FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NCOR1-PIGL (FusionGDB2 ID:57841)

Fusion Gene Summary for NCOR1-PIGL

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR1-PIGL
Fusion gene ID: 57841
HgeneTgene
Gene symbol

NCOR1

PIGL

Gene ID

9611

9487

Gene namenuclear receptor corepressor 1phosphatidylinositol glycan anchor biosynthesis class L
SynonymsN-CoR|N-CoR1|PPP1R109|TRAC1|hN-CoRCHIME
Cytomap

17p12-p11.2

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 1protein phosphatase 1, regulatory subunit 109thyroid hormone- and retinoic acid receptor-associated corepressor 1N-acetylglucosaminyl-phosphatidylinositol de-N-acetylaseN-acetylglucosaminylphosphatidylinositol deacetylasePIG-Lphosphatidylinositol glycan, class Lphosphatidylinositol-glycan biosynthesis class L protein
Modification date2020031320200313
UniProtAcc

O75376

.
Ensembl transtripts involved in fusion geneENST00000268712, ENST00000395848, 
ENST00000395851, ENST00000395857, 
ENST00000583226, 		ENST00000463810, 
ENST00000225609, ENST00000395844, 
ENST00000498772, ENST00000581006, 
Fusion gene scores* DoF score30 X 30 X 13=117008 X 7 X 7=392
# samples 3310
** MAII scorelog2(33/11700*10)=-5.14789869511231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/392*10)=-1.97085365434048
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR1 [Title/Abstract] AND PIGL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOR1(16062074)-PIGL(16203202), # samples:1
NCOR1(16049557)-PIGL(16214936), # samples:1
Anticipated loss of major functional domain due to fusion event.NCOR1-PIGL seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR1-PIGL seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR1-PIGL seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NCOR1-PIGL seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCOR1

GO:0046329

negative regulation of JNK cascade

11931768


check buttonFusion gene breakpoints across NCOR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PIGL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4READTCGA-F5-6864-01ANCOR1chr17

16062074

-PIGLchr17

16203202

+
ChiTaRS5.0N/AAA593152NCOR1chr17

16049557

+PIGLchr17

16214936

+


Top

Fusion Gene ORF analysis for NCOR1-PIGL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000268712ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
5CDS-intronENST00000395848ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
5CDS-intronENST00000395851ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395848ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395848ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395848ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395848ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395851ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395851ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395851ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
Frame-shiftENST00000395851ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
In-frameENST00000268712ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
In-frameENST00000268712ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
In-frameENST00000268712ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
In-frameENST00000268712ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000395857ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000395857ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000395857ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000395857ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000583226ENST00000225609NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000583226ENST00000395844NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000583226ENST00000498772NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-3CDSENST00000583226ENST00000581006NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-intronENST00000268712ENST00000225609NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000268712ENST00000395844NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000268712ENST00000463810NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000268712ENST00000498772NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000268712ENST00000581006NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395848ENST00000225609NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395848ENST00000395844NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395848ENST00000463810NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395848ENST00000498772NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395848ENST00000581006NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395851ENST00000225609NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395851ENST00000395844NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395851ENST00000463810NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395851ENST00000498772NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395851ENST00000581006NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395857ENST00000225609NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395857ENST00000395844NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395857ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-intronENST00000395857ENST00000463810NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395857ENST00000498772NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000395857ENST00000581006NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000583226ENST00000225609NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000583226ENST00000395844NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000583226ENST00000463810NCOR1chr17

16062074

-PIGLchr17

16203202

+
intron-intronENST00000583226ENST00000463810NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000583226ENST00000498772NCOR1chr17

16049557

+PIGLchr17

16214936

+
intron-intronENST00000583226ENST00000581006NCOR1chr17

16049557

+PIGLchr17

16214936

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000268712NCOR1chr1716062074-ENST00000581006PIGLchr1716203202+11919902341004256
ENST00000268712NCOR1chr1716062074-ENST00000498772PIGLchr1716203202+15849902341004256
ENST00000268712NCOR1chr1716062074-ENST00000225609PIGLchr1716203202+17759902341004256
ENST00000268712NCOR1chr1716062074-ENST00000395844PIGLchr1716203202+18959902341004256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000268712ENST00000581006NCOR1chr1716062074-PIGLchr1716203202+0.0019773450.9980227
ENST00000268712ENST00000498772NCOR1chr1716062074-PIGLchr1716203202+0.0026801670.9973199
ENST00000268712ENST00000225609NCOR1chr1716062074-PIGLchr1716203202+0.0037546860.9962453
ENST00000268712ENST00000395844NCOR1chr1716062074-PIGLchr1716203202+0.002089620.9979103

Top

Fusion Genomic Features for NCOR1-PIGL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOR1chr1716062073-PIGLchr1716203201+3.44E-111
NCOR1chr1716062073-PIGLchr1716203201+3.44E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for NCOR1-PIGL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:16062074/chr17:16203202)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR1

O75376

.
FUNCTION: Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). {ECO:0000250|UniProtKB:Q60974, ECO:0000269|PubMed:14527417, ECO:0000269|PubMed:20812024}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646174_2162442441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545174_2162442338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-64658_642442441.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-31958_64135915.0Compositional biasNote=Poly-Gln
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-54558_642442338.0Compositional biasNote=Poly-Gln

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646299_3282442441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646501_5572442441.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319174_216135915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319299_328135915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319501_557135915.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545299_3282442338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545501_5572442338.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461032_10352442441.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461707_17122442441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461952_19632442441.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646593_6032442441.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646607_6172442441.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191032_1035135915.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191707_1712135915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191952_1963135915.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319593_603135915.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319607_617135915.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451032_10352442338.0Compositional biasNote=Poly-Pro
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451707_17122442338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451952_19632442338.0Compositional biasNote=Poly-Ser
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545593_6032442338.0Compositional biasNote=Poly-Ala
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545607_6172442338.0Compositional biasNote=Pro-rich
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646435_4862442441.0DomainSANT 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646623_6742442441.0DomainSANT 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319435_486135915.0DomainSANT 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319623_674135915.0DomainSANT 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545435_4862442338.0DomainSANT 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545623_6742442338.0DomainSANT 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461933_19372442441.0MotifNote=CORNR box 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6462055_20592442441.0MotifNote=CORNR box 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6462263_22672442441.0MotifNote=CORNR box 3
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191933_1937135915.0MotifNote=CORNR box 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3192055_2059135915.0MotifNote=CORNR box 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3192263_2267135915.0MotifNote=CORNR box 3
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451933_19372442338.0MotifNote=CORNR box 1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5452055_20592442338.0MotifNote=CORNR box 2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5452263_22672442338.0MotifNote=CORNR box 3
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6462032_21152442441.0RegionID1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6462212_22732442441.0RegionID2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3192032_2115135915.0RegionID1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3192212_2273135915.0RegionID2
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5452032_21152442338.0RegionID1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5452212_22732442338.0RegionID2
TgenePIGLchr17:16062074chr17:16203202ENST000002256091723_252111253.0Topological domainCytoplasmic
TgenePIGLchr17:16062074chr17:16203202ENST00000225609172_22111253.0TransmembraneHelical


Top

Fusion Gene Sequence for NCOR1-PIGL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57841_57841_1_NCOR1-PIGL_NCOR1_chr17_16062074_ENST00000268712_PIGL_chr17_16203202_ENST00000225609_length(transcript)=1775nt_BP=990nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
GGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCT
GGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAA
GTTACCTAAAGGGTGCTCTGTGCTCACGCTTCAGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCT
TCATACGCAGGATGTCCTCTTCGTGCTCAACAGCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTG
GTTCCGCCGCCTCTACATTATCTTCTCCCGGTACATGAGAATCAACTCACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAG
GAACAAAGGGGAAAATAGACAAAGGAGTGCAGAGGACCTGGCCTGGCACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCA
GCCTCTGCAAAAGGGAGCCCATGTAGGCCAGGGGCTGTCCAAACTCCAGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAAC
CACCCCAAGGATAATAATAGCTACACTGCTAGCTTCTCAAGTTCTTGTGAAAAACAATTTACATAATGACACAGTAGATGTGGAACACCT

>57841_57841_1_NCOR1-PIGL_NCOR1_chr17_16062074_ENST00000268712_PIGL_chr17_16203202_ENST00000225609_length(amino acids)=256AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS

--------------------------------------------------------------
>57841_57841_2_NCOR1-PIGL_NCOR1_chr17_16062074_ENST00000268712_PIGL_chr17_16203202_ENST00000395844_length(transcript)=1895nt_BP=990nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
GGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCT
GGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGTGCTCTGTGCTCACGCTTC
AGTCTGTGAATGTGCTGCGCAAGTACATCTCCCTTCTGGATCTGCCCTTGTCTCTGCTTCATACGCAGGATGTCCTCTTCGTGCTCAACA
GCAAAGAAGTGGCACAGGCCAAGAAAGCCATGTCCTGCCACCGCAGCCAGCTCCTCTGGTTCCGCCGCCTCTACATTATCTTCTCCCGGT
ACATGAGAATCAACTCACTGAGCTTCCTCTGAAGCCTTGAAGGGTTTTCAGATCCAAGGAACAAAGGGGAAAATAGACAAAGGAGTGCAG
AGGACCTGGCCTGGCACTGGCTTATTTACCTGAGCTCAAGGAGATCCCCGCTGGAGCAGCCTCTGCAAAAGGGAGCCCATGTAGGCCAGG
GGCTGTCCAAACTCCAGCTTCTTCCCCTGGGAAAAAACCCAAAGAACCAAAAACAAACCACCCCAAGGATAATAATAGCTACACTGCTAG
CTTCTCAAGTTCTTGTGAAAAACAATTTACATAATGACACAGTAGATGTGGAACACCTAGCCCAGTGCCTGGGCAGGTCCCTATTATCAT
AAATGAACATAAAAGTGCTCTAAAAACACTCCACAGATGTGACTTTTACATTGTTTCCAAAGCAGGTTCACCAAAAACACATACACAAAA
TGCAACAGTGTGTGTTGAATTGGTTCAATCATAATTCCTTTGATTTTTCTTGTATCAGAATGTGGGTCTAGGAAAAACTTGCTCTATTTA

>57841_57841_2_NCOR1-PIGL_NCOR1_chr17_16062074_ENST00000268712_PIGL_chr17_16203202_ENST00000395844_length(amino acids)=256AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS

--------------------------------------------------------------
>57841_57841_3_NCOR1-PIGL_NCOR1_chr17_16062074_ENST00000268712_PIGL_chr17_16203202_ENST00000498772_length(transcript)=1584nt_BP=990nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
GGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCT
GGTGGTGACTTTCGATGCAGGGGGAGTAAGTGGCCACAGCAATCACATTGCTCTGTATGCAGCTGTGAGGGCCCTGCACTCAGAAGGGAA
GTTACCTAAAGGTAAGGCTTGTTCCTTTTGCAAAGGGCCACAAGATACTGTCCCTCTGAGAAACTTATGAGGGGGAAATTTGCAAATCCA
CAGAGAGCTGCCCTCAGCCGAGCAGAGGCAGTGGTTGGGGAGGCCGCCACACTCTTCCTGACTCACCTCAAGGTACCTGGCAGGTTGTAT
CTACCAGCAAGTGCCTGCCTGCAGGGCCACCTCTGGATGAGTGGGGAGGCCAGGTTTGCCCCTCAACCTGTCTAGCTTTTTCACAGGGTG
GATGTTTTACACCTCTGGTATTCTTCCAGTCTGAACTCAATCCCATCCCCCAACCAATTAGGCAGGTTGTAAATGACTGCTGGGTGCTTG

>57841_57841_3_NCOR1-PIGL_NCOR1_chr17_16062074_ENST00000268712_PIGL_chr17_16203202_ENST00000498772_length(amino acids)=256AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS

--------------------------------------------------------------
>57841_57841_4_NCOR1-PIGL_NCOR1_chr17_16062074_ENST00000268712_PIGL_chr17_16203202_ENST00000581006_length(transcript)=1191nt_BP=990nt
GGAGGGAGAGGGGTTGAGTCAAGATGGCGGCCAAGGTGGCGAAGCAGCAGCCGCGGCGGCGGCGGCGGCTGGAGTGAGCGTCCGACTCGC
CGCGCCGAACGAGGTCCCGGTGTAGGGCCGCGCGCCGTGGCCGCGTCCCACTCCTCAGGCCGGGGCGCACGTCGGCTCCCACGCTTAGCC
AGCTCCCGGTGGTTTCCTAGAAACATGATTGTTTATTGGCATTGATCTCACAGTCTGGTGAGGACTTCTTTACTGATAATGTCAAGTTCA
GGTTATCCTCCCAACCAAGGAGCATTCAGCACAGAACAAAGTCGTTATCCTCCTCACTCTGTCCAGTATACATTTCCCAACACCCGCCAC
CAGCAGGAGTTCGCAGTCCCTGATTATCGTTCCTCTCATCTTGAAGTGAGTCAGGCATCACAGCTTTTGCAGCAACAGCAGCAGCAACAG
CTTCGAAGGCGACCTTCCTTGCTTTCAGAATTTCACCCAGGTTCTGACAGGCCTCAAGAAAGGAGAACTAGTTATGAACCGTTTCATCCA
GGCCCATCCCCAGTGGATCATGATTCACTGGAATCGAAGCGACCACGTCTGGAACAGGTTTCTGATTCTCATTTTCAGCGTGTCAGTGCT
GCGGTTTTGCCTTTAGTGCACCCGCTGCCAGAAGGGCTGAGGGCTTCTGCAGATGCTAAGAAGGATCCAGCATTCGGAGGCAAACATGAA
GCTCCATCCTCTCCAATTTCGGGGCAACCATGTGGAGATGATCAAAATGCTTCACCTTCAAAACTCTCAAAGGAAGAGTTAATACAGAGT
ATGGATCGTGTAGATCGAGAAATTGCAAAAGTAGAACAGCAGATCCTTAAACTGAAAAAGAAACAACAACAGCTTGAAGAAGAGGCAGCT
AAACCTCCTGAGCCTGAGAAGCCCGTGTCCCCTCCTCCTGTGGAGCAGAAACACCGCAGTATTGTCCAAATTATTTATGATGAGAATCGG
GGATTTCCCAGATGACCCAGGCATGCAGTGGGACACAGAGCACGTGGCCAGAGTCCTCCTTCAGCACATAGAAGTGAATGGCATCAATCT
GAAAGACAGAGCAAATTCCAGATTGTGAGCAGCCACCTGCATCCTCTATGCCTGAGCGGCCCAGCCATGAGAGCCAGCCGACCCCACAGA

>57841_57841_4_NCOR1-PIGL_NCOR1_chr17_16062074_ENST00000268712_PIGL_chr17_16203202_ENST00000581006_length(amino acids)=256AA_BP=
MVRTSLLIMSSSGYPPNQGAFSTEQSRYPPHSVQYTFPNTRHQQEFAVPDYRSSHLEVSQASQLLQQQQQQQLRRRPSLLSEFHPGSDRP
QERRTSYEPFHPGPSPVDHDSLESKRPRLEQVSDSHFQRVSAAVLPLVHPLPEGLRASADAKKDPAFGGKHEAPSSPISGQPCGDDQNAS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NCOR1-PIGL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461501_2440244.02441.0C1D
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191501_2440135.0915.0C1D
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451501_2440244.02338.0C1D
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646988_1816244.02441.0ETO
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319988_1816135.0915.0ETO
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545988_1816244.02338.0ETO
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-646254_312244.02441.0SIN3A/B
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-319254_312135.0915.0SIN3A/B
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-545254_312244.02338.0SIN3A/B
HgeneNCOR1chr17:16062074chr17:16203202ENST00000268712-6461_373244.02441.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395848-3191_373135.0915.0ZBTB33 and HEXIM1
HgeneNCOR1chr17:16062074chr17:16203202ENST00000395851-5451_373244.02338.0ZBTB33 and HEXIM1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NCOR1-PIGL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NCOR1-PIGL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource