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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NCOA3-ACTR5 (FusionGDB2 ID:57729)

Fusion Gene Summary for NCOA3-ACTR5

Fusion gene summary

Fusion gene information	Fusion gene name: NCOA3-ACTR5
	Fusion gene ID: 57729
		Hgene	Tgene
	Gene symbol	NCOA3	ACTR5
	Gene ID	8202	79913
	Gene name	nuclear receptor coactivator 3	actin related protein 5
	Synonyms	ACTR\|AIB-1\|AIB1\|CAGH16\|CTG26\|KAT13B\|RAC3\|SRC-3\|SRC3\|TNRC14\|TNRC16\|TRAM-1\|bHLHe42\|pCIP	Arp5\|INO80M
	Cytomap	20q13.12	20q11.23
	Type of gene	protein-coding	protein-coding
	Description	nuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1	actin-related protein 5ARP5 actin related protein 5 homologINO80 complex subunit MhARP5sarcoma antigen NY-SAR-16
	Modification date	20200313	20200313
	UniProtAcc	Q9Y6Q9	Q9H9F9
	Ensembl transtripts involved in fusion gene	ENST00000497292, ENST00000341724, ENST00000371997, ENST00000371998, ENST00000372004,	ENST00000243903,
Fusion gene scores	* DoF score	27 X 14 X 11=4158	4 X 3 X 3=36
	# samples	35	4
	** MAII score	log2(35/4158*10)=-3.57046293102604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: NCOA3 [Title/Abstract] AND ACTR5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NCOA3(46256767)-ACTR5(37383599), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NCOA3	GO:0045944	positive regulation of transcription by RNA polymerase II	9267036
Hgene	NCOA3	GO:0071392	cellular response to estradiol stimulus	15831516

Fusion gene breakpoints across NCOA3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACTR5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-GI-A2C9	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+

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Fusion Gene ORF analysis for NCOA3-ACTR5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000497292	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+
In-frame	ENST00000341724	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+
In-frame	ENST00000371997	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+
In-frame	ENST00000371998	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+
In-frame	ENST00000372004	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000341724

NCOA3

chr20

46256767

ENST00000243903

ACTR5

chr20

37383599

2508

1084

261

2132

623

ENST00000372004

NCOA3

chr20

46256767

ENST00000243903

ACTR5

chr20

37383599

2463

1039

216

2087

623

ENST00000371998

NCOA3

chr20

46256767

ENST00000243903

ACTR5

chr20

37383599

2438

1014

191

2062

623

ENST00000371997

NCOA3

chr20

46256767

ENST00000243903

ACTR5

chr20

37383599

2424

1000

177

2048

623

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000341724	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+	0.001942947	0.99805707
ENST00000372004	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+	0.001989263	0.9980108
ENST00000371998	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+	0.001869686	0.9981304
ENST00000371997	ENST00000243903	NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+	0.001896684	0.99810326

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Fusion Genomic Features for NCOA3-ACTR5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+	3.54E-06	0.9999964
NCOA3	chr20	46256767	+	ACTR5	chr20	37383599	+	3.54E-06	0.9999964

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCOA3-ACTR5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:46256767/chr20:37383599)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NCOA3 Q9Y6Q9	ACTR5 Q9H9F9
FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.	FUNCTION: Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. {ECO:0000269\|PubMed:19014934, ECO:0000269\|PubMed:20855601}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

110_180

274

1416.0

Domain

PAS

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

25_82

274

1416.0

Domain

bHLH

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

110_180

274

1425.0

Domain

PAS

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

25_82

274

1425.0

Domain

bHLH

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

110_180

274

1421.0

Domain

PAS

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

25_82

274

1421.0

Domain

bHLH

Tgene

ACTR5

chr20:46256767

chr20:37383599

ENST00000243903

288_327

258

608.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ACTR5

chr20:46256767

chr20:37383599

ENST00000243903

355_384

258

608.0

Coiled coil

Ontology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

1248_1278

274

1416.0

Compositional bias

Note=Poly-Gln

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

1392_1417

274

1416.0

Compositional bias

Note=Met-rich

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

505_671

274

1416.0

Compositional bias

Note=Ser-rich

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

976_980

274

1416.0

Compositional bias

Note=Poly-Gln

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

1248_1278

274

1425.0

Compositional bias

Note=Poly-Gln

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

1392_1417

274

1425.0

Compositional bias

Note=Met-rich

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

505_671

274

1425.0

Compositional bias

Note=Ser-rich

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

976_980

274

1425.0

Compositional bias

Note=Poly-Gln

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

1248_1278

274

1421.0

Compositional bias

Note=Poly-Gln

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

1392_1417

274

1421.0

Compositional bias

Note=Met-rich

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

505_671

274

1421.0

Compositional bias

Note=Ser-rich

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

976_980

274

1421.0

Compositional bias

Note=Poly-Gln

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

1057_1061

274

1416.0

Motif

Note=LXXLL motif 3

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

685_689

274

1416.0

Motif

Note=LXXLL motif 1

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

738_742

274

1416.0

Motif

Note=LXXLL motif 2

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

1057_1061

274

1425.0

Motif

Note=LXXLL motif 3

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

685_689

274

1425.0

Motif

Note=LXXLL motif 1

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

738_742

274

1425.0

Motif

Note=LXXLL motif 2

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

1057_1061

274

1421.0

Motif

Note=LXXLL motif 3

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

685_689

274

1421.0

Motif

Note=LXXLL motif 1

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

738_742

274

1421.0

Motif

Note=LXXLL motif 2

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371997

1097_1304

274

1416.0

Region

Note=Acetyltransferase

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000371998

1097_1304

274

1425.0

Region

Note=Acetyltransferase

Hgene

NCOA3

chr20:46256767

chr20:37383599

ENST00000372004

1097_1304

274

1421.0

Region

Note=Acetyltransferase

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Fusion Gene Sequence for NCOA3-ACTR5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>57729_57729_1_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000341724_ACTR5_chr20_37383599_ENST00000243903_length(transcript)=2508nt_BP=1084nt
ATATCCCAGTGGCCCCCGTGCGGCGACTTTAGCTGCTGCTGTCTCAGCCGCTCCACAGCGACGGCAGCGGCTGCGGCTTAGTCGGTGGCG
GCCGGCGGCGGCTGCGGGCTGAGCGGCGAGTTTCCGATTTAAAGCTGAGCTGCGAGGAAAATGGCGGCGGGAGGATCAAAATACTTGCTG
GATGGTGGACTCAGAGACCAATAAAAATAAACTGCTTGAACATCCTTTGACTGGTTAGCCAGTTGCTGATGTATATTCAAGATGAGTGGA
TTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGCAAATTGCCATGTGATACTCCAGGACAAGGTCTTACCTGCAGTGGT
GAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTGGCTGAGCTGATATCTGCCAATCTTAGTGATATTGACAATTTCAAT
GTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAGATACGTCAAATAAAAGAGCAAGGAAAAACTATTTCCAATGATGAT
GATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATTGATAAAGACTCCTTAGGACCGCTTTTACTTCAGGCATTGGATGGT
TTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCAGAAAATGTCACACAATACCTGCAATATAAGCAAGAGGACCTGGTT
AACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGATTTTCTTAAGAATTTACCAAAATCTACAGTTAATGGAGTTTCCTGG
ACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGTATGTTGATGAAAACACCACATGATATTCTGGAAGACATAAACGCC
AGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCCCTGTCTCAGCCACGAGCTATGATGGAGGAAGGGGAAGATTTGCAA
TCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGAACATTTCCATCAAACCCTGAGAGCTTTATTACCAGACATGATCTT
TCAGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGC
ACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTG
CAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAACTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCTCTGATA
GAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAGAAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATCCTCCAA
GCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAGACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGATGTGGAA
AGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGAGTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAACTTGGCA
GCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCAGAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAGGCTGGG
ATTGCAGAGACTCTTCAGTACATTCTGGACAGGTACCCAAAGGACATTCAGGAAATGCTGGTTCAGAACGTTTTCCTCACTGGCGGCAAC
ACGATGTATCCTGGCATGAAAGCCAGAATGGAGAAGGAACTGTTGGAGATGAGACCCTTCCGGTCTTCTTTTCAGGTTCAACTTGCCTCG
AACCCTGTGCTGGATGCCTGGTACGGTGCTCGTGACTGGGCCTTGAACCACCTAGATGATAATGAAGTTTGGATCACCAGGAAAGAGTAT
GAAGAAAAGGGAGGAGAGTACCTCAAGGAGCACTGTGCTTCCAACATCTATGTCCCCATCCGCCTGCCGAAGCAGGCCTCCCGCTCCTCA
GATGCCCAGGCATCCAGCAAGGGCTCCGCTGCTGGTGGAGGTGGTGCTGGTGAGCAGGCATAGCAGAGGCCCTCCAGAGAGACTGCCCTG
CACGCCATGCCTTGGGCCACGTTGGCAGTGTGACAGGACTGTGATTGTGCTAGATGTACCTGCCCAAGTCTGCTGGTCACATTTGGCAGC
AAAATGGATTTCTCCTGGGGAGAACAAAGTTAAGGGACACTGAGACCTGCCCTTCAGAATTCGGTTCACTTGGGGGCTTCTGTGGTAGAG
ACTAACTGGCCTTCTGATGTCTTTGTTCAACTGTGGCCAGCTGTGGCATCAGCTTCCTGGAGCAGTAAATGAAGACAGAGTGGAGGACAC

>57729_57729_1_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000341724_ACTR5_chr20_37383599_ENST00000243903_length(amino acids)=623AA_BP=274
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS
NDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITR
HDLSELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHK
ALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVF
NLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQ

--------------------------------------------------------------
>57729_57729_2_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000371997_ACTR5_chr20_37383599_ENST00000243903_length(transcript)=2424nt_BP=1000nt
GTGGCGGCCGGCGGCGGCTGCGGGCTGAGCGGCGAGTTTCCGATTTAAAGCTGAGCTGCGAGGAAAATGGCGGCGGGAGGATCAAAATAC
TTGCTGGATGGTGGACTCAGAGACCAATAAAAATAAACTGCTTGAACATCCTTTGACTGGTTAGCCAGTTGCTGATGTATATTCAAGATG
AGTGGATTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGCAAATTGCCATGTGATACTCCAGGACAAGGTCTTACCTGC
AGTGGTGAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTGGCTGAGCTGATATCTGCCAATCTTAGTGATATTGACAAT
TTCAATGTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAGATACGTCAAATAAAAGAGCAAGGAAAAACTATTTCCAAT
GATGATGATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATTGATAAAGACTCCTTAGGACCGCTTTTACTTCAGGCATTG
GATGGTTTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCAGAAAATGTCACACAATACCTGCAATATAAGCAAGAGGAC
CTGGTTAACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGATTTTCTTAAGAATTTACCAAAATCTACAGTTAATGGAGTT
TCCTGGACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGTATGTTGATGAAAACACCACATGATATTCTGGAAGACATA
AACGCCAGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCCCTGTCTCAGCCACGAGCTATGATGGAGGAAGGGGAAGAT
TTGCAATCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGAACATTTCCATCAAACCCTGAGAGCTTTATTACCAGACAT
GATCTTTCAGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTG
GGCAGCACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAG
AAGCTGCAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAACTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCT
CTGATAGAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAGAAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATC
CTCCAAGCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAGACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGAT
GTGGAAAGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGAGTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAAC
TTGGCAGCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCAGAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAG
GCTGGGATTGCAGAGACTCTTCAGTACATTCTGGACAGGTACCCAAAGGACATTCAGGAAATGCTGGTTCAGAACGTTTTCCTCACTGGC
GGCAACACGATGTATCCTGGCATGAAAGCCAGAATGGAGAAGGAACTGTTGGAGATGAGACCCTTCCGGTCTTCTTTTCAGGTTCAACTT
GCCTCGAACCCTGTGCTGGATGCCTGGTACGGTGCTCGTGACTGGGCCTTGAACCACCTAGATGATAATGAAGTTTGGATCACCAGGAAA
GAGTATGAAGAAAAGGGAGGAGAGTACCTCAAGGAGCACTGTGCTTCCAACATCTATGTCCCCATCCGCCTGCCGAAGCAGGCCTCCCGC
TCCTCAGATGCCCAGGCATCCAGCAAGGGCTCCGCTGCTGGTGGAGGTGGTGCTGGTGAGCAGGCATAGCAGAGGCCCTCCAGAGAGACT
GCCCTGCACGCCATGCCTTGGGCCACGTTGGCAGTGTGACAGGACTGTGATTGTGCTAGATGTACCTGCCCAAGTCTGCTGGTCACATTT
GGCAGCAAAATGGATTTCTCCTGGGGAGAACAAAGTTAAGGGACACTGAGACCTGCCCTTCAGAATTCGGTTCACTTGGGGGCTTCTGTG
GTAGAGACTAACTGGCCTTCTGATGTCTTTGTTCAACTGTGGCCAGCTGTGGCATCAGCTTCCTGGAGCAGTAAATGAAGACAGAGTGGA

>57729_57729_2_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000371997_ACTR5_chr20_37383599_ENST00000243903_length(amino acids)=623AA_BP=274
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS
NDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITR
HDLSELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHK
ALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVF
NLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQ

--------------------------------------------------------------
>57729_57729_3_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000371998_ACTR5_chr20_37383599_ENST00000243903_length(transcript)=2438nt_BP=1014nt
CTGCGGCTTAGTCGGTGGCGGCCGGCGGCGGCTGCGGGCTGAGCGGCGAGTTTCCGATTTAAAGCTGAGCTGCGAGGAAAATGGCGGCGG
GAGGATCAAAATACTTGCTGGATGGTGGACTCAGAGACCAATAAAAATAAACTGCTTGAACATCCTTTGACTGGTTAGCCAGTTGCTGAT
GTATATTCAAGATGAGTGGATTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGCAAATTGCCATGTGATACTCCAGGAC
AAGGTCTTACCTGCAGTGGTGAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTGGCTGAGCTGATATCTGCCAATCTTA
GTGATATTGACAATTTCAATGTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAGATACGTCAAATAAAAGAGCAAGGAA
AAACTATTTCCAATGATGATGATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATTGATAAAGACTCCTTAGGACCGCTTT
TACTTCAGGCATTGGATGGTTTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCAGAAAATGTCACACAATACCTGCAAT
ATAAGCAAGAGGACCTGGTTAACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGATTTTCTTAAGAATTTACCAAAATCTA
CAGTTAATGGAGTTTCCTGGACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGTATGTTGATGAAAACACCACATGATA
TTCTGGAAGACATAAACGCCAGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCCCTGTCTCAGCCACGAGCTATGATGG
AGGAAGGGGAAGATTTGCAATCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGAACATTTCCATCAAACCCTGAGAGCT
TTATTACCAGACATGATCTTTCAGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAATGTCCACAAGATGCAGCTCCCATTTT
CCAGCAAGCTCCTGGGCAGCACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTGCGGCGGCTGCAGGAGCTCAATGCCC
GGCGGCGGGAGGAGAAGCTGCAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAACTTCTAGAGGATGGCCAGATGGATC
AGTTTCACAAAGCTCTGATAGAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAGAAGCTCAGTATAGCAGTGGAGCAGG
CTAAGCAGAAAATCCTCCAAGCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAGACCCCTGACCTGGAGCAGCTGGAGC
CGTCTTTGGAAGATGTGGAAAGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGAGTGGAGAAGCCGGTCACCACTGTTC
AGCCCGTGTTTAACTTGGCAGCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCAGAGATTATTTTCCAGCCATCTCTCA
TAGGAGAAGAACAGGCTGGGATTGCAGAGACTCTTCAGTACATTCTGGACAGGTACCCAAAGGACATTCAGGAAATGCTGGTTCAGAACG
TTTTCCTCACTGGCGGCAACACGATGTATCCTGGCATGAAAGCCAGAATGGAGAAGGAACTGTTGGAGATGAGACCCTTCCGGTCTTCTT
TTCAGGTTCAACTTGCCTCGAACCCTGTGCTGGATGCCTGGTACGGTGCTCGTGACTGGGCCTTGAACCACCTAGATGATAATGAAGTTT
GGATCACCAGGAAAGAGTATGAAGAAAAGGGAGGAGAGTACCTCAAGGAGCACTGTGCTTCCAACATCTATGTCCCCATCCGCCTGCCGA
AGCAGGCCTCCCGCTCCTCAGATGCCCAGGCATCCAGCAAGGGCTCCGCTGCTGGTGGAGGTGGTGCTGGTGAGCAGGCATAGCAGAGGC
CCTCCAGAGAGACTGCCCTGCACGCCATGCCTTGGGCCACGTTGGCAGTGTGACAGGACTGTGATTGTGCTAGATGTACCTGCCCAAGTC
TGCTGGTCACATTTGGCAGCAAAATGGATTTCTCCTGGGGAGAACAAAGTTAAGGGACACTGAGACCTGCCCTTCAGAATTCGGTTCACT
TGGGGGCTTCTGTGGTAGAGACTAACTGGCCTTCTGATGTCTTTGTTCAACTGTGGCCAGCTGTGGCATCAGCTTCCTGGAGCAGTAAAT
GAAGACAGAGTGGAGGACACAAATGTACAAAATGCACAAGACTGATTTCTTACCACATTTTAGTCTTTCTTGTTTTAAAAAAAATTCTTT

>57729_57729_3_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000371998_ACTR5_chr20_37383599_ENST00000243903_length(amino acids)=623AA_BP=274
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS
NDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITR
HDLSELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHK
ALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVF
NLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQ

--------------------------------------------------------------
>57729_57729_4_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000372004_ACTR5_chr20_37383599_ENST00000243903_length(transcript)=2463nt_BP=1039nt
AGCCGCTCCACAGCGACGGCAGCGGCTGCGGCTTAGTCGGTGGCGGCCGGCGGCGGCTGCGGGCTGAGCGGCGAGTTTCCGATTTAAAGC
TGAGCTGCGAGGAAAATGGCGGCGGGAGGATCAAAATACTTGCTGGATGGTGGACTCAGAGACCAATAAAAATAAACTGCTTGAACATCC
TTTGACTGGTTAGCCAGTTGCTGATGTATATTCAAGATGAGTGGATTAGGAGAAAACTTGGATCCACTGGCCAGTGATTCACGAAAACGC
AAATTGCCATGTGATACTCCAGGACAAGGTCTTACCTGCAGTGGTGAAAAACGGAGACGGGAGCAGGAAAGTAAATATATTGAAGAATTG
GCTGAGCTGATATCTGCCAATCTTAGTGATATTGACAATTTCAATGTCAAACCAGATAAATGTGCGATTTTAAAGGAAACAGTAAGACAG
ATACGTCAAATAAAAGAGCAAGGAAAAACTATTTCCAATGATGATGATGTTCAAAAAGCCGATGTATCTTCTACAGGGCAGGGAGTTATT
GATAAAGACTCCTTAGGACCGCTTTTACTTCAGGCATTGGATGGTTTCCTATTTGTGGTGAATCGAGACGGAAACATTGTATTTGTATCA
GAAAATGTCACACAATACCTGCAATATAAGCAAGAGGACCTGGTTAACACAAGTGTTTACAATATCTTACATGAAGAAGACAGAAAGGAT
TTTCTTAAGAATTTACCAAAATCTACAGTTAATGGAGTTTCCTGGACAAATGAGACCCAAAGACAAAAAAGCCATACATTTAATTGCCGT
ATGTTGATGAAAACACCACATGATATTCTGGAAGACATAAACGCCAGTCCTGAAATGCGCCAGAGATATGAAACAATGCAGTGCTTTGCC
CTGTCTCAGCCACGAGCTATGATGGAGGAAGGGGAAGATTTGCAATCTTGTATGATCTGTGTGGCACGCCGCATTACTACAGGAGAAAGA
ACATTTCCATCAAACCCTGAGAGCTTTATTACCAGACATGATCTTTCAGAATTACACAAATGGCGGTGTCCTGATTATTATGAGAATAAT
GTCCACAAGATGCAGCTCCCATTTTCCAGCAAGCTCCTGGGCAGCACTCTGACCTCTGAGGAGAAACAAGAAAGGCGGCAGCAGCAATTG
CGGCGGCTGCAGGAGCTCAATGCCCGGCGGCGGGAGGAGAAGCTGCAGCTGGATCAGGAGCGTCTGGACCGACTGCTATATGTGCAGGAA
CTTCTAGAGGATGGCCAGATGGATCAGTTTCACAAAGCTCTGATAGAGCTGAATATGGACTCCCCAGAAGAGCTGCAGTCCTACATCCAG
AAGCTCAGTATAGCAGTGGAGCAGGCTAAGCAGAAAATCCTCCAAGCGGAAGTCAACCTCGAGGTGGATGTGGTAGACAGCAAGCCAGAG
ACCCCTGACCTGGAGCAGCTGGAGCCGTCTTTGGAAGATGTGGAAAGCATGAATGATTTTGATCCCTTGTTTTCAGAGGAAACACCTGGA
GTGGAGAAGCCGGTCACCACTGTTCAGCCCGTGTTTAACTTGGCAGCATATCATCAGCTATTTGTTGGGACAGAAAGAATTCGAGCTCCA
GAGATTATTTTCCAGCCATCTCTCATAGGAGAAGAACAGGCTGGGATTGCAGAGACTCTTCAGTACATTCTGGACAGGTACCCAAAGGAC
ATTCAGGAAATGCTGGTTCAGAACGTTTTCCTCACTGGCGGCAACACGATGTATCCTGGCATGAAAGCCAGAATGGAGAAGGAACTGTTG
GAGATGAGACCCTTCCGGTCTTCTTTTCAGGTTCAACTTGCCTCGAACCCTGTGCTGGATGCCTGGTACGGTGCTCGTGACTGGGCCTTG
AACCACCTAGATGATAATGAAGTTTGGATCACCAGGAAAGAGTATGAAGAAAAGGGAGGAGAGTACCTCAAGGAGCACTGTGCTTCCAAC
ATCTATGTCCCCATCCGCCTGCCGAAGCAGGCCTCCCGCTCCTCAGATGCCCAGGCATCCAGCAAGGGCTCCGCTGCTGGTGGAGGTGGT
GCTGGTGAGCAGGCATAGCAGAGGCCCTCCAGAGAGACTGCCCTGCACGCCATGCCTTGGGCCACGTTGGCAGTGTGACAGGACTGTGAT
TGTGCTAGATGTACCTGCCCAAGTCTGCTGGTCACATTTGGCAGCAAAATGGATTTCTCCTGGGGAGAACAAAGTTAAGGGACACTGAGA
CCTGCCCTTCAGAATTCGGTTCACTTGGGGGCTTCTGTGGTAGAGACTAACTGGCCTTCTGATGTCTTTGTTCAACTGTGGCCAGCTGTG
GCATCAGCTTCCTGGAGCAGTAAATGAAGACAGAGTGGAGGACACAAATGTACAAAATGCACAAGACTGATTTCTTACCACATTTTAGTC

>57729_57729_4_NCOA3-ACTR5_NCOA3_chr20_46256767_ENST00000372004_ACTR5_chr20_37383599_ENST00000243903_length(amino acids)=623AA_BP=274
MSGLGENLDPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDIDNFNVKPDKCAILKETVRQIRQIKEQGKTIS
NDDDVQKADVSSTGQGVIDKDSLGPLLLQALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNLPKSTVNG
VSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMMEEGEDLQSCMICVARRITTGERTFPSNPESFITR
HDLSELHKWRCPDYYENNVHKMQLPFSSKLLGSTLTSEEKQERRQQQLRRLQELNARRREEKLQLDQERLDRLLYVQELLEDGQMDQFHK
ALIELNMDSPEELQSYIQKLSIAVEQAKQKILQAEVNLEVDVVDSKPETPDLEQLEPSLEDVESMNDFDPLFSEETPGVEKPVTTVQPVF
NLAAYHQLFVGTERIRAPEIIFQPSLIGEEQAGIAETLQYILDRYPKDIQEMLVQNVFLTGGNTMYPGMKARMEKELLEMRPFRSSFQVQ

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NCOA3-ACTR5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	NCOA3	chr20:46256767	chr20:37383599	ENST00000371997	+	8	23	1023_1093	274.3333333333333	1416.0	CREBBP
Hgene	NCOA3	chr20:46256767	chr20:37383599	ENST00000371998	+	8	23	1023_1093	274.3333333333333	1425.0	CREBBP
Hgene	NCOA3	chr20:46256767	chr20:37383599	ENST00000372004	+	8	23	1023_1093	274.3333333333333	1421.0	CREBBP

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NCOA3-ACTR5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NCOA3-ACTR5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source