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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEBL-DNAJC1 (FusionGDB2 ID:58342)

Fusion Gene Summary for NEBL-DNAJC1

check button Fusion gene summary
Fusion gene informationFusion gene name: NEBL-DNAJC1
Fusion gene ID: 58342
HgeneTgene
Gene symbol

NEBL

DNAJC1

Gene ID

10529

64215

Gene namenebuletteDnaJ heat shock protein family (Hsp40) member C1
SynonymsC10orf113|LASP2|LNEBL|bA165O3.1DNAJL1|ERdj1|HTJ1|MTJ1
Cytomap

10p12.31

10p12.31

Type of geneprotein-codingprotein-coding
DescriptionnebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk proteindnaJ homolog subfamily C member 1DnaJ (Hsp40) homolog, subfamily C, member 1DnaJ-like proteindnaJ protein homolog MTJ1
Modification date2020031320200313
UniProtAcc

O76041

Q96DA6

Ensembl transtripts involved in fusion geneENST00000377119, ENST00000377122, 
ENST00000377159, ENST00000417816, 
ENST00000464278, 		ENST00000483085, 
ENST00000376946, ENST00000376980, 
Fusion gene scores* DoF score15 X 12 X 6=108012 X 9 X 6=648
# samples 1613
** MAII scorelog2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEBL [Title/Abstract] AND DNAJC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEBL(21177026)-DNAJC1(22055238), # samples:3
DNAJC1(22171211)-NEBL(21076237), # samples:1
DNAJC1(21748380)-NEBL(21362855), # samples:1
Anticipated loss of major functional domain due to fusion event.DNAJC1-NEBL seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNAJC1

GO:0050708

regulation of protein secretion

14668352


check buttonFusion gene breakpoints across NEBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNAJC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AR-A1AH-01ANEBLchr10

21177026

-DNAJC1chr10

22055238

-
ChimerDB4BRCATCGA-D8-A1XU-01ANEBLchr10

21250601

-DNAJC1chr10

22095028

-


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Fusion Gene ORF analysis for NEBL-DNAJC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000377119ENST00000483085NEBLchr10

21177026

-DNAJC1chr10

22055238

-
5CDS-5UTRENST00000377122ENST00000483085NEBLchr10

21177026

-DNAJC1chr10

22055238

-
5CDS-5UTRENST00000377159ENST00000483085NEBLchr10

21250601

-DNAJC1chr10

22095028

-
5CDS-5UTRENST00000417816ENST00000483085NEBLchr10

21250601

-DNAJC1chr10

22095028

-
5CDS-intronENST00000377119ENST00000376946NEBLchr10

21177026

-DNAJC1chr10

22055238

-
5CDS-intronENST00000377122ENST00000376946NEBLchr10

21177026

-DNAJC1chr10

22055238

-
5CDS-intronENST00000377159ENST00000376946NEBLchr10

21250601

-DNAJC1chr10

22095028

-
5CDS-intronENST00000417816ENST00000376946NEBLchr10

21250601

-DNAJC1chr10

22095028

-
In-frameENST00000377119ENST00000376980NEBLchr10

21177026

-DNAJC1chr10

22055238

-
In-frameENST00000377122ENST00000376980NEBLchr10

21177026

-DNAJC1chr10

22055238

-
In-frameENST00000377159ENST00000376980NEBLchr10

21250601

-DNAJC1chr10

22095028

-
In-frameENST00000417816ENST00000376980NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-3CDSENST00000377119ENST00000376980NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-3CDSENST00000377122ENST00000376980NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-3CDSENST00000377159ENST00000376980NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-3CDSENST00000417816ENST00000376980NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-3CDSENST00000464278ENST00000376980NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-3CDSENST00000464278ENST00000376980NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-5UTRENST00000377119ENST00000483085NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-5UTRENST00000377122ENST00000483085NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-5UTRENST00000377159ENST00000483085NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-5UTRENST00000417816ENST00000483085NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-5UTRENST00000464278ENST00000483085NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-5UTRENST00000464278ENST00000483085NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-intronENST00000377119ENST00000376946NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-intronENST00000377122ENST00000376946NEBLchr10

21250601

-DNAJC1chr10

22095028

-
intron-intronENST00000377159ENST00000376946NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-intronENST00000417816ENST00000376946NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-intronENST00000464278ENST00000376946NEBLchr10

21177026

-DNAJC1chr10

22055238

-
intron-intronENST00000464278ENST00000376946NEBLchr10

21250601

-DNAJC1chr10

22095028

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377122NEBLchr1021177026-ENST00000376980DNAJC1chr1022055238-14837663971332311
ENST00000377119NEBLchr1021177026-ENST00000376980DNAJC1chr1022055238-109637910945311
ENST00000417816NEBLchr1021250601-ENST00000376980DNAJC1chr1022095028-15487113541397347
ENST00000377159NEBLchr1021250601-ENST00000376980DNAJC1chr1022095028-10942572943313

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377122ENST00000376980NEBLchr1021177026-DNAJC1chr1022055238-0.0013087440.99869126
ENST00000377119ENST00000376980NEBLchr1021177026-DNAJC1chr1022055238-0.0016257260.9983742
ENST00000417816ENST00000376980NEBLchr1021250601-DNAJC1chr1022095028-0.0081778520.9918222
ENST00000377159ENST00000376980NEBLchr1021250601-DNAJC1chr1022095028-0.0103971870.98960286

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Fusion Genomic Features for NEBL-DNAJC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEBL-DNAJC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:21177026/chr10:22055238)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEBL

O76041

DNAJC1

Q96DA6

FUNCTION: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028, ECO:0000269|PubMed:27733623}.FUNCTION: Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling (By similarity). May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity (By similarity). {ECO:0000250|UniProtKB:Q07914, ECO:0000250|UniProtKB:Q9CQV7}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-42829_631231015.0RepeatNote=Nebulin 1
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-42864_991231015.0RepeatNote=Nebulin 2
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-4729_63119271.0RepeatNote=Nebulin 1
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-4764_99119271.0RepeatNote=Nebulin 2
TgeneDNAJC1chr10:21177026chr10:22055238ENST00000376980812492_547366555.0DomainSANT 2
TgeneDNAJC1chr10:21250601chr10:22095028ENST00000376980712325_379326555.0DomainSANT 1
TgeneDNAJC1chr10:21250601chr10:22095028ENST00000376980712492_547326555.0DomainSANT 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428954_10141231015.0DomainSH3
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17954_10140271.0DomainSH3
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128954_101401015.0DomainSH3
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47954_1014119271.0DomainSH3
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428836_9531231015.0RegionNote=Linker
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17836_9530271.0RegionNote=Linker
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128836_95301015.0RegionNote=Linker
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47836_953119271.0RegionNote=Linker
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428100_1361231015.0RepeatNote=Nebulin 3
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428137_1721231015.0RepeatNote=Nebulin 4
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428173_2051231015.0RepeatNote=Nebulin 5
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428206_2411231015.0RepeatNote=Nebulin 6
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428242_2781231015.0RepeatNote=Nebulin 7
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428279_3131231015.0RepeatNote=Nebulin 8
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428314_3481231015.0RepeatNote=Nebulin 9
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428349_3851231015.0RepeatNote=Nebulin 10
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428386_4221231015.0RepeatNote=Nebulin 11
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428423_4591231015.0RepeatNote=Nebulin 12
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428460_4961231015.0RepeatNote=Nebulin 13
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428497_5331231015.0RepeatNote=Nebulin 14
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428534_5691231015.0RepeatNote=Nebulin 15
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428570_5991231015.0RepeatNote=Nebulin 16
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428600_6351231015.0RepeatNote=Nebulin 17
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428636_6661231015.0RepeatNote=Nebulin 18
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428667_6931231015.0RepeatNote=Nebulin 19
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428694_7281231015.0RepeatNote=Nebulin 20
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428729_7591231015.0RepeatNote=Nebulin 21
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428760_7941231015.0RepeatNote=Nebulin 22
HgeneNEBLchr10:21177026chr10:22055238ENST00000377122-428795_8301231015.0RepeatNote=Nebulin 23
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17100_1360271.0RepeatNote=Nebulin 3
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17137_1720271.0RepeatNote=Nebulin 4
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17173_2050271.0RepeatNote=Nebulin 5
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17206_2410271.0RepeatNote=Nebulin 6
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17242_2780271.0RepeatNote=Nebulin 7
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17279_3130271.0RepeatNote=Nebulin 8
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-1729_630271.0RepeatNote=Nebulin 1
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17314_3480271.0RepeatNote=Nebulin 9
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17349_3850271.0RepeatNote=Nebulin 10
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17386_4220271.0RepeatNote=Nebulin 11
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17423_4590271.0RepeatNote=Nebulin 12
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17460_4960271.0RepeatNote=Nebulin 13
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17497_5330271.0RepeatNote=Nebulin 14
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17534_5690271.0RepeatNote=Nebulin 15
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17570_5990271.0RepeatNote=Nebulin 16
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17600_6350271.0RepeatNote=Nebulin 17
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17636_6660271.0RepeatNote=Nebulin 18
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-1764_990271.0RepeatNote=Nebulin 2
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17667_6930271.0RepeatNote=Nebulin 19
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17694_7280271.0RepeatNote=Nebulin 20
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17729_7590271.0RepeatNote=Nebulin 21
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17760_7940271.0RepeatNote=Nebulin 22
HgeneNEBLchr10:21177026chr10:22055238ENST00000417816-17795_8300271.0RepeatNote=Nebulin 23
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128100_13601015.0RepeatNote=Nebulin 3
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128137_17201015.0RepeatNote=Nebulin 4
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128173_20501015.0RepeatNote=Nebulin 5
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128206_24101015.0RepeatNote=Nebulin 6
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128242_27801015.0RepeatNote=Nebulin 7
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128279_31301015.0RepeatNote=Nebulin 8
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-12829_6301015.0RepeatNote=Nebulin 1
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128314_34801015.0RepeatNote=Nebulin 9
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128349_38501015.0RepeatNote=Nebulin 10
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128386_42201015.0RepeatNote=Nebulin 11
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128423_45901015.0RepeatNote=Nebulin 12
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128460_49601015.0RepeatNote=Nebulin 13
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128497_53301015.0RepeatNote=Nebulin 14
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128534_56901015.0RepeatNote=Nebulin 15
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128570_59901015.0RepeatNote=Nebulin 16
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128600_63501015.0RepeatNote=Nebulin 17
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128636_66601015.0RepeatNote=Nebulin 18
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-12864_9901015.0RepeatNote=Nebulin 2
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128667_69301015.0RepeatNote=Nebulin 19
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128694_72801015.0RepeatNote=Nebulin 20
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128729_75901015.0RepeatNote=Nebulin 21
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128760_79401015.0RepeatNote=Nebulin 22
HgeneNEBLchr10:21250601chr10:22095028ENST00000377122-128795_83001015.0RepeatNote=Nebulin 23
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47100_136119271.0RepeatNote=Nebulin 3
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47137_172119271.0RepeatNote=Nebulin 4
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47173_205119271.0RepeatNote=Nebulin 5
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47206_241119271.0RepeatNote=Nebulin 6
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47242_278119271.0RepeatNote=Nebulin 7
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47279_313119271.0RepeatNote=Nebulin 8
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47314_348119271.0RepeatNote=Nebulin 9
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47349_385119271.0RepeatNote=Nebulin 10
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47386_422119271.0RepeatNote=Nebulin 11
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47423_459119271.0RepeatNote=Nebulin 12
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47460_496119271.0RepeatNote=Nebulin 13
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47497_533119271.0RepeatNote=Nebulin 14
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47534_569119271.0RepeatNote=Nebulin 15
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47570_599119271.0RepeatNote=Nebulin 16
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47600_635119271.0RepeatNote=Nebulin 17
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47636_666119271.0RepeatNote=Nebulin 18
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47667_693119271.0RepeatNote=Nebulin 19
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47694_728119271.0RepeatNote=Nebulin 20
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47729_759119271.0RepeatNote=Nebulin 21
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47760_794119271.0RepeatNote=Nebulin 22
HgeneNEBLchr10:21250601chr10:22095028ENST00000417816-47795_830119271.0RepeatNote=Nebulin 23
TgeneDNAJC1chr10:21177026chr10:22055238ENST00000376980812325_379366555.0DomainSANT 1
TgeneDNAJC1chr10:21177026chr10:22055238ENST0000037698081265_129366555.0DomainJ
TgeneDNAJC1chr10:21250601chr10:22095028ENST0000037698071265_129326555.0DomainJ
TgeneDNAJC1chr10:21177026chr10:22055238ENST00000376980812175_554366555.0Topological domainCytoplasmic
TgeneDNAJC1chr10:21177026chr10:22055238ENST0000037698081248_153366555.0Topological domainLumenal
TgeneDNAJC1chr10:21250601chr10:22095028ENST00000376980712175_554326555.0Topological domainCytoplasmic
TgeneDNAJC1chr10:21250601chr10:22095028ENST0000037698071248_153326555.0Topological domainLumenal
TgeneDNAJC1chr10:21177026chr10:22055238ENST00000376980812154_174366555.0TransmembraneHelical
TgeneDNAJC1chr10:21250601chr10:22095028ENST00000376980712154_174326555.0TransmembraneHelical


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Fusion Gene Sequence for NEBL-DNAJC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58342_58342_1_NEBL-DNAJC1_NEBL_chr10_21177026_ENST00000377119_DNAJC1_chr10_22055238_ENST00000376980_length(transcript)=1096nt_BP=379nt
AAGGGTAAAAATGAGGGTCCCTGTATTTGAGGATATAAAAGATGAAACTGAAGAAGAAAAGATAGGGGAAGAAGAAAATGAAGAAGACCA
GGTCTTCTATAAGCCTGTTATTGAAGACTTAAGCATGGAATTGGCCAGAAAATGCACGGAACTCATTAGCGATATCCGTTATAAAGAAGA
GTTTAAAAAGTCCAAGGATAAGTGTACATTTGTGACTGACAGTCCTATGCTAAACCATGTAAAAAATATCGGTGCTTTTATTTCTGAGGC
AAAATACAAAGGCACCATTAAAGCTGACCTTTCTAATTCTCTTTATAAGCGGATGCCAGCCACAATTGACAGTGTTTTTGCAGGAGAAGT
TACACAGCTCCAGAGTGAGGTGACAACCAAAGCCAAGCAACTGAAGGATTCAGTGACCTGCTCCCCAGGAATGGTTAGACTCTCCGAACT
CAAATCGACAGTTCAGAATTCCAGGCCCATCAAAACGGCCACCACCTTGCCCGATGACATGATCACCCAGCGAGAGGACGCAGAGGGGGT
GGCAGCGGAGGAGGAGCAGGAGGGAGACTCCGGTGAGCAGGAGACCGGGGCCACTGATGCCCGGCCTCGGAGGCGGAAGCCAGCCAGGCT
GCTGGAGGCTACAGCGAAGCCGGAGCCAGAGGAGAAGTCCAGAGCCAAGCGGCAGAAGGACTTTGACATAGCAGAACAAAACGAGTCCAG
CGACGAGGAGAGCCTGAGAAAAGAGAGAGCTCGGTCTGCAGAGGAGCCGTGGACTCAAAATCAACAGAAACTTCTGGAACTGGCGTTGCA
GCAGTACCCAAGGGGATCCTCTGACCGCTGGGACAAAATAGCCAGATGTGTCCCGTCCAAGAGCAAGGAAGACTGTATCGCTAGGTACAA
GTTGCTGGTTGAACTGGTCCAAAAGAAAAAACAAGCTAAAAGCTGAATATTCTGGGAGATGATGTTCACCTTCATTTTCCAAAATGAATA
TCTTAAAAATCTTATGCAGAAATTTGCATTTTGTACCTCAATATTTCTACGTCATGTGCCTTAGTAAAAAAAAATAATAAATAAATAAAA

>58342_58342_1_NEBL-DNAJC1_NEBL_chr10_21177026_ENST00000377119_DNAJC1_chr10_22055238_ENST00000376980_length(amino acids)=311AA_BP=123
MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYK
GTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVAAE
EEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQYP

--------------------------------------------------------------
>58342_58342_2_NEBL-DNAJC1_NEBL_chr10_21177026_ENST00000377122_DNAJC1_chr10_22055238_ENST00000376980_length(transcript)=1483nt_BP=766nt
CTTGAGTGTTAGAGCTGAGTAGTTTTCCCAGAATCTCTAAGTCCTTTTTATGCTCTTTTATGAATGAATAGAATTAGTAAAAGATAAATA
AATTTTTTCTTTTGGATTTCTTAACCAGTGGAAAAAATGTTGACTTTAAAAGTTCATAAAATCAAATTTTGCTTAAGAATATGTTATTTC
CACTTGTGAGGCCAGCCTGGTAGACCTCTGGGATCCTTTTCTGTTCACTCACACACCACTGAGATAAGGAGTGAAGTGTGGGCTAAATAG
GGCTGAGGCTTGGGCAAGGGCATTTCTGCCAGAGCACCAGAGACGTCAGCATCTCAAGGGCACTGTGGTATGGAAAAGGACGCCACATGA
GTAAATTTTAAAAATATAAATATTTTAAAGGGTAAAAATGAGGGTCCCTGTATTTGAGGATATAAAAGATGAAACTGAAGAAGAAAAGAT
AGGGGAAGAAGAAAATGAAGAAGACCAGGTCTTCTATAAGCCTGTTATTGAAGACTTAAGCATGGAATTGGCCAGAAAATGCACGGAACT
CATTAGCGATATCCGTTATAAAGAAGAGTTTAAAAAGTCCAAGGATAAGTGTACATTTGTGACTGACAGTCCTATGCTAAACCATGTAAA
AAATATCGGTGCTTTTATTTCTGAGGCAAAATACAAAGGCACCATTAAAGCTGACCTTTCTAATTCTCTTTATAAGCGGATGCCAGCCAC
AATTGACAGTGTTTTTGCAGGAGAAGTTACACAGCTCCAGAGTGAGGTGACAACCAAAGCCAAGCAACTGAAGGATTCAGTGACCTGCTC
CCCAGGAATGGTTAGACTCTCCGAACTCAAATCGACAGTTCAGAATTCCAGGCCCATCAAAACGGCCACCACCTTGCCCGATGACATGAT
CACCCAGCGAGAGGACGCAGAGGGGGTGGCAGCGGAGGAGGAGCAGGAGGGAGACTCCGGTGAGCAGGAGACCGGGGCCACTGATGCCCG
GCCTCGGAGGCGGAAGCCAGCCAGGCTGCTGGAGGCTACAGCGAAGCCGGAGCCAGAGGAGAAGTCCAGAGCCAAGCGGCAGAAGGACTT
TGACATAGCAGAACAAAACGAGTCCAGCGACGAGGAGAGCCTGAGAAAAGAGAGAGCTCGGTCTGCAGAGGAGCCGTGGACTCAAAATCA
ACAGAAACTTCTGGAACTGGCGTTGCAGCAGTACCCAAGGGGATCCTCTGACCGCTGGGACAAAATAGCCAGATGTGTCCCGTCCAAGAG
CAAGGAAGACTGTATCGCTAGGTACAAGTTGCTGGTTGAACTGGTCCAAAAGAAAAAACAAGCTAAAAGCTGAATATTCTGGGAGATGAT
GTTCACCTTCATTTTCCAAAATGAATATCTTAAAAATCTTATGCAGAAATTTGCATTTTGTACCTCAATATTTCTACGTCATGTGCCTTA

>58342_58342_2_NEBL-DNAJC1_NEBL_chr10_21177026_ENST00000377122_DNAJC1_chr10_22055238_ENST00000376980_length(amino acids)=311AA_BP=123
MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYK
GTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVAAE
EEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQYP

--------------------------------------------------------------
>58342_58342_3_NEBL-DNAJC1_NEBL_chr10_21250601_ENST00000377159_DNAJC1_chr10_22095028_ENST00000376980_length(transcript)=1094nt_BP=257nt
AGATGCTTCATTTCTATTATGAGTGGCTGCATTCTGGCTCCAGGGGCGCAGTCCCTAAGCCGCTACACTACCCGAAGCAGTCCTTCACCA
CGGTGGCAGATACACCTGAAAATCTTCGCCTGAAGCAGCAAAGTGAATTGCAGAGTCAGGTCAAGTACAAAAGAGATTTTGAAGAAAGCA
AAGGGAGGGGCTTCAGCATCGTCACGGACACTCCTGAGCTACAGAGACTGAAGAGGACTCAGGAGCAAATCAGTAATGCACCTGAATGGA
CAGAAGAGGACCTCAGCCAACTGACAAGAAGTATGGTTAAGTTCCCAGGAGGGACTCCAGGTCGATGGGAAAAGATTGCCCACGAATTGG
GTCGATCTGTGACAGATGTGACAACCAAAGCCAAGCAACTGAAGGATTCAGTGACCTGCTCCCCAGGAATGGTTAGACTCTCCGAACTCA
AATCGACAGTTCAGAATTCCAGGCCCATCAAAACGGCCACCACCTTGCCCGATGACATGATCACCCAGCGAGAGGACGCAGAGGGGGTGG
CAGCGGAGGAGGAGCAGGAGGGAGACTCCGGTGAGCAGGAGACCGGGGCCACTGATGCCCGGCCTCGGAGGCGGAAGCCAGCCAGGCTGC
TGGAGGCTACAGCGAAGCCGGAGCCAGAGGAGAAGTCCAGAGCCAAGCGGCAGAAGGACTTTGACATAGCAGAACAAAACGAGTCCAGCG
ACGAGGAGAGCCTGAGAAAAGAGAGAGCTCGGTCTGCAGAGGAGCCGTGGACTCAAAATCAACAGAAACTTCTGGAACTGGCGTTGCAGC
AGTACCCAAGGGGATCCTCTGACCGCTGGGACAAAATAGCCAGATGTGTCCCGTCCAAGAGCAAGGAAGACTGTATCGCTAGGTACAAGT
TGCTGGTTGAACTGGTCCAAAAGAAAAAACAAGCTAAAAGCTGAATATTCTGGGAGATGATGTTCACCTTCATTTTCCAAAATGAATATC
TTAAAAATCTTATGCAGAAATTTGCATTTTGTACCTCAATATTTCTACGTCATGTGCCTTAGTAAAAAAAAATAATAAATAAATAAAAGA

>58342_58342_3_NEBL-DNAJC1_NEBL_chr10_21250601_ENST00000377159_DNAJC1_chr10_22095028_ENST00000376980_length(amino acids)=313AA_BP=85
MLHFYYEWLHSGSRGAVPKPLHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDFEESKGRGFSIVTDTPELQRLKRTQEQISNAPEWT
EEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRLSELKSTVQNSRPIKTATTLPDDMITQREDAEGVA
AEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQNESSDEESLRKERARSAEEPWTQNQQKLLELALQQ

--------------------------------------------------------------
>58342_58342_4_NEBL-DNAJC1_NEBL_chr10_21250601_ENST00000417816_DNAJC1_chr10_22095028_ENST00000376980_length(transcript)=1548nt_BP=711nt
CCTGCGCGGCGGCGGCGGCGAGGCGGGGGAGCGAGTGAGCGCGAGGGGCGGGCGCGAGTGACTGTGTGAGTCACCCGTACCTGGAGTGCG
AGCGACGCAGAGCCAGCGGCGCGGAGCCGGAGCCGGAGCCGAGACCCAGCGCCTGCGAGCCCGAGAGCGCGGCCGGCCCCAGGCGCCAGG
CCCCGTCGCCCTCCCCGTGCACTCACCCGTGGCCCGGCGCCGACTCCCTACCCGGCGCCCGCCGCCCGCAGCCCTCCCGCCTGCCAGGAG
GCGGTGCGGGGCTCGCCGGGGGATGTCACAGCGGCTCCTGGGAGCCAGCAGCCGCCGCCGCCGCCGCCCCCGGGAACCGCGATCATGAAC
CCCCAGTGCGCCCGTTGCGGAAAAGTCGTGTATCCCACCGAGAAAGTCAACTGCCTGGATAAGTATTGGCATAAAGGATGTTTCCATTGT
GAGGTCTGCAAGATGGCACTCAACATGAACAACTACAAAGGCTATGAAAAGAAGCCCTATTGTAATGCACACTACCCGAAGCAGTCCTTC
ACCACGGTGGCAGATACACCTGAAAATCTTCGCCTGAAGCAGCAAAGTGAATTGCAGAGTCAGGTCAAGTACAAAAGAGATTTTGAAGAA
AGCAAAGGGAGGGGCTTCAGCATCGTCACGGACACTCCTGAGCTACAGAGACTGAAGAGGACTCAGGAGCAAATCAGTAATGCACCTGAA
TGGACAGAAGAGGACCTCAGCCAACTGACAAGAAGTATGGTTAAGTTCCCAGGAGGGACTCCAGGTCGATGGGAAAAGATTGCCCACGAA
TTGGGTCGATCTGTGACAGATGTGACAACCAAAGCCAAGCAACTGAAGGATTCAGTGACCTGCTCCCCAGGAATGGTTAGACTCTCCGAA
CTCAAATCGACAGTTCAGAATTCCAGGCCCATCAAAACGGCCACCACCTTGCCCGATGACATGATCACCCAGCGAGAGGACGCAGAGGGG
GTGGCAGCGGAGGAGGAGCAGGAGGGAGACTCCGGTGAGCAGGAGACCGGGGCCACTGATGCCCGGCCTCGGAGGCGGAAGCCAGCCAGG
CTGCTGGAGGCTACAGCGAAGCCGGAGCCAGAGGAGAAGTCCAGAGCCAAGCGGCAGAAGGACTTTGACATAGCAGAACAAAACGAGTCC
AGCGACGAGGAGAGCCTGAGAAAAGAGAGAGCTCGGTCTGCAGAGGAGCCGTGGACTCAAAATCAACAGAAACTTCTGGAACTGGCGTTG
CAGCAGTACCCAAGGGGATCCTCTGACCGCTGGGACAAAATAGCCAGATGTGTCCCGTCCAAGAGCAAGGAAGACTGTATCGCTAGGTAC
AAGTTGCTGGTTGAACTGGTCCAAAAGAAAAAACAAGCTAAAAGCTGAATATTCTGGGAGATGATGTTCACCTTCATTTTCCAAAATGAA
TATCTTAAAAATCTTATGCAGAAATTTGCATTTTGTACCTCAATATTTCTACGTCATGTGCCTTAGTAAAAAAAAATAATAAATAAATAA

>58342_58342_4_NEBL-DNAJC1_NEBL_chr10_21250601_ENST00000417816_DNAJC1_chr10_22095028_ENST00000376980_length(amino acids)=347AA_BP=119
MNPQCARCGKVVYPTEKVNCLDKYWHKGCFHCEVCKMALNMNNYKGYEKKPYCNAHYPKQSFTTVADTPENLRLKQQSELQSQVKYKRDF
EESKGRGFSIVTDTPELQRLKRTQEQISNAPEWTEEDLSQLTRSMVKFPGGTPGRWEKIAHELGRSVTDVTTKAKQLKDSVTCSPGMVRL
SELKSTVQNSRPIKTATTLPDDMITQREDAEGVAAEEEQEGDSGEQETGATDARPRRRKPARLLEATAKPEPEEKSRAKRQKDFDIAEQN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NEBL-DNAJC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEBL-DNAJC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEBL-DNAJC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource