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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCKAP5-LYPD1 (FusionGDB2 ID:57639)

Fusion Gene Summary for NCKAP5-LYPD1

check button Fusion gene summary
Fusion gene informationFusion gene name: NCKAP5-LYPD1
Fusion gene ID: 57639
HgeneTgene
Gene symbol

NCKAP5

LYPD1

Gene ID

344148

116372

Gene nameNCK associated protein 5LY6/PLAUR domain containing 1
SynonymsERIH1|ERIH2|NAP5LYPDC1|PHTS
Cytomap

2q21.2

2q21.2

Type of geneprotein-codingprotein-coding
Descriptionnck-associated protein 5NAP-5peripheral clock protein 2ly6/PLAUR domain-containing protein 1putative HeLa tumor suppressor
Modification date2020031320200313
UniProtAcc

O14513

Q8N2G4

Ensembl transtripts involved in fusion geneENST00000317721, ENST00000405974, 
ENST00000409213, ENST00000409261, 
ENST00000473859, 		ENST00000345008, 
ENST00000397463, 
Fusion gene scores* DoF score15 X 14 X 7=14703 X 5 X 3=45
# samples 196
** MAII scorelog2(19/1470*10)=-2.95174483139278
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/45*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCKAP5 [Title/Abstract] AND LYPD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLYPD1(133425973)-NCKAP5(133489624), # samples:3
NCKAP5(133887550)-LYPD1(133403853), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NCKAP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LYPD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-A6V3NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
ChimerDB4HNSCTCGA-CR-7395NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
ChimerDB4HNSCTCGA-CV-6942NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
ChimerDB4HNSCTCGA-CV-7250NCKAP5chr2

133887550

-LYPD1chr2

133403853

-


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Fusion Gene ORF analysis for NCKAP5-LYPD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000317721ENST00000345008NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
Frame-shiftENST00000317721ENST00000345008NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
Frame-shiftENST00000317721ENST00000345008NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
Frame-shiftENST00000317721ENST00000397463NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
Frame-shiftENST00000317721ENST00000397463NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
Frame-shiftENST00000317721ENST00000397463NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
Frame-shiftENST00000405974ENST00000345008NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
Frame-shiftENST00000405974ENST00000345008NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
Frame-shiftENST00000405974ENST00000345008NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
Frame-shiftENST00000405974ENST00000397463NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
Frame-shiftENST00000405974ENST00000397463NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
Frame-shiftENST00000405974ENST00000397463NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
Frame-shiftENST00000409213ENST00000345008NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
Frame-shiftENST00000409213ENST00000345008NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
Frame-shiftENST00000409213ENST00000397463NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
Frame-shiftENST00000409213ENST00000397463NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
Frame-shiftENST00000409261ENST00000345008NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
Frame-shiftENST00000409261ENST00000345008NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
Frame-shiftENST00000409261ENST00000397463NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
Frame-shiftENST00000409261ENST00000397463NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
In-frameENST00000409213ENST00000345008NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
In-frameENST00000409213ENST00000397463NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
In-frameENST00000409261ENST00000345008NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
In-frameENST00000409261ENST00000397463NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
intron-3CDSENST00000473859ENST00000345008NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
intron-3CDSENST00000473859ENST00000345008NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
intron-3CDSENST00000473859ENST00000345008NCKAP5chr2

133554201

-LYPD1chr2

133403853

-
intron-3CDSENST00000473859ENST00000397463NCKAP5chr2

133971288

-LYPD1chr2

133403853

-
intron-3CDSENST00000473859ENST00000397463NCKAP5chr2

133887550

-LYPD1chr2

133403853

-
intron-3CDSENST00000473859ENST00000397463NCKAP5chr2

133554201

-LYPD1chr2

133403853

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000409261NCKAP5chr2133887550-ENST00000397463LYPD1chr2133403853-214371519551389188
ENST00000409261NCKAP5chr2133887550-ENST00000345008LYPD1chr2133403853-1209715374844156
ENST00000409213NCKAP5chr2133887550-ENST00000397463LYPD1chr2133403853-214671819581392188
ENST00000409213NCKAP5chr2133887550-ENST00000345008LYPD1chr2133403853-1212718377847156

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409261ENST00000397463NCKAP5chr2133887550-LYPD1chr2133403853-0.039964790.9600352
ENST00000409261ENST00000345008NCKAP5chr2133887550-LYPD1chr2133403853-0.0753943850.92460555
ENST00000409213ENST00000397463NCKAP5chr2133887550-LYPD1chr2133403853-0.069485330.93051463
ENST00000409213ENST00000345008NCKAP5chr2133887550-LYPD1chr2133403853-0.0889770.911023

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Fusion Genomic Features for NCKAP5-LYPD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCKAP5-LYPD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:133425973/chr2:133489624)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCKAP5

O14513

LYPD1

Q8N2G4

FUNCTION: Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro increases receptor desensitization and decreases affinity for ACh of alpha-4:beta-2-containing nAChRs. May play a role in the intracellular trafficking of alpha-4:beta-2 and alpha-7-containing nAChRs and may inhibit their expression at the cell surface. May be involved in the control of anxiety. {ECO:0000250|UniProtKB:Q8BLC3}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLYPD1chr2:133887550chr2:133403853ENST000003450081325_1071190.0DomainNote=UPAR/Ly6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000317721-41871_2531131910.0Coiled coilOntology_term=ECO:0000255
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000405974-41671_253113591.0Coiled coilOntology_term=ECO:0000255
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000409213-61871_253113591.0Coiled coilOntology_term=ECO:0000255
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000409261-62071_2531131910.0Coiled coilOntology_term=ECO:0000255
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000317721-4181080_11301131910.0Compositional biasNote=Ser-rich
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000317721-418331_3861131910.0Compositional biasNote=Ser-rich
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000317721-418927_9331131910.0Compositional biasNote=Poly-Pro
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000405974-4161080_1130113591.0Compositional biasNote=Ser-rich
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000405974-416331_386113591.0Compositional biasNote=Ser-rich
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000405974-416927_933113591.0Compositional biasNote=Poly-Pro
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000409213-6181080_1130113591.0Compositional biasNote=Ser-rich
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000409213-618331_386113591.0Compositional biasNote=Ser-rich
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000409213-618927_933113591.0Compositional biasNote=Poly-Pro
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000409261-6201080_11301131910.0Compositional biasNote=Ser-rich
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000409261-620331_3861131910.0Compositional biasNote=Ser-rich
HgeneNCKAP5chr2:133887550chr2:133403853ENST00000409261-620927_9331131910.0Compositional biasNote=Poly-Pro
TgeneLYPD1chr2:133887550chr2:133403853ENST000003974631325_10763142.0DomainNote=UPAR/Ly6


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Fusion Gene Sequence for NCKAP5-LYPD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57639_57639_1_NCKAP5-LYPD1_NCKAP5_chr2_133887550_ENST00000409213_LYPD1_chr2_133403853_ENST00000345008_length(transcript)=1212nt_BP=718nt
GAAGCAACTACGGAGCCGCAGCCCAGGGAGCAAGTCTCCGCAAACTTGCTCCGCATTCACGGCAGGACTTCCCAGCCGCTGTGGATGTTC
AGGAAAACCGAGTCTGTTCTGTTAGCGTGGCCTTTGAATGCTTCAAAAATAAACAGAGGATAACCAACCGCGGGAGGAAATTTTTAGCTG
GAGAGAGTTGTAGTTCCTGTGTCTGTCTCCAGGACTGTGATATGTGTTGACTGAAGAGCTAACTACAAGTTCATCGTGAAGAATAAATGA
GATAAGCTACCTCAAGTGCCTGTACCAAAATAGACTCACAATACATTGACCCTGGAAACAGACGGGGGATTCTTATAAGTCACAAAAGAA
AATAAATAACTTCATCCATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAAT
ACATGGACTCCAATAAATACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCC
GACTACAGCGAGAAGTTGCCCAAAGAACAAGTGAGGGGGCCATGCATGAGAAGCTGATACATGAACTGGAAGAGGAGAGACACTTACGTC
TTCAAAGCGAGAAGCGGTTGCAGGAGGTGACCCTAGAGTCTGAACGCAACAGAATTCAGATGCGTAGCTTGCAGCAGCAGTTCTCCAGGG
ATCATGTACCGCAAGTCCTGTGCATCATCAGCGGCCTGTCTCATCGCCTCTGCCGGGTACCAGTCCTTCTGCTCCCCAGGGAAACTGAAC
TCAGTTTGCATCAGCTGCTGCAACACCCCTCTTTGTAACGGGCCAAGGCCCAAGAAAAGGGGAAGTTCTGCCTCGGCCCTCAGGCCAGGG
CTCCGCACCACCATCCTGTTCCTCAAATTAGCCCTCTTCTCGGCACACTGCTGAAGCTGAAGGAGATGCCACCCCCTCCTGCATTGTTCT
TCCAGCCCTCGCCCCCAACCCCCCACCTCCCTGAGTGAGTTTCTTCTGGGTGTCCTTTTATTCTGGGTAGGGAGCGGGAGTCCGTGTTCT
CTTTTGTTCCTGTGCAAATAATGAAAGAGCTCGGTAAAGCATTCTGAATAAATTCAGCCTGACTGAATTTTCAGTATGTACTTGAAGGAA

>57639_57639_1_NCKAP5-LYPD1_NCKAP5_chr2_133887550_ENST00000409213_LYPD1_chr2_133403853_ENST00000345008_length(amino acids)=156AA_BP=0
MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKR

--------------------------------------------------------------
>57639_57639_2_NCKAP5-LYPD1_NCKAP5_chr2_133887550_ENST00000409213_LYPD1_chr2_133403853_ENST00000397463_length(transcript)=2146nt_BP=718nt
GAAGCAACTACGGAGCCGCAGCCCAGGGAGCAAGTCTCCGCAAACTTGCTCCGCATTCACGGCAGGACTTCCCAGCCGCTGTGGATGTTC
AGGAAAACCGAGTCTGTTCTGTTAGCGTGGCCTTTGAATGCTTCAAAAATAAACAGAGGATAACCAACCGCGGGAGGAAATTTTTAGCTG
GAGAGAGTTGTAGTTCCTGTGTCTGTCTCCAGGACTGTGATATGTGTTGACTGAAGAGCTAACTACAAGTTCATCGTGAAGAATAAATGA
GATAAGCTACCTCAAGTGCCTGTACCAAAATAGACTCACAATACATTGACCCTGGAAACAGACGGGGGATTCTTATAAGTCACAAAAGAA
AATAAATAACTTCATCCATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAAT
ACATGGACTCCAATAAATACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCC
GACTACAGCGAGAAGTTGCCCAAAGAACAAGTGAGGGGGCCATGCATGAGAAGCTGATACATGAACTGGAAGAGGAGAGACACTTACGTC
TTCAAAGCGAGAAGCGGTTGCAGGAGGTGACCCTAGAGTCTGAACGCAACAGAATTCAGATGCGTAGCTTGCAGCAGCAGTTCTCCAGGG
ATCATGTACCGCAAGTCCTGTGCATCATCAGCGGCCTGTCTCATCGCCTCTGCCGGGTACCAGTCCTTCTGCTCCCCAGGGAAACTGAAC
TCAGTTTGCATCAGCTGCTGCAACACCCCTCTTTGTAACGGGCCAAGGCCCAAGAAAAGGGGAAGTTCTGCCTCGGCCCTCAGGCCAGGG
CTCCGCACCACCATCCTGTTCCTCAAATTAGCCCTCTTCTCGGCACACTGCTGAAGCTGAAGGAGATGCCACCCCCTCCTGCATTGTTCT
TCCAGCCCTCGCCCCCAACCCCCCACCTCCCTGAGTGAGTTTCTTCTGGGTGTCCTTTTATTCTGGGTAGGGAGCGGGAGTCCGTGTTCT
CTTTTGTTCCTGTGCAAATAATGAAAGAGCTCGGTAAAGCATTCTGAATAAATTCAGCCTGACTGAATTTTCAGTATGTACTTGAAGGAA
GGAGGTGGAGTGAAAGTTCACCCCCATGTCTGTGTAACCGGAGTCAAGGCCAGGCTGGCAGAGTCAGTCCTTAGAAGTCACTGAGGTGGG
CATCTGCCTTTTGTAAAGCCTCCAGTGTCCATTCCATCCCTGATGGGGGCATAGTTTGAGACTGCAGAGTGAGAGTGACGTTTTCTTAGG
GCTGGAGGGCCAGTTCCCACTCAAGGCTCCCTCGCTTGACATTCAAACTTCATGCTCCTGAAAACCATTCTCTGCAGCAGAATTGGCTGG
TTTCGCGCCTGAGTTGGGCTCTAGTGACTCGAGACTCAATGACTGGGACTTAGACTGGGGCTCGGCCTCGCTCTGAAAAGTGCTTAAGAA
AATCTTCTCAGTTCTCCTTGCAGAGGACTGGCGCCGGGACGCGAAGAGCAACGGGCGCTGCACAAAGCGGGCGCTGTCGGTGGTGGAGTG
CGCATGTACGCGCAGGCGCTTCTCGTGGTTGGCGTGCTGCAGCGACAGGCGGCAGCACAGCACCTGCACGAACACCCGCCGAAACTGCTG
CGAGGACACCGTGTACAGGAGCGGGTTGATGACCGAGCTGAGGTAGAAAAACGTCTCCGAGAAGGGGAGGAGGATCATGTACGCCCGGAA
GTAGGACCTCGTCCAGTCGTGCTTGGGTTTGGCCGCAGCCATGATCCTCCGAATCTGGTTGGGCATCCAGCATACGGCCAATGTCACAAC
AATCAGCCCTGGGCAGACACGAGCAGGAGGGAGAGACAGAGAAAAGAAAAACACAGCATGAGAACACAGTAAATGAATAAAACCATAAAA
TATTTAGCCCCTCTGTTCTGTGCTTACTGGCCAGGAAATGGTACCAATTTTTCAGTGTTGGACTTGACAGCTTCTTTTGCCACAAGCAAG

>57639_57639_2_NCKAP5-LYPD1_NCKAP5_chr2_133887550_ENST00000409213_LYPD1_chr2_133403853_ENST00000397463_length(amino acids)=188AA_BP=
MCSHAVFFFSLSLPPARVCPGLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVF
VQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAE

--------------------------------------------------------------
>57639_57639_3_NCKAP5-LYPD1_NCKAP5_chr2_133887550_ENST00000409261_LYPD1_chr2_133403853_ENST00000345008_length(transcript)=1209nt_BP=715nt
GCAACTACGGAGCCGCAGCCCAGGGAGCAAGTCTCCGCAAACTTGCTCCGCATTCACGGCAGGACTTCCCAGCCGCTGTGGATGTTCAGG
AAAACCGAGTCTGTTCTGTTAGCGTGGCCTTTGAATGCTTCAAAAATAAACAGAGGATAACCAACCGCGGGAGGAAATTTTTAGCTGGAG
AGAGTTGTAGTTCCTGTGTCTGTCTCCAGGACTGTGATATGTGTTGACTGAAGAGCTAACTACAAGTTCATCGTGAAGAATAAATGAGAT
AAGCTACCTCAAGTGCCTGTACCAAAATAGACTCACAATACATTGACCCTGGAAACAGACGGGGGATTCTTATAAGTCACAAAAGAAAAT
AAATAACTTCATCCATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACA
TGGACTCCAATAAATACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGAC
TACAGCGAGAAGTTGCCCAAAGAACAAGTGAGGGGGCCATGCATGAGAAGCTGATACATGAACTGGAAGAGGAGAGACACTTACGTCTTC
AAAGCGAGAAGCGGTTGCAGGAGGTGACCCTAGAGTCTGAACGCAACAGAATTCAGATGCGTAGCTTGCAGCAGCAGTTCTCCAGGGATC
ATGTACCGCAAGTCCTGTGCATCATCAGCGGCCTGTCTCATCGCCTCTGCCGGGTACCAGTCCTTCTGCTCCCCAGGGAAACTGAACTCA
GTTTGCATCAGCTGCTGCAACACCCCTCTTTGTAACGGGCCAAGGCCCAAGAAAAGGGGAAGTTCTGCCTCGGCCCTCAGGCCAGGGCTC
CGCACCACCATCCTGTTCCTCAAATTAGCCCTCTTCTCGGCACACTGCTGAAGCTGAAGGAGATGCCACCCCCTCCTGCATTGTTCTTCC
AGCCCTCGCCCCCAACCCCCCACCTCCCTGAGTGAGTTTCTTCTGGGTGTCCTTTTATTCTGGGTAGGGAGCGGGAGTCCGTGTTCTCTT
TTGTTCCTGTGCAAATAATGAAAGAGCTCGGTAAAGCATTCTGAATAAATTCAGCCTGACTGAATTTTCAGTATGTACTTGAAGGAAGGA

>57639_57639_3_NCKAP5-LYPD1_NCKAP5_chr2_133887550_ENST00000409261_LYPD1_chr2_133403853_ENST00000345008_length(amino acids)=156AA_BP=0
MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREVAQRTSEGAMHEKLIHELEEERHLRLQSEKR

--------------------------------------------------------------
>57639_57639_4_NCKAP5-LYPD1_NCKAP5_chr2_133887550_ENST00000409261_LYPD1_chr2_133403853_ENST00000397463_length(transcript)=2143nt_BP=715nt
GCAACTACGGAGCCGCAGCCCAGGGAGCAAGTCTCCGCAAACTTGCTCCGCATTCACGGCAGGACTTCCCAGCCGCTGTGGATGTTCAGG
AAAACCGAGTCTGTTCTGTTAGCGTGGCCTTTGAATGCTTCAAAAATAAACAGAGGATAACCAACCGCGGGAGGAAATTTTTAGCTGGAG
AGAGTTGTAGTTCCTGTGTCTGTCTCCAGGACTGTGATATGTGTTGACTGAAGAGCTAACTACAAGTTCATCGTGAAGAATAAATGAGAT
AAGCTACCTCAAGTGCCTGTACCAAAATAGACTCACAATACATTGACCCTGGAAACAGACGGGGGATTCTTATAAGTCACAAAAGAAAAT
AAATAACTTCATCCATGGAGGGAAAGAGACAGCTTGAGAAAAGGGACTTTGGAAAAAGGCTGTCTCTAGACAGCAGTCTTGTGGAATACA
TGGACTCCAATAAATACATTGAGCATCTGCTGACTCAGCTTGAGGAGCAACACAGGAGTCTCTGGAGGGAGAAGTTGGCAGTGGCCCGAC
TACAGCGAGAAGTTGCCCAAAGAACAAGTGAGGGGGCCATGCATGAGAAGCTGATACATGAACTGGAAGAGGAGAGACACTTACGTCTTC
AAAGCGAGAAGCGGTTGCAGGAGGTGACCCTAGAGTCTGAACGCAACAGAATTCAGATGCGTAGCTTGCAGCAGCAGTTCTCCAGGGATC
ATGTACCGCAAGTCCTGTGCATCATCAGCGGCCTGTCTCATCGCCTCTGCCGGGTACCAGTCCTTCTGCTCCCCAGGGAAACTGAACTCA
GTTTGCATCAGCTGCTGCAACACCCCTCTTTGTAACGGGCCAAGGCCCAAGAAAAGGGGAAGTTCTGCCTCGGCCCTCAGGCCAGGGCTC
CGCACCACCATCCTGTTCCTCAAATTAGCCCTCTTCTCGGCACACTGCTGAAGCTGAAGGAGATGCCACCCCCTCCTGCATTGTTCTTCC
AGCCCTCGCCCCCAACCCCCCACCTCCCTGAGTGAGTTTCTTCTGGGTGTCCTTTTATTCTGGGTAGGGAGCGGGAGTCCGTGTTCTCTT
TTGTTCCTGTGCAAATAATGAAAGAGCTCGGTAAAGCATTCTGAATAAATTCAGCCTGACTGAATTTTCAGTATGTACTTGAAGGAAGGA
GGTGGAGTGAAAGTTCACCCCCATGTCTGTGTAACCGGAGTCAAGGCCAGGCTGGCAGAGTCAGTCCTTAGAAGTCACTGAGGTGGGCAT
CTGCCTTTTGTAAAGCCTCCAGTGTCCATTCCATCCCTGATGGGGGCATAGTTTGAGACTGCAGAGTGAGAGTGACGTTTTCTTAGGGCT
GGAGGGCCAGTTCCCACTCAAGGCTCCCTCGCTTGACATTCAAACTTCATGCTCCTGAAAACCATTCTCTGCAGCAGAATTGGCTGGTTT
CGCGCCTGAGTTGGGCTCTAGTGACTCGAGACTCAATGACTGGGACTTAGACTGGGGCTCGGCCTCGCTCTGAAAAGTGCTTAAGAAAAT
CTTCTCAGTTCTCCTTGCAGAGGACTGGCGCCGGGACGCGAAGAGCAACGGGCGCTGCACAAAGCGGGCGCTGTCGGTGGTGGAGTGCGC
ATGTACGCGCAGGCGCTTCTCGTGGTTGGCGTGCTGCAGCGACAGGCGGCAGCACAGCACCTGCACGAACACCCGCCGAAACTGCTGCGA
GGACACCGTGTACAGGAGCGGGTTGATGACCGAGCTGAGGTAGAAAAACGTCTCCGAGAAGGGGAGGAGGATCATGTACGCCCGGAAGTA
GGACCTCGTCCAGTCGTGCTTGGGTTTGGCCGCAGCCATGATCCTCCGAATCTGGTTGGGCATCCAGCATACGGCCAATGTCACAACAAT
CAGCCCTGGGCAGACACGAGCAGGAGGGAGAGACAGAGAAAAGAAAAACACAGCATGAGAACACAGTAAATGAATAAAACCATAAAATAT
TTAGCCCCTCTGTTCTGTGCTTACTGGCCAGGAAATGGTACCAATTTTTCAGTGTTGGACTTGACAGCTTCTTTTGCCACAAGCAAGAGA

>57639_57639_4_NCKAP5-LYPD1_NCKAP5_chr2_133887550_ENST00000409261_LYPD1_chr2_133403853_ENST00000397463_length(amino acids)=188AA_BP=
MCSHAVFFFSLSLPPARVCPGLIVVTLAVCWMPNQIRRIMAAAKPKHDWTRSYFRAYMILLPFSETFFYLSSVINPLLYTVSSQQFRRVF
VQVLCCRLSLQHANHEKRLRVHAHSTTDSARFVQRPLLFASRRQSSARRTEKIFLSTFQSEAEPQSKSQSLSLESLEPNSGAKPANSAAE

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Fusion Gene PPI Analysis for NCKAP5-LYPD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCKAP5-LYPD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCKAP5-LYPD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource