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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NECAP2-EPHA2 (FusionGDB2 ID:58376)

Fusion Gene Summary for NECAP2-EPHA2

check button Fusion gene summary
Fusion gene informationFusion gene name: NECAP2-EPHA2
Fusion gene ID: 58376
HgeneTgene
Gene symbol

NECAP2

EPHA2

Gene ID

55707

1969

Gene nameNECAP endocytosis associated 2EPH receptor A2
Synonyms-ARCC2|CTPA|CTPP1|CTRCT6|ECK
Cytomap

1p36.13

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionadaptin ear-binding coat-associated protein 2adaptin-ear-binding coat-associated protein 2ephrin type-A receptor 2epithelial cell receptor protein tyrosine kinasesoluble EPHA2 variant 1tyrosine-protein kinase receptor ECK
Modification date2020031320200313
UniProtAcc.

P29317

Ensembl transtripts involved in fusion geneENST00000337132, ENST00000406746, 
ENST00000443980, ENST00000457722, 
ENST00000504551, ENST00000486390, 
ENST00000461614, ENST00000358432, 
Fusion gene scores* DoF score3 X 4 X 2=245 X 4 X 5=100
# samples 45
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NECAP2 [Title/Abstract] AND EPHA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNECAP2(16775696)-EPHA2(16456914), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneEPHA2

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

18339848

TgeneEPHA2

GO:0033628

regulation of cell adhesion mediated by integrin

10655584

TgeneEPHA2

GO:0043491

protein kinase B signaling

19573808

TgeneEPHA2

GO:0048013

ephrin receptor signaling pathway

10655584|20861311

TgeneEPHA2

GO:0051898

negative regulation of protein kinase B signaling

19573808


check buttonFusion gene breakpoints across NECAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across EPHA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-2400-01ANECAP2chr1

16775696

-EPHA2chr1

16456914

-
ChimerDB4OVTCGA-25-2400-01ANECAP2chr1

16775696

+EPHA2chr1

16456914

-


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Fusion Gene ORF analysis for NECAP2-EPHA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000337132ENST00000461614NECAP2chr1

16775696

+EPHA2chr1

16456914

-
5CDS-intronENST00000406746ENST00000461614NECAP2chr1

16775696

+EPHA2chr1

16456914

-
5CDS-intronENST00000443980ENST00000461614NECAP2chr1

16775696

+EPHA2chr1

16456914

-
5CDS-intronENST00000457722ENST00000461614NECAP2chr1

16775696

+EPHA2chr1

16456914

-
5CDS-intronENST00000504551ENST00000461614NECAP2chr1

16775696

+EPHA2chr1

16456914

-
In-frameENST00000337132ENST00000358432NECAP2chr1

16775696

+EPHA2chr1

16456914

-
In-frameENST00000406746ENST00000358432NECAP2chr1

16775696

+EPHA2chr1

16456914

-
In-frameENST00000443980ENST00000358432NECAP2chr1

16775696

+EPHA2chr1

16456914

-
In-frameENST00000457722ENST00000358432NECAP2chr1

16775696

+EPHA2chr1

16456914

-
In-frameENST00000504551ENST00000358432NECAP2chr1

16775696

+EPHA2chr1

16456914

-
intron-3CDSENST00000486390ENST00000358432NECAP2chr1

16775696

+EPHA2chr1

16456914

-
intron-intronENST00000486390ENST00000461614NECAP2chr1

16775696

+EPHA2chr1

16456914

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000337132NECAP2chr116775696+ENST00000358432EPHA2chr116456914-1913579901034314
ENST00000504551NECAP2chr116775696+ENST00000358432EPHA2chr116456914-168134741802253
ENST00000457722NECAP2chr116775696+ENST00000358432EPHA2chr116456914-178344938904288
ENST00000406746NECAP2chr116775696+ENST00000358432EPHA2chr116456914-186152738982314
ENST00000443980NECAP2chr116775696+ENST00000358432EPHA2chr116456914-184951526970314

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000337132ENST00000358432NECAP2chr116775696+EPHA2chr116456914-0.0066040090.993396
ENST00000504551ENST00000358432NECAP2chr116775696+EPHA2chr116456914-0.038384890.9616151
ENST00000457722ENST00000358432NECAP2chr116775696+EPHA2chr116456914-0.007440910.9925591
ENST00000406746ENST00000358432NECAP2chr116775696+EPHA2chr116456914-0.006515180.9934848
ENST00000443980ENST00000358432NECAP2chr116775696+EPHA2chr116456914-0.0066085090.9933915

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Fusion Genomic Features for NECAP2-EPHA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NECAP2-EPHA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:16775696/chr1:16456914)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EPHA2

P29317

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:16236711, ECO:0000269|PubMed:18339848, ECO:0000269|PubMed:19573808, ECO:0000269|PubMed:20679435, ECO:0000269|PubMed:20861311, ECO:0000269|PubMed:23358419, ECO:0000269|PubMed:26158630, ECO:0000269|PubMed:27385333}.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins. {ECO:0000269|PubMed:21516087}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317904_968825977.0DomainSAM
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317974_976825977.0MotifPDZ-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNECAP2chr1:16775696chr1:16456914ENST00000337132+58240_243163264.0MotifNote=WXXF motif 1
HgeneNECAP2chr1:16775696chr1:16456914ENST00000337132+58260_263163264.0MotifNote=WXXF motif 2
HgeneNECAP2chr1:16775696chr1:16456914ENST00000406746+59240_243163321.0MotifNote=WXXF motif 1
HgeneNECAP2chr1:16775696chr1:16456914ENST00000406746+59260_263163321.0MotifNote=WXXF motif 2
HgeneNECAP2chr1:16775696chr1:16456914ENST00000443980+57240_243163274.0MotifNote=WXXF motif 1
HgeneNECAP2chr1:16775696chr1:16456914ENST00000443980+57260_263163274.0MotifNote=WXXF motif 2
HgeneNECAP2chr1:16775696chr1:16456914ENST00000457722+58240_243137238.0MotifNote=WXXF motif 1
HgeneNECAP2chr1:16775696chr1:16456914ENST00000457722+58260_263137238.0MotifNote=WXXF motif 2
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317188_325825977.0Compositional biasNote=Cys-rich
TgeneEPHA2chr1:16775696chr1:16456914ENST00000358432131728_206825977.0DomainEph LBD
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317328_432825977.0DomainFibronectin type-III 1
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317438_529825977.0DomainFibronectin type-III 2
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317613_875825977.0DomainProtein kinase
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317619_627825977.0Nucleotide bindingATP
TgeneEPHA2chr1:16775696chr1:16456914ENST00000358432131724_537825977.0Topological domainExtracellular
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317559_976825977.0Topological domainCytoplasmic
TgeneEPHA2chr1:16775696chr1:16456914ENST000003584321317538_558825977.0TransmembraneHelical


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Fusion Gene Sequence for NECAP2-EPHA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58376_58376_1_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000337132_EPHA2_chr1_16456914_ENST00000358432_length(transcript)=1913nt_BP=579nt
GAAACCTGGTCAGAGAGTCGCACCGCTTCCGTCCGTCGGACAGAGGAACGGTGGAAGTCGCCGGAAGTTCGGTGGGCTCCAGGCGTCGCG
ATGGAGGAGAGCGGGTACGAGTCGGTGCTCTGTGTCAAGCCTGACGTCCACGTCTACCGCATCCCTCCGCGGGCTACCAACCGTGGCTAC
AGGGCTGCGGAGTGGCAGCTGGACCAGCCATCATGGAGTGGCCGGCTGAGGATCACTGCAAAGGGACAGATGGCCTACATCAAGCTGGAG
GACAGGACGTCAGGGGAGCTCTTTGCTCAGGCCCCGGTGGATCAGTTTCCTGGCACAGCTGTGGAGAGTGTGACGGATTCCAGCAGGTAC
TTCGTGATCCGCATCGAAGATGGAAATGGGCGACGGGCGTTTATTGGAATTGGCTTCGGGGACCGAGGTGATGCCTTTGACTTCAATGTT
GCATTGCAGGACCATTTCAAGTGGGTGAAACAGCAGTGTGAATTTGCAAAACAAGCCCAGAACCCAGACCAAGGCCCTAAACTGGACCTG
GGCTTCAAGGAGGGCCAGACCATCAAGCTCAACATCGCAGTGATGAAAGCCATCAATGATGGCTTCCGGCTCCCCACACCCATGGACTGC
CCCTCCGCCATCTACCAGCTCATGATGCAGTGCTGGCAGCAGGAGCGTGCCCGCCGCCCCAAGTTCGCTGACATCGTCAGCATCCTGGAC
AAGCTCATTCGTGCCCCTGACTCCCTCAAGACCCTGGCTGACTTTGACCCCCGCGTGTCTATCCGGCTCCCCAGCACGAGCGGCTCGGAG
GGGGTGCCCTTCCGCACGGTGTCCGAGTGGCTGGAGTCCATCAAGATGCAGCAGTATACGGAGCACTTCATGGCGGCCGGCTACACTGCC
ATCGAGAAGGTGGTGCAGATGACCAACGACGACATCAAGAGGATTGGGGTGCGGCTGCCCGGCCACCAGAAGCGCATCGCCTACAGCCTG
CTGGGACTCAAGGACCAGGTGAACACTGTGGGGATCCCCATCTGAGCCTCGACAGGGCCTGGAGCCCCATCGGCCAAGAATACTTGAAGA
AACAGAGTGGCCTCCCTGCTGTGCCATGCTGGGCCACTGGGGACTTTATTTATTTCTAGTTCTTTCCTCCCCCTGCAACTTCCGCTGAGG
GGTCTCGGATGACACCCTGGCCTGAACTGAGGAGATGACCAGGGATGCTGGGCTGGGCCCTCTTTCCCTGCGAGACGCACACAGCTGAGC
ACTTAGCAGGCACCGCCACGTCCCAGCATCCCTGGAGCAGGAGCCCCGCCACAGCCTTCGGACAGACATATGGGATATTCCCAAGCCGAC
CTTCCCTCCGCCTTCTCCCACATGAGGCCATCTCAGGAGATGGAGGGCTTGGCCCAGCGCCAAGTAAACAGGGTACCTCAAGCCCCATTT
CCTCACACTAAGAGGGCAGACTGTGAACTTGACTGGGTGAGACCCAAAGCGGTCCCTGTCCCTCTAGTGCCTTCTTTAGACCCTCGGGCC
CCATCCTCATCCCTGACTGGCCAAACCCTTGCTTTCCTGGGCCTTTGCAAGATGCTTGGTTGTGTTGAGGTTTTTAAATATATATTTTGT
ACTTTGTGGAGAGAATGTGTGTGTGTGGCAGGGGGCCCCGCCAGGGCTGGGGACAGAGGGTGTCAAACATTCGTGAGCTGGGGACTCAGG
GACCGGTGCTGCAGGAGTGTCCTGCCCATGCCCCAGTCGGCCCCATCTCTCATCCTTTTGGATAAGTTTCTATTCTGTCAGTGTTAAAGA
TTTTGTTTTGTTGGACATTTTTTTCGAATCTTAATTTATTATTTTTTTTATATTTATTGTTAGAAAATGACTTATTTCTGCTCTGGAATA

>58376_58376_1_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000337132_EPHA2_chr1_16456914_ENST00000358432_length(amino acids)=314AA_BP=163
MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRY
FVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIAVMKAINDGFRLPTPMDC
PSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTA

--------------------------------------------------------------
>58376_58376_2_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000406746_EPHA2_chr1_16456914_ENST00000358432_length(transcript)=1861nt_BP=527nt
GGAAGTCGCCGGAAGTTCGGTGGGCTCCAGGCGTCGCGATGGAGGAGAGCGGGTACGAGTCGGTGCTCTGTGTCAAGCCTGACGTCCACG
TCTACCGCATCCCTCCGCGGGCTACCAACCGTGGCTACAGGGCTGCGGAGTGGCAGCTGGACCAGCCATCATGGAGTGGCCGGCTGAGGA
TCACTGCAAAGGGACAGATGGCCTACATCAAGCTGGAGGACAGGACGTCAGGGGAGCTCTTTGCTCAGGCCCCGGTGGATCAGTTTCCTG
GCACAGCTGTGGAGAGTGTGACGGATTCCAGCAGGTACTTCGTGATCCGCATCGAAGATGGAAATGGGCGACGGGCGTTTATTGGAATTG
GCTTCGGGGACCGAGGTGATGCCTTTGACTTCAATGTTGCATTGCAGGACCATTTCAAGTGGGTGAAACAGCAGTGTGAATTTGCAAAAC
AAGCCCAGAACCCAGACCAAGGCCCTAAACTGGACCTGGGCTTCAAGGAGGGCCAGACCATCAAGCTCAACATCGCAGTGATGAAAGCCA
TCAATGATGGCTTCCGGCTCCCCACACCCATGGACTGCCCCTCCGCCATCTACCAGCTCATGATGCAGTGCTGGCAGCAGGAGCGTGCCC
GCCGCCCCAAGTTCGCTGACATCGTCAGCATCCTGGACAAGCTCATTCGTGCCCCTGACTCCCTCAAGACCCTGGCTGACTTTGACCCCC
GCGTGTCTATCCGGCTCCCCAGCACGAGCGGCTCGGAGGGGGTGCCCTTCCGCACGGTGTCCGAGTGGCTGGAGTCCATCAAGATGCAGC
AGTATACGGAGCACTTCATGGCGGCCGGCTACACTGCCATCGAGAAGGTGGTGCAGATGACCAACGACGACATCAAGAGGATTGGGGTGC
GGCTGCCCGGCCACCAGAAGCGCATCGCCTACAGCCTGCTGGGACTCAAGGACCAGGTGAACACTGTGGGGATCCCCATCTGAGCCTCGA
CAGGGCCTGGAGCCCCATCGGCCAAGAATACTTGAAGAAACAGAGTGGCCTCCCTGCTGTGCCATGCTGGGCCACTGGGGACTTTATTTA
TTTCTAGTTCTTTCCTCCCCCTGCAACTTCCGCTGAGGGGTCTCGGATGACACCCTGGCCTGAACTGAGGAGATGACCAGGGATGCTGGG
CTGGGCCCTCTTTCCCTGCGAGACGCACACAGCTGAGCACTTAGCAGGCACCGCCACGTCCCAGCATCCCTGGAGCAGGAGCCCCGCCAC
AGCCTTCGGACAGACATATGGGATATTCCCAAGCCGACCTTCCCTCCGCCTTCTCCCACATGAGGCCATCTCAGGAGATGGAGGGCTTGG
CCCAGCGCCAAGTAAACAGGGTACCTCAAGCCCCATTTCCTCACACTAAGAGGGCAGACTGTGAACTTGACTGGGTGAGACCCAAAGCGG
TCCCTGTCCCTCTAGTGCCTTCTTTAGACCCTCGGGCCCCATCCTCATCCCTGACTGGCCAAACCCTTGCTTTCCTGGGCCTTTGCAAGA
TGCTTGGTTGTGTTGAGGTTTTTAAATATATATTTTGTACTTTGTGGAGAGAATGTGTGTGTGTGGCAGGGGGCCCCGCCAGGGCTGGGG
ACAGAGGGTGTCAAACATTCGTGAGCTGGGGACTCAGGGACCGGTGCTGCAGGAGTGTCCTGCCCATGCCCCAGTCGGCCCCATCTCTCA
TCCTTTTGGATAAGTTTCTATTCTGTCAGTGTTAAAGATTTTGTTTTGTTGGACATTTTTTTCGAATCTTAATTTATTATTTTTTTTATA

>58376_58376_2_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000406746_EPHA2_chr1_16456914_ENST00000358432_length(amino acids)=314AA_BP=163
MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRY
FVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIAVMKAINDGFRLPTPMDC
PSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTA

--------------------------------------------------------------
>58376_58376_3_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000443980_EPHA2_chr1_16456914_ENST00000358432_length(transcript)=1849nt_BP=515nt
AAGTTCGGTGGGCTCCAGGCGTCGCGATGGAGGAGAGCGGGTACGAGTCGGTGCTCTGTGTCAAGCCTGACGTCCACGTCTACCGCATCC
CTCCGCGGGCTACCAACCGTGGCTACAGGGCTGCGGAGTGGCAGCTGGACCAGCCATCATGGAGTGGCCGGCTGAGGATCACTGCAAAGG
GACAGATGGCCTACATCAAGCTGGAGGACAGGACGTCAGGGGAGCTCTTTGCTCAGGCCCCGGTGGATCAGTTTCCTGGCACAGCTGTGG
AGAGTGTGACGGATTCCAGCAGGTACTTCGTGATCCGCATCGAAGATGGAAATGGGCGACGGGCGTTTATTGGAATTGGCTTCGGGGACC
GAGGTGATGCCTTTGACTTCAATGTTGCATTGCAGGACCATTTCAAGTGGGTGAAACAGCAGTGTGAATTTGCAAAACAAGCCCAGAACC
CAGACCAAGGCCCTAAACTGGACCTGGGCTTCAAGGAGGGCCAGACCATCAAGCTCAACATCGCAGTGATGAAAGCCATCAATGATGGCT
TCCGGCTCCCCACACCCATGGACTGCCCCTCCGCCATCTACCAGCTCATGATGCAGTGCTGGCAGCAGGAGCGTGCCCGCCGCCCCAAGT
TCGCTGACATCGTCAGCATCCTGGACAAGCTCATTCGTGCCCCTGACTCCCTCAAGACCCTGGCTGACTTTGACCCCCGCGTGTCTATCC
GGCTCCCCAGCACGAGCGGCTCGGAGGGGGTGCCCTTCCGCACGGTGTCCGAGTGGCTGGAGTCCATCAAGATGCAGCAGTATACGGAGC
ACTTCATGGCGGCCGGCTACACTGCCATCGAGAAGGTGGTGCAGATGACCAACGACGACATCAAGAGGATTGGGGTGCGGCTGCCCGGCC
ACCAGAAGCGCATCGCCTACAGCCTGCTGGGACTCAAGGACCAGGTGAACACTGTGGGGATCCCCATCTGAGCCTCGACAGGGCCTGGAG
CCCCATCGGCCAAGAATACTTGAAGAAACAGAGTGGCCTCCCTGCTGTGCCATGCTGGGCCACTGGGGACTTTATTTATTTCTAGTTCTT
TCCTCCCCCTGCAACTTCCGCTGAGGGGTCTCGGATGACACCCTGGCCTGAACTGAGGAGATGACCAGGGATGCTGGGCTGGGCCCTCTT
TCCCTGCGAGACGCACACAGCTGAGCACTTAGCAGGCACCGCCACGTCCCAGCATCCCTGGAGCAGGAGCCCCGCCACAGCCTTCGGACA
GACATATGGGATATTCCCAAGCCGACCTTCCCTCCGCCTTCTCCCACATGAGGCCATCTCAGGAGATGGAGGGCTTGGCCCAGCGCCAAG
TAAACAGGGTACCTCAAGCCCCATTTCCTCACACTAAGAGGGCAGACTGTGAACTTGACTGGGTGAGACCCAAAGCGGTCCCTGTCCCTC
TAGTGCCTTCTTTAGACCCTCGGGCCCCATCCTCATCCCTGACTGGCCAAACCCTTGCTTTCCTGGGCCTTTGCAAGATGCTTGGTTGTG
TTGAGGTTTTTAAATATATATTTTGTACTTTGTGGAGAGAATGTGTGTGTGTGGCAGGGGGCCCCGCCAGGGCTGGGGACAGAGGGTGTC
AAACATTCGTGAGCTGGGGACTCAGGGACCGGTGCTGCAGGAGTGTCCTGCCCATGCCCCAGTCGGCCCCATCTCTCATCCTTTTGGATA
AGTTTCTATTCTGTCAGTGTTAAAGATTTTGTTTTGTTGGACATTTTTTTCGAATCTTAATTTATTATTTTTTTTATATTTATTGTTAGA

>58376_58376_3_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000443980_EPHA2_chr1_16456914_ENST00000358432_length(amino acids)=314AA_BP=163
MEESGYESVLCVKPDVHVYRIPPRATNRGYRAAEWQLDQPSWSGRLRITAKGQMAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRY
FVIRIEDGNGRRAFIGIGFGDRGDAFDFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIAVMKAINDGFRLPTPMDC
PSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTA

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>58376_58376_4_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000457722_EPHA2_chr1_16456914_ENST00000358432_length(transcript)=1783nt_BP=449nt
GGAAGTCGCCGGAAGTTCGGTGGGCTCCAGGCGTCGCGATGGAGGAGAGCGGGGCTGCGGAGTGGCAGCTGGACCAGCCATCATGGAGTG
GCCGGCTGAGGATCACTGCAAAGGGACAGATGGCCTACATCAAGCTGGAGGACAGGACGTCAGGGGAGCTCTTTGCTCAGGCCCCGGTGG
ATCAGTTTCCTGGCACAGCTGTGGAGAGTGTGACGGATTCCAGCAGGTACTTCGTGATCCGCATCGAAGATGGAAATGGGCGACGGGCGT
TTATTGGAATTGGCTTCGGGGACCGAGGTGATGCCTTTGACTTCAATGTTGCATTGCAGGACCATTTCAAGTGGGTGAAACAGCAGTGTG
AATTTGCAAAACAAGCCCAGAACCCAGACCAAGGCCCTAAACTGGACCTGGGCTTCAAGGAGGGCCAGACCATCAAGCTCAACATCGCAG
TGATGAAAGCCATCAATGATGGCTTCCGGCTCCCCACACCCATGGACTGCCCCTCCGCCATCTACCAGCTCATGATGCAGTGCTGGCAGC
AGGAGCGTGCCCGCCGCCCCAAGTTCGCTGACATCGTCAGCATCCTGGACAAGCTCATTCGTGCCCCTGACTCCCTCAAGACCCTGGCTG
ACTTTGACCCCCGCGTGTCTATCCGGCTCCCCAGCACGAGCGGCTCGGAGGGGGTGCCCTTCCGCACGGTGTCCGAGTGGCTGGAGTCCA
TCAAGATGCAGCAGTATACGGAGCACTTCATGGCGGCCGGCTACACTGCCATCGAGAAGGTGGTGCAGATGACCAACGACGACATCAAGA
GGATTGGGGTGCGGCTGCCCGGCCACCAGAAGCGCATCGCCTACAGCCTGCTGGGACTCAAGGACCAGGTGAACACTGTGGGGATCCCCA
TCTGAGCCTCGACAGGGCCTGGAGCCCCATCGGCCAAGAATACTTGAAGAAACAGAGTGGCCTCCCTGCTGTGCCATGCTGGGCCACTGG
GGACTTTATTTATTTCTAGTTCTTTCCTCCCCCTGCAACTTCCGCTGAGGGGTCTCGGATGACACCCTGGCCTGAACTGAGGAGATGACC
AGGGATGCTGGGCTGGGCCCTCTTTCCCTGCGAGACGCACACAGCTGAGCACTTAGCAGGCACCGCCACGTCCCAGCATCCCTGGAGCAG
GAGCCCCGCCACAGCCTTCGGACAGACATATGGGATATTCCCAAGCCGACCTTCCCTCCGCCTTCTCCCACATGAGGCCATCTCAGGAGA
TGGAGGGCTTGGCCCAGCGCCAAGTAAACAGGGTACCTCAAGCCCCATTTCCTCACACTAAGAGGGCAGACTGTGAACTTGACTGGGTGA
GACCCAAAGCGGTCCCTGTCCCTCTAGTGCCTTCTTTAGACCCTCGGGCCCCATCCTCATCCCTGACTGGCCAAACCCTTGCTTTCCTGG
GCCTTTGCAAGATGCTTGGTTGTGTTGAGGTTTTTAAATATATATTTTGTACTTTGTGGAGAGAATGTGTGTGTGTGGCAGGGGGCCCCG
CCAGGGCTGGGGACAGAGGGTGTCAAACATTCGTGAGCTGGGGACTCAGGGACCGGTGCTGCAGGAGTGTCCTGCCCATGCCCCAGTCGG
CCCCATCTCTCATCCTTTTGGATAAGTTTCTATTCTGTCAGTGTTAAAGATTTTGTTTTGTTGGACATTTTTTTCGAATCTTAATTTATT

>58376_58376_4_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000457722_EPHA2_chr1_16456914_ENST00000358432_length(amino acids)=288AA_BP=137
MEESGAAEWQLDQPSWSGRLRITAKGQMAYIKLEDRTSGELFAQAPVDQFPGTAVESVTDSSRYFVIRIEDGNGRRAFIGIGFGDRGDAF
DFNVALQDHFKWVKQQCEFAKQAQNPDQGPKLDLGFKEGQTIKLNIAVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIV
SILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEGVPFRTVSEWLESIKMQQYTEHFMAAGYTAIEKVVQMTNDDIKRIGVRLPGHQKRI

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>58376_58376_5_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000504551_EPHA2_chr1_16456914_ENST00000358432_length(transcript)=1681nt_BP=347nt
GGTGGAAGTCGCCGGAAGTTCGGTGGGCTCCAGGCGTCGCGATGGAGGAGAGCGGGTACGAGTCGGTGCTCTGTGTCAAGCCTGACGTCC
ACGTCTACCGCATCCCTCCGCGGGCTACCAACCGTGGCTACAGGGGAGCTCTTTGCTCAGGCCCCGGTGGATCAGTTTCCTGGCACAGCT
GTGGAGAGTGTGACGGATTCCAGCAGGTACTTCGTGATCCGCATCGAAGATGGAAATGGTGGGTGAAACAGCAGTGTGAATTTGCAAAAC
AAGCCCAGAACCCAGACCAAGGCCCTAAACTGGACCTGGGCTTCAAGGAGGGCCAGACCATCAAGCTCAACATCGCAGTGATGAAAGCCA
TCAATGATGGCTTCCGGCTCCCCACACCCATGGACTGCCCCTCCGCCATCTACCAGCTCATGATGCAGTGCTGGCAGCAGGAGCGTGCCC
GCCGCCCCAAGTTCGCTGACATCGTCAGCATCCTGGACAAGCTCATTCGTGCCCCTGACTCCCTCAAGACCCTGGCTGACTTTGACCCCC
GCGTGTCTATCCGGCTCCCCAGCACGAGCGGCTCGGAGGGGGTGCCCTTCCGCACGGTGTCCGAGTGGCTGGAGTCCATCAAGATGCAGC
AGTATACGGAGCACTTCATGGCGGCCGGCTACACTGCCATCGAGAAGGTGGTGCAGATGACCAACGACGACATCAAGAGGATTGGGGTGC
GGCTGCCCGGCCACCAGAAGCGCATCGCCTACAGCCTGCTGGGACTCAAGGACCAGGTGAACACTGTGGGGATCCCCATCTGAGCCTCGA
CAGGGCCTGGAGCCCCATCGGCCAAGAATACTTGAAGAAACAGAGTGGCCTCCCTGCTGTGCCATGCTGGGCCACTGGGGACTTTATTTA
TTTCTAGTTCTTTCCTCCCCCTGCAACTTCCGCTGAGGGGTCTCGGATGACACCCTGGCCTGAACTGAGGAGATGACCAGGGATGCTGGG
CTGGGCCCTCTTTCCCTGCGAGACGCACACAGCTGAGCACTTAGCAGGCACCGCCACGTCCCAGCATCCCTGGAGCAGGAGCCCCGCCAC
AGCCTTCGGACAGACATATGGGATATTCCCAAGCCGACCTTCCCTCCGCCTTCTCCCACATGAGGCCATCTCAGGAGATGGAGGGCTTGG
CCCAGCGCCAAGTAAACAGGGTACCTCAAGCCCCATTTCCTCACACTAAGAGGGCAGACTGTGAACTTGACTGGGTGAGACCCAAAGCGG
TCCCTGTCCCTCTAGTGCCTTCTTTAGACCCTCGGGCCCCATCCTCATCCCTGACTGGCCAAACCCTTGCTTTCCTGGGCCTTTGCAAGA
TGCTTGGTTGTGTTGAGGTTTTTAAATATATATTTTGTACTTTGTGGAGAGAATGTGTGTGTGTGGCAGGGGGCCCCGCCAGGGCTGGGG
ACAGAGGGTGTCAAACATTCGTGAGCTGGGGACTCAGGGACCGGTGCTGCAGGAGTGTCCTGCCCATGCCCCAGTCGGCCCCATCTCTCA
TCCTTTTGGATAAGTTTCTATTCTGTCAGTGTTAAAGATTTTGTTTTGTTGGACATTTTTTTCGAATCTTAATTTATTATTTTTTTTATA

>58376_58376_5_NECAP2-EPHA2_NECAP2_chr1_16775696_ENST00000504551_EPHA2_chr1_16456914_ENST00000358432_length(amino acids)=253AA_BP=102
MEESGYESVLCVKPDVHVYRIPPRATNRGYRGALCSGPGGSVSWHSCGECDGFQQVLRDPHRRWKWWVKQQCEFAKQAQNPDQGPKLDLG
FKEGQTIKLNIAVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLPSTSGSEG

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Fusion Gene PPI Analysis for NECAP2-EPHA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NECAP2-EPHA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NECAP2-EPHA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource