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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABTB2-TYR (FusionGDB2 ID:583)

Fusion Gene Summary for ABTB2-TYR

check button Fusion gene summary
Fusion gene informationFusion gene name: ABTB2-TYR
Fusion gene ID: 583
HgeneTgene
Gene symbol

ABTB2

TYR

Gene ID

25841

7299

Gene nameankyrin repeat and BTB domain containing 2tyrosinase
SynonymsABTB2A|BTBD22ATN|CMM8|OCA1|OCA1A|OCAIA|SHEP3
Cytomap

11p13

11q14.3

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat and BTB/POZ domain-containing protein 2ankyrin repeat and BTB (POZ) domain containing 2tyrosinaseLB24-ABSK29-ABmonophenol monooxygenaseoculocutaneous albinism IAtumor rejection antigen AB
Modification date2020031320200322
UniProtAcc.

TDP2

Ensembl transtripts involved in fusion geneENST00000298992, ENST00000435224, 
ENST00000530814, 		ENST00000526139, 
ENST00000263321, 
Fusion gene scores* DoF score13 X 10 X 3=3905 X 5 X 4=100
# samples 167
** MAII scorelog2(16/390*10)=-1.28540221886225
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/100*10)=-0.514573172829758
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABTB2 [Title/Abstract] AND TYR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABTB2(34378247)-TYR(89017940), # samples:1
ABTB2(34378247)-TYR(89028310), # samples:1
ABTB2(34378248)-TYR(89028311), # samples:1
ABTB2(34378248)-TYR(89017941), # samples:1
Anticipated loss of major functional domain due to fusion event.ABTB2-TYR seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ABTB2-TYR seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ABTB2-TYR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTYR

GO:0042438

melanin biosynthetic process

8126111


check buttonFusion gene breakpoints across ABTB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TYR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A2BK-01AABTB2chr11

34378248

-TYRchr11

89017941

+
ChimerDB4BRCATCGA-AC-A2BK-01AABTB2chr11

34378248

-TYRchr11

89028311

+
ChimerDB4BRCATCGA-AC-A2BKABTB2chr11

34378247

-TYRchr11

89017940

+
ChimerDB4BRCATCGA-AC-A2BKABTB2chr11

34378247

-TYRchr11

89028310

+


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Fusion Gene ORF analysis for ABTB2-TYR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000298992ENST00000526139ABTB2chr11

34378248

-TYRchr11

89017941

+
5CDS-intronENST00000298992ENST00000526139ABTB2chr11

34378248

-TYRchr11

89028311

+
5CDS-intronENST00000298992ENST00000526139ABTB2chr11

34378247

-TYRchr11

89017940

+
5CDS-intronENST00000298992ENST00000526139ABTB2chr11

34378247

-TYRchr11

89028310

+
5CDS-intronENST00000435224ENST00000526139ABTB2chr11

34378248

-TYRchr11

89017941

+
5CDS-intronENST00000435224ENST00000526139ABTB2chr11

34378248

-TYRchr11

89028311

+
5CDS-intronENST00000435224ENST00000526139ABTB2chr11

34378247

-TYRchr11

89017940

+
5CDS-intronENST00000435224ENST00000526139ABTB2chr11

34378247

-TYRchr11

89028310

+
Frame-shiftENST00000298992ENST00000263321ABTB2chr11

34378248

-TYRchr11

89017941

+
Frame-shiftENST00000298992ENST00000263321ABTB2chr11

34378247

-TYRchr11

89017940

+
Frame-shiftENST00000435224ENST00000263321ABTB2chr11

34378248

-TYRchr11

89017941

+
Frame-shiftENST00000435224ENST00000263321ABTB2chr11

34378247

-TYRchr11

89017940

+
In-frameENST00000298992ENST00000263321ABTB2chr11

34378248

-TYRchr11

89028311

+
In-frameENST00000298992ENST00000263321ABTB2chr11

34378247

-TYRchr11

89028310

+
In-frameENST00000435224ENST00000263321ABTB2chr11

34378248

-TYRchr11

89028311

+
In-frameENST00000435224ENST00000263321ABTB2chr11

34378247

-TYRchr11

89028310

+
intron-3CDSENST00000530814ENST00000263321ABTB2chr11

34378248

-TYRchr11

89017941

+
intron-3CDSENST00000530814ENST00000263321ABTB2chr11

34378248

-TYRchr11

89028311

+
intron-3CDSENST00000530814ENST00000263321ABTB2chr11

34378247

-TYRchr11

89017940

+
intron-3CDSENST00000530814ENST00000263321ABTB2chr11

34378247

-TYRchr11

89028310

+
intron-intronENST00000530814ENST00000526139ABTB2chr11

34378248

-TYRchr11

89017941

+
intron-intronENST00000530814ENST00000526139ABTB2chr11

34378248

-TYRchr11

89028311

+
intron-intronENST00000530814ENST00000526139ABTB2chr11

34378247

-TYRchr11

89017940

+
intron-intronENST00000530814ENST00000526139ABTB2chr11

34378247

-TYRchr11

89028310

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000298992ABTB2chr1134378247-ENST00000263321TYRchr1189028310+117255520778252
ENST00000435224ABTB2chr1134378247-ENST00000263321TYRchr1189028310+19251308591531490
ENST00000298992ABTB2chr1134378248-ENST00000263321TYRchr1189028311+117255520778252
ENST00000435224ABTB2chr1134378248-ENST00000263321TYRchr1189028311+19251308591531490

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000298992ENST00000263321ABTB2chr1134378247-TYRchr1189028310+0.006467570.9935324
ENST00000435224ENST00000263321ABTB2chr1134378247-TYRchr1189028310+0.0252549830.97474504
ENST00000298992ENST00000263321ABTB2chr1134378248-TYRchr1189028311+0.006467570.9935324
ENST00000435224ENST00000263321ABTB2chr1134378248-TYRchr1189028311+0.0252549830.97474504

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Fusion Genomic Features for ABTB2-TYR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ABTB2chr1134378247-TYRchr1189028310+0.0090914270.99090856
ABTB2chr1134378247-TYRchr1189028310+0.0090914270.99090856
ABTB2chr1134378247-TYRchr1189017940+4.27E-050.9999573
ABTB2chr1134378247-TYRchr1189017940+4.27E-050.9999573
ABTB2chr1134378247-TYRchr1189028310+0.0090914270.99090856
ABTB2chr1134378247-TYRchr1189028310+0.0090914270.99090856
ABTB2chr1134378247-TYRchr1189017940+4.27E-050.9999573
ABTB2chr1134378247-TYRchr1189017940+4.27E-050.9999573

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ABTB2-TYR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:34378247/chr11:89017940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.TYR

TDP2

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.362

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTYRchr11:34378247chr11:89028310ENST0000026332135498_529455530.0Topological domainCytoplasmic
TgeneTYRchr11:34378248chr11:89028311ENST0000026332135498_529455530.0Topological domainCytoplasmic
TgeneTYRchr11:34378247chr11:89028310ENST0000026332135477_497455530.0TransmembraneHelical
TgeneTYRchr11:34378248chr11:89028311ENST0000026332135477_497455530.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABTB2chr11:34378247chr11:89028310ENST00000298992-117845_914108840.0DomainBTB
HgeneABTB2chr11:34378247chr11:89028310ENST00000435224-117845_9142941026.0DomainBTB
HgeneABTB2chr11:34378248chr11:89028311ENST00000298992-117845_914108840.0DomainBTB
HgeneABTB2chr11:34378248chr11:89028311ENST00000435224-117845_9142941026.0DomainBTB
HgeneABTB2chr11:34378247chr11:89028310ENST00000298992-117521_550108840.0RepeatNote=ANK 1
HgeneABTB2chr11:34378247chr11:89028310ENST00000298992-117567_596108840.0RepeatNote=ANK 2
HgeneABTB2chr11:34378247chr11:89028310ENST00000298992-117606_635108840.0RepeatNote=ANK 3
HgeneABTB2chr11:34378247chr11:89028310ENST00000298992-117649_678108840.0RepeatNote=ANK 4
HgeneABTB2chr11:34378247chr11:89028310ENST00000435224-117521_5502941026.0RepeatNote=ANK 1
HgeneABTB2chr11:34378247chr11:89028310ENST00000435224-117567_5962941026.0RepeatNote=ANK 2
HgeneABTB2chr11:34378247chr11:89028310ENST00000435224-117606_6352941026.0RepeatNote=ANK 3
HgeneABTB2chr11:34378247chr11:89028310ENST00000435224-117649_6782941026.0RepeatNote=ANK 4
HgeneABTB2chr11:34378248chr11:89028311ENST00000298992-117521_550108840.0RepeatNote=ANK 1
HgeneABTB2chr11:34378248chr11:89028311ENST00000298992-117567_596108840.0RepeatNote=ANK 2
HgeneABTB2chr11:34378248chr11:89028311ENST00000298992-117606_635108840.0RepeatNote=ANK 3
HgeneABTB2chr11:34378248chr11:89028311ENST00000298992-117649_678108840.0RepeatNote=ANK 4
HgeneABTB2chr11:34378248chr11:89028311ENST00000435224-117521_5502941026.0RepeatNote=ANK 1
HgeneABTB2chr11:34378248chr11:89028311ENST00000435224-117567_5962941026.0RepeatNote=ANK 2
HgeneABTB2chr11:34378248chr11:89028311ENST00000435224-117606_6352941026.0RepeatNote=ANK 3
HgeneABTB2chr11:34378248chr11:89028311ENST00000435224-117649_6782941026.0RepeatNote=ANK 4
TgeneTYRchr11:34378247chr11:89028310ENST000002633213519_476455530.0Topological domainLumenal%2C melanosome
TgeneTYRchr11:34378248chr11:89028311ENST000002633213519_476455530.0Topological domainLumenal%2C melanosome


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Fusion Gene Sequence for ABTB2-TYR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>583_583_1_ABTB2-TYR_ABTB2_chr11_34378247_ENST00000298992_TYR_chr11_89028310_ENST00000263321_length(transcript)=1172nt_BP=555nt
AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG
CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC
TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC
GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT
CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG
GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG
GCAAGAACGCCAATGACCCAGACTCTTTTCAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGGG
CGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGTCGTCACAAGAGAAAGCAGCTTCCTGAAGAAA
AGCAGCCACTCCTCATGGAGAAAGAGGATTACCACAGCTTGTATCAGAGCCATTTATAAAAGGCTTAGGCAATAGAGTAGGGCCAAAAAG
CCTGACCTCACTCTAACTCAAAGTAATGTCCAGGTTCCCAGAGAATATCTGCTGGTATTTTTCTGTAAAGACCATTTGCAAAATTGTAAC
CTAATACAAAGTGTAGCCTTCTTCCAACTCAGGTAGAACACACCTGTCTTTGTCTTGCTGTTTTCACTCAGCCCTTTTAACATTTTCCCC
TAAGCCCATATGTCTAAGGAAAGGATGCTATTTGGTAATGAGGAACTGTTATTTGTATGTGAATTAAAGTGCTCTTATTTTAAAAAATTG
AAATAATTTTGATTTTTGCCTTCTGATTATTTAAAGATCTATATATGTTTTATTGGCCCCTTCTTTATTTTAATAAAACAGTGAGAAATC

>583_583_1_ABTB2-TYR_ABTB2_chr11_34378247_ENST00000298992_TYR_chr11_89028310_ENST00000263321_length(amino acids)=252AA_BP=178
MPQFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFS
VGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANDP

--------------------------------------------------------------
>583_583_2_ABTB2-TYR_ABTB2_chr11_34378247_ENST00000435224_TYR_chr11_89028310_ENST00000263321_length(transcript)=1925nt_BP=1308nt
AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC
CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA
GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG
GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT
TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC
TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT
CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG
ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT
GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG
CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC
AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG
CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA
TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA
GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG
GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGACCCAGACTCTTTTCAAGACTACATTAAGTCCTATTTGGAAC
AAGCGAGTCGGATCTGGTCATGGCTCCTTGGGGCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGT
GTCGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGATTACCACAGCTTGTATCAGAGCCATTTAT
AAAAGGCTTAGGCAATAGAGTAGGGCCAAAAAGCCTGACCTCACTCTAACTCAAAGTAATGTCCAGGTTCCCAGAGAATATCTGCTGGTA
TTTTTCTGTAAAGACCATTTGCAAAATTGTAACCTAATACAAAGTGTAGCCTTCTTCCAACTCAGGTAGAACACACCTGTCTTTGTCTTG
CTGTTTTCACTCAGCCCTTTTAACATTTTCCCCTAAGCCCATATGTCTAAGGAAAGGATGCTATTTGGTAATGAGGAACTGTTATTTGTA
TGTGAATTAAAGTGCTCTTATTTTAAAAAATTGAAATAATTTTGATTTTTGCCTTCTGATTATTTAAAGATCTATATATGTTTTATTGGC

>583_583_2_ABTB2-TYR_ABTB2_chr11_34378247_ENST00000435224_TYR_chr11_89028310_ENST00000263321_length(amino acids)=490AA_BP=416
MRRRLLLLPPPPCSPGIPSLWRTDSLLVGIRGGQGGVPGGSDGVLSSGSCESGRRERGAPAGHGSRPPSRGLRAGNAAAEPRDAERKEGG
PEGLELVSAHLGKRAWSCECPSLGDAALGRLPMAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYS
GSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSV
LHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENL
VEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLT

--------------------------------------------------------------
>583_583_3_ABTB2-TYR_ABTB2_chr11_34378248_ENST00000298992_TYR_chr11_89028311_ENST00000263321_length(transcript)=1172nt_BP=555nt
AAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGGCCGGGCTGCTCCGCAGGGCACTGATCCGCGTGG
CCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGCAGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGC
TGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCGCCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGC
GCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAATCTCCGTGCGCATCCACGAGTACGCAGCCATCT
CCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCAGCCACAGCCCTGATGGCGGAGGGGCCGGAGGCG
GGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGGGCGTCTTGCAGCCCTATGAGCATCTCATCTGCG
GCAAGAACGCCAATGACCCAGACTCTTTTCAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGGG
CGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGTCGTCACAAGAGAAAGCAGCTTCCTGAAGAAA
AGCAGCCACTCCTCATGGAGAAAGAGGATTACCACAGCTTGTATCAGAGCCATTTATAAAAGGCTTAGGCAATAGAGTAGGGCCAAAAAG
CCTGACCTCACTCTAACTCAAAGTAATGTCCAGGTTCCCAGAGAATATCTGCTGGTATTTTTCTGTAAAGACCATTTGCAAAATTGTAAC
CTAATACAAAGTGTAGCCTTCTTCCAACTCAGGTAGAACACACCTGTCTTTGTCTTGCTGTTTTCACTCAGCCCTTTTAACATTTTCCCC
TAAGCCCATATGTCTAAGGAAAGGATGCTATTTGGTAATGAGGAACTGTTATTTGTATGTGAATTAAAGTGCTCTTATTTTAAAAAATTG
AAATAATTTTGATTTTTGCCTTCTGATTATTTAAAGATCTATATATGTTTTATTGGCCCCTTCTTTATTTTAATAAAACAGTGAGAAATC

>583_583_3_ABTB2-TYR_ABTB2_chr11_34378248_ENST00000298992_TYR_chr11_89028311_ENST00000263321_length(amino acids)=252AA_BP=178
MPQFSAEAVRRLAGLLRRALIRVAREAQRLSVLHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFS
VGRFFRWMVDTRISVRIHEYAAISLTACMENLVEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANDP

--------------------------------------------------------------
>583_583_4_ABTB2-TYR_ABTB2_chr11_34378248_ENST00000435224_TYR_chr11_89028311_ENST00000263321_length(transcript)=1925nt_BP=1308nt
AGAAGTTTGCAGAGCGCTTTCTCGCCGGCTGGTCCCGGACTCGCGCTGCGCCCTGCGCCCTGCGCCGCCGCCTCCTCCTTCTGCCGCCGC
CGCCCTGTTCTCCCGGGATTCCTTCTCTGTGGAGGACTGACTCTCTGCTTGTGGGAATTAGAGGTGGACAAGGGGGAGTGCCGGGGGGTA
GCGACGGGGTTCTTTCCAGTGGCAGCTGCGAGTCGGGACGCCGGGAGCGTGGGGCTCCTGCTGGCCACGGATCTCGGCCACCTTCCCGCG
GCCTCCGGGCAGGCAATGCGGCCGCCGAGCCCCGCGACGCAGAGAGGAAGGAGGGTGGCCCGGAGGGCCTAGAGCTTGTTTCTGCCCACT
TGGGAAAGAGGGCATGGAGTTGTGAGTGCCCCTCGCTCGGCGACGCCGCCCTCGGCAGGCTCCCCATGGCCGGGACGTACAGCTCGACTC
TGAAGACGCTGGAGGACTTGACCTTGGACTCCGGGTATGGGGCCGGGGACTCGTGCCGCTCGCTCAGCCTCTCGTCCTCCAAGTCCAACT
CGCAGGCGCTCAACTCTTCGGCGCAGCAGCACCGCGGGGCGGCCTGGTGGTGCTACTCCGGCTCCATGAACAGCCGCCACAACAGCTGGG
ACACGGTGAACACGGTGCTGCCCGAGGACCCCGAAGTGGCCGACCTCTTCTCGCGCTGTCCGCGGCTCCCCGAGCTGGAGGAGTTCCCCT
GGACCGAAGGAGACGTGGCCCGGGTGCTCCGCAAAGGCGCTGGCGGCCGGCGGCTGCCCCAGTTCTCCGCCGAGGCGGTGAGGCGCCTGG
CCGGGCTGCTCCGCAGGGCACTGATCCGCGTGGCCCGCGAGGCGCAGCGCCTGAGCGTGCTGCACGCCAAGTGCACCCGCTTTGAGGTGC
AGAGCGCCGTGCGCCTGGTGCACAGCTGGGCGCTGGCCGAGAGCTGCGCGCTGGCAGCCGTCAAGGCGCTGTCCCTGTACAGCATGAGCG
CCGGCGACGGGCTGCGCCGGGGCAAGTCCGCGCGCTGCGGCCTCACCTTCTCAGTGGGTCGCTTTTTCCGCTGGATGGTGGACACCCGAA
TCTCCGTGCGCATCCACGAGTACGCAGCCATCTCCCTCACCGCCTGCATGGAGAACCTGGTGGAGGAGATCCGGGCCAGGGTGATGGCCA
GCCACAGCCCTGATGGCGGAGGGGCCGGAGGCGGGGAGGTGTCTGCTGAGGCCCTGGAGATGGTCATCAACAACGACGCCGAGCTCTGGG
GCGTCTTGCAGCCCTATGAGCATCTCATCTGCGGCAAGAACGCCAATGACCCAGACTCTTTTCAAGACTACATTAAGTCCTATTTGGAAC
AAGCGAGTCGGATCTGGTCATGGCTCCTTGGGGCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGT
GTCGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGATTACCACAGCTTGTATCAGAGCCATTTAT
AAAAGGCTTAGGCAATAGAGTAGGGCCAAAAAGCCTGACCTCACTCTAACTCAAAGTAATGTCCAGGTTCCCAGAGAATATCTGCTGGTA
TTTTTCTGTAAAGACCATTTGCAAAATTGTAACCTAATACAAAGTGTAGCCTTCTTCCAACTCAGGTAGAACACACCTGTCTTTGTCTTG
CTGTTTTCACTCAGCCCTTTTAACATTTTCCCCTAAGCCCATATGTCTAAGGAAAGGATGCTATTTGGTAATGAGGAACTGTTATTTGTA
TGTGAATTAAAGTGCTCTTATTTTAAAAAATTGAAATAATTTTGATTTTTGCCTTCTGATTATTTAAAGATCTATATATGTTTTATTGGC

>583_583_4_ABTB2-TYR_ABTB2_chr11_34378248_ENST00000435224_TYR_chr11_89028311_ENST00000263321_length(amino acids)=490AA_BP=416
MRRRLLLLPPPPCSPGIPSLWRTDSLLVGIRGGQGGVPGGSDGVLSSGSCESGRRERGAPAGHGSRPPSRGLRAGNAAAEPRDAERKEGG
PEGLELVSAHLGKRAWSCECPSLGDAALGRLPMAGTYSSTLKTLEDLTLDSGYGAGDSCRSLSLSSSKSNSQALNSSAQQHRGAAWWCYS
GSMNSRHNSWDTVNTVLPEDPEVADLFSRCPRLPELEEFPWTEGDVARVLRKGAGGRRLPQFSAEAVRRLAGLLRRALIRVAREAQRLSV
LHAKCTRFEVQSAVRLVHSWALAESCALAAVKALSLYSMSAGDGLRRGKSARCGLTFSVGRFFRWMVDTRISVRIHEYAAISLTACMENL
VEEIRARVMASHSPDGGGAGGGEVSAEALEMVINNDAELWGVLQPYEHLICGKNANDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLT

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Fusion Gene PPI Analysis for ABTB2-TYR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABTB2-TYR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABTB2-TYR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource