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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEBL-CAMK1D (FusionGDB2 ID:58341)

Fusion Gene Summary for NEBL-CAMK1D

check button Fusion gene summary
Fusion gene informationFusion gene name: NEBL-CAMK1D
Fusion gene ID: 58341
HgeneTgene
Gene symbol

NEBL

CAMK1D

Gene ID

10529

57118

Gene namenebulettecalcium/calmodulin dependent protein kinase ID
SynonymsC10orf113|LASP2|LNEBL|bA165O3.1CKLiK|CaM-K1|CaMKID
Cytomap

10p12.31

10p13

Type of geneprotein-codingprotein-coding
DescriptionnebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk proteincalcium/calmodulin-dependent protein kinase type 1DCAMK1D/ANAPC5 fusionCaM kinase IDCamKI-like protein kinasecaM kinase I deltacaM-KI deltacaMKI delta
Modification date2020031320200313
UniProtAcc

O76041

Q8IU85

Ensembl transtripts involved in fusion geneENST00000417816, ENST00000377119, 
ENST00000377122, ENST00000377159, 
ENST00000464278, 
ENST00000378845, 
ENST00000487696, ENST00000378847, 
Fusion gene scores* DoF score15 X 12 X 6=108016 X 18 X 6=1728
# samples 1619
** MAII scorelog2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/1728*10)=-3.18503189383252
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEBL [Title/Abstract] AND CAMK1D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEBL(21461312)-CAMK1D(12595224), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCAMK1D

GO:0032793

positive regulation of CREB transcription factor activity

16324104


check buttonFusion gene breakpoints across NEBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAMK1D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-XF-A8HD-01ANEBLchr10

21461312

-CAMK1Dchr10

12595224

+


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Fusion Gene ORF analysis for NEBL-CAMK1D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000417816ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
5CDS-intronENST00000417816ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
In-frameENST00000417816ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-3CDSENST00000377119ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-3CDSENST00000377122ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-3CDSENST00000377159ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-3CDSENST00000464278ENST00000378847NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377119ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377119ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377122ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377122ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377159ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000377159ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000464278ENST00000378845NEBLchr10

21461312

-CAMK1Dchr10

12595224

+
intron-intronENST00000464278ENST00000487696NEBLchr10

21461312

-CAMK1Dchr10

12595224

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000417816NEBLchr1021461312-ENST00000378847CAMK1Dchr1012595224+82435183541583409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000417816ENST00000378847NEBLchr1021461312-CAMK1Dchr1012595224+0.0015604780.9984395

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Fusion Genomic Features for NEBL-CAMK1D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NEBLchr1021461311-CAMK1Dchr1012595223+5.01E-070.9999995
NEBLchr1021461311-CAMK1Dchr1012595223+5.01E-070.9999995

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NEBL-CAMK1D


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:21461312/chr10:12595224)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEBL

O76041

CAMK1D

Q8IU85

FUNCTION: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028, ECO:0000269|PubMed:27733623}.FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. {ECO:0000269|PubMed:11050006, ECO:0000269|PubMed:15840691, ECO:0000269|PubMed:16324104, ECO:0000269|PubMed:17056143}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCAMK1Dchr10:21461312chr10:12595224ENST00000378845010326_36430358.0Compositional biasNote=Ser-rich
TgeneCAMK1Dchr10:21461312chr10:12595224ENST00000378847011326_36430386.0Compositional biasNote=Ser-rich
TgeneCAMK1Dchr10:21461312chr10:12595224ENST00000378845010318_32430358.0MotifNuclear export signal
TgeneCAMK1Dchr10:21461312chr10:12595224ENST00000378847011318_32430386.0MotifNuclear export signal
TgeneCAMK1Dchr10:21461312chr10:12595224ENST0000037884501029_3730358.0Nucleotide bindingATP
TgeneCAMK1Dchr10:21461312chr10:12595224ENST0000037884701129_3730386.0Nucleotide bindingATP
TgeneCAMK1Dchr10:21461312chr10:12595224ENST00000378845010279_31930358.0RegionAutoinhibitory domain
TgeneCAMK1Dchr10:21461312chr10:12595224ENST00000378845010299_32030358.0RegionCalmodulin-binding
TgeneCAMK1Dchr10:21461312chr10:12595224ENST00000378847011279_31930386.0RegionAutoinhibitory domain
TgeneCAMK1Dchr10:21461312chr10:12595224ENST00000378847011299_32030386.0RegionCalmodulin-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128954_101401015.0DomainSH3
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27954_101454271.0DomainSH3
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128836_95301015.0RegionNote=Linker
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27836_95354271.0RegionNote=Linker
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128100_13601015.0RepeatNote=Nebulin 3
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128137_17201015.0RepeatNote=Nebulin 4
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128173_20501015.0RepeatNote=Nebulin 5
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128206_24101015.0RepeatNote=Nebulin 6
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128242_27801015.0RepeatNote=Nebulin 7
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128279_31301015.0RepeatNote=Nebulin 8
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-12829_6301015.0RepeatNote=Nebulin 1
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128314_34801015.0RepeatNote=Nebulin 9
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128349_38501015.0RepeatNote=Nebulin 10
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128386_42201015.0RepeatNote=Nebulin 11
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128423_45901015.0RepeatNote=Nebulin 12
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128460_49601015.0RepeatNote=Nebulin 13
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128497_53301015.0RepeatNote=Nebulin 14
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128534_56901015.0RepeatNote=Nebulin 15
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128570_59901015.0RepeatNote=Nebulin 16
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128600_63501015.0RepeatNote=Nebulin 17
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128636_66601015.0RepeatNote=Nebulin 18
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-12864_9901015.0RepeatNote=Nebulin 2
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128667_69301015.0RepeatNote=Nebulin 19
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128694_72801015.0RepeatNote=Nebulin 20
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128729_75901015.0RepeatNote=Nebulin 21
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128760_79401015.0RepeatNote=Nebulin 22
HgeneNEBLchr10:21461312chr10:12595224ENST00000377122-128795_83001015.0RepeatNote=Nebulin 23
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27100_13654271.0RepeatNote=Nebulin 3
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27137_17254271.0RepeatNote=Nebulin 4
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27173_20554271.0RepeatNote=Nebulin 5
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27206_24154271.0RepeatNote=Nebulin 6
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27242_27854271.0RepeatNote=Nebulin 7
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27279_31354271.0RepeatNote=Nebulin 8
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-2729_6354271.0RepeatNote=Nebulin 1
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27314_34854271.0RepeatNote=Nebulin 9
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27349_38554271.0RepeatNote=Nebulin 10
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27386_42254271.0RepeatNote=Nebulin 11
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27423_45954271.0RepeatNote=Nebulin 12
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27460_49654271.0RepeatNote=Nebulin 13
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27497_53354271.0RepeatNote=Nebulin 14
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27534_56954271.0RepeatNote=Nebulin 15
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27570_59954271.0RepeatNote=Nebulin 16
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27600_63554271.0RepeatNote=Nebulin 17
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27636_66654271.0RepeatNote=Nebulin 18
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-2764_9954271.0RepeatNote=Nebulin 2
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27667_69354271.0RepeatNote=Nebulin 19
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27694_72854271.0RepeatNote=Nebulin 20
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27729_75954271.0RepeatNote=Nebulin 21
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27760_79454271.0RepeatNote=Nebulin 22
HgeneNEBLchr10:21461312chr10:12595224ENST00000417816-27795_83054271.0RepeatNote=Nebulin 23
TgeneCAMK1Dchr10:21461312chr10:12595224ENST0000037884501023_27930358.0DomainProtein kinase
TgeneCAMK1Dchr10:21461312chr10:12595224ENST0000037884701123_27930386.0DomainProtein kinase


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Fusion Gene Sequence for NEBL-CAMK1D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58341_58341_1_NEBL-CAMK1D_NEBL_chr10_21461312_ENST00000417816_CAMK1D_chr10_12595224_ENST00000378847_length(transcript)=8243nt_BP=518nt
CCTGCGCGGCGGCGGCGGCGAGGCGGGGGAGCGAGTGAGCGCGAGGGGCGGGCGCGAGTGACTGTGTGAGTCACCCGTACCTGGAGTGCG
AGCGACGCAGAGCCAGCGGCGCGGAGCCGGAGCCGGAGCCGAGACCCAGCGCCTGCGAGCCCGAGAGCGCGGCCGGCCCCAGGCGCCAGG
CCCCGTCGCCCTCCCCGTGCACTCACCCGTGGCCCGGCGCCGACTCCCTACCCGGCGCCCGCCGCCCGCAGCCCTCCCGCCTGCCAGGAG
GCGGTGCGGGGCTCGCCGGGGGATGTCACAGCGGCTCCTGGGAGCCAGCAGCCGCCGCCGCCGCCGCCCCCGGGAACCGCGATCATGAAC
CCCCAGTGCGCCCGTTGCGGAAAAGTCGTGTATCCCACCGAGAAAGTCAACTGCCTGGATAAGTATTGGCATAAAGGATGTTTCCATTGT
GAGGTCTGCAAGATGGCACTCAACATGAACAACTACAAAGGCTATGAAAAGAAGCCCTATTGTAATGCCGGGGCCTTTTCCGAAGTGGTT
TTAGCTGAAGAGAAGGCAACTGGCAAGCTCTTTGCTGTGAAGTGTATCCCTAAGAAGGCGCTGAAGGGCAAGGAAAGCAGCATAGAGAAT
GAGATAGCCGTCCTGAGAAAGATTAAGCATGAAAATATTGTTGCCCTGGAAGACATTTATGAAAGCCCAAATCACCTGTACTTGGTCATG
CAGCTGGTGTCCGGTGGAGAGCTGTTTGACCGGATAGTGGAGAAGGGGTTTTATACAGAGAAGGATGCCAGCACTCTGATCCGCCAAGTC
TTGGACGCCGTGTACTATCTCCACAGAATGGGCATCGTCCACAGAGACCTCAAGCCCGAAAATCTCTTGTACTACAGTCAAGATGAGGAG
TCCAAAATAATGATCAGTGACTTTGGATTGTCAAAAATGGAGGGCAAAGGAGATGTGATGTCCACTGCCTGTGGAACTCCAGGCTATGTC
GCTCCTGAAGTCCTCGCCCAGAAACCTTACAGCAAAGCCGTTGACTGCTGGTCCATCGGAGTGATTGCCTACATCTTGCTCTGCGGCTAC
CCTCCTTTTTATGATGAAAATGACTCCAAGCTCTTTGAGCAGATCCTCAAGGCGGAATATGAGTTTGACTCTCCCTACTGGGATGACATC
TCCGACTCTGCAAAAGACTTCATTCGGAACCTGATGGAGAAGGACCCGAATAAAAGATACACGTGTGAGCAGGCAGCTCGGCACCCATGG
ATCGCTGGTGACACAGCCCTCAACAAAAACATCCACGAGTCCGTCAGCGCCCAGATCCGGAAAAACTTTGCCAAGAGCAAATGGAGACAA
GCATTTAATGCCACGGCCGTCGTCAGACATATGAGAAAACTACACCTCGGCAGCAGCCTGGACAGTTCAAATGCAAGTGTTTCGAGCAGC
CTCAGTTTGGCCAGCCAAAAAGACTGTCTGGCACCTTCCACGCTCTGTAGTTTCATTTCTTCTTCGTCGGGGGTCTCAGGAGTTGGAGCC
GAGCGGAGACCCAGGCCCACCACTGTGACGGCAGTGCACTCTGGAAGCAAGTGACTGGCCCTGGAGGTGGGGCCCGGGGTCGGGGCTGGG
GAAGGGGAGCCCCAGGGTCGCCAGAGCCGCGAGCCACTCCAGCGAGACCCCACCTTGCATGGTGCCCCTTCCTGCATAGGACTGGAAGAC
CGAAGTTTTTTTATGGCCATATTTTCTACTGCAATTCTGAAGTGTTCATTTCTCACAAACTGTACTGACTCGAGGGGCGCTGATTTCATA
GGATCTGGTGCTGTATATACGAATCTTGCAAAGCTCTAACTGAACGGACCTTCTTATTCCTCTCCCCTAACACCATCGTTTCCACTCTTC
TCAGTGTAGGTAACCGTCTATGGTGTGTTTTTTCATTAATGACAAAAAAAAAAAGGTTTCAACTGGATTATTTAAATATTGGTAAATATT
GTGCATTAGGGTTTGTTTTTCCTTTTAAGAAGTATGTCCTTTGTATCTCTAAGTTACATGACCTATATCTTTTCCTCTTTAATAGTAGTT
TTATGTTAACCTTTAAGAGATTTGTTTTTCCTCAAAGGAGAATTTAAAGGTATTTTTTAAAATTCTAATAAGAGGATCAGCCGGGTGCAA
TGACTCATGCCTGTAATCCCAGCACGTTGGGAGGCCAAGTCGGGCGGATCACAAGGTCAGGAGATCAAGGCCATCCTGGCCAACATGGTG
AAACCCCACGTCTACTAAAAATACAAAAAATTAGCCGGGCGTGGTGGCACACACCTGTAGTCCCGGCTACTCGGGAGGCTGAGGCAGGAG
AATTGCTTGAACCCGGGAGACGGAGGTTGCAGTGAGCTGAGATCGTGCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCTGTCTCA
AAAAAAAAAAAAAAAATTCTAACAAGAGGATCATGAATCTGTCTCCAAGGCTAAGAGTGCCCTTCACCTCTACTCCTTCTGTTTCTCTCC
CCTTCCCCAGGAGGAGGGGCCCCTCAGTTCTGCGAGGCTCTCTTCTCTGCGGGGGACTTTGGTAGAGAATCTGCACAGAGCCTTTGCTGG
CAACCCATCCAGCAGAACCCACACCCACCAGAGACCCTAGAGGCCTCTTGCCATCAGCAACCAGAAATAAGCCTGCTCCCCCGAGACGCA
GGGCTCAGCTTCACAGGCCAGACTTGCTGTGAGTGAGATGCCCACACTGCAGAGATGCAGGACCCTCCCTTGCAAAAGGAACCAGCTGCC
ATGTTGCTGAAAGTGGGCCCACACACAACCCTCATTTCTCACGAGAGCTAACAGATGAAAGCTCAGCTATGCAGTGTTAAAATTCATCTC
TTTCTCTGTGGTTTTTAAAAAAATGCATTTCTAATCTTACACTTCACGTGGCCTCCAACACAAAGTTCTTTCTCCACATTTTTACCCTCT
TCTCACATGAATGTTTTCCAAGGGAAGGAAGGGAGGGAAGCAGCCTTGGGAAAGGATCCATTTCTGGTGGTAAGGAGAGGGGGCCCTGCC
AGGCTAATGGGACTTCAGCCACCACAGAGATGACCAAAGACCACCTCCGCCAGGCCCAGCCAGTGCTTGCAGCCCTCCCATTGGTCAGGG
GAGTCTAAAATCAAAGATACATGGTGGTAGGGTCACCAAACGTCCCATTTGCCCGAGACTGAAGGATTTCTCAGGCTGTGGACATTTAAT
GCCAAAACCAGGAATATCCGGGGCAAAGCAGGCTGTGTTGTTCGCCTTTGTGGAGCCAGGCAGTGTGTGGCCCAGGGAAAGCTGCGTTTC
ATGGAGGCTTCCAGGAGGCTGCCCTGTAAAGCCAGGCAGGTGGCTTCAAGTGCCATTCCTGCAAGTGCCCCTGCTTCAGCTCTCAGGCCC
ATCCAATGCCTCGAGCCCACGGGGGTGTCCCGGCAGGTCTGCGTCATCACGACCCAGTAACGCTGCTGGCTGTGTCCTCATGCCCTCTTC
CTCTGGCTGGCCAGTCATGGGAAGTCCTGTTGGTTGAGTCATCTTTGTCACTTCTACACCTTTGAGTATGTACAGGCTGAATGTTGAGTG
ATGCCCCCCCACCCTCTCAATAAACACACACACACACACACACACACACACACACACACACAATGTTATTAGGCACAGCAGCTCCATCCT
GCTCCCTGAGAATGGCAGTGCAGGCACAGAGAAGAGCAGTTGGGAAGACAGGCAGCTGGTCTACCCTGTCCCCGCACACTTCACAGGCAC
TCCACTGCTTGGCAGGAATTCTGCATGGCATCTGCCACGCATGCTCACAGGGTGAAAAATCAAGCTGTCACTCTGCAAAATCTAAAAACC
CTGGAAAGGTCTATAAGATGACATTAGACCCAGTTAAGAAGCAAGTGTCACCTGAGTTGGCCATGCAATGAATGAATATTATAAGCAGTA
TTGGAGAACTAGGCGGTTGCTTACTAAGAAGTGTCTTGGAAACATTCGAGTTCATACAGTGCATGACAAAGTAATAGAAGGCTGCAAGCG
CTGAAAATGCACCCGAATCTGGTACCTAGGATGAGTACATGAATAGTGATGAATAGCCCTTTGTGCTGTGTGCTATATACAACCATTTGC
ATTCAGAAAGCAGCATTTGAAGCTGAGTTCCATTACTGGTGATTGAAGTATTTTCAGGAGCAGATACATGTGGTGCATGTTATATGCACT
TAGTTTGAAAGTATCCCTCACCCAAAAAGTGCAGAACCTCTGAAAGGTGAGCCGTGGTGCAGGTGCCCCCCTCGCTGTTCGGGTCAGTTC
TTGGCCATGCTTGGCCTGTCACACGCCGGGTCTCAACAACATCGTGCGAGGAGACAGTGACTGGTTTCAGCCCAAGAGTCAACTGTTGAG
CATGACATCAGGAAGCCTGTACTGTCCTGATCCCACCAGGCTTGGGTTAATTTCCTATTGCTTCAGAGAAAGAGAGGCGCTCTTGTGCTT
TTGAGAGAGCTCTCATGTTAAAAAGAGGTTGTCTTTGCACTGCGCTTGGTATGATTTGTTTTCTTATAAAACAGGAAGAGAACCTAGAAT
GTGCCTTTCGTGAAGGTCTGACAAATGGGGTCTCAGAGTCCTAGGACCCGCACCAAGGTCAGAGTCCACCTGTAGAGGCTGAGCATTTCT
ACATGCACCCAGGGTGCTGGGCTGAGGCTAAGGGTGGACGCGTAGACCCCATCACAGGCTTCCTTCCTGAGCCCAAGTCCCCCATTTGGT
CACTATCCCTTCTCAGAGCAAGTGGATTCTCTTTTCCTCACTTGGAGTATTCAATGTTGAAGTAGTGGCCTGGAGTGGCCTTTCCCTCAG
CTGCCTGTCTGGGCCTCCCTGGCTTCCCGGATCTTCATCTCATACGTGAGGCAATAGGAGGAGTTTCTATTCATTGAGACAAACAGTGAG
CGGGCACCAACAGGCCAGCAGCTTGGCCCTTTTCACAGAGGTGGCCTTGGAGTCTGGAGTCTGGGCAGCTGTCTGCCTCTCTACGGCTCT
GCTTCCCAGCGGGCACACGGGTCCGGAGCCTCAGAATGAAGTGGTGCAGAGGCGCAGGGCACACCTAGGAGAAGCTCAATGACCACCAAA
GCCCTTGAGGAGAGACGGGGTTTGCTGTGTTAGAGAAATGGCAACCCCCAGGACCATGCACGGCTCTGGCAGTGCACAGTGGCTGATTTT
CACCAGTTCCTCCTACCCCTGCCTCTGTCGGAGACTAGAAAACATTCTACCCCTTCAGGTCTTCTTTTAAAAGAAAAGAGCTATGGCAAA
GCGTGCCATACAAAGTTAAAAAAAGGAAGAGTGGCTTTGCGTTCTTGACCATGGCCACAATTCTGGTCACTTCTAGCATCTGACCTTGAG
AACGGTGTAGAGTCTCTGAGCCACCGCTGGCCTTTGAGAGAGTCTCACTCTCCAGCTAGCTCTTTGTGTAGTGTCCAGGGCCCCGGCAGT
CAGGATAGAGCGAGCAAAAGAAGATGGACAGTGGACAGGGCGCAGTGGCTCACGCCTGTAATCCCAGCGCTTTGGGAGAGCGAGGCGGGC
AGATCACAAGGTCAAGAGATCAAGACCATTCTGGCCAACATGGTGAAACCCTGTTTCTACTAAAAATACAAAAATTAGCTGGGCATGGTG
GTGCGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATCGT
GCCACTGCACTCCAGCCTGGGTGACAGAGCAAGACTCCGTCTCAAAAAAGATGGCCATGCTGGCCAAGGCTGGGCTCATAGGAAATATCT
GTAGTAGGATGAAAGGAATCTGGCCTAGGGAGCCCCGGACTCGGTTTACCTACCCCGTACTCATCCCACTCATCTGTCTACCCTAGTGTC
CATCATGCCCTGGATGAATCGTAGGTGGGAGGGACAGAAGCCGAGAACACCAGGCACACGGGGTGGGGGGAATGGGGGGAGCCCAGGTGA
TCCCCTTTGGAAAGTGGATTGATCCTCTCCCCTGTGGAATGACAGCTTAACCTGATTAACCCACTGGGGCTTGCTATTTTATGAGCATTT
TTAAACAGAAAGGAAAGATGATATCCCAGTGCAGGTAGACTTTATTTTTGAAAGCATCGTGGCCCCTCACCTCTCCCTCTCCCCCAGAAC
CTTGGCCAGAATTGAGTCTTCGCGTTGGGGAGGCCACGCTGGAACCATTGCTCTAGGGCTGAAGGTGGAAGTAGGGCCACTGCCGCAGCT
TCAGCCAGAGCCCTCGCTGCTTCGCAGAATTTAACAAGCACACGACTGGGATTCCTTTGGATATGAGAAAGGAAGGCAAGTGCGGGCAAA
GGGAAGCTCCTCCCGTTTTTCATAAACAGAAGTAAGATGTCCTCTTTCCCAGGTTTGCACAATCACTTCTGGCAAATTAATTGAAGGTCC
TTGAATTCAGCCAGTGCACGAAACCTTTGCATGTTCTTCTGAAACTGTACTTCTTCCCTATTCTGTCTACCCACACTCTGCGAACTTTGC
CTTTTCCTTAAACACATTCCAGACCAAACACTGTTCAGTTTGTTAAAAAAAAAAAAAAAAAAAAAAGATGTATATACCTGTATGTGATCC
ACCACCCTTTTGAGGGGCACCTGGTCCTCGGTTGGGGCTGCAGGTGTGCCTGACATTTGCAAAAGATATTCCAGTCTTTCGATGTTCAGA
ATTGAAAATGTGGAGATAGAAAAGCTCAAACAGACTCCTAAAAGGAGGGTTTCTTTCCTGAAGACTCCAAGAAAATGAGTGTGCAGATGA
GTTAGCTTGACAACCTCAACTCTGGGGAGCAGGCAGGCGGTCTGAGGAAGATAAGGGCCCACGCCCCACTCACCTGGCACCTGTTCGGTG
GTCCCGGGGCATCATGGTCTGCAGCTCTGGGCCCCCAGCCCCACTGTGAAGTCAGTCCTGCATGCTGGCCGAGGCCCGGCCACCTCCCGA
TGCCTCCAGAGTCAGTGGGAAGGAGTCAGCCCTTCCCAGACTTCCCCGCCACCTCCAGCAGGAGCAGCTCAGTTTGTGGCTCTGGGAGCT
CCGCTTTTGCAAACCCAAAAAGGCTGTGCATTTGGAAGCCAAACGCTCAGCATGCGGCTGCCGAGTCTGGTTTTGTGGACAAAGCAAACT
GTGGAATGGCTTCTCGGTGTCTGTATAAAGGGACAAACGGTTGCATTCACCCTTTGTACTATAACACCGCTTCTGCATTCGCCATATCCG
TTTTTTAACCTTTTTGTCTCCGGGGAACTTCTCATTCGATTATTATGTCTTCTGATGATTTGCCATGTTATTTTAAAGGTGATTTTATTT
TCTTATGGACAGGAAAAAAGAAAATGAGGAGGAGTTGGTTTTACTCTTAGAGATAAGACTTCAGCAGGGGCTCAGAAACCCCAAACTCTA
GTTAAATTGCTTCTCGGAGGAAAATCTTAATCTAGACAGATTCAGATTCCCAGGCTCTCCTGGAAGCCCTGCACTTCAGGGCACAGGGGC
CCTGGGACGTGGTTGGCAGCCAGGCTGCGAGAGAGCTAAAAAGGAACAAGAACATCAGCTCGGATGTTTGTCTCTCAGCCCTGACACCTG
CCACTCTCCTTCCCGGGGCACTTGGCCCTATCAGAGGGACATGAAATGCTGTCCGAATGGTGGCAGAAATGCAGCGACATTGCATGCAGC
AGAGTCTTTGCTTCGAAAGATGGGGCGCCATGTTTCAGAGAACATTTATCTTAGTCCCACGTTCAGGTGAGAAGACCTCAAAGGTACCCT
CTGTCCAGAATAAACATTGGAACAATCTCTCAATTGGCTTTTGTCACTACACATAATGTAATCTCCCTTCTTTCAGCTCCCCCAACAGTG
AGCATGCTTCCCAAAAAATTACAACATCAAAACCAGGAATGTCCCCGCATCTACTATTACCAGGCTTGCAATTGGTTCAATTTTCCCATA
AAAACATGTTTGTCCAAAAGAAGGGAAACTGTGAATTTATTCCATGCATGTAATAAACTCTGCAAGAAGTTTAACCCACATAGGTTTGCG
GCACTGCAAAATTGTTCATGGGTCTATGTAGCAAATGATTCTCTGCCTTGACAATCATGTATACATATCAAGATTTCTATCATAATGATA

>58341_58341_1_NEBL-CAMK1D_NEBL_chr10_21461312_ENST00000417816_CAMK1D_chr10_12595224_ENST00000378847_length(amino acids)=409AA_BP=55
MNPQCARCGKVVYPTEKVNCLDKYWHKGCFHCEVCKMALNMNNYKGYEKKPYCNAGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSI
ENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQD
EESKIMISDFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQILKAEYEFDSPYWD
DISDSAKDFIRNLMEKDPNKRYTCEQAARHPWIAGDTALNKNIHESVSAQIRKNFAKSKWRQAFNATAVVRHMRKLHLGSSLDSSNASVS

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Fusion Gene PPI Analysis for NEBL-CAMK1D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEBL-CAMK1D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEBL-CAMK1D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource