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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NCSTN-ATP1A4 (FusionGDB2 ID:57901)

Fusion Gene Summary for NCSTN-ATP1A4

check button Fusion gene summary
Fusion gene informationFusion gene name: NCSTN-ATP1A4
Fusion gene ID: 57901
HgeneTgene
Gene symbol

NCSTN

ATP1A4

Gene ID

23385

480

Gene namenicastrinATPase Na+/K+ transporting subunit alpha 4
SynonymsATAG1874ATP1A1|ATP1AL2
Cytomap

1q23.2

1q23.2

Type of geneprotein-codingprotein-coding
Descriptionnicastrinanterior pharynx-defective 2sodium/potassium-transporting ATPase subunit alpha-4ATPase, Na+/K+ transporting, alpha 4 polypeptideATPase, Na+/K+ transporting, alpha polypeptide-like 2Na(+)/K(+) ATPase alpha-4 subunitNa+/K+ ATPase 4Na+/K+ ATPase, alpha-D polypeptideNa,K-ATPase su
Modification date2020032720200313
UniProtAcc

Q92542

.
Ensembl transtripts involved in fusion geneENST00000294785, ENST00000368063, 
ENST00000392212, ENST00000535857, 
ENST00000368065, ENST00000459963, 
ENST00000418334, ENST00000470705, 
ENST00000368081, 
Fusion gene scores* DoF score6 X 7 X 4=1682 X 2 X 2=8
# samples 72
** MAII scorelog2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: NCSTN [Title/Abstract] AND ATP1A4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNCSTN(160314616)-ATP1A4(160145882), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNCSTN

GO:0006509

membrane protein ectodomain proteolysis

15274632

HgeneNCSTN

GO:0016485

protein processing

15274632

HgeneNCSTN

GO:0042982

amyloid precursor protein metabolic process

25043039|26280335

HgeneNCSTN

GO:0043085

positive regulation of catalytic activity

15274632

TgeneATP1A4

GO:0030317

flagellated sperm motility

12112599

TgeneATP1A4

GO:0030641

regulation of cellular pH

12112599


check buttonFusion gene breakpoints across NCSTN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP1A4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1FD-01ANCSTNchr1

160314616

-ATP1A4chr1

160145882

+
ChimerDB4BRCATCGA-BH-A1FD-01ANCSTNchr1

160314616

+ATP1A4chr1

160145882

+


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Fusion Gene ORF analysis for NCSTN-ATP1A4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000294785ENST00000418334NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
5CDS-3UTRENST00000368063ENST00000418334NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
5CDS-3UTRENST00000392212ENST00000418334NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
5CDS-3UTRENST00000535857ENST00000418334NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
5CDS-intronENST00000294785ENST00000470705NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
5CDS-intronENST00000368063ENST00000470705NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
5CDS-intronENST00000392212ENST00000470705NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
5CDS-intronENST00000535857ENST00000470705NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
In-frameENST00000294785ENST00000368081NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
In-frameENST00000368063ENST00000368081NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
In-frameENST00000392212ENST00000368081NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
In-frameENST00000535857ENST00000368081NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
intron-3CDSENST00000368065ENST00000368081NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
intron-3CDSENST00000459963ENST00000368081NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
intron-3UTRENST00000368065ENST00000418334NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
intron-3UTRENST00000459963ENST00000418334NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
intron-intronENST00000368065ENST00000470705NCSTNchr1

160314616

+ATP1A4chr1

160145882

+
intron-intronENST00000459963ENST00000470705NCSTNchr1

160314616

+ATP1A4chr1

160145882

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294785NCSTNchr1160314616+ENST00000368081ATP1A4chr1160145882+13723151251093322
ENST00000368063NCSTNchr1160314616+ENST00000368081ATP1A4chr1160145882+14674102801188302
ENST00000535857NCSTNchr1160314616+ENST00000368081ATP1A4chr1160145882+125820111979322
ENST00000392212NCSTNchr1160314616+ENST00000368081ATP1A4chr1160145882+11871300908302

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294785ENST00000368081NCSTNchr1160314616+ATP1A4chr1160145882+0.0052961520.9947038
ENST00000368063ENST00000368081NCSTNchr1160314616+ATP1A4chr1160145882+0.0042045270.9957955
ENST00000535857ENST00000368081NCSTNchr1160314616+ATP1A4chr1160145882+0.0050023060.99499774
ENST00000392212ENST00000368081NCSTNchr1160314616+ATP1A4chr1160145882+0.0042873670.99571264

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Fusion Genomic Features for NCSTN-ATP1A4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NCSTNchr1160314616+ATP1A4chr1160145881+2.32E-050.99997675
NCSTNchr1160314616+ATP1A4chr1160145881+2.32E-050.99997675

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NCSTN-ATP1A4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:160314616/chr1:160145882)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NCSTN

Q92542

.
FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:10993067, PubMed:12679784, PubMed:25043039, PubMed:26280335, PubMed:30598546, PubMed:30630874). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. {ECO:0000269|PubMed:10993067, ECO:0000269|PubMed:12679784, ECO:0000269|PubMed:25043039, ECO:0000269|PubMed:26280335, ECO:0000269|PubMed:30598546, ECO:0000269|PubMed:30630874}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP1A4chr1:160314616chr1:160145882ENST0000036808114221013_10297701030.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422799_8087701030.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422830_8497701030.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422873_9247701030.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422945_9577701030.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422977_9917701030.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST00000470705051013_10290166.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505117_1390166.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505161_2960166.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST00000470705051_950166.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505317_3280166.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505347_7780166.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505799_8080166.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505830_8490166.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505873_9240166.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505945_9570166.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505977_9910166.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422779_7987701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422809_8297701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422850_8727701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422925_9447701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422958_9767701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422992_10127701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505140_1600166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505297_3160166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505329_3460166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505779_7980166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505809_8290166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505850_8720166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505925_9440166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505958_9760166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000004707050596_1160166.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST0000047070505992_10120166.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNCSTNchr1:160314616chr1:160145882ENST00000294785+21734_66963710.0Topological domainExtracellular
HgeneNCSTNchr1:160314616chr1:160145882ENST00000294785+217691_70963710.0Topological domainCytoplasmic
HgeneNCSTNchr1:160314616chr1:160145882ENST00000368063+31834_66943690.0Topological domainExtracellular
HgeneNCSTNchr1:160314616chr1:160145882ENST00000368063+318691_70943690.0Topological domainCytoplasmic
HgeneNCSTNchr1:160314616chr1:160145882ENST00000392212+21734_66943690.0Topological domainExtracellular
HgeneNCSTNchr1:160314616chr1:160145882ENST00000392212+217691_70943690.0Topological domainCytoplasmic
HgeneNCSTNchr1:160314616chr1:160145882ENST00000294785+217670_69063710.0TransmembraneHelical
HgeneNCSTNchr1:160314616chr1:160145882ENST00000368063+318670_69043690.0TransmembraneHelical
HgeneNCSTNchr1:160314616chr1:160145882ENST00000392212+217670_69043690.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422117_1397701030.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422161_2967701030.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST0000036808114221_957701030.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422317_3287701030.0Topological domainExtracellular
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422347_7787701030.0Topological domainCytoplasmic
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422140_1607701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422297_3167701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST000003680811422329_3467701030.0TransmembraneHelical
TgeneATP1A4chr1:160314616chr1:160145882ENST00000368081142296_1167701030.0TransmembraneHelical


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Fusion Gene Sequence for NCSTN-ATP1A4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>57901_57901_1_NCSTN-ATP1A4_NCSTN_chr1_160314616_ENST00000294785_ATP1A4_chr1_160145882_ENST00000368081_length(transcript)=1372nt_BP=315nt
GCGCCTGGAAACACGAACTTCCGGTCTCTTAGGCTCCGGGCCACAGAGACGGTGTCAGTGGTAGCCTAGAGAGGCCGCTAACAGACAGGA
GCCGAACGGGGGCTTCCGCTCAGCAGAGAGGCAAGATGGCTACGGCAGGGGGTGGCTCTGGGGCTGACCCGGGAAGTCGGGGTCTCCTTC
GCCTTCTGTCTTTCTGCGTCCTACTAGCAGGTTTGTGCAGGGGAAACTCAGTGGAGAGGAAGATATATATCCCCTTAAATAAAACAGCTC
CCTGTGTTCGCCTGCTCAACGCCACTCATCAGATTGGCTGCCAGTGCCGCCTGATCTTTGACAACCTGAAGAAATCCATCATGTACACCC
TGACCAGCAACATCCCCGAGATCACGCCCTTCCTGATGTTCATCATCCTCGGTATACCCCTGCCTCTGGGAACCATAACCATCCTCTGCA
TTGATCTCGGCACTGACATGGTCCCTGCCATCTCCTTGGCTTATGAGTCAGCTGAAAGCGACATCATGAAGAGGCTTCCAAGGAACCCAA
AGACGGATAATCTGGTGAACCACCGTCTCATTGGCATGGCCTATGGACAGATTGGGATGATCCAGGCTCTGGCTGGATTCTTTACCTACT
TTGTAATCCTGGCTGAGAATGGTTTTAGGCCTGTTGATCTGCTGGGCATCCGCCTCCACTGGGAAGATAAATACTTGAATGACCTGGAGG
ACAGCTACGGACAGCAGTGGACCTATGAGCAACGAAAAGTTGTGGAGTTCACATGCCAAACGGCCTTTTTTGTCACCATCGTGGTTGTGC
AGTGGGCGGATCTCATCATCTCCAAGACTCGCCGCAACTCACTTTTCCAGCAGGGCATGAGAAACAAAGTCTTAATATTTGGGATCCTGG
AGGAGACACTCTTGGCTGCATTTCTGTCCTACACTCCAGGCATGGACGTGGCCCTGCGAATGTACCCACTCAAGATAACCTGGTGGCTCT
GTGCCATTCCCTACAGTATTCTCATCTTCGTCTATGATGAAATCAGAAAACTCCTCATCCGTCAGCACCCGGATGGCTGGGTGGAAAGGG
AGACGTACTACTAAACTCAGCAGATGAAGAGCTTCATGTGACACAGGGGTGTTGTGAGAGCTGGGATGGGGCCAGAGATTATAAGTTTGA
CACAACATCTGAGACACTAGGATGAATTATCTTGGATGAGAAAGATGGGCAATCCTGGGCTGGCTTGAGGGAATCATGGGCAGAGGATGA
GGTGGGCTGAAGGGAAGCCCAGCCTGCATCTAGCTGGAGCCCCGCAGGGAGGGGCATGGTCCTGCTGAATCCCGTAGCCAGTCTAGACAG

>57901_57901_1_NCSTN-ATP1A4_NCSTN_chr1_160314616_ENST00000294785_ATP1A4_chr1_160145882_ENST00000368081_length(amino acids)=322AA_BP=64
MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQCRLIFDNLKKSIMYTLTSNIPEITPFL
MFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPV
DLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYT

--------------------------------------------------------------
>57901_57901_2_NCSTN-ATP1A4_NCSTN_chr1_160314616_ENST00000368063_ATP1A4_chr1_160145882_ENST00000368081_length(transcript)=1467nt_BP=410nt
AGAGACGGTGTCAGTGGTAGCCTAGAGAGGCCGCTAACAGACAGGAGCCGAACGGGGGCTTCCGCTCAGCAGAGAGGCAAGATGGCTACG
GCAGGGGGTGGCTCTGGGGCTGACCCGGGAAGTCGGGGTCTCCTTCGCCTTCTGTCTTTCTGCGTCCTACTAGCAGTGTCACTGTCAATG
GCGCTACATGGACTTTGTAATAACCCTTTGAGGCACATAGCTGGGTGCCATGTAGAACATGTATCTGTTACGATAAGTGTGTGCCCAAGA
AATCAGAAGAATGGACTTTAATCTCATTTTAGAAAGTTTGTGCAGGGGAAACTCAGTGGAGAGGAAGATATATATCCCCTTAAATAAAAC
AGCTCCCTGTGTTCGCCTGCTCAACGCCACTCATCAGATTGGCTGCCAGTGCCGCCTGATCTTTGACAACCTGAAGAAATCCATCATGTA
CACCCTGACCAGCAACATCCCCGAGATCACGCCCTTCCTGATGTTCATCATCCTCGGTATACCCCTGCCTCTGGGAACCATAACCATCCT
CTGCATTGATCTCGGCACTGACATGGTCCCTGCCATCTCCTTGGCTTATGAGTCAGCTGAAAGCGACATCATGAAGAGGCTTCCAAGGAA
CCCAAAGACGGATAATCTGGTGAACCACCGTCTCATTGGCATGGCCTATGGACAGATTGGGATGATCCAGGCTCTGGCTGGATTCTTTAC
CTACTTTGTAATCCTGGCTGAGAATGGTTTTAGGCCTGTTGATCTGCTGGGCATCCGCCTCCACTGGGAAGATAAATACTTGAATGACCT
GGAGGACAGCTACGGACAGCAGTGGACCTATGAGCAACGAAAAGTTGTGGAGTTCACATGCCAAACGGCCTTTTTTGTCACCATCGTGGT
TGTGCAGTGGGCGGATCTCATCATCTCCAAGACTCGCCGCAACTCACTTTTCCAGCAGGGCATGAGAAACAAAGTCTTAATATTTGGGAT
CCTGGAGGAGACACTCTTGGCTGCATTTCTGTCCTACACTCCAGGCATGGACGTGGCCCTGCGAATGTACCCACTCAAGATAACCTGGTG
GCTCTGTGCCATTCCCTACAGTATTCTCATCTTCGTCTATGATGAAATCAGAAAACTCCTCATCCGTCAGCACCCGGATGGCTGGGTGGA
AAGGGAGACGTACTACTAAACTCAGCAGATGAAGAGCTTCATGTGACACAGGGGTGTTGTGAGAGCTGGGATGGGGCCAGAGATTATAAG
TTTGACACAACATCTGAGACACTAGGATGAATTATCTTGGATGAGAAAGATGGGCAATCCTGGGCTGGCTTGAGGGAATCATGGGCAGAG
GATGAGGTGGGCTGAAGGGAAGCCCAGCCTGCATCTAGCTGGAGCCCCGCAGGGAGGGGCATGGTCCTGCTGAATCCCGTAGCCAGTCTA

>57901_57901_2_NCSTN-ATP1A4_NCSTN_chr1_160314616_ENST00000368063_ATP1A4_chr1_160145882_ENST00000368081_length(amino acids)=302AA_BP=44
MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQCRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCID
LGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDS
YGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCA

--------------------------------------------------------------
>57901_57901_3_NCSTN-ATP1A4_NCSTN_chr1_160314616_ENST00000392212_ATP1A4_chr1_160145882_ENST00000368081_length(transcript)=1187nt_BP=130nt
ATGGACTTTAATCTCATTTTAGAAAGTTTGTGCAGGGGAAACTCAGTGGAGAGGAAGATATATATCCCCTTAAATAAAACAGCTCCCTGT
GTTCGCCTGCTCAACGCCACTCATCAGATTGGCTGCCAGTGCCGCCTGATCTTTGACAACCTGAAGAAATCCATCATGTACACCCTGACC
AGCAACATCCCCGAGATCACGCCCTTCCTGATGTTCATCATCCTCGGTATACCCCTGCCTCTGGGAACCATAACCATCCTCTGCATTGAT
CTCGGCACTGACATGGTCCCTGCCATCTCCTTGGCTTATGAGTCAGCTGAAAGCGACATCATGAAGAGGCTTCCAAGGAACCCAAAGACG
GATAATCTGGTGAACCACCGTCTCATTGGCATGGCCTATGGACAGATTGGGATGATCCAGGCTCTGGCTGGATTCTTTACCTACTTTGTA
ATCCTGGCTGAGAATGGTTTTAGGCCTGTTGATCTGCTGGGCATCCGCCTCCACTGGGAAGATAAATACTTGAATGACCTGGAGGACAGC
TACGGACAGCAGTGGACCTATGAGCAACGAAAAGTTGTGGAGTTCACATGCCAAACGGCCTTTTTTGTCACCATCGTGGTTGTGCAGTGG
GCGGATCTCATCATCTCCAAGACTCGCCGCAACTCACTTTTCCAGCAGGGCATGAGAAACAAAGTCTTAATATTTGGGATCCTGGAGGAG
ACACTCTTGGCTGCATTTCTGTCCTACACTCCAGGCATGGACGTGGCCCTGCGAATGTACCCACTCAAGATAACCTGGTGGCTCTGTGCC
ATTCCCTACAGTATTCTCATCTTCGTCTATGATGAAATCAGAAAACTCCTCATCCGTCAGCACCCGGATGGCTGGGTGGAAAGGGAGACG
TACTACTAAACTCAGCAGATGAAGAGCTTCATGTGACACAGGGGTGTTGTGAGAGCTGGGATGGGGCCAGAGATTATAAGTTTGACACAA
CATCTGAGACACTAGGATGAATTATCTTGGATGAGAAAGATGGGCAATCCTGGGCTGGCTTGAGGGAATCATGGGCAGAGGATGAGGTGG
GCTGAAGGGAAGCCCAGCCTGCATCTAGCTGGAGCCCCGCAGGGAGGGGCATGGTCCTGCTGAATCCCGTAGCCAGTCTAGACAGTAAAT

>57901_57901_3_NCSTN-ATP1A4_NCSTN_chr1_160314616_ENST00000392212_ATP1A4_chr1_160145882_ENST00000368081_length(amino acids)=302AA_BP=44
MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQCRLIFDNLKKSIMYTLTSNIPEITPFLMFIILGIPLPLGTITILCID
LGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDS
YGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYTPGMDVALRMYPLKITWWLCA

--------------------------------------------------------------
>57901_57901_4_NCSTN-ATP1A4_NCSTN_chr1_160314616_ENST00000535857_ATP1A4_chr1_160145882_ENST00000368081_length(transcript)=1258nt_BP=201nt
AGAGAGGCAAGATGGCTACGGCAGGGGGTGGCTCTGGGGCTGACCCGGGAAGTCGGGGTCTCCTTCGCCTTCTGTCTTTCTGCGTCCTAC
TAGCAGGTTTGTGCAGGGGAAACTCAGTGGAGAGGAAGATATATATCCCCTTAAATAAAACAGCTCCCTGTGTTCGCCTGCTCAACGCCA
CTCATCAGATTGGCTGCCAGTGCCGCCTGATCTTTGACAACCTGAAGAAATCCATCATGTACACCCTGACCAGCAACATCCCCGAGATCA
CGCCCTTCCTGATGTTCATCATCCTCGGTATACCCCTGCCTCTGGGAACCATAACCATCCTCTGCATTGATCTCGGCACTGACATGGTCC
CTGCCATCTCCTTGGCTTATGAGTCAGCTGAAAGCGACATCATGAAGAGGCTTCCAAGGAACCCAAAGACGGATAATCTGGTGAACCACC
GTCTCATTGGCATGGCCTATGGACAGATTGGGATGATCCAGGCTCTGGCTGGATTCTTTACCTACTTTGTAATCCTGGCTGAGAATGGTT
TTAGGCCTGTTGATCTGCTGGGCATCCGCCTCCACTGGGAAGATAAATACTTGAATGACCTGGAGGACAGCTACGGACAGCAGTGGACCT
ATGAGCAACGAAAAGTTGTGGAGTTCACATGCCAAACGGCCTTTTTTGTCACCATCGTGGTTGTGCAGTGGGCGGATCTCATCATCTCCA
AGACTCGCCGCAACTCACTTTTCCAGCAGGGCATGAGAAACAAAGTCTTAATATTTGGGATCCTGGAGGAGACACTCTTGGCTGCATTTC
TGTCCTACACTCCAGGCATGGACGTGGCCCTGCGAATGTACCCACTCAAGATAACCTGGTGGCTCTGTGCCATTCCCTACAGTATTCTCA
TCTTCGTCTATGATGAAATCAGAAAACTCCTCATCCGTCAGCACCCGGATGGCTGGGTGGAAAGGGAGACGTACTACTAAACTCAGCAGA
TGAAGAGCTTCATGTGACACAGGGGTGTTGTGAGAGCTGGGATGGGGCCAGAGATTATAAGTTTGACACAACATCTGAGACACTAGGATG
AATTATCTTGGATGAGAAAGATGGGCAATCCTGGGCTGGCTTGAGGGAATCATGGGCAGAGGATGAGGTGGGCTGAAGGGAAGCCCAGCC

>57901_57901_4_NCSTN-ATP1A4_NCSTN_chr1_160314616_ENST00000535857_ATP1A4_chr1_160145882_ENST00000368081_length(amino acids)=322AA_BP=64
MATAGGGSGADPGSRGLLRLLSFCVLLAGLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQCRLIFDNLKKSIMYTLTSNIPEITPFL
MFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLPRNPKTDNLVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPV
DLLGIRLHWEDKYLNDLEDSYGQQWTYEQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQGMRNKVLIFGILEETLLAAFLSYT

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Fusion Gene PPI Analysis for NCSTN-ATP1A4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneATP1A4chr1:160314616chr1:160145882ENST000004707050590_920166.0phosphoinositide-3 kinase


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneATP1A4chr1:160314616chr1:160145882ENST00000368081142290_92770.33333333333341030.0phosphoinositide-3 kinase


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NCSTN-ATP1A4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NCSTN-ATP1A4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource