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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOR1-CYP2C9 (FusionGDB2 ID:57831)

Fusion Gene Summary for NCOR1-CYP2C9

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1-CYP2C9
Fusion gene ID: 57831
HgeneTgene
Gene symbol

NCOR1

CYP2C9

Gene ID

9611

1559

Gene namenuclear receptor corepressor 1cytochrome P450 family 2 subfamily C member 9
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoRCPC9|CYP2C|CYP2C10|CYPIIC9|P450IIC9
Cytomap

17p12-p11.2

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1cytochrome P450 2C9cytochrome P-450 S-mephenytoin 4-hydroxylasecytochrome P-450MPcytochrome P450 PB-1cytochrome P450, family 2, subfamily C, polypeptide 9flavoprotein-linked monooxygenasemicrosomal monooxygenasexenobiotic monooxygenase
Modification date2020031320200313
UniProtAcc

O75376

P11712

Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395848, 
ENST00000395851, ENST00000583226, 
ENST00000395857, 		ENST00000461906, 
ENST00000260682, 
Fusion gene scores* DoF score30 X 30 X 13=117004 X 3 X 3=36
# samples 334
** MAII scorelog2(33/11700*10)=-5.14789869511231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NCOR1 [Title/Abstract] AND CYP2C9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOR1(16021201)-CYP2C9(96701614), # samples:1
Anticipated loss of major functional domain due to fusion event.NCOR1-CYP2C9 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR1-CYP2C9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR1-CYP2C9 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NCOR1-CYP2C9 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768

TgeneCYP2C9

GO:0008210

estrogen metabolic process

12865317

TgeneCYP2C9

GO:0016098

monoterpenoid metabolic process

16401082

TgeneCYP2C9

GO:0017144

drug metabolic process

19219744|19651758

TgeneCYP2C9

GO:0019373

epoxygenase P450 pathway

7574697

TgeneCYP2C9

GO:0019627

urea metabolic process

19029318

TgeneCYP2C9

GO:0032787

monocarboxylic acid metabolic process

19651758

TgeneCYP2C9

GO:0042738

exogenous drug catabolic process

18619574

TgeneCYP2C9

GO:0043603

cellular amide metabolic process

19651758

TgeneCYP2C9

GO:0046456

icosanoid biosynthetic process

15766564

TgeneCYP2C9

GO:0055114

oxidation-reduction process

16401082|19219744

TgeneCYP2C9

GO:0070989

oxidative demethylation

18619574


check buttonFusion gene breakpoints across NCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYP2C9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer203NNCOR1chr17

16021201

-CYP2C9chr10

96701614

+


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Fusion Gene ORF analysis for NCOR1-CYP2C9

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000268712ENST00000461906NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
5CDS-3UTRENST00000395848ENST00000461906NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
5CDS-3UTRENST00000395851ENST00000461906NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
5UTR-3CDSENST00000583226ENST00000260682NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
5UTR-3UTRENST00000583226ENST00000461906NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
Frame-shiftENST00000268712ENST00000260682NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
In-frameENST00000395848ENST00000260682NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
In-frameENST00000395851ENST00000260682NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
intron-3CDSENST00000395857ENST00000260682NCOR1chr17

16021201

-CYP2C9chr10

96701614

+
intron-3UTRENST00000395857ENST00000461906NCOR1chr17

16021201

-CYP2C9chr10

96701614

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000395851NCOR1chr1716021201-ENST00000260682CYP2C9chr1096701614+376620992034031127
ENST00000395848NCOR1chr1716021201-ENST00000260682CYP2C9chr1096701614+346517984631021018

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000395851ENST00000260682NCOR1chr1716021201-CYP2C9chr1096701614+0.0005899760.99941003
ENST00000395848ENST00000260682NCOR1chr1716021201-CYP2C9chr1096701614+0.0005992250.99940073

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Fusion Genomic Features for NCOR1-CYP2C9


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOR1chr1716021201-CYP2C9chr1096701614+0.0212229420.9787771
NCOR1chr1716021201-CYP2C9chr1096701614+0.0212229420.9787771

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCOR1-CYP2C9


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:16021201/chr10:96701614)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

CYP2C9

P11712

FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:9866708, PubMed:9435160, PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:7574697, PubMed:15766564, PubMed:19965576, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9866708, PubMed:9435160). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031). {ECO:0000269|PubMed:11950794, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:25994031, ECO:0000269|PubMed:7574697, ECO:0000269|PubMed:9435160, ECO:0000269|PubMed:9866708}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846174_2166852441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846299_3286852441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846501_5576852441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519174_216576915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519299_328576915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519501_557576915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745174_2166852338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745299_3286852338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745501_5576852338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-184658_646852441.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846593_6036852441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846607_6176852441.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-151958_64576915.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-174558_646852338.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745593_6036852338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745607_6176852338.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846435_4866852441.0DomainSANT 1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846623_6746852441.0DomainSANT 2
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519435_486576915.0DomainSANT 1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745435_4866852338.0DomainSANT 1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745623_6746852338.0DomainSANT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18461032_10356852441.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18461707_17126852441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18461952_19636852441.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15191032_1035576915.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15191707_1712576915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15191952_1963576915.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519593_603576915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519607_617576915.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17451032_10356852338.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17451707_17126852338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17451952_19636852338.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519623_674576915.0DomainSANT 2
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18461933_19376852441.0MotifNote=CORNR box 1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18462055_20596852441.0MotifNote=CORNR box 2
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18462263_22676852441.0MotifNote=CORNR box 3
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15191933_1937576915.0MotifNote=CORNR box 1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15192055_2059576915.0MotifNote=CORNR box 2
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15192263_2267576915.0MotifNote=CORNR box 3
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17451933_19376852338.0MotifNote=CORNR box 1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17452055_20596852338.0MotifNote=CORNR box 2
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17452263_22676852338.0MotifNote=CORNR box 3
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18462032_21156852441.0RegionID1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18462212_22736852441.0RegionID2
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15192032_2115576915.0RegionID1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15192212_2273576915.0RegionID2
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17452032_21156852338.0RegionID1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17452212_22736852338.0RegionID2


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Fusion Gene Sequence for NCOR1-CYP2C9


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57831_57831_1_NCOR1-CYP2C9_NCOR1_chr17_16021201_ENST00000395848_CYP2C9_chr10_96701614_ENST00000260682_length(transcript)=3465nt_BP=1798nt
GTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCAGGTTATCC
TCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCACCAGCAGGA
TCCAGCATTCGGAGGCAAACATGAAGCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACT
CTCAAAGGAAGAGTTAATACAGAGTATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACA
ACAACAGCTTGAAGAAGAGGCAGCTAAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGT
CCAAATTATTTATGATGAGAATCGGAAAAAAGCAGAAGAAGCTCATAAAATTTTTGAAGGTCTTGGCCCAAAAGTTGAACTGCCACTGTA
TAACCAGCCATCAGATACCAAGGTGTACCATGAGAACATCAAGACAAACCAGGTGATGAGGAAAAAACTCATTTTATTTTTTAAAAGAAG
AAATCATGCAAGAAAACAAAGGGAACAAAAAATCTGCCAGCGTTATGATCAGCTCATGGAGGCATGGGAGAAAAAAGTGGACAGAATAGA
AAATAATCCTCGGAGGAAAGCTAAAGAAAGCAAAACAAGGGAATACTATGAAAAGCAGTTTCCAGAAATTCGAAAACAAAGAGAACAGCA
AGAAAGATTTCAGCGAGTTGGGCAGAGGGGAGCTGGTCTTTCAGCCACCATTGCTAGGAGTGAGCATGAGATTTCTGAAATTATTGATGG
GCTCTCTGAGCAGGAGAATAATGAGAAACAAATGCGGCAGCTCTCTGTGATTCCACCTATGATGTTTGATGCAGAACAAAGACGAGTCAA
GTTCATTAACATGAATGGGCTTATGGAGGACCCTATGAAAGTGTATAAAGATAGGCAGTTTATGAATGTTTGGACTGACCATGAAAAGGA
GATCTTTAAGGACAAGTTTATCCAGCATCCAAAAAACTTTGGACTAATTGCATCATACTTGGAGAGGAAGAGTGTTCCTGATTGTGTTTT
GTATTACTATTTAACCAAGAAAAATGAGAATTATAAAGCCCTCGTCAGAAGGAATTATGGGAAACGCAGAGGCAGAAACCAGCAAATTGC
TCGACCCTCGCAAGAAGAAAAAGTAGAAGAAAAAGAAGAGGATAAAGCAGAAAAAACAGAAAAAAAAGAAGAAGAAAAGAAAGATGAAGA
GGAAAAAGATGAAAAAGAAGACTCCAAAGAAAATACCAAGGAAAAGGACAAGATAGATGGTACAGCAGAAGAAACTGAGGAAAGAGAGCA
AGCCACACCCCGGGGGCGAAAGACTGCCAACAGTCAGGGCCGCCGTAAGGGCCGGATCACCAGGTCCATGACAAACGAAGCTGCAGCTGC
CAGTGCTGCAGCCGCAGCGGCTACTGAAGAGCCCCCACCACCTCTGCCACCGCCACCAGAACCCATTTCTACAGAGCCTGTGGAGACCTC
TCGATGGACAGAAGAAGAAATGGAAGTTGCTAAAAAAGGTCTAGTAGAACATGGTCGTAACTGGGCAGCAATTGCTAAAATGGTGGGAAC
GAAAAGTGAAGCTCAATGTAAAAACTTCTATTTTAACTATAAAAGGCGACACAATCTTGACAACCTCTTACAGCAGCATAAACAGAAACT
CTCAAAGGTCTATGGCCCTGTGTTCACTCTGTATTTTGGCCTGAAACCCATAGTGGTGCTGCATGGATATGAAGCAGTGAAGGAAGCCCT
GATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCATTTTCCCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATTGTTTTCAGCAATGG
AAAGAAATGGAAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGCATTGAGGACCGTGTTCAAGA
GGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAGGCCTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGT
GATCTGCTCCATTATTTTCCATAAACGTTTTGATTATAAAGATCAGCAATTTCTTAACTTAATGGAAAAGTTGAATGAAAACATCAAGAT
TTTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCTCCTATCATTGATTACTTCCCGGGAACTCACAACAAATTACTTAAAAACGT
TGCTTTTATGAAAAGTTATATTTTGGAAAAAGTAAAAGAACACCAAGAATCAATGGACATGAACAACCCTCAGGACTTTATTGATTGCTT
CCTGATGAAAATGGAGAAGGAAAAGCACAACCAACCATCTGAATTTACTATTGAAAGCTTGGAAAACACTGCAGTTGACTTGTTTGGAGC
TGGGACAGAGACGACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACAGCTAAAGTCCAGGAAGAGAT
TGAACGTGTGATTGGCAGAAACCGGAGCCCCTGCATGCAAGACAGGAGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAG
ATACATTGACCTTCTCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACATTAAATTCAGAAACTATCTCATTCCCAAGGGCACAACCAT
ATTAATTTCCCTGACTTCTGTGCTACATGACAACAAAGAATTTCCCAACCCAGAGATGTTTGACCCTCATCACTTTCTGGATGAAGGTGG
CAATTTTAAGAAAAGTAAATACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAAGCCCTGGCCGGCATGGAGCTGTTTTT
ATTCCTGACCTCCATTTTACAGAACTTTAACCTGAAATCTCTGGTTGACCCAAAGAACCTTGACACCACTCCAGTTGTCAATGGATTTGC
CTCTGTGCCGCCCTTCTACCAGCTGTGCTTCATTCCTGTCTGAAGAAGAGCAGATGGCCTGGCTGCTGCTGTGCAGTCCCTGCAGCTCTC
TTTCCTCTGGGGCATTATCCATCTTTCACTATCTGTAATGCCTTTTCTCACCTGTCATCTCACATTTTCCCTTCCCTGAAGATCTAGTGA
ACATTCGACCTCCATTACGGAGAGTTTCCTATGTTTCACTGTGCAAATATATCTGCTATTCTCCATACTCTGTAACAGTTGCATTGACTG
TCACATAATGCTCATACTTATCTAATGTTGAGTTATTAATATGTTATTATTAAATAGAGAAATATGATTTGTGTATTATAATTCAAAGGC

>57831_57831_1_NCOR1-CYP2C9_NCOR1_chr17_16021201_ENST00000395848_CYP2C9_chr10_96701614_ENST00000260682_length(amino acids)=1018AA_BP=584
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQDPAFGGKHEAPSSPISGQPCGDDQNASPSKLSKEELIQSMDRVDRE
IAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVELPLYNQPSDTKVYHENIKT
NQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQREQQERFQRVGQRGAGLSA
TIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTDHEKEIFKDKFIQHPKNFGL
IASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEKKDEEEKDEKEDSKENTKEK
DKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEPVETSRWTEEEMEVAKKGLV
EHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPL
AERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQ
QFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEF
TIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC
DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLV

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>57831_57831_2_NCOR1-CYP2C9_NCOR1_chr17_16021201_ENST00000395851_CYP2C9_chr10_96701614_ENST00000260682_length(transcript)=3766nt_BP=2099nt
ATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCAGGTTATCCTCCCAACCAAGGAGCATTCAGCACAG
AACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCACCAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCT
CTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAGCTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTC
ACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCAGGCCCATCCCCAGTGGATCATGATTCACTGGAAT
CGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCTGCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAG
GGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAAGCTCCATCCTCTCCAATTTCGGGGCAACCATGTG
GAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGTATGGATCGTGTAGATCGAGAAATTGCAAAAGTAG
AACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCTAAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTC
CTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGGAAAAAAGCAGAAGAAGCTCATAAAATTTTTGAAG
GTCTTGGCCCAAAAGTTGAACTGCCACTGTATAACCAGCCATCAGATACCAAGGTGTACCATGAGAACATCAAGACAAACCAGGTGATGA
GGAAAAAACTCATTTTATTTTTTAAAAGAAGAAATCATGCAAGAAAACAAAGGGAACAAAAAATCTGCCAGCGTTATGATCAGCTCATGG
AGGCATGGGAGAAAAAAGTGGACAGAATAGAAAATAATCCTCGGAGGAAAGCTAAAGAAAGCAAAACAAGGGAATACTATGAAAAGCAGT
TTCCAGAAATTCGAAAACAAAGAGAACAGCAAGAAAGATTTCAGCGAGTTGGGCAGAGGGGAGCTGGTCTTTCAGCCACCATTGCTAGGA
GTGAGCATGAGATTTCTGAAATTATTGATGGGCTCTCTGAGCAGGAGAATAATGAGAAACAAATGCGGCAGCTCTCTGTGATTCCACCTA
TGATGTTTGATGCAGAACAAAGACGAGTCAAGTTCATTAACATGAATGGGCTTATGGAGGACCCTATGAAAGTGTATAAAGATAGGCAGT
TTATGAATGTTTGGACTGACCATGAAAAGGAGATCTTTAAGGACAAGTTTATCCAGCATCCAAAAAACTTTGGACTAATTGCATCATACT
TGGAGAGGAAGAGTGTTCCTGATTGTGTTTTGTATTACTATTTAACCAAGAAAAATGAGAATTATAAAGCCCTCGTCAGAAGGAATTATG
GGAAACGCAGAGGCAGAAACCAGCAAATTGCTCGACCCTCGCAAGAAGAAAAAGTAGAAGAAAAAGAAGAGGATAAAGCAGAAAAAACAG
AAAAAAAAGAAGAAGAAAAGAAAGATGAAGAGGAAAAAGATGAAAAAGAAGACTCCAAAGAAAATACCAAGGAAAAGGACAAGATAGATG
GTACAGCAGAAGAAACTGAGGAAAGAGAGCAAGCCACACCCCGGGGGCGAAAGACTGCCAACAGTCAGGGCCGCCGTAAGGGCCGGATCA
CCAGGTCCATGACAAACGAAGCTGCAGCTGCCAGTGCTGCAGCCGCAGCGGCTACTGAAGAGCCCCCACCACCTCTGCCACCGCCACCAG
AACCCATTTCTACAGAGCCTGTGGAGACCTCTCGATGGACAGAAGAAGAAATGGAAGTTGCTAAAAAAGGTCTAGTAGAACATGGTCGTA
ACTGGGCAGCAATTGCTAAAATGGTGGGAACGAAAAGTGAAGCTCAATGTAAAAACTTCTATTTTAACTATAAAAGGCGACACAATCTTG
ACAACCTCTTACAGCAGCATAAACAGAAACTCTCAAAGGTCTATGGCCCTGTGTTCACTCTGTATTTTGGCCTGAAACCCATAGTGGTGC
TGCATGGATATGAAGCAGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCATTTTCCCACTGGCTGAAAGAGCTA
ACAGAGGATTTGGAATTGTTTTCAGCAATGGAAAGAAATGGAAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGG
GGAAGAGGAGCATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAGGCCTCACCCTGTGATCCCA
CTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCCATTATTTTCCATAAACGTTTTGATTATAAAGATCAGCAATTTCTTAACT
TAATGGAAAAGTTGAATGAAAACATCAAGATTTTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCTCCTATCATTGATTACTTCC
CGGGAACTCACAACAAATTACTTAAAAACGTTGCTTTTATGAAAAGTTATATTTTGGAAAAAGTAAAAGAACACCAAGAATCAATGGACA
TGAACAACCCTCAGGACTTTATTGATTGCTTCCTGATGAAAATGGAGAAGGAAAAGCACAACCAACCATCTGAATTTACTATTGAAAGCT
TGGAAAACACTGCAGTTGACTTGTTTGGAGCTGGGACAGAGACGACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACC
CAGAGGTCACAGCTAAAGTCCAGGAAGAGATTGAACGTGTGATTGGCAGAAACCGGAGCCCCTGCATGCAAGACAGGAGCCACATGCCCT
ACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATTGACCTTCTCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACATTAAATTCA
GAAACTATCTCATTCCCAAGGGCACAACCATATTAATTTCCCTGACTTCTGTGCTACATGACAACAAAGAATTTCCCAACCCAGAGATGT
TTGACCCTCATCACTTTCTGGATGAAGGTGGCAATTTTAAGAAAAGTAAATACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGG
GAGAAGCCCTGGCCGGCATGGAGCTGTTTTTATTCCTGACCTCCATTTTACAGAACTTTAACCTGAAATCTCTGGTTGACCCAAAGAACC
TTGACACCACTCCAGTTGTCAATGGATTTGCCTCTGTGCCGCCCTTCTACCAGCTGTGCTTCATTCCTGTCTGAAGAAGAGCAGATGGCC
TGGCTGCTGCTGTGCAGTCCCTGCAGCTCTCTTTCCTCTGGGGCATTATCCATCTTTCACTATCTGTAATGCCTTTTCTCACCTGTCATC
TCACATTTTCCCTTCCCTGAAGATCTAGTGAACATTCGACCTCCATTACGGAGAGTTTCCTATGTTTCACTGTGCAAATATATCTGCTAT
TCTCCATACTCTGTAACAGTTGCATTGACTGTCACATAATGCTCATACTTATCTAATGTTGAGTTATTAATATGTTATTATTAAATAGAG

>57831_57831_2_NCOR1-CYP2C9_NCOR1_chr17_16021201_ENST00000395851_CYP2C9_chr10_96701614_ENST00000260682_length(amino acids)=1127AA_BP=693
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS
PSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAKPPEPEKPVSPPPVEQKHRSIVQIIYDENRKKAEEAHKIFEGLGPKVE
LPLYNQPSDTKVYHENIKTNQVMRKKLILFFKRRNHARKQREQKICQRYDQLMEAWEKKVDRIENNPRRKAKESKTREYYEKQFPEIRKQ
REQQERFQRVGQRGAGLSATIARSEHEISEIIDGLSEQENNEKQMRQLSVIPPMMFDAEQRRVKFINMNGLMEDPMKVYKDRQFMNVWTD
HEKEIFKDKFIQHPKNFGLIASYLERKSVPDCVLYYYLTKKNENYKALVRRNYGKRRGRNQQIARPSQEEKVEEKEEDKAEKTEKKEEEK
KDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQATPRGRKTANSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPPPEPISTEP
VETSRWTEEEMEVAKKGLVEHGRNWAAIAKMVGTKSEAQCKNFYFNYKRRHNLDNLLQQHKQKLSKVYGPVFTLYFGLKPIVVLHGYEAV
KEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCA
PCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDF
IDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVH
EVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGM

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Fusion Gene PPI Analysis for NCOR1-CYP2C9


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846254_312685.02441.0SIN3A/B
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519254_312576.0915.0SIN3A/B
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745254_312685.02338.0SIN3A/B
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18461_373685.02441.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15191_373576.0915.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17451_373685.02338.0ZBTB33 and HEXIM1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-18461501_2440685.02441.0C1D
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-15191501_2440576.0915.0C1D
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-17451501_2440685.02338.0C1D
HgeneNCOR1chr17:16021201chr10:96701614ENST00000268712-1846988_1816685.02441.0ETO
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395848-1519988_1816576.0915.0ETO
HgeneNCOR1chr17:16021201chr10:96701614ENST00000395851-1745988_1816685.02338.0ETO


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOR1-CYP2C9


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOR1-CYP2C9


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource