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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDUFA13-SUGP1 (FusionGDB2 ID:58062)

Fusion Gene Summary for NDUFA13-SUGP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFA13-SUGP1
Fusion gene ID: 58062
HgeneTgene
Gene symbol

NDUFA13

SUGP1

Gene ID

51079

57794

Gene nameNADH:ubiquinone oxidoreductase subunit A13SURP and G-patch domain containing 1
SynonymsB16.6|CDA016|CGI-39|GRIM-19|GRIM19|MC1DN28F23858|RBP|SF4
Cytomap

19p13.11

19p13.11

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13CI-B16.6NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13NADH-ubiquinone oxidoreductase B16.6 subunitcell death regulatory protein GRIM-19cell death-regulatory protein GRIM19complex ISURP and G-patch domain-containing protein 1RNA-binding protein RBPsplicing factor 4
Modification date2020031320200313
UniProtAcc

Q9P0J0

.
Ensembl transtripts involved in fusion geneENST00000252576, ENST00000428459, 
ENST00000503283, ENST00000507754, 
ENST00000512771, 
ENST00000334782, 
ENST00000585763, ENST00000247001, 
Fusion gene scores* DoF score7 X 5 X 5=1755 X 4 X 2=40
# samples 75
** MAII scorelog2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NDUFA13 [Title/Abstract] AND SUGP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDUFA13(19627141)-SUGP1(19391100), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNDUFA13

GO:0030308

negative regulation of cell growth

10924506

HgeneNDUFA13

GO:0035458

cellular response to interferon-beta

17297443

HgeneNDUFA13

GO:0045039

protein import into mitochondrial inner membrane

23271731

HgeneNDUFA13

GO:0045892

negative regulation of transcription, DNA-templated

12867595

HgeneNDUFA13

GO:0071300

cellular response to retinoic acid

17297443

HgeneNDUFA13

GO:0097190

apoptotic signaling pathway

10924506


check buttonFusion gene breakpoints across NDUFA13 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUGP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3TW-01ANDUFA13chr19

19627141

+SUGP1chr19

19391100

-
ChimerDB4UCECTCGA-AJ-A3TWNDUFA13chr19

19627141

+SUGP1chr19

19391100

-


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Fusion Gene ORF analysis for NDUFA13-SUGP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000252576ENST00000334782NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000252576ENST00000585763NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000428459ENST00000334782NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000428459ENST00000585763NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000503283ENST00000334782NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000503283ENST00000585763NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000507754ENST00000334782NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000507754ENST00000585763NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000512771ENST00000334782NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
5CDS-intronENST00000512771ENST00000585763NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
In-frameENST00000252576ENST00000247001NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
In-frameENST00000428459ENST00000247001NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
In-frameENST00000503283ENST00000247001NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
In-frameENST00000507754ENST00000247001NDUFA13chr19

19627141

+SUGP1chr19

19391100

-
In-frameENST00000512771ENST00000247001NDUFA13chr19

19627141

+SUGP1chr19

19391100

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000507754NDUFA13chr1919627141+ENST00000247001SUGP1chr1919391100-14105782351272345
ENST00000252576NDUFA13chr1919627141+ENST00000247001SUGP1chr1919391100-117534301037345
ENST00000503283NDUFA13chr1919627141+ENST00000247001SUGP1chr1919391100-93710511799262
ENST00000512771NDUFA13chr1919627141+ENST00000247001SUGP1chr1919391100-93610410798262
ENST00000428459NDUFA13chr1919627141+ENST00000247001SUGP1chr1919391100-9351039797262

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000507754ENST00000247001NDUFA13chr1919627141+SUGP1chr1919391100-0.0080822460.9919178
ENST00000252576ENST00000247001NDUFA13chr1919627141+SUGP1chr1919391100-0.0054260580.994574
ENST00000503283ENST00000247001NDUFA13chr1919627141+SUGP1chr1919391100-0.0026093070.9973907
ENST00000512771ENST00000247001NDUFA13chr1919627141+SUGP1chr1919391100-0.0027800830.9972199
ENST00000428459ENST00000247001NDUFA13chr1919627141+SUGP1chr1919391100-0.0027193120.9972807

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Fusion Genomic Features for NDUFA13-SUGP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDUFA13-SUGP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:19627141/chr19:19391100)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NDUFA13

Q9P0J0

.
FUNCTION: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371). Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371). Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes (PubMed:15753091). {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091, ECO:0000269|PubMed:27626371}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSUGP1chr19:19627141chr19:19391100ENST00000247001714441_480414646.0Compositional biasNote=Gln/Met-rich
TgeneSUGP1chr19:19627141chr19:19391100ENST0000033478205330_3730223.0Compositional biasNote=Pro-rich
TgeneSUGP1chr19:19627141chr19:19391100ENST0000033478205441_4800223.0Compositional biasNote=Gln/Met-rich
TgeneSUGP1chr19:19627141chr19:19391100ENST00000247001714562_609414646.0DomainG-patch
TgeneSUGP1chr19:19627141chr19:19391100ENST0000033478205562_6090223.0DomainG-patch
TgeneSUGP1chr19:19627141chr19:19391100ENST0000033478205380_3860223.0MotifNuclear localization signal
TgeneSUGP1chr19:19627141chr19:19391100ENST0000033478205191_2330223.0RepeatNote=SURP motif 1
TgeneSUGP1chr19:19627141chr19:19391100ENST0000033478205266_3090223.0RepeatNote=SURP motif 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDUFA13chr19:19627141chr19:19391100ENST00000507754+15102_14431145.0RegionNote=Important for inducing cell death
HgeneNDUFA13chr19:19627141chr19:19391100ENST00000507754+1530_5131145.0TransmembraneHelical
TgeneSUGP1chr19:19627141chr19:19391100ENST00000247001714330_373414646.0Compositional biasNote=Pro-rich
TgeneSUGP1chr19:19627141chr19:19391100ENST00000247001714380_386414646.0MotifNuclear localization signal
TgeneSUGP1chr19:19627141chr19:19391100ENST00000247001714191_233414646.0RepeatNote=SURP motif 1
TgeneSUGP1chr19:19627141chr19:19391100ENST00000247001714266_309414646.0RepeatNote=SURP motif 2


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Fusion Gene Sequence for NDUFA13-SUGP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58062_58062_1_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000252576_SUGP1_chr19_19391100_ENST00000247001_length(transcript)=1175nt_BP=343nt
ATGCAAGAACCAAGGCGAGTCACGCCCTGTCTGGGCAAAAGAGGAGTAAAGACCCCTCAGCTGCAGCCCGGCAGCGCATTCCTACCCAGG
GTCCGCCGCCAGAGCTTTCCCGCGCGGTCGGATAGTTACACTACTGTCCGGGACTTCCTAGCCGTGCCGCGGACCATCTCAAGTGCTTCC
GCCACACTCATCATGGCGGTGGCAGTAAGTCACTTCCGCCCGGGACCGGAAGTGTGGGATACTGCGAGTATGGCGGCGTCAAAGGTGAAG
CAGGACATGCCTCCGCCGGGGGGCTATGGGCCCATCGACTACAAACGGAACTTGCCGCGTCGAGGACTGTCGGTTCAGGACCTCAAGGGG
CTCGGCTATGAGAAGGGGAAGCCTGTGGGTCTAGTGGGCGTCACAGAGCTTTCAGACGCCCAGAAGAAGCAGCTGAAGGAGCAGCAGGAG
ATGCAGCAGATGTACGACATGATCATGCAGCACAAGCGGGCCATGCAGGACATGCAGCTGCTGTGGGAGAAGGCAGTCCAACAGCACCAG
CACGGCTATGACAGTGATGAGGAGGTGGACAGCGAGCTGGGCACCTGGGAGCACCAGCTGCGGCGCATGGAGATGGATAAGACCAGGGAA
TGGGCCGAGCAGCTGACAAAGATGGGCCGGGGCAAGCACTTCATCGGAGACTTCCTGCCTCCAGACGAGCTGGAAAAGTTTATGGAGACC
TTCAAGGCCCTGAAGGAGGGCCGTGAGCCTGACTACTCAGAGTACAAGGAGTTCAAGCTGACTGTGGAGAACATCGGCTACCAGATGCTG
ATGAAGATGGGCTGGAAGGAGGGCGAGGGGCTGGGCTCAGAGGGCCAGGGCATCAAGAACCCAGTGAACAAGGGCACCACCACAGTGGAC
GGCGCTGGCTTCGGCATTGACCGGCCGGCGGAGCTCTCCAAGGAGGACGACGAGTATGAGGCGTTCCGCAAGAGGATGATGCTGGCCTAC
CGCTTCCGGCCCAACCCCCTGAACAATCCCAGACGGCCTTACTACTGAGTGTTCTGGAAATACATACTTTCTGAATGACCAACCGTCCCT
GGACTGTGGAATGTTCCGGCCTGCATTTCTGCCCACCCCTTCCGTTGTCACGAGTGCCGTGCCGTGTAATAAAGTCCCAGTGCTCATCCA

>58062_58062_1_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000252576_SUGP1_chr19_19391100_ENST00000247001_length(amino acids)=345AA_BP=114
MQEPRRVTPCLGKRGVKTPQLQPGSAFLPRVRRQSFPARSDSYTTVRDFLAVPRTISSASATLIMAVAVSHFRPGPEVWDTASMAASKVK
QDMPPPGGYGPIDYKRNLPRRGLSVQDLKGLGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWEKAVQQHQ
HGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTKMGRGKHFIGDFLPPDELEKFMETFKALKEGREPDYSEYKEFKLTVENIGYQML

--------------------------------------------------------------
>58062_58062_2_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000428459_SUGP1_chr19_19391100_ENST00000247001_length(transcript)=935nt_BP=103nt
ACTGCGAGTATGGCGGCGTCAAAGGTGAAGCAGGACATGCCTCCGCCGGGGGGCTATGGGCCCATCGACTACAAACGGAACTTGCCGCGT
CGAGGACTGTCGGTTCAGGACCTCAAGGGGCTCGGCTATGAGAAGGGGAAGCCTGTGGGTCTAGTGGGCGTCACAGAGCTTTCAGACGCC
CAGAAGAAGCAGCTGAAGGAGCAGCAGGAGATGCAGCAGATGTACGACATGATCATGCAGCACAAGCGGGCCATGCAGGACATGCAGCTG
CTGTGGGAGAAGGCAGTCCAACAGCACCAGCACGGCTATGACAGTGATGAGGAGGTGGACAGCGAGCTGGGCACCTGGGAGCACCAGCTG
CGGCGCATGGAGATGGATAAGACCAGGGAATGGGCCGAGCAGCTGACAAAGATGGGCCGGGGCAAGCACTTCATCGGAGACTTCCTGCCT
CCAGACGAGCTGGAAAAGTTTATGGAGACCTTCAAGGCCCTGAAGGAGGGCCGTGAGCCTGACTACTCAGAGTACAAGGAGTTCAAGCTG
ACTGTGGAGAACATCGGCTACCAGATGCTGATGAAGATGGGCTGGAAGGAGGGCGAGGGGCTGGGCTCAGAGGGCCAGGGCATCAAGAAC
CCAGTGAACAAGGGCACCACCACAGTGGACGGCGCTGGCTTCGGCATTGACCGGCCGGCGGAGCTCTCCAAGGAGGACGACGAGTATGAG
GCGTTCCGCAAGAGGATGATGCTGGCCTACCGCTTCCGGCCCAACCCCCTGAACAATCCCAGACGGCCTTACTACTGAGTGTTCTGGAAA
TACATACTTTCTGAATGACCAACCGTCCCTGGACTGTGGAATGTTCCGGCCTGCATTTCTGCCCACCCCTTCCGTTGTCACGAGTGCCGT

>58062_58062_2_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000428459_SUGP1_chr19_19391100_ENST00000247001_length(amino acids)=262AA_BP=31
MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSVQDLKGLGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWE
KAVQQHQHGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTKMGRGKHFIGDFLPPDELEKFMETFKALKEGREPDYSEYKEFKLTVE

--------------------------------------------------------------
>58062_58062_3_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000503283_SUGP1_chr19_19391100_ENST00000247001_length(transcript)=937nt_BP=105nt
ATACTGCGAGTATGGCGGCGTCAAAGGTGAAGCAGGACATGCCTCCGCCGGGGGGCTATGGGCCCATCGACTACAAACGGAACTTGCCGC
GTCGAGGACTGTCGGTTCAGGACCTCAAGGGGCTCGGCTATGAGAAGGGGAAGCCTGTGGGTCTAGTGGGCGTCACAGAGCTTTCAGACG
CCCAGAAGAAGCAGCTGAAGGAGCAGCAGGAGATGCAGCAGATGTACGACATGATCATGCAGCACAAGCGGGCCATGCAGGACATGCAGC
TGCTGTGGGAGAAGGCAGTCCAACAGCACCAGCACGGCTATGACAGTGATGAGGAGGTGGACAGCGAGCTGGGCACCTGGGAGCACCAGC
TGCGGCGCATGGAGATGGATAAGACCAGGGAATGGGCCGAGCAGCTGACAAAGATGGGCCGGGGCAAGCACTTCATCGGAGACTTCCTGC
CTCCAGACGAGCTGGAAAAGTTTATGGAGACCTTCAAGGCCCTGAAGGAGGGCCGTGAGCCTGACTACTCAGAGTACAAGGAGTTCAAGC
TGACTGTGGAGAACATCGGCTACCAGATGCTGATGAAGATGGGCTGGAAGGAGGGCGAGGGGCTGGGCTCAGAGGGCCAGGGCATCAAGA
ACCCAGTGAACAAGGGCACCACCACAGTGGACGGCGCTGGCTTCGGCATTGACCGGCCGGCGGAGCTCTCCAAGGAGGACGACGAGTATG
AGGCGTTCCGCAAGAGGATGATGCTGGCCTACCGCTTCCGGCCCAACCCCCTGAACAATCCCAGACGGCCTTACTACTGAGTGTTCTGGA
AATACATACTTTCTGAATGACCAACCGTCCCTGGACTGTGGAATGTTCCGGCCTGCATTTCTGCCCACCCCTTCCGTTGTCACGAGTGCC

>58062_58062_3_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000503283_SUGP1_chr19_19391100_ENST00000247001_length(amino acids)=262AA_BP=31
MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSVQDLKGLGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWE
KAVQQHQHGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTKMGRGKHFIGDFLPPDELEKFMETFKALKEGREPDYSEYKEFKLTVE

--------------------------------------------------------------
>58062_58062_4_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000507754_SUGP1_chr19_19391100_ENST00000247001_length(transcript)=1410nt_BP=578nt
GGGAGCAGAATCCGTTCCAGGGATTGGGGTGAGTCCGACTTCGAGCAGCAGCTGCCCCCCAACATCATGTACCCAGCCCGTGACTACGTG
GAGCCCTGGGCTTCGCGTAGAGTCCCTAGACGGGGCGAAAACGGGAAAAGGGGCCTTAACTGGGGCACCTGGCTCCTTTGAGAGCTCGGA
GTTTCTGACTGGCCTGCGCAACACCCCAGAGGCAAGGTGAACGCGAGGGCCTATAATGCAAGAACCAAGGCGAGTCACGCCCTGTCTGGG
CAAAAGAGGAGTAAAGACCCCTCAGCTGCAGCCCGGCAGCGCATTCCTACCCAGGGTCCGCCGCCAGAGCTTTCCCGCGCGGTCGGATAG
TTACACTACTGTCCGGGACTTCCTAGCCGTGCCGCGGACCATCTCAAGTGCTTCCGCCACACTCATCATGGCGGTGGCAGTAAGTCACTT
CCGCCCGGGACCGGAAGTGTGGGATACTGCGAGTATGGCGGCGTCAAAGGTGAAGCAGGACATGCCTCCGCCGGGGGGCTATGGGCCCAT
CGACTACAAACGGAACTTGCCGCGTCGAGGACTGTCGGTTCAGGACCTCAAGGGGCTCGGCTATGAGAAGGGGAAGCCTGTGGGTCTAGT
GGGCGTCACAGAGCTTTCAGACGCCCAGAAGAAGCAGCTGAAGGAGCAGCAGGAGATGCAGCAGATGTACGACATGATCATGCAGCACAA
GCGGGCCATGCAGGACATGCAGCTGCTGTGGGAGAAGGCAGTCCAACAGCACCAGCACGGCTATGACAGTGATGAGGAGGTGGACAGCGA
GCTGGGCACCTGGGAGCACCAGCTGCGGCGCATGGAGATGGATAAGACCAGGGAATGGGCCGAGCAGCTGACAAAGATGGGCCGGGGCAA
GCACTTCATCGGAGACTTCCTGCCTCCAGACGAGCTGGAAAAGTTTATGGAGACCTTCAAGGCCCTGAAGGAGGGCCGTGAGCCTGACTA
CTCAGAGTACAAGGAGTTCAAGCTGACTGTGGAGAACATCGGCTACCAGATGCTGATGAAGATGGGCTGGAAGGAGGGCGAGGGGCTGGG
CTCAGAGGGCCAGGGCATCAAGAACCCAGTGAACAAGGGCACCACCACAGTGGACGGCGCTGGCTTCGGCATTGACCGGCCGGCGGAGCT
CTCCAAGGAGGACGACGAGTATGAGGCGTTCCGCAAGAGGATGATGCTGGCCTACCGCTTCCGGCCCAACCCCCTGAACAATCCCAGACG
GCCTTACTACTGAGTGTTCTGGAAATACATACTTTCTGAATGACCAACCGTCCCTGGACTGTGGAATGTTCCGGCCTGCATTTCTGCCCA

>58062_58062_4_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000507754_SUGP1_chr19_19391100_ENST00000247001_length(amino acids)=345AA_BP=114
MQEPRRVTPCLGKRGVKTPQLQPGSAFLPRVRRQSFPARSDSYTTVRDFLAVPRTISSASATLIMAVAVSHFRPGPEVWDTASMAASKVK
QDMPPPGGYGPIDYKRNLPRRGLSVQDLKGLGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWEKAVQQHQ
HGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTKMGRGKHFIGDFLPPDELEKFMETFKALKEGREPDYSEYKEFKLTVENIGYQML

--------------------------------------------------------------
>58062_58062_5_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000512771_SUGP1_chr19_19391100_ENST00000247001_length(transcript)=936nt_BP=104nt
TACTGCGAGTATGGCGGCGTCAAAGGTGAAGCAGGACATGCCTCCGCCGGGGGGCTATGGGCCCATCGACTACAAACGGAACTTGCCGCG
TCGAGGACTGTCGGTTCAGGACCTCAAGGGGCTCGGCTATGAGAAGGGGAAGCCTGTGGGTCTAGTGGGCGTCACAGAGCTTTCAGACGC
CCAGAAGAAGCAGCTGAAGGAGCAGCAGGAGATGCAGCAGATGTACGACATGATCATGCAGCACAAGCGGGCCATGCAGGACATGCAGCT
GCTGTGGGAGAAGGCAGTCCAACAGCACCAGCACGGCTATGACAGTGATGAGGAGGTGGACAGCGAGCTGGGCACCTGGGAGCACCAGCT
GCGGCGCATGGAGATGGATAAGACCAGGGAATGGGCCGAGCAGCTGACAAAGATGGGCCGGGGCAAGCACTTCATCGGAGACTTCCTGCC
TCCAGACGAGCTGGAAAAGTTTATGGAGACCTTCAAGGCCCTGAAGGAGGGCCGTGAGCCTGACTACTCAGAGTACAAGGAGTTCAAGCT
GACTGTGGAGAACATCGGCTACCAGATGCTGATGAAGATGGGCTGGAAGGAGGGCGAGGGGCTGGGCTCAGAGGGCCAGGGCATCAAGAA
CCCAGTGAACAAGGGCACCACCACAGTGGACGGCGCTGGCTTCGGCATTGACCGGCCGGCGGAGCTCTCCAAGGAGGACGACGAGTATGA
GGCGTTCCGCAAGAGGATGATGCTGGCCTACCGCTTCCGGCCCAACCCCCTGAACAATCCCAGACGGCCTTACTACTGAGTGTTCTGGAA
ATACATACTTTCTGAATGACCAACCGTCCCTGGACTGTGGAATGTTCCGGCCTGCATTTCTGCCCACCCCTTCCGTTGTCACGAGTGCCG

>58062_58062_5_NDUFA13-SUGP1_NDUFA13_chr19_19627141_ENST00000512771_SUGP1_chr19_19391100_ENST00000247001_length(amino acids)=262AA_BP=31
MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSVQDLKGLGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWE
KAVQQHQHGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTKMGRGKHFIGDFLPPDELEKFMETFKALKEGREPDYSEYKEFKLTVE

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Fusion Gene PPI Analysis for NDUFA13-SUGP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDUFA13-SUGP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDUFA13-SUGP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource