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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDUFB5-NAALADL2 (FusionGDB2 ID:58186)

Fusion Gene Summary for NDUFB5-NAALADL2

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFB5-NAALADL2
Fusion gene ID: 58186
HgeneTgene
Gene symbol

NDUFB5

NAALADL2

Gene ID

4711

254827

Gene nameNADH:ubiquinone oxidoreductase subunit B5N-acetylated alpha-linked acidic dipeptidase like 2
SynonymsCISGDH|SGDH-
Cytomap

3q26.33

3q26.31

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrialNADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDaNADH-ubiquinone oxidoreductase SGDH subunitcomplex I SGDH subunitcomplex I-SGDHinactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologue
Modification date2020031320200313
UniProtAcc.

Q58DX5

Ensembl transtripts involved in fusion geneENST00000473500, ENST00000259037, 
ENST00000472629, ENST00000493866, 
ENST00000454872, ENST00000473253, 
Fusion gene scores* DoF score7 X 5 X 4=14021 X 16 X 9=3024
# samples 724
** MAII scorelog2(7/140*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(24/3024*10)=-3.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFB5 [Title/Abstract] AND NAALADL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDUFB5(179336309)-NAALADL2(174951721), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NDUFB5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NAALADL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YJ-A8SW-01ANDUFB5chr3

179336309

+NAALADL2chr3

174951721

+


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Fusion Gene ORF analysis for NDUFB5-NAALADL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000473500ENST00000454872NDUFB5chr3

179336309

+NAALADL2chr3

174951721

+
3UTR-3UTRENST00000473500ENST00000473253NDUFB5chr3

179336309

+NAALADL2chr3

174951721

+
5CDS-3UTRENST00000259037ENST00000473253NDUFB5chr3

179336309

+NAALADL2chr3

174951721

+
5CDS-3UTRENST00000472629ENST00000473253NDUFB5chr3

179336309

+NAALADL2chr3

174951721

+
5CDS-3UTRENST00000493866ENST00000473253NDUFB5chr3

179336309

+NAALADL2chr3

174951721

+
In-frameENST00000259037ENST00000454872NDUFB5chr3

179336309

+NAALADL2chr3

174951721

+
In-frameENST00000472629ENST00000454872NDUFB5chr3

179336309

+NAALADL2chr3

174951721

+
In-frameENST00000493866ENST00000454872NDUFB5chr3

179336309

+NAALADL2chr3

174951721

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000259037NDUFB5chr3179336309+ENST00000454872NAALADL2chr3174951721+4843563992405768
ENST00000493866NDUFB5chr3179336309+ENST00000454872NAALADL2chr3174951721+4598318102160716
ENST00000472629NDUFB5chr3179336309+ENST00000454872NAALADL2chr3174951721+470842802270756

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000259037ENST00000454872NDUFB5chr3179336309+NAALADL2chr3174951721+0.0003000740.99969995
ENST00000493866ENST00000454872NDUFB5chr3179336309+NAALADL2chr3174951721+0.0002280650.9997719
ENST00000472629ENST00000454872NDUFB5chr3179336309+NAALADL2chr3174951721+0.0006762330.99932384

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Fusion Genomic Features for NDUFB5-NAALADL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NDUFB5chr3179336309+NAALADL2chr3174951720+1.05E-050.9999895
NDUFB5chr3179336309+NAALADL2chr3174951720+1.05E-050.9999895

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NDUFB5-NAALADL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:179336309/chr3:174951721)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NAALADL2

Q58DX5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be catalytically inactive.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDUFB5chr3:179336309chr3:174951721ENST00000259037+5673_93149190.0TransmembraneHelical
HgeneNDUFB5chr3:179336309chr3:174951721ENST00000493866+3473_9397138.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNAALADL2chr3:179336309chr3:174951721ENST00000454872114143_795181796.0Topological domainExtracellular
TgeneNAALADL2chr3:179336309chr3:174951721ENST000004548721141_121181796.0Topological domainCytoplasmic
TgeneNAALADL2chr3:179336309chr3:174951721ENST00000454872114122_142181796.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for NDUFB5-NAALADL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58186_58186_1_NDUFB5-NAALADL2_NDUFB5_chr3_179336309_ENST00000259037_NAALADL2_chr3_174951721_ENST00000454872_length(transcript)=4843nt_BP=563nt
ATAGAAAACTTGCCCTCACTTAAGATGGCCACATCCTGCCTTTGTCCTCATTGGTAAATTGGCTCTCTCAGCTTCCGTGACCCGCCTCCC
TTCTTCCTCCTGCCCGTAGTAGCCATGGCGGCCATGAGTTTGTTGCGGCGGGTTTCGGTTACTGCGGTGGCAGCTCTGTCTGGCCGGCCC
CTTGGCACTCGCCTCGGATTTGGGGGCTTCCTCACTCGTGGCTTTCCGAAGGCTGCTGCTCCTGTTCGACACAGTGGAGACCATGGGAAA
AGACTATTTGTCATCAGACCTTCTAGATTCTATGACAGGCGTTTTTTGAAGTTATTGAGATTCTACATTGCATTGACTGGGATTCCAGTA
GCAATTTTCATAACTCTGGTGAATGTATTCATTGGTCAAGCTGAACTAGCAGAAATTCCAGAAGGCTATGTCCCAGAACACTGGGAATAT
TATAAGCATCCCATATCAAGATGGATTGCCCGTAATTTCTATGATAGTCCTGAAAAGATATATGAAAGAACAATGGCCGTCCTTCAGATT
GAAGCTGAAAAGGCTGAATTACGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAATTTCAAAGAAGATTAAGACTCAGTGG
ACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCCTTCTCCCAGCACTGTGACTCTGAGC
AGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAGCCAAGACCTGCTCTATTCATATGCA
GCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGATTTAAAAAGGATTAGGAAAATAAAA
AACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTCATTGGAAAAGGCTGGATTTGGAGGT
GTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCATGGTGTCACTGAATCCAGGAGGAGAC
CCTTCTACGCCTGGTTACCCAAGTGTCGATGAAAGTTTTAGACAAAGCCGATCAAACCTCACCTCTCTATTAGTGCAGCCCATCTCTGCA
CCCCTCGTTGCAAAACTGATCTCTTCGCCAAAAGCTAGAACCAAAAATGAAGCGTGTAGCTCTCTAGAGCTTCCAAATAATGAAATAAGA
GTCGTCAGCATGCAAGTTCAGACAGTCACAAAATTGAAAACAGTTACTAATGTTGTTGGATTTGTAATGGGCTTGACATCTCCAGACCGG
TATATCATAGTTGGCAGCCATCATCACACTGCACACAGTTATAATGGACAAGAATGGGCCAGTAGTACTGCAATAATCACAGCGTTTATC
CGTGCCTTGATGTCAAAAGTTAAGAGAGGGTGGAGACCAGACCGAACTATTGTTTTCTGTTCTTGGGGAGGAACAGCTTTTGGCAATATT
GGCTCATATGAATGGGGAGAGGATTTCAAGAAGGTTCTTCAGAAAAATGTTGTGGCTTATATTAGCCTCCACAGTCCCATAAGGGGGAAC
TCTAGTCTGTATCCTGTAGCATCACCATCTCTTCAGCAACTGGTAGTAGAGAAAAATAATTTCAACTGTACCAGAAGAGCCCAGTGCCCA
GAAACCAATATCAGTTCTATACAGATACAAGGTGATGCTGATTATTTCATCAACCATCTTGGAGTTCCCATCGTGCAGTTTGCTTACGAG
GACATCAAAACATTAGAGGGTCCAAGTTTTCTCTCCGAGGCCCGTTTTTCTACACGAGCAACAAAAATTGAAGAAATGGATCCCTCTTTC
AACCTTCATGAAACCATTACTAAGCTCTCAGGAGAAGTGATTTTGCAAATTGCCAACGAACCTGTTCTGCCCTTTAATGCACTTGATATA
GCTTTAGAAGTTCAAAACAACCTTAAAGGTGATCAACCCAACACTCATCAACTGTTAGCCATGGCGTTACGCCTGCGGGAGAGTGCTGAA
CTTTTTCAGTCTGATGAGATGCGACCTGCTAATGATCCCAAGGAGAGAGCACCCATCCGCATCCGGATGCTGAATGACATTCTCCAAGAC
ATGGAGAAAAGCTTTCTGGTAAAGCAGGCACCACCAGGTTTTTATAGAAACATCCTCTACCACCTTGATGAAAAGACAAGCCGGTTTTCA
ATACTTATAGAGGCTTGGGAACACTGCAAACCCCTTGCATCAAATGAGACCCTTCAAGAAGCCCTGTCAGAGGTGTTGAACAGCATTAAT
TCAGCTCAGGTTTACTTCAAAGCAGGACTTGATGTGTTCAAGAGTGTCTTGGATGGGAAGAATTGAGAAAACTCTGAGCATTTTTAAAAG
TTTGTTTACAATTCCACAAGCAAAAGCTCTAATTTAACCAGATTTTCTGACATTGAAGGCTTATTTTCCCCAATGGCTTTTTGACAAGTA
TAAAGCTATTATTACATTGTATTTTTTAAATGTAAATATAGAAAGAACATTTTGCACATTTAATATTTTTCTTATATCTACATTTCTGAA
TATGTAAAGCAAGTTATTGAAATAGGACTTAAGAATTACCTATTAAAAAGAAATCTGATATATAAAAATATGTACTATTTTAAGGAAAAA
TTTCCAAGAAGTTCTGGACTATCTTTGTTCCTATGGGGAGGGCATATAGGAACACAGTTTATTCTCTCTGATAGAGCTATTAATGACTTA
GTTTCTGTAAAAGAAATGGAGAGTTGATATGGTTCAGATTAACTTCACTATTAAGTGTTCAATATGAAGAATTCAAGTATTCTGACTGAG
TGATTGGTTGACCTAAACCACTTTGAATGTTTCTATTTTATGAAATGAAGTTTCTCTTCTTAACACAACTAGATGTAGTAATACACTGGT
TATGAAATTGTATTTTTTTAAGTATTAATGAAAAAAGAGCCATAAGCATTCCAGGAGAAAATCTCAAGGGAGCTACATAGAGCAATTTAA
ATGCAAATTTTTTTCCTAACAACTTACAAGGTGACTAGCTTTGAAACCCCTAATTTGCCTCAGTTGATTTTCTAAGAATTTCAGGAGTGA
TGTATGTCTTAAGAGGGAGAAAAAAATATTTCTTATTACTTTTTCTCTTGTTTCTGTTGGAAACACTGAAGCAGGGACTCTAAAATGAAA
GCATCTCACATTGGTTTTCTTTCTTGTATCTTTTCTGAAACTCCTTGCTGTAAGGCAGCTTTCTCAGAGTACTATATATTTTCAACAGTA
AAGTAGCAGAGTTTCTCTTTGAAACCCAAAATGTCTTCTAAAGAATCAAATTTCTATTTCTGCCTCTGACAAAAAGAACTTACTATGAAA
GAAATAGTTGTTTTATCAATAAAAGCCCCTTAATATTATGAAGAAACTTTTCATATTTTTTCTTCTTTATCCTTAATTGTGACTAAGATG
GAAATCTAGAAAATATTCATGCTTCTAAGTTTCTGCAGTGTTACTGTAAGAGAGTGTCTCGTCTACACTTCAGTTCTTCTCTCATGTGGA
AAACTAAGCTTTTTATATTGACATTGCCATTGAATAGCTCTAGCAACTATTATTATTCCCCCAAACCCTAAAATTCTACCTATTAGGTGT
CAGGTTAAAGTTCTAATTTATCTTTAGAAATTTATGTGAAAAATGGTTTTCCTATACTGGATAAAGCAATTCCCCTTAGGAAACATAGCC
TCAGAGTATTTCATATAAATTTTCTCTATCTAATTCAAACATATCTCCCCATGATACACCGCCAGAGTGACATTGCAGACAGTCTGTGTA
TGTTTAAATTTTCACTTTTTATGGATGAGCATAAACCTAGTCTTAGTTTAAAGGCAAACTAAAGTTGAGGGGAAATAATTAATCAATACT
GATTAATTGATTTATAAGGTTCAACACTGTCTACCCTAAATAATTTTTATATGCTCAAGGCAAAGCAGGGAATAGAGGCAATTAGCTAGA
TAATTCAAGCAGAAATCCATTTTCATCGAAATTGCCTGTGTGCACATATTTTTAGATGAAAAATGAAACTACCTTACAATATTATTTTTT
TAACCAATGTATTTGTTTGCAAACATTTGCCATGTTGAAGAGTGTGTATAGGAAAGGTCTAGAAATAAATAGGCTTGTGCATACCTAGGC
ATTCATGCTCTTTCTTCCTCTTCAGAGATCATCAGAAAAGAGGTGGGAATACACAAGCAGGTGCATGTAAGCCCAAAAGCTAGAAAGCCT
TATATTTAACCAAAGGTTGATGTGTTCATTCCAGTTATTCACTTACAGATGAAACTAAAACAAATAAAGGCAAGCTATTATCAGTTTGGT
AGTTCATTATTTTAGAACAAATTTCTAAATTAATTTATTCCCATAACCTACAATAGCACTGAGAACAGAAAACATGTTTCTTCTTCATTT
TGTTTAAAGATTGCGTACCTAGGTAAGTCACACTGTATAGATAAAAACCTTCTTCTGTATTCCTCACCTCTAAATTATATGTTATTTGCT
ATTTGAAAACTGTAGTTAACTATGGTTTTTTATTAGTCTATTAAAAGATACGTGGAGATATTAAATTATACCTAAAGCAGACGTCCAACA
AATTCTGTACATGCTGCTTTACATCTTTGCAACAAACCTCTTAACTAGCAGCATTATTTCTATAGTGTGATTACCTGAGGGTGCCTCCAA

>58186_58186_1_NDUFB5-NAALADL2_NDUFB5_chr3_179336309_ENST00000259037_NAALADL2_chr3_174951721_ENST00000454872_length(amino acids)=768AA_BP=154
MPVVAMAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRHSGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIF
ITLVNVFIGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEKAELRNLVQLYKNEDDMEISKKIKTQWTSL
GLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVT
NQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGYPSVDESFRQSRSNLTSLLVQPISAPLV
AKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRAL
MSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASPSLQQLVVEKNNFNCTRRAQCPETN
ISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALE
VQNNLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFLVKQAPPGFYRNILYHLDEKTSRFSILI

--------------------------------------------------------------
>58186_58186_2_NDUFB5-NAALADL2_NDUFB5_chr3_179336309_ENST00000472629_NAALADL2_chr3_174951721_ENST00000454872_length(transcript)=4708nt_BP=428nt
CTGCCCGTAGTAGCCATGGCGGCCATGAGTTTGTTGCGGCGGGTTTCGGTTACTGCGGTGGCAGCTCTGTCTGGCCGGCCCCTTGGCACT
CGCCTCGGATTTGGGGGCTTCCTCACTCGTGGCTTTCCGAAGGCTGCTGCCCCTGGTAACCACCATTCTGCTGTCTTTATGATTTTGACT
ACTCTATTTCTCATATTCTACATTGCATTGACTGGGATTCCAGTAGCAATTTTCATAACTCTGGTGAATGTATTCATTGGTCAAGCTGAA
CTAGCAGAAATTCCAGAAGGCTATGTCCCAGAACACTGGGAATATTATAAGCATCCCATATCAAGATGGATTGCCCGTAATTTCTATGAT
AGTCCTGAAAAGATATATGAAAGAACAATGGCCGTCCTTCAGATTGAAGCTGAAAAGGCTGAATTACGAAATTTGGTACAACTATATAAA
AATGAAGATGACATGGAAATTTCAAAGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTG
CTGCTTGATCTGCCAGGCCCTTCTCCCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAA
GAAGCCAGAAAAGATAGCAGCCAAGACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTG
AGTTATGGAATGGCAGATGATTTAAAAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCA
CTGCTTTATAAGCTTTCCTCATTGGAAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAAT
CCTAGCCATGATACCTTCATGGTGTCACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGATGAAAGTTTTAGACAA
AGCCGATCAAACCTCACCTCTCTATTAGTGCAGCCCATCTCTGCACCCCTCGTTGCAAAACTGATCTCTTCGCCAAAAGCTAGAACCAAA
AATGAAGCGTGTAGCTCTCTAGAGCTTCCAAATAATGAAATAAGAGTCGTCAGCATGCAAGTTCAGACAGTCACAAAATTGAAAACAGTT
ACTAATGTTGTTGGATTTGTAATGGGCTTGACATCTCCAGACCGGTATATCATAGTTGGCAGCCATCATCACACTGCACACAGTTATAAT
GGACAAGAATGGGCCAGTAGTACTGCAATAATCACAGCGTTTATCCGTGCCTTGATGTCAAAAGTTAAGAGAGGGTGGAGACCAGACCGA
ACTATTGTTTTCTGTTCTTGGGGAGGAACAGCTTTTGGCAATATTGGCTCATATGAATGGGGAGAGGATTTCAAGAAGGTTCTTCAGAAA
AATGTTGTGGCTTATATTAGCCTCCACAGTCCCATAAGGGGGAACTCTAGTCTGTATCCTGTAGCATCACCATCTCTTCAGCAACTGGTA
GTAGAGAAAAATAATTTCAACTGTACCAGAAGAGCCCAGTGCCCAGAAACCAATATCAGTTCTATACAGATACAAGGTGATGCTGATTAT
TTCATCAACCATCTTGGAGTTCCCATCGTGCAGTTTGCTTACGAGGACATCAAAACATTAGAGGGTCCAAGTTTTCTCTCCGAGGCCCGT
TTTTCTACACGAGCAACAAAAATTGAAGAAATGGATCCCTCTTTCAACCTTCATGAAACCATTACTAAGCTCTCAGGAGAAGTGATTTTG
CAAATTGCCAACGAACCTGTTCTGCCCTTTAATGCACTTGATATAGCTTTAGAAGTTCAAAACAACCTTAAAGGTGATCAACCCAACACT
CATCAACTGTTAGCCATGGCGTTACGCCTGCGGGAGAGTGCTGAACTTTTTCAGTCTGATGAGATGCGACCTGCTAATGATCCCAAGGAG
AGAGCACCCATCCGCATCCGGATGCTGAATGACATTCTCCAAGACATGGAGAAAAGCTTTCTGGTAAAGCAGGCACCACCAGGTTTTTAT
AGAAACATCCTCTACCACCTTGATGAAAAGACAAGCCGGTTTTCAATACTTATAGAGGCTTGGGAACACTGCAAACCCCTTGCATCAAAT
GAGACCCTTCAAGAAGCCCTGTCAGAGGTGTTGAACAGCATTAATTCAGCTCAGGTTTACTTCAAAGCAGGACTTGATGTGTTCAAGAGT
GTCTTGGATGGGAAGAATTGAGAAAACTCTGAGCATTTTTAAAAGTTTGTTTACAATTCCACAAGCAAAAGCTCTAATTTAACCAGATTT
TCTGACATTGAAGGCTTATTTTCCCCAATGGCTTTTTGACAAGTATAAAGCTATTATTACATTGTATTTTTTAAATGTAAATATAGAAAG
AACATTTTGCACATTTAATATTTTTCTTATATCTACATTTCTGAATATGTAAAGCAAGTTATTGAAATAGGACTTAAGAATTACCTATTA
AAAAGAAATCTGATATATAAAAATATGTACTATTTTAAGGAAAAATTTCCAAGAAGTTCTGGACTATCTTTGTTCCTATGGGGAGGGCAT
ATAGGAACACAGTTTATTCTCTCTGATAGAGCTATTAATGACTTAGTTTCTGTAAAAGAAATGGAGAGTTGATATGGTTCAGATTAACTT
CACTATTAAGTGTTCAATATGAAGAATTCAAGTATTCTGACTGAGTGATTGGTTGACCTAAACCACTTTGAATGTTTCTATTTTATGAAA
TGAAGTTTCTCTTCTTAACACAACTAGATGTAGTAATACACTGGTTATGAAATTGTATTTTTTTAAGTATTAATGAAAAAAGAGCCATAA
GCATTCCAGGAGAAAATCTCAAGGGAGCTACATAGAGCAATTTAAATGCAAATTTTTTTCCTAACAACTTACAAGGTGACTAGCTTTGAA
ACCCCTAATTTGCCTCAGTTGATTTTCTAAGAATTTCAGGAGTGATGTATGTCTTAAGAGGGAGAAAAAAATATTTCTTATTACTTTTTC
TCTTGTTTCTGTTGGAAACACTGAAGCAGGGACTCTAAAATGAAAGCATCTCACATTGGTTTTCTTTCTTGTATCTTTTCTGAAACTCCT
TGCTGTAAGGCAGCTTTCTCAGAGTACTATATATTTTCAACAGTAAAGTAGCAGAGTTTCTCTTTGAAACCCAAAATGTCTTCTAAAGAA
TCAAATTTCTATTTCTGCCTCTGACAAAAAGAACTTACTATGAAAGAAATAGTTGTTTTATCAATAAAAGCCCCTTAATATTATGAAGAA
ACTTTTCATATTTTTTCTTCTTTATCCTTAATTGTGACTAAGATGGAAATCTAGAAAATATTCATGCTTCTAAGTTTCTGCAGTGTTACT
GTAAGAGAGTGTCTCGTCTACACTTCAGTTCTTCTCTCATGTGGAAAACTAAGCTTTTTATATTGACATTGCCATTGAATAGCTCTAGCA
ACTATTATTATTCCCCCAAACCCTAAAATTCTACCTATTAGGTGTCAGGTTAAAGTTCTAATTTATCTTTAGAAATTTATGTGAAAAATG
GTTTTCCTATACTGGATAAAGCAATTCCCCTTAGGAAACATAGCCTCAGAGTATTTCATATAAATTTTCTCTATCTAATTCAAACATATC
TCCCCATGATACACCGCCAGAGTGACATTGCAGACAGTCTGTGTATGTTTAAATTTTCACTTTTTATGGATGAGCATAAACCTAGTCTTA
GTTTAAAGGCAAACTAAAGTTGAGGGGAAATAATTAATCAATACTGATTAATTGATTTATAAGGTTCAACACTGTCTACCCTAAATAATT
TTTATATGCTCAAGGCAAAGCAGGGAATAGAGGCAATTAGCTAGATAATTCAAGCAGAAATCCATTTTCATCGAAATTGCCTGTGTGCAC
ATATTTTTAGATGAAAAATGAAACTACCTTACAATATTATTTTTTTAACCAATGTATTTGTTTGCAAACATTTGCCATGTTGAAGAGTGT
GTATAGGAAAGGTCTAGAAATAAATAGGCTTGTGCATACCTAGGCATTCATGCTCTTTCTTCCTCTTCAGAGATCATCAGAAAAGAGGTG
GGAATACACAAGCAGGTGCATGTAAGCCCAAAAGCTAGAAAGCCTTATATTTAACCAAAGGTTGATGTGTTCATTCCAGTTATTCACTTA
CAGATGAAACTAAAACAAATAAAGGCAAGCTATTATCAGTTTGGTAGTTCATTATTTTAGAACAAATTTCTAAATTAATTTATTCCCATA
ACCTACAATAGCACTGAGAACAGAAAACATGTTTCTTCTTCATTTTGTTTAAAGATTGCGTACCTAGGTAAGTCACACTGTATAGATAAA
AACCTTCTTCTGTATTCCTCACCTCTAAATTATATGTTATTTGCTATTTGAAAACTGTAGTTAACTATGGTTTTTTATTAGTCTATTAAA
AGATACGTGGAGATATTAAATTATACCTAAAGCAGACGTCCAACAAATTCTGTACATGCTGCTTTACATCTTTGCAACAAACCTCTTAAC
TAGCAGCATTATTTCTATAGTGTGATTACCTGAGGGTGCCTCCAAATGTATATCATTTCACTCCCCTCCCCTCCCCACCCCCAATAGATT

>58186_58186_2_NDUFB5-NAALADL2_NDUFB5_chr3_179336309_ENST00000472629_NAALADL2_chr3_174951721_ENST00000454872_length(amino acids)=756AA_BP=142
LPVVAMAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPGNHHSAVFMILTTLFLIFYIALTGIPVAIFITLVNVFIGQAE
LAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEKAELRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSV
LLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLP
LLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGYPSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTK
NEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDR
TIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADY
FINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNT
HQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFLVKQAPPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASN

--------------------------------------------------------------
>58186_58186_3_NDUFB5-NAALADL2_NDUFB5_chr3_179336309_ENST00000493866_NAALADL2_chr3_174951721_ENST00000454872_length(transcript)=4598nt_BP=318nt
CTTCTTCCTCCTGCCCGTAGTAGCCATGGCGGCCATGAGTTTGTTGCGGCGGGTTTCGGTTACTGCGGTGGCAGCTCTGTCTGGCCGGCC
CCTTGGCACTCGCCTCGGATTTGGGGGCTTCCTCACTCGTGGCTTTCCGAAGGCTGCTGGTCAAGCTGAACTAGCAGAAATTCCAGAAGG
CTATGTCCCAGAACACTGGGAATATTATAAGCATCCCATATCAAGATGGATTGCCCGTAATTTCTATGATAGTCCTGAAAAGATATATGA
AAGAACAATGGCCGTCCTTCAGATTGAAGCTGAAAAGGCTGAATTACGAAATTTGGTACAACTATATAAAAATGAAGATGACATGGAAAT
TTCAAAGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTCTGTGCTGCTTGATCTGCCAGGCCC
TTCTCCCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAGTGAAGAAGCCAGAAAAGATAGCAG
CCAAGACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGATGTGAGTTATGGAATGGCAGATGA
TTTAAAAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATTGCCACTGCTTTATAAGCTTTCCTC
ATTGGAAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGTGAATCCTAGCCATGATACCTTCAT
GGTGTCACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGATGAAAGTTTTAGACAAAGCCGATCAAACCTCACCTC
TCTATTAGTGCAGCCCATCTCTGCACCCCTCGTTGCAAAACTGATCTCTTCGCCAAAAGCTAGAACCAAAAATGAAGCGTGTAGCTCTCT
AGAGCTTCCAAATAATGAAATAAGAGTCGTCAGCATGCAAGTTCAGACAGTCACAAAATTGAAAACAGTTACTAATGTTGTTGGATTTGT
AATGGGCTTGACATCTCCAGACCGGTATATCATAGTTGGCAGCCATCATCACACTGCACACAGTTATAATGGACAAGAATGGGCCAGTAG
TACTGCAATAATCACAGCGTTTATCCGTGCCTTGATGTCAAAAGTTAAGAGAGGGTGGAGACCAGACCGAACTATTGTTTTCTGTTCTTG
GGGAGGAACAGCTTTTGGCAATATTGGCTCATATGAATGGGGAGAGGATTTCAAGAAGGTTCTTCAGAAAAATGTTGTGGCTTATATTAG
CCTCCACAGTCCCATAAGGGGGAACTCTAGTCTGTATCCTGTAGCATCACCATCTCTTCAGCAACTGGTAGTAGAGAAAAATAATTTCAA
CTGTACCAGAAGAGCCCAGTGCCCAGAAACCAATATCAGTTCTATACAGATACAAGGTGATGCTGATTATTTCATCAACCATCTTGGAGT
TCCCATCGTGCAGTTTGCTTACGAGGACATCAAAACATTAGAGGGTCCAAGTTTTCTCTCCGAGGCCCGTTTTTCTACACGAGCAACAAA
AATTGAAGAAATGGATCCCTCTTTCAACCTTCATGAAACCATTACTAAGCTCTCAGGAGAAGTGATTTTGCAAATTGCCAACGAACCTGT
TCTGCCCTTTAATGCACTTGATATAGCTTTAGAAGTTCAAAACAACCTTAAAGGTGATCAACCCAACACTCATCAACTGTTAGCCATGGC
GTTACGCCTGCGGGAGAGTGCTGAACTTTTTCAGTCTGATGAGATGCGACCTGCTAATGATCCCAAGGAGAGAGCACCCATCCGCATCCG
GATGCTGAATGACATTCTCCAAGACATGGAGAAAAGCTTTCTGGTAAAGCAGGCACCACCAGGTTTTTATAGAAACATCCTCTACCACCT
TGATGAAAAGACAAGCCGGTTTTCAATACTTATAGAGGCTTGGGAACACTGCAAACCCCTTGCATCAAATGAGACCCTTCAAGAAGCCCT
GTCAGAGGTGTTGAACAGCATTAATTCAGCTCAGGTTTACTTCAAAGCAGGACTTGATGTGTTCAAGAGTGTCTTGGATGGGAAGAATTG
AGAAAACTCTGAGCATTTTTAAAAGTTTGTTTACAATTCCACAAGCAAAAGCTCTAATTTAACCAGATTTTCTGACATTGAAGGCTTATT
TTCCCCAATGGCTTTTTGACAAGTATAAAGCTATTATTACATTGTATTTTTTAAATGTAAATATAGAAAGAACATTTTGCACATTTAATA
TTTTTCTTATATCTACATTTCTGAATATGTAAAGCAAGTTATTGAAATAGGACTTAAGAATTACCTATTAAAAAGAAATCTGATATATAA
AAATATGTACTATTTTAAGGAAAAATTTCCAAGAAGTTCTGGACTATCTTTGTTCCTATGGGGAGGGCATATAGGAACACAGTTTATTCT
CTCTGATAGAGCTATTAATGACTTAGTTTCTGTAAAAGAAATGGAGAGTTGATATGGTTCAGATTAACTTCACTATTAAGTGTTCAATAT
GAAGAATTCAAGTATTCTGACTGAGTGATTGGTTGACCTAAACCACTTTGAATGTTTCTATTTTATGAAATGAAGTTTCTCTTCTTAACA
CAACTAGATGTAGTAATACACTGGTTATGAAATTGTATTTTTTTAAGTATTAATGAAAAAAGAGCCATAAGCATTCCAGGAGAAAATCTC
AAGGGAGCTACATAGAGCAATTTAAATGCAAATTTTTTTCCTAACAACTTACAAGGTGACTAGCTTTGAAACCCCTAATTTGCCTCAGTT
GATTTTCTAAGAATTTCAGGAGTGATGTATGTCTTAAGAGGGAGAAAAAAATATTTCTTATTACTTTTTCTCTTGTTTCTGTTGGAAACA
CTGAAGCAGGGACTCTAAAATGAAAGCATCTCACATTGGTTTTCTTTCTTGTATCTTTTCTGAAACTCCTTGCTGTAAGGCAGCTTTCTC
AGAGTACTATATATTTTCAACAGTAAAGTAGCAGAGTTTCTCTTTGAAACCCAAAATGTCTTCTAAAGAATCAAATTTCTATTTCTGCCT
CTGACAAAAAGAACTTACTATGAAAGAAATAGTTGTTTTATCAATAAAAGCCCCTTAATATTATGAAGAAACTTTTCATATTTTTTCTTC
TTTATCCTTAATTGTGACTAAGATGGAAATCTAGAAAATATTCATGCTTCTAAGTTTCTGCAGTGTTACTGTAAGAGAGTGTCTCGTCTA
CACTTCAGTTCTTCTCTCATGTGGAAAACTAAGCTTTTTATATTGACATTGCCATTGAATAGCTCTAGCAACTATTATTATTCCCCCAAA
CCCTAAAATTCTACCTATTAGGTGTCAGGTTAAAGTTCTAATTTATCTTTAGAAATTTATGTGAAAAATGGTTTTCCTATACTGGATAAA
GCAATTCCCCTTAGGAAACATAGCCTCAGAGTATTTCATATAAATTTTCTCTATCTAATTCAAACATATCTCCCCATGATACACCGCCAG
AGTGACATTGCAGACAGTCTGTGTATGTTTAAATTTTCACTTTTTATGGATGAGCATAAACCTAGTCTTAGTTTAAAGGCAAACTAAAGT
TGAGGGGAAATAATTAATCAATACTGATTAATTGATTTATAAGGTTCAACACTGTCTACCCTAAATAATTTTTATATGCTCAAGGCAAAG
CAGGGAATAGAGGCAATTAGCTAGATAATTCAAGCAGAAATCCATTTTCATCGAAATTGCCTGTGTGCACATATTTTTAGATGAAAAATG
AAACTACCTTACAATATTATTTTTTTAACCAATGTATTTGTTTGCAAACATTTGCCATGTTGAAGAGTGTGTATAGGAAAGGTCTAGAAA
TAAATAGGCTTGTGCATACCTAGGCATTCATGCTCTTTCTTCCTCTTCAGAGATCATCAGAAAAGAGGTGGGAATACACAAGCAGGTGCA
TGTAAGCCCAAAAGCTAGAAAGCCTTATATTTAACCAAAGGTTGATGTGTTCATTCCAGTTATTCACTTACAGATGAAACTAAAACAAAT
AAAGGCAAGCTATTATCAGTTTGGTAGTTCATTATTTTAGAACAAATTTCTAAATTAATTTATTCCCATAACCTACAATAGCACTGAGAA
CAGAAAACATGTTTCTTCTTCATTTTGTTTAAAGATTGCGTACCTAGGTAAGTCACACTGTATAGATAAAAACCTTCTTCTGTATTCCTC
ACCTCTAAATTATATGTTATTTGCTATTTGAAAACTGTAGTTAACTATGGTTTTTTATTAGTCTATTAAAAGATACGTGGAGATATTAAA
TTATACCTAAAGCAGACGTCCAACAAATTCTGTACATGCTGCTTTACATCTTTGCAACAAACCTCTTAACTAGCAGCATTATTTCTATAG
TGTGATTACCTGAGGGTGCCTCCAAATGTATATCATTTCACTCCCCTCCCCTCCCCACCCCCAATAGATTCAAATAAATAAAATCCTGAG

>58186_58186_3_NDUFB5-NAALADL2_NDUFB5_chr3_179336309_ENST00000493866_NAALADL2_chr3_174951721_ENST00000454872_length(amino acids)=716AA_BP=102
MPVVAMAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTM
AVLQIEAEKAELRNLVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDL
LYSYAAYSAKGTLKAEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSL
NPGGDPSTPGYPSVDESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGL
TSPDRYIIVGSHHHTAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHS
PIRGNSSLYPVASPSLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEE
MDPSFNLHETITKLSGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NDUFB5-NAALADL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDUFB5-NAALADL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDUFB5-NAALADL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource