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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDUFS1-BRCA1 (FusionGDB2 ID:58219)

Fusion Gene Summary for NDUFS1-BRCA1

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFS1-BRCA1
Fusion gene ID: 58219
HgeneTgene
Gene symbol

NDUFS1

BRCA1

Gene ID

4719

672

Gene nameNADH:ubiquinone oxidoreductase core subunit S1BRCA1 DNA repair associated
SynonymsCI-75Kd|CI-75k|MC1DN5|PRO1304BRCAI|BRCC1|BROVCA1|FANCS|IRIS|PNCA4|PPP1R53|PSCP|RNF53
Cytomap

2q33.3

17q21.31

Type of geneprotein-codingprotein-coding
DescriptionNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)complex I 75kDa subunitcomplex I, mitochondrial respiratory chain, 75-kD subunitmitochondrial NADH-ubiquinone breast cancer type 1 susceptibility proteinBRCA1/BRCA2-containing complex, subunit 1Fanconi anemia, complementation group SRING finger protein 53breast and ovarian cancer susceptibility protein 1breast cancer 1, early onsetearly onset breast cancer
Modification date2020031320200329
UniProtAcc.

UIMC1

Ensembl transtripts involved in fusion geneENST00000233190, ENST00000432169, 
ENST00000440274, ENST00000449699, 
ENST00000455934, ENST00000423725, 
ENST00000457011, 		ENST00000471181, 
ENST00000491747, ENST00000493795, 
ENST00000586385, ENST00000591849, 
ENST00000309486, ENST00000346315, 
ENST00000351666, ENST00000352993, 
ENST00000354071, ENST00000357654, 
ENST00000468300, ENST00000591534, 
Fusion gene scores* DoF score8 X 7 X 3=1687 X 6 X 6=252
# samples 87
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFS1 [Title/Abstract] AND BRCA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDUFS1(207018341)-BRCA1(41209152), # samples:1
Anticipated loss of major functional domain due to fusion event.NDUFS1-BRCA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NDUFS1-BRCA1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
NDUFS1-BRCA1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
NDUFS1-BRCA1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNDUFS1

GO:0008637

apoptotic mitochondrial changes

15186778

TgeneBRCA1

GO:0000724

double-strand break repair via homologous recombination

17349954

TgeneBRCA1

GO:0006301

postreplication repair

17349954

TgeneBRCA1

GO:0006302

double-strand break repair

22186889

TgeneBRCA1

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

14654789

TgeneBRCA1

GO:0016567

protein ubiquitination

17349954

TgeneBRCA1

GO:0031398

positive regulation of protein ubiquitination

15965487

TgeneBRCA1

GO:0035066

positive regulation of histone acetylation

20820192

TgeneBRCA1

GO:0043627

response to estrogen

8895509

TgeneBRCA1

GO:0045892

negative regulation of transcription, DNA-templated

16288014

TgeneBRCA1

GO:0045893

positive regulation of transcription, DNA-templated

20160719

TgeneBRCA1

GO:0045944

positive regulation of transcription by RNA polymerase II

16331276

TgeneBRCA1

GO:0051571

positive regulation of histone H3-K4 methylation

20820192

TgeneBRCA1

GO:0051573

negative regulation of histone H3-K9 methylation

20820192

TgeneBRCA1

GO:0051865

protein autoubiquitination

12890688|20351172

TgeneBRCA1

GO:0070512

positive regulation of histone H4-K20 methylation

20820192

TgeneBRCA1

GO:0071158

positive regulation of cell cycle arrest

21102443

TgeneBRCA1

GO:0071681

cellular response to indole-3-methanol

10868478

TgeneBRCA1

GO:0085020

protein K6-linked ubiquitination

12890688|20351172

TgeneBRCA1

GO:2000617

positive regulation of histone H3-K9 acetylation

20820192

TgeneBRCA1

GO:2000620

positive regulation of histone H4-K16 acetylation

20820192


check buttonFusion gene breakpoints across NDUFS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRCA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-4735NDUFS1chr2

207018341

-BRCA1chr17

41209152

-


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Fusion Gene ORF analysis for NDUFS1-BRCA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000233190ENST00000471181NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000233190ENST00000491747NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000233190ENST00000493795NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000233190ENST00000586385NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000233190ENST00000591849NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000432169ENST00000471181NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000432169ENST00000491747NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000432169ENST00000493795NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000432169ENST00000586385NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000432169ENST00000591849NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000440274ENST00000471181NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000440274ENST00000491747NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000440274ENST00000493795NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000440274ENST00000586385NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000440274ENST00000591849NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000449699ENST00000471181NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000449699ENST00000491747NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000449699ENST00000493795NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000449699ENST00000586385NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000449699ENST00000591849NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000455934ENST00000471181NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000455934ENST00000491747NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000455934ENST00000493795NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000455934ENST00000586385NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5CDS-intronENST00000455934ENST00000591849NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-3CDSENST00000423725ENST00000309486NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-3CDSENST00000423725ENST00000346315NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-3CDSENST00000423725ENST00000351666NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-3CDSENST00000423725ENST00000352993NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-3CDSENST00000423725ENST00000354071NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-3CDSENST00000423725ENST00000357654NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-3CDSENST00000423725ENST00000468300NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-3CDSENST00000423725ENST00000591534NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-intronENST00000423725ENST00000471181NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-intronENST00000423725ENST00000491747NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-intronENST00000423725ENST00000493795NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-intronENST00000423725ENST00000586385NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
5UTR-intronENST00000423725ENST00000591849NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000233190ENST00000309486NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000233190ENST00000346315NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000233190ENST00000351666NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000233190ENST00000352993NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000233190ENST00000354071NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000233190ENST00000357654NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000233190ENST00000468300NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000233190ENST00000591534NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000432169ENST00000309486NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000432169ENST00000346315NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000432169ENST00000351666NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000432169ENST00000352993NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000432169ENST00000354071NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000432169ENST00000357654NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000432169ENST00000468300NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000432169ENST00000591534NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000440274ENST00000309486NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000440274ENST00000346315NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000440274ENST00000351666NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000440274ENST00000352993NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000440274ENST00000354071NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000440274ENST00000357654NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000440274ENST00000468300NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000440274ENST00000591534NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000455934ENST00000309486NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000455934ENST00000346315NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000455934ENST00000351666NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000455934ENST00000352993NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000455934ENST00000354071NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000455934ENST00000357654NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000455934ENST00000468300NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
Frame-shiftENST00000455934ENST00000591534NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
In-frameENST00000449699ENST00000309486NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
In-frameENST00000449699ENST00000346315NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
In-frameENST00000449699ENST00000351666NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
In-frameENST00000449699ENST00000352993NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
In-frameENST00000449699ENST00000354071NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
In-frameENST00000449699ENST00000357654NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
In-frameENST00000449699ENST00000468300NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
In-frameENST00000449699ENST00000591534NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-3CDSENST00000457011ENST00000309486NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-3CDSENST00000457011ENST00000346315NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-3CDSENST00000457011ENST00000351666NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-3CDSENST00000457011ENST00000352993NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-3CDSENST00000457011ENST00000354071NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-3CDSENST00000457011ENST00000357654NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-3CDSENST00000457011ENST00000468300NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-3CDSENST00000457011ENST00000591534NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-intronENST00000457011ENST00000471181NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-intronENST00000457011ENST00000491747NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-intronENST00000457011ENST00000493795NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-intronENST00000457011ENST00000586385NDUFS1chr2

207018341

-BRCA1chr17

41209152

-
intron-intronENST00000457011ENST00000591849NDUFS1chr2

207018341

-BRCA1chr17

41209152

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000449699NDUFS1chr2207018341-ENST00000357654BRCA1chr1741209152-1946164697359112
ENST00000449699NDUFS1chr2207018341-ENST00000351666BRCA1chr1741209152-1945164697359112
ENST00000449699NDUFS1chr2207018341-ENST00000309486BRCA1chr1741209152-1945164697359112
ENST00000449699NDUFS1chr2207018341-ENST00000346315BRCA1chr1741209152-1945164697359112
ENST00000449699NDUFS1chr2207018341-ENST00000354071BRCA1chr1741209152-1945164697359112
ENST00000449699NDUFS1chr2207018341-ENST00000352993BRCA1chr1741209152-1945164697359112
ENST00000449699NDUFS1chr2207018341-ENST00000468300BRCA1chr1741209152-1362164623285112
ENST00000449699NDUFS1chr2207018341-ENST00000591534BRCA1chr1741209152-67816465535998

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000449699ENST00000357654NDUFS1chr2207018341-BRCA1chr1741209152-0.611301060.3886989
ENST00000449699ENST00000351666NDUFS1chr2207018341-BRCA1chr1741209152-0.60608190.3939181
ENST00000449699ENST00000309486NDUFS1chr2207018341-BRCA1chr1741209152-0.60608190.3939181
ENST00000449699ENST00000346315NDUFS1chr2207018341-BRCA1chr1741209152-0.60608190.3939181
ENST00000449699ENST00000354071NDUFS1chr2207018341-BRCA1chr1741209152-0.60608190.3939181
ENST00000449699ENST00000352993NDUFS1chr2207018341-BRCA1chr1741209152-0.60608190.3939181
ENST00000449699ENST00000468300NDUFS1chr2207018341-BRCA1chr1741209152-0.76656880.23343128
ENST00000449699ENST00000591534NDUFS1chr2207018341-BRCA1chr1741209152-0.378391440.6216085

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Fusion Genomic Features for NDUFS1-BRCA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDUFS1-BRCA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:207018341/chr17:41209152)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BRCA1

UIMC1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.719

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRCA1chr2:207018341chr17:41209152ENST000003529931622651_654589722.0Compositional biasNote=Poly-Lys
TgeneBRCA1chr2:207018341chr17:41209152ENST000004683001722651_654627700.0Compositional biasNote=Poly-Lys
TgeneBRCA1chr2:207018341chr17:41209152ENST000004917471723651_654627760.0Compositional biasNote=Poly-Lys
TgeneBRCA1chr2:207018341chr17:41209152ENST0000035299316221642_1736589722.0DomainBRCT 1
TgeneBRCA1chr2:207018341chr17:41209152ENST0000035299316221756_1855589722.0DomainBRCT 2
TgeneBRCA1chr2:207018341chr17:41209152ENST0000035765417231756_185517311864.0DomainBRCT 2
TgeneBRCA1chr2:207018341chr17:41209152ENST0000046830017221642_1736627700.0DomainBRCT 1
TgeneBRCA1chr2:207018341chr17:41209152ENST0000046830017221756_1855627700.0DomainBRCT 2
TgeneBRCA1chr2:207018341chr17:41209152ENST0000049174717231642_1736627760.0DomainBRCT 1
TgeneBRCA1chr2:207018341chr17:41209152ENST0000049174717231756_1855627760.0DomainBRCT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000233190-219108_14720728.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000233190-219245_30120728.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000233190-21930_10820728.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000423725-218108_1470671.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000423725-218245_3010671.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000423725-21830_1080671.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000432169-216108_1471617.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000432169-216245_3011617.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000432169-21630_1081617.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000440274-218108_14720692.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000440274-218245_30120692.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000440274-21830_10820692.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000449699-219108_14720728.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000449699-219245_30120728.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000449699-21930_10820728.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000455934-219108_14734742.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000455934-219245_30134742.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr17:41209152ENST00000455934-21930_10834742.0Domain2Fe-2S ferredoxin-type
TgeneBRCA1chr2:207018341chr17:41209152ENST000003576541723651_65417311864.0Compositional biasNote=Poly-Lys
TgeneBRCA1chr2:207018341chr17:41209152ENST0000035765417231642_173617311864.0DomainBRCT 1
TgeneBRCA1chr2:207018341chr17:41209152ENST00000352993162224_65589722.0Zinc fingerRING-type
TgeneBRCA1chr2:207018341chr17:41209152ENST00000357654172324_6517311864.0Zinc fingerRING-type
TgeneBRCA1chr2:207018341chr17:41209152ENST00000468300172224_65627700.0Zinc fingerRING-type
TgeneBRCA1chr2:207018341chr17:41209152ENST00000491747172324_65627760.0Zinc fingerRING-type


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Fusion Gene Sequence for NDUFS1-BRCA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58219_58219_1_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000309486_length(transcript)=1945nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGCATGATTTTGAAGTCA
GAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCT
GTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCAT
CATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGA
TGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCC
AGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGG
CCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTAT
GCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGAT
TTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTA
GGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAG
AGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAG
TGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCA
GCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAA
AATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGG
TGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAA
AATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAA
CCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAA
AATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTT
TTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTAT
CCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACG

>58219_58219_1_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000309486_length(amino acids)=112AA_BP=
MMYIKYLVARTVEGLKSERSSQGLERPLCKLILGVLWLCTCGWLQSVVAVGDLGYQVGVQLLALVECYTVQHPLSGHHRCLTHLPNCMEA

--------------------------------------------------------------
>58219_58219_2_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000346315_length(transcript)=1945nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGCATGATTTTGAAGTCA
GAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCT
GTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCAT
CATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGA
TGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCC
AGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGG
CCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTAT
GCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGAT
TTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTA
GGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAG
AGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAG
TGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCA
GCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAA
AATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGG
TGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAA
AATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAA
CCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAA
AATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTT
TTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTAT
CCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACG

>58219_58219_2_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000346315_length(amino acids)=112AA_BP=
MMYIKYLVARTVEGLKSERSSQGLERPLCKLILGVLWLCTCGWLQSVVAVGDLGYQVGVQLLALVECYTVQHPLSGHHRCLTHLPNCMEA

--------------------------------------------------------------
>58219_58219_3_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000351666_length(transcript)=1945nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGCATGATTTTGAAGTCA
GAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCT
GTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCAT
CATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGA
TGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCC
AGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGG
CCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTAT
GCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGAT
TTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTA
GGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAG
AGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAG
TGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCA
GCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAA
AATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGG
TGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAA
AATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAA
CCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAA
AATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTT
TTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTAT
CCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACG

>58219_58219_3_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000351666_length(amino acids)=112AA_BP=
MMYIKYLVARTVEGLKSERSSQGLERPLCKLILGVLWLCTCGWLQSVVAVGDLGYQVGVQLLALVECYTVQHPLSGHHRCLTHLPNCMEA

--------------------------------------------------------------
>58219_58219_4_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000352993_length(transcript)=1945nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGCATGATTTTGAAGTCA
GAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCT
GTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCAT
CATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGA
TGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCC
AGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGG
CCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTAT
GCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGAT
TTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTA
GGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAG
AGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAG
TGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCA
GCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAA
AATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGG
TGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAA
AATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAA
CCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAA
AATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTT
TTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTAT
CCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACG

>58219_58219_4_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000352993_length(amino acids)=112AA_BP=
MMYIKYLVARTVEGLKSERSSQGLERPLCKLILGVLWLCTCGWLQSVVAVGDLGYQVGVQLLALVECYTVQHPLSGHHRCLTHLPNCMEA

--------------------------------------------------------------
>58219_58219_5_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000354071_length(transcript)=1945nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGCATGATTTTGAAGTCA
GAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCT
GTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCAT
CATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGA
TGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCC
AGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGG
CCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTAT
GCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGAT
TTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTA
GGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAG
AGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAG
TGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCA
GCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAA
AATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGG
TGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAA
AATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAA
CCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAA
AATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTT
TTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTAT
CCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACG

>58219_58219_5_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000354071_length(amino acids)=112AA_BP=
MMYIKYLVARTVEGLKSERSSQGLERPLCKLILGVLWLCTCGWLQSVVAVGDLGYQVGVQLLALVECYTVQHPLSGHHRCLTHLPNCMEA

--------------------------------------------------------------
>58219_58219_6_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000357654_length(transcript)=1946nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGCATGATTTTGAAGTCA
GAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCT
GTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCAT
CATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGA
TGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCC
AGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGG
CCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAAAAGGACTTCTGGCTAT
GCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATTTTTCACCTGAGAAGAT
TTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCAGGCTGTTGTTGGCTTA
GGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGTGTTCACAAAGGCAGAG
AGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAGTTCTCAAATGTTGGAG
TGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCTCACGCCTGTAATCCCA
GCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAACCCCATCTCTACTAAA
AATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATCACTTCAGCCCGGGAGG
TGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAAAAAAAAAAAAAAGGAA
AATGAAACTAGAAGAGATTTCTAAAAGTCTGAGATATATTTGCTAGATTTCTAAAGAATGTGTTCTAAAACAGCAGAAGATTTTCAAGAA
CCGGTTTCCAAAGACAGTCTTCTAATTCCTCATTAGTAATAAGTAAAATGTTTATTGTTGTAGCTCTGGTATATAATCCATTCCTCTTAA
AATATAAGACCTCTGGCATGAATATTTCATATCTATAAAATGACAGATCCCACCAGGAAGGAAGCTGTTGCTTTCTTTGAGGTGATTTTT
TTCCTTTGCTCCCTGTTGCTGAAACCATACAGCTTCATAAATAATTTTGCTTGCTGAAGGAAGAAAAAGTGTTTTTCATAAACCCATTAT
CCAGGACTGTTTATAGCTGTTGGAAGGACTAGGTCTTCCCTAGCCCCCCCAGTGTGCAAGGGCAGTGAAGACTTGATTGTACAAAATACG

>58219_58219_6_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000357654_length(amino acids)=112AA_BP=
MMYIKYLVARTVEGLKSERSSQGLERPLCKLILGVLWLCTCGWLQSVVAVGDLGYQVGVQLLALVECYTVQHPLSGHHRCLTHLPNCMEA

--------------------------------------------------------------
>58219_58219_7_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000468300_length(transcript)=1362nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGCATGATTTTGAAGTCA
GAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCT
GTTGCTATGGGCCCTTCACCAACATGCCCACAGGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTC
CATGCAATTGGGCAGATGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGAC
ACCTACCTGATACCCCAGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACA
AAGTGGCCTTTCCAGGCCCTGGGAGCTCCTCTCACTCTTCAGTCCTTCTACTGTCCTGGCTACTAAATATTTTATGTACATCAGCCTGAA
AAGGACTTCTGGCTATGCAAGGGTCCCTTAAAGATTTTCTGCTTGAAGTCTCCCTTGGAAATCTGCCATGAGCACAAAATTATGGTAATT
TTTCACCTGAGAAGATTTTAAAACCATTTAAACGCCACCAATTGAGCAAGATGCTGATTCATTATTTATCAGCCCTATTCTTTCTATTCA
GGCTGTTGTTGGCTTAGGGCTGGAAGCACAGAGTGGCTTGGCCTCAAGAGAATAGCTGGTTTCCCTAAGTTTACTTCTCTAAAACCCTGT
GTTCACAAAGGCAGAGAGTCAGACCCTTCAATGGAAGGAGAGTGCTTGGGATCGATTATGTGACTTAAAGTCAGAATAGTCCTTGGGCAG
TTCTCAAATGTTGGAGTGGAACATTGGGGAGGAAATTCTGAGGCAGGTATTAGAAATGAAAAGGAAACTTGAAACCTGGGCATGGTGGCT
CACGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGTGGGCAGATCACTGGAGGTCAGGAGTTCGAAACCAGCCTGGCCAACATGGTGAAA
CCCCATCTCTACTAAAAATACAGAAATTAGCCGGTCATGGTGGTGGACACCTGTAATCCCAGCTACTCAGGTGGCTAAGGCAGGAGAATC
ACTTCAGCCCGGGAGGTGGAGGTTGCAGTGAGCCAAGATCATACCACGGCACTCCAGCCTGGGTGACAGTGAGACTGTGGCTCAAAAAAA

>58219_58219_7_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000468300_length(amino acids)=112AA_BP=
MMYIKYLVARTVEGLKSERSSQGLERPLCKLILGVLWLCTCGWLQSVVAVGDLGYQVGVQLLALVECYTVQHPLSGHHRCLTHLPNCMEA

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>58219_58219_8_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000591534_length(transcript)=678nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGCATGATTTTGAAGTCA
GAGGAGATGTGGTCAATGGAAGAAACCACCAAGGTCCAAAGCGAGCAAGAGAATCCCAGGACAGAAAGATCTTCAGGGGGCTAGAAATCT
GTTGCTATGGGCCCTTCACCAACATGCCCACAGATCAACTGGAATGGATGGTACAGCTGTGTGGTGCTTCTGTGGTGAAGGAGCTTTCAT
CATTCACCCTTGGCACAGGTGTCCACCCAATTGTGGTTGTGCAGCCAGATGCCTGGACAGAGGACAATGGCTTCCATGCAATTGGGCAGA
TGTGTGAGGCACCTGTGGTGACCCGAGAGTGGGTGTTGGACAGTGTAGCACTCTACCAGTGCCAGGAGCTGGACACCTACCTGATACCCC
AGATCCCCCACAGCCACTACTGACTGCAGCCAGCCACAGGTACAGAGCCACAGGACCCCAAGAATGAGCTTACAAAGTGGCCTTTCCAGG

>58219_58219_8_NDUFS1-BRCA1_NDUFS1_chr2_207018341_ENST00000449699_BRCA1_chr17_41209152_ENST00000591534_length(amino acids)=98AA_BP=
MKSERSSQGLERPLCKLILGVLWLCTCGWLQSVVAVGDLGYQVGVQLLALVECYTVQHPLSGHHRCLTHLPNCMEAIVLCPGIWLHNHNW

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Fusion Gene PPI Analysis for NDUFS1-BRCA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneBRCA1chr2:207018341chr17:41209152ENST0000035299316221397_1424589.0722.0PALB2
TgeneBRCA1chr2:207018341chr17:41209152ENST0000046830017221397_1424627.0700.0PALB2
TgeneBRCA1chr2:207018341chr17:41209152ENST0000049174717231397_1424627.0760.0PALB2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneBRCA1chr2:207018341chr17:41209152ENST0000035765417231397_14241731.01864.0PALB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDUFS1-BRCA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDUFS1-BRCA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource