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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOA5-CDH4 (FusionGDB2 ID:57779)

Fusion Gene Summary for NCOA5-CDH4

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA5-CDH4
Fusion gene ID: 57779
HgeneTgene
Gene symbol

NCOA5

CDH4

Gene ID

57727

1002

Gene namenuclear receptor coactivator 5cadherin 4
SynonymsCIA|bA465L10.6CAD4|R-CAD|RCAD
Cytomap

20q13.12

20q13.33

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 5NCoA-5coactivator independent of AF-2cadherin-4R-cadherincadherin 4, type 1, R-cadherin (retinal)cadherin 4, type 1, preproproteinretinal cadherin
Modification date2020031320200313
UniProtAcc

Q9HCD5

P55283

Ensembl transtripts involved in fusion geneENST00000290231, ENST00000543233, 
ENST00000360469, 
Fusion gene scores* DoF score9 X 11 X 4=39616 X 14 X 7=1568
# samples 1021
** MAII scorelog2(10/396*10)=-1.98550043030488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1568*10)=-2.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOA5 [Title/Abstract] AND CDH4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOA5(44708026)-CDH4(60318619), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NCOA5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDH4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A091-01ANCOA5chr20

44708026

-CDH4chr20

60318619

+
ChimerDB4BRCATCGA-A8-A091-01ANCOA5chr20

44718456

-CDH4chr20

60318619

+
ChimerDB4BRCATCGA-A8-A091NCOA5chr20

44708025

-CDH4chr20

60318618

+
ChimerDB4BRCATCGA-A8-A091NCOA5chr20

44718455

-CDH4chr20

60318618

+


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Fusion Gene ORF analysis for NCOA5-CDH4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000290231ENST00000543233NCOA5chr20

44708026

-CDH4chr20

60318619

+
5CDS-5UTRENST00000290231ENST00000543233NCOA5chr20

44708025

-CDH4chr20

60318618

+
5UTR-3CDSENST00000290231ENST00000360469NCOA5chr20

44718456

-CDH4chr20

60318619

+
5UTR-3CDSENST00000290231ENST00000360469NCOA5chr20

44718455

-CDH4chr20

60318618

+
5UTR-5UTRENST00000290231ENST00000543233NCOA5chr20

44718456

-CDH4chr20

60318619

+
5UTR-5UTRENST00000290231ENST00000543233NCOA5chr20

44718455

-CDH4chr20

60318618

+
In-frameENST00000290231ENST00000360469NCOA5chr20

44708026

-CDH4chr20

60318619

+
In-frameENST00000290231ENST00000360469NCOA5chr20

44708025

-CDH4chr20

60318618

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290231NCOA5chr2044708026-ENST00000360469CDH4chr2060318619+64572032562784842
ENST00000290231NCOA5chr2044708025-ENST00000360469CDH4chr2060318618+64572032562784842

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290231ENST00000360469NCOA5chr2044708026-CDH4chr2060318619+0.003769360.99623066
ENST00000290231ENST00000360469NCOA5chr2044708025-CDH4chr2060318618+0.003769360.99623066

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Fusion Genomic Features for NCOA5-CDH4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOA5chr2044708025-CDH4chr2060318618+0.0054158540.99458414
NCOA5chr2044708025-CDH4chr2060318618+0.0054158540.99458414
NCOA5chr2044718455-CDH4chr2060318618+1.69E-050.9999831
NCOA5chr2044718455-CDH4chr2060318618+1.69E-050.9999831
NCOA5chr2044708025-CDH4chr2060318618+0.0054158540.99458414
NCOA5chr2044708025-CDH4chr2060318618+0.0054158540.99458414
NCOA5chr2044718455-CDH4chr2060318618+1.69E-050.9999831
NCOA5chr2044718455-CDH4chr2060318618+1.69E-050.9999831

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCOA5-CDH4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:44708026/chr20:60318619)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA5

Q9HCD5

CDH4

P55283

FUNCTION: Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2). {ECO:0000269|PubMed:15073177}.FUNCTION: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116873_88856917.0Compositional biasNote=Ser-rich
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015873_8880843.0Compositional biasNote=Ser-rich
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116873_88856917.0Compositional biasNote=Ser-rich
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015873_8880843.0Compositional biasNote=Ser-rich
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116170_27756917.0DomainCadherin 1
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116278_39256917.0DomainCadherin 2
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116393_50756917.0DomainCadherin 3
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116508_61356917.0DomainCadherin 4
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116614_72456917.0DomainCadherin 5
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015170_2770843.0DomainCadherin 1
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015278_3920843.0DomainCadherin 2
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015393_5070843.0DomainCadherin 3
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015508_6130843.0DomainCadherin 4
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015614_7240843.0DomainCadherin 5
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116170_27756917.0DomainCadherin 1
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116278_39256917.0DomainCadherin 2
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116393_50756917.0DomainCadherin 3
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116508_61356917.0DomainCadherin 4
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116614_72456917.0DomainCadherin 5
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015170_2770843.0DomainCadherin 1
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015278_3920843.0DomainCadherin 2
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015393_5070843.0DomainCadherin 3
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015508_6130843.0DomainCadherin 4
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015614_7240843.0DomainCadherin 5
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116170_73456917.0Topological domainExtracellular
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116757_91656917.0Topological domainCytoplasmic
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015170_7340843.0Topological domainExtracellular
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015757_9160843.0Topological domainCytoplasmic
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116170_73456917.0Topological domainExtracellular
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116757_91656917.0Topological domainCytoplasmic
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015170_7340843.0Topological domainExtracellular
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015757_9160843.0Topological domainCytoplasmic
TgeneCDH4chr20:44708025chr20:60318618ENST00000360469116735_75656917.0TransmembraneHelical
TgeneCDH4chr20:44708025chr20:60318618ENST00000543233015735_7560843.0TransmembraneHelical
TgeneCDH4chr20:44708026chr20:60318619ENST00000360469116735_75656917.0TransmembraneHelical
TgeneCDH4chr20:44708026chr20:60318619ENST00000543233015735_7560843.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOA5chr20:44708025chr20:60318618ENST00000290231-287_15012580.0Compositional biasNote=Arg/Asp-rich (mixed charge)
HgeneNCOA5chr20:44708026chr20:60318619ENST00000290231-287_15012580.0Compositional biasNote=Arg/Asp-rich (mixed charge)
HgeneNCOA5chr20:44708025chr20:60318618ENST00000290231-28345_34912580.0MotifNote=LXXLL motif
HgeneNCOA5chr20:44708026chr20:60318619ENST00000290231-28345_34912580.0MotifNote=LXXLL motif
HgeneNCOA5chr20:44708025chr20:60318618ENST00000290231-281_15812580.0RegionNote=Transcription repression
HgeneNCOA5chr20:44708025chr20:60318618ENST00000290231-28458_57912580.0RegionNote=Transcription activation
HgeneNCOA5chr20:44708026chr20:60318619ENST00000290231-281_15812580.0RegionNote=Transcription repression
HgeneNCOA5chr20:44708026chr20:60318619ENST00000290231-28458_57912580.0RegionNote=Transcription activation


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Fusion Gene Sequence for NCOA5-CDH4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57779_57779_1_NCOA5-CDH4_NCOA5_chr20_44708025_ENST00000290231_CDH4_chr20_60318618_ENST00000360469_length(transcript)=6457nt_BP=203nt
CGGCCGCCATTGCCTCGTGCCCGCGCCGGTCGGTTGGTGGCGCCTTTGTCCTACGGCGGGCAGGTGGGCCGACGCGGAGGCGGCAGCGGC
GGGCCTGAGGCGAAGGAGCGGCCGGGAGCCCGCCGCGCTGGTAGCGATATTAATAAGGCAGCGGAAAGAAGAAATATGAATACGGCTCCA
TCAAGACCCAGCCCCACACGAAGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAGCATGGACTTCAAAGT
TGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGCATGGGACAGCCAGAC
AGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCAGAAAGGAAAGAAGGT
CGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCTGAGGCGGCGCAAACG
GGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCGGTCCGACAAAGACAA
TGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTCCATGTCCGGCCGGAT
GTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGGCAACAAGGTGGAGAA
CCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGGCTCCGTGGACGAGGG
CTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGTGCGGTACCGGATCGT
GACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGCGGCTGGCCTGGACCG
AGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAACACAGCCACAGCCAT
CATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAGGTCCCCGAAAACCGCGTGGAGACCGT
GGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAGTGGGGATCCATCCGG
GCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTCGACTACGAGCTCAACAGAGCTTTCAT
GCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGTGACCATCTCCATCAT
GGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTGCCCCCCGGCACCGTGCTGACCACGTT
TTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCTGCACATCAATGCCAC
CAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTCTACGAGGCCACCTTCCTGGCAGCTGA
CAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGA
GGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTT
CGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCT
GTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAA
GGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCT
CATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCT
CATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCA
GCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCA
GTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGC
ACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGG
GGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGAC
CTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGGACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGG
CTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCTAGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGC
CGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTGTCTTCACTTGAATTTCCTAGAACAGAAGCACTGTTTTT
AAAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAAAGAAAGTGCCTTTTGGTATGTATCAGATTCCCTCAAACTCAGGA
GTGTCTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGCCTCCAACCCCAGCTAGTCCCAGCTCTGAAGGCATCATTCAGAAA
TGGGGGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTATTAAGAAAAAGAAAGTGGGTGACTTGTTTGAAAACAGAGTGGGG
TTCAAATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGAGCCTCTTGGGAGTCAAGGCCAGCTGGGAGGCTTAGCCCTTCAGC
CCCAGCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACCTTGTGGCTGCTCCCCACCCCTCCCGGATGCTGTGAGGAGCTCAG
GCAGGGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACCCCCAGTCAACCCAGGCCTCCCTCAGGGACACCTGTCACCCTGAG
TGCCACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCCAAACCAGCCAGCATCTGGCTCCAGCCCTCCAACCCTGGCGACCA
GACCCCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCAAACCCCAGGACACTCTCGACAGCTCCAACCATCCGGAGGGCTGT
GCAGATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCAGTTACGGTTGGGCGTGGTGACCAGAACACACCCAGCAGCCTGCG
AAGCCTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCTTGTGAGCCTGTGTGGGTGGCAGGAGGCCCCGTCTTGCCGTGCCT
ACCTGTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCTCTCCTATGGACCCTCGTCGGGGGCAGGCAGCGGCCGGGTCCAAA
CTTGCTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGTTGACTCAAGCCAGACAGGGGGAAGGAATTGGTTCTGCAGGACAG
TGAGAGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCCTGTGCTCACTGCATGAGAAAACTCAGAGGGTGCATTCTCCCTCT
GGCATGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCCCCACGTGGGGAAGCCTCGTGCTTGGTCAGCTTTCTGTCTCTCCC
AGGCCAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGGGACCCTGGGCAGGACCTGGTGTCGGGCAGGGCGGTGCCAGCACT
GGGGAAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCACTGGGGTCAGGGAGTGTCTCGGGGTGCCTTTGGGGGCAGCATGA
GCTCCACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCCCATGGCTAAGGTCATGCCTTTTCTGAACAGCTTTGGCCTTGAGT
GCACACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAGGGTCCTTGTCCAAACCAAACTCACAGCTGCCCCTGTGCAGCCTT
CAGAGTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCCTCCCATGGCTGCCCAGGGAGGGCGGGGTTCACTGTGCCACGTGC
TGGGTGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACAGAGGTCAAGGGGCAGCTGGCCAGGCCGCACCGGGGTCCCCGAGT
TCTGAGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCATGGCCGTTGGAGGTATAGCTGGGCGGGTAGTGGAAGGACTGGAA
ATCTCTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGTATGCGTGGATTGTTCGAAGTGTGACTATGGCCCGGGAGCCAGGG
CAGCATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCCCTGAACTCCGGGCTGATGTTCCCAGGACCCAGCACCAGGAGACC
CCAGTCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACATTGGCCGCCTCCCACTAGCTCCCCCTCCTCGCCCACAGCCTCTTG
TCACTGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAAGCTGCAGTGCCAGCTGGAGGGATGTTCATAGGGCTTCCTGTGCC
CATCCCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCCTGGTGAGCCCCTGGGGGCCAGAGAAAGATGGGGTTCCTGCACCT
TCCCAGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACAATCAGTGTCGAACGTCTCTCTTCCTTAAGCTTGTAGATACGACT
GCCTATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTGGCCAGGTGCGAGGGCATGGTTTGGTTCCTTTAGGGAATTTTTGT
TTTGCAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAACGACTGGCCTTGGTCAGCAGGCAGCCCCCAGCCTAGGGCCACAGT
CCTCTTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTCTCTTTGTAGTGTCTTTCAGCACATCCAAAATGCTAGGCCTCCTG
CCACCAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGATGCCTCAGTTTCCCTAGCATGAGCACCAGCCGACACACACAGTCC
ACTGAGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAGGGGTAGTCTCAATTTCTGTCAGTGCTCAAAGGAATAACACCAAA
AGAATCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGCGCCGTGGGTCCGTAGGAGGGACAGTACCTCACAACAGGCCCAGC
GGGGGACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTTTCTCTCCTTTTTTCATTCCGATTTTTTTTGCATGTTTCTTTTTG
AAATGGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGGGGAAAGATACTGGAGTATGATGTACTCACACCTGCAAATCTGAG
CATCGCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGCACAACTATTTTGTATTGTTGTTTGTATCATTTTGTACCAAAAAA
AAAAAGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTTCCAGTGCCAGACAGTCTTGGTCCTGAACTCAGTAGACCCTTGCG

>57779_57779_1_NCOA5-CDH4_NCOA5_chr20_44708025_ENST00000290231_CDH4_chr20_60318618_ENST00000360469_length(amino acids)=842AA_BP=
MDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGL
RRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNG
NKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVA
AGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIIS
GDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGT
VLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPE
LLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTS
IIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQD
YDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLN

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>57779_57779_2_NCOA5-CDH4_NCOA5_chr20_44708026_ENST00000290231_CDH4_chr20_60318619_ENST00000360469_length(transcript)=6457nt_BP=203nt
CGGCCGCCATTGCCTCGTGCCCGCGCCGGTCGGTTGGTGGCGCCTTTGTCCTACGGCGGGCAGGTGGGCCGACGCGGAGGCGGCAGCGGC
GGGCCTGAGGCGAAGGAGCGGCCGGGAGCCCGCCGCGCTGGTAGCGATATTAATAAGGCAGCGGAAAGAAGAAATATGAATACGGCTCCA
TCAAGACCCAGCCCCACACGAAGTCAAGTTCAGCAGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAGCATGGACTTCAAAGT
TGGGGCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTCACGGTGACTGCATGGGACAGCCAGAC
AGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTGGTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCAGAAAGGAAAGAAGGT
CGTGGCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAACGCCAACGGGCTGAGGCGGCGCAAACG
GGACTGGGTCATCCCGCCCATCAACGTGCCCGAGAACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCGGTCCGACAAAGACAA
TGACATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTCAGCATTGACTCCATGTCCGGCCGGAT
GTACGTCACAAGGCCCATGGACCGGGAGGAGCACGCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGGCAACAAGGTGGAGAA
CCCCATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAGGTCTACAACGGCTCCGTGGACGAGGG
CTCCAAGCCAGGCACCTACGTGATGACCGTCACGGCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGTGCGGTACCGGATCGT
GACCCAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATCGTCACAGTGGCGGCTGGCCTGGACCG
AGAGAAAGTTCAGCAGTACACAGTCATCGTTCAGGCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAACACAGCCACAGCCAT
CATCACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAGGTCCCCGAAAACCGCGTGGAGACCGT
GGTCGCAAACCTCACGGTGATGGACCGAGATCAGCCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAGTGGGGATCCATCCGG
GCACTTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTCGACTACGAGCTCAACAGAGCTTTCAT
GCTGACAGTGATGGTGTCCAACCAGGCGCCCCTGGCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGTGACCATCTCCATCAT
GGACATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTGCCCCCCGGCACCGTGCTGACCACGTT
TTCAGCTGTGGACCCTGACCGGTTCATGCAGCAGGCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCTGCACATCAATGCCAC
CAACGGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTCTACGAGGCCACCTTCCTGGCAGCTGA
CAATGGGATACCCCCGGCCAGCGGCACCGGGACCCTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGA
GGCGCAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTCGACCCCAACATCGGCCCCTACGTCTT
CGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAGAACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCT
GTACCTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTGTCCAACACGTCCATCATCAAAGTCAA
GGTGTGCCCATGTGATGACAACGGGGACTGCACCACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCT
CATCTGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAGAAGGAGCGCCACACGAAGCAGCTGCT
CATTGACCCCGAGGACGACGTCCGCGACAACATCCTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCA
GCTGCAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGATGAGCGGCCGGTGGGCGCTGAGCCCCA
GTACCCGATCAGGCCCATGGTGCCGCACCCAGGCGACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGC
ACCCCCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTCAGCTCCCTGAACTCATCCAGTTCCGG
GGACCAAGACTACGATTACCTCAACGACTGGGGGCCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGATTGACTGAC
CTCGCATCTTCGGACCGAAGTGAGAGCCGTGCTCGGACGCCGGAGGAGCAGGACTGAGCAGAGGCGGCCGGTCTTCCCGACTCCCTGCGG
CTGTGTCCTTAGTGCTGTTAGGAGGCCCCCCAATCCCCACGTTGAGCTGTCTAGCATGAGCACCCACCCCCACAGCGCCCTGCACCCGGC
CGCTGCCCAGCACCGCGCTGGCTGGCACTGAAGGACAGCAAGAGGCACTCTGTCTTCACTTGAATTTCCTAGAACAGAAGCACTGTTTTT
AAAAAAAAAAAAAAAAAAAGAAGAAAGAAAGAAAAAAAAAAAAAAAAGAAAGTGCCTTTTGGTATGTATCAGATTCCCTCAAACTCAGGA
GTGTCTAAAGCAGACAGACCGTCCCCACCTTCCCATCCCGAGCGGCCTCCAACCCCAGCTAGTCCCAGCTCTGAAGGCATCATTCAGAAA
TGGGGGAGACTGTGTCTGTCTTTCTTACTTTTTTTTTGGTCTTTTATTAAGAAAAAGAAAGTGGGTGACTTGTTTGAAAACAGAGTGGGG
TTCAAATCCCAGCAGCCTTTGCTGTACACAGCTGGGGGTCTCTTGAGCCTCTTGGGAGTCAAGGCCAGCTGGGAGGCTTAGCCCTTCAGC
CCCAGCAGAAGGCCCTGGGGCTGGTGGGGCTCAGAATACCCCTACCTTGTGGCTGCTCCCCACCCCTCCCGGATGCTGTGAGGAGCTCAG
GCAGGGGCCTGGAGGGGAACAGGGGTCATCCTGAAGGGGCTCCACCCCCAGTCAACCCAGGCCTCCCTCAGGGACACCTGTCACCCTGAG
TGCCACCAGGTCCCCTCTGCCTTTGGTCCAGAAGAGTGAGTTGTCCAAACCAGCCAGCATCTGGCTCCAGCCCTCCAACCCTGGCGACCA
GACCCCATGGGGTGCCATCAACGGCCCCGCGACAGGCATCAATTCAAACCCCAGGACACTCTCGACAGCTCCAACCATCCGGAGGGCTGT
GCAGATGGCAGGAACCAAGGACCCTCCCTGGCAGCTGAAGAGGGCAGTTACGGTTGGGCGTGGTGACCAGAACACACCCAGCAGCCTGCG
AAGCCTCCCCGTCCCCAGCCTGTGCTCCTGATTCCCGCCAGACGCTTGTGAGCCTGTGTGGGTGGCAGGAGGCCCCGTCTTGCCGTGCCT
ACCTGTCGCACAGATGCCTCTGCACGCTGCAGACGGTGCCTCTCCTCTCCTATGGACCCTCGTCGGGGGCAGGCAGCGGCCGGGTCCAAA
CTTGCTGCTGTCCTCGAGGCTGGCACTGCTATCTCCAGGGCTGGGTTGACTCAAGCCAGACAGGGGGAAGGAATTGGTTCTGCAGGACAG
TGAGAGGGTCTGTGTCCCGGCACCCCTGGGACAGCGCTCGGCTGCCTGTGCTCACTGCATGAGAAAACTCAGAGGGTGCATTCTCCCTCT
GGCATGGCTGTGTCTGGGCGCCTTGGGCTGCGGCAGGGGGCAGGCCCCACGTGGGGAAGCCTCGTGCTTGGTCAGCTTTCTGTCTCTCCC
AGGCCAGTGACAACTGGCTTCCCGAGGAAGGAGGTGAGGTACCAGGGACCCTGGGCAGGACCTGGTGTCGGGCAGGGCGGTGCCAGCACT
GGGGAAGGACAGGGAGCCCTCCCGGAGCCCCACCCTGCACCTGCCACTGGGGTCAGGGAGTGTCTCGGGGTGCCTTTGGGGGCAGCATGA
GCTCCACCAGGGGCCCCGGCCCCCACCTCAGCCTATGGCCCTTCCCCATGGCTAAGGTCATGCCTTTTCTGAACAGCTTTGGCCTTGAGT
GCACACATCTGTGCCAGGCTCACGGCATGTTCCCGTTGGATGTCAGGGTCCTTGTCCAAACCAAACTCACAGCTGCCCCTGTGCAGCCTT
CAGAGTTGAGCTGGGGTCTCAGTCTCCAACCTGTCCTTTCTGACCCTCCCATGGCTGCCCAGGGAGGGCGGGGTTCACTGTGCCACGTGC
TGGGTGCCCCCCTCTGCAGACAGCCAGTCCAGGAGATGGACCAACAGAGGTCAAGGGGCAGCTGGCCAGGCCGCACCGGGGTCCCCGAGT
TCTGAGCTGTGCTATGCAAACAAGAATGCTCCTGTGTGGGGGGGCATGGCCGTTGGAGGTATAGCTGGGCGGGTAGTGGAAGGACTGGAA
ATCTCTGTTGTTGTTTGGGGAAGTCCATGCTTCAGTCCTTCGGAGTATGCGTGGATTGTTCGAAGTGTGACTATGGCCCGGGAGCCAGGG
CAGCATGAACTCCTTTCTCTGAAATTTCGAGGCCTCCTTGGGTTCCCTGAACTCCGGGCTGATGTTCCCAGGACCCAGCACCAGGAGACC
CCAGTCCCGCCAGCAGCCGCCGCTACCCAGGAGGGCTGGGCGACATTGGCCGCCTCCCACTAGCTCCCCCTCCTCGCCCACAGCCTCTTG
TCACTGCCAAGCCCCCGTTCCTTTTGCCCAAATCACGCAGGCGGAAGCTGCAGTGCCAGCTGGAGGGATGTTCATAGGGCTTCCTGTGCC
CATCCCTGCTCCAAACAGCTGGACAGCTTCCCCTCTACCCCCACCCTGGTGAGCCCCTGGGGGCCAGAGAAAGATGGGGTTCCTGCACCT
TCCCAGCTCCACCTCTGAACTTGAGTTAGCGTTAGCTAAGCATACAATCAGTGTCGAACGTCTCTCTTCCTTAAGCTTGTAGATACGACT
GCCTATAATCAGGGGACTCCCACTGGAGGCCGGGAGGCCAATGCTGGCCAGGTGCGAGGGCATGGTTTGGTTCCTTTAGGGAATTTTTGT
TTTGCAAACAGGAGAAACCTGTGCTGCAGGTTGGAGTGGCAGGAACGACTGGCCTTGGTCAGCAGGCAGCCCCCAGCCTAGGGCCACAGT
CCTCTTCAGGGCCTGGGCAGCCCCAATTTCTGGCCCAGCAGGTTTCTCTTTGTAGTGTCTTTCAGCACATCCAAAATGCTAGGCCTCCTG
CCACCAACGTGTCAGAGCAATGTCCAACTGTCAGGCTCTCAGAGATGCCTCAGTTTCCCTAGCATGAGCACCAGCCGACACACACAGTCC
ACTGAGATGATAATTCTGTTCTCTCCAAAGCAAAAAGCTGGGCGAGGGGTAGTCTCAATTTCTGTCAGTGCTCAAAGGAATAACACCAAA
AGAATCAACACAGAATCTCCCAGACACACGTGACCCAGCTCGTGGCGCCGTGGGTCCGTAGGAGGGACAGTACCTCACAACAGGCCCAGC
GGGGGACCACCTCTCTGTACAATTGGAATGCGTTTTACTTTTCTTTTCTCTCCTTTTTTCATTCCGATTTTTTTTGCATGTTTCTTTTTG
AAATGGGCAAAATGTGTAGCAGCCTGCATGAGCACAGTTGTTTTGGGGAAAGATACTGGAGTATGATGTACTCACACCTGCAAATCTGAG
CATCGCGAGGTTAAACGTTCCACCTTTTTTTGTAATCGTCAACAGCACAACTATTTTGTATTGTTGTTTGTATCATTTTGTACCAAAAAA
AAAAAGGAAAAAAAAAGGGAAGAGAGTTGATGTTTTCAGTGTGTTTCCAGTGCCAGACAGTCTTGGTCCTGAACTCAGTAGACCCTTGCG

>57779_57779_2_NCOA5-CDH4_NCOA5_chr20_44708026_ENST00000290231_CDH4_chr20_60318619_ENST00000360469_length(amino acids)=842AA_BP=
MDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGL
RRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMNG
NKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVA
AGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPNWNAVYRIIS
GDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGT
VLTTFSAVDPDRFMQQAVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPE
LLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTS
IIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQD
YDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLN

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Fusion Gene PPI Analysis for NCOA5-CDH4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOA5-CDH4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOA5-CDH4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource