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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NDRG2-SPARC (FusionGDB2 ID:58000)

Fusion Gene Summary for NDRG2-SPARC

Fusion gene summary

Fusion gene information	Fusion gene name: NDRG2-SPARC
	Fusion gene ID: 58000
		Hgene	Tgene
	Gene symbol	NDRG2	SPARC
	Gene ID	57447	6678
	Gene name	NDRG family member 2	secreted protein acidic and cysteine rich
	Synonyms	SYLD	BM-40\|OI17\|ON\|ONT
	Cytomap	14q11.2	5q33.1
	Type of gene	protein-coding	protein-coding
	Description	protein NDRG2N-myc downstream regulator 2N-myc downstream-regulated gene 2 proteinNDR1-related protein NDR2cytoplasmic protein Ndr1syld709613 protein	SPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin)
	Modification date	20200313	20200329
	UniProtAcc	Q9UN36	SMAP2,SMOC2
	Ensembl transtripts involved in fusion gene	ENST00000298684, ENST00000298687, ENST00000350792, ENST00000360463, ENST00000397844, ENST00000397851, ENST00000397853, ENST00000397855, ENST00000397856, ENST00000397858, ENST00000403829, ENST00000553503, ENST00000554104, ENST00000554143, ENST00000555158, ENST00000556147, ENST00000397847, ENST00000554277,	ENST00000537849, ENST00000231061,
Fusion gene scores	* DoF score	17 X 14 X 3=714	34 X 31 X 7=7378
	# samples	18	38
	** MAII score	log2(18/714*10)=-1.98792716769943 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(38/7378*10)=-4.27915846536387 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NDRG2 [Title/Abstract] AND SPARC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NDRG2(21486922)-SPARC(151049345), # samples:1
Anticipated loss of major functional domain due to fusion event.	NDRG2-SPARC seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. NDRG2-SPARC seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SPARC	GO:0001937	negative regulation of endothelial cell proliferation	12867428
Tgene	SPARC	GO:0010595	positive regulation of endothelial cell migration	12867428
Tgene	SPARC	GO:0016525	negative regulation of angiogenesis	12867428
Tgene	SPARC	GO:0022604	regulation of cell morphogenesis	15389586

Fusion gene breakpoints across NDRG2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPARC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-HT-7680-01A	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-

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Fusion Gene ORF analysis for NDRG2-SPARC

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000298684	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000298687	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000350792	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000360463	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000397844	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000397851	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000397853	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000397855	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000397856	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000397858	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000403829	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000553503	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000554104	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000554143	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000555158	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
5CDS-intron	ENST00000556147	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000298687	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000350792	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000397844	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000397853	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000397855	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000397856	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000553503	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000554104	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
Frame-shift	ENST00000555158	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
In-frame	ENST00000298684	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
In-frame	ENST00000360463	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
In-frame	ENST00000397851	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
In-frame	ENST00000397858	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
In-frame	ENST00000403829	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
In-frame	ENST00000554143	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
In-frame	ENST00000556147	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
intron-3CDS	ENST00000397847	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
intron-3CDS	ENST00000554277	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
intron-intron	ENST00000397847	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-
intron-intron	ENST00000554277	ENST00000537849	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000403829	NDRG2	chr14	21486922	-	ENST00000231061	SPARC	chr5	151049345	-	3879	822	9	1403	464
ENST00000397858	NDRG2	chr14	21486922	-	ENST00000231061	SPARC	chr5	151049345	-	3976	919	106	1500	464
ENST00000360463	NDRG2	chr14	21486922	-	ENST00000231061	SPARC	chr5	151049345	-	3977	920	149	1501	450
ENST00000556147	NDRG2	chr14	21486922	-	ENST00000231061	SPARC	chr5	151049345	-	4811	1754	911	2335	474
ENST00000554143	NDRG2	chr14	21486922	-	ENST00000231061	SPARC	chr5	151049345	-	3911	854	83	1435	450
ENST00000397851	NDRG2	chr14	21486922	-	ENST00000231061	SPARC	chr5	151049345	-	3953	896	83	1477	464
ENST00000298684	NDRG2	chr14	21486922	-	ENST00000231061	SPARC	chr5	151049345	-	3753	696	12	1277	421

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000403829	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-	0.000912377	0.9990876
ENST00000397858	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-	0.001227489	0.99877244
ENST00000360463	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-	0.000939825	0.9990602
ENST00000556147	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-	0.000996888	0.9990031
ENST00000554143	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-	0.000812446	0.9991875
ENST00000397851	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-	0.001105991	0.99889404
ENST00000298684	ENST00000231061	NDRG2	chr14	21486922	-	SPARC	chr5	151049345	-	0.001139995	0.99886

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Fusion Genomic Features for NDRG2-SPARC

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDRG2-SPARC

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:21486922/chr5:151049345)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NDRG2 Q9UN36	SPARC SMAP2,SMOC2
FUNCTION: Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation. {ECO:0000269\|PubMed:12845671, ECO:0000269\|PubMed:16103061, ECO:0000269\|PubMed:21247902}.	446

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SPARC

chr14:21486922

chr5:151049345

ENST00000231061

274_285

110

304.0

Calcium binding

Tgene

SPARC

chr14:21486922

chr5:151049345

ENST00000231061

261_296

110

304.0

Domain

Note=EF-hand

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SPARC

chr14:21486922

chr5:151049345

ENST00000231061

22_69

110

304.0

Compositional bias

Note=Asp/Glu-rich (acidic%3B binds calcium)

Tgene

SPARC

chr14:21486922

chr5:151049345

ENST00000231061

71_93

110

304.0

Domain

Note=Follistatin-like

Tgene

SPARC

chr14:21486922

chr5:151049345

ENST00000231061

89_151

110

304.0

Domain

Kazal-like

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Fusion Gene Sequence for NDRG2-SPARC

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>58000_58000_1_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000298684_SPARC_chr5_151049345_ENST00000231061_length(transcript)=3753nt_BP=696nt
TGCCAGGCCACCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGTTGCCAGGACAGACGCCTGAGGCGGCCAAGACT
CACTCTGTGGAGACACCATACGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGAT
GTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAGTTCGAGGACATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTG
GATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGC
GTCCTGCAGTACCTAAATTTCTCTACAATAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGGCGAGATATGCTCTAACAGGCCTC
ACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAAT
ATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGT
GATATCACCCTCAGGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGTGCAGCAATGACAACAAGACC
TTCGACTCTTCCTGCCACTTCTTTGCCACAAAGTGCACCCTGGAGGGCACCAAGAAGGGCCACAAGCTCCACCTGGACTACATCGGGCCT
TGCAAATACATCCCCCCTTGCCTGGACTCTGAGCTGACCGAATTCCCCCTGCGCATGCGGGACTGGCTCAAGAACGTCCTGGTCACCCTG
TATGAGAGGGATGAGGACAACAACCTTCTGACTGAGAAGCAGAAGCTGCGGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCA
GGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTG
GACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGC
TTTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGAC
AAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCTCTCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGT
TTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGTGCTAACATAGATTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCC
AAGACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTT
GCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGCTCTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGT
TCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGG
AGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAAC
CCACCAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGC
CCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTC
AGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGAC
TGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGT
TCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTCCTCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAG
AAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAAT
CATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGC
ATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACACATGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTG
CAAACACATTATGCTTTTGCACACACACACCTGTACACACACACCGGCATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAG
TTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCACTACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTAT
TAATCATGGTCATTCATTCATTCATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACAC
AGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATT
GCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCATGAGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTG
TTCCGTACGGCAGCCACTACCCACATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTA
GCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAG
TTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGCACTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTT
GAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCCAAGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAG
ATGTCATTTCCCCTCTCTTATTTTAAGTTATGTTAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTC
TTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTTGGTGCTGGCCATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAA
TCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCATTGGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATG
TGTTAGGGGATCTTATGAGTAGGCAGCGTGCGTGATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTT

>58000_58000_1_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000298684_SPARC_chr5_151049345_ENST00000231061_length(amino acids)=421AA_BP=228
MAELQEVQITEEKPLLPGQTPEAAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPG
MEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITH
APNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYI
PPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHP

--------------------------------------------------------------
>58000_58000_2_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000360463_SPARC_chr5_151049345_ENST00000231061_length(transcript)=3977nt_BP=920nt
TCTCCCCACCCCCCGCCTGCCCGCGATCGCCCTCTATTTATAGCGGCCCCCCGCATTCCCCGCCCCCACCTCCCCGCCTTGTTGTCCAAC
TTCTCCCGGAGCAGCCGGAGAGCAGGCGTCGGGACGCAGCAAAGAGAGGAGAGGCCACCATGGCGGAGCTGCAGGAGGTGCAGATCACAG
AGGAGAAGCCACTGTTGCCAGGACAGACGCCTGAGGCGGCCAAGACTCACTCTGTGGAGACACCATACGGCTCTGTCACTTTCACTGTCT
ATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAGT
TCGAGGACATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGG
GATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTGCAGTACCTAAATTTCTCTACAATAATTGGAGTTGGTG
TTGGAGCTGGAGCCTACATCCTGGCGAGATATGCTCTTAACCACCCGGACACTGTTGAAGGTCTTGTCCTCATCAACATTGATCCCAATG
CCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACAGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGG
AAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGA
ACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAGGTGTCCTGTGATGCTGGTGGTAGGAGACCAAG
CACCTCATGAAGATGCAGTGGTGTGCAGCAATGACAACAAGACCTTCGACTCTTCCTGCCACTTCTTTGCCACAAAGTGCACCCTGGAGG
GCACCAAGAAGGGCCACAAGCTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCTTGCCTGGACTCTGAGCTGACCGAATTCC
CCCTGCGCATGCGGGACTGGCTCAAGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACAACCTTCTGACTGAGAAGCAGAAGC
TGCGGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACT
ATAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCTC
CACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTGG
ATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCT
CTCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGTGCTAACATAGAT
TTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCC
ACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGCT
CTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATTTC
ATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATGG
TTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAAG
ATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTT
TCACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCT
CTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGT
AGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTC
CTCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAACT
CGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCAA
AATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACACA
TGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGTACACACACACCG
GCATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCAC
TACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTCATTCATTCACAAAATATTTATGA
TGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAG
TCCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCATGA
GTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCACATGTAACTTTTTAAGATTTAAA
TTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCC
TATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGCA
CTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCCA
AGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGTTAAGATTACTAAA
ACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTTG
GTGCTGGCCATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCATT
GGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAGGCAGCGTGCGTGATCCTTGCTCCC
CTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAATACTGTTTCTGATAAAAACGTGCTGTAAAGGAAATAAAGCAG

>58000_58000_2_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000360463_SPARC_chr5_151049345_ENST00000231061_length(amino acids)=450AA_BP=257
MAELQEVQITEEKPLLPGQTPEAAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPG
MEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIP
EMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVCSNDNKTFDSSC
HFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPV
ELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI

--------------------------------------------------------------
>58000_58000_3_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000397851_SPARC_chr5_151049345_ENST00000231061_length(transcript)=3953nt_BP=896nt
GGGTCTGCGGGAAGCCCGAGCCGGGGCGGGCCCGAGTCAAAGGCAAGTGAAGGTGGAAGCGGCCGCGGCGGCAGCAGGCCACCATGGCGG
AGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGTTGCCAGGACAGACGCCTGAGGCGGCCAAGGAGGCTGAGTTAGCTGCCCGAA
TCCTCCTGGACCAGGGACAGACTCACTCTGTGGAGACACCATACGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCC
CAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAGTTCGAGGACATGCAGGAAATCATTC
AGAACTTTGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACC
AGCTTGCAGACATGATCCCTTGCGTCCTGCAGTACCTAAATTTCTCTACAATAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGG
CGAGATATGCTCTTAACCACCCGGACACTGTTGAAGGTCTTGTCCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAG
CCCACAAGCTAACAGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGT
TGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACC
TGAACTTTGAGCGTGGAGGTGATATCACCCTCAGGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGT
GCAGCAATGACAACAAGACCTTCGACTCTTCCTGCCACTTCTTTGCCACAAAGTGCACCCTGGAGGGCACCAAGAAGGGCCACAAGCTCC
ACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCTTGCCTGGACTCTGAGCTGACCGAATTCCCCCTGCGCATGCGGGACTGGCTCA
AGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACAACCTTCTGACTGAGAAGCAGAAGCTGCGGGTGAAGAAGATCCATGAGA
ATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTAC
ACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCA
TGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCA
TCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCTCTCTTTAACCCTCCCCTTCGTGTT
TCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGTGCTAACATAGATTTAAGTGAATACATTAACGGTGCT
AAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATTTTT
CTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGCTCTGCCTTAAACACACATTGCAGCT
TCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTG
GGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGT
GGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAAT
ATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACATTAGGCTGTTGGTTCAAAC
TTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTC
TTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGT
GGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTCCTCCTTTTCTTCACCCTCCCCTTT
TTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGA
AAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACTTAGAAAC
TGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACACATGAGCATACATGTCTACACATGAC
TACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGTACACACACACCGGCATGTTTATACACAGGGAGTGTA
TGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCACTACCACCATTATCAGCACCAGACT
GAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTCATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCC
ATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACATTAGATAAT
GACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCATGAGTATGTGTAACAGGAGGACACAGC
ATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCACATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAAC
GCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAAT
CTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGCACTTTTCAAAGCTCATGCATGTTCA
TCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCCAAGAAATGTGCTCAATTGCAATGGG
CCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGTTAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCA
AACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTTGGTGCTGGCCATTTGAGGAATGCAA
GCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCATTGGCTCATTCAGTCATTCGGCGACA
TTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAGGCAGCGTGCGTGATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCA

>58000_58000_3_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000397851_SPARC_chr5_151049345_ENST00000231061_length(amino acids)=464AA_BP=271
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQE
IIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMD
WAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDA
VVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKI
HENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGC

--------------------------------------------------------------
>58000_58000_4_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000397858_SPARC_chr5_151049345_ENST00000231061_length(transcript)=3976nt_BP=919nt
CGGCCCCCCGCATTCCCCGCCCCCACCTCCCCGCCTTGTTGTCCAACTTCTCCCGGAGCAGCCGGAGAGCAGGCGTCGGGACGCAGCAAA
GAGAGGAGAGGCCACCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGTTGCCAGGACAGACGCCTGAGGCGGCCAA
GGAGGCTGAGTTAGCTGCCCGAATCCTCCTGGACCAGGGACAGACTCACTCTGTGGAGACACCATACGGCTCTGTCACTTTCACTGTCTA
TGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAGTT
CGAGGACATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGG
ATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTGCAGTACCTAAATTTCTCTACAATAATTGGAGTTGGTGT
TGGAGCTGGAGCCTACATCCTGGCGAGATATGCTCTTAACCACCCGGACACTGTTGAAGGTCTTGTCCTCATCAACATTGATCCCAATGC
CAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACAGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGA
AGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAA
CAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAGGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGC
ACCTCATGAAGATGCAGTGGTGTGCAGCAATGACAACAAGACCTTCGACTCTTCCTGCCACTTCTTTGCCACAAAGTGCACCCTGGAGGG
CACCAAGAAGGGCCACAAGCTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCTTGCCTGGACTCTGAGCTGACCGAATTCCC
CCTGCGCATGCGGGACTGGCTCAAGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACAACCTTCTGACTGAGAAGCAGAAGCT
GCGGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTA
TAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCTCC
ACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTGGA
TGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCTC
TCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGTGCTAACATAGATT
TAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCA
CACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGCTC
TGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATTTCA
TTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATGGT
TTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAAGA
TTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTT
CACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCTC
TGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTA
GAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTCC
TCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAACTC
GTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCAAA
ATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACACAT
GAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGTACACACACACCGG
CATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCACT
ACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTCATTCATTCACAAAATATTTATGAT
GTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAGT
CCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCATGAG
TATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCACATGTAACTTTTTAAGATTTAAAT
TTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCCT
ATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGCAC
TTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCCAA
GAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGTTAAGATTACTAAAA
CAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTTGG
TGCTGGCCATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCATTG
GCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAGGCAGCGTGCGTGATCCTTGCTCCCC
TGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAATACTGTTTCTGATAAAAACGTGCTGTAAAGGAAATAAAGCAGA

>58000_58000_4_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000397858_SPARC_chr5_151049345_ENST00000231061_length(amino acids)=464AA_BP=271
MAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQE
IIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMD
WAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDA
VVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKI
HENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGC

--------------------------------------------------------------
>58000_58000_5_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000403829_SPARC_chr5_151049345_ENST00000231061_length(transcript)=3879nt_BP=822nt
CTCACCGGGTTGGGGACAGGGATGGAAAATGGTGGTTCCATGCAGGCCACCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAG
CCACTGTTGCCAGGACAGACGCCTGAGGCGGCCAAGACTCACTCTGTGGAGACACCATACGGCTCTGTCACTTTCACTGTCTATGGCACC
CCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAATCTTGCTTCCAGCCACTGTTTCAGTTCGAGGAC
ATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAGAGGGAGCCCCTGTGTTCCCTTTGGGATATCAG
TACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTGCAGTACCTAAATTTCTCTACAATAATTGGAGTTGGTGTTGGAGCT
GGAGCCTACATCCTGGCGAGATATGCTCTTAACCACCCGGACACTGTTGAAGGTCTTGTCCTCATCAACATTGATCCCAATGCCAAGGGT
TGGATGGATTGGGCAGCCCACAAGCTAACAGGCCTCACCTCTTCCATTCCGGAGATGATCCTTGGACATCTTTTCAGCCAGGAAGAGCTC
TCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACCTGGATAACATTGAATTGTACTGGAACAGCTAC
AACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAGGTGTCCTGTGATGCTGGTGGTAGGAGACCAAGCACCTCAT
GAAGATGCAGTGGTGTGCAGCAATGACAACAAGACCTTCGACTCTTCCTGCCACTTCTTTGCCACAAAGTGCACCCTGGAGGGCACCAAG
AAGGGCCACAAGCTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCTTGCCTGGACTCTGAGCTGACCGAATTCCCCCTGCGC
ATGCGGGACTGGCTCAAGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACAACCTTCTGACTGAGAAGCAGAAGCTGCGGGTG
AAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGCTGGCCCGGGACTTCGAGAAGAACTATAACATG
TACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGTACCTCTCCCACACCGAGCTGGCTCCACTGCGT
GCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGGACAATGACAAGTACATCGCCCTGGATGAGTGG
GCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCCACTCCTTCCACAGTACCGGATTCTCTCTTTAA
CCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCCTGGAGACAAGGTGCTAACATAGATTTAAGTGA
ATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGTAACTTAACTATTAAGGCCTTTTCCACACGCAT
TAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACATGGGTGGACACGGATCTGCTGGGCTCTGCCTTA
AACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTACCGAGTCAGACTTTGTGTTCATTTCATTTCAGG
GTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACAGACACACGATGTTGTCAAGGATGGTTTTGGGA
CTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTGCCTGAGGCTGTAACTGAGAGAAAGATTCTGGG
GCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCCTTTACCTTTCAGTGCAGTTTCTTTTCACATTA
GGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGCGCATCCTGCAGGGCTTCTCCTCCTCTGTCTTT
TGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGAAGGCCAAAATCAAGAGTGAGATGTAGAAAGTT
GTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGATTGTCATAAGGTTTTTAGCATGTTCCTCCTTTT
CTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATGGTCGGATCTCACAGGCTGAGAACTCGTTCACC
TCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATGTGAAGAGTTTCACAAATCCTTCAAAATAAAAA
GTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACCTTATTATCCTGACACAAAAACACATGAGCATA
CATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCACACACACACCTGTACACACACACCGGCATGTTT
ATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGACCTGTGGTTTAACCCTTTTGATCACTACCACCA
TTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATTCATTCATTCACAAAATATTTATGATGTATTTA
CTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAGCATTTGTTCATTTGGAGCTTAGAGTCCAGGAG
GAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATGAAGGGAGAGTAGGAGAGACCATGAGTATGTGT
AACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCCACATGTAACTTTTTAAGATTTAAATTTAAATT
AGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGAGCCATGCATGATTAGTGGTTACCCTATTGAAT
AGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCTAGATCATCATAAGACTACAGAGCACTTTTCAA
AGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCCCTTAGAGATAGAGAAACAGACCCAAGAAATGT
GCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATTTTAAGTTATGTTAAGATTACTAAAACAATAAA
AGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAGCAGTAGGAGAGATTGGCCCATTTGGTGCTGGC
CATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGAGGAATTGAAGTAAATTTCAGCATTGGCTCATT
CAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAGGCAGCGTGCGTGATCCTTGCTCCCCTGGAGCT
TTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAATACTGTTTCTGATAAAAACGTGCTGTAAAGGAAATAAAGCAGAGAACTAT

>58000_58000_5_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000403829_SPARC_chr5_151049345_ENST00000231061_length(amino acids)=464AA_BP=271
MGTGMENGGSMQATMAELQEVQITEEKPLLPGQTPEAAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQE
IIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMD
WAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDA
VVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKI
HENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGC

--------------------------------------------------------------
>58000_58000_6_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000554143_SPARC_chr5_151049345_ENST00000231061_length(transcript)=3911nt_BP=854nt
GGGTCTGCGGGAAGCCCGAGCCGGGGCGGGCCCGAGTCAAAGGCAAGTGAAGGTGGAAGCGGCCGCGGCGGCAGCAGGCCACCATGGCGG
AGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGTTGCCAGGACAGACGCCTGAGGCGGCCAAGACTCACTCTGTGGAGACACCAT
ACGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAAT
CTTGCTTCCAGCCACTGTTTCAGTTCGAGGACATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAG
AGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTGCAGTACCTAAATT
TCTCTACAATAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGGCGAGATATGCTCTTAACCACCCGGACACTGTTGAAGGTCTTG
TCCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACAGGCCTCACCTCTTCCATTCCGGAGATGA
TCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACC
TGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAGGTGTCCTG
TGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGTGCAGCAATGACAACAAGACCTTCGACTCTTCCTGCCACTTCT
TTGCCACAAAGTGCACCCTGGAGGGCACCAAGAAGGGCCACAAGCTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCTTGCC
TGGACTCTGAGCTGACCGAATTCCCCCTGCGCATGCGGGACTGGCTCAAGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACA
ACCTTCTGACTGAGAAGCAGAAGCTGCGGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGC
TGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGT
ACCTCTCCCACACCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGG
ACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCC
ACTCCTTCCACAGTACCGGATTCTCTCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCC
TGGAGACAAGGTGCTAACATAGATTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGT
AACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACAT
GGGTGGACACGGATCTGCTGGGCTCTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTAC
CGAGTCAGACTTTGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACA
GACACACGATGTTGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTG
CCTGAGGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCC
TTTACCTTTCAGTGCAGTTTCTTTTCACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGC
GCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGA
AGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGAT
TGTCATAAGGTTTTTAGCATGTTCCTCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATG
GTCGGATCTCACAGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATG
TGAAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACC
TTATTATCCTGACACAAAAACACATGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCAC
ACACACACCTGTACACACACACCGGCATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGAC
CTGTGGTTTAACCCTTTTGATCACTACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATT
CATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAG
CATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATG
AAGGGAGAGTAGGAGAGACCATGAGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCC
ACATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGA
GCCATGCATGATTAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCT
AGATCATCATAAGACTACAGAGCACTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCC
CTTAGAGATAGAGAAACAGACCCAAGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATT
TTAAGTTATGTTAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAG
CAGTAGGAGAGATTGGCCCATTTGGTGCTGGCCATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGA
GGAATTGAAGTAAATTTCAGCATTGGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAG
GCAGCGTGCGTGATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAATACTGTTTCTGATAAAAA

>58000_58000_6_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000554143_SPARC_chr5_151049345_ENST00000231061_length(amino acids)=450AA_BP=257
MAELQEVQITEEKPLLPGQTPEAAKTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPG
MEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLTGLTSSIP
EMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLVVGDQAPHEDAVVCSNDNKTFDSSC
HFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPV
ELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIALDEWAGCFGIKQKDIDKDLVI

--------------------------------------------------------------
>58000_58000_7_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000556147_SPARC_chr5_151049345_ENST00000231061_length(transcript)=4811nt_BP=1754nt
GTGATTGATCCGCGTCCCCTGGAGCTGGAGGCTCGGGGGAAAGGGCCAGCACGGAGCGGGCGCTCGGTTGCTGCGCACAAAGGCTGAGGC
TCCAAGAGCTGCAGGGCGTGTTTGGGGTGCGCGCGAGGTTGTGTGCAAGGTCCGGGGCGCTTGGCACCGGCCACGCAAGGGTGTCAGTCT
CCACGCGGACGGGCTGCGTAGGGACTCGTAGGGACGGGTTCCGGGTGCTGGGCCCGGCCGGTCTCCTCTGTCCTACCCATCCCTTCCCGA
TGGCGCTTGCCTTCGCGGGCCGTCGGGGGAGAACGGGAGAAGATTGTGGGACCGCTCTCCTCTCCCTTTCTCCACTCGTGGGACCTACAC
GGAGACTGAGTAGAGGAGAGAAGCGACGGCACCAATCTTTGTGTTTGTTTTTAAATTGTGGAGGGAAACAGCCATGCTCTGCTACCCTCC
TCTTACTGGAGAGCTGTCAAAAATTTTGGGGATCCCCTATTCCCCCGCGTTTAGTCCCCCTGCAGATAGAAAATTGAGGCCAAATGTAGT
AACTAACTGGGGCAAGGTCACACTGGGAGTGGCAGAGCCGGGATTCGAATCCGGAGGTTCTGACAGGGCCACCCTCTTACCTCCACATCA
GCACTTCCTTCTCTCCTCCGCGCAGCCTGAACTGATGCCCTTGTAGCCTATATTGATTCCGGCTCGAGCCTAGAGAGGACGTGTTCTCTG
GACTTAGGGGTAGACAGACACTGGGGAGGGTTAGTGACCCGAGGAGGTTGATGACCCTGGGAGTCTGGGTCTTGGCTGAGGCTTTCCGTC
CCTGAAAGACCCCAGGTCTGTCTCCCATGTCATTCACCTCGTTGCTGTGTTTTCTCAGACCCCAGAGTCAGAAGGAGTGAGAACCCTGAC
CCCTAATCCCACTGCATCCAGCCAATAGGAGCCCAGCCACCATGGCGGAGCTGCAGGAGGTGCAGATCACAGAGGAGAAGCCACTGTTGC
CAGGACAGACGCCTGAGGCGGCCAAGGAGGCTGAGTTAGCTGCCCGAATCCTCCTGGACCAGGGACAGACTCACTCTGTGGAGACACCAT
ACGGCTCTGTCACTTTCACTGTCTATGGCACCCCCAAACCCAAACGCCCAGCGATCCTTACCTACCACGATGTGGGACTCAACTATAAAT
CTTGCTTCCAGCCACTGTTTCAGTTCGAGGACATGCAGGAAATCATTCAGAACTTTGTGCGGGTTCATGTGGATGCCCCTGGAATGGAAG
AGGGAGCCCCTGTGTTCCCTTTGGGATATCAGTACCCATCTCTGGACCAGCTTGCAGACATGATCCCTTGCGTCCTGCAGTACCTAAATT
TCTCTACAATAATTGGAGTTGGTGTTGGAGCTGGAGCCTACATCCTGGCGAGATATGCTCTTAACCACCCGGACACTGTTGAAGGTCTTG
TCCTCATCAACATTGATCCCAATGCCAAGGGTTGGATGGATTGGGCAGCCCACAAGCTAACAGGCCTCACCTCTTCCATTCCGGAGATGA
TCCTTGGACATCTTTTCAGCCAGGAAGAGCTCTCTGGAAATTCTGAGTTGATACAAAAGTACAGAAATATCATTACACATGCACCCAACC
TGGATAACATTGAATTGTACTGGAACAGCTACAACAACCGCCGAGACCTGAACTTTGAGCGTGGAGGTGATATCACCCTCAGGTGTCCTG
TGATGCTGGTGGTAGGAGACCAAGCACCTCATGAAGATGCAGTGGTGTGCAGCAATGACAACAAGACCTTCGACTCTTCCTGCCACTTCT
TTGCCACAAAGTGCACCCTGGAGGGCACCAAGAAGGGCCACAAGCTCCACCTGGACTACATCGGGCCTTGCAAATACATCCCCCCTTGCC
TGGACTCTGAGCTGACCGAATTCCCCCTGCGCATGCGGGACTGGCTCAAGAACGTCCTGGTCACCCTGTATGAGAGGGATGAGGACAACA
ACCTTCTGACTGAGAAGCAGAAGCTGCGGGTGAAGAAGATCCATGAGAATGAGAAGCGCCTGGAGGCAGGAGACCACCCCGTGGAGCTGC
TGGCCCGGGACTTCGAGAAGAACTATAACATGTACATCTTCCCTGTACACTGGCAGTTCGGCCAGCTGGACCAGCACCCCATTGACGGGT
ACCTCTCCCACACCGAGCTGGCTCCACTGCGTGCTCCCCTCATCCCCATGGAGCATTGCACCACCCGCTTTTTCGAGACCTGTGACCTGG
ACAATGACAAGTACATCGCCCTGGATGAGTGGGCCGGCTGCTTCGGCATCAAGCAGAAGGATATCGACAAGGATCTTGTGATCTAAATCC
ACTCCTTCCACAGTACCGGATTCTCTCTTTAACCCTCCCCTTCGTGTTTCCCCCAATGTTTAAAATGTTTGGATGGTTTGTTGTTCTGCC
TGGAGACAAGGTGCTAACATAGATTTAAGTGAATACATTAACGGTGCTAAAAATGAAAATTCTAACCCAAGACATGACATTCTTAGCTGT
AACTTAACTATTAAGGCCTTTTCCACACGCATTAATAGTCCCATTTTTCTCTTGCCATTTGTAGCTTTGCCCATTGTCTTATTGGCACAT
GGGTGGACACGGATCTGCTGGGCTCTGCCTTAAACACACATTGCAGCTTCAACTTTTCTCTTTAGTGTTCTGTTTGAAACTAATACTTAC
CGAGTCAGACTTTGTGTTCATTTCATTTCAGGGTCTTGGCTGCCTGTGGGCTTCCCCAGGTGGCCTGGAGGTGGGCAAAGGGAAGTAACA
GACACACGATGTTGTCAAGGATGGTTTTGGGACTAGAGGCTCAGTGGTGGGAGAGATCCCTGCAGAACCCACCAACCAGAACGTGGTTTG
CCTGAGGCTGTAACTGAGAGAAAGATTCTGGGGCTGTGTTATGAAAATATAGACATTCTCACATAAGCCCAGTTCATCACCATTTCCTCC
TTTACCTTTCAGTGCAGTTTCTTTTCACATTAGGCTGTTGGTTCAAACTTTTGGGAGCACGGACTGTCAGTTCTCTGGGAAGTGGTCAGC
GCATCCTGCAGGGCTTCTCCTCCTCTGTCTTTTGGAGAACCAGGGCTCTTCTCAGGGGCTCTAGGGACTGCCAGGCTGTTTCAGCCAGGA
AGGCCAAAATCAAGAGTGAGATGTAGAAAGTTGTAAAATAGAAAAAGTGGAGTTGGTGAATCGGTTGTTCTTTCCTCACATTTGGATGAT
TGTCATAAGGTTTTTAGCATGTTCCTCCTTTTCTTCACCCTCCCCTTTTTTCTTCTATTAATCAAGAGAAACTTCAAAGTTAATGGGATG
GTCGGATCTCACAGGCTGAGAACTCGTTCACCTCCAAGCATTTCATGAAAAAGCTGCTTCTTATTAATCATACAAACTCTCACCATGATG
TGAAGAGTTTCACAAATCCTTCAAAATAAAAAGTAATGACTTAGAAACTGCCTTCCTGGGTGATTTGCATGTGTCTTAGTCTTAGTCACC
TTATTATCCTGACACAAAAACACATGAGCATACATGTCTACACATGACTACACAAATGCAAACCTTTGCAAACACATTATGCTTTTGCAC
ACACACACCTGTACACACACACCGGCATGTTTATACACAGGGAGTGTATGGTTCCTGTAAGCACTAAGTTAGCTGTTTTCATTTAATGAC
CTGTGGTTTAACCCTTTTGATCACTACCACCATTATCAGCACCAGACTGAGCAGCTATATCCTTTTATTAATCATGGTCATTCATTCATT
CATTCATTCACAAAATATTTATGATGTATTTACTCTGCACCAGGTCCCATGCCAAGCACTGGGGACACAGTTATGGCAAAGTAGACAAAG
CATTTGTTCATTTGGAGCTTAGAGTCCAGGAGGAATACATTAGATAATGACACAATCAAATATAAATTGCAAGATGTCACAGGTGTGATG
AAGGGAGAGTAGGAGAGACCATGAGTATGTGTAACAGGAGGACACAGCATTATTCTAGTGCTGTACTGTTCCGTACGGCAGCCACTACCC
ACATGTAACTTTTTAAGATTTAAATTTAAATTAGTTAACATTCAAAACGCAGCTCCCCAATCACACTAGCAACATTTCAAGTGCTTGAGA
GCCATGCATGATTAGTGGTTACCCTATTGAATAGGTCAGAAGTAGAATCTTTTCATCATCACAGAAAGTTCTATTGGACAGTGCTCTTCT
AGATCATCATAAGACTACAGAGCACTTTTCAAAGCTCATGCATGTTCATCATGTTAGTGTCGTATTTTGAGCTGGGGTTTTGAGACTCCC
CTTAGAGATAGAGAAACAGACCCAAGAAATGTGCTCAATTGCAATGGGCCACATACCTAGATCTCCAGATGTCATTTCCCCTCTCTTATT
TTAAGTTATGTTAAGATTACTAAAACAATAAAAGCTCCTAAAAAATCAAACTGTATTCTGGTGTTCTCTTCTACACAGTGGGAGGGCGAG
CAGTAGGAGAGATTGGCCCATTTGGTGCTGGCCATTTGAGGAATGCAAGCCCAGCACTAGTCTCATAATCTCTAGGAATCTGTAGAGAGA
GGAATTGAAGTAAATTTCAGCATTGGCTCATTCAGTCATTCGGCGACATTCATCAGGTACCTGCAATGTGTTAGGGGATCTTATGAGTAG
GCAGCGTGCGTGATCCTTGCTCCCCTGGAGCTTTCTAACATTCTAGCAGGCAGACCACACATAAATTTGCAATACTGTTTCTGATAAAAA

>58000_58000_7_NDRG2-SPARC_NDRG2_chr14_21486922_ENST00000556147_SPARC_chr5_151049345_ENST00000231061_length(amino acids)=474AA_BP=281
MHPANRSPATMAELQEVQITEEKPLLPGQTPEAAKEAELAARILLDQGQTHSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQ
PLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYPSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLIN
IDPNAKGWMDWAAHKLTGLTSSIPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITLRCPVMLV
VGDQAPHEDAVVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLT
EKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDK

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NDRG2-SPARC

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NDRG2-SPARC

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NDRG2-SPARC

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source