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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDRG2-KIF3A (FusionGDB2 ID:57994)

Fusion Gene Summary for NDRG2-KIF3A

check button Fusion gene summary
Fusion gene informationFusion gene name: NDRG2-KIF3A
Fusion gene ID: 57994
HgeneTgene
Gene symbol

NDRG2

KIF3A

Gene ID

57447

11127

Gene nameNDRG family member 2kinesin family member 3A
SynonymsSYLDFLA10|KLP-20
Cytomap

14q11.2

5q31.1

Type of geneprotein-codingprotein-coding
Descriptionprotein NDRG2N-myc downstream regulator 2N-myc downstream-regulated gene 2 proteinNDR1-related protein NDR2cytoplasmic protein Ndr1syld709613 proteinkinesin-like protein KIF3Akinesin family protein 3Amicrotubule plus end-directed kinesin motor 3A
Modification date2020031320200313
UniProtAcc

Q9UN36

Q9Y496

Ensembl transtripts involved in fusion geneENST00000360463, ENST00000397847, 
ENST00000397851, ENST00000397853, 
ENST00000397855, ENST00000397856, 
ENST00000553503, ENST00000554104, 
ENST00000554143, ENST00000555158, 
ENST00000556147, ENST00000298684, 
ENST00000298687, ENST00000350792, 
ENST00000397844, ENST00000397858, 
ENST00000403829, ENST00000554277, 
ENST00000378735, ENST00000378746, 
ENST00000403231, ENST00000487055, 
Fusion gene scores* DoF score17 X 14 X 3=7149 X 5 X 6=270
# samples 189
** MAII scorelog2(18/714*10)=-1.98792716769943
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/270*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDRG2 [Title/Abstract] AND KIF3A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDRG2(21484932)-KIF3A(132035266), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NDRG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KIF3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-8185-01ANDRG2chr14

21484932

-KIF3Achr5

132035266

-


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Fusion Gene ORF analysis for NDRG2-KIF3A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360463ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000360463ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000360463ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000360463ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397847ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397847ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397847ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397847ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397851ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397851ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397851ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397851ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397853ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397853ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397853ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397853ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397855ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397855ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397855ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397855ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397856ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397856ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397856ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000397856ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000553503ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000553503ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000553503ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000553503ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000554104ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000554104ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000554104ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000554104ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000554143ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000554143ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000554143ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000554143ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000555158ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000555158ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000555158ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000555158ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000556147ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000556147ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000556147ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
5CDS-intronENST00000556147ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000298684ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000298684ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000298684ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000298684ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000298687ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000298687ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000298687ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000298687ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000350792ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000350792ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000350792ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000350792ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000397844ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000397844ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000397844ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000397844ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000397858ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000397858ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000397858ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000397858ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000403829ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000403829ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000403829ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000403829ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000554277ENST00000378735NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000554277ENST00000378746NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000554277ENST00000403231NDRG2chr14

21484932

-KIF3Achr5

132035266

-
intron-intronENST00000554277ENST00000487055NDRG2chr14

21484932

-KIF3Achr5

132035266

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NDRG2-KIF3A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDRG2-KIF3A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21484932/:132035266)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDRG2

Q9UN36

KIF3A

Q9Y496

FUNCTION: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269|PubMed:12845671, ECO:0000269|PubMed:16103061, ECO:0000269|PubMed:21247902}.FUNCTION: Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation. Plays a role in centriole cohesion and subdistal appendage organization and function. Regulates the formation of the subdistal appendage via recruitment of DCTN1 to the centriole. Also required for ciliary basal feet formation and microtubule anchoring to mother centriole. {ECO:0000250|UniProtKB:P28741}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NDRG2-KIF3A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NDRG2-KIF3A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDRG2-KIF3A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDRG2-KIF3A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource