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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NCAPG2-N4BP2 (FusionGDB2 ID:57550)

Fusion Gene Summary for NCAPG2-N4BP2

Fusion gene summary

Fusion gene information	Fusion gene name: NCAPG2-N4BP2
	Fusion gene ID: 57550
		Hgene	Tgene
	Gene symbol	NCAPG2	N4BP2
	Gene ID	54892	55728
	Gene name	non-SMC condensin II complex subunit G2	NEDD4 binding protein 2
	Synonyms	3KS\|CAP-G2\|CAPG2\|LUZP5\|MTB\|hCAP-G2	B3BP
	Cytomap	7q36.3	4p14
	Type of gene	protein-coding	protein-coding
	Description	condensin-2 complex subunit G2chromosome-associated protein G2leucine zipper protein 5more than blood homolog	NEDD4-binding protein 2BCL-3-binding protein
	Modification date	20200320	20200313
	UniProtAcc	Q86XI2	Q92802
	Ensembl transtripts involved in fusion gene	ENST00000356309, ENST00000409339, ENST00000409423, ENST00000449727, ENST00000275830, ENST00000479022, ENST00000541468,	ENST00000261435,
Fusion gene scores	* DoF score	6 X 5 X 6=180	8 X 9 X 2=144
	# samples	8	9
	** MAII score	log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NCAPG2 [Title/Abstract] AND N4BP2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NCAPG2(158494513)-N4BP2(40154400), # samples:2
Anticipated loss of major functional domain due to fusion event.	NCAPG2-N4BP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NCAPG2-N4BP2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NCAPG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across N4BP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E9-A1R6-01A	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+

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Fusion Gene ORF analysis for NCAPG2-N4BP2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000356309	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+
Frame-shift	ENST00000409339	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+
In-frame	ENST00000409423	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+
In-frame	ENST00000449727	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+
intron-3CDS	ENST00000275830	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+
intron-3CDS	ENST00000479022	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+
intron-3CDS	ENST00000541468	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000409423

NCAPG2

chr7

158494513

ENST00000261435

N4BP2

chr4

40154400

4436

251

1690

1259

143

ENST00000449727

NCAPG2

chr7

158494513

ENST00000261435

N4BP2

chr4

40154400

4398

213

1652

1221

143

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000409423	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+	0.8699947	0.13000529
ENST00000449727	ENST00000261435	NCAPG2	chr7	158494513	-	N4BP2	chr4	40154400	+	0.8726262	0.12737383

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Fusion Genomic Features for NCAPG2-N4BP2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NCAPG2	chr7	158494512	-	N4BP2	chr4	40154399	+	0.000389053	0.99961096
NCAPG2	chr7	158494512	-	N4BP2	chr4	40154399	+	0.000389053	0.99961096

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCAPG2-N4BP2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:158494513/chr4:40154400)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NCAPG2 Q86XI2	N4BP2 Q92802
FUNCTION: Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. {ECO:0000269\|PubMed:14532007, ECO:0000269\|PubMed:30609410}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NCAPG2

chr7:158494513

chr4:40154400

ENST00000356309

460_498

1144.0

Repeat

Note=HEAT

Hgene

NCAPG2

chr7:158494513

chr4:40154400

ENST00000409339

460_498

1157.0

Repeat

Note=HEAT

Hgene

NCAPG2

chr7:158494513

chr4:40154400

ENST00000409423

460_498

1144.0

Repeat

Note=HEAT

Hgene

NCAPG2

chr7:158494513

chr4:40154400

ENST00000449727

460_498

1157.0

Repeat

Note=HEAT

Tgene

N4BP2

chr7:158494513

chr4:40154400

ENST00000261435

218_259

1714

1771.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

N4BP2

chr7:158494513

chr4:40154400

ENST00000261435

90_177

1714

1771.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

N4BP2

chr7:158494513

chr4:40154400

ENST00000261435

328_368

1714

1771.0

Compositional bias

Note=Pro-rich

Tgene

N4BP2

chr7:158494513

chr4:40154400

ENST00000261435

1691_1770

1714

1771.0

Domain

Smr

Tgene

N4BP2

chr7:158494513

chr4:40154400

ENST00000261435

46_89

1714

1771.0

Domain

CUE

Tgene

N4BP2

chr7:158494513

chr4:40154400

ENST00000261435

447_454

1714

1771.0

Nucleotide binding

ATP

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Fusion Gene Sequence for NCAPG2-N4BP2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>57550_57550_1_NCAPG2-N4BP2_NCAPG2_chr7_158494513_ENST00000409423_N4BP2_chr4_40154400_ENST00000261435_length(transcript)=4436nt_BP=251nt
GAGGGCGGGGCCCGTCTGGGGCGCCGGCGGGTGCGTTTGAATCTGGTCCGAGCGCGGGAAACGGCGGGTCCCCGAGCCCAGTACCAGACC
TCCTGTGCGAAGAGTAACCTGCTCTTCGGACTGATAACTGGATGGGTTACAAAATAAATGCCATTTGAACAGTGCCATCTGTCATGGAAA
AACGTGAGACGTTTGTACAAGCCGTGTCTAAGGAGCTGGTTGGAGAGTTTTTGCAATTTGTTCAACTTGATAATTTAAGCAGAACGGTGG
GAAGCCCTATTTGTCTGTGATTACGGGGAGAGGAAACCACAGCCAGGGAGGAGTTGCTCGCATCAAACCAGCTGTCATTAAGTACCTCAT
AAGCCATAGCTTCAGGTTCTCTGAAATTAAACCAGGGTGCTTGAAAGTCATGCTAAAGTAAAATAAACATCCTTGAATTAGAAGTATGAA
GGTTTGTAGGTTAAAATTACTTTTATTTGCAGTAATTCAGTCAATTCTACCCTAAAGATGTGTTTTATTATAAATAATATTCAATTATGA
AACAAAAAAATTATGATGTTTTTCAAAATGCAAGTGAGGTTTGATTTTTTACTGAATCAAATGCAAATGTTACCTGTTAAAGATATTACA
GAGAAATTTTATTGATTACAAAATATGTAAGAAAATTATCAGCTACAGTTTTAAAGTTTAAAATGCTCTGATTGTTTCTCAGAAAAGGTT
ACCTTTGTATTAATTGTTGTATGACATTTAGTAATGTCCTAAAAGTCTTTTGTGAGAGGTATTTAAAGTGCTTTGAGACCTGATTCATGC
CCCCCAAAGGGTGGTATTAAAAGAGGAAAAAGGACATAGTAGTGGTAGTAAAGAAAAAAAGGAGATCTAACAAAAACACTTGAATATTTT
TTATTTTCAAAACTAAACACATAAAATGCTTTTATTTTGCCATATCCTACAGGAAGGAAGACATGCTTTTGCCCTTTCTTCTGCTTTGTA
TATGACCTTGATCTTTTACCTTTTGTTCTGTTCTTCTGTGTGCATTTTATGGAAAGAAAGTTGGGTCTGAGATTATATTGTAATTTTATA
CTTTCTATAGACAGAAAGGTTTTCAGAGAAAAAGAAATGGTTAAATATCTTCCAGATGTTGCTGCCTTATCGAAATGCTTCTAGAACTGT
CTGTATAAGTCGTATTTCAGACAGTACTAAATACTTATATTTTATTTTTGAGGCATGTAATTTTAAAACTGCAGTAGGTTAAAATTCTAT
TAAACAAATATAGAAAATATTTTGTTTATAATTGGCCTGGTGTGGTGGCCCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGT
GGATCGCCTGAGGTCAGAAGTTCAAGACCAGCCTGGCCAACATGGTGAATCCCCGTCTCTATTAAAAATACAAAAATTAGCTGGGTGTGG
TGGCGTGTGCCTGTAATCCCAGCTACTTGGGAGGCTGAGGCAGGAGAACCGCTTAAACCTGGGAGGTGGAGGTTGCAGTGACCCGAGATC
GAGATCACACCACTGCACTCAGCCTGGGTGACAGAGCAAGACTCCGTCTCCAAAAAAAAAAAAGAAAAAAAAGAGAAAATATTTTGGTTA
TAATCATAAGAAGAATCCTTACAATTTAAAATATTTTCACTTTTATTTTGAAAAAGAGCCAACTTTCTCAAAGGAAGCTGTCATTAACTT
CTGTTGTTTGGTTAGCTAATAAATTCTGTTAGTATGCAAGTTAAACCTGTGTAAAGGAGGTTATAATGTGGTAAGGTATAATTTTCCAAT
ATGAGACAATGGCTTAAATTTGCCTTTGGAGATGGAGAATATTTTCAACATACATAATTTTAACAAATAGTTTTGTTGCTTTTTGTTAAG
CTTAAAAAAAAATTTGGATCAGAAATTATAGGATTGAGCTGGTACCAAAAGAATCCTAAAGTACAGAATGGTTTTCCAAAAGAGCAGACA
TTTCAATGAAAATAAAACCCCAAAACATTTTTTTTATATATCATGATTGCATGCTTTTAAAATAAGGAGGCTTATCATTGAATTTTAGTT
CCATAAAAATGAAAATACATGTTTATTATTTAGAAATGGTTAGTGACTGGTATTGAAGTATTATTCACACTTATGTTTGTAATAATTTAT
TTAAAGAATGCCAACAGTTTAGCACACTTTTGTAATCTCTAGAACAGTTCTATACATTAAAAATAAACATTAAAAATAAAGCAGTTCCTT
TAAACAACTTACTATGAAACTATAATTGTTAATGAAATAAGATATTCCTATGTATACATTAGTATGATTTAAGGGTATGAAAAACAGTGC
TAAAATGTGGAGTTAATTGGAATGTGTGCAGCTGCATACTCACTTTCTGTGTTTTTATATTTCCTTACCTAGTTTTAAAAATCATCACTT
TTCGGCACTTCAGCTAGACTTATTTCAATATTATAATTATGATTAATGAAGGAGCAGTCAGAAGTAGAGGTGTGGTATTCCGTGGGCAGA
AGTCAAATGAAAAAAGCTATATTGTTTACTTGTTTACTATATCAATGTTAATATTATGCCTTATTTTGATAAATCAAATAGTATATCTTA
ATCATTGTTGATAAATATACAGGCAAAGTTTGAGCATCATATGTATTTTTATGAAGCTGCTTAATTCCAAATTGCCTCCCACCCCACTAT
CTAGCATAGTTTAAGCAACACATAATTTTGAAAGAAAAGTTTGTAATCCCTCCTTTCTTTTTTTTGCCCATTTCTAAATCCTGTATGCCC
GCAGTAAAGATAGTTTGGGGATTTTAAAAGTTTTCTCTATTACCCATTTCTAAATCCTGTATGTCAAAGATAGTTTGGAGATTATAAAAA
TTTTCATGTATTGGTGTAGGTTGAGTATCCCTAATGAGAAAATTCAAAATCTGAAATGCTTCAAAATCTGAAATTTTTCGAGCACAGACA
TGATGCTCAAAGGAAATACTCACAGAGCATTTTACATTTGTAGGTTAGCGATACTCAACAAGTAAATATAATGCACATGTTCTAAAATAT
CCCCCCAAACCCCAGCAATCCAAAACACTTCTGGTCCTAAGCATTTTGAGTAGGGGATACTCACTCAACCTGTATATTTGTGCTAATACA
TGACTCATTAGAATGATTCTTTGTAAACTTAATATTTTAAAAGTACAGCACTTCTGTAGTATGGAAGGTTTCAGTAATAATTATATTCAT
TCAGTAGTCTCTTACCATTATCTCCCAGATGGAAAAAGAGGACTAATGTGGAAACCCCAGAGGGTGTCCAGTTGGACCAGGGAGATATTA
GACACTTAACAGTATTTTCAGTCTGTCCATCTCTTTATTCCAATGTGAGAAATGGAAGTGTTTTTTTTTTTACGTTTATTGGCTCTTCAT
ATTTCTCTACATTATTTTTAATGTGCAGTTTCTTCAATTGGTTAGTATTTCCATACTATTTGCAACTTTATGGCCTTTAAATATAGGACA
TATTATATAGCAGAAATTTTGACTTTAAATCCTCTTGAGTAGTATATTTTGAGAAGAAAAGCTATACTGCTCTTCTGGATGGTTTCCATC
CTTTATTTAGGTCTTTTCTTTTTGAATTCAAGTGTTTTGTATGCTTAGAAAGTAGACATGTATAATATTGAGATCGGTTATTTCTGAGCT
GGAAATTGGAAACTTTGGAAACTCAGGAAATTGCTCTGACAATGTTTTAACTGCTCTCAATTTAAGAAAATGACGAAATGTATAAAAAAG
ACAAAAATAACGTGTGCTGTTTTTTCCAAGTGCTTTTTCTAAGTGCTTTTCCATTGTGCAATGAGGTGAAGTTTGGTAATTTTTCGGTGT
AGTAGTTAAATATTGCTCAATTTTTATTTACATGTAAAGAAAACAGATTTAAATGTTTATGTGGCCAAAAGGTGTCATTTAAAAGGTAAA
ATAAGTTTATGTAGAATGTATGTTCATGGTGCTTATTTTTAAAATGTAATTCAAGTTTACAGTATTACTTAATGCTTCTTTACAGAATTT
AATAGAGAAACAAGGCTAGAACACATCTACATCCTGAAGAGCCGTTTATAACTTCATATTATATGATGACAAAGTTCATTATTTTCCTTA
AAGTTGAGCAATTGACTTTTATGGTCCAATGATGAACTTATTATTAATAAATGATTGAGTTAACTGTGAGGCTTCTCATTAAAATACAAT
ATTGCAGCTATCAGTTGGAGAATATATTATAAAATTTTCAGACAGTATATCAGAAAAATGTTTTTATTTGTACTGTATAGAAAATGTAAT
TTTGCTGTTAACTCTGTACTTTTTAAATTGAAAATGTTTTATAAATTTGCTTTTAAATTTTCTTATGAAGCCATTTGCAAATTACATACT

>57550_57550_1_NCAPG2-N4BP2_NCAPG2_chr7_158494513_ENST00000409423_N4BP2_chr4_40154400_ENST00000261435_length(amino acids)=143AA_BP=30
MRKLALFQNKSENILNCKDSSYDYNQNIFSFFSFFFLETESCSVTQAECSGVISISGHCNLHLPGLSGSPASASQVAGITGTRHHTQLIF

--------------------------------------------------------------
>57550_57550_2_NCAPG2-N4BP2_NCAPG2_chr7_158494513_ENST00000449727_N4BP2_chr4_40154400_ENST00000261435_length(transcript)=4398nt_BP=213nt
GAATCTGGTCCGAGCGCGGGAAACGGCGGGTCCCCGAGCCCAGTACCAGACCTCCTGTGCGAAGAGTAACCTGCTCTTCGGACTGATAAC
TGGATGGGTTACAAAATAAATGCCATTTGAACAGTGCCATCTGTCATGGAAAAACGTGAGACGTTTGTACAAGCCGTGTCTAAGGAGCTG
GTTGGAGAGTTTTTGCAATTTGTTCAACTTGATAATTTAAGCAGAACGGTGGGAAGCCCTATTTGTCTGTGATTACGGGGAGAGGAAACC
ACAGCCAGGGAGGAGTTGCTCGCATCAAACCAGCTGTCATTAAGTACCTCATAAGCCATAGCTTCAGGTTCTCTGAAATTAAACCAGGGT
GCTTGAAAGTCATGCTAAAGTAAAATAAACATCCTTGAATTAGAAGTATGAAGGTTTGTAGGTTAAAATTACTTTTATTTGCAGTAATTC
AGTCAATTCTACCCTAAAGATGTGTTTTATTATAAATAATATTCAATTATGAAACAAAAAAATTATGATGTTTTTCAAAATGCAAGTGAG
GTTTGATTTTTTACTGAATCAAATGCAAATGTTACCTGTTAAAGATATTACAGAGAAATTTTATTGATTACAAAATATGTAAGAAAATTA
TCAGCTACAGTTTTAAAGTTTAAAATGCTCTGATTGTTTCTCAGAAAAGGTTACCTTTGTATTAATTGTTGTATGACATTTAGTAATGTC
CTAAAAGTCTTTTGTGAGAGGTATTTAAAGTGCTTTGAGACCTGATTCATGCCCCCCAAAGGGTGGTATTAAAAGAGGAAAAAGGACATA
GTAGTGGTAGTAAAGAAAAAAAGGAGATCTAACAAAAACACTTGAATATTTTTTATTTTCAAAACTAAACACATAAAATGCTTTTATTTT
GCCATATCCTACAGGAAGGAAGACATGCTTTTGCCCTTTCTTCTGCTTTGTATATGACCTTGATCTTTTACCTTTTGTTCTGTTCTTCTG
TGTGCATTTTATGGAAAGAAAGTTGGGTCTGAGATTATATTGTAATTTTATACTTTCTATAGACAGAAAGGTTTTCAGAGAAAAAGAAAT
GGTTAAATATCTTCCAGATGTTGCTGCCTTATCGAAATGCTTCTAGAACTGTCTGTATAAGTCGTATTTCAGACAGTACTAAATACTTAT
ATTTTATTTTTGAGGCATGTAATTTTAAAACTGCAGTAGGTTAAAATTCTATTAAACAAATATAGAAAATATTTTGTTTATAATTGGCCT
GGTGTGGTGGCCCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTAGGTGGATCGCCTGAGGTCAGAAGTTCAAGACCAGCCTGGCC
AACATGGTGAATCCCCGTCTCTATTAAAAATACAAAAATTAGCTGGGTGTGGTGGCGTGTGCCTGTAATCCCAGCTACTTGGGAGGCTGA
GGCAGGAGAACCGCTTAAACCTGGGAGGTGGAGGTTGCAGTGACCCGAGATCGAGATCACACCACTGCACTCAGCCTGGGTGACAGAGCA
AGACTCCGTCTCCAAAAAAAAAAAAGAAAAAAAAGAGAAAATATTTTGGTTATAATCATAAGAAGAATCCTTACAATTTAAAATATTTTC
ACTTTTATTTTGAAAAAGAGCCAACTTTCTCAAAGGAAGCTGTCATTAACTTCTGTTGTTTGGTTAGCTAATAAATTCTGTTAGTATGCA
AGTTAAACCTGTGTAAAGGAGGTTATAATGTGGTAAGGTATAATTTTCCAATATGAGACAATGGCTTAAATTTGCCTTTGGAGATGGAGA
ATATTTTCAACATACATAATTTTAACAAATAGTTTTGTTGCTTTTTGTTAAGCTTAAAAAAAAATTTGGATCAGAAATTATAGGATTGAG
CTGGTACCAAAAGAATCCTAAAGTACAGAATGGTTTTCCAAAAGAGCAGACATTTCAATGAAAATAAAACCCCAAAACATTTTTTTTATA
TATCATGATTGCATGCTTTTAAAATAAGGAGGCTTATCATTGAATTTTAGTTCCATAAAAATGAAAATACATGTTTATTATTTAGAAATG
GTTAGTGACTGGTATTGAAGTATTATTCACACTTATGTTTGTAATAATTTATTTAAAGAATGCCAACAGTTTAGCACACTTTTGTAATCT
CTAGAACAGTTCTATACATTAAAAATAAACATTAAAAATAAAGCAGTTCCTTTAAACAACTTACTATGAAACTATAATTGTTAATGAAAT
AAGATATTCCTATGTATACATTAGTATGATTTAAGGGTATGAAAAACAGTGCTAAAATGTGGAGTTAATTGGAATGTGTGCAGCTGCATA
CTCACTTTCTGTGTTTTTATATTTCCTTACCTAGTTTTAAAAATCATCACTTTTCGGCACTTCAGCTAGACTTATTTCAATATTATAATT
ATGATTAATGAAGGAGCAGTCAGAAGTAGAGGTGTGGTATTCCGTGGGCAGAAGTCAAATGAAAAAAGCTATATTGTTTACTTGTTTACT
ATATCAATGTTAATATTATGCCTTATTTTGATAAATCAAATAGTATATCTTAATCATTGTTGATAAATATACAGGCAAAGTTTGAGCATC
ATATGTATTTTTATGAAGCTGCTTAATTCCAAATTGCCTCCCACCCCACTATCTAGCATAGTTTAAGCAACACATAATTTTGAAAGAAAA
GTTTGTAATCCCTCCTTTCTTTTTTTTGCCCATTTCTAAATCCTGTATGCCCGCAGTAAAGATAGTTTGGGGATTTTAAAAGTTTTCTCT
ATTACCCATTTCTAAATCCTGTATGTCAAAGATAGTTTGGAGATTATAAAAATTTTCATGTATTGGTGTAGGTTGAGTATCCCTAATGAG
AAAATTCAAAATCTGAAATGCTTCAAAATCTGAAATTTTTCGAGCACAGACATGATGCTCAAAGGAAATACTCACAGAGCATTTTACATT
TGTAGGTTAGCGATACTCAACAAGTAAATATAATGCACATGTTCTAAAATATCCCCCCAAACCCCAGCAATCCAAAACACTTCTGGTCCT
AAGCATTTTGAGTAGGGGATACTCACTCAACCTGTATATTTGTGCTAATACATGACTCATTAGAATGATTCTTTGTAAACTTAATATTTT
AAAAGTACAGCACTTCTGTAGTATGGAAGGTTTCAGTAATAATTATATTCATTCAGTAGTCTCTTACCATTATCTCCCAGATGGAAAAAG
AGGACTAATGTGGAAACCCCAGAGGGTGTCCAGTTGGACCAGGGAGATATTAGACACTTAACAGTATTTTCAGTCTGTCCATCTCTTTAT
TCCAATGTGAGAAATGGAAGTGTTTTTTTTTTTACGTTTATTGGCTCTTCATATTTCTCTACATTATTTTTAATGTGCAGTTTCTTCAAT
TGGTTAGTATTTCCATACTATTTGCAACTTTATGGCCTTTAAATATAGGACATATTATATAGCAGAAATTTTGACTTTAAATCCTCTTGA
GTAGTATATTTTGAGAAGAAAAGCTATACTGCTCTTCTGGATGGTTTCCATCCTTTATTTAGGTCTTTTCTTTTTGAATTCAAGTGTTTT
GTATGCTTAGAAAGTAGACATGTATAATATTGAGATCGGTTATTTCTGAGCTGGAAATTGGAAACTTTGGAAACTCAGGAAATTGCTCTG
ACAATGTTTTAACTGCTCTCAATTTAAGAAAATGACGAAATGTATAAAAAAGACAAAAATAACGTGTGCTGTTTTTTCCAAGTGCTTTTT
CTAAGTGCTTTTCCATTGTGCAATGAGGTGAAGTTTGGTAATTTTTCGGTGTAGTAGTTAAATATTGCTCAATTTTTATTTACATGTAAA
GAAAACAGATTTAAATGTTTATGTGGCCAAAAGGTGTCATTTAAAAGGTAAAATAAGTTTATGTAGAATGTATGTTCATGGTGCTTATTT
TTAAAATGTAATTCAAGTTTACAGTATTACTTAATGCTTCTTTACAGAATTTAATAGAGAAACAAGGCTAGAACACATCTACATCCTGAA
GAGCCGTTTATAACTTCATATTATATGATGACAAAGTTCATTATTTTCCTTAAAGTTGAGCAATTGACTTTTATGGTCCAATGATGAACT
TATTATTAATAAATGATTGAGTTAACTGTGAGGCTTCTCATTAAAATACAATATTGCAGCTATCAGTTGGAGAATATATTATAAAATTTT
CAGACAGTATATCAGAAAAATGTTTTTATTTGTACTGTATAGAAAATGTAATTTTGCTGTTAACTCTGTACTTTTTAAATTGAAAATGTT

>57550_57550_2_NCAPG2-N4BP2_NCAPG2_chr7_158494513_ENST00000449727_N4BP2_chr4_40154400_ENST00000261435_length(amino acids)=143AA_BP=30
MRKLALFQNKSENILNCKDSSYDYNQNIFSFFSFFFLETESCSVTQAECSGVISISGHCNLHLPGLSGSPASASQVAGITGTRHHTQLIF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NCAPG2-N4BP2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NCAPG2-N4BP2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NCAPG2-N4BP2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source