCCTGTGGAAAAAGGGA CATCCACGATTTACCTGAAACTGAATGCTGCTAGAGCTTCTGAATTTTATAAAATCTCTGAAATTATACATGATGGCAGTTGATTCAGAG CTTAGTGCAGACCAAACAAATACATCACTGAGCAGAAGAGGGCCCATAGATCGTCAGCTTGCAGCCTCTGGTTTAAAGCAAAATCGCATC TGGGGCCAGCTCAACTGCAGCAAGTCTGGTCAGATTCAACCCTGGACGATATTAGAATGATATTAGTTTTGGAAGGAGGGGATGGAGATC TTCCCCTTCTAATACTCAATTTTGTTTTGGTATTTGATTGTCACAACTAGAGGATATAACAGGAGGTCAGTTTAAAAAATAGCAAACAGT CTAAAAATGAAAACTATTCAATTTAGTGATGGCTTATAAAAGACACTCCAACTTGTCTTGCCCAAACTCCCTTCTTCATAGAGCCAGGGG GCTGGATTTCTTGCCACTTTTTTTCTGAAAGGCAAATGCATGACTTTTATTCTTTTGGGTCTCAGTGTGTTTCTTGAACTGTGTGACTTC AATATCTGTGACAAGTTTTTATTTTCCCTTAGTTGTATGTGAAGAATTTATTCTATAGTCGTGATCATGTAGTCCTCCATTGTTTGGAAG TGCAGACCATGGATTCCTATGCAGCAGATGGGGGTTGTCTGTTTGTGCACTTTTTTCCTAAGCTGCTGAAATTCCTCCGATGTGAATGGG CCATAGTAATCTTTGCCTCCTGCGTGACTGTAAGCATGGCCTCCAGTGGATCAGAGAAAGCAGCTCAGTGATTGTTCTCATGGCCAAAAA TAAAGCACAAGGGTTACCGGAATTGAATGAGCCCTGTTCAGGGCAGCACGGGGCATCTGCACCCCAGCTGGGCAGCATGATCCTTGTATT CAACTATACTCTTCTGGCAGTAGTTGGTGGCAAGCATTCGCGTGCCTCTGTCACAACCATACGTAGAAACACATTAGGTATGTCTGGAAA GCTACAAATCCCACATCCAAGCACAGTACCGTCTGCTTCATCTGATTAACACACACACAAGAAAGAAAAATTACACCCACAGAAAACTGA GTATGTATTGTAGAAATGTAGAGGAAAAATAAAAATATTTTTTCAAATGTAATTACTTTTAATATATGCTTGTGGAAGGTCTAATACAAT GTATGCTGTCTCTGTAATTTTTGCTGTAAATAACTGGAGACGGTGAGTACACTGATTTTTCTATGTCTCTGTTTAAGCATAAGACTTTGT AACAATTTTTTTAGAGGGGGAAAATCAACAAAGAGCAAATATGTACTTGCTTCCTTTCTGCGTGTTATGTACTTCTCAGTTTTTTAATGG AAACTGGTTGTAACAGTTTAAGCATCTTGACGGGTCATTGGTGTTAAGTGTATGCTTCTTTTTGTAATATGACTGAGAAAGGGACAGGGC TGTCAATTAAATCTGCTCCAAAGAATTTGTATTGAAGATTGGCCTAAGACCTGCAAACTCCATCTATAACTAGAAAATACGAAAAAGGAA AATTAAAAAAAAAAGTTGCCTGAGTTAAGTCATCTTTCCTTGTAGCAAATGGCTTTGTCCAAATCCTTTCTGCATGGAATAGCTTAAGGA AAACAAACTCCGCTTTCTGATGAACAAGATATTTTTGTACACATTTATTTCTTGTTAATAACCTGAGGTCAGACCACTCATTTGCTGAAG CCATAACTGACCTTCACCAAATAAATGTTGTAAAGAACCTAGGGGAGGGTTGGGGAGAGACTGAGAGGGAGGAAAATCCAAGGTGTCATG AGCTATAGCAACACAGGCAGGAGCAAGTTGTTGAAACTGATGCTTTTCCTGCATCCCAAATATGACTTTAAAAGGCTAGTATTTTATGAT GATCGATTTATAATGATAAAAAGATATTTAGATTTAAATGAGACATTCCAATATTTTTGAAATCCCTAACAATGCTTCCTTGCTTTTAGG ATTGAGAGAAATGATTTTCATATACTTCCAACATTCAGAGATTTAATGTTTTTACCTTAGCTCCAGCCTACGCTTGTAAAGTGAAGAGTG ATTCTAAGTCCCGTGAAACCGTGGGCTGCCTGGGGCTTGGCTGTGCCCACTAACCTACTGCGCCTGGGGGGCAGCATGGGAGGGGTACAG TTTGCATCTCATTAGCATGCACACCACTGTTGGCAATGCATAAAAGTTGCATTGCCACAAGTATGTAAAATAAAAATATTCACTCTAAAA AGAATAATAATTCTACTTTTTTAAAAGAATAATGTCTCTTATAGTCACCATTGATTTTTCTGGAGTTTAATTACATTATTACCATGTATT CTTATTGGCCTGTAGAGGAAAAAGGCAAACCACAAATAAACCCAGTGACATATATAGTTTTAAAATCTACAATTTTCTGATCTCTCTCTC CTTGTTTAATATATAAGCCCTAATTTCTGTGTATGTGAGTAAAACTGCAGCCTGAGTCATTTAGGAAGTAAGTATTGAGTTTTTTTAATC ATAAATATACTAGAATAAAACAGCACTCCCTAACAATTAAAAAAGAGTTTTATATTACTTTAGAATGTAATAGGTTTTTGTCCTTATTTT ATGTCCTGTAAATTATTAGTTCAATACTGTTAGCATTCCCGGATAATGCACACATGATTTCTGAATGTTTTCTGTAAATGACAATCAATG >57528_57528_3_NCAM2-RORB_NCAM2_chr21_22370936_ENST00000400546_RORB_chr9_77245198_ENST00000376896_length(amino acids)=477AA_BP=20 MNMSLLLSFYLLGLLVSSGQAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLA LGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQ PSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQS KSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEA FDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQ -------------------------------------------------------------- >57528_57528_4_NCAM2-RORB_NCAM2_chr21_22370936_ENST00000400546_RORB_chr9_77245198_ENST00000396204_length(transcript)=3260nt_BP=304nt GCTGCCGCCGCGGCGGCCGCTGCTGCTGCTGCTTCTGCCGCCGCTGCCGCCGCCGCTGCCTGGATATAGTGCGGCAAGAGCGGAGCTTGC AGTCACTTTGCGAGGAGGAGCGCGCGGGCTGCGGGCGGCTGGGGCACCGCGGGAGCGGCGGCGGCGGCTCTAGCAGAGGCGGCCGGGGCA GCGAAAGGTTCTCTCTCCAGGGCTGGACTTAATAACTTTGAAACTGTCCACCGGTGTCACGTCCTGAACATGAGCCTCCTCCTCTCCTTC TACCTGCTGGGGTTGCTTGTCAGTAGCGGGCAAGCACAAATTGAAGTGATACCATGCAAAATTTGTGGCGATAAGTCCTCTGGGATCCAC TACGGAGTCATCACATGTGAAGGCTGCAAGGGATTCTTTAGGAGGAGCCAGCAGAACAATGCTTCTTATTCCTGCCCAAGGCAGAGAAAC TGTTTAATTGACAGAACGAACAGAAACCGTTGCCAACACTGCCGACTGCAGAAGTGTCTTGCCCTAGGAATGTCAAGAGATGCTGTGAAG TTTGGGAGGATGTCCAAGAAGCAAAGGGACAGCCTGTATGCTGAGGTGCAGAAGCACCAGCAGCGGCTGCAGGAACAGCGGCAGCAGCAG AGTGGGGAGGCAGAAGCCCTTGCCAGGGTGTACAGCAGCAGCATTAGCAACGGCCTGAGCAACCTGAACAACGAGACCAGCGGCACTTAT GCCAACGGGCACGTCATTGACCTGCCCAAGTCTGAGGGTTATTACAACGTCGATTCCGGTCAGCCGTCCCCTGATCAGTCAGGACTTGAC ATGACTGGAATCAAACAGATAAAGCAAGAACCTATCTATGACCTCACATCCGTACCCAACTTGTTTACCTATAGCTCTTTCAACAATGGG CAGTTAGCACCAGGGATAACCATGACTGAAATCGACCGAATTGCACAGAACATCATTAAGTCCCATTTGGAGACATGTCAATACACCATG GAAGAGCTGCACCAGCTGGCGTGGCAGACCCACACCTATGAAGAAATTAAAGCATATCAAAGCAAGTCCAGGGAAGCACTGTGGCAACAA TGTGCCATCCAGATCACTCACGCCATCCAATACGTGGTGGAGTTTGCAAAGCGGATAACAGGCTTCATGGAGCTCTGTCAAAATGATCAA ATTCTACTTCTGAAGTCAGGTTGCTTGGAAGTGGTTTTAGTGAGAATGTGCCGTGCCTTCAACCCATTAAACAACACTGTTCTGTTTGAA GGAAAATATGGAGGAATGCAAATGTTCAAAGCCTTAGGTTCTGATGACCTAGTGAATGAAGCATTTGACTTTGCAAAGAATTTGTGTTCC TTGCAGCTGACCGAGGAGGAGATCGCTTTGTTCTCATCTGCTGTTCTGATATCTCCAGACCGAGCCTGGCTTATAGAACCAAGGAAAGTC CAGAAGCTTCAGGAAAAAATTTATTTTGCACTTCAACATGTGATTCAGAAGAATCACCTGGATGATGAGACCTTGGCAAAGTTAATAGCC AAGATACCAACCATCACGGCAGTTTGCAACTTGCACGGGGAGAAGCTGCAGGTATTTAAGCAATCTCATCCAGAGATAGTGAATACACTG TTTCCTCCGTTATACAAGGAGCTCTTTAATCCTGACTGTGCCACCGGCTGCAAATGAAGGGGACAAGAGAACTGTCTCATAGTCATGGAA TGCATCACCATTAAGACAAAAGCAATGTGTTCATGAAGACTTAAGAAAAATGTCACTACTGCAACATTAGGAATGTCCTGCACTTAATAG AATTATTTTTCACCGCTACAGTTTGAAGAATGTAAATATGCACCTGAGTGGGGCTCTTTTATTTGTTTGTTTGTTTTTGAAATGACCATA AATATACAAATATAGGACACTGGGTGTTATCCTTTTTTTAATTTTATTCGGGTATGTTTTGGGAGACAACTGTTTATAGAATTTTATTGT AGATATATACAAGAAAAGAGCGGTACTTTACATGATTACTTTTCCTGTTGATTGTTCAAATATAATTTAAGAAAATTCCACTTAATAGGC TTACCTATTTCTATGTTTTTAGGTAGTTGATGCATGTGTAAATTTGTAGCTGTCTTGGAAAGTACTGTGCATGTATGTAATAAGTATATA ATATGTGAGAATATTATATATGACTATTACTTATACATGCACATGCACTGTGGCTTAAATACCATACCTACTAGCAATGGAGGTTCAGTC AGGCTCTCTTCTATGATTTACCTTCTGTGTTATATGTTACCTTTATGTTAGACAATCAGGATTTTGTTTTCCCAGCCAGAGTTTTCATCT ATAGTCAATGGCAGGACGGTACCAACTCAGAGTTAAGTCTACAAAGGAATAAACATAATGTGTGGCCTCTATATACAAACTCTATTTCTG TCAATGACATCAAAGCCTTGTCAAGATGGTTCATATTGGGAAGGAGACAGTATTTTAAGCCATTTTCCTGTTTCAAGAATTAGGCCACAG ATAACATTGCAAGGTCCAAGACTTTTTTGACCAAACAGTAGATATTTTCTATTTTTCACCAGAACACATAAAAACACTTTTTTTCTTTTG GATTTCTGGTTGTGAAACAAGCTTGATTTCAGTGCTTATTGTGTCTTCAACTGAAAAATACAATCTGTGGATTATGACTACCAGCAATTT TTTTCTAGGAAAGTTAAAAGAATAAATCAGAACCCAGGGCAACAATGCCATTTCATGTAAACATTTTCTCTCTCACCATGTTTTGGCAAG AAAAGGTAGAAAGAGAAGACCCAGAGTGAAGAAGTAATTCTTTATATTCCTTTCTTTAATGTATTTGTTAGGAAAAGTGGCAATAAAGGG GGAGGCATATTATAAAATGCTATAATATAAAAATGTAGCAAAAACTTGACAGACTAGAAAAAAAAAGATCTGTGTTATTCTAGGGAACTA ATGTACCCCAAAGCCAAAACTAATTCCTGTGAAGTTTACAGTTACATCATCCATTTACCCTAGAATTATTTTTTTAGCAACTTTTAGAAA TAAAGAATACAACTGTGACATTAGGATCAGAGATTTTAGACTTCCTTGTACAAATTCTCACTTCTCCACCTGCTCACCAATGAAATTAAT CATAAGAAAAGCATATATTCCAAGAAATTTGTTCTGCCTGTGTCCTGGAGGCCTATACCTCTGTTATTTTCTGATACAAAATAAAACTTA >57528_57528_4_NCAM2-RORB_NCAM2_chr21_22370936_ENST00000400546_RORB_chr9_77245198_ENST00000396204_length(amino acids)=477AA_BP=20 MNMSLLLSFYLLGLLVSSGQAQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLA LGMSRDAVKFGRMSKKQRDSLYAEVQKHQQRLQEQRQQQSGEAEALARVYSSSISNGLSNLNNETSGTYANGHVIDLPKSEGYYNVDSGQ PSPDQSGLDMTGIKQIKQEPIYDLTSVPNLFTYSSFNNGQLAPGITMTEIDRIAQNIIKSHLETCQYTMEELHQLAWQTHTYEEIKAYQS KSREALWQQCAIQITHAIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAFNPLNNTVLFEGKYGGMQMFKALGSDDLVNEA FDFAKNLCSLQLTEEEIALFSSAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQVFKQ -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NCAM2-RORB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NCAM2-RORB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NCAM2-RORB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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