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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOA7-NKAIN2 (FusionGDB2 ID:57813)

Fusion Gene Summary for NCOA7-NKAIN2

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOA7-NKAIN2
Fusion gene ID: 57813
HgeneTgene
Gene symbol

NCOA7

NKAIN2

Gene ID

135112

154215

Gene namenuclear receptor coactivator 7sodium/potassium transporting ATPase interacting 2
SynonymsERAP140|ESNA1|NCOA7-AS|Nbla00052|Nbla10993|TLDC4|dJ187J11.3FAM77B|NKAIP2|TCBA|TCBA1
Cytomap

6q22.31-q22.32

6q22.31

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor coactivator 7140 kDa estrogen receptor-associated proteinTBC/LysM-associated domain containing 4estrogen nuclear receptor coactivator 1estrogen receptor associated protein 140 kDaputative protein product of Nbla00052putative proteinsodium/potassium-transporting ATPase subunit beta-1-interacting protein 2Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 2Na+/K+ transporting ATPase interacting 2T-cell lymphoma breakpoint-associated target protein 1
Modification date2020031320200313
UniProtAcc

Q8NI08

Q5VXU1

Ensembl transtripts involved in fusion geneENST00000229634, ENST00000368357, 
ENST00000392477, ENST00000487635, 
ENST00000368416, ENST00000368417, 
ENST00000476571, ENST00000545433, 
ENST00000546092, 
Fusion gene scores* DoF score14 X 9 X 7=88214 X 12 X 7=1176
# samples 1518
** MAII scorelog2(15/882*10)=-2.55581615506164
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1176*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOA7 [Title/Abstract] AND NKAIN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOA7(126112213)-NKAIN2(125112485), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOA7

GO:0045944

positive regulation of transcription by RNA polymerase II

11971969


check buttonFusion gene breakpoints across NCOA7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across NKAIN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-L5-A891-01ANCOA7chr6

126112213

-NKAIN2chr6

125112485

+
ChimerDB4ESCATCGA-L5-A891-01ANCOA7chr6

126112213

+NKAIN2chr6

125112485

+
ChimerDB4ESCATCGA-L5-A891NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
ChimerDB4ESCATCGA-L5-A891NCOA7chr6

126112213

+NKAIN2chr6

125112485

+


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Fusion Gene ORF analysis for NCOA7-NKAIN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000229634ENST00000368416NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000229634ENST00000368417NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000229634ENST00000476571NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000229634ENST00000545433NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000229634ENST00000546092NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000368357ENST00000368416NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
5UTR-intronENST00000368357ENST00000368417NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
5UTR-intronENST00000368357ENST00000476571NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
5UTR-intronENST00000368357ENST00000545433NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
5UTR-intronENST00000368357ENST00000546092NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
5UTR-intronENST00000392477ENST00000368416NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000392477ENST00000368417NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000392477ENST00000476571NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000392477ENST00000545433NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
5UTR-intronENST00000392477ENST00000546092NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000229634ENST00000368416NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000229634ENST00000368417NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000229634ENST00000476571NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000229634ENST00000545433NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000229634ENST00000546092NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000368357ENST00000368416NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000368357ENST00000368417NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000368357ENST00000476571NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000368357ENST00000545433NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000368357ENST00000546092NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000392477ENST00000368416NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000392477ENST00000368417NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000392477ENST00000476571NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000392477ENST00000545433NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000392477ENST00000546092NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000368416NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000368416NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000368417NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000368417NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000476571NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000476571NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000545433NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000545433NCOA7chr6

126107359

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000546092NCOA7chr6

126112213

+NKAIN2chr6

125112485

+
intron-intronENST00000487635ENST00000546092NCOA7chr6

126107359

+NKAIN2chr6

125112485

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NCOA7-NKAIN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOA7chr6126107359+NKAIN2chr6125112484+0.206870020.79313
NCOA7chr6126112213+NKAIN2chr6125112484+9.29E-060.9999907
NCOA7chr6126112213+NKAIN2chr6125112484+9.29E-060.9999907
NCOA7chr6126107359+NKAIN2chr6125112484+0.206870020.79313
NCOA7chr6126112213+NKAIN2chr6125112484+9.29E-060.9999907
NCOA7chr6126112213+NKAIN2chr6125112484+9.29E-060.9999907

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCOA7-NKAIN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:126112213/:125112485)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOA7

Q8NI08

NKAIN2

Q5VXU1

FUNCTION: Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. {ECO:0000269|PubMed:11971969}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NCOA7-NKAIN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NCOA7-NKAIN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOA7-NKAIN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOA7-NKAIN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource