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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCS1-AP3D1 (FusionGDB2 ID:57894)

Fusion Gene Summary for NCS1-AP3D1

check button Fusion gene summary
Fusion gene informationFusion gene name: NCS1-AP3D1
Fusion gene ID: 57894
HgeneTgene
Gene symbol

NCS1

AP3D1

Gene ID

23413

8943

Gene nameneuronal calcium sensor 1adaptor related protein complex 3 subunit delta 1
SynonymsFLUP|FREQADTD|HPS10|hBLVR
Cytomap

9q34.11

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionneuronal calcium sensor 1frequenin homologfrequenin-like proteinfrequenin-like ubiquitous proteinAP-3 complex subunit delta-1AP-3 complex delta subunit, partial CDSadapter-related protein complex 3 subunit delta-1adaptor related protein complex 3 delta 1 subunitdelta adaptinsubunit of putative vesicle coat adaptor complex AP-3
Modification date2020031320200313
UniProtAcc

P62166

O14617

Ensembl transtripts involved in fusion geneENST00000493042, ENST00000372398, 
ENST00000458469, 		ENST00000345016, 
ENST00000350812, ENST00000355272, 
ENST00000356926, ENST00000590683, 
Fusion gene scores* DoF score6 X 5 X 6=18012 X 12 X 8=1152
# samples 613
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/1152*10)=-3.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NCS1 [Title/Abstract] AND AP3D1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCS1(132963261)-AP3D1(2102267), # samples:1
Anticipated loss of major functional domain due to fusion event.NCS1-AP3D1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NCS1-AP3D1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NCS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AP3D1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04Q-01ANCS1chr9

132963261

+AP3D1chr19

2102267

-


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Fusion Gene ORF analysis for NCS1-AP3D1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000493042ENST00000345016NCS1chr9

132963261

+AP3D1chr19

2102267

-
3UTR-3CDSENST00000493042ENST00000350812NCS1chr9

132963261

+AP3D1chr19

2102267

-
3UTR-3CDSENST00000493042ENST00000355272NCS1chr9

132963261

+AP3D1chr19

2102267

-
3UTR-3CDSENST00000493042ENST00000356926NCS1chr9

132963261

+AP3D1chr19

2102267

-
3UTR-intronENST00000493042ENST00000590683NCS1chr9

132963261

+AP3D1chr19

2102267

-
5CDS-intronENST00000372398ENST00000590683NCS1chr9

132963261

+AP3D1chr19

2102267

-
5CDS-intronENST00000458469ENST00000590683NCS1chr9

132963261

+AP3D1chr19

2102267

-
Frame-shiftENST00000372398ENST00000345016NCS1chr9

132963261

+AP3D1chr19

2102267

-
Frame-shiftENST00000372398ENST00000350812NCS1chr9

132963261

+AP3D1chr19

2102267

-
Frame-shiftENST00000372398ENST00000356926NCS1chr9

132963261

+AP3D1chr19

2102267

-
Frame-shiftENST00000458469ENST00000345016NCS1chr9

132963261

+AP3D1chr19

2102267

-
Frame-shiftENST00000458469ENST00000350812NCS1chr9

132963261

+AP3D1chr19

2102267

-
Frame-shiftENST00000458469ENST00000356926NCS1chr9

132963261

+AP3D1chr19

2102267

-
In-frameENST00000372398ENST00000355272NCS1chr9

132963261

+AP3D1chr19

2102267

-
In-frameENST00000458469ENST00000355272NCS1chr9

132963261

+AP3D1chr19

2102267

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372398NCS1chr9132963261+ENST00000355272AP3D1chr192102267-14501751216455253
ENST00000458469NCS1chr9132963261+ENST00000355272AP3D1chr192102267-1319445001108202

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372398ENST00000355272NCS1chr9132963261+AP3D1chr192102267-0.72479630.27520368
ENST00000458469ENST00000355272NCS1chr9132963261+AP3D1chr192102267-0.94072760.059272468

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Fusion Genomic Features for NCS1-AP3D1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NCS1-AP3D1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:132963261/chr19:2102267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCS1

P62166

AP3D1

O14617

FUNCTION: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity (By similarity). Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity). May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity). {ECO:0000250}.FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (By similarity). {ECO:0000250|UniProtKB:O54774, ECO:0000269|PubMed:26744459}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCS1chr9:132963261chr19:2102267ENST00000372398+28109_120291579.3333333333333Calcium binding2
HgeneNCS1chr9:132963261chr19:2102267ENST00000372398+28157_168291579.3333333333333Calcium binding3
HgeneNCS1chr9:132963261chr19:2102267ENST00000372398+2873_84291579.3333333333333Calcium binding1
HgeneNCS1chr9:132963261chr19:2102267ENST00000458469+28109_120111605.0Calcium binding2
HgeneNCS1chr9:132963261chr19:2102267ENST00000458469+28157_168111605.0Calcium binding3
HgeneNCS1chr9:132963261chr19:2102267ENST00000458469+2873_84111605.0Calcium binding1
HgeneNCS1chr9:132963261chr19:2102267ENST00000372398+28144_179291579.3333333333333DomainEF-hand 4
HgeneNCS1chr9:132963261chr19:2102267ENST00000372398+2824_59291579.3333333333333DomainEF-hand 1
HgeneNCS1chr9:132963261chr19:2102267ENST00000372398+2860_95291579.3333333333333DomainEF-hand 2
HgeneNCS1chr9:132963261chr19:2102267ENST00000372398+2896_131291579.3333333333333DomainEF-hand 3
HgeneNCS1chr9:132963261chr19:2102267ENST00000458469+28144_179111605.0DomainEF-hand 4
HgeneNCS1chr9:132963261chr19:2102267ENST00000458469+2824_59111605.0DomainEF-hand 1
HgeneNCS1chr9:132963261chr19:2102267ENST00000458469+2860_95111605.0DomainEF-hand 2
HgeneNCS1chr9:132963261chr19:2102267ENST00000458469+2896_131111605.0DomainEF-hand 3
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830659_67911221154.0Coiled coilOntology_term=ECO:0000255
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830725_75611221154.0Coiled coilOntology_term=ECO:0000255
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830845_86911221154.0Coiled coilOntology_term=ECO:0000255
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032659_67911841216.0Coiled coilOntology_term=ECO:0000255
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032725_75611841216.0Coiled coilOntology_term=ECO:0000255
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032845_86911841216.0Coiled coilOntology_term=ECO:0000255
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830828_89311221154.0Compositional biasNote=Lys-rich
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032828_89311841216.0Compositional biasNote=Lys-rich
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830142_17911221154.0RepeatNote=HEAT 3
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830180_21611221154.0RepeatNote=HEAT 4
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830254_29211221154.0RepeatNote=HEAT 5
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830299_33611221154.0RepeatNote=HEAT 6
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830338_37311221154.0RepeatNote=HEAT 7
TgeneAP3D1chr9:132963261chr19:2102267ENST00000345016283034_7111221154.0RepeatNote=HEAT 1
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830375_40911221154.0RepeatNote=HEAT 8
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830431_46811221154.0RepeatNote=HEAT 9
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830497_53511221154.0RepeatNote=HEAT 10
TgeneAP3D1chr9:132963261chr19:2102267ENST000003450162830548_58511221154.0RepeatNote=HEAT 11
TgeneAP3D1chr9:132963261chr19:2102267ENST00000345016283077_11411221154.0RepeatNote=HEAT 2
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032142_17911841216.0RepeatNote=HEAT 3
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032180_21611841216.0RepeatNote=HEAT 4
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032254_29211841216.0RepeatNote=HEAT 5
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032299_33611841216.0RepeatNote=HEAT 6
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032338_37311841216.0RepeatNote=HEAT 7
TgeneAP3D1chr9:132963261chr19:2102267ENST00000355272303234_7111841216.0RepeatNote=HEAT 1
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032375_40911841216.0RepeatNote=HEAT 8
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032431_46811841216.0RepeatNote=HEAT 9
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032497_53511841216.0RepeatNote=HEAT 10
TgeneAP3D1chr9:132963261chr19:2102267ENST000003552723032548_58511841216.0RepeatNote=HEAT 11
TgeneAP3D1chr9:132963261chr19:2102267ENST00000355272303277_11411841216.0RepeatNote=HEAT 2


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Fusion Gene Sequence for NCS1-AP3D1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57894_57894_1_NCS1-AP3D1_NCS1_chr9_132963261_ENST00000372398_AP3D1_chr19_2102267_ENST00000355272_length(transcript)=1450nt_BP=175nt
CCGGCCCGGCCCGCCCGGCCCAGCCGCTCCTGCTGGGCGCCCCAACCGGGTCCGGCCCGGGGGGGCGGGGGCCGCGGCCGCCGAGGATGG
GGAAATCCAACAGCAAGTTGAAGCCCGAAGTTGTGGAGGAGCTGACCAGGAAGACCTACTTTACCGAGAAGGAGGTCCAGCAGTGGGTGA
GAACTCTGTCTCAGTCGACGGGAAGTGCAGTGACTCCACGCTACTGAGCAACTTGTTAGAAGAGATGAAGGCGACGCTGGCCAAGTGTTG
AGAGCTGCCTGCGAGCCCCGCACCACCCCGCGGAGCACGTACCCAGGGACCGCAGCCCTGACGTGTCTCGCCTCTCCTCAGTCGTGTGTA
CTGTACCCAAGCCTGAGTGTTAATTTAACTCTATGTTGTCCGCCGTGTAGACATCCGAGGTCATTTGTTGCGTTGAATTATCTGACCATC
CTTTTTTACTGTGACTCTTCCCATTCTCTTTGGCAAGAAGTCCCCTTCTCGCCCCCAAACCAGCAAGGGACTCCCCCACCTGGGTCTGTG
CCCTGCCCCGCGCTGGGGGCCGAGTCCTTGAATGTGGCTTCAGGGGCTCCTGTCCTGGGCCAGGGCCTGATGGGCACCACGTGAGGGGCA
CTTGGTGGACAGGGCGGGGCTGACGTGGCCTCCTCTGGGGTCGCCTGCTTTTGACCCAAAGGTCCTGACGGTTGCGTCCGGGGGAGGGGA
AGGAAGGGCCGCTGTCGCCAAGGTTTTCTCTCCCAGAACCCACAGTGGGAAAGCGGTCTTGCCAGGCGTTGTCCATTGTCAGTGTGCTCG
TGGGCTGGTGACTGGGTCTTGGGATCCCAGGCCACGCGCCAGCCAGGCTGTGGGCAGGGCGGGGCCAGGGACGCCAAAGAGAGGTTGCAG
TCAGAACCGTGGACGGGGTGGGTTGAGGCCTCTCTGCCACCCGTCTTCCTGGTCAGCAGAAGTGCATCTCGGCTTGGGTTTGGGGTGGTC
CGCATCCCCTGCTTGCCACTATGCGCACCAAGGTTTCCCCACATCCTTCCCAGCACCCTTAGGAAGGCCCAGGCAGGGCCTGGAAGCAGC
GGACCTGGGCTGTTCTGTGTTGAAGGAGTGTGCCCAGTGCCCTTGGGCAGGACCTGTGAGAGCCACCTCACAGGCAGAGCCCCCACCAGG
CAGGGCAAGGAGACTCCGCTCACTCCCCACGGCCAGCGTGGGCACAGGACTGACCCTTCTTCAGAGATAATGACATTTTATCTTCTCCTT
TTGATGAAAACTGTCACTTTAGCATGTAATCCATTACAGAATCCCATGCAGTGATTCCAGGATTTGAAATTGTATGATGTGTTACATAAG
AATTTATTTGCTATCGACATTCCCGTATAAAGAGAGAGACATATCACGCTGCTGTCATGATTTTGTGTCAAGATGATCCAATAAAGTTGT

>57894_57894_1_NCS1-AP3D1_NCS1_chr9_132963261_ENST00000372398_AP3D1_chr19_2102267_ENST00000355272_length(amino acids)=253AA_BP=
MCPRWPWGVSGVSLPCLVGALPVRWLSQVLPKGTGHTPSTQNSPGPLLPGPAWAFLRVLGRMWGNLGAHSGKQGMRTTPNPSRDALLLTR
KTGGREASTHPVHGSDCNLSLASLAPPCPQPGWRVAWDPKTQSPAHEHTDNGQRLARPLSHCGFWERKPWRQRPFLPLPRTQPSGPLGQK

--------------------------------------------------------------
>57894_57894_2_NCS1-AP3D1_NCS1_chr9_132963261_ENST00000458469_AP3D1_chr19_2102267_ENST00000355272_length(transcript)=1319nt_BP=44nt
GATTGAGAGATGGCAACGATTACCGAGAAGGAGGTCCAGCAGTGGGTGAGAACTCTGTCTCAGTCGACGGGAAGTGCAGTGACTCCACGC
TACTGAGCAACTTGTTAGAAGAGATGAAGGCGACGCTGGCCAAGTGTTGAGAGCTGCCTGCGAGCCCCGCACCACCCCGCGGAGCACGTA
CCCAGGGACCGCAGCCCTGACGTGTCTCGCCTCTCCTCAGTCGTGTGTACTGTACCCAAGCCTGAGTGTTAATTTAACTCTATGTTGTCC
GCCGTGTAGACATCCGAGGTCATTTGTTGCGTTGAATTATCTGACCATCCTTTTTTACTGTGACTCTTCCCATTCTCTTTGGCAAGAAGT
CCCCTTCTCGCCCCCAAACCAGCAAGGGACTCCCCCACCTGGGTCTGTGCCCTGCCCCGCGCTGGGGGCCGAGTCCTTGAATGTGGCTTC
AGGGGCTCCTGTCCTGGGCCAGGGCCTGATGGGCACCACGTGAGGGGCACTTGGTGGACAGGGCGGGGCTGACGTGGCCTCCTCTGGGGT
CGCCTGCTTTTGACCCAAAGGTCCTGACGGTTGCGTCCGGGGGAGGGGAAGGAAGGGCCGCTGTCGCCAAGGTTTTCTCTCCCAGAACCC
ACAGTGGGAAAGCGGTCTTGCCAGGCGTTGTCCATTGTCAGTGTGCTCGTGGGCTGGTGACTGGGTCTTGGGATCCCAGGCCACGCGCCA
GCCAGGCTGTGGGCAGGGCGGGGCCAGGGACGCCAAAGAGAGGTTGCAGTCAGAACCGTGGACGGGGTGGGTTGAGGCCTCTCTGCCACC
CGTCTTCCTGGTCAGCAGAAGTGCATCTCGGCTTGGGTTTGGGGTGGTCCGCATCCCCTGCTTGCCACTATGCGCACCAAGGTTTCCCCA
CATCCTTCCCAGCACCCTTAGGAAGGCCCAGGCAGGGCCTGGAAGCAGCGGACCTGGGCTGTTCTGTGTTGAAGGAGTGTGCCCAGTGCC
CTTGGGCAGGACCTGTGAGAGCCACCTCACAGGCAGAGCCCCCACCAGGCAGGGCAAGGAGACTCCGCTCACTCCCCACGGCCAGCGTGG
GCACAGGACTGACCCTTCTTCAGAGATAATGACATTTTATCTTCTCCTTTTGATGAAAACTGTCACTTTAGCATGTAATCCATTACAGAA
TCCCATGCAGTGATTCCAGGATTTGAAATTGTATGATGTGTTACATAAGAATTTATTTGCTATCGACATTCCCGTATAAAGAGAGAGACA

>57894_57894_2_NCS1-AP3D1_NCS1_chr9_132963261_ENST00000458469_AP3D1_chr19_2102267_ENST00000355272_length(amino acids)=202AA_BP=
MVDRAGLTWPPLGSPAFDPKVLTVASGGGEGRAAVAKVFSPRTHSGKAVLPGVVHCQCARGLVTGSWDPRPRASQAVGRAGPGTPKRGCS
QNRGRGGLRPLCHPSSWSAEVHLGLGLGWSASPACHYAHQGFPTSFPAPLGRPRQGLEAADLGCSVLKECAQCPWAGPVRATSQAEPPPG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NCS1-AP3D1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneNCS1chr9:132963261chr19:2102267ENST00000372398+28174_19029.6666666666666681579.3333333333333IL1RAPL1
HgeneNCS1chr9:132963261chr19:2102267ENST00000458469+28174_19011.6666666666666661605.0IL1RAPL1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCS1-AP3D1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCS1-AP3D1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource