FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NCOR2-DHX37 (FusionGDB2 ID:57865)

Fusion Gene Summary for NCOR2-DHX37

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR2-DHX37
Fusion gene ID: 57865
HgeneTgene
Gene symbol

NCOR2

DHX37

Gene ID

9612

57647

Gene namenuclear receptor corepressor 2DEAH-box helicase 37
SynonymsCTG26|N-CoR2|SMAP270|SMRT|SMRTE|SMRTE-tau|TNRC14|TRAC|TRAC-1|TRAC1DDX37|Dhr1|NEDBAVC
Cytomap

12q24.31

12q24.31

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressorprobable ATP-dependent RNA helicase DHX37DEAD/DEAH box helicase DDX37DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 37DEAH (Asp-Glu-Ala-His) box polypeptide 37DEAH box protein 37
Modification date2020031320200313
UniProtAcc

Q9Y618

Q8IY37

Ensembl transtripts involved in fusion geneENST00000356219, ENST00000397355, 
ENST00000404621, ENST00000405201, 
ENST00000429285, ENST00000404121, 
ENST00000544745, ENST00000308736, 
Fusion gene scores* DoF score35 X 38 X 19=252704 X 6 X 6=144
# samples 518
** MAII scorelog2(51/25270*10)=-5.63078460697328
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/144*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR2 [Title/Abstract] AND DHX37 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDHX37(125467056)-NCOR2(124922542), # samples:2
NCOR2(124950719)-DHX37(125450358), # samples:2
NCOR2(124970987)-DHX37(125470811), # samples:2
NCOR2(124846672)-DHX37(125435350), # samples:2
Anticipated loss of major functional domain due to fusion event.NCOR2-DHX37 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR2-DHX37 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR2-DHX37 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NCOR2-DHX37 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NCOR2-DHX37 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NCOR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DHX37 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0878-01ANCOR2chr12

124950719

-DHX37chr12

125450358

-
ChimerDB4OVTCGA-13-A5FT-01ANCOR2chr12

124970987

-DHX37chr12

125470811

-
ChimerDB4OVTCGA-13-A5FTNCOR2chr12

124970986

-DHX37chr12

125470811

-
ChimerDB4STADTCGA-CG-4449-01ANCOR2chr12

124846672

-DHX37chr12

125435350

-


Top

Fusion Gene ORF analysis for NCOR2-DHX37

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000356219ENST00000544745NCOR2chr12

124970987

-DHX37chr12

125470811

-
5CDS-intronENST00000356219ENST00000544745NCOR2chr12

124970986

-DHX37chr12

125470811

-
5CDS-intronENST00000397355ENST00000544745NCOR2chr12

124970987

-DHX37chr12

125470811

-
5CDS-intronENST00000397355ENST00000544745NCOR2chr12

124970986

-DHX37chr12

125470811

-
5CDS-intronENST00000404621ENST00000544745NCOR2chr12

124970987

-DHX37chr12

125470811

-
5CDS-intronENST00000404621ENST00000544745NCOR2chr12

124970986

-DHX37chr12

125470811

-
5CDS-intronENST00000405201ENST00000544745NCOR2chr12

124970987

-DHX37chr12

125470811

-
5CDS-intronENST00000405201ENST00000544745NCOR2chr12

124970986

-DHX37chr12

125470811

-
5CDS-intronENST00000429285ENST00000544745NCOR2chr12

124970987

-DHX37chr12

125470811

-
5CDS-intronENST00000429285ENST00000544745NCOR2chr12

124970986

-DHX37chr12

125470811

-
5UTR-3CDSENST00000404121ENST00000308736NCOR2chr12

124950719

-DHX37chr12

125450358

-
5UTR-3CDSENST00000404121ENST00000308736NCOR2chr12

124970987

-DHX37chr12

125470811

-
5UTR-3CDSENST00000404121ENST00000308736NCOR2chr12

124970986

-DHX37chr12

125470811

-
5UTR-3CDSENST00000404121ENST00000544745NCOR2chr12

124950719

-DHX37chr12

125450358

-
5UTR-intronENST00000404121ENST00000544745NCOR2chr12

124970987

-DHX37chr12

125470811

-
5UTR-intronENST00000404121ENST00000544745NCOR2chr12

124970986

-DHX37chr12

125470811

-
Frame-shiftENST00000356219ENST00000308736NCOR2chr12

124950719

-DHX37chr12

125450358

-
Frame-shiftENST00000356219ENST00000308736NCOR2chr12

124970987

-DHX37chr12

125470811

-
Frame-shiftENST00000356219ENST00000308736NCOR2chr12

124970986

-DHX37chr12

125470811

-
Frame-shiftENST00000356219ENST00000308736NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000356219ENST00000544745NCOR2chr12

124950719

-DHX37chr12

125450358

-
Frame-shiftENST00000356219ENST00000544745NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000397355ENST00000308736NCOR2chr12

124950719

-DHX37chr12

125450358

-
Frame-shiftENST00000397355ENST00000308736NCOR2chr12

124970987

-DHX37chr12

125470811

-
Frame-shiftENST00000397355ENST00000308736NCOR2chr12

124970986

-DHX37chr12

125470811

-
Frame-shiftENST00000397355ENST00000308736NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000397355ENST00000544745NCOR2chr12

124950719

-DHX37chr12

125450358

-
Frame-shiftENST00000397355ENST00000544745NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000404121ENST00000308736NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000404121ENST00000544745NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000404621ENST00000308736NCOR2chr12

124950719

-DHX37chr12

125450358

-
Frame-shiftENST00000404621ENST00000308736NCOR2chr12

124970987

-DHX37chr12

125470811

-
Frame-shiftENST00000404621ENST00000308736NCOR2chr12

124970986

-DHX37chr12

125470811

-
Frame-shiftENST00000404621ENST00000308736NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000404621ENST00000544745NCOR2chr12

124950719

-DHX37chr12

125450358

-
Frame-shiftENST00000404621ENST00000544745NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000405201ENST00000308736NCOR2chr12

124970987

-DHX37chr12

125470811

-
Frame-shiftENST00000405201ENST00000308736NCOR2chr12

124970986

-DHX37chr12

125470811

-
Frame-shiftENST00000405201ENST00000308736NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000405201ENST00000544745NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000429285ENST00000308736NCOR2chr12

124950719

-DHX37chr12

125450358

-
Frame-shiftENST00000429285ENST00000308736NCOR2chr12

124970987

-DHX37chr12

125470811

-
Frame-shiftENST00000429285ENST00000308736NCOR2chr12

124970986

-DHX37chr12

125470811

-
Frame-shiftENST00000429285ENST00000308736NCOR2chr12

124846672

-DHX37chr12

125435350

-
Frame-shiftENST00000429285ENST00000544745NCOR2chr12

124950719

-DHX37chr12

125450358

-
Frame-shiftENST00000429285ENST00000544745NCOR2chr12

124846672

-DHX37chr12

125435350

-
In-frameENST00000405201ENST00000308736NCOR2chr12

124950719

-DHX37chr12

125450358

-
In-frameENST00000405201ENST00000544745NCOR2chr12

124950719

-DHX37chr12

125450358

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405201NCOR2chr12124950719-ENST00000308736DHX37chr12125450358-356570612589862
ENST00000405201NCOR2chr12124950719-ENST00000544745DHX37chr12125450358-375770612643880

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405201ENST00000308736NCOR2chr12124950719-DHX37chr12125450358-0.0039874080.99601257
ENST00000405201ENST00000544745NCOR2chr12124950719-DHX37chr12125450358-0.0034110510.99658895

Top

Fusion Genomic Features for NCOR2-DHX37


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NCOR2-DHX37


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:125467056/chr12:124922542)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR2

Q9Y618

DHX37

Q8IY37

FUNCTION: Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:23911289}.FUNCTION: ATP-binding RNA helicase that plays a role in maturation of the small ribosomal subunit in ribosome biogenesis (PubMed:30582406). Required for the release of the U3 snoRNP from pre-ribosomal particles (PubMed:30582406). Plays a role in early testis development (PubMed:31287541, PubMed:31337883). Probably plays also a role in brain development (PubMed:31256877). {ECO:0000269|PubMed:30582406, ECO:0000269|PubMed:31256877, ECO:0000269|PubMed:31287541, ECO:0000269|PubMed:31337883}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648174_2152352522.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648522_5612352522.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-6481384_13892352522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-6481839_18432352522.0Compositional biasNote=Poly-Gly
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-6482476_24792352522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648494_5102352522.0Compositional biasNote=Poly-Gln
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648682_6852352522.0Compositional biasNote=Poly-Lys
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648778_8202352522.0Compositional biasNote=Pro-rich
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648995_10032352522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648427_4782352522.0DomainSANT 1
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648610_6612352522.0DomainSANT 2
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-6482136_21402352522.0MotifNote=CORNR box of ID1
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-6482339_23432352522.0MotifNote=CORNR box of ID2
TgeneDHX37chr12:124950719chr12:125450358ENST000003087361127262_4295301158.0DomainHelicase ATP-binding
TgeneDHX37chr12:124950719chr12:125450358ENST000003087361127459_7165301158.0DomainHelicase C-terminal
TgeneDHX37chr12:124950719chr12:125450358ENST000003087361127372_3755301158.0MotifNote=DEAH box
TgeneDHX37chr12:124950719chr12:125450358ENST000003087361127275_2825301158.0Nucleotide bindingATP


Top

Fusion Gene Sequence for NCOR2-DHX37


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57865_57865_1_NCOR2-DHX37_NCOR2_chr12_124950719_ENST00000405201_DHX37_chr12_125450358_ENST00000308736_length(transcript)=3565nt_BP=706nt
CATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGAT
CGCCCGGACGCACACGGACGTCGGGCTCCTGGAGTACCAGCACCACTCCCGCGACTATGCCTCCCACCTGTCGCCCGGCTCCATCATCCA
GCCCCAGCGGCGGAGGCCCTCCCTGCTGTCTGAGTTCCAGCCCGGGAATGAACGGTCCCAGGAGCTCCACCTGCGGCCAGAGTCCCACTC
ATACCTGCCCGAGCTGGGGAAGTCAGAGATGGAGTTCATTGAAAGCAAGCGCCCTCGGCTAGAGCTGCTGCCTGACCCCCTGCTGCGACC
GTCACCCCTGCTGGCCACGGGCCAGCCTGCGGGATCTGAAGACCTCACCAAGGACCGTAGCCTGACGGGCAAGCTGGAACCGGTGTCTCC
CCCCAGCCCCCCGCACACTGACCCTGAGCTGGAGCTGGTGCCGCCACGGCTGTCCAAGGAGGAGCTGATCCAGAACATGGACCGCGTGGA
CCGAGAGATCACCATGGTAGAGCAGCAGATCTCTAAGCTGAAGAAGAAGCAGCAACAGCTGGAGGAGGAGGCTGCCAAGCCGCCCGAGCC
TGAGAAGCCCGTGTCACCGCCGCCCATCGAGTCGAAGCACCGCAGCCTGGTGCAGATCATCTACGACGAGAACCGGGTGCTGCCCCAGAT
CAACTTGGATCATTACTCGGTGTTACCGGCAGGCGAAGGCGATGAGGACAGGGAGGCAGAAGTGGATGAGGAAGAGGGGGCCCTGGACTC
CGACCTCGATCTGGACCTGGGGGATGGCGGGCAAGATGGAGGTGAGCAGCCGGATGCCTCCCTCCCGCTCCACGTGCTCCCGCTGTACTC
TCTGCTGGCCCCAGAGAAGCAAGCACAGGTCTTTAAGCCTCCACCGGAGGGGACTCGGTTGTGTGTTGTGGCCACCAATGTGGCCGAGAC
GTCGCTTACCATCCCTGGCATCAAGTACGTGGTGGACTGTGGGAAGGTCAAGAAACGCTACTACGACCGCGTCACTGGCGTATCCTCCTT
CCGTGTCACCTGGGTCTCCCAGGCATCAGCTGACCAGCGAGCGGGCAGAGCAGGACGGACGGAGCCCGGCCACTGCTACAGGCTGTATTC
ATCTGCGGTTTTTGGTGACTTCGAGCAGTTTCCTCCTCCAGAAATCACCCGGAGGCCTGTTGAAGACTTAATCCTTCAAATGAAGGCGCT
CAACGTTGAAAAGGTCATCAACTTCCCCTTCCCGACGCCCCCCTCCGTGGAAGCCCTTCTTGCCGCCGAGGAGCTGTTGATCGCACTGGG
TGCCCTGCAACCGCCCCAGAAAGCAGAAAGGGTGAAGCAACTGCAGGAGAACCGGCTGAGCTGCCCCATCACTGCGCTGGGCCGGACAAT
GGCCACATTCCCCGTGGCACCCCGCTACGCTAAGATGCTGGCACTGAGCCGACAACACGGCTGCCTGCCCTATGCCATCACCATCGTGGC
CAGCATGACGGTGCGGGAGCTGTTTGAGGAGCTGGACAGACCAGCGGCCAGTGACGAGGAGCTCACCAGGCTGAAGAGCAAGCGGGCCCG
GGTGGCCCAGATGAAGAGGACCTGGGCAGGGCAGGGGGCTTCTCTGAAGCTCGGCGACCTCATGGTGCTGCTGGGCGCCGTGGGAGCCTG
TGAGTATGCCAGCTGCACACCCCAGTTTTGCGAAGCCAACGGGCTGCGGTACAAAGCCATGATGGAGATCCGGCGCCTGCGGGGCCAGCT
GACCACCGCAGTCAATGCCGTGTGCCCCGAGGCTGAGCTCTTCGTGGATCCCAAGATGCAGCCGCCCACCGAGAGCCAGGTGACCTACCT
GCGACAGATCGTGACGGCAGGCCTGGGGGACCACTTGGCCCGCAGGGTCCAGAGCGAGGAGATGCTGGAGGACAAGTGGAGGAACGCCTA
CAAGACCCCTCTCCTCGACGACCCTGTCTTCATCCACCCCAGCTCCGTCCTTTTCAAAGAGCTCCCCGAGTTTGTGGTCTACCAGGAAAT
CGTGGAGACCACTAAGATGTACATGAAAGGCGTCTCTAGCGTGGAGGTCCAGTGGATCCCGGCCCTGCTGCCCTCTTACTGCCAGTTTGA
CAAGCCCCTGGAGGAACCAGCCCCTACATACTGCCCCGAGCGGGGGCGGGTGCTGTGTCACCGGGCCAGCGTGTTCTATCGCGTGGGCTG
GCCGCTCCCCGCCATCGAGGTGGATTTTCCAGAGGGGATTGACCGCTACAAGCACTTTGCCCGGTTCCTGCTGGAAGGGCAGGTCTTCCG
CAAGCTGGCCTCATACCGGAGCTGTCTGCTGTCCAGCCCCGGCACCATGCTGAAGACGTGGGCCAGGCTGCAGCCCCGTACGGAGAGCCT
TCTGCGAGCCCTGGTTGCAGAGAAGGCTGACTGCCATGAAGCCTTGCTGGCTGCTTGGAAGAAAAACCCCAAATACCTGCTGGCTGAGTA
CTGTGAGTGGCTTCCACAGGCCATGCACCCCGATATCGAGAAAGCCTGGCCCCCCACCACTGTCCACTGACCAGAAACCTGGCTGCAGGG
CCGAGGACTGGTTTGGGGACTGGAGGGCTGGCAGCAGCCTGTCACCGTGCGACCGTGACCACCTGGCATGGGCTTCGTGGCCTGCTCTCA
GGAAGTGGGTCAAGCCCTGGGAACCCTCATCCATGAGAGCTCGATCCCGTATGAAGGGTGCTGCCGCCCGTGCCATCTGGCCCGGGGGTG
ACTTTTTGAACTGTTTATTATATGGTGGATGATGATTTCATCTCACGTGCTGGACGCTGTTCTGTTCAGTGTGCTCTTTGGACTACATTA
GTCCCCTGTGGAGCAGCAGGGCTGGAGATCTCTGCAGTCCCTTCCCCGCCCGCCCTGCCAGAAGGCCGAGGAGGCACGTGGAGGGCCTCC
TTCCTGCAATTCTTCCCTCTCCAGAGTCAGGGAGGGCTGCCCAGCCCTGGCCTCACAGCCGTCCCAGATGTTAGGTGAGCCACTGAGCTC
TGTGTTGACCTTGAGGGGCCTGGCTGGGGGCCCCCAGGCTCCATGCCTTCTTGGGAGGGTGGCCGCCAACGCCTTTCCTGTGTTATGGCA
ACAGGGAGTGGGCATCTCATCTGCCTGTGGTCAGCTCTCAGACGGCAGGGAGCGGAGCTGACGTTGGCTGTGCTTGGTCACCGCTGCCAT
GCCGCAGAGGATGCGCCTAGCTGGGCTGGGGCCACACGACTATTATGTTGGCCTTGAACGGGGACTGCAGAGCCCTCAGTTTGTCTCCCT
TGTTCCTCTGTGGCTGAGGTGGGAGGGGGAGGGTGGGGTAGGTCCCCCAGCAAGAAAGAGGGACAGGAGCACCCCAGGCAGGACCAAGGA
GTCGGGAGGCCCCTGCCTTCTGTCCTCCATGGTGAGGGCACAGATGTCTCCCCAGAGCCCAGCGCTGGCAGAATGGATTCTGCTCCTGGC

>57865_57865_1_NCOR2-DHX37_NCOR2_chr12_124950719_ENST00000405201_DHX37_chr12_125450358_ENST00000308736_length(amino acids)=862AA_BP=235
MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHS
YLPELGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDS
DLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSF
RVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALG
ALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRAR
VAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYL
RQIVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQFD
KPLEEPAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLLSSPGTMLKTWARLQPRTESL

--------------------------------------------------------------
>57865_57865_2_NCOR2-DHX37_NCOR2_chr12_124950719_ENST00000405201_DHX37_chr12_125450358_ENST00000544745_length(transcript)=3757nt_BP=706nt
CATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGAT
CGCCCGGACGCACACGGACGTCGGGCTCCTGGAGTACCAGCACCACTCCCGCGACTATGCCTCCCACCTGTCGCCCGGCTCCATCATCCA
GCCCCAGCGGCGGAGGCCCTCCCTGCTGTCTGAGTTCCAGCCCGGGAATGAACGGTCCCAGGAGCTCCACCTGCGGCCAGAGTCCCACTC
ATACCTGCCCGAGCTGGGGAAGTCAGAGATGGAGTTCATTGAAAGCAAGCGCCCTCGGCTAGAGCTGCTGCCTGACCCCCTGCTGCGACC
GTCACCCCTGCTGGCCACGGGCCAGCCTGCGGGATCTGAAGACCTCACCAAGGACCGTAGCCTGACGGGCAAGCTGGAACCGGTGTCTCC
CCCCAGCCCCCCGCACACTGACCCTGAGCTGGAGCTGGTGCCGCCACGGCTGTCCAAGGAGGAGCTGATCCAGAACATGGACCGCGTGGA
CCGAGAGATCACCATGGTAGAGCAGCAGATCTCTAAGCTGAAGAAGAAGCAGCAACAGCTGGAGGAGGAGGCTGCCAAGCCGCCCGAGCC
TGAGAAGCCCGTGTCACCGCCGCCCATCGAGTCGAAGCACCGCAGCCTGGTGCAGATCATCTACGACGAGAACCGGGTGCTGCCCCAGAT
CAACTTGGATCATTACTCGGTGTTACCGGCAGGCGAAGGCGATGAGGACAGGGAGGCAGAAGTGGATGAGGAAGAGGGGGCCCTGGACTC
CGACCTCGATCTGGACCTGGGGGATGGCGGGCAAGATGGAGGTGAGCAGCCGGATGCCTCCCTCCCGCTCCACGTGCTCCCGCTGTACTC
TCTGCTGGCCCCAGAGAAGCAAGCACAGGTCTTTAAGCCTCCACCGGAGGGGACTCGGTTGTGTGTTGTGGCCACCAATGTGGCCGAGAC
GTCGCTTACCATCCCTGGCATCAAGTACGTGGTGGACTGTGGGAAGGTCAAGAAACGCTACTACGACCGCGTCACTGGCGTATCCTCCTT
CCGTGTCACCTGGGTCTCCCAGGCATCAGCTGACCAGCGAGCGGGCAGAGCAGGACGGACGGAGCCCGGCCACTGCTACAGGCTGTATTC
ATCTGCGGTTTTTGGTGACTTCGAGCAGTTTCCTCCTCCAGAAATCACCCGGAGGCCTGTTGAAGACTTAATCCTTCAAATGAAGGCGCT
CAACGTTGAAAAGGTCATCAACTTCCCCTTCCCGACGCCCCCCTCCGTGGAAGCCCTTCTTGCCGCCGAGGAGCTGTTGATCGCACTGGG
TGCCCTGCAACCGCCCCAGAAAGCAGAAAGGGTGAAGCAACTGCAGGAGAACCGGCTGAGCTGCCCCATCACTGCGCTGGGCCGGACAAT
GGCCACATTCCCCGTGGCACCCCGCTACGCTAAGATGCTGGCACTGAGCCGACAACACGGCTGCCTGCCCTATGCCATCACCATCGTGGC
CAGCATGACGGTGCGGGAGCTGTTTGAGGAGCTGGACAGACCAGCGGCCAGTGACGAGGAGCTCACCAGGCTGAAGAGCAAGCGGGCCCG
GGTGGCCCAGATGAAGAGGACCTGGGCAGGGCAGGGGGCTTCTCTGAAGCTCGGCGACCTCATGGTGCTGCTGGGCGCCGTGGGAGCCTG
TGAGTATGCCAGCTGCACACCCCAGTTTTGCGAAGCCAACGGGCTGCGGTACAAAGCCATGATGGAGATCCGGCGCCTGCGGGGCCAGCT
GACCACCGCAGTCAATGCCGTGTGCCCCGAGGCTGAGCTCTTCGTGGATCCCAAGATGCAGCCGCCCACCGAGAGCCAGGTGACCTACCT
GCGACAGATCGTGACGGCAGGCCTGGGGGACCACTTGGCCCGCAGGGTCCAGAGCGAGGAGATGCTGGAGGACAAGTGGAGGAACGCCTA
CAAGACCCCTCTCCTCGACGACCCTGTCTTCATCCACCCCAGCTCCGTCCTTTTCAAAGAGCTCCCCGAGTTTGTGGTCTACCAGGAAAT
CGTGGAGACCACTAAGATGTACATGAAAGGCGTCTCTAGCGTGGAGGTCCAGTGGATCCCGGCCCTGCTGCCCTCTTACTGCCAGTTTGA
CAAGCCCCTGGAGGAACCAGCCCCTACATACTGCCCCGAGCGGGGGCGGGTGCTGTGTCACCGGGCCAGCGTGTTCTATCGCGTGGGCTG
GCCGCTCCCCGCCATCGAGGTGGATTTTCCAGAGGGGATTGACCGCTACAAGCACTTTGCCCGGTTCCTGCTGGAAGGGCAGGTCTTCCG
CAAGCTGGCCTCATACCGGAGCTGTCTGCTGTCCAGCCCCGGCACCATGCTGAAGACGTGGGCCAGGCTGCAGCCCCGTACGGAGAGCCT
TCTGCGAGCCCTGGTTGCAGAGAAGGCTGACTGCCATGAAGCCTTGCTGGCTGCTTGGAAGAAAAACCCCAAATGTGAGTTTGACCAGGG
CCAGGGGGTGGGAGTAGACAGGATGGGGTCACTGAGGCAGGGGCTTTGTGCTTTGTGCACGGTCAGCCCTGGCTTGGCAGAAGGATCTGG
CCCCACGGCTGCTGGCCAGCTTTTTGCCACCTGAGGAGAGTCCCTGGGCCCAGGGTCACCCTGACACTGTCCTCCTTCCCTCCCCTGCAG
ACCTGCTGGCTGAGTACTGTGAGTGGCTTCCACAGGCCATGCACCCCGATATCGAGAAAGCCTGGCCCCCCACCACTGTCCACTGACCAG
AAACCTGGCTGCAGGGCCGAGGACTGGTTTGGGGACTGGAGGGCTGGCAGCAGCCTGTCACCGTGCGACCGTGACCACCTGGCATGGGCT
TCGTGGCCTGCTCTCAGGAAGTGGGTCAAGCCCTGGGAACCCTCATCCATGAGAGCTCGATCCCGTATGAAGGGTGCTGCCGCCCGTGCC
ATCTGGCCCGGGGGTGACTTTTTGAACTGTTTATTATATGGTGGATGATGATTTCATCTCACGTGCTGGACGCTGTTCTGTTCAGTGTGC
TCTTTGGACTACATTAGTCCCCTGTGGAGCAGCAGGGCTGGAGATCTCTGCAGTCCCTTCCCCGCCCGCCCTGCCAGAAGGCCGAGGAGG
CACGTGGAGGGCCTCCTTCCTGCAATTCTTCCCTCTCCAGAGTCAGGGAGGGCTGCCCAGCCCTGGCCTCACAGCCGTCCCAGATGTTAG
GTGAGCCACTGAGCTCTGTGTTGACCTTGAGGGGCCTGGCTGGGGGCCCCCAGGCTCCATGCCTTCTTGGGAGGGTGGCCGCCAACGCCT
TTCCTGTGTTATGGCAACAGGGAGTGGGCATCTCATCTGCCTGTGGTCAGCTCTCAGACGGCAGGGAGCGGAGCTGACGTTGGCTGTGCT
TGGTCACCGCTGCCATGCCGCAGAGGATGCGCCTAGCTGGGCTGGGGCCACACGACTATTATGTTGGCCTTGAACGGGGACTGCAGAGCC
CTCAGTTTGTCTCCCTTGTTCCTCTGTGGCTGAGGTGGGAGGGGGAGGGTGGGGTAGGTCCCCCAGCAAGAAAGAGGGACAGGAGCACCC
CAGGCAGGACCAAGGAGTCGGGAGGCCCCTGCCTTCTGTCCTCCATGGTGAGGGCACAGATGTCTCCCCAGAGCCCAGCGCTGGCAGAAT

>57865_57865_2_NCOR2-DHX37_NCOR2_chr12_124950719_ENST00000405201_DHX37_chr12_125450358_ENST00000544745_length(amino acids)=880AA_BP=235
MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHS
YLPELGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRVLPQINLDHYSVLPAGEGDEDREAEVDEEEGALDS
DLDLDLGDGGQDGGEQPDASLPLHVLPLYSLLAPEKQAQVFKPPPEGTRLCVVATNVAETSLTIPGIKYVVDCGKVKKRYYDRVTGVSSF
RVTWVSQASADQRAGRAGRTEPGHCYRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALNVEKVINFPFPTPPSVEALLAAEELLIALG
ALQPPQKAERVKQLQENRLSCPITALGRTMATFPVAPRYAKMLALSRQHGCLPYAITIVASMTVRELFEELDRPAASDEELTRLKSKRAR
VAQMKRTWAGQGASLKLGDLMVLLGAVGACEYASCTPQFCEANGLRYKAMMEIRRLRGQLTTAVNAVCPEAELFVDPKMQPPTESQVTYL
RQIVTAGLGDHLARRVQSEEMLEDKWRNAYKTPLLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSSVEVQWIPALLPSYCQFD
KPLEEPAPTYCPERGRVLCHRASVFYRVGWPLPAIEVDFPEGIDRYKHFARFLLEGQVFRKLASYRSCLLSSPGTMLKTWARLQPRTESL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NCOR2-DHX37


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCOR2chr12:124950719chr12:125450358ENST00000356219-648254_312235.02522.0SIN3A/B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NCOR2-DHX37


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NCOR2-DHX37


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource