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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCEH1-EEF1G (FusionGDB2 ID:57580)

Fusion Gene Summary for NCEH1-EEF1G

check button Fusion gene summary
Fusion gene informationFusion gene name: NCEH1-EEF1G
Fusion gene ID: 57580
HgeneTgene
Gene symbol

NCEH1

EEF1G

Gene ID

57552

1937

Gene nameneutral cholesterol ester hydrolase 1eukaryotic translation elongation factor 1 gamma
SynonymsAADACL1|NCEHEF1G|GIG35
Cytomap

3q26.31

11q12.3

Type of geneprotein-codingprotein-coding
Descriptionneutral cholesterol ester hydrolase 1acetylalkylglycerol acetylhydrolasealkylacetylglycerol acetylhydrolasearylacetamide deacetylase-like 1elongation factor 1-gammaEF-1-gammaPRO1608eEF-1B gammapancreatic tumor-related proteintranslation elongation factor eEF-1 gamma chain
Modification date2020031320200313
UniProtAcc

Q6PIU2

P26641

Ensembl transtripts involved in fusion geneENST00000273512, ENST00000475381, 
ENST00000538775, ENST00000543711, 
ENST00000532986, ENST00000329251, 
ENST00000378019, 
Fusion gene scores* DoF score10 X 5 X 7=3509 X 9 X 6=486
# samples 1117
** MAII scorelog2(11/350*10)=-1.66985139830767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/486*10)=-1.51542156746808
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCEH1 [Title/Abstract] AND EEF1G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCEH1(172428637)-EEF1G(62327309), # samples:2
Anticipated loss of major functional domain due to fusion event.NCEH1-EEF1G seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NCEH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EEF1G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-G4-6323-01ANCEH1chr3

172428637

-EEF1Gchr11

62327309

-
ChimerDB4COADTCGA-G4-6323NCEH1chr3

172428636

-EEF1Gchr11

62327309

-


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Fusion Gene ORF analysis for NCEH1-EEF1G

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000273512ENST00000532986NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
5CDS-intronENST00000273512ENST00000532986NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
5CDS-intronENST00000475381ENST00000532986NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
5CDS-intronENST00000475381ENST00000532986NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
5CDS-intronENST00000538775ENST00000532986NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
5CDS-intronENST00000538775ENST00000532986NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
5UTR-3CDSENST00000543711ENST00000329251NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
5UTR-3CDSENST00000543711ENST00000329251NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
5UTR-3CDSENST00000543711ENST00000378019NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
5UTR-3CDSENST00000543711ENST00000378019NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
5UTR-intronENST00000543711ENST00000532986NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
5UTR-intronENST00000543711ENST00000532986NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
Frame-shiftENST00000273512ENST00000378019NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
Frame-shiftENST00000273512ENST00000378019NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
Frame-shiftENST00000475381ENST00000378019NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
Frame-shiftENST00000475381ENST00000378019NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
Frame-shiftENST00000538775ENST00000378019NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
Frame-shiftENST00000538775ENST00000378019NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
In-frameENST00000273512ENST00000329251NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
In-frameENST00000273512ENST00000329251NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
In-frameENST00000475381ENST00000329251NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
In-frameENST00000475381ENST00000329251NCEH1chr3

172428636

-EEF1Gchr11

62327309

-
In-frameENST00000538775ENST00000329251NCEH1chr3

172428637

-EEF1Gchr11

62327309

-
In-frameENST00000538775ENST00000329251NCEH1chr3

172428636

-EEF1Gchr11

62327309

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000475381NCEH1chr3172428637-ENST00000329251EEF1Gchr1162327309-609372104607167
ENST00000273512NCEH1chr3172428637-ENST00000329251EEF1Gchr1162327309-609372104607167
ENST00000538775NCEH1chr3172428637-ENST00000329251EEF1Gchr1162327309-609372104607167
ENST00000475381NCEH1chr3172428636-ENST00000329251EEF1Gchr1162327309-609372104607167
ENST00000273512NCEH1chr3172428636-ENST00000329251EEF1Gchr1162327309-609372104607167
ENST00000538775NCEH1chr3172428636-ENST00000329251EEF1Gchr1162327309-609372104607167

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000475381ENST00000329251NCEH1chr3172428637-EEF1Gchr1162327309-0.081357430.91864264
ENST00000273512ENST00000329251NCEH1chr3172428637-EEF1Gchr1162327309-0.081357430.91864264
ENST00000538775ENST00000329251NCEH1chr3172428637-EEF1Gchr1162327309-0.081357430.91864264
ENST00000475381ENST00000329251NCEH1chr3172428636-EEF1Gchr1162327309-0.081357430.91864264
ENST00000273512ENST00000329251NCEH1chr3172428636-EEF1Gchr1162327309-0.081357430.91864264
ENST00000538775ENST00000329251NCEH1chr3172428636-EEF1Gchr1162327309-0.081357430.91864264

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Fusion Genomic Features for NCEH1-EEF1G


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCEH1-EEF1G


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:172428637/chr11:62327309)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCEH1

Q6PIU2

EEF1G

P26641

FUNCTION: Hydrolyzes 2-acetyl monoalkylglycerol ether, the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor (PubMed:17052608). May be responsible for cholesterol ester hydrolysis in macrophages (By similarity). Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds (By similarity). May contribute to cancer pathogenesis by promoting tumor cell migration (PubMed:17052608). {ECO:0000250|UniProtKB:Q8BLF1, ECO:0000269|PubMed:17052608}.FUNCTION: Probably plays a role in anchoring the complex to other cellular components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCEH1chr3:172428636chr11:62327309ENST00000475381-151_446409.0Topological domainCytoplasmic
HgeneNCEH1chr3:172428637chr11:62327309ENST00000475381-151_446409.0Topological domainCytoplasmic
HgeneNCEH1chr3:172428636chr11:62327309ENST00000475381-155_2546409.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneNCEH1chr3:172428637chr11:62327309ENST00000475381-155_2546409.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCEH1chr3:172428636chr11:62327309ENST00000475381-15113_11546409.0MotifInvolved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
HgeneNCEH1chr3:172428636chr11:62327309ENST00000543711-14113_1150276.0MotifInvolved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
HgeneNCEH1chr3:172428637chr11:62327309ENST00000475381-15113_11546409.0MotifInvolved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
HgeneNCEH1chr3:172428637chr11:62327309ENST00000543711-14113_1150276.0MotifInvolved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole
HgeneNCEH1chr3:172428636chr11:62327309ENST00000475381-1526_40846409.0Topological domainLumenal
HgeneNCEH1chr3:172428636chr11:62327309ENST00000543711-141_40276.0Topological domainCytoplasmic
HgeneNCEH1chr3:172428636chr11:62327309ENST00000543711-1426_4080276.0Topological domainLumenal
HgeneNCEH1chr3:172428637chr11:62327309ENST00000475381-1526_40846409.0Topological domainLumenal
HgeneNCEH1chr3:172428637chr11:62327309ENST00000543711-141_40276.0Topological domainCytoplasmic
HgeneNCEH1chr3:172428637chr11:62327309ENST00000543711-1426_4080276.0Topological domainLumenal
HgeneNCEH1chr3:172428636chr11:62327309ENST00000543711-145_250276.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneNCEH1chr3:172428637chr11:62327309ENST00000543711-145_250276.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneEEF1Gchr3:172428636chr11:62327309ENST00000329251810276_437385438.0DomainEF-1-gamma C-terminal
TgeneEEF1Gchr3:172428636chr11:62327309ENST000003292518102_87385438.0DomainNote=GST N-terminal
TgeneEEF1Gchr3:172428636chr11:62327309ENST0000032925181088_216385438.0DomainNote=GST C-terminal
TgeneEEF1Gchr3:172428637chr11:62327309ENST00000329251810276_437385438.0DomainEF-1-gamma C-terminal
TgeneEEF1Gchr3:172428637chr11:62327309ENST000003292518102_87385438.0DomainNote=GST N-terminal
TgeneEEF1Gchr3:172428637chr11:62327309ENST0000032925181088_216385438.0DomainNote=GST C-terminal


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Fusion Gene Sequence for NCEH1-EEF1G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57580_57580_1_NCEH1-EEF1G_NCEH1_chr3_172428636_ENST00000273512_EEF1G_chr11_62327309_ENST00000329251_length(transcript)=609nt_BP=372nt
AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC
TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG
GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG
GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT
GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG
CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT

>57580_57580_1_NCEH1-EEF1G_NCEH1_chr3_172428636_ENST00000273512_EEF1G_chr11_62327309_ENST00000329251_length(amino acids)=167AA_BP=89
MIGSWAYKKRVNEQLPRAESCRRSPGGIALSSLPARWRAEPGQDEVVLCPAHRPGGAGRLLRLHPAAWLRVRPLEADAAGRHFPGCTASA

--------------------------------------------------------------
>57580_57580_2_NCEH1-EEF1G_NCEH1_chr3_172428636_ENST00000475381_EEF1G_chr11_62327309_ENST00000329251_length(transcript)=609nt_BP=372nt
AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC
TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG
GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG
GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT
GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG
CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT

>57580_57580_2_NCEH1-EEF1G_NCEH1_chr3_172428636_ENST00000475381_EEF1G_chr11_62327309_ENST00000329251_length(amino acids)=167AA_BP=89
MIGSWAYKKRVNEQLPRAESCRRSPGGIALSSLPARWRAEPGQDEVVLCPAHRPGGAGRLLRLHPAAWLRVRPLEADAAGRHFPGCTASA

--------------------------------------------------------------
>57580_57580_3_NCEH1-EEF1G_NCEH1_chr3_172428636_ENST00000538775_EEF1G_chr11_62327309_ENST00000329251_length(transcript)=609nt_BP=372nt
AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC
TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG
GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG
GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT
GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG
CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT

>57580_57580_3_NCEH1-EEF1G_NCEH1_chr3_172428636_ENST00000538775_EEF1G_chr11_62327309_ENST00000329251_length(amino acids)=167AA_BP=89
MIGSWAYKKRVNEQLPRAESCRRSPGGIALSSLPARWRAEPGQDEVVLCPAHRPGGAGRLLRLHPAAWLRVRPLEADAAGRHFPGCTASA

--------------------------------------------------------------
>57580_57580_4_NCEH1-EEF1G_NCEH1_chr3_172428637_ENST00000273512_EEF1G_chr11_62327309_ENST00000329251_length(transcript)=609nt_BP=372nt
AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC
TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG
GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG
GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT
GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG
CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT

>57580_57580_4_NCEH1-EEF1G_NCEH1_chr3_172428637_ENST00000273512_EEF1G_chr11_62327309_ENST00000329251_length(amino acids)=167AA_BP=89
MIGSWAYKKRVNEQLPRAESCRRSPGGIALSSLPARWRAEPGQDEVVLCPAHRPGGAGRLLRLHPAAWLRVRPLEADAAGRHFPGCTASA

--------------------------------------------------------------
>57580_57580_5_NCEH1-EEF1G_NCEH1_chr3_172428637_ENST00000475381_EEF1G_chr11_62327309_ENST00000329251_length(transcript)=609nt_BP=372nt
AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC
TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG
GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG
GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT
GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG
CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT

>57580_57580_5_NCEH1-EEF1G_NCEH1_chr3_172428637_ENST00000475381_EEF1G_chr11_62327309_ENST00000329251_length(amino acids)=167AA_BP=89
MIGSWAYKKRVNEQLPRAESCRRSPGGIALSSLPARWRAEPGQDEVVLCPAHRPGGAGRLLRLHPAAWLRVRPLEADAAGRHFPGCTASA

--------------------------------------------------------------
>57580_57580_6_NCEH1-EEF1G_NCEH1_chr3_172428637_ENST00000538775_EEF1G_chr11_62327309_ENST00000329251_length(transcript)=609nt_BP=372nt
AGAGCAGCGACAGAGCCTTCCTCAAACCTGTAGTGACTGCCACACTTTGCAAGGACACCGTAGAGGGGGCATGTCCGCGCTCCAACTTCC
TCCCGACGCAGCCTCTGATTGGCTCCTGGGCTTATAAGAAACGCGTGAATGAGCAGCTGCCGCGGGCAGAAAGTTGCCGGAGGTCTCCGG
GTGGTATCGCCCTTTCCTCTTTGCCAGCCCGCTGGCGAGCCGAGCCAGGGCAAGATGAGGTCGTCCTGTGTCCTGCTCACCGCCCTGGTG
GCGCTGGCCGCCTATTACGTCTACATCCCGCTGCCTGGCTCCGTGTCCGACCCCTGGAAGCTGATGCTGCTGGACGCCACTTTCCGGGGT
GCACAGCAAGTGCTGAGTCCAGATTGGCAGGTGGACTACGAGTCATACACATGGCGGAAACTGGATCCTGGCAGCGAGGAGACCCAGACG
CTGGTTCGAGAGTACTTTTCCTGGGAGGGGGCCTTCCAGCATGTGGGCAAAGCCTTCAATCAGGGCAAGATCTTCAAGTGAACATCTCTT

>57580_57580_6_NCEH1-EEF1G_NCEH1_chr3_172428637_ENST00000538775_EEF1G_chr11_62327309_ENST00000329251_length(amino acids)=167AA_BP=89
MIGSWAYKKRVNEQLPRAESCRRSPGGIALSSLPARWRAEPGQDEVVLCPAHRPGGAGRLLRLHPAAWLRVRPLEADAAGRHFPGCTASA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NCEH1-EEF1G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCEH1-EEF1G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCEH1-EEF1G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource