FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NDUFB6-ASAP2 (FusionGDB2 ID:58188)

Fusion Gene Summary for NDUFB6-ASAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFB6-ASAP2
Fusion gene ID: 58188
HgeneTgene
Gene symbol

NDUFB6

ASAP2

Gene ID

4712

8853

Gene nameNADH:ubiquinone oxidoreductase subunit B6ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
SynonymsB17|CIAMAP2|CENTB3|DDEF2|PAG3|PAP|Pap-alpha|SHAG1
Cytomap

9p21.1

2p25.1|2p24

Type of geneprotein-codingprotein-coding
DescriptionNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6CI-B17NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDaNADH-ubiquinone oxidoreductase B17 subunitNADH-ubiquinone oxidoreductase beta subunit, 6complex I, mitochondrial respiratory carf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2PYK2 C terminus-associated proteincentaurin, beta 3development and differentiation-enhancing factor 2paxillin-associated protein with ARF GAP activity 3pyk2 C-terminus-associated p
Modification date2020031320200327
UniProtAcc.

O43150

Ensembl transtripts involved in fusion geneENST00000379847, ENST00000350021, 
ENST00000491413, ENST00000281419, 
ENST00000315273, 
Fusion gene scores* DoF score2 X 3 X 1=69 X 10 X 4=360
# samples 311
** MAII scorelog2(3/6*10)=2.32192809488736log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFB6 [Title/Abstract] AND ASAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDUFB6(32558908)-ASAP2(9484661), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NDUFB6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ASAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CG-5724-01ANDUFB6chr9

32558908

-ASAP2chr2

9484661

+


Top

Fusion Gene ORF analysis for NDUFB6-ASAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379847ENST00000491413NDUFB6chr9

32558908

-ASAP2chr2

9484661

+
In-frameENST00000379847ENST00000281419NDUFB6chr9

32558908

-ASAP2chr2

9484661

+
In-frameENST00000379847ENST00000315273NDUFB6chr9

32558908

-ASAP2chr2

9484661

+
intron-3CDSENST00000350021ENST00000281419NDUFB6chr9

32558908

-ASAP2chr2

9484661

+
intron-3CDSENST00000350021ENST00000315273NDUFB6chr9

32558908

-ASAP2chr2

9484661

+
intron-intronENST00000350021ENST00000491413NDUFB6chr9

32558908

-ASAP2chr2

9484661

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379847NDUFB6chr932558908-ENST00000281419ASAP2chr29484661+49434201022591829
ENST00000379847NDUFB6chr932558908-ENST00000315273ASAP2chr29484661+48134201022456784

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379847ENST00000281419NDUFB6chr932558908-ASAP2chr29484661+0.0004108540.99958915
ENST00000379847ENST00000315273NDUFB6chr932558908-ASAP2chr29484661+0.0004605390.9995395

Top

Fusion Genomic Features for NDUFB6-ASAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NDUFB6chr932558907-ASAP2chr29484660+0.0003010530.999699
NDUFB6chr932558907-ASAP2chr29484660+0.0003010530.999699

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for NDUFB6-ASAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:32558908/chr2:9484661)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASAP2

O43150

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration. {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10749932, ECO:0000269|PubMed:11304556}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDUFB6chr9:32558908chr2:9484661ENST00000379847-3468_86106129.0TransmembraneHelical
TgeneASAP2chr9:32558908chr2:9484661ENST00000281419828729_7522831007.0Coiled coilOntology_term=ECO:0000255
TgeneASAP2chr9:32558908chr2:9484661ENST00000315273827729_752283962.0Coiled coilOntology_term=ECO:0000255
TgeneASAP2chr9:32558908chr2:9484661ENST00000281419828771_9362831007.0Compositional biasNote=Pro-rich
TgeneASAP2chr9:32558908chr2:9484661ENST00000315273827771_936283962.0Compositional biasNote=Pro-rich
TgeneASAP2chr9:32558908chr2:9484661ENST00000281419828305_3972831007.0DomainPH
TgeneASAP2chr9:32558908chr2:9484661ENST00000281419828421_5432831007.0DomainArf-GAP
TgeneASAP2chr9:32558908chr2:9484661ENST00000281419828944_10062831007.0DomainSH3
TgeneASAP2chr9:32558908chr2:9484661ENST00000315273827305_397283962.0DomainPH
TgeneASAP2chr9:32558908chr2:9484661ENST00000315273827421_543283962.0DomainArf-GAP
TgeneASAP2chr9:32558908chr2:9484661ENST00000315273827944_1006283962.0DomainSH3
TgeneASAP2chr9:32558908chr2:9484661ENST00000281419828584_6162831007.0RepeatNote=ANK 1
TgeneASAP2chr9:32558908chr2:9484661ENST00000281419828620_6492831007.0RepeatNote=ANK 2
TgeneASAP2chr9:32558908chr2:9484661ENST00000315273827584_616283962.0RepeatNote=ANK 1
TgeneASAP2chr9:32558908chr2:9484661ENST00000315273827620_649283962.0RepeatNote=ANK 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDUFB6chr9:32558908chr2:9484661ENST00000350021-1368_860114.0TransmembraneHelical
TgeneASAP2chr9:32558908chr2:9484661ENST00000281419828256_2832831007.0Coiled coilOntology_term=ECO:0000255
TgeneASAP2chr9:32558908chr2:9484661ENST00000315273827256_283283962.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for NDUFB6-ASAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58188_58188_1_NDUFB6-ASAP2_NDUFB6_chr9_32558908_ENST00000379847_ASAP2_chr2_9484661_ENST00000281419_length(transcript)=4943nt_BP=420nt
GGCGTTCCCGCAAGGTCGCTTTGCAGAGCGGGAGCGCGCTTAAGTAACTAGTCCGTAGTTCGAGGGTGCGCCGTGTCCTTTTGCGTTGGT
ACCAGCGGCGACATGACGGGGTACACTCCGGATGAGAAACTGCGGCTGCAGCAGCTGCGAGAGCTGAGAAGGCGATGGCTGAAGGACCAG
GAGCTGAGCCCTCGGGAGCCGGTGCTGCCCCCACAGAAGATGGGGCCTATGGAGAAATTCTGGAATAAATTTTTGGAGAATAAATCCCCT
TGGAGGAAAATGGTCCATGGGGTATACAAAAAGAGTATCTTTGTTTTCACTCATGTACTTGTACCTGTCTGGATTATTCATTATTACATG
AAGTATCATGTTTCTGAAAAACCATATGGCATAGTTGAAAAGAAGTCCAGAATATTCCCTGACTCCCAAATTCGTCAGAGCACAGCTTAT
AGCTTACATCAGCCTCAGGGAAACAAGGAACATGGGACCGAGCGGAACGGCAGCCTCTACAAGAAGAGTGACGGGATCCGAAAAGTGTGG
CAGAAAAGGAAATGTTCAGTTAAAAATGGTTTTCTGACCATATCCCATGGTACCGCTAACCGGCCTCCTGCAAAGCTCAACCTGCTAACC
TGCCAGGTGAAGACCAACCCTGAGGAGAAGAAGTGCTTTGACCTCATTTCACATGACAGAACTTACCACTTTCAAGCTGAAGATGAACAG
GAATGTCAAATATGGATGTCTGTGCTGCAAAATAGCAAAGAAGAAGCTTTAAACAATGCATTTAAGGGGGATGACAATACTGGAGAAAAT
AACATCGTCCAAGAACTGACAAAGGAGATCATCTCAGAAGTGCAGAGGATGACGGGCAATGACGTCTGCTGTGACTGTGGGGCGCCAGAT
CCTACATGGCTTTCCACCAACCTGGGCATCCTGACCTGCATCGAGTGTTCCGGAATCCACCGAGAGCTGGGGGTTCATTATTCCAGGATG
CAGTCCCTGACCTTAGATGTACTGGGAACATCTGAGCTGCTGCTCGCCAAGAATATTGGGAATGCAGGCTTTAATGAGATCATGGAATGT
TGCCTACCAGCTGAGGACTCAGTCAAACCCAACCCAGGCAGCGACATGAATGCAAGAAAGGACTACATCACAGCCAAGTACATCGAGAGG
AGATACGCAAGGAAGAAGCACGCGGATAACGCGGCGAAGCTTCACAGTCTTTGCGAGGCCGTCAAAACGAGAGATATTTTTGGATTGCTC
CAAGCTTATGCTGATGGTGTGGATCTTACGGAAAAAATCCCACTGGCCAACGGACATGAGCCGGATGAAACGGCCCTCCACCTTGCAGTC
AGATCCGTGGATCGAACCTCTCTTCACATTGTAGACTTTTTAGTTCAGAACAGTGGGAACCTGGATAAACAGACAGGGAAAGGCAGCACA
GCCCTGCACTACTGCTGCCTGACCGACAATGCCGAGTGCCTCAAGTTGCTCCTGCGGGGGAAGGCCTCCATCGAGATAGCAAACGAGTCA
GGAGAGACTCCGCTGGACATTGCCAAGCGCCTCAAGCACGAGCACTGTGAGGAGCTGCTGACCCAAGCCTTATCTGGAAGATTTAATTCT
CACGTTCACGTTGAATATGAATGGCGACTACTCCACGAAGACCTGGATGAAAGTGATGACGACATGGATGAGAAATTGCAGCCCAGTCCC
AACCGGCGGGAAGACCGGCCCATCAGCTTCTACCAGCTGGGCTCCAACCAGCTTCAGTCTAACGCTGTATCTTTGGCCAGAGATGCTGCA
AACCTTGCCAAGGAGAAGCAGAGGGCTTTCATGCCCAGCATCTTGCAGAATGAGACTTACGGAGCCCTCCTGAGTGGCAGCCCACCTCCC
GCCCAGCCTGCAGCCCCCAGCACCACCAGCGCCCCCCCGCTTCCTCCACGGAATGTTGGCAAAGTTCAGACAGCCTCCTCTGCTAACACC
CTGTGGAAGACAAACTCTGTAAGTGTGGACGGTGGAAGCCGGCAGCGATCTTCGTCAGATCCGCCAGCTGTCCATCCACCGCTGCCCCCT
CTTCGCGTGACATCTACCAATCCCCTGACCCCCACGCCGCCCCCACCCGTTGCCAAGACGCCCAGCGTAATGGAAGCCTTGAGCCAGCCG
AGCAAGCCTGCCCCGCCTGGGATCTCACAGATCAGGCCCCCACCTCTGCCCCCACAGCCGCCCAGCCGCCTCCCGCAGAAGAAGCCTGCG
CCGGGGGCTGACAAGTCCACCCCACTGACCAACAAAGGCCAACCGAGAGGACCTGTGGATCTCTCTGCAACGGAAGCTCTGGGTCCTCTG
TCCAATGCTATGGTCCTGCAGCCCCCTGCACCCATGCCTAGGAAGTCGCAGGCAACCAAGTTGAAGCCTAAGCGGGTGAAAGCGCTCTAT
AACTGTGTGGCTGACAACCCCGATGAGCTCACCTTCTCCGAGGGGGATGTGATCATCGTGGACGGGGAGGAGGACCAGGAGTGGTGGATT
GGCCACATTGATGGAGATCCTGGTCGCAAAGGCGCATTCCCGGTGTCATTTGTGCACTTTATCGCTGACTGAATTGCTACTGAACAAAAG
CATTAACAGTTATGTTCCTGTTTCGTTATTGGTACCAAAACTCTTGCCAGATAACCAGTTTCATGAACTGTTTGTATGGCAGCCCATGTT
CTCTAATGCCACTGCTCTGTTTTAAAAACTCAGAGGCAATTTTTACATATCAGTAATTGTTTTTATAATTTGTGGTTTTCATGAAACATT
GCTATGCATTTATTAGGAAAAACTGAATTTCCCAACAGGTGAACTGAAAAGTTATTTTAACTATTATACATAATCAAGATCCTGCCTCTA
CGGAATTAGCTAAACCTAAAAATGTTTGCATTAATGAATAAATTCTTCCTGCATTCCTTGGCCCAGTTCTGGAGTTGGTGACCTTTATCA
CAATTATTATTTTAGGCGGCCAGTGAACTGCTGCTTCAGAAGTCCATAGCCCAGCTCTGAACTTTCTCGATAAAATGCCATCAGTTCACC
TTTAAAGACACACATTCCTTTGAAATCCACCCAGTGTTTAAAAAGCAACTTGGAAATTTACACATTAGCATTGTACTTTCTAGCCCTAAT
TTGTGAGGTTGCAGCTATCATTATATTCTGCATGTATGTATAACCTGTTGTGAACAATCATACTTAACAAAACTACTGATGGTTTATGAC
AACGTAGGGTAACTACAGTTCATTCTGTTCCAGGTTATATAAAACTGCATTTCCTGAATTTGGTTAAAAACTAAGGATGATGGATTGCAA
AACAGTTCTTTTAAATTAGTTTATATGCTTTAGGTGTTTTGGAATTTGCCTTCTTGAACTTCCTGAGTCACACAGAAAGCAACTGTACAC
AGTAGAATTCTGTGGCGCAGACCATGCTGTATTAACACATCACTTGCTGTTTCCTACTGAGTGTACCACTGCCTTCCCTTCTAGCCCAGG
AGAATGTTTACTCAGTTTAGTGTCTTGTATTTCTATAATACTCCAACAGGAATGGTAGTCACACTGTCTTGAAATTGAATCTGTCCATCT
GTTTATAATCAAGAACATATCAGAAATATATAGGTCCCAGGTAATACTCCCAAACATCCCACTTTTTACTGTTTCAGGCCATCATATCAT
TCTTAAGCTACTTGGGGTGGTAGTAGAGGATTAGGTTGTCTATTATAAAACCAAAACTCATTCGTTTAATGAACTTGACTGTCATACCTC
TATTTAGTAATTGCGAGGGTAAGATTCATAGTAGGAATATTGGAAATTTTGGCACTCTGAGAATAAATAGGCATATGATACCCACTTGGA
CTTTTAACAAAAGTAAAGGAATAAATTTGCATATAGGCTTGGAAAGTGAGGCAGCAATGCTGTTAACTGCATTTGTTGTGATGGTGCATT
TGATTGAAGCAGCTTGTCTTTATTATGCAAGACTGTGTAGAGTTTTTTTTTTTTTTGGCATTGTACTTTTTGTTTTTGTTATAAAGGAAG
ACAGAACAAACTGGAATGTTTTATGATGTTGTATAGCAATCGCTTTTTACCTTTCAAAGTTCCGGGTAAAAATGTGTTATATCTGTAGTT
TTTTGTTTTTGTTTTTTTTTAAAGCACTACATCTGTTTTCACTAATTGTTAATTTCTGTTTGAACCCTTCATTTAATTTTCTCATAGATT
TAAGTAAACAGATGTATTTTGCACAGTGCACTTATGTCTATTTTAACAATCCTCCTGCATCTGTATTTTATAGTCAGCCTTTTGACCACC
TGGTGCCAGCTATATAAGGAATAAAGTTGATTCATATCAACATTAGAACTCCAGTCCCAAACTAATCTGTCAGGTTCACTGGTACATAAA
TACCTAGGAAATATTTTTCCAGTCTACAATTTGGTGCTATTGTGCAGTAACTAATAGTACTCTTACCAGAGGAGAAATTATATTAACGAC
CCTGCTAATATCCTTTCTTAGTTATTTGCTCCTTGCAAATTAAAAAAGCAACTAAGAGAAAGAAAAACATTGTAGATATCTATTTATATT
TAAAGTTTATGTTTCATGAACTGCAGCTGCAGGATTCTGGCATTTTGCATGCCATTCTCCATCAGATCTGGGATGATGGCTCAGAACATG
TACACAGACTAAGAGTAACTGTGTGATCTGTTAAGGGGTGGATAACATAATATGCAGCTTAGGATGCTATTTTGAGATGTATGATATTCA
GTTCATTCACCTGATTACTTTGGTTGCAGCACAACTGTATATATTGTATAACCGAAATTGATTATTTTCATTGTCCTTAATGCAGTGATT

>58188_58188_1_NDUFB6-ASAP2_NDUFB6_chr9_32558908_ENST00000379847_ASAP2_chr2_9484661_ENST00000281419_length(amino acids)=829AA_BP=103
MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVWIIHYYMKYHV
SEKPYGIVEKKSRIFPDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVK
TNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWL
STNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYAR
KKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHY
CCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRRE
DRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKT
NSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGAD
KSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHID

--------------------------------------------------------------
>58188_58188_2_NDUFB6-ASAP2_NDUFB6_chr9_32558908_ENST00000379847_ASAP2_chr2_9484661_ENST00000315273_length(transcript)=4813nt_BP=420nt
GGCGTTCCCGCAAGGTCGCTTTGCAGAGCGGGAGCGCGCTTAAGTAACTAGTCCGTAGTTCGAGGGTGCGCCGTGTCCTTTTGCGTTGGT
ACCAGCGGCGACATGACGGGGTACACTCCGGATGAGAAACTGCGGCTGCAGCAGCTGCGAGAGCTGAGAAGGCGATGGCTGAAGGACCAG
GAGCTGAGCCCTCGGGAGCCGGTGCTGCCCCCACAGAAGATGGGGCCTATGGAGAAATTCTGGAATAAATTTTTGGAGAATAAATCCCCT
TGGAGGAAAATGGTCCATGGGGTATACAAAAAGAGTATCTTTGTTTTCACTCATGTACTTGTACCTGTCTGGATTATTCATTATTACATG
AAGTATCATGTTTCTGAAAAACCATATGGCATAGTTGAAAAGAAGTCCAGAATATTCCCTGACTCCCAAATTCGTCAGAGCACAGCTTAT
AGCTTACATCAGCCTCAGGGAAACAAGGAACATGGGACCGAGCGGAACGGCAGCCTCTACAAGAAGAGTGACGGGATCCGAAAAGTGTGG
CAGAAAAGGAAATGTTCAGTTAAAAATGGTTTTCTGACCATATCCCATGGTACCGCTAACCGGCCTCCTGCAAAGCTCAACCTGCTAACC
TGCCAGGTGAAGACCAACCCTGAGGAGAAGAAGTGCTTTGACCTCATTTCACATGACAGAACTTACCACTTTCAAGCTGAAGATGAACAG
GAATGTCAAATATGGATGTCTGTGCTGCAAAATAGCAAAGAAGAAGCTTTAAACAATGCATTTAAGGGGGATGACAATACTGGAGAAAAT
AACATCGTCCAAGAACTGACAAAGGAGATCATCTCAGAAGTGCAGAGGATGACGGGCAATGACGTCTGCTGTGACTGTGGGGCGCCAGAT
CCTACATGGCTTTCCACCAACCTGGGCATCCTGACCTGCATCGAGTGTTCCGGAATCCACCGAGAGCTGGGGGTTCATTATTCCAGGATG
CAGTCCCTGACCTTAGATGTACTGGGAACATCTGAGCTGCTGCTCGCCAAGAATATTGGGAATGCAGGCTTTAATGAGATCATGGAATGT
TGCCTACCAGCTGAGGACTCAGTCAAACCCAACCCAGGCAGCGACATGAATGCAAGAAAGGACTACATCACAGCCAAGTACATCGAGAGG
AGATACGCAAGGAAGAAGCACGCGGATAACGCGGCGAAGCTTCACAGTCTTTGCGAGGCCGTCAAAACGAGAGATATTTTTGGATTGCTC
CAAGCTTATGCTGATGGTGTGGATCTTACGGAAAAAATCCCACTGGCCAACGGACATGAGCCGGATGAAACGGCCCTCCACCTTGCAGTC
AGATCCGTGGATCGAACCTCTCTTCACATTGTAGACTTTTTAGTTCAGAACAGTGGGAACCTGGATAAACAGACAGGGAAAGGCAGCACA
GCCCTGCACTACTGCTGCCTGACCGACAATGCCGAGTGCCTCAAGTTGCTCCTGCGGGGGAAGGCCTCCATCGAGATAGCAAACGAGTCA
GGAGAGACTCCGCTGGACATTGCCAAGCGCCTCAAGCACGAGCACTGTGAGGAGCTGCTGACCCAAGCCTTATCTGGAAGATTTAATTCT
CACGTTCACGTTGAATATGAATGGCGACTACTCCACGAAGACCTGGATGAAAGTGATGACGACATGGATGAGAAATTGCAGCCCAGTCCC
AACCGGCGGGAAGACCGGCCCATCAGCTTCTACCAGCTGGGCTCCAACCAGCTTCAGTCTAACGCTGTATCTTTGGCCAGAGATGCTGCA
AACCTTGCCAAGGAGAAGCAGAGGGCTTTCATGCCCAGCATCTTGCAGAATGAGACTTACGGAGCCCTCCTGAGTGGCAGCCCACCTCCC
GCCCAGCCTGCAGCCCCCAGCACCACCAGCGCCCCCCCGCTTCCTCCACGGAATGTTGGCAAAGATCCCCTGACCCCCACGCCGCCCCCA
CCCGTTGCCAAGACGCCCAGCGTAATGGAAGCCTTGAGCCAGCCGAGCAAGCCTGCCCCGCCTGGGATCTCACAGATCAGGCCCCCACCT
CTGCCCCCACAGCCGCCCAGCCGCCTCCCGCAGAAGAAGCCTGCGCCGGGGGCTGACAAGTCCACCCCACTGACCAACAAAGGCCAACCG
AGAGGACCTGTGGATCTCTCTGCAACGGAAGCTCTGGGTCCTCTGTCCAATGCTATGGTCCTGCAGCCCCCTGCACCCATGCCTAGGAAG
TCGCAGGCAACCAAGTTGAAGCCTAAGCGGGTGAAAGCGCTCTATAACTGTGTGGCTGACAACCCCGATGAGCTCACCTTCTCCGAGGGG
GATGTGATCATCGTGGACGGGGAGGAGGACCAGGAGTGGTGGATTGGCCACATTGATGGAGATCCTGGTCGCAAAGGCGCATTCCCGGTG
TCATTTGTGCACTTTATCGCTGACTGAATTGCTACTGAACAAAAGCATTAACAGTTATGTTCCTGTTTCGTTATTGGTACCAAAACTCTT
GCCAGATAACCAGTTTCATGAACTGTTTGTATGGCAGCCCATGTTCTCTAATGCCACTGCTCTGTTTTAAAAACTCAGAGGCAATTTTTA
CATATCAGTAATTGTTTTTATAATTTGTGGTTTTCATGAAACATTGCTATGCATTTATTAGGAAAAACTGAATTTCCCAACAGGTGAACT
GAAAAGTTATTTTAACTATTATACATAATCAAGATCCTGCCTCTACGGAATTAGCTAAACCTAAAAATGTTTGCATTAATGAATAAATTC
TTCCTGCATTCCTTGGCCCAGTTCTGGAGTTGGTGACCTTTATCACAATTATTATTTTAGGCGGCCAGTGAACTGCTGCTTCAGAAGTCC
ATAGCCCAGCTCTGAACTTTCTCGATAAAATGCCATCAGTTCACCTTTAAAGACACACATTCCTTTGAAATCCACCCAGTGTTTAAAAAG
CAACTTGGAAATTTACACATTAGCATTGTACTTTCTAGCCCTAATTTGTGAGGTTGCAGCTATCATTATATTCTGCATGTATGTATAACC
TGTTGTGAACAATCATACTTAACAAAACTACTGATGGTTTATGACAACGTAGGGTAACTACAGTTCATTCTGTTCCAGGTTATATAAAAC
TGCATTTCCTGAATTTGGTTAAAAACTAAGGATGATGGATTGCAAAACAGTTCTTTTAAATTAGTTTATATGCTTTAGGTGTTTTGGAAT
TTGCCTTCTTGAACTTCCTGAGTCACACAGAAAGCAACTGTACACAGTAGAATTCTGTGGCGCAGACCATGCTGTATTAACACATCACTT
GCTGTTTCCTACTGAGTGTACCACTGCCTTCCCTTCTAGCCCAGGAGAATGTTTACTCAGTTTAGTGTCTTGTATTTCTATAATACTCCA
ACAGGAATGGTAGTCACACTGTCTTGAAATTGAATCTGTCCATCTGTTTATAATCAAGAACATATCAGAAATATATAGGTCCCAGGTAAT
ACTCCCAAACATCCCACTTTTTACTGTTTCAGGCCATCATATCATTCTTAAGCTACTTGGGGTGGTAGTAGAGGATTAGGTTGTCTATTA
TAAAACCAAAACTCATTCGTTTAATGAACTTGACTGTCATACCTCTATTTAGTAATTGCGAGGGTAAGATTCATAGTAGGAATATTGGAA
ATTTTGGCACTCTGAGAATAAATAGGCATATGATACCCACTTGGACTTTTAACAAAAGTAAAGGAATAAATTTGCATATAGGCTTGGAAA
GTGAGGCAGCAATGCTGTTAACTGCATTTGTTGTGATGGTGCATTTGATTGAAGCAGCTTGTCTTTATTATGCAAGACTGTGTAGAGTTT
TTTTTTTTTTTGGCATTGTACTTTTTGTTTTTGTTATAAAGGAAGACAGAACAAACTGGAATGTTTTATGATGTTGTATAGCAATCGCTT
TTTACCTTTCAAAGTTCCGGGTAAAAATGTGTTATATCTGTAGTTTTTTGTTTTTGTTTTTTTTTAAAGCACTACATCTGTTTTCACTAA
TTGTTAATTTCTGTTTGAACCCTTCATTTAATTTTCTCATAGATTTAAGTAAACAGATGTATTTTGCACAGTGCACTTATGTCTATTTTA
ACAATCCTCCTGCATCTGTATTTTATAGTCAGCCTTTTGACCACCTGGTGCCAGCTATATAAGGAATAAAGTTGATTCATATCAACATTA
GAACTCCAGTCCCAAACTAATCTGTCAGGTTCACTGGTACATAAATACCTAGGAAATATTTTTCCAGTCTACAATTTGGTGCTATTGTGC
AGTAACTAATAGTACTCTTACCAGAGGAGAAATTATATTAACGACCCTGCTAATATCCTTTCTTAGTTATTTGCTCCTTGCAAATTAAAA
AAGCAACTAAGAGAAAGAAAAACATTGTAGATATCTATTTATATTTAAAGTTTATGTTTCATGAACTGCAGCTGCAGGATTCTGGCATTT
TGCATGCCATTCTCCATCAGATCTGGGATGATGGCTCAGAACATGTACACAGACTAAGAGTAACTGTGTGATCTGTTAAGGGGTGGATAA
CATAATATGCAGCTTAGGATGCTATTTTGAGATGTATGATATTCAGTTCATTCACCTGATTACTTTGGTTGCAGCACAACTGTATATATT
GTATAACCGAAATTGATTATTTTCATTGTCCTTAATGCAGTGATTTATAATTAGAGCATGTTTAATAAGTTTACTCTTCTTGTTAACTAG

>58188_58188_2_NDUFB6-ASAP2_NDUFB6_chr9_32558908_ENST00000379847_ASAP2_chr2_9484661_ENST00000315273_length(amino acids)=784AA_BP=103
MTGYTPDEKLRLQQLRELRRRWLKDQELSPREPVLPPQKMGPMEKFWNKFLENKSPWRKMVHGVYKKSIFVFTHVLVPVWIIHYYMKYHV
SEKPYGIVEKKSRIFPDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVK
TNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWL
STNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYAR
KKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHY
CCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRRE
DRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPSTTSAPPLPPRNVGKDPLTPTPPPPVAK
TPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQAT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NDUFB6-ASAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NDUFB6-ASAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NDUFB6-ASAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource