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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCK1-IL20RB (FusionGDB2 ID:57597)

Fusion Gene Summary for NCK1-IL20RB

check button Fusion gene summary
Fusion gene informationFusion gene name: NCK1-IL20RB
Fusion gene ID: 57597
HgeneTgene
Gene symbol

NCK1

IL20RB

Gene ID

4690

53833

Gene nameNCK adaptor protein 1interleukin 20 receptor subunit beta
SynonymsNCK|NCKalpha|nck-1DIRS1|FNDC6|IL-20R2
Cytomap

3q22.3

3q22.3

Type of geneprotein-codingprotein-coding
Descriptioncytoplasmic protein NCK1NCK tyrosine kinaseSH2/SH3 adaptor protein NCK-alphamelanoma NCK proteinnon-catalytic region of tyrosine kinaseinterleukin-20 receptor subunit betaIL-20 receptor subunit betaIL-20R-betaIL-20RBfibronectin type III domain containing 6interleukin 20 receptor beta subunitinterleukin-20 receptor II
Modification date2020032720200313
UniProtAcc

P16333

Q6UXL0

Ensembl transtripts involved in fusion geneENST00000288986, ENST00000469404, 
ENST00000481752, 		ENST00000309741, 
ENST00000329582, ENST00000484501, 
Fusion gene scores* DoF score8 X 7 X 10=5606 X 6 X 7=252
# samples 1515
** MAII scorelog2(15/560*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/252*10)=-0.748461233004036
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCK1 [Title/Abstract] AND IL20RB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIL20RB(136714398)-NCK1(136646826), # samples:2
NCK1(136647069)-IL20RB(136699307), # samples:7
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCK1

GO:0033137

negative regulation of peptidyl-serine phosphorylation

14676213|16835242

HgeneNCK1

GO:0036493

positive regulation of translation in response to endoplasmic reticulum stress

14676213

HgeneNCK1

GO:0045944

positive regulation of transcription by RNA polymerase II

10026169

HgeneNCK1

GO:0060548

negative regulation of cell death

18835251

HgeneNCK1

GO:0070262

peptidyl-serine dephosphorylation

16835242

HgeneNCK1

GO:1902237

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

14676213

HgeneNCK1

GO:1903676

positive regulation of cap-dependent translational initiation

11959995

HgeneNCK1

GO:1903679

positive regulation of cap-independent translational initiation

11959995

HgeneNCK1

GO:1903898

negative regulation of PERK-mediated unfolded protein response

14676213

HgeneNCK1

GO:1903912

negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

14676213|16835242

HgeneNCK1

GO:1990441

negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

16835242


check buttonFusion gene breakpoints across NCK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IL20RB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A03YNCK1chr3

136647069

+IL20RBchr3

136708282

+
ChimerDB4CHOLTCGA-ZH-A8Y4-01ANCK1chr3

136581161

+IL20RBchr3

136699308

+
ChimerDB4ESCATCGA-IG-A51DNCK1chr3

136647069

+IL20RBchr3

136699307

+
ChimerDB4ESCATCGA-L5-A4OSNCK1chr3

136665137

+IL20RBchr3

136728954

+
ChimerDB4ESCATCGA-R6-A8W5NCK1chr3

136647069

+IL20RBchr3

136708282

+
ChimerDB4ESCATCGA-V5-A7RCNCK1chr3

136647069

+IL20RBchr3

136699307

+
ChimerDB4LGGTCGA-CS-4938NCK1chr3

136647069

+IL20RBchr3

136708282

+
ChimerDB4LGGTCGA-HT-7695NCK1chr3

136647069

+IL20RBchr3

136708282

+
ChimerDB4LIHCTCGA-DD-A1EENCK1chr3

136647069

+IL20RBchr3

136699307

+
ChimerDB4LUADTCGA-80-5611NCK1chr3

136647069

+IL20RBchr3

136699307

+
ChimerDB4LUSCTCGA-37-4135NCK1chr3

136581161

+IL20RBchr3

136699308

+
ChimerDB4LUSCTCGA-37-4135NCK1chr3

136581161

+IL20RBchr3

136714256

+
ChimerDB4LUSCTCGA-63-A5MHNCK1chr3

136647069

+IL20RBchr3

136728954

+
ChimerDB4OVTCGA-25-2393NCK1chr3

136647069

+IL20RBchr3

136699307

+
ChimerDB4PCPGTCGA-QR-A70PNCK1chr3

136647069

+IL20RBchr3

136699307

+
ChimerDB4SARCTCGA-IF-A4AJNCK1chr3

136647069

+IL20RBchr3

136708282

+


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Fusion Gene ORF analysis for NCK1-IL20RB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000288986ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136708282

+
5CDS-3UTRENST00000288986ENST00000309741NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-3UTRENST00000288986ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136728954

+
5CDS-3UTRENST00000288986ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136708282

+
5CDS-3UTRENST00000288986ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136708282

+
5CDS-3UTRENST00000469404ENST00000309741NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-3UTRENST00000481752ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136708282

+
5CDS-3UTRENST00000481752ENST00000309741NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-3UTRENST00000481752ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136728954

+
5CDS-3UTRENST00000481752ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136708282

+
5CDS-3UTRENST00000481752ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136708282

+
5CDS-5UTRENST00000288986ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136699307

+
5CDS-5UTRENST00000481752ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136699307

+
5CDS-intronENST00000288986ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136699307

+
5CDS-intronENST00000288986ENST00000329582NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-intronENST00000288986ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136728954

+
5CDS-intronENST00000288986ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136699307

+
5CDS-intronENST00000288986ENST00000484501NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-intronENST00000288986ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136728954

+
5CDS-intronENST00000469404ENST00000329582NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-intronENST00000469404ENST00000484501NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-intronENST00000481752ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136699307

+
5CDS-intronENST00000481752ENST00000329582NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-intronENST00000481752ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136728954

+
5CDS-intronENST00000481752ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136699307

+
5CDS-intronENST00000481752ENST00000484501NCK1chr3

136665137

+IL20RBchr3

136728954

+
5CDS-intronENST00000481752ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136728954

+
5UTR-5UTRENST00000288986ENST00000309741NCK1chr3

136581161

+IL20RBchr3

136699308

+
5UTR-5UTRENST00000481752ENST00000309741NCK1chr3

136581161

+IL20RBchr3

136699308

+
5UTR-intronENST00000288986ENST00000309741NCK1chr3

136581161

+IL20RBchr3

136714256

+
5UTR-intronENST00000288986ENST00000329582NCK1chr3

136581161

+IL20RBchr3

136699308

+
5UTR-intronENST00000288986ENST00000329582NCK1chr3

136581161

+IL20RBchr3

136714256

+
5UTR-intronENST00000288986ENST00000484501NCK1chr3

136581161

+IL20RBchr3

136699308

+
5UTR-intronENST00000288986ENST00000484501NCK1chr3

136581161

+IL20RBchr3

136714256

+
5UTR-intronENST00000481752ENST00000309741NCK1chr3

136581161

+IL20RBchr3

136714256

+
5UTR-intronENST00000481752ENST00000329582NCK1chr3

136581161

+IL20RBchr3

136699308

+
5UTR-intronENST00000481752ENST00000329582NCK1chr3

136581161

+IL20RBchr3

136714256

+
5UTR-intronENST00000481752ENST00000484501NCK1chr3

136581161

+IL20RBchr3

136699308

+
5UTR-intronENST00000481752ENST00000484501NCK1chr3

136581161

+IL20RBchr3

136714256

+
intron-3UTRENST00000469404ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136708282

+
intron-3UTRENST00000469404ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136728954

+
intron-3UTRENST00000469404ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136708282

+
intron-3UTRENST00000469404ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136708282

+
intron-5UTRENST00000469404ENST00000309741NCK1chr3

136581161

+IL20RBchr3

136699308

+
intron-5UTRENST00000469404ENST00000309741NCK1chr3

136647069

+IL20RBchr3

136699307

+
intron-intronENST00000469404ENST00000309741NCK1chr3

136581161

+IL20RBchr3

136714256

+
intron-intronENST00000469404ENST00000329582NCK1chr3

136581161

+IL20RBchr3

136699308

+
intron-intronENST00000469404ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136699307

+
intron-intronENST00000469404ENST00000329582NCK1chr3

136581161

+IL20RBchr3

136714256

+
intron-intronENST00000469404ENST00000329582NCK1chr3

136647069

+IL20RBchr3

136728954

+
intron-intronENST00000469404ENST00000484501NCK1chr3

136581161

+IL20RBchr3

136699308

+
intron-intronENST00000469404ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136699307

+
intron-intronENST00000469404ENST00000484501NCK1chr3

136581161

+IL20RBchr3

136714256

+
intron-intronENST00000469404ENST00000484501NCK1chr3

136647069

+IL20RBchr3

136728954

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NCK1-IL20RB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCK1chr3136647069+IL20RBchr3136728954+0.0045766490.9954234
NCK1chr3136647069+IL20RBchr3136699307+0.0001382230.9998617
NCK1chr3136665137+IL20RBchr3136728954+0.0001292620.9998708
NCK1chr3136581161+IL20RBchr3136699307+4.52E-060.99999547
NCK1chr3136647069+IL20RBchr3136708282+1.58E-060.99999845
NCK1chr3136647069+IL20RBchr3136708282+1.58E-060.99999845
NCK1chr3136581161+IL20RBchr3136714255+1.36E-070.9999999
NCK1chr3136647069+IL20RBchr3136728954+0.0045766490.9954234
NCK1chr3136647069+IL20RBchr3136699307+0.0001382230.9998617
NCK1chr3136665137+IL20RBchr3136728954+0.0001292620.9998708
NCK1chr3136581161+IL20RBchr3136699307+4.52E-060.99999547
NCK1chr3136647069+IL20RBchr3136708282+1.58E-060.99999845
NCK1chr3136647069+IL20RBchr3136708282+1.58E-060.99999845
NCK1chr3136581161+IL20RBchr3136714255+1.36E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCK1-IL20RB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:136714398/:136646826)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCK1

P16333

IL20RB

Q6UXL0

FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:16835242, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18835251, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:9430661}.FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NCK1-IL20RB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NCK1-IL20RB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCK1-IL20RB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCK1-IL20RB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource