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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCAPH2-GEMIN2 (FusionGDB2 ID:57553)

Fusion Gene Summary for NCAPH2-GEMIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: NCAPH2-GEMIN2
Fusion gene ID: 57553
HgeneTgene
Gene symbol

NCAPH2

GEMIN2

Gene ID

29781

8487

Gene namenon-SMC condensin II complex subunit H2gem nuclear organelle associated protein 2
SynonymsCAPH2SIP1|SIP1-delta
Cytomap

22q13.33

14q21.1

Type of geneprotein-codingprotein-coding
Descriptioncondensin-2 complex subunit H2CAP-H2 subunit of the condensin II complexCTA-384D8.36chromosome-associated protein H2kleisin betagem-associated protein 2SMN interacting protein 1-deltacomponent of gems 2gemin-2survival of motor neuron protein interacting protein 1
Modification date2020031320200322
UniProtAcc

Q6IBW4

O14893

Ensembl transtripts involved in fusion geneENST00000299821, ENST00000395698, 
ENST00000395701, ENST00000420993, 
ENST00000520297, 		ENST00000250379, 
ENST00000308317, ENST00000396249, 
Fusion gene scores* DoF score5 X 6 X 3=906 X 7 X 4=168
# samples 57
** MAII scorelog2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCAPH2 [Title/Abstract] AND GEMIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCAPH2(50954977)-GEMIN2(39601161), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGEMIN2

GO:0000387

spliceosomal snRNP assembly

18984161


check buttonFusion gene breakpoints across NCAPH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GEMIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GYNCAPH2chr22

50954977

+GEMIN2chr14

39601161

+


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Fusion Gene ORF analysis for NCAPH2-GEMIN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000299821ENST00000250379NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000299821ENST00000308317NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000299821ENST00000396249NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000395698ENST00000250379NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000395698ENST00000308317NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000395698ENST00000396249NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000395701ENST00000250379NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000395701ENST00000308317NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000395701ENST00000396249NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000420993ENST00000250379NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000420993ENST00000308317NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
In-frameENST00000420993ENST00000396249NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
intron-3CDSENST00000520297ENST00000250379NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
intron-3CDSENST00000520297ENST00000308317NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+
intron-3CDSENST00000520297ENST00000396249NCAPH2chr22

50954977

+GEMIN2chr14

39601161

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420993NCAPH2chr2250954977+ENST00000308317GEMIN2chr1439601161+1036332122541139
ENST00000420993NCAPH2chr2250954977+ENST00000396249GEMIN2chr1439601161+500332122451109
ENST00000420993NCAPH2chr2250954977+ENST00000250379GEMIN2chr1439601161+838332122541139
ENST00000395698NCAPH2chr2250954977+ENST00000308317GEMIN2chr1439601161+100930595514139
ENST00000395698NCAPH2chr2250954977+ENST00000396249GEMIN2chr1439601161+47330595424109
ENST00000395698NCAPH2chr2250954977+ENST00000250379GEMIN2chr1439601161+81130595514139
ENST00000395701NCAPH2chr2250954977+ENST00000308317GEMIN2chr1439601161+100830494513139
ENST00000395701NCAPH2chr2250954977+ENST00000396249GEMIN2chr1439601161+47230494423109
ENST00000395701NCAPH2chr2250954977+ENST00000250379GEMIN2chr1439601161+81030494513139
ENST00000299821NCAPH2chr2250954977+ENST00000308317GEMIN2chr1439601161+99228878497139
ENST00000299821NCAPH2chr2250954977+ENST00000396249GEMIN2chr1439601161+45628878407109
ENST00000299821NCAPH2chr2250954977+ENST00000250379GEMIN2chr1439601161+79428878497139

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420993ENST00000308317NCAPH2chr2250954977+GEMIN2chr1439601161+0.0037007950.9962992
ENST00000420993ENST00000396249NCAPH2chr2250954977+GEMIN2chr1439601161+0.0166777840.98332226
ENST00000420993ENST00000250379NCAPH2chr2250954977+GEMIN2chr1439601161+0.0041029740.99589705
ENST00000395698ENST00000308317NCAPH2chr2250954977+GEMIN2chr1439601161+0.0029629640.99703705
ENST00000395698ENST00000396249NCAPH2chr2250954977+GEMIN2chr1439601161+0.0123287420.98767126
ENST00000395698ENST00000250379NCAPH2chr2250954977+GEMIN2chr1439601161+0.0027675750.9972324
ENST00000395701ENST00000308317NCAPH2chr2250954977+GEMIN2chr1439601161+0.002676910.9973231
ENST00000395701ENST00000396249NCAPH2chr2250954977+GEMIN2chr1439601161+0.0116399750.98836005
ENST00000395701ENST00000250379NCAPH2chr2250954977+GEMIN2chr1439601161+0.0024816540.9975184
ENST00000299821ENST00000308317NCAPH2chr2250954977+GEMIN2chr1439601161+0.0029147340.9970853
ENST00000299821ENST00000396249NCAPH2chr2250954977+GEMIN2chr1439601161+0.0134004880.98659956
ENST00000299821ENST00000250379NCAPH2chr2250954977+GEMIN2chr1439601161+0.0030711160.9969289

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Fusion Genomic Features for NCAPH2-GEMIN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCAPH2chr2250954977+GEMIN2chr1439601161+0.0088663930.99113363
NCAPH2chr2250954977+GEMIN2chr1439601161+0.0088663930.99113363

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCAPH2-GEMIN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:50954977/chr14:39601161)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCAPH2

Q6IBW4

GEMIN2

O14893

FUNCTION: Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture (PubMed:14532007). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (By similarity). Seems to have lineage-specific role in T-cell development (PubMed:14532007). {ECO:0000250|UniProtKB:Q8BSP2, ECO:0000269|PubMed:14532007}.FUNCTION: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:9323129}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGEMIN2chr22:50954977chr14:39601161ENST0000025037959101_106196266.0Compositional biasNote=Poly-Gln
TgeneGEMIN2chr22:50954977chr14:39601161ENST00000308317610101_106211281.0Compositional biasNote=Poly-Gln
TgeneGEMIN2chr22:50954977chr14:39601161ENST0000039624969101_106211251.0Compositional biasNote=Poly-Gln


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Fusion Gene Sequence for NCAPH2-GEMIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57553_57553_1_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000299821_GEMIN2_chr14_39601161_ENST00000250379_length(transcript)=794nt_BP=288nt
AACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCCCGGACATGGAGGACGTG
GAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCCAGCTGGGCGAGTATCTG
GAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGTTGATCCAGGGCTCTGCC
TGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGGCTCATTCACTGATTCGG
CAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCAAAGATGATGAGAGGGTTCCTGCTTTGAATTTATTAATCTGCTTG
GTTAGCAGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTTGATGTAGCTGATCTCTCAGGGATAGAAGATATTTCTCATGAAGG
CAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCAACACATCTTCAACACTATGTGAAGGGTTCACATCTTAACCTGTG
CAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAAATATCAATGGAAAATCCCACTCAGTTTTTGATGAACAGTTTGAA

>57553_57553_1_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000299821_GEMIN2_chr14_39601161_ENST00000250379_length(amino acids)=139AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

--------------------------------------------------------------
>57553_57553_2_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000299821_GEMIN2_chr14_39601161_ENST00000308317_length(transcript)=992nt_BP=288nt
AACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCCCGGACATGGAGGACGTG
GAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCCAGCTGGGCGAGTATCTG
GAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGTTGATCCAGGGCTCTGCC
TGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGGCTCATTCACTGATTCGG
CAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCAAAGATGATGAGAGGGTTCCTGCTTTGAATTTATTAATCTGCTTG
GTTAGCAGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTTGATGTAGCTGATCTCTCAGGGATAGAAGATATTTCTCATGAAGG
CAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCAACACATCTTCAACACTATGTGAAGGGTTCACATCTTAACCTGTG
CAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAAATATCAATGGAAAATCCCACTCAGTTTTTGATGAACAGTTTGAA
CAGTTTTCTGTAATCAAGCAGCTTGCATAGAAATTGTATGATGAAATTTTACATAGGTTCTTGGTGCTGTTTTGTTCTTTTTTTGTTTTT
TGTTGTTTTGTTATTTACTTATATACATATAAAATTTTATTGAAAATATGTTTTGGTTACTAAAATTTTGTTTGACTCCTAACAAAAGAC
AATGGATGGCCTTAGCATCAGAATTAAAATAATCTGGATTAAATGGCAATGTGTTCATAGTCAGCAATAAAATTAAACATTTTTCCCTTT

>57553_57553_2_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000299821_GEMIN2_chr14_39601161_ENST00000308317_length(amino acids)=139AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

--------------------------------------------------------------
>57553_57553_3_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000299821_GEMIN2_chr14_39601161_ENST00000396249_length(transcript)=456nt_BP=288nt
AACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCCCGGACATGGAGGACGTG
GAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCCAGCTGGGCGAGTATCTG
GAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGTTGATCCAGGGCTCTGCC
TGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGGCTCATTCACTGATTCGG
CAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTTGATGTAGCTGATC

>57553_57553_3_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000299821_GEMIN2_chr14_39601161_ENST00000396249_length(amino acids)=109AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

--------------------------------------------------------------
>57553_57553_4_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395698_GEMIN2_chr14_39601161_ENST00000250379_length(transcript)=811nt_BP=305nt
CAGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCC
CGGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCC
AGCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGT
TGATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGG
CTCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCAAAGATGATGAGAGGGTTCCTGCTTTGA
ATTTATTAATCTGCTTGGTTAGCAGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTTGATGTAGCTGATCTCTCAGGGATAGAA
GATATTTCTCATGAAGGCAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCAACACATCTTCAACACTATGTGAAGGGT
TCACATCTTAACCTGTGCAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAAATATCAATGGAAAATCCCACTCAGTTT
TTGATGAACAGTTTGAACAGTTTTCTGTAATCAAGCAGCTTGCATAGAAATTGTATGATGAAATTTTACATAGGTTCTTGGTGCTGTTTT

>57553_57553_4_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395698_GEMIN2_chr14_39601161_ENST00000250379_length(amino acids)=139AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

--------------------------------------------------------------
>57553_57553_5_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395698_GEMIN2_chr14_39601161_ENST00000308317_length(transcript)=1009nt_BP=305nt
CAGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCC
CGGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCC
AGCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGT
TGATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGG
CTCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCAAAGATGATGAGAGGGTTCCTGCTTTGA
ATTTATTAATCTGCTTGGTTAGCAGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTTGATGTAGCTGATCTCTCAGGGATAGAA
GATATTTCTCATGAAGGCAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCAACACATCTTCAACACTATGTGAAGGGT
TCACATCTTAACCTGTGCAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAAATATCAATGGAAAATCCCACTCAGTTT
TTGATGAACAGTTTGAACAGTTTTCTGTAATCAAGCAGCTTGCATAGAAATTGTATGATGAAATTTTACATAGGTTCTTGGTGCTGTTTT
GTTCTTTTTTTGTTTTTTGTTGTTTTGTTATTTACTTATATACATATAAAATTTTATTGAAAATATGTTTTGGTTACTAAAATTTTGTTT
GACTCCTAACAAAAGACAATGGATGGCCTTAGCATCAGAATTAAAATAATCTGGATTAAATGGCAATGTGTTCATAGTCAGCAATAAAAT

>57553_57553_5_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395698_GEMIN2_chr14_39601161_ENST00000308317_length(amino acids)=139AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

--------------------------------------------------------------
>57553_57553_6_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395698_GEMIN2_chr14_39601161_ENST00000396249_length(transcript)=473nt_BP=305nt
CAGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCC
CGGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCC
AGCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGT
TGATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGG
CTCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGTATTTTGACCAACGTGATTTAGCTGATGAGCCA

>57553_57553_6_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395698_GEMIN2_chr14_39601161_ENST00000396249_length(amino acids)=109AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

--------------------------------------------------------------
>57553_57553_7_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395701_GEMIN2_chr14_39601161_ENST00000250379_length(transcript)=810nt_BP=304nt
AGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCCC
GGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCCA
GCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGTT
GATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGGC
TCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCAAAGATGATGAGAGGGTTCCTGCTTTGAA
TTTATTAATCTGCTTGGTTAGCAGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTTGATGTAGCTGATCTCTCAGGGATAGAAG
ATATTTCTCATGAAGGCAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCAACACATCTTCAACACTATGTGAAGGGTT
CACATCTTAACCTGTGCAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAAATATCAATGGAAAATCCCACTCAGTTTT
TGATGAACAGTTTGAACAGTTTTCTGTAATCAAGCAGCTTGCATAGAAATTGTATGATGAAATTTTACATAGGTTCTTGGTGCTGTTTTG

>57553_57553_7_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395701_GEMIN2_chr14_39601161_ENST00000250379_length(amino acids)=139AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

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>57553_57553_8_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395701_GEMIN2_chr14_39601161_ENST00000308317_length(transcript)=1008nt_BP=304nt
AGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCCC
GGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCCA
GCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGTT
GATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGGC
TCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCAAAGATGATGAGAGGGTTCCTGCTTTGAA
TTTATTAATCTGCTTGGTTAGCAGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTTGATGTAGCTGATCTCTCAGGGATAGAAG
ATATTTCTCATGAAGGCAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCAACACATCTTCAACACTATGTGAAGGGTT
CACATCTTAACCTGTGCAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAAATATCAATGGAAAATCCCACTCAGTTTT
TGATGAACAGTTTGAACAGTTTTCTGTAATCAAGCAGCTTGCATAGAAATTGTATGATGAAATTTTACATAGGTTCTTGGTGCTGTTTTG
TTCTTTTTTTGTTTTTTGTTGTTTTGTTATTTACTTATATACATATAAAATTTTATTGAAAATATGTTTTGGTTACTAAAATTTTGTTTG
ACTCCTAACAAAAGACAATGGATGGCCTTAGCATCAGAATTAAAATAATCTGGATTAAATGGCAATGTGTTCATAGTCAGCAATAAAATT

>57553_57553_8_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395701_GEMIN2_chr14_39601161_ENST00000308317_length(amino acids)=139AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

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>57553_57553_9_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395701_GEMIN2_chr14_39601161_ENST00000396249_length(transcript)=472nt_BP=304nt
AGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCTGCGGTCCCTTTGCCGCCCGTTCCCTCCC
GGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCAAGAACTGGGAGGTGGACGTGGCGGCCCA
GCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCACAATGAACTTCATTGAGGCAGCGTTGTT
GATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTTGTCTTGAAAAGCCTTTGTTACCTGAGGC
TCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGTATTTTGACCAACGTGATTTAGCTGATGAGCCAT

>57553_57553_9_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000395701_GEMIN2_chr14_39601161_ENST00000396249_length(amino acids)=109AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

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>57553_57553_10_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000420993_GEMIN2_chr14_39601161_ENST00000250379_length(transcript)=838nt_BP=332nt
GCGCCTACGCATTTTCCTGGGCGGGAACAGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCT
GCGGTCCCTTTGCCGCCCGTTCCCTCCCGGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCA
AGAACTGGGAGGTGGACGTGGCGGCCCAGCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCA
CAATGAACTTCATTGAGGCAGCGTTGTTGATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTT
GTCTTGAAAAGCCTTTGTTACCTGAGGCTCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCA
AAGATGATGAGAGGGTTCCTGCTTTGAATTTATTAATCTGCTTGGTTAGCAGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTT
GATGTAGCTGATCTCTCAGGGATAGAAGATATTTCTCATGAAGGCAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCA
ACACATCTTCAACACTATGTGAAGGGTTCACATCTTAACCTGTGCAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAA
ATATCAATGGAAAATCCCACTCAGTTTTTGATGAACAGTTTGAACAGTTTTCTGTAATCAAGCAGCTTGCATAGAAATTGTATGATGAAA

>57553_57553_10_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000420993_GEMIN2_chr14_39601161_ENST00000250379_length(amino acids)=139AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

--------------------------------------------------------------
>57553_57553_11_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000420993_GEMIN2_chr14_39601161_ENST00000308317_length(transcript)=1036nt_BP=332nt
GCGCCTACGCATTTTCCTGGGCGGGAACAGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCT
GCGGTCCCTTTGCCGCCCGTTCCCTCCCGGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCA
AGAACTGGGAGGTGGACGTGGCGGCCCAGCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCA
CAATGAACTTCATTGAGGCAGCGTTGTTGATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTT
GTCTTGAAAAGCCTTTGTTACCTGAGGCTCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGATAGCA
AAGATGATGAGAGGGTTCCTGCTTTGAATTTATTAATCTGCTTGGTTAGCAGGTATTTTGACCAACGTGATTTAGCTGATGAGCCATCTT
GATGTAGCTGATCTCTCAGGGATAGAAGATATTTCTCATGAAGGCAGCCTAACTCTGAGGAAAACAATGCCAATTCAAGTACAGATTTCA
ACACATCTTCAACACTATGTGAAGGGTTCACATCTTAACCTGTGCAATTCAGATTGATACTCAGAATATGGGTTGATTTGAATATCTGAA
ATATCAATGGAAAATCCCACTCAGTTTTTGATGAACAGTTTGAACAGTTTTCTGTAATCAAGCAGCTTGCATAGAAATTGTATGATGAAA
TTTTACATAGGTTCTTGGTGCTGTTTTGTTCTTTTTTTGTTTTTTGTTGTTTTGTTATTTACTTATATACATATAAAATTTTATTGAAAA
TATGTTTTGGTTACTAAAATTTTGTTTGACTCCTAACAAAAGACAATGGATGGCCTTAGCATCAGAATTAAAATAATCTGGATTAAATGG

>57553_57553_11_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000420993_GEMIN2_chr14_39601161_ENST00000308317_length(amino acids)=139AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

--------------------------------------------------------------
>57553_57553_12_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000420993_GEMIN2_chr14_39601161_ENST00000396249_length(transcript)=500nt_BP=332nt
GCGCCTACGCATTTTCCTGGGCGGGAACAGCAAAATGGCGCCAGAACTAGTGGCGGGCTGAGGACGCCGTACCCCTCGGAAGGCAGCCCT
GCGGTCCCTTTGCCGCCCGTTCCCTCCCGGACATGGAGGACGTGGAGGCGCGCTTCGCCCACCTCTTGCAGCCCATCCGCGACCTCACCA
AGAACTGGGAGGTGGACGTGGCGGCCCAGCTGGGCGAGTATCTGGAGGAGCTGGATCAGATCTGCATTTCTTTTGACGAAGGCAAGACCA
CAATGAACTTCATTGAGGCAGCGTTGTTGATCCAGGGCTCTGCCTGCGTCTACAGTAAGAAGGGAAGATGGCTTTATGCTTTATTGGCTT
GTCTTGAAAAGCCTTTGTTACCTGAGGCTCATTCACTGATTCGGCAGCTTGCAAGAAGGTGCTCTGAAGTGAGGCTCTTAGTGGTATTTT

>57553_57553_12_NCAPH2-GEMIN2_NCAPH2_chr22_50954977_ENST00000420993_GEMIN2_chr14_39601161_ENST00000396249_length(amino acids)=109AA_BP=70
MEDVEARFAHLLQPIRDLTKNWEVDVAAQLGEYLEELDQICISFDEGKTTMNFIEAALLIQGSACVYSKKGRWLYALLACLEKPLLPEAH

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Fusion Gene PPI Analysis for NCAPH2-GEMIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCAPH2-GEMIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCAPH2-GEMIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource