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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDUFA13-GATAD2A (FusionGDB2 ID:58058)

Fusion Gene Summary for NDUFA13-GATAD2A

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFA13-GATAD2A
Fusion gene ID: 58058
HgeneTgene
Gene symbol

NDUFA13

GATAD2A

Gene ID

51079

54815

Gene nameNADH:ubiquinone oxidoreductase subunit A13GATA zinc finger domain containing 2A
SynonymsB16.6|CDA016|CGI-39|GRIM-19|GRIM19|MC1DN28p66alpha
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13CI-B16.6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13NADH-ubiquinone oxidoreductase B16.6 subunitcell death regulatory protein GRIM-19cell death-regulatory protein GRIM19complex Itranscriptional repressor p66-alphaGATA zinc finger domain-containing protein 2A
Modification date2020031320200313
UniProtAcc

Q9P0J0

Q86YP4

Ensembl transtripts involved in fusion geneENST00000252576, ENST00000428459, 
ENST00000503283, ENST00000507754, 
ENST00000512771, 		ENST00000252577, 
ENST00000358713, ENST00000360315, 
ENST00000404158, ENST00000537887, 
ENST00000429563, ENST00000473184, 
Fusion gene scores* DoF score7 X 5 X 5=17511 X 10 X 9=990
# samples 714
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/990*10)=-2.82200169802201
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFA13 [Title/Abstract] AND GATAD2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDUFA13(19627141)-GATAD2A(19576149), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNDUFA13

GO:0030308

negative regulation of cell growth

10924506

HgeneNDUFA13

GO:0035458

cellular response to interferon-beta

17297443

HgeneNDUFA13

GO:0045039

protein import into mitochondrial inner membrane

23271731

HgeneNDUFA13

GO:0045892

negative regulation of transcription, DNA-templated

12867595

HgeneNDUFA13

GO:0071300

cellular response to retinoic acid

17297443

HgeneNDUFA13

GO:0097190

apoptotic signaling pathway

10924506

TgeneGATAD2A

GO:0045892

negative regulation of transcription, DNA-templated

12183469


check buttonFusion gene breakpoints across NDUFA13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GATAD2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-EA-A556-01ANDUFA13chr19

19627141

+GATAD2Achr19

19576149

+


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Fusion Gene ORF analysis for NDUFA13-GATAD2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000252576ENST00000252577NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000252576ENST00000358713NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000252576ENST00000360315NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000252576ENST00000404158NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000252576ENST00000537887NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000428459ENST00000252577NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000428459ENST00000358713NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000428459ENST00000360315NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000428459ENST00000404158NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000428459ENST00000537887NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000503283ENST00000252577NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000503283ENST00000358713NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000503283ENST00000360315NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000503283ENST00000404158NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000503283ENST00000537887NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000507754ENST00000252577NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000507754ENST00000358713NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000507754ENST00000360315NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000507754ENST00000404158NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000507754ENST00000537887NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000512771ENST00000252577NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000512771ENST00000358713NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000512771ENST00000360315NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000512771ENST00000404158NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-5UTRENST00000512771ENST00000537887NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000252576ENST00000429563NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000252576ENST00000473184NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000428459ENST00000429563NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000428459ENST00000473184NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000503283ENST00000429563NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000503283ENST00000473184NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000507754ENST00000429563NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000507754ENST00000473184NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000512771ENST00000429563NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+
5CDS-intronENST00000512771ENST00000473184NDUFA13chr19

19627141

+GATAD2Achr19

19576149

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NDUFA13-GATAD2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NDUFA13chr1919627141+GATAD2Achr1919576153+0.0002588170.99974114
NDUFA13chr1919627141+GATAD2Achr1919576153+0.0002588170.99974114

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NDUFA13-GATAD2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:19627141/:19576149)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDUFA13

Q9P0J0

GATAD2A

Q86YP4

FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091, ECO:0000269|PubMed:27626371}.FUNCTION: Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B. {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NDUFA13-GATAD2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NDUFA13-GATAD2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDUFA13-GATAD2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDUFA13-GATAD2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource