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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCKIPSD-RIMKLB (FusionGDB2 ID:57650)

Fusion Gene Summary for NCKIPSD-RIMKLB

check button Fusion gene summary
Fusion gene informationFusion gene name: NCKIPSD-RIMKLB
Fusion gene ID: 57650
HgeneTgene
Gene symbol

NCKIPSD

RIMKLB

Gene ID

51517

57494

Gene nameNCK interacting protein with SH3 domainribosomal modification protein rimK like family member B
SynonymsAF3P21|DIP|DIP1|ORF1|SPIN90|VIP54|WASLBP|WISHFAM80B|NAAGS|NAAGS-I
Cytomap

3p21.31

12p13.31

Type of geneprotein-codingprotein-coding
DescriptionNCK-interacting protein with SH3 domain54 kDa VacA-interacting protein54 kDa vimentin-interacting protein90 kDa SH3 protein interacting with NckSH3 adapter protein SPIN90SH3 protein interacting with Nck, 90 kDaWASP-interacting SH3-domain proteindiabeta-citrylglutamate synthase BN-acetyl-aspartyl-glutamate synthetase BN-acetyl-aspartylglutamate synthetase BN-acetylaspartyl-glutamate synthetase BNAAG synthetase Bbeta-citryl-glutamate synthase Bfamily with sequence similarity 80, member Briboso
Modification date2020031320200313
UniProtAcc

Q9NZQ3

.
Ensembl transtripts involved in fusion geneENST00000294129, ENST00000341520, 
ENST00000416649, 		ENST00000299673, 
ENST00000538135, ENST00000357529, 
ENST00000535829, 
Fusion gene scores* DoF score4 X 4 X 4=647 X 7 X 5=245
# samples 49
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCKIPSD [Title/Abstract] AND RIMKLB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCKIPSD(48719477)-RIMKLB(8904552), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NCKIPSD (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RIMKLB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NNCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+


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Fusion Gene ORF analysis for NCKIPSD-RIMKLB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000294129ENST00000299673NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
5CDS-3UTRENST00000294129ENST00000538135NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
5CDS-3UTRENST00000341520ENST00000299673NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
5CDS-3UTRENST00000341520ENST00000538135NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
5CDS-3UTRENST00000416649ENST00000299673NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
5CDS-3UTRENST00000416649ENST00000538135NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
In-frameENST00000294129ENST00000357529NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
In-frameENST00000294129ENST00000535829NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
In-frameENST00000341520ENST00000357529NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
In-frameENST00000341520ENST00000535829NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
In-frameENST00000416649ENST00000357529NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+
In-frameENST00000416649ENST00000535829NCKIPSDchr3

48719477

-RIMKLBchr12

8904552

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341520NCKIPSDchr348719477-ENST00000535829RIMKLBchr128904552+2068692821446454
ENST00000341520NCKIPSDchr348719477-ENST00000357529RIMKLBchr128904552+4854692821446454
ENST00000416649NCKIPSDchr348719477-ENST00000535829RIMKLBchr128904552+2030654651408447
ENST00000416649NCKIPSDchr348719477-ENST00000357529RIMKLBchr128904552+4816654651408447
ENST00000294129NCKIPSDchr348719477-ENST00000535829RIMKLBchr128904552+20947181081472454
ENST00000294129NCKIPSDchr348719477-ENST00000357529RIMKLBchr128904552+48807181081472454

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341520ENST00000535829NCKIPSDchr348719477-RIMKLBchr128904552+0.0021647320.99783534
ENST00000341520ENST00000357529NCKIPSDchr348719477-RIMKLBchr128904552+0.000248670.99975127
ENST00000416649ENST00000535829NCKIPSDchr348719477-RIMKLBchr128904552+0.0018756770.9981243
ENST00000416649ENST00000357529NCKIPSDchr348719477-RIMKLBchr128904552+0.0002062360.9997938
ENST00000294129ENST00000535829NCKIPSDchr348719477-RIMKLBchr128904552+0.0019648370.99803513
ENST00000294129ENST00000357529NCKIPSDchr348719477-RIMKLBchr128904552+0.0002337660.9997663

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Fusion Genomic Features for NCKIPSD-RIMKLB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCKIPSDchr348719477-RIMKLBchr128904552+0.071772920.92822707
NCKIPSDchr348719477-RIMKLBchr128904552+0.071772920.92822707

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCKIPSD-RIMKLB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:48719477/chr12:8904552)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCKIPSD

Q9NZQ3

.
FUNCTION: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP-induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. {ECO:0000250, ECO:0000269|PubMed:22419821}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000294129-4131_58199723.0DomainSH3
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000341520-4131_58199723.0DomainSH3
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000416649-4131_58192716.0DomainSH3
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000294129-413175_192199723.0MotifNuclear localization signal
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000341520-413175_192199723.0MotifNuclear localization signal
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000416649-413175_192192716.0MotifNuclear localization signal
TgeneRIMKLBchr3:48719477chr12:8904552ENST0000035752937193_203135387.0Nucleotide bindingATP
TgeneRIMKLBchr3:48719477chr12:8904552ENST0000053582926193_203135387.0Nucleotide bindingATP
TgeneRIMKLBchr3:48719477chr12:8904552ENST0000053813526193_203135387.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000294129-413171_275199723.0Compositional biasNote=Pro-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000294129-413197_240199723.0Compositional biasNote=Ser/Thr-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000294129-413442_487199723.0Compositional biasNote=Leu-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000294129-413534_601199723.0Compositional biasNote=Leu-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000341520-413171_275199723.0Compositional biasNote=Pro-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000341520-413197_240199723.0Compositional biasNote=Ser/Thr-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000341520-413442_487199723.0Compositional biasNote=Leu-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000341520-413534_601199723.0Compositional biasNote=Leu-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000416649-413171_275192716.0Compositional biasNote=Pro-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000416649-413197_240192716.0Compositional biasNote=Ser/Thr-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000416649-413442_487192716.0Compositional biasNote=Leu-rich
HgeneNCKIPSDchr3:48719477chr12:8904552ENST00000416649-413534_601192716.0Compositional biasNote=Leu-rich
TgeneRIMKLBchr3:48719477chr12:8904552ENST0000035752937119_304135387.0DomainATP-grasp
TgeneRIMKLBchr3:48719477chr12:8904552ENST0000053582926119_304135387.0DomainATP-grasp
TgeneRIMKLBchr3:48719477chr12:8904552ENST0000053813526119_304135387.0DomainATP-grasp


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Fusion Gene Sequence for NCKIPSD-RIMKLB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57650_57650_1_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000294129_RIMKLB_chr12_8904552_ENST00000357529_length(transcript)=4880nt_BP=718nt
GCGCGCGCCTGCGTAGTGTGTCACGGGGCGGGACAACCGCGGCGCGGCTCGGCGCTCCCGGCCTGGCGTTGTGGCGCCGCAGCCCTTGCC
ACCTTCCCTGCACCTGCCCTGCCCGGCCTCATGTACCGCGCGCTGTACGCGTTCCGCTCGGCGGAGCCCAACGCGCTGGCGTTCGCCGCG
GGCGAGACCTTCCTGGTGCTAGAGCGAAGCAGCGCGCACTGGTGGCTGGCCGCGCGGGCGCGCAGTGGTGAGACGGGCTACGTGCCGCCA
GCCTACCTGCGCCGCCTGCAGGGCCTGGAGCAGGATGTCCTCCAGGCCATTGACCGGGCCATCGAGGCTGTACACAACACAGCCATGCGG
GATGGTGGCAAGTACAGCCTGGAACAGCGTGGAGTCCTCCAGAAGCTGATCCACCACCGGAAAGAGACCCTGTCACGCAGAGGCCCTTCA
GCCTCCAGTGTTGCAGTTATGACCTCATCAACCAGTGACCACCACTTGGATGCTGCTGCAGCCAGGCAGCCCAATGGGGTGTGTCGAGCT
GGGTTCGAGCGGCAGCACAGCCTACCCAGTTCTGAGCATCTTGGGGCAGATGGAGGCCTCTACCAGATCCCACTTCCATCTTCCCAGATC
CCACCACAGCCTCGCCGAGCAGCACCCACCACACCGCCCCCACCAGTGAAGCGCCGAGACCGCGAGGCCCTGATGGCCTCTGGGAGTGGT
GGCCACGAAAATTTTGCTAAAATGATTGATGAGGCTGAAGTTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAA
GCTGTTTTCTTGGCTCGAGATAAGCACCATTTGGCTGATCTAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTT
AAAGAGTCTCATGGACGGGATGTACGTGTCATTGTCGTGGGAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATG
CAAAGCAACTGCTCATTAGGTGGTGTGGGGATGATGTGCTCATTGAGTGAACAAGGGAAGCAGCTAGCTATCCAGGTGTCTAATATCCTG
GGGATGGATGTGTGTGGCATTGATCTGCTGATGAAAGATGACGGCTCCTTCTGCGTCTGTGAGGCCAATGCAAATGTAGGTTTCATCGCC
TTTGATAAGGCTTGTAATCTAGATGTAGCTGGTATCATAGCAGACTATGCCGCCTCCCTTCTACCCTCTGGCCGGCTCACCCGGCGTATG
TCCCTGCTCTCCGTGGTGTCCACTGCCAGTGAGACTAGTGAGCCGGAGCTGGGTCCCCCAGCCAGCACTGCTGTTGACAACATGAGTGCA
AGTTCCAGCTCTGTTGACAGCGACCCTGAAAGCACGGAGCGAGAGCTGCTCACCAAGCTCCCAGGGGGCCTGTTCAACATGAACCAGCTG
CTAGCCAATGAAATCAAACTACTGGTGGACTGACTCCACTGGTAATTAACCAACAAAACCCTTGTAAAACTTTCTTTCTTCTTTTCTATT
TTTAAAACCAACTTGCAATGCTGTTCATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGGATTAGTTGGAGAGAGTGGGAGATAGA
TGAGACCTCTGCTAGTAAGATGTTACTTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAGGTGGGGTATAGAAAAATGTCAGGCTC
TCATAGTTACCCTTTTAAATTGCTAAAAAATGTGTATGCTCATAGGCCATGAGGAACAAATACTTTTTTTTTTTCATGGTCCCTTGCTTT
TGTTTTTGTACAAAAAAAAATGGTTTTGCTACAAATATCCAAGTAGCATAACTTCACATTGTGTTGGAAGATTTGTCATCAGTGAGGAAA
ACATCTGCATAAATTACAGGAATTTTTGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTATTAACTAGCAGCTTTAGTTTGTAGTTT
ATGAAATCTTGAGGGGCTCTTTTACTGGGATTTCTTATTTTTTTGTTTTTTCCCGCTTAATTTGGTGGGAGGTCAAATTGAATATAACCC
AATAAAGGCTTCTTAATGACAAAATTGGCATGTTTGCATGATGAAATGGAAATGAACAGTATTGCAATGTCCGGTATACAAAATAACATT
AATTCAATGTAGATAAAATTACACTAGTTTAAAATATGTGCATTCACTTGTATTTGTTAGTGTTTTAGTCTTTTTTGAAAGATGTGCTCT
GTTAATGTTGCTTTTTTTTTTTTTTTTAATACATGCTAGTCTAACATTTCCTGCTCTATGCCTGCATCTTTAACAATGGCCAAAGTGAAG
AAAATGCTACCTTTTTTGTTAACAAGACACTGACTTGAAACATGTACATTTAAAGCCTTTTATTTTTTCCCTTTTTGTTTTGGTAGTTGG
GCATTTAAATAAGGACAAGGAAAAATATTTTTGGGGGCAAATCAAGAGCCTATGAGTTCTAAGTATAAAGCTGAAGTGATTTCGAATGCC
AGCGTTATATATTTGCATTTTTCACATTTTACGAGGGAGTATATGTGTATGTGTGTGCACGCATGCATGTGTATGTGTTTTGCTTTTTGT
TTCCATCAACTAATCAAAAAGGATAATTTAGAAAATGGAGCATGATGGGAAACAGAGTTTTTGACTTTAAAAAACAGATGAGTTGTTTTC
ATAAGTAGACTCCACTGGGGTAGAGGTATTCACCTTAAAACATAGGGTGAGTAGATGCTTTTTTAGGCCTTTTTGTGTATATGTACGTTG
TTTGTTTTTTTCCTTTTGTTTCTAGCCTGTTCAGTGTACAGTTTATTCAAGGCTACATGCTTTTCTTTAATGCTTCTGGCTATGCATTTT
CTCTTTTTACATATAGGATTTGGGATTGGGGGTGGGTTGGATGTTTTTGTTTGGGGACTTATTTAGTAGTATTGAGTCTCTTATAGCCCT
ACTCTTAAGCCTTCAATACTGTCCACTCTTTATATTCCTTTACTTGCAGAATTTATAAAAGCCCCCAAACTGCATATAATATGAGCCTTT
AAAACATGGGTAAAACTAATCCCATTGATGGGTTTGGATGGTATGTTAAGAAATGGAGATGCTGCAGAGCCCAACGTAATTTTTTAAACA
GCAAGTTTTCCATCTCCCTACGAATCCTCTGAAGCTTTTACCCAAGCCCTTTCTTGCCTCTCCAGTGCTATTTTCCTTCAGATGGACCTT
AAACATAATTTCTTGGACACTACTAGAGAGACTTCGAGGCAATAATAAAAGATCAGTATTAACCAGCTATAACAGAGGTTTGATCATGCT
TACTTGTACAGTTTTTCCCCCGTTTTAAAAAGGAATGTAATAAAATTTGTTTTTTCCATAGAATTAAATAATATTAAAATTGAGTGAAAG
GTTGATTGTTGATGAATAGAATAGTACCTCTCATCTGTGCAGTGTCTCATTTCACCTCAGAGAAAAGGATACATAAGAGGAGTTTGTAAT
TTATCTTAGGATATTCTAATTGCATTTAAAAGAACTTATCTTGCGCAGGGTAAATGGGGGACTCACATACATATATTAATACCTCTGACT
CATTAACAGAAAGAAATACTTGGTACTTCTTTCGCTGAATGACCATACTGTGGAGGATGCATACTATTTGGTATAGAGAAATAAATGAGG
AAGAAAGAACTGCTTAATTAAATTATCATTCATATGTTCATATAGAGACCATCTGGTTGCCATGTGTATTATGACACATACACTTTGAAT
AGTTACATATCACAAGTATGTAGTTCATGTTTGTGTTGGTGGGGTAAGGCATCAGGAAAAATGTAGTTAGTCTTTTCTTAACTTATACCA
AATTAACCAACTATATTATAGGAAATATGTGAAATTAGTTCATTAGCTTTATTCACTATTATGCATTCACATGATATTAAAACGTACACT
CACATGTTAGAATGAAAAGAGCAGTAGTTATCTTAGATTTTAAAAACATGGATATCTTCTTGAATTCCTTCAAGATTGAGGTAGAGAATA
AGAGCAAATCATTCTGGAAGTACCTTAAGGAAACAAACAGCAGCAGATATTTAGGTTAAACTTATTTTCATAATTGTTTAATAACTTTTG
TATAATCTTCATTGCTATTATGAGAGAGAATGTATATATCAAATATGTGTAATGATAAAATCTGAATTGTAAAATTTTTGTATATTGTTA
AAATTGTAATTCTAAATTGTATTTCAAAAATGATTATTTCTGATATTGTTTTTATGTCACCCATGATGAAAACTGGACTTTATATATCTA
AACATACAAGTATGAACTATTCTATTTAAAATTTTTAATAGTTTTTTTCTTTTTTGGTGCCTATAATTGATTGGTCATTTCTGCTGGCTT
TTCTCCAATGAACATTGAAATCTTCCTGTATATGTTACCAATAAGAAAACTACCCTGGAACAGTAGAAAAACCCAACAAGAGACTTGGCA
TTCATCAAGCACATTATCAGACTTTGAGAACATATTGAAGGCATTGACTTTGAAAATCATCTCTTTTTCTCAAGAAGAAAGCAATGGAGA
AGCAAATTTGTTTCATTCAGTGAATCCCCAGTTTGGGGCTTGTGGGGCTTAGAGACATTGTGAAATCAAATCTTGTGTTATACTTTTCTC
CTGGCTCACTTTTTTTGAGAAGGTTTATGGGCTATTTGGCTGGTGAGACACGATCCCCTCCTAAGAAAATGTAGGTGCTCAGACAGGTAA
CCACTGCTGCTACTGTTTTTATTTGTTTGTTTGTTCAATTTTATTTAAGATTTGTTTTTGTTGTACTAGGATTTTAAAAAATGTAATATA

>57650_57650_1_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000294129_RIMKLB_chr12_8904552_ENST00000357529_length(amino acids)=454AA_BP=203
MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS
LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRR
AAPTTPPPPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGR
DVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACN
LDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIK

--------------------------------------------------------------
>57650_57650_2_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000294129_RIMKLB_chr12_8904552_ENST00000535829_length(transcript)=2094nt_BP=718nt
GCGCGCGCCTGCGTAGTGTGTCACGGGGCGGGACAACCGCGGCGCGGCTCGGCGCTCCCGGCCTGGCGTTGTGGCGCCGCAGCCCTTGCC
ACCTTCCCTGCACCTGCCCTGCCCGGCCTCATGTACCGCGCGCTGTACGCGTTCCGCTCGGCGGAGCCCAACGCGCTGGCGTTCGCCGCG
GGCGAGACCTTCCTGGTGCTAGAGCGAAGCAGCGCGCACTGGTGGCTGGCCGCGCGGGCGCGCAGTGGTGAGACGGGCTACGTGCCGCCA
GCCTACCTGCGCCGCCTGCAGGGCCTGGAGCAGGATGTCCTCCAGGCCATTGACCGGGCCATCGAGGCTGTACACAACACAGCCATGCGG
GATGGTGGCAAGTACAGCCTGGAACAGCGTGGAGTCCTCCAGAAGCTGATCCACCACCGGAAAGAGACCCTGTCACGCAGAGGCCCTTCA
GCCTCCAGTGTTGCAGTTATGACCTCATCAACCAGTGACCACCACTTGGATGCTGCTGCAGCCAGGCAGCCCAATGGGGTGTGTCGAGCT
GGGTTCGAGCGGCAGCACAGCCTACCCAGTTCTGAGCATCTTGGGGCAGATGGAGGCCTCTACCAGATCCCACTTCCATCTTCCCAGATC
CCACCACAGCCTCGCCGAGCAGCACCCACCACACCGCCCCCACCAGTGAAGCGCCGAGACCGCGAGGCCCTGATGGCCTCTGGGAGTGGT
GGCCACGAAAATTTTGCTAAAATGATTGATGAGGCTGAAGTTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAA
GCTGTTTTCTTGGCTCGAGATAAGCACCATTTGGCTGATCTAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTT
AAAGAGTCTCATGGACGGGATGTACGTGTCATTGTCGTGGGAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATG
CAAAGCAACTGCTCATTAGGTGGTGTGGGGATGATGTGCTCATTGAGTGAACAAGGGAAGCAGCTAGCTATCCAGGTGTCTAATATCCTG
GGGATGGATGTGTGTGGCATTGATCTGCTGATGAAAGATGACGGCTCCTTCTGCGTCTGTGAGGCCAATGCAAATGTAGGTTTCATCGCC
TTTGATAAGGCTTGTAATCTAGATGTAGCTGGTATCATAGCAGACTATGCCGCCTCCCTTCTACCCTCTGGCCGGCTCACCCGGCGTATG
TCCCTGCTCTCCGTGGTGTCCACTGCCAGTGAGACTAGTGAGCCGGAGCTGGGTCCCCCAGCCAGCACTGCTGTTGACAACATGAGTGCA
AGTTCCAGCTCTGTTGACAGCGACCCTGAAAGCACGGAGCGAGAGCTGCTCACCAAGCTCCCAGGGGGCCTGTTCAACATGAACCAGCTG
CTAGCCAATGAAATCAAACTACTGGTGGACTGACTCCACTGGTAATTAACCAACAAAACCCTTGTAAAACTTTCTTTCTTCTTTTCTATT
TTTAAAACCAACTTGCAATGCTGTTCATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGGATTAGTTGGAGAGAGTGGGAGATAGA
TGAGACCTCTGCTAGTAAGATGTTACTTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAGGTGGGGTATAGAAAAATGTCAGGCTC
TCATAGTTACCCTTTTAAATTGCTAAAAAATGTGTATGCTCATAGGCCATGAGGAACAAATACTTTTTTTTTTTCATGGTCCCTTGCTTT
TGTTTTTGTACAAAAAAAAATGGTTTTGCTACAAATATCCAAGTAGCATAACTTCACATTGTGTTGGAAGATTTGTCATCAGTGAGGAAA
ACATCTGCATAAATTACAGGAATTTTTGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTATTAACTAGCAGCTTTAGTTTGTAGTTT
ATGAAATCTTGAGGGGCTCTTTTACTGGGATTTCTTATTTTTTTGTTTTTTCCCGCTTAATTTGGTGGGAGGTCAAATTGAATATAACCC

>57650_57650_2_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000294129_RIMKLB_chr12_8904552_ENST00000535829_length(amino acids)=454AA_BP=203
MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS
LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRR
AAPTTPPPPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGR
DVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACN
LDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIK

--------------------------------------------------------------
>57650_57650_3_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000341520_RIMKLB_chr12_8904552_ENST00000357529_length(transcript)=4854nt_BP=692nt
GGCGGGACAACCGCGGCGCGGCTCGGCGCTCCCGGCCTGGCGTTGTGGCGCCGCAGCCCTTGCCACCTTCCCTGCACCTGCCCTGCCCGG
CCTCATGTACCGCGCGCTGTACGCGTTCCGCTCGGCGGAGCCCAACGCGCTGGCGTTCGCCGCGGGCGAGACCTTCCTGGTGCTAGAGCG
AAGCAGCGCGCACTGGTGGCTGGCCGCGCGGGCGCGCAGTGGTGAGACGGGCTACGTGCCGCCAGCCTACCTGCGCCGCCTGCAGGGCCT
GGAGCAGGATGTCCTCCAGGCCATTGACCGGGCCATCGAGGCTGTACACAACACAGCCATGCGGGATGGTGGCAAGTACAGCCTGGAACA
GCGTGGAGTCCTCCAGAAGCTGATCCACCACCGGAAAGAGACCCTGTCACGCAGAGGCCCTTCAGCCTCCAGTGTTGCAGTTATGACCTC
ATCAACCAGTGACCACCACTTGGATGCTGCTGCAGCCAGGCAGCCCAATGGGGTGTGTCGAGCTGGGTTCGAGCGGCAGCACAGCCTACC
CAGTTCTGAGCATCTTGGGGCAGATGGAGGCCTCTACCAGATCCCACTTCCATCTTCCCAGATCCCACCACAGCCTCGCCGAGCAGCACC
CACCACACCGCCCCCACCAGTGAAGCGCCGAGACCGCGAGGCCCTGATGGCCTCTGGGAGTGGTGGCCACGAAAATTTTGCTAAAATGAT
TGATGAGGCTGAAGTTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCA
CCATTTGGCTGATCTAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACG
TGTCATTGTCGTGGGAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGTGGTGT
GGGGATGATGTGCTCATTGAGTGAACAAGGGAAGCAGCTAGCTATCCAGGTGTCTAATATCCTGGGGATGGATGTGTGTGGCATTGATCT
GCTGATGAAAGATGACGGCTCCTTCTGCGTCTGTGAGGCCAATGCAAATGTAGGTTTCATCGCCTTTGATAAGGCTTGTAATCTAGATGT
AGCTGGTATCATAGCAGACTATGCCGCCTCCCTTCTACCCTCTGGCCGGCTCACCCGGCGTATGTCCCTGCTCTCCGTGGTGTCCACTGC
CAGTGAGACTAGTGAGCCGGAGCTGGGTCCCCCAGCCAGCACTGCTGTTGACAACATGAGTGCAAGTTCCAGCTCTGTTGACAGCGACCC
TGAAAGCACGGAGCGAGAGCTGCTCACCAAGCTCCCAGGGGGCCTGTTCAACATGAACCAGCTGCTAGCCAATGAAATCAAACTACTGGT
GGACTGACTCCACTGGTAATTAACCAACAAAACCCTTGTAAAACTTTCTTTCTTCTTTTCTATTTTTAAAACCAACTTGCAATGCTGTTC
ATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGGATTAGTTGGAGAGAGTGGGAGATAGATGAGACCTCTGCTAGTAAGATGTTAC
TTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAGGTGGGGTATAGAAAAATGTCAGGCTCTCATAGTTACCCTTTTAAATTGCTAA
AAAATGTGTATGCTCATAGGCCATGAGGAACAAATACTTTTTTTTTTTCATGGTCCCTTGCTTTTGTTTTTGTACAAAAAAAAATGGTTT
TGCTACAAATATCCAAGTAGCATAACTTCACATTGTGTTGGAAGATTTGTCATCAGTGAGGAAAACATCTGCATAAATTACAGGAATTTT
TGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTATTAACTAGCAGCTTTAGTTTGTAGTTTATGAAATCTTGAGGGGCTCTTTTACT
GGGATTTCTTATTTTTTTGTTTTTTCCCGCTTAATTTGGTGGGAGGTCAAATTGAATATAACCCAATAAAGGCTTCTTAATGACAAAATT
GGCATGTTTGCATGATGAAATGGAAATGAACAGTATTGCAATGTCCGGTATACAAAATAACATTAATTCAATGTAGATAAAATTACACTA
GTTTAAAATATGTGCATTCACTTGTATTTGTTAGTGTTTTAGTCTTTTTTGAAAGATGTGCTCTGTTAATGTTGCTTTTTTTTTTTTTTT
TAATACATGCTAGTCTAACATTTCCTGCTCTATGCCTGCATCTTTAACAATGGCCAAAGTGAAGAAAATGCTACCTTTTTTGTTAACAAG
ACACTGACTTGAAACATGTACATTTAAAGCCTTTTATTTTTTCCCTTTTTGTTTTGGTAGTTGGGCATTTAAATAAGGACAAGGAAAAAT
ATTTTTGGGGGCAAATCAAGAGCCTATGAGTTCTAAGTATAAAGCTGAAGTGATTTCGAATGCCAGCGTTATATATTTGCATTTTTCACA
TTTTACGAGGGAGTATATGTGTATGTGTGTGCACGCATGCATGTGTATGTGTTTTGCTTTTTGTTTCCATCAACTAATCAAAAAGGATAA
TTTAGAAAATGGAGCATGATGGGAAACAGAGTTTTTGACTTTAAAAAACAGATGAGTTGTTTTCATAAGTAGACTCCACTGGGGTAGAGG
TATTCACCTTAAAACATAGGGTGAGTAGATGCTTTTTTAGGCCTTTTTGTGTATATGTACGTTGTTTGTTTTTTTCCTTTTGTTTCTAGC
CTGTTCAGTGTACAGTTTATTCAAGGCTACATGCTTTTCTTTAATGCTTCTGGCTATGCATTTTCTCTTTTTACATATAGGATTTGGGAT
TGGGGGTGGGTTGGATGTTTTTGTTTGGGGACTTATTTAGTAGTATTGAGTCTCTTATAGCCCTACTCTTAAGCCTTCAATACTGTCCAC
TCTTTATATTCCTTTACTTGCAGAATTTATAAAAGCCCCCAAACTGCATATAATATGAGCCTTTAAAACATGGGTAAAACTAATCCCATT
GATGGGTTTGGATGGTATGTTAAGAAATGGAGATGCTGCAGAGCCCAACGTAATTTTTTAAACAGCAAGTTTTCCATCTCCCTACGAATC
CTCTGAAGCTTTTACCCAAGCCCTTTCTTGCCTCTCCAGTGCTATTTTCCTTCAGATGGACCTTAAACATAATTTCTTGGACACTACTAG
AGAGACTTCGAGGCAATAATAAAAGATCAGTATTAACCAGCTATAACAGAGGTTTGATCATGCTTACTTGTACAGTTTTTCCCCCGTTTT
AAAAAGGAATGTAATAAAATTTGTTTTTTCCATAGAATTAAATAATATTAAAATTGAGTGAAAGGTTGATTGTTGATGAATAGAATAGTA
CCTCTCATCTGTGCAGTGTCTCATTTCACCTCAGAGAAAAGGATACATAAGAGGAGTTTGTAATTTATCTTAGGATATTCTAATTGCATT
TAAAAGAACTTATCTTGCGCAGGGTAAATGGGGGACTCACATACATATATTAATACCTCTGACTCATTAACAGAAAGAAATACTTGGTAC
TTCTTTCGCTGAATGACCATACTGTGGAGGATGCATACTATTTGGTATAGAGAAATAAATGAGGAAGAAAGAACTGCTTAATTAAATTAT
CATTCATATGTTCATATAGAGACCATCTGGTTGCCATGTGTATTATGACACATACACTTTGAATAGTTACATATCACAAGTATGTAGTTC
ATGTTTGTGTTGGTGGGGTAAGGCATCAGGAAAAATGTAGTTAGTCTTTTCTTAACTTATACCAAATTAACCAACTATATTATAGGAAAT
ATGTGAAATTAGTTCATTAGCTTTATTCACTATTATGCATTCACATGATATTAAAACGTACACTCACATGTTAGAATGAAAAGAGCAGTA
GTTATCTTAGATTTTAAAAACATGGATATCTTCTTGAATTCCTTCAAGATTGAGGTAGAGAATAAGAGCAAATCATTCTGGAAGTACCTT
AAGGAAACAAACAGCAGCAGATATTTAGGTTAAACTTATTTTCATAATTGTTTAATAACTTTTGTATAATCTTCATTGCTATTATGAGAG
AGAATGTATATATCAAATATGTGTAATGATAAAATCTGAATTGTAAAATTTTTGTATATTGTTAAAATTGTAATTCTAAATTGTATTTCA
AAAATGATTATTTCTGATATTGTTTTTATGTCACCCATGATGAAAACTGGACTTTATATATCTAAACATACAAGTATGAACTATTCTATT
TAAAATTTTTAATAGTTTTTTTCTTTTTTGGTGCCTATAATTGATTGGTCATTTCTGCTGGCTTTTCTCCAATGAACATTGAAATCTTCC
TGTATATGTTACCAATAAGAAAACTACCCTGGAACAGTAGAAAAACCCAACAAGAGACTTGGCATTCATCAAGCACATTATCAGACTTTG
AGAACATATTGAAGGCATTGACTTTGAAAATCATCTCTTTTTCTCAAGAAGAAAGCAATGGAGAAGCAAATTTGTTTCATTCAGTGAATC
CCCAGTTTGGGGCTTGTGGGGCTTAGAGACATTGTGAAATCAAATCTTGTGTTATACTTTTCTCCTGGCTCACTTTTTTTGAGAAGGTTT
ATGGGCTATTTGGCTGGTGAGACACGATCCCCTCCTAAGAAAATGTAGGTGCTCAGACAGGTAACCACTGCTGCTACTGTTTTTATTTGT

>57650_57650_3_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000341520_RIMKLB_chr12_8904552_ENST00000357529_length(amino acids)=454AA_BP=203
MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS
LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRR
AAPTTPPPPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGR
DVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACN
LDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIK

--------------------------------------------------------------
>57650_57650_4_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000341520_RIMKLB_chr12_8904552_ENST00000535829_length(transcript)=2068nt_BP=692nt
GGCGGGACAACCGCGGCGCGGCTCGGCGCTCCCGGCCTGGCGTTGTGGCGCCGCAGCCCTTGCCACCTTCCCTGCACCTGCCCTGCCCGG
CCTCATGTACCGCGCGCTGTACGCGTTCCGCTCGGCGGAGCCCAACGCGCTGGCGTTCGCCGCGGGCGAGACCTTCCTGGTGCTAGAGCG
AAGCAGCGCGCACTGGTGGCTGGCCGCGCGGGCGCGCAGTGGTGAGACGGGCTACGTGCCGCCAGCCTACCTGCGCCGCCTGCAGGGCCT
GGAGCAGGATGTCCTCCAGGCCATTGACCGGGCCATCGAGGCTGTACACAACACAGCCATGCGGGATGGTGGCAAGTACAGCCTGGAACA
GCGTGGAGTCCTCCAGAAGCTGATCCACCACCGGAAAGAGACCCTGTCACGCAGAGGCCCTTCAGCCTCCAGTGTTGCAGTTATGACCTC
ATCAACCAGTGACCACCACTTGGATGCTGCTGCAGCCAGGCAGCCCAATGGGGTGTGTCGAGCTGGGTTCGAGCGGCAGCACAGCCTACC
CAGTTCTGAGCATCTTGGGGCAGATGGAGGCCTCTACCAGATCCCACTTCCATCTTCCCAGATCCCACCACAGCCTCGCCGAGCAGCACC
CACCACACCGCCCCCACCAGTGAAGCGCCGAGACCGCGAGGCCCTGATGGCCTCTGGGAGTGGTGGCCACGAAAATTTTGCTAAAATGAT
TGATGAGGCTGAAGTTCTGGAGTTCCCAATGGTAGTAAAGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCA
CCATTTGGCTGATCTAAGCCATCTTATTCGCCATGAAGCGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACG
TGTCATTGTCGTGGGAGGCCGTGTGGTTGGCACCATGTTACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGTGGTGT
GGGGATGATGTGCTCATTGAGTGAACAAGGGAAGCAGCTAGCTATCCAGGTGTCTAATATCCTGGGGATGGATGTGTGTGGCATTGATCT
GCTGATGAAAGATGACGGCTCCTTCTGCGTCTGTGAGGCCAATGCAAATGTAGGTTTCATCGCCTTTGATAAGGCTTGTAATCTAGATGT
AGCTGGTATCATAGCAGACTATGCCGCCTCCCTTCTACCCTCTGGCCGGCTCACCCGGCGTATGTCCCTGCTCTCCGTGGTGTCCACTGC
CAGTGAGACTAGTGAGCCGGAGCTGGGTCCCCCAGCCAGCACTGCTGTTGACAACATGAGTGCAAGTTCCAGCTCTGTTGACAGCGACCC
TGAAAGCACGGAGCGAGAGCTGCTCACCAAGCTCCCAGGGGGCCTGTTCAACATGAACCAGCTGCTAGCCAATGAAATCAAACTACTGGT
GGACTGACTCCACTGGTAATTAACCAACAAAACCCTTGTAAAACTTTCTTTCTTCTTTTCTATTTTTAAAACCAACTTGCAATGCTGTTC
ATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGGATTAGTTGGAGAGAGTGGGAGATAGATGAGACCTCTGCTAGTAAGATGTTAC
TTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAGGTGGGGTATAGAAAAATGTCAGGCTCTCATAGTTACCCTTTTAAATTGCTAA
AAAATGTGTATGCTCATAGGCCATGAGGAACAAATACTTTTTTTTTTTCATGGTCCCTTGCTTTTGTTTTTGTACAAAAAAAAATGGTTT
TGCTACAAATATCCAAGTAGCATAACTTCACATTGTGTTGGAAGATTTGTCATCAGTGAGGAAAACATCTGCATAAATTACAGGAATTTT
TGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTATTAACTAGCAGCTTTAGTTTGTAGTTTATGAAATCTTGAGGGGCTCTTTTACT

>57650_57650_4_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000341520_RIMKLB_chr12_8904552_ENST00000535829_length(amino acids)=454AA_BP=203
MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS
LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPLPSSQIPPQPRR
AAPTTPPPPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGR
DVRVIVVGGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACN
LDVAGIIADYAASLLPSGRLTRRMSLLSVVSTASETSEPELGPPASTAVDNMSASSSSVDSDPESTERELLTKLPGGLFNMNQLLANEIK

--------------------------------------------------------------
>57650_57650_5_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000416649_RIMKLB_chr12_8904552_ENST00000357529_length(transcript)=4816nt_BP=654nt
GCGGCTCGGCGCTCCCGGCCTGGCGTTGTGGCGCCGCAGCCCTTGCCACCTTCCCTGCACCTGCCCTGCCCGGCCTCATGTACCGCGCGC
TGTACGCGTTCCGCTCGGCGGAGCCCAACGCGCTGGCGTTCGCCGCGGGCGAGACCTTCCTGGTGCTAGAGCGAAGCAGCGCGCACTGGT
GGCTGGCCGCGCGGGCGCGCAGTGGTGAGACGGGCTACGTGCCGCCAGCCTACCTGCGCCGCCTGCAGGGCCTGGAGCAGGATGTCCTCC
AGGCCATTGACCGGGCCATCGAGGCTGTACACAACACAGCCATGCGGGATGGTGGCAAGTACAGCCTGGAACAGCGTGGAGTCCTCCAGA
AGCTGATCCACCACCGGAAAGAGACCCTGTCACGCAGAGGCCCTTCAGCCTCCAGTGTTGCAGTTATGACCTCATCAACCAGTGACCACC
ACTTGGATGCTGCTGCAGCCAGGCAGCCCAATGGGGTGTGTCGAGCTGGGTTCGAGCGGCAGCACAGCCTACCCAGTTCTGAGCATCTTG
GGGCAGATGGAGGCCTCTACCAGATCCCACCACAGCCTCGCCGAGCAGCACCCACCACACCGCCCCCACCAGTGAAGCGCCGAGACCGCG
AGGCCCTGATGGCCTCTGGGAGTGGTGGCCACGAAAATTTTGCTAAAATGATTGATGAGGCTGAAGTTCTGGAGTTCCCAATGGTAGTAA
AGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCACCATTTGGCTGATCTAAGCCATCTTATTCGCCATGAAG
CGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACGTGTCATTGTCGTGGGAGGCCGTGTGGTTGGCACCATGT
TACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGTGGTGTGGGGATGATGTGCTCATTGAGTGAACAAGGGAAGCAGC
TAGCTATCCAGGTGTCTAATATCCTGGGGATGGATGTGTGTGGCATTGATCTGCTGATGAAAGATGACGGCTCCTTCTGCGTCTGTGAGG
CCAATGCAAATGTAGGTTTCATCGCCTTTGATAAGGCTTGTAATCTAGATGTAGCTGGTATCATAGCAGACTATGCCGCCTCCCTTCTAC
CCTCTGGCCGGCTCACCCGGCGTATGTCCCTGCTCTCCGTGGTGTCCACTGCCAGTGAGACTAGTGAGCCGGAGCTGGGTCCCCCAGCCA
GCACTGCTGTTGACAACATGAGTGCAAGTTCCAGCTCTGTTGACAGCGACCCTGAAAGCACGGAGCGAGAGCTGCTCACCAAGCTCCCAG
GGGGCCTGTTCAACATGAACCAGCTGCTAGCCAATGAAATCAAACTACTGGTGGACTGACTCCACTGGTAATTAACCAACAAAACCCTTG
TAAAACTTTCTTTCTTCTTTTCTATTTTTAAAACCAACTTGCAATGCTGTTCATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGG
ATTAGTTGGAGAGAGTGGGAGATAGATGAGACCTCTGCTAGTAAGATGTTACTTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAG
GTGGGGTATAGAAAAATGTCAGGCTCTCATAGTTACCCTTTTAAATTGCTAAAAAATGTGTATGCTCATAGGCCATGAGGAACAAATACT
TTTTTTTTTTCATGGTCCCTTGCTTTTGTTTTTGTACAAAAAAAAATGGTTTTGCTACAAATATCCAAGTAGCATAACTTCACATTGTGT
TGGAAGATTTGTCATCAGTGAGGAAAACATCTGCATAAATTACAGGAATTTTTGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTAT
TAACTAGCAGCTTTAGTTTGTAGTTTATGAAATCTTGAGGGGCTCTTTTACTGGGATTTCTTATTTTTTTGTTTTTTCCCGCTTAATTTG
GTGGGAGGTCAAATTGAATATAACCCAATAAAGGCTTCTTAATGACAAAATTGGCATGTTTGCATGATGAAATGGAAATGAACAGTATTG
CAATGTCCGGTATACAAAATAACATTAATTCAATGTAGATAAAATTACACTAGTTTAAAATATGTGCATTCACTTGTATTTGTTAGTGTT
TTAGTCTTTTTTGAAAGATGTGCTCTGTTAATGTTGCTTTTTTTTTTTTTTTTAATACATGCTAGTCTAACATTTCCTGCTCTATGCCTG
CATCTTTAACAATGGCCAAAGTGAAGAAAATGCTACCTTTTTTGTTAACAAGACACTGACTTGAAACATGTACATTTAAAGCCTTTTATT
TTTTCCCTTTTTGTTTTGGTAGTTGGGCATTTAAATAAGGACAAGGAAAAATATTTTTGGGGGCAAATCAAGAGCCTATGAGTTCTAAGT
ATAAAGCTGAAGTGATTTCGAATGCCAGCGTTATATATTTGCATTTTTCACATTTTACGAGGGAGTATATGTGTATGTGTGTGCACGCAT
GCATGTGTATGTGTTTTGCTTTTTGTTTCCATCAACTAATCAAAAAGGATAATTTAGAAAATGGAGCATGATGGGAAACAGAGTTTTTGA
CTTTAAAAAACAGATGAGTTGTTTTCATAAGTAGACTCCACTGGGGTAGAGGTATTCACCTTAAAACATAGGGTGAGTAGATGCTTTTTT
AGGCCTTTTTGTGTATATGTACGTTGTTTGTTTTTTTCCTTTTGTTTCTAGCCTGTTCAGTGTACAGTTTATTCAAGGCTACATGCTTTT
CTTTAATGCTTCTGGCTATGCATTTTCTCTTTTTACATATAGGATTTGGGATTGGGGGTGGGTTGGATGTTTTTGTTTGGGGACTTATTT
AGTAGTATTGAGTCTCTTATAGCCCTACTCTTAAGCCTTCAATACTGTCCACTCTTTATATTCCTTTACTTGCAGAATTTATAAAAGCCC
CCAAACTGCATATAATATGAGCCTTTAAAACATGGGTAAAACTAATCCCATTGATGGGTTTGGATGGTATGTTAAGAAATGGAGATGCTG
CAGAGCCCAACGTAATTTTTTAAACAGCAAGTTTTCCATCTCCCTACGAATCCTCTGAAGCTTTTACCCAAGCCCTTTCTTGCCTCTCCA
GTGCTATTTTCCTTCAGATGGACCTTAAACATAATTTCTTGGACACTACTAGAGAGACTTCGAGGCAATAATAAAAGATCAGTATTAACC
AGCTATAACAGAGGTTTGATCATGCTTACTTGTACAGTTTTTCCCCCGTTTTAAAAAGGAATGTAATAAAATTTGTTTTTTCCATAGAAT
TAAATAATATTAAAATTGAGTGAAAGGTTGATTGTTGATGAATAGAATAGTACCTCTCATCTGTGCAGTGTCTCATTTCACCTCAGAGAA
AAGGATACATAAGAGGAGTTTGTAATTTATCTTAGGATATTCTAATTGCATTTAAAAGAACTTATCTTGCGCAGGGTAAATGGGGGACTC
ACATACATATATTAATACCTCTGACTCATTAACAGAAAGAAATACTTGGTACTTCTTTCGCTGAATGACCATACTGTGGAGGATGCATAC
TATTTGGTATAGAGAAATAAATGAGGAAGAAAGAACTGCTTAATTAAATTATCATTCATATGTTCATATAGAGACCATCTGGTTGCCATG
TGTATTATGACACATACACTTTGAATAGTTACATATCACAAGTATGTAGTTCATGTTTGTGTTGGTGGGGTAAGGCATCAGGAAAAATGT
AGTTAGTCTTTTCTTAACTTATACCAAATTAACCAACTATATTATAGGAAATATGTGAAATTAGTTCATTAGCTTTATTCACTATTATGC
ATTCACATGATATTAAAACGTACACTCACATGTTAGAATGAAAAGAGCAGTAGTTATCTTAGATTTTAAAAACATGGATATCTTCTTGAA
TTCCTTCAAGATTGAGGTAGAGAATAAGAGCAAATCATTCTGGAAGTACCTTAAGGAAACAAACAGCAGCAGATATTTAGGTTAAACTTA
TTTTCATAATTGTTTAATAACTTTTGTATAATCTTCATTGCTATTATGAGAGAGAATGTATATATCAAATATGTGTAATGATAAAATCTG
AATTGTAAAATTTTTGTATATTGTTAAAATTGTAATTCTAAATTGTATTTCAAAAATGATTATTTCTGATATTGTTTTTATGTCACCCAT
GATGAAAACTGGACTTTATATATCTAAACATACAAGTATGAACTATTCTATTTAAAATTTTTAATAGTTTTTTTCTTTTTTGGTGCCTAT
AATTGATTGGTCATTTCTGCTGGCTTTTCTCCAATGAACATTGAAATCTTCCTGTATATGTTACCAATAAGAAAACTACCCTGGAACAGT
AGAAAAACCCAACAAGAGACTTGGCATTCATCAAGCACATTATCAGACTTTGAGAACATATTGAAGGCATTGACTTTGAAAATCATCTCT
TTTTCTCAAGAAGAAAGCAATGGAGAAGCAAATTTGTTTCATTCAGTGAATCCCCAGTTTGGGGCTTGTGGGGCTTAGAGACATTGTGAA
ATCAAATCTTGTGTTATACTTTTCTCCTGGCTCACTTTTTTTGAGAAGGTTTATGGGCTATTTGGCTGGTGAGACACGATCCCCTCCTAA
GAAAATGTAGGTGCTCAGACAGGTAACCACTGCTGCTACTGTTTTTATTTGTTTGTTTGTTCAATTTTATTTAAGATTTGTTTTTGTTGT

>57650_57650_5_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000416649_RIMKLB_chr12_8904552_ENST00000357529_length(amino acids)=447AA_BP=196
MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS
LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPRRAAPTTPP
PPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVV
GGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGII

--------------------------------------------------------------
>57650_57650_6_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000416649_RIMKLB_chr12_8904552_ENST00000535829_length(transcript)=2030nt_BP=654nt
GCGGCTCGGCGCTCCCGGCCTGGCGTTGTGGCGCCGCAGCCCTTGCCACCTTCCCTGCACCTGCCCTGCCCGGCCTCATGTACCGCGCGC
TGTACGCGTTCCGCTCGGCGGAGCCCAACGCGCTGGCGTTCGCCGCGGGCGAGACCTTCCTGGTGCTAGAGCGAAGCAGCGCGCACTGGT
GGCTGGCCGCGCGGGCGCGCAGTGGTGAGACGGGCTACGTGCCGCCAGCCTACCTGCGCCGCCTGCAGGGCCTGGAGCAGGATGTCCTCC
AGGCCATTGACCGGGCCATCGAGGCTGTACACAACACAGCCATGCGGGATGGTGGCAAGTACAGCCTGGAACAGCGTGGAGTCCTCCAGA
AGCTGATCCACCACCGGAAAGAGACCCTGTCACGCAGAGGCCCTTCAGCCTCCAGTGTTGCAGTTATGACCTCATCAACCAGTGACCACC
ACTTGGATGCTGCTGCAGCCAGGCAGCCCAATGGGGTGTGTCGAGCTGGGTTCGAGCGGCAGCACAGCCTACCCAGTTCTGAGCATCTTG
GGGCAGATGGAGGCCTCTACCAGATCCCACCACAGCCTCGCCGAGCAGCACCCACCACACCGCCCCCACCAGTGAAGCGCCGAGACCGCG
AGGCCCTGATGGCCTCTGGGAGTGGTGGCCACGAAAATTTTGCTAAAATGATTGATGAGGCTGAAGTTCTGGAGTTCCCAATGGTAGTAA
AGAATACGCGGGGTCACAGAGGTAAAGCTGTTTTCTTGGCTCGAGATAAGCACCATTTGGCTGATCTAAGCCATCTTATTCGCCATGAAG
CGCCATACCTGTTCCAGAAGTATGTTAAAGAGTCTCATGGACGGGATGTACGTGTCATTGTCGTGGGAGGCCGTGTGGTTGGCACCATGT
TACGTTGTTCAACAGATGGGAGAATGCAAAGCAACTGCTCATTAGGTGGTGTGGGGATGATGTGCTCATTGAGTGAACAAGGGAAGCAGC
TAGCTATCCAGGTGTCTAATATCCTGGGGATGGATGTGTGTGGCATTGATCTGCTGATGAAAGATGACGGCTCCTTCTGCGTCTGTGAGG
CCAATGCAAATGTAGGTTTCATCGCCTTTGATAAGGCTTGTAATCTAGATGTAGCTGGTATCATAGCAGACTATGCCGCCTCCCTTCTAC
CCTCTGGCCGGCTCACCCGGCGTATGTCCCTGCTCTCCGTGGTGTCCACTGCCAGTGAGACTAGTGAGCCGGAGCTGGGTCCCCCAGCCA
GCACTGCTGTTGACAACATGAGTGCAAGTTCCAGCTCTGTTGACAGCGACCCTGAAAGCACGGAGCGAGAGCTGCTCACCAAGCTCCCAG
GGGGCCTGTTCAACATGAACCAGCTGCTAGCCAATGAAATCAAACTACTGGTGGACTGACTCCACTGGTAATTAACCAACAAAACCCTTG
TAAAACTTTCTTTCTTCTTTTCTATTTTTAAAACCAACTTGCAATGCTGTTCATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGG
ATTAGTTGGAGAGAGTGGGAGATAGATGAGACCTCTGCTAGTAAGATGTTACTTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAG
GTGGGGTATAGAAAAATGTCAGGCTCTCATAGTTACCCTTTTAAATTGCTAAAAAATGTGTATGCTCATAGGCCATGAGGAACAAATACT
TTTTTTTTTTCATGGTCCCTTGCTTTTGTTTTTGTACAAAAAAAAATGGTTTTGCTACAAATATCCAAGTAGCATAACTTCACATTGTGT
TGGAAGATTTGTCATCAGTGAGGAAAACATCTGCATAAATTACAGGAATTTTTGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTAT
TAACTAGCAGCTTTAGTTTGTAGTTTATGAAATCTTGAGGGGCTCTTTTACTGGGATTTCTTATTTTTTTGTTTTTTCCCGCTTAATTTG

>57650_57650_6_NCKIPSD-RIMKLB_NCKIPSD_chr3_48719477_ENST00000416649_RIMKLB_chr12_8904552_ENST00000535829_length(amino acids)=447AA_BP=196
MPGLMYRALYAFRSAEPNALAFAAGETFLVLERSSAHWWLAARARSGETGYVPPAYLRRLQGLEQDVLQAIDRAIEAVHNTAMRDGGKYS
LEQRGVLQKLIHHRKETLSRRGPSASSVAVMTSSTSDHHLDAAAARQPNGVCRAGFERQHSLPSSEHLGADGGLYQIPPQPRRAAPTTPP
PPVKRRDREALMASGSGGHENFAKMIDEAEVLEFPMVVKNTRGHRGKAVFLARDKHHLADLSHLIRHEAPYLFQKYVKESHGRDVRVIVV
GGRVVGTMLRCSTDGRMQSNCSLGGVGMMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGII

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Fusion Gene PPI Analysis for NCKIPSD-RIMKLB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCKIPSD-RIMKLB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCKIPSD-RIMKLB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource