FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NEBL-FBXO11 (FusionGDB2 ID:58343)

Fusion Gene Summary for NEBL-FBXO11

check button Fusion gene summary
Fusion gene informationFusion gene name: NEBL-FBXO11
Fusion gene ID: 58343
HgeneTgene
Gene symbol

NEBL

FBXO11

Gene ID

10529

80204

Gene namenebuletteF-box protein 11
SynonymsC10orf113|LASP2|LNEBL|bA165O3.1FBX11|IDDFBA|PRMT9|UBR6|UG063H01|VIT1
Cytomap

10p12.31

2p16.3

Type of geneprotein-codingprotein-coding
DescriptionnebuletteLIM and SH3 protein 2LIM-nebuletteactin-binding Z-disk proteinF-box only protein 11protein arginine N-methyltransferase 9ubiquitin protein ligase E3 component n-recognin 6vitiligo-associated protein 1vitiligo-associated protein VIT-1
Modification date2020031320200327
UniProtAcc

O76041

Q86XK2

Ensembl transtripts involved in fusion geneENST00000377119, ENST00000377122, 
ENST00000377159, ENST00000417816, 
ENST00000464278, 		ENST00000316377, 
ENST00000378314, ENST00000402508, 
ENST00000403359, ENST00000480038, 
ENST00000405808, ENST00000434523, 
Fusion gene scores* DoF score15 X 12 X 6=10808 X 12 X 6=576
# samples 1615
** MAII scorelog2(16/1080*10)=-2.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/576*10)=-1.94110631094643
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEBL [Title/Abstract] AND FBXO11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEBL(21169723)-FBXO11(48066908), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFBXO11

GO:0006464

cellular protein modification process

16487488


check buttonFusion gene breakpoints across NEBL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across FBXO11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A7-A13D-01ANEBLchr10

21169723

-FBXO11chr2

48066908

-
ChimerDB4BRCATCGA-A7-A13D-01BNEBLchr10

21169723

-FBXO11chr2

48066908

-
ChimerDB4BRCATCGA-A7-A13DNEBLchr10

21169722

-FBXO11chr2

48066908

-


Top

Fusion Gene ORF analysis for NEBL-FBXO11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000377119ENST00000316377NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000316377NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000378314NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000378314NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000402508NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000402508NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000403359NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000403359NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000480038NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377119ENST00000480038NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000316377NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000316377NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000378314NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000378314NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000402508NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000402508NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000403359NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000403359NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000480038NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-5UTRENST00000377122ENST00000480038NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-intronENST00000377119ENST00000405808NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-intronENST00000377119ENST00000405808NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-intronENST00000377119ENST00000434523NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-intronENST00000377119ENST00000434523NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-intronENST00000377122ENST00000405808NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-intronENST00000377122ENST00000405808NEBLchr10

21169722

-FBXO11chr2

48066908

-
5CDS-intronENST00000377122ENST00000434523NEBLchr10

21169723

-FBXO11chr2

48066908

-
5CDS-intronENST00000377122ENST00000434523NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000316377NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000316377NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000378314NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000378314NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000402508NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000402508NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000403359NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000403359NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000480038NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000377159ENST00000480038NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000316377NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000316377NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000378314NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000378314NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000402508NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000402508NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000403359NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000403359NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000480038NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000417816ENST00000480038NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000316377NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000316377NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000378314NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000378314NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000402508NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000402508NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000403359NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000403359NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000480038NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-5UTRENST00000464278ENST00000480038NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-intronENST00000377159ENST00000405808NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-intronENST00000377159ENST00000405808NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-intronENST00000377159ENST00000434523NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-intronENST00000377159ENST00000434523NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-intronENST00000417816ENST00000405808NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-intronENST00000417816ENST00000405808NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-intronENST00000417816ENST00000434523NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-intronENST00000417816ENST00000434523NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-intronENST00000464278ENST00000405808NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-intronENST00000464278ENST00000405808NEBLchr10

21169722

-FBXO11chr2

48066908

-
intron-intronENST00000464278ENST00000434523NEBLchr10

21169723

-FBXO11chr2

48066908

-
intron-intronENST00000464278ENST00000434523NEBLchr10

21169722

-FBXO11chr2

48066908

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for NEBL-FBXO11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for NEBL-FBXO11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21169723/:48066908)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEBL

O76041

FBXO11

Q86XK2

FUNCTION: Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres (PubMed:27733623). Isoform 2 might play a role in the assembly of focal adhesion (PubMed:15004028). {ECO:0000269|PubMed:15004028, ECO:0000269|PubMed:27733623}.FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. {ECO:0000269|PubMed:17098746, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23478441, ECO:0000269|PubMed:23478445, ECO:0000269|PubMed:23892434, ECO:0000269|PubMed:24613396}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for NEBL-FBXO11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for NEBL-FBXO11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NEBL-FBXO11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NEBL-FBXO11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource