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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCOR2-NOC4L (FusionGDB2 ID:57876)

Fusion Gene Summary for NCOR2-NOC4L

check button Fusion gene summary
Fusion gene informationFusion gene name: NCOR2-NOC4L
Fusion gene ID: 57876
HgeneTgene
Gene symbol

NCOR2

NOC4L

Gene ID

9612

79050

Gene namenuclear receptor corepressor 2nucleolar complex associated 4 homolog
SynonymsCTG26|N-CoR2|SMAP270|SMRT|SMRTE|SMRTE-tau|TNRC14|TRAC|TRAC-1|TRAC1NET49|NOC4|UTP19
Cytomap

12q24.31

12q24.33

Type of geneprotein-codingprotein-coding
Descriptionnuclear receptor corepressor 2CTG repeat protein 26T3 receptor-associating factorsilencing mediator for retinoid and thyroid hormone receptorsthyroid-, retinoic-acid-receptor-associated corepressornucleolar complex protein 4 homologNOC4 protein homologNOC4-like proteinnucleolar complex-associated protein 4-like protein
Modification date2020031320200313
UniProtAcc

Q9Y618

Q9BVI4

Ensembl transtripts involved in fusion geneENST00000356219, ENST00000397355, 
ENST00000404121, ENST00000404621, 
ENST00000405201, ENST00000429285, 
ENST00000538784, ENST00000535343, 
ENST00000330579, 
Fusion gene scores* DoF score35 X 38 X 19=2527036 X 4 X 20=2880
# samples 5141
** MAII scorelog2(51/25270*10)=-5.63078460697328
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(41/2880*10)=-2.81237299682423
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCOR2 [Title/Abstract] AND NOC4L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCOR2(124882664)-NOC4L(132635525), # samples:1
Anticipated loss of major functional domain due to fusion event.NCOR2-NOC4L seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
NCOR2-NOC4L seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
NCOR2-NOC4L seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NCOR2-NOC4L seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NCOR2-NOC4L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NCOR2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NOC4L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A16RNCOR2chr12

124882664

-NOC4Lchr12

132635525

+


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Fusion Gene ORF analysis for NCOR2-NOC4L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000356219ENST00000538784NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-5UTRENST00000397355ENST00000538784NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-5UTRENST00000404121ENST00000538784NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-5UTRENST00000404621ENST00000538784NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-5UTRENST00000405201ENST00000538784NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-5UTRENST00000429285ENST00000538784NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-intronENST00000356219ENST00000535343NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-intronENST00000397355ENST00000535343NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-intronENST00000404121ENST00000535343NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-intronENST00000404621ENST00000535343NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-intronENST00000405201ENST00000535343NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
5CDS-intronENST00000429285ENST00000535343NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
Frame-shiftENST00000356219ENST00000330579NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
Frame-shiftENST00000397355ENST00000330579NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
Frame-shiftENST00000404121ENST00000330579NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
Frame-shiftENST00000404621ENST00000330579NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
Frame-shiftENST00000429285ENST00000330579NCOR2chr12

124882664

-NOC4Lchr12

132635525

+
In-frameENST00000405201ENST00000330579NCOR2chr12

124882664

-NOC4Lchr12

132635525

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000405201NCOR2chr12124882664-ENST00000330579NOC4Lchr12132635525+2567187712526841

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405201ENST00000330579NCOR2chr12124882664-NOC4Lchr12132635525+0.031162080.968838

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Fusion Genomic Features for NCOR2-NOC4L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCOR2chr12124882664-NOC4Lchr12132635525+0.0041220620.995878
NCOR2chr12124882664-NOC4Lchr12132635525+0.0041220620.995878

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCOR2-NOC4L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:124882664/chr12:132635525)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCOR2

Q9Y618

NOC4L

Q9BVI4

FUNCTION: Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:23911289}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748174_2156252522.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748522_5616252522.0Coiled coilOntology_term=ECO:0000255
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748494_5106252522.0Compositional biasNote=Poly-Gln
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748427_4786252522.0DomainSANT 1
TgeneNOC4Lchr12:124882664chr12:132635525ENST00000330579815347_367300517.0TransmembraneHelical
TgeneNOC4Lchr12:124882664chr12:132635525ENST00000330579815375_395300517.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-17481384_13896252522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-17481839_18436252522.0Compositional biasNote=Poly-Gly
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-17482476_24796252522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748682_6856252522.0Compositional biasNote=Poly-Lys
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748778_8206252522.0Compositional biasNote=Pro-rich
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748995_10036252522.0Compositional biasNote=Poly-Pro
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748610_6616252522.0DomainSANT 2
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-17482136_21406252522.0MotifNote=CORNR box of ID1
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-17482339_23436252522.0MotifNote=CORNR box of ID2
TgeneNOC4Lchr12:124882664chr12:132635525ENST00000330579815297_317300517.0TransmembraneHelical


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Fusion Gene Sequence for NCOR2-NOC4L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57876_57876_1_NCOR2-NOC4L_NCOR2_chr12_124882664_ENST00000405201_NOC4L_chr12_132635525_ENST00000330579_length(transcript)=2567nt_BP=1877nt
CATGTCGGGATCCACACAGCCTGTGGCACAGACGTGGAGGGCCACTGAGCCCCGCTACCCGCCCCACAGCCTTTCCTACCCAGTGCAGAT
CGCCCGGACGCACACGGACGTCGGGCTCCTGGAGTACCAGCACCACTCCCGCGACTATGCCTCCCACCTGTCGCCCGGCTCCATCATCCA
GCCCCAGCGGCGGAGGCCCTCCCTGCTGTCTGAGTTCCAGCCCGGGAATGAACGGTCCCAGGAGCTCCACCTGCGGCCAGAGTCCCACTC
ATACCTGCCCGAGCTGGGGAAGTCAGAGATGGAGTTCATTGAAAGCAAGCGCCCTCGGCTAGAGCTGCTGCCTGACCCCCTGCTGCGACC
GTCACCCCTGCTGGCCACGGGCCAGCCTGCGGGATCTGAAGACCTCACCAAGGACCGTAGCCTGACGGGCAAGCTGGAACCGGTGTCTCC
CCCCAGCCCCCCGCACACTGACCCTGAGCTGGAGCTGGTGCCGCCACGGCTGTCCAAGGAGGAGCTGATCCAGAACATGGACCGCGTGGA
CCGAGAGATCACCATGGTAGAGCAGCAGATCTCTAAGCTGAAGAAGAAGCAGCAACAGCTGGAGGAGGAGGCTGCCAAGCCGCCCGAGCC
TGAGAAGCCCGTGTCACCGCCGCCCATCGAGTCGAAGCACCGCAGCCTGGTGCAGATCATCTACGACGAGAACCGGAAGAAGGCTGAAGC
TGCACATCGGATTCTGGAAGGCCTGGGGCCCCAGGTGGAGCTGCCGCTGTACAACCAGCCCTCCGACACCCGGCAGTATCATGAGAACAT
CAAAATAAACCAGGCGATGCGGAAGAAGCTAATCTTGTACTTCAAGAGGAGGAATCACGCTCGGAAACAATGGGAGCAGAAGTTCTGCCA
GCGCTATGACCAGCTCATGGAGGCCTGGGAGAAGAAGGTGGAGCGCATCGAGAACAACCCCCGGCGGCGGGCCAAGGAGAGCAAGGTGCG
CGAGTACTACGAGAAGCAGTTCCCTGAGATCCGCAAGCAGCGCGAGCTGCAGGAGCGCATGCAGAGCAGGGTGGGCCAGCGGGGCAGTGG
GCTGTCCATGTCGGCCGCCCGCAGCGAGCACGAGGTGTCAGAGATCATCGATGGCCTCTCAGAGCAGGAGAACCTGGAGAAGCAGATGCG
CCAGCTGGCCGTGATCCCGCCCATGCTGTACGACGCTGACCAGCAGCGCATCAAGTTCATCAACATGAACGGGCTTATGGCCGACCCCAT
GAAGGTGTACAAAGACCGCCAGGTCATGAACATGTGGAGTGAGCAGGAGAAGGAGACCTTCCGGGAGAAGTTCATGCAGCATCCCAAGAA
CTTTGGCCTGATCGCATCATTCCTGGAGAGGAAGACAGTGGCTGAGTGCGTCCTCTATTACTACCTGACTAAGAAGAATGAGAACTATAA
GAGCCTGGTGAGACGGAGCTATCGGCGCCGCGGCAAGAGCCAGCAGCAGCAACAACAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCAGCA
GCCCATGCCCCGCAGCAGCCAGGAGGAGAAAGATGAGAAGGAGAAGGAAAAGGAGGCGGAGAAGGAGGAGGAGAAGCCGGAGGTGGAGAA
CGACAAGGAAGACCTCCTCAAGGAGAAGACAGACGACACCTCAGGGGAGGACAACGACGAGAAGGAGGCTGTGGCCTCCAAAGGCCGCAA
AACTGCCAACAGCCAGGGAAGACGCAAAGGCCGCATCACCCGCTCAATGGCTAATGAGGCCAACAGCGAGGAGGCCATCACCCCCCAGCA
GAGCGCCGAGCTGGCCTCCATGGAGCTGAATGAGAGTTCTCGCTGGACAGAAGAAGAAATGGAAACAGCCAAGAAAGGGGGGGCCCTCAG
CCTCTTGGCCTTGAACGGGCTGTTCATCTTGATTCACAAACACAACCTGGAGTACCCTGACTTCTACCGGAAGCTCTACGGCCTCTTGGA
CCCCTCTGTCTTTCACGTCAAGTACCGCGCCCGCTTCTTCCACCTGGCTGACCTCTTCCTGTCCTCCTCCCACCTCCCCGCCTACCTGGT
GGCCGCCTTCGCCAAGCGGCTGGCCCGCCTGGCCCTGACGGCTCCCCCTGAGGCCCTGCTCATGGTCCTGCCTTTCATCTGTAACCTGCT
GCGCCGGCACCCTGCCTGCCGGGTCCTCGTGCACCGTCCACACGGCCCTGAGTTGGACGCCGACCCCTACGACCCTGGAGAGGAGGACCC
AGCCCAGAGCCGGGCCTTGGAGAGCTCCCTGTGGGAGCTTCAGGCCCTCCAGCGCCACTACCACCCTGAGGTGTCCAAAGCCGCCAGCGT
CATCAACCAGGCCCTGTCCATGCCTGAGGTCAGCATCGCGCCACTGCTGGAGCTCACGGCCTACGAGATCTTTGAGCGGGACCTGAAGAA
GAAGGGGCCCGAGCCGGTGCCACTGGAGTTTATCCCAGCCCAGGGCCTGCTGGGACGGCCGGGTGAACTCTGTGCCCAGCACTTCACGCT

>57876_57876_1_NCOR2-NOC4L_NCOR2_chr12_124882664_ENST00000405201_NOC4L_chr12_132635525_ENST00000330579_length(amino acids)=841AA_BP=625
MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHS
YLPELGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVD
REITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENI
KINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSG
LSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKN
FGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVEN
DKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGGALS
LLALNGLFILIHKHNLEYPDFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPFICNLL
RRHPACRVLVHRPHGPELDADPYDPGEEDPAQSRALESSLWELQALQRHYHPEVSKAASVINQALSMPEVSIAPLLELTAYEIFERDLKK

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Fusion Gene PPI Analysis for NCOR2-NOC4L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneNCOR2chr12:124882664chr12:132635525ENST00000356219-1748254_312625.33333333333342522.0SIN3A/B


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCOR2-NOC4L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCOR2-NOC4L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource