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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NDUFS1-RBM39 (FusionGDB2 ID:58225)

Fusion Gene Summary for NDUFS1-RBM39

check button Fusion gene summary
Fusion gene informationFusion gene name: NDUFS1-RBM39
Fusion gene ID: 58225
HgeneTgene
Gene symbol

NDUFS1

RBM39

Gene ID

4719

9584

Gene nameNADH:ubiquinone oxidoreductase core subunit S1RNA binding motif protein 39
SynonymsCI-75Kd|CI-75k|MC1DN5|PRO1304CAPER|CAPERalpha|FSAP59|HCC1|RNPC2
Cytomap

2q33.3

20q11.22

Type of geneprotein-codingprotein-coding
DescriptionNADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrialNADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)complex I 75kDa subunitcomplex I, mitochondrial respiratory chain, 75-kD subunitmitochondrial NADH-ubiquinone RNA-binding protein 39CAPER alphaRNA-binding region (RNP1, RRM) containing 2coactivator of activating protein-1 and estrogen receptorsepididymis secretory sperm binding proteinfunctional spliceosome-associated protein 59hepatocellular carcinoma prot
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000233190, ENST00000432169, 
ENST00000440274, ENST00000449699, 
ENST00000455934, ENST00000423725, 
ENST00000457011, 		ENST00000397370, 
ENST00000463098, ENST00000253363, 
ENST00000361162, ENST00000407261, 
ENST00000528062, 
Fusion gene scores* DoF score8 X 7 X 3=16824 X 16 X 12=4608
# samples 827
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/4608*10)=-4.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NDUFS1 [Title/Abstract] AND RBM39 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNDUFS1(207018341)-RBM39(34301018), # samples:1
Anticipated loss of major functional domain due to fusion event.NDUFS1-RBM39 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NDUFS1-RBM39 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNDUFS1

GO:0008637

apoptotic mitochondrial changes

15186778


check buttonFusion gene breakpoints across NDUFS1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RBM39 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-G4-6320NDUFS1chr2

207018341

-RBM39chr20

34301018

-


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Fusion Gene ORF analysis for NDUFS1-RBM39

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000233190ENST00000397370NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000233190ENST00000463098NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000432169ENST00000397370NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000432169ENST00000463098NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000440274ENST00000397370NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000440274ENST00000463098NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000449699ENST00000397370NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000449699ENST00000463098NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000455934ENST00000397370NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5CDS-intronENST00000455934ENST00000463098NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5UTR-3CDSENST00000423725ENST00000253363NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5UTR-3CDSENST00000423725ENST00000361162NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5UTR-3CDSENST00000423725ENST00000407261NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5UTR-3CDSENST00000423725ENST00000528062NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5UTR-intronENST00000423725ENST00000397370NDUFS1chr2

207018341

-RBM39chr20

34301018

-
5UTR-intronENST00000423725ENST00000463098NDUFS1chr2

207018341

-RBM39chr20

34301018

-
Frame-shiftENST00000432169ENST00000253363NDUFS1chr2

207018341

-RBM39chr20

34301018

-
Frame-shiftENST00000432169ENST00000361162NDUFS1chr2

207018341

-RBM39chr20

34301018

-
Frame-shiftENST00000432169ENST00000407261NDUFS1chr2

207018341

-RBM39chr20

34301018

-
Frame-shiftENST00000432169ENST00000528062NDUFS1chr2

207018341

-RBM39chr20

34301018

-
Frame-shiftENST00000449699ENST00000253363NDUFS1chr2

207018341

-RBM39chr20

34301018

-
Frame-shiftENST00000449699ENST00000361162NDUFS1chr2

207018341

-RBM39chr20

34301018

-
Frame-shiftENST00000449699ENST00000407261NDUFS1chr2

207018341

-RBM39chr20

34301018

-
Frame-shiftENST00000449699ENST00000528062NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000233190ENST00000253363NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000233190ENST00000361162NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000233190ENST00000407261NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000233190ENST00000528062NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000440274ENST00000253363NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000440274ENST00000361162NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000440274ENST00000407261NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000440274ENST00000528062NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000455934ENST00000253363NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000455934ENST00000361162NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000455934ENST00000407261NDUFS1chr2

207018341

-RBM39chr20

34301018

-
In-frameENST00000455934ENST00000528062NDUFS1chr2

207018341

-RBM39chr20

34301018

-
intron-3CDSENST00000457011ENST00000253363NDUFS1chr2

207018341

-RBM39chr20

34301018

-
intron-3CDSENST00000457011ENST00000361162NDUFS1chr2

207018341

-RBM39chr20

34301018

-
intron-3CDSENST00000457011ENST00000407261NDUFS1chr2

207018341

-RBM39chr20

34301018

-
intron-3CDSENST00000457011ENST00000528062NDUFS1chr2

207018341

-RBM39chr20

34301018

-
intron-intronENST00000457011ENST00000397370NDUFS1chr2

207018341

-RBM39chr20

34301018

-
intron-intronENST00000457011ENST00000463098NDUFS1chr2

207018341

-RBM39chr20

34301018

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000233190NDUFS1chr2207018341-ENST00000253363RBM39chr2034301018-1696328267824185
ENST00000233190NDUFS1chr2207018341-ENST00000361162RBM39chr2034301018-1678328267806179
ENST00000233190NDUFS1chr2207018341-ENST00000528062RBM39chr2034301018-1408328267824185
ENST00000233190NDUFS1chr2207018341-ENST00000407261RBM39chr2034301018-978328267824185
ENST00000440274NDUFS1chr2207018341-ENST00000253363RBM39chr2034301018-151815089646185
ENST00000440274NDUFS1chr2207018341-ENST00000361162RBM39chr2034301018-150015089628179
ENST00000440274NDUFS1chr2207018341-ENST00000528062RBM39chr2034301018-123015089646185
ENST00000440274NDUFS1chr2207018341-ENST00000407261RBM39chr2034301018-80015089646185
ENST00000455934NDUFS1chr2207018341-ENST00000253363RBM39chr2034301018-153216461660199
ENST00000455934NDUFS1chr2207018341-ENST00000361162RBM39chr2034301018-151416461642193
ENST00000455934NDUFS1chr2207018341-ENST00000528062RBM39chr2034301018-124416461660199
ENST00000455934NDUFS1chr2207018341-ENST00000407261RBM39chr2034301018-81416461660199

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000233190ENST00000253363NDUFS1chr2207018341-RBM39chr2034301018-0.0004530750.99954695
ENST00000233190ENST00000361162NDUFS1chr2207018341-RBM39chr2034301018-0.0008508740.9991491
ENST00000233190ENST00000528062NDUFS1chr2207018341-RBM39chr2034301018-0.000571640.99942833
ENST00000233190ENST00000407261NDUFS1chr2207018341-RBM39chr2034301018-0.0010133180.99898666
ENST00000440274ENST00000253363NDUFS1chr2207018341-RBM39chr2034301018-0.0006852350.9993148
ENST00000440274ENST00000361162NDUFS1chr2207018341-RBM39chr2034301018-0.0012729460.998727
ENST00000440274ENST00000528062NDUFS1chr2207018341-RBM39chr2034301018-0.0007600140.99924004
ENST00000440274ENST00000407261NDUFS1chr2207018341-RBM39chr2034301018-0.0012259870.998774
ENST00000455934ENST00000253363NDUFS1chr2207018341-RBM39chr2034301018-0.0020095930.99799037
ENST00000455934ENST00000361162NDUFS1chr2207018341-RBM39chr2034301018-0.0028359350.9971641
ENST00000455934ENST00000528062NDUFS1chr2207018341-RBM39chr2034301018-0.0021687720.99783117
ENST00000455934ENST00000407261NDUFS1chr2207018341-RBM39chr2034301018-0.0034890930.9965109

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Fusion Genomic Features for NDUFS1-RBM39


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NDUFS1-RBM39


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:207018341/chr20:34301018)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRBM39chr2:207018341chr20:34301018ENST000002533631017409_416365531.0Compositional biasNote=Poly-Ala
TgeneRBM39chr2:207018341chr20:34301018ENST000003611621017409_416365525.0Compositional biasNote=Poly-Ala
TgeneRBM39chr2:207018341chr20:34301018ENST00000528062916409_416343509.0Compositional biasNote=Poly-Ala
TgeneRBM39chr2:207018341chr20:34301018ENST000002533631017445_508365531.0DomainRRM 3
TgeneRBM39chr2:207018341chr20:34301018ENST000003611621017445_508365525.0DomainRRM 3
TgeneRBM39chr2:207018341chr20:34301018ENST00000528062916445_508343509.0DomainRRM 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000233190-219108_14720728.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000233190-219245_30120728.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000233190-21930_10820728.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000423725-218108_1470671.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000423725-218245_3010671.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000423725-21830_1080671.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000432169-216108_1471617.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000432169-216245_3011617.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000432169-21630_1081617.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000440274-218108_14720692.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000440274-218245_30120692.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000440274-21830_10820692.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000449699-219108_14720728.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000449699-219245_30120728.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000449699-21930_10820728.0Domain2Fe-2S ferredoxin-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000455934-219108_14734742.0Domain4Fe-4S His(Cys)3-ligated-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000455934-219245_30134742.0Domain4Fe-4S Mo/W bis-MGD-type
HgeneNDUFS1chr2:207018341chr20:34301018ENST00000455934-21930_10834742.0Domain2Fe-2S ferredoxin-type
TgeneRBM39chr2:207018341chr20:34301018ENST00000253363101741_90365531.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr2:207018341chr20:34301018ENST00000361162101741_90365525.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr2:207018341chr20:34301018ENST0000052806291641_90343509.0Compositional biasNote=Arg/Ser-rich (RS domain)
TgeneRBM39chr2:207018341chr20:34301018ENST000002533631017153_230365531.0DomainRRM 1
TgeneRBM39chr2:207018341chr20:34301018ENST000002533631017250_328365531.0DomainRRM 2
TgeneRBM39chr2:207018341chr20:34301018ENST000003611621017153_230365525.0DomainRRM 1
TgeneRBM39chr2:207018341chr20:34301018ENST000003611621017250_328365525.0DomainRRM 2
TgeneRBM39chr2:207018341chr20:34301018ENST00000528062916153_230343509.0DomainRRM 1
TgeneRBM39chr2:207018341chr20:34301018ENST00000528062916250_328343509.0DomainRRM 2
TgeneRBM39chr2:207018341chr20:34301018ENST000002533631017291_355365531.0RegionActivating domain
TgeneRBM39chr2:207018341chr20:34301018ENST000003611621017291_355365525.0RegionActivating domain
TgeneRBM39chr2:207018341chr20:34301018ENST00000528062916291_355343509.0RegionActivating domain


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Fusion Gene Sequence for NDUFS1-RBM39


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58225_58225_1_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000233190_RBM39_chr20_34301018_ENST00000253363_length(transcript)=1696nt_BP=328nt
CACTTCCGGCGGAACTGCGGGTCCAAGTTGTCCTTCCCGCCTCCGGGCTGGGCCGACCTCAGCTCCGCCCTCTGGTCGGCTGACGGAAAT
TGCCGACAAACTTGTCGAATGCAAGGATTCTAGTCCCTCCGGGCTTTCCGTTCTCCAGGCCCGGCTGACAGAGTTAGCCGAGGCCGCCAT
ATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATATG
TTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCACAG
CAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAG
ACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACA
GAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGAC
AAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTT
GCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTT
CCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGA
TAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGC
TCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTA
TAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTT
ACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATA
CAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGA
TGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCC
TGCATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGG
TTGCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATAT

>58225_58225_1_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000233190_RBM39_chr20_34301018_ENST00000253363_length(amino acids)=185AA_BP=20
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>58225_58225_2_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000233190_RBM39_chr20_34301018_ENST00000361162_length(transcript)=1678nt_BP=328nt
CACTTCCGGCGGAACTGCGGGTCCAAGTTGTCCTTCCCGCCTCCGGGCTGGGCCGACCTCAGCTCCGCCCTCTGGTCGGCTGACGGAAAT
TGCCGACAAACTTGTCGAATGCAAGGATTCTAGTCCCTCCGGGCTTTCCGTTCTCCAGGCCCGGCTGACAGAGTTAGCCGAGGCCGCCAT
ATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATATG
TTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCACAG
CAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTA
GCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAAGAAGTTGGATGG
GATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAATTCAGCTCAGGGC
AATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGTAAAATGATAACA
GCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGTAGACGATGAAGG
AAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAATAAAGAGGCAAG
GATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTCTCCCTAAATAGT
AAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAATAGCTCTAGGAG
AACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAGTGGTTACATTTC
ACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGACAGCTAAAGGGCT
GTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTATCTTTTCAATTAA
TGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTGCATTTCCTGAAGATGT
TTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTTGCATATAATCTTTGCT
CTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTTCTATCAAACAAATGAC

>58225_58225_2_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000233190_RBM39_chr20_34301018_ENST00000361162_length(amino acids)=179AA_BP=20
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVG

--------------------------------------------------------------
>58225_58225_3_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000233190_RBM39_chr20_34301018_ENST00000407261_length(transcript)=978nt_BP=328nt
CACTTCCGGCGGAACTGCGGGTCCAAGTTGTCCTTCCCGCCTCCGGGCTGGGCCGACCTCAGCTCCGCCCTCTGGTCGGCTGACGGAAAT
TGCCGACAAACTTGTCGAATGCAAGGATTCTAGTCCCTCCGGGCTTTCCGTTCTCCAGGCCCGGCTGACAGAGTTAGCCGAGGCCGCCAT
ATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATATG
TTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCACAG
CAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAG
ACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACA
GAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGAC
AAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTT
GCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTT
CCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGA

>58225_58225_3_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000233190_RBM39_chr20_34301018_ENST00000407261_length(amino acids)=185AA_BP=20
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>58225_58225_4_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000233190_RBM39_chr20_34301018_ENST00000528062_length(transcript)=1408nt_BP=328nt
CACTTCCGGCGGAACTGCGGGTCCAAGTTGTCCTTCCCGCCTCCGGGCTGGGCCGACCTCAGCTCCGCCCTCTGGTCGGCTGACGGAAAT
TGCCGACAAACTTGTCGAATGCAAGGATTCTAGTCCCTCCGGGCTTTCCGTTCTCCAGGCCCGGCTGACAGAGTTAGCCGAGGCCGCCAT
ATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATATG
TTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCACAG
CAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGCAG
ACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACA
GAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGAC
AAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTT
GCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTT
CCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGA
TAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGC
TCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTA
TAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTT
ACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATA
CAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGA

>58225_58225_4_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000233190_RBM39_chr20_34301018_ENST00000528062_length(amino acids)=185AA_BP=20
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>58225_58225_5_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000440274_RBM39_chr20_34301018_ENST00000253363_length(transcript)=1518nt_BP=150nt
ATATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATA
TGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCAC
AGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGC
AGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAA
CAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTG
ACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGT
TTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGG
TTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTA
GATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGT
GCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAAC
TATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTT
TTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAA
TACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTT
GATGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATC
CCTGCATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCT
GGTTGCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGAT

>58225_58225_5_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000440274_RBM39_chr20_34301018_ENST00000253363_length(amino acids)=185AA_BP=20
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>58225_58225_6_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000440274_RBM39_chr20_34301018_ENST00000361162_length(transcript)=1500nt_BP=150nt
ATATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATA
TGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCAC
AGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGCAGACTGAAGCTTCAGCTT
TAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGAAGAAGAAGTTGGAT
GGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAAAAATTCAGCTCAGG
GCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGCTGGTAAAATGATAA
CAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCCAAGTAGACGATGAA
GGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATAAAAATAAAGAGGCA
AGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTCATTCTCCCTAAATA
GTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATAGGAATAGCTCTAGG
AGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTACACAGTGGTTACATT
TCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACAAGACAGCTAAAGGG
CTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATGGTATCTTTTCAATT
AATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTGCATTTCCTGAAGAT
GTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTTGCATATAATCTTTG
CTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTTCTATCAAACAAATG

>58225_58225_6_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000440274_RBM39_chr20_34301018_ENST00000361162_length(amino acids)=179AA_BP=20
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVG

--------------------------------------------------------------
>58225_58225_7_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000440274_RBM39_chr20_34301018_ENST00000407261_length(transcript)=800nt_BP=150nt
ATATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATA
TGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCAC
AGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGC
AGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAA
CAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTG
ACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGT
TTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGG
TTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTA

>58225_58225_7_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000440274_RBM39_chr20_34301018_ENST00000407261_length(amino acids)=185AA_BP=20
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>58225_58225_8_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000440274_RBM39_chr20_34301018_ENST00000528062_length(transcript)=1230nt_BP=150nt
ATATTGAATAAGCGACCCGGCCTCCTAGGGGGTCGTCGTGGTCCAGACAGTTTAGCAGAACAGCCTCCGCGGCTCCGGGGAGAAGCAATA
TGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGATTCCGCCAGCAGCAC
AGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAACAAGACTTTCCCAGC
AGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAA
CAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTG
ACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGT
TTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGG
TTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTA
GATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGT
GCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAAC
TATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTT
TTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAA
TACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTT

>58225_58225_8_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000440274_RBM39_chr20_34301018_ENST00000528062_length(amino acids)=185AA_BP=20
MLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQ
TEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLL

--------------------------------------------------------------
>58225_58225_9_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000455934_RBM39_chr20_34301018_ENST00000253363_length(transcript)=1532nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAAC
AAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACAT
GTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTAT
TCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATT
GCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGC
AACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAG
TTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAA
CAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTA
GAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTC
AGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACAT
TTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCA
AAATTATATTTCTTGATGGTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTC
CAAACAAAATGATCCCTGCATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGA
AATAGGTTTTGTCTGGTTGCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGA
CAAGACAGCTTGATATTTCTATCAAACAAATGACTTTCATATTGCAACAATCTTTGTAAGAACCACTCAAATAAAAGTCTCTTAAAAAGG

>58225_58225_9_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000455934_RBM39_chr20_34301018_ENST00000253363_length(amino acids)=199AA_BP=34
MRIRGSSGTLSRINMLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

--------------------------------------------------------------
>58225_58225_10_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000455934_RBM39_chr20_34301018_ENST00000361162_length(transcript)=1514nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGATTTGCAAACAAGACTTTCCCAGCAGAC
TGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACATGTTTAACCCTCAAACAGA
AGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTATTCATATTTATGTTGACAA
AAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATTGCATGGCAGGTGGTTTGC
TGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGCAACACAGCTACTGGTTCC
AAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAGTTATCTTTTATTTAGATA
AAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAACAGGAATGCAGTGTGCTC
ATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTAGAAAATTAATGAACTATA
GGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTCAGAAGCCTAACTTTTTAC
ACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACATTTAGTGTATGGAAATACA
AGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCAAAATTATATTTCTTGATG
GTATCTTTTCAATTAATGTATCTGTAAAAGTTTCTTTGTAAATACTATGTGTTCTGGTGTGTCTTAAAATTCCAAACAAAATGATCCCTG
CATTTCCTGAAGATGTTTAAACGTGAGAGTCTGGTAGGCAAAGCAGTCTGAGAAAGAAATAGGAAATGCAGAAATAGGTTTTGTCTGGTT
GCATATAATCTTTGCTCTTTTTAAGCTCTGTGAGCTCTGAAATATATTTTTGGGTTACTTCAGTGTGTTTGACAAGACAGCTTGATATTT

>58225_58225_10_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000455934_RBM39_chr20_34301018_ENST00000361162_length(amino acids)=193AA_BP=34
MRIRGSSGTLSRINMLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVADLQTRLSQQTEASALAAAASVQPLATQCFQ
LSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPD

--------------------------------------------------------------
>58225_58225_11_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000455934_RBM39_chr20_34301018_ENST00000407261_length(transcript)=814nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAAC
AAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACAT
GTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTAT
TCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATT
GCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGC
AACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAG
TTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAA

>58225_58225_11_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000455934_RBM39_chr20_34301018_ENST00000407261_length(amino acids)=199AA_BP=34
MRIRGSSGTLSRINMLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

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>58225_58225_12_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000455934_RBM39_chr20_34301018_ENST00000528062_length(transcript)=1244nt_BP=164nt
GAGAGCCGGCAGATGGGGGGCTTTTAGCCACGGTCTCTGGTCTGATGAAGCAGAAAAGAAGATGAGGATCAGGGGGTCCTCGGGAACGCT
GTCACGAATCAATATGTTAAGGATACCTGTAAGAAAGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGTGGTACAGGTTTGCAGAT
TCCGCCAGCAGCACAGCAAGCTCTACAGATGAGTGGCTCTTTGGCATTTGGTGCTGTGGCAGAATTCTCTTTTGTTATAGATTTGCAAAC
AAGACTTTCCCAGCAGACTGAAGCTTCAGCTTTAGCTGCAGCTGCCTCTGTTCAGCCACTTGCAACACAATGTTTCCAACTCTCTAACAT
GTTTAACCCTCAAACAGAAGAAGAAGTTGGATGGGATACCGAGATTAAGGATGATGTGATTGAAGAATGTAATAAACATGGAGGAGTTAT
TCATATTTATGTTGACAAAAATTCAGCTCAGGGCAATGTGTATGTGAAGTGCCCATCAATTGCTGCAGCTATTGCTGCTGTCAATGCATT
GCATGGCAGGTGGTTTGCTGGTAAAATGATAACAGCAGCATATGTACCTCTTCCAACTTACCACAACCTGTTTCCTGATTCTATGACAGC
AACACAGCTACTGGTTCCAAGTAGACGATGAAGGAAGATATAGTCCCTTATGTATATAGCTTTTTTTCTTTCTTGAGAATTCATCTTGAG
TTATCTTTTATTTAGATAAAAATAAAGAGGCAAGGATCTACTGTCATTTGTATGCAATTTCCTGTTACCTTGAAAAAATAAAAATGTTAA
CAGGAATGCAGTGTGCTCATTCTCCCTAAATAGTAAATCCCACTGTATACAAAACTGTTCTCTTGTTCTGCCTTTTAAAATGTTCATGTA
GAAAATTAATGAACTATAGGAATAGCTCTAGGAGAACAAATGTGCTTTCTGTAAAAAGGCAGACCAGGGATGTAATGTTTTTAATGTTTC
AGAAGCCTAACTTTTTACACAGTGGTTACATTTCACATTTCACTAATGTTGATATTTGGCTGATGGTTGAGCAGTTTCTGAAATACACAT
TTAGTGTATGGAAATACAAGACAGCTAAAGGGCTGTTTGGTTAGCATCTCATCTTGCATTCTGATCAATTGGCAAGAAAGGGAGATTTCA

>58225_58225_12_NDUFS1-RBM39_NDUFS1_chr2_207018341_ENST00000455934_RBM39_chr20_34301018_ENST00000528062_length(amino acids)=199AA_BP=34
MRIRGSSGTLSRINMLRIPVRKALVGLSKSPKGCGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPL
ATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTY

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Fusion Gene PPI Analysis for NDUFS1-RBM39


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneRBM39chr2:207018341chr20:34301018ENST00000528062916355_406343.3333333333333509.0ESR1 and ESR2
TgeneRBM39chr2:207018341chr20:34301018ENST000002533631017406_530365.3333333333333531.0NCOA6
TgeneRBM39chr2:207018341chr20:34301018ENST000003611621017406_530365.3333333333333525.0NCOA6
TgeneRBM39chr2:207018341chr20:34301018ENST00000528062916406_530343.3333333333333509.0NCOA6


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRBM39chr2:207018341chr20:34301018ENST000002533631017355_406365.3333333333333531.0ESR1 and ESR2
TgeneRBM39chr2:207018341chr20:34301018ENST000003611621017355_406365.3333333333333525.0ESR1 and ESR2
TgeneRBM39chr2:207018341chr20:34301018ENST000002533631017291_406365.3333333333333531.0JUN
TgeneRBM39chr2:207018341chr20:34301018ENST000003611621017291_406365.3333333333333525.0JUN
TgeneRBM39chr2:207018341chr20:34301018ENST00000528062916291_406343.3333333333333509.0JUN


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NDUFS1-RBM39


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NDUFS1-RBM39


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource