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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDUFB2-KLC1 (FusionGDB2 ID:58167)

Fusion Gene Summary for NDUFB2-KLC1

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFB2-KLC1
Fusion gene ID: 58167
HgeneTgene
Gene symbol

NDUFB2

KLC1

Gene ID

4708

3831

Gene nameNADH:ubiquinone oxidoreductase subunit B2kinesin light chain 1
SynonymsAGGG|CI-AGGGKLC|KNS2|KNS2A
Cytomap

7q34

14q32.33

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrialNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDaNADH-ubiquinone oxidoreductase AGGG subunitcomplex I AGGG subunitcomplex I-AGGGkinesin light chain 1kinesin 2 60/70kDamedulloblastoma antigen MU-MB-2.50
Modification date2020031320200313
UniProtAcc.

Q07866

Ensembl transtripts involved in fusion geneENST00000464564, ENST00000247866, 
ENST00000461457, ENST00000465506, 
ENST00000476279, ENST00000204307, 
ENST00000460088, ENST00000471136, 
ENST00000472695, ENST00000475276, 
ENST00000476470, ENST00000482954, 
ENST00000348520, ENST00000246489, 
ENST00000334553, ENST00000347839, 
ENST00000380038, ENST00000389744, 
ENST00000445352, ENST00000452929, 
ENST00000553286, ENST00000554280, 
ENST00000555836, ENST00000557450, 
ENST00000557575, 
Fusion gene scores* DoF score4 X 3 X 2=2420 X 16 X 10=3200
# samples 422
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(22/3200*10)=-3.86249647625007
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFB2 [Title/Abstract] AND KLC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDUFB2(140396642)-KLC1(104166992), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NDUFB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KLC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8527-01ANDUFB2chr7

140396642

+KLC1chr14

104166992

+


Top

Fusion Gene ORF analysis for NDUFB2-KLC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000464564ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
3UTR-intronENST00000464564ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000247866ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000461457ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000465506ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5CDS-intronENST00000476279ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-3CDSENST00000204307ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
5UTR-intronENST00000204307ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
In-frameENST00000247866ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
In-frameENST00000461457ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
In-frameENST00000465506ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
In-frameENST00000476279ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-3CDSENST00000460088ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-3CDSENST00000471136ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-3CDSENST00000472695ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-3CDSENST00000475276ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-3CDSENST00000476470ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-3CDSENST00000482954ENST00000348520NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000460088ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000471136ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000472695ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000475276ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000476470ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000246489NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000334553NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000347839NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000380038NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000389744NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000445352NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000452929NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000553286NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000554280NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000555836NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000557450NDUFB2chr7

140396642

+KLC1chr14

104166992

+
intron-intronENST00000482954ENST00000557575NDUFB2chr7

140396642

+KLC1chr14

104166992

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000476279NDUFB2chr7140396642+ENST00000348520KLC1chr14104166992+5961723222107
ENST00000247866NDUFB2chr7140396642+ENST00000348520KLC1chr14104166992+5951713211107
ENST00000461457NDUFB2chr7140396642+ENST00000348520KLC1chr14104166992+5791553050102
ENST00000465506NDUFB2chr7140396642+ENST00000348520KLC1chr14104166992+5771533031101

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000476279ENST00000348520NDUFB2chr7140396642+KLC1chr14104166992+0.82591540.17408463
ENST00000247866ENST00000348520NDUFB2chr7140396642+KLC1chr14104166992+0.821574330.17842573
ENST00000461457ENST00000348520NDUFB2chr7140396642+KLC1chr14104166992+0.82638190.17361805
ENST00000465506ENST00000348520NDUFB2chr7140396642+KLC1chr14104166992+0.819006260.18099374

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Fusion Genomic Features for NDUFB2-KLC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NDUFB2chr7140396642+KLC1chr14104166991+1.27E-050.99998724
NDUFB2chr7140396642+KLC1chr14104166991+1.27E-050.99998724

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NDUFB2-KLC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140396642/chr14:104166992)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KLC1

Q07866

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLC1chr7:140396642chr14:104166992ENST0000024648901627_1560638.0Coiled coil.
TgeneKLC1chr7:140396642chr14:104166992ENST0000034783901627_1560629.0Coiled coil.
TgeneKLC1chr7:140396642chr14:104166992ENST0000038974401527_1560898.3333333333334Coiled coil.
TgeneKLC1chr7:140396642chr14:104166992ENST0000055328601427_1560561.0Coiled coil.
TgeneKLC1chr7:140396642chr14:104166992ENST00000246489016213_2460638.0RepeatNote=TPR 1
TgeneKLC1chr7:140396642chr14:104166992ENST00000246489016255_2880638.0RepeatNote=TPR 2
TgeneKLC1chr7:140396642chr14:104166992ENST00000246489016297_3300638.0RepeatNote=TPR 3
TgeneKLC1chr7:140396642chr14:104166992ENST00000246489016339_3720638.0RepeatNote=TPR 4
TgeneKLC1chr7:140396642chr14:104166992ENST00000246489016381_4140638.0RepeatNote=TPR 5
TgeneKLC1chr7:140396642chr14:104166992ENST00000246489016464_4970638.0RepeatNote=TPR 6
TgeneKLC1chr7:140396642chr14:104166992ENST00000347839016213_2460629.0RepeatNote=TPR 1
TgeneKLC1chr7:140396642chr14:104166992ENST00000347839016255_2880629.0RepeatNote=TPR 2
TgeneKLC1chr7:140396642chr14:104166992ENST00000347839016297_3300629.0RepeatNote=TPR 3
TgeneKLC1chr7:140396642chr14:104166992ENST00000347839016339_3720629.0RepeatNote=TPR 4
TgeneKLC1chr7:140396642chr14:104166992ENST00000347839016381_4140629.0RepeatNote=TPR 5
TgeneKLC1chr7:140396642chr14:104166992ENST00000347839016464_4970629.0RepeatNote=TPR 6
TgeneKLC1chr7:140396642chr14:104166992ENST00000389744015213_2460898.3333333333334RepeatNote=TPR 1
TgeneKLC1chr7:140396642chr14:104166992ENST00000389744015255_2880898.3333333333334RepeatNote=TPR 2
TgeneKLC1chr7:140396642chr14:104166992ENST00000389744015297_3300898.3333333333334RepeatNote=TPR 3
TgeneKLC1chr7:140396642chr14:104166992ENST00000389744015339_3720898.3333333333334RepeatNote=TPR 4
TgeneKLC1chr7:140396642chr14:104166992ENST00000389744015381_4140898.3333333333334RepeatNote=TPR 5
TgeneKLC1chr7:140396642chr14:104166992ENST00000389744015464_4970898.3333333333334RepeatNote=TPR 6
TgeneKLC1chr7:140396642chr14:104166992ENST00000553286014213_2460561.0RepeatNote=TPR 1
TgeneKLC1chr7:140396642chr14:104166992ENST00000553286014255_2880561.0RepeatNote=TPR 2
TgeneKLC1chr7:140396642chr14:104166992ENST00000553286014297_3300561.0RepeatNote=TPR 3
TgeneKLC1chr7:140396642chr14:104166992ENST00000553286014339_3720561.0RepeatNote=TPR 4
TgeneKLC1chr7:140396642chr14:104166992ENST00000553286014381_4140561.0RepeatNote=TPR 5
TgeneKLC1chr7:140396642chr14:104166992ENST00000553286014464_4970561.0RepeatNote=TPR 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLC1chr7:140396642chr14:104166992ENST00000334553141727_156616668.6666666666666Coiled coil.
TgeneKLC1chr7:140396642chr14:104166992ENST00000348520121527_156550585.0Coiled coil.
TgeneKLC1chr7:140396642chr14:104166992ENST00000452929131627_156593619.0Coiled coil.
TgeneKLC1chr7:140396642chr14:104166992ENST00000557450121527_156541585.0Coiled coil.
TgeneKLC1chr7:140396642chr14:104166992ENST000003345531417213_246616668.6666666666666RepeatNote=TPR 1
TgeneKLC1chr7:140396642chr14:104166992ENST000003345531417255_288616668.6666666666666RepeatNote=TPR 2
TgeneKLC1chr7:140396642chr14:104166992ENST000003345531417297_330616668.6666666666666RepeatNote=TPR 3
TgeneKLC1chr7:140396642chr14:104166992ENST000003345531417339_372616668.6666666666666RepeatNote=TPR 4
TgeneKLC1chr7:140396642chr14:104166992ENST000003345531417381_414616668.6666666666666RepeatNote=TPR 5
TgeneKLC1chr7:140396642chr14:104166992ENST000003345531417464_497616668.6666666666666RepeatNote=TPR 6
TgeneKLC1chr7:140396642chr14:104166992ENST000003485201215213_246550585.0RepeatNote=TPR 1
TgeneKLC1chr7:140396642chr14:104166992ENST000003485201215255_288550585.0RepeatNote=TPR 2
TgeneKLC1chr7:140396642chr14:104166992ENST000003485201215297_330550585.0RepeatNote=TPR 3
TgeneKLC1chr7:140396642chr14:104166992ENST000003485201215339_372550585.0RepeatNote=TPR 4
TgeneKLC1chr7:140396642chr14:104166992ENST000003485201215381_414550585.0RepeatNote=TPR 5
TgeneKLC1chr7:140396642chr14:104166992ENST000003485201215464_497550585.0RepeatNote=TPR 6
TgeneKLC1chr7:140396642chr14:104166992ENST000004529291316213_246593619.0RepeatNote=TPR 1
TgeneKLC1chr7:140396642chr14:104166992ENST000004529291316255_288593619.0RepeatNote=TPR 2
TgeneKLC1chr7:140396642chr14:104166992ENST000004529291316297_330593619.0RepeatNote=TPR 3
TgeneKLC1chr7:140396642chr14:104166992ENST000004529291316339_372593619.0RepeatNote=TPR 4
TgeneKLC1chr7:140396642chr14:104166992ENST000004529291316381_414593619.0RepeatNote=TPR 5
TgeneKLC1chr7:140396642chr14:104166992ENST000004529291316464_497593619.0RepeatNote=TPR 6
TgeneKLC1chr7:140396642chr14:104166992ENST000005574501215213_246541585.0RepeatNote=TPR 1
TgeneKLC1chr7:140396642chr14:104166992ENST000005574501215255_288541585.0RepeatNote=TPR 2
TgeneKLC1chr7:140396642chr14:104166992ENST000005574501215297_330541585.0RepeatNote=TPR 3
TgeneKLC1chr7:140396642chr14:104166992ENST000005574501215339_372541585.0RepeatNote=TPR 4
TgeneKLC1chr7:140396642chr14:104166992ENST000005574501215381_414541585.0RepeatNote=TPR 5
TgeneKLC1chr7:140396642chr14:104166992ENST000005574501215464_497541585.0RepeatNote=TPR 6


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Fusion Gene Sequence for NDUFB2-KLC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58167_58167_1_NDUFB2-KLC1_NDUFB2_chr7_140396642_ENST00000247866_KLC1_chr14_104166992_ENST00000348520_length(transcript)=595nt_BP=171nt
CGGGCGGAGCGCCGGGGAAGCGAAGTAGGCAGGGGCGAGGCGGCTGGGGACCGCGGGGCGGACGGGAGCGAGTATGTCCGCTCTGACTCG
GCTGGCGTCTTTCGCTCGCGTTGGAGGCCGCCTTTTCAGAAGCGGCTGCGCACGGACTGCTGGAGATGGTGGAGTCCGTCAGGCGTCTCT
GGCCGAGCCTCTTTTTGTGGAAAACGACAGCAGCAGCAGTGGCCTGGAAGACGCCACCGCTAACTGACCCCGACCTGGCCCCGCTCCAGG
ATGGGACTGCCGAGTGTGGCCCGGAGCTGGCCCGGGACAGCCAGGGCGGCAGGGAGGGCCCCTGGCCGGGAGCCGCAGCGCTCACTCATT
TCTCCTGCGTCTGTGTGCATAGGACATGATACTAATAACCACACGGCTGGCGTGACCTTGGGGCTGGGGCTGGGCCTAAGCTGGTGCCCT
GGTGCGGCGTGGTCTCTCCCAGGAGACCTGGGGCATGAGCTGGGCCCACGGCTCCCTTCCCATGTGTAACTTCCTCACGTTGTGTGCGAT

>58167_58167_1_NDUFB2-KLC1_NDUFB2_chr7_140396642_ENST00000247866_KLC1_chr14_104166992_ENST00000348520_length(amino acids)=107AA_BP=1
MPPWLSRASSGPHSAVPSWSGARSGSVSGGVFQATAAAVVFHKKRLGQRRLTDSTISSSPCAAASEKAASNASERRQPSQSGHTRSRPPR

--------------------------------------------------------------
>58167_58167_2_NDUFB2-KLC1_NDUFB2_chr7_140396642_ENST00000461457_KLC1_chr14_104166992_ENST00000348520_length(transcript)=579nt_BP=155nt
GAAGCGAAGTAGGCAGGGGCGAGGCGGCTGGGGACCGCGGGGCGGACGGGAGCGAGTATGTCCGCTCTGACTCGGCTGGCGTCTTTCGCT
CGCGTTGGAGGCCGCCTTTTCAGAAGCGGCTGCGCACGGACTGCTGGAGATGGTGGAGTCCGTCAGGCGTCTCTGGCCGAGCCTCTTTTT
GTGGAAAACGACAGCAGCAGCAGTGGCCTGGAAGACGCCACCGCTAACTGACCCCGACCTGGCCCCGCTCCAGGATGGGACTGCCGAGTG
TGGCCCGGAGCTGGCCCGGGACAGCCAGGGCGGCAGGGAGGGCCCCTGGCCGGGAGCCGCAGCGCTCACTCATTTCTCCTGCGTCTGTGT
GCATAGGACATGATACTAATAACCACACGGCTGGCGTGACCTTGGGGCTGGGGCTGGGCCTAAGCTGGTGCCCTGGTGCGGCGTGGTCTC
TCCCAGGAGACCTGGGGCATGAGCTGGGCCCACGGCTCCCTTCCCATGTGTAACTTCCTCACGTTGTGTGCGATAACGTATTTTATTGTA

>58167_58167_2_NDUFB2-KLC1_NDUFB2_chr7_140396642_ENST00000461457_KLC1_chr14_104166992_ENST00000348520_length(amino acids)=102AA_BP=1
MPPWLSRASSGPHSAVPSWSGARSGSVSGGVFQATAAAVVFHKKRLGQRRLTDSTISSSPCAAASEKAASNASERRQPSQSGHTRSRPPR

--------------------------------------------------------------
>58167_58167_3_NDUFB2-KLC1_NDUFB2_chr7_140396642_ENST00000465506_KLC1_chr14_104166992_ENST00000348520_length(transcript)=577nt_BP=153nt
AGCGAAGTAGGCAGGGGCGAGGCGGCTGGGGACCGCGGGGCGGACGGGAGCGAGTATGTCCGCTCTGACTCGGCTGGCGTCTTTCGCTCG
CGTTGGAGGCCGCCTTTTCAGAAGCGGCTGCGCACGGACTGCTGGAGATGGTGGAGTCCGTCAGGCGTCTCTGGCCGAGCCTCTTTTTGT
GGAAAACGACAGCAGCAGCAGTGGCCTGGAAGACGCCACCGCTAACTGACCCCGACCTGGCCCCGCTCCAGGATGGGACTGCCGAGTGTG
GCCCGGAGCTGGCCCGGGACAGCCAGGGCGGCAGGGAGGGCCCCTGGCCGGGAGCCGCAGCGCTCACTCATTTCTCCTGCGTCTGTGTGC
ATAGGACATGATACTAATAACCACACGGCTGGCGTGACCTTGGGGCTGGGGCTGGGCCTAAGCTGGTGCCCTGGTGCGGCGTGGTCTCTC
CCAGGAGACCTGGGGCATGAGCTGGGCCCACGGCTCCCTTCCCATGTGTAACTTCCTCACGTTGTGTGCGATAACGTATTTTATTGTACA

>58167_58167_3_NDUFB2-KLC1_NDUFB2_chr7_140396642_ENST00000465506_KLC1_chr14_104166992_ENST00000348520_length(amino acids)=101AA_BP=1
MPPWLSRASSGPHSAVPSWSGARSGSVSGGVFQATAAAVVFHKKRLGQRRLTDSTISSSPCAAASEKAASNASERRQPSQSGHTRSRPPR

--------------------------------------------------------------
>58167_58167_4_NDUFB2-KLC1_NDUFB2_chr7_140396642_ENST00000476279_KLC1_chr14_104166992_ENST00000348520_length(transcript)=596nt_BP=172nt
GCGGGCGGAGCGCCGGGGAAGCGAAGTAGGCAGGGGCGAGGCGGCTGGGGACCGCGGGGCGGACGGGAGCGAGTATGTCCGCTCTGACTC
GGCTGGCGTCTTTCGCTCGCGTTGGAGGCCGCCTTTTCAGAAGCGGCTGCGCACGGACTGCTGGAGATGGTGGAGTCCGTCAGGCGTCTC
TGGCCGAGCCTCTTTTTGTGGAAAACGACAGCAGCAGCAGTGGCCTGGAAGACGCCACCGCTAACTGACCCCGACCTGGCCCCGCTCCAG
GATGGGACTGCCGAGTGTGGCCCGGAGCTGGCCCGGGACAGCCAGGGCGGCAGGGAGGGCCCCTGGCCGGGAGCCGCAGCGCTCACTCAT
TTCTCCTGCGTCTGTGTGCATAGGACATGATACTAATAACCACACGGCTGGCGTGACCTTGGGGCTGGGGCTGGGCCTAAGCTGGTGCCC
TGGTGCGGCGTGGTCTCTCCCAGGAGACCTGGGGCATGAGCTGGGCCCACGGCTCCCTTCCCATGTGTAACTTCCTCACGTTGTGTGCGA

>58167_58167_4_NDUFB2-KLC1_NDUFB2_chr7_140396642_ENST00000476279_KLC1_chr14_104166992_ENST00000348520_length(amino acids)=107AA_BP=1
MPPWLSRASSGPHSAVPSWSGARSGSVSGGVFQATAAAVVFHKKRLGQRRLTDSTISSSPCAAASEKAASNASERRQPSQSGHTRSRPPR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NDUFB2-KLC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDUFB2-KLC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDUFB2-KLC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource