FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:NEDD4-ADAMTSL3 (FusionGDB2 ID:58405)

Fusion Gene Summary for NEDD4-ADAMTSL3

check button Fusion gene summary
Fusion gene informationFusion gene name: NEDD4-ADAMTSL3
Fusion gene ID: 58405
HgeneTgene
Gene symbol

NEDD4

ADAMTSL3

Gene ID

4734

57188

Gene nameNEDD4 E3 ubiquitin protein ligaseADAMTS like 3
SynonymsNEDD4-1|RPF1ADAMTSL-3
Cytomap

15q21.3

15q25.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase NEDD4HECT-type E3 ubiquitin transferase NEDD4cell proliferation-inducing gene 53 proteinneural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligasereceptor-potentiating factor 1ADAMTS-like protein 3a disintegrin-like and metalloprotease domain with thrombospondin type I motifs-like 3punctin-2
Modification date2020031320200320
UniProtAcc

P46934

P82987

Ensembl transtripts involved in fusion geneENST00000435532, ENST00000338963, 
ENST00000506154, ENST00000508075, 
ENST00000508342, 		ENST00000567716, 
ENST00000286744, ENST00000567476, 
Fusion gene scores* DoF score6 X 6 X 3=10813 X 14 X 6=1092
# samples 614
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/1092*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEDD4 [Title/Abstract] AND ADAMTSL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEDD4(56243574)-ADAMTSL3(84373141), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEDD4

GO:0006511

ubiquitin-dependent protein catabolic process

20086093|26263374

HgeneNEDD4

GO:0006622

protein targeting to lysosome

17116753

HgeneNEDD4

GO:0007041

lysosomal transport

18544533

HgeneNEDD4

GO:0010766

negative regulation of sodium ion transport

10642508

HgeneNEDD4

GO:0016567

protein ubiquitination

17996703|18305167|25631046|26280536

HgeneNEDD4

GO:0031623

receptor internalization

18544533

HgeneNEDD4

GO:0032801

receptor catabolic process

18544533

HgeneNEDD4

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneNEDD4

GO:0042391

regulation of membrane potential

17289006

HgeneNEDD4

GO:0042921

glucocorticoid receptor signaling pathway

8649367

HgeneNEDD4

GO:0045732

positive regulation of protein catabolic process

14973438

HgeneNEDD4

GO:0046824

positive regulation of nucleocytoplasmic transport

17218261

HgeneNEDD4

GO:0050847

progesterone receptor signaling pathway

8649367

HgeneNEDD4

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

HgeneNEDD4

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

10642508


check buttonFusion gene breakpoints across NEDD4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ADAMTSL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AO-A03P-01ANEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+


Top

Fusion Gene ORF analysis for NEDD4-ADAMTSL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000435532ENST00000567716NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
In-frameENST00000435532ENST00000286744NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
In-frameENST00000435532ENST00000567476NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-3CDSENST00000338963ENST00000286744NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-3CDSENST00000338963ENST00000567476NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-3CDSENST00000506154ENST00000286744NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-3CDSENST00000506154ENST00000567476NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-3CDSENST00000508075ENST00000286744NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-3CDSENST00000508075ENST00000567476NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-3CDSENST00000508342ENST00000286744NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-3CDSENST00000508342ENST00000567476NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-intronENST00000338963ENST00000567716NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-intronENST00000506154ENST00000567716NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-intronENST00000508075ENST00000567716NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+
intron-intronENST00000508342ENST00000567716NEDD4chr15

56243574

-ADAMTSL3chr15

84373141

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435532NEDD4chr1556243574-ENST00000286744ADAMTSL3chr1584373141+74714281754341805
ENST00000435532NEDD4chr1556243574-ENST00000567476ADAMTSL3chr1584373141+70104281754071796

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435532ENST00000286744NEDD4chr1556243574-ADAMTSL3chr1584373141+0.0002979290.99970204
ENST00000435532ENST00000567476NEDD4chr1556243574-ADAMTSL3chr1584373141+0.0008706670.99912935

Top

Fusion Genomic Features for NEDD4-ADAMTSL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NEDD4chr1556243573-ADAMTSL3chr1584373140+0.0106222440.9893777
NEDD4chr1556243573-ADAMTSL3chr1584373140+0.0106222440.9893777

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for NEDD4-ADAMTSL3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:56243574/chr15:84373141)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEDD4

P46934

ADAMTSL3

P82987

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Specifically ubiquitinates 'Lys-63' in target proteins (PubMed:23644597). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). {ECO:0000269|PubMed:11598133, ECO:0000269|PubMed:17218260, ECO:0000269|PubMed:18305167, ECO:0000269|PubMed:18562292, ECO:0000269|PubMed:20086093, ECO:0000269|PubMed:21399620, ECO:0000269|PubMed:21765395, ECO:0000269|PubMed:23644597, ECO:0000269|PubMed:25631046}.; FUNCTION: (Microbial infection) Involved in the ubiquitination of Ebola virus protein VP40 which plays a role in viral budding. {ECO:0000269|PubMed:12559917}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301185_1279231692.0DomainNote=Ig-like C2-type 2
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301296_1378231692.0DomainNote=Ig-like C2-type 3
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301424_1482231692.0DomainTSP type-1 8
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301483_1545231692.0DomainTSP type-1 9
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301597_1644231692.0DomainTSP type-1 10
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000002867441301655_1691231692.0DomainPLAC
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130418_468231692.0DomainTSP type-1 2
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130478_535231692.0DomainTSP type-1 3
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130564_626231692.0DomainTSP type-1 4
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130703_760231692.0DomainTSP type-1 5
TgeneADAMTSL3chr15:56243574chr15:84373141ENST0000028674413075_124231692.0DomainTSP type-1 1
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130763_818231692.0DomainTSP type-1 6
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130819_881231692.0DomainTSP type-1 7
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000286744130896_992231692.0DomainNote=Ig-like C2-type 1
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301185_1279231683.0DomainNote=Ig-like C2-type 2
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301296_1378231683.0DomainNote=Ig-like C2-type 3
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301424_1482231683.0DomainTSP type-1 8
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301483_1545231683.0DomainTSP type-1 9
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301597_1644231683.0DomainTSP type-1 10
TgeneADAMTSL3chr15:56243574chr15:84373141ENST000005674761301655_1691231683.0DomainPLAC
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130418_468231683.0DomainTSP type-1 2
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130478_535231683.0DomainTSP type-1 3
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130564_626231683.0DomainTSP type-1 4
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130703_760231683.0DomainTSP type-1 5
TgeneADAMTSL3chr15:56243574chr15:84373141ENST0000056747613075_124231683.0DomainTSP type-1 1
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130763_818231683.0DomainTSP type-1 6
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130819_881231683.0DomainTSP type-1 7
TgeneADAMTSL3chr15:56243574chr15:84373141ENST00000567476130896_992231683.0DomainNote=Ig-like C2-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-12268_21501248.0Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-42968_21579901.0Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-12568_21501304.0Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-12568_21501320.0Compositional biasNote=Ser-rich
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122610_64301248.0DomainWW 1
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122767_80001248.0DomainWW 2
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122840_87301248.0DomainWW 3
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122892_92501248.0DomainWW 4
HgeneNEDD4chr15:56243574chr15:84373141ENST00000338963-122984_131801248.0DomainHECT
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429610_64379901.0DomainWW 1
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429767_80079901.0DomainWW 2
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429840_87379901.0DomainWW 3
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429892_92579901.0DomainWW 4
HgeneNEDD4chr15:56243574chr15:84373141ENST00000435532-429984_131879901.0DomainHECT
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125610_64301304.0DomainWW 1
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125767_80001304.0DomainWW 2
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125840_87301304.0DomainWW 3
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125892_92501304.0DomainWW 4
HgeneNEDD4chr15:56243574chr15:84373141ENST00000506154-125984_131801304.0DomainHECT
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125610_64301320.0DomainWW 1
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125767_80001320.0DomainWW 2
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125840_87301320.0DomainWW 3
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125892_92501320.0DomainWW 4
HgeneNEDD4chr15:56243574chr15:84373141ENST00000508342-125984_131801320.0DomainHECT


Top

Fusion Gene Sequence for NEDD4-ADAMTSL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58405_58405_1_NEDD4-ADAMTSL3_NEDD4_chr15_56243574_ENST00000435532_ADAMTSL3_chr15_84373141_ENST00000286744_length(transcript)=7471nt_BP=428nt
GGCCTTTTCCCGCCGCGCTGCCGGGTGCCGCTAGTGCCCGCTCGCCGCGGGAGGCGCTGCTGTCGCTGAGGGAGCGCCTCCTCCTCTTCC
TCCAACTCTTCCCCGCCTCCTCCCGCTTCTCCTCCTCCTCCTCCACAGTTGCCTGCCCTGGGCGGGGGCGAGCGCGTCCGGTTTGCTGGA
AGCGTTCGGAAATGGCAACTTGCGCGGTGGAGGTGTTCGGGCTCCTGGAGGACGAGGAAAATTCACGAATTGTGAGAGTAAGAGTTATAG
CCGGAATAGGCCTTGCCAAGAAGGATATATTGGGAGCTAGTGATCCTTACGTGAGAGTGACGTTATATGACCCAATGAATGGAGTTCTTA
CAAGTGTGCAAACAAAAACCATTAAAAAGAGTTTGAATCCAAAGTGGAATGAAGAAATATTATTCAGAACCACAGCTGAGAAATCTCCTG
GAGCCTATTTCCTTCCCGAGTTTGCACTTTCTCCTCAGGGAAGTTTTCTGGAAGACACAACAGGGGAGCAGTTCCTCACTTATCGCTATG
ATGACCAGACCTCAAGAAACACTCGTTCAGATGAAGACAAAGATGGCAACTGGGATGCTTGGGGCGACTGGAGTGACTGCTCCCGGACCT
GTGGGGGAGGAGCATCATATTCTCTGCGGAGATGTTTGACTGGAAGGAATTGTGAAGGGCAGAACATTCGGTACAAGACATGCAGCAATC
ATGACTGCCCTCCAGATGCAGAAGATTTCAGAGCCCAGCAGTGCTCAGCCTACAATGATGTCCAGTATCAGGGGCATTACTATGAATGGC
TTCCACGATATAATGATCCTGCTGCCCCGTGTGCACTCAAGTGTCATGCACAAGGACAAAACTTGGTGGTGGAGCTGGCACCTAAGGTAC
TGGATGGAACTCGTTGCAACACGGACTCCTTGGACATGTGTATCAGTGGCATCTGTCAGGCAGTGGGCTGCGATCGGCAACTGGGAAGCA
ATGCCAAGGAGGACAACTGTGGAGTCTGTGCCGGCGATGGCTCCACCTGCAGGCTTGTACGGGGACAATCAAAGTCACACGTTTCTCCTG
AAAAAAGAGAAGAAAATGTAATTGCTGTTCCTTTGGGAAGTCGAAGTGTGAGAATTACAGTGAAAGGACCTGCCCACCTCTTTATTGAAT
CAAAAACACTTCAAGGAAGCAAAGGAGAACACAGCTTTAACAGCCCCGGCGTCTTTCTCGTAGAAAACACAACAGTGGAATTTCAGAGGG
GCTCCGAGAGGCAAACTTTTAAGATTCCAGGACCTCTGATGGCTGATTTCATCTTCAAGACCAGGTACACTGCAGCCAAAGACAGCGTGG
TTCAGTTCTTCTTTTACCAGCCCATCAGTCATCAGTGGAGACAAACTGACTTCTTTCCCTGCACTGTGACGTGTGGAGGAGGTTATCAGC
TCAATTCTGCTGAATGTGTGGATATCCGCTTGAAGAGGGTAGTTCCTGACCATTATTGTCACTACTACCCTGAAAATGTAAAACCAAAAC
CAAAACTGAAGGAATGCAGCATGGATCCCTGCCCATCAAGTGATGGATTTAAAGAGATAATGCCCTATGACCACTTCCAACCTCTTCCTC
GCTGGGAACATAATCCTTGGACTGCATGTTCCGTGTCCTGTGGAGGAGGGATTCAGAGACGGAGCTTTGTGTGTGTAGAGGAATCCATGC
ATGGAGAGATATTGCAGGTGGAAGAATGGAAGTGCATGTACGCACCCAAACCCAAGGTTATGCAAACTTGTAATCTGTTTGATTGCCCCA
AGTGGATTGCCATGGAGTGGTCTCAGTGCACAGTGACTTGTGGCCGAGGGTTACGGTACCGGGTTGTTCTGTGTATTAACCACCGCGGAG
AGCATGTTGGGGGCTGCAATCCACAACTGAAGTTACACATCAAAGAAGAATGTGTCATTCCCATCCCGTGTTATAAACCAAAAGAAAAAA
GTCCAGTGGAAGCAAAATTGCCTTGGCTGAAACAAGCACAAGAACTAGAAGAGACCAGAATAGCAACAGAAGAACCAACGTTCATTCCAG
AACCCTGGTCAGCCTGCAGTACCACGTGTGGGCCGGGTGTGCAGGTCCGTGAGGTGAAGTGCCGTGTGCTCCTCACATTCACGCAGACTG
AGACTGAGCTGCCCGAGGAAGAGTGTGAAGGCCCCAAGCTGCCCACCGAACGGCCCTGCCTCCTGGAAGCATGTGATGAGAGCCCGGCCT
CCCGAGAGCTAGACATCCCTCTCCCTGAGGACAGTGAGACGACTTACGACTGGGAGTACGCTGGGTTCACCCCTTGCACAGCAACATGCG
TGGGAGGCCATCAAGAAGCCATAGCAGTGTGCTTACATATCCAGACCCAGCAGACAGTCAATGACAGCTTGTGTGATATGGTCCACCGTC
CTCCAGCCATGAGCCAGGCCTGTAACACAGAGCCCTGTCCCCCCAGGTGGCATGTGGGCTCTTGGGGGCCCTGCTCAGCTACCTGTGGAG
TTGGAATTCAGACCCGAGATGTGTACTGCCTGCACCCAGGGGAGACCCCTGCCCCTCCTGAGGAGTGCCGAGATGAAAAGCCCCATGCTT
TACAAGCATGCAATCAGTTTGACTGCCCTCCTGGCTGGCACATTGAAGAATGGCAGCAGTGTTCCAGGACTTGTGGCGGGGGAACTCAGA
ACAGAAGAGTCACCTGTCGGCAGCTGCTAACGGATGGCAGCTTTTTGAATCTCTCAGATGAATTGTGCCAAGGACCCAAGGCATCGTCTC
ACAAGTCCTGTGCCAGGACAGACTGTCCTCCACATTTAGCTGTGGGAGACTGGTCGAAGTGTTCTGTCAGTTGTGGTGTTGGAATCCAGA
GAAGAAAGCAGGTGTGTCAAAGGCTGGCAGCCAAAGGTCGGCGCATCCCCCTCAGTGAGATGATGTGCAGGGATCTACCAGGGCTCCCTC
TTGTAAGATCTTGCCAGATGCCTGAGTGCAGTAAAATCAAATCAGAGATGAAGACAAAACTTGGTGAGCAGGGTCCGCAGATCCTCAGTG
TCCAGAGAGTCTACATTCAGACAAGGGAAGAGAAGCGTATTAACCTGACCATTGGTAGCAGAGCCTATTTGCTGCCCAACACATCCGTGA
TTATTAAGTGCCCCGTGCGACGATTCCAGAAATCTCTGATCCAGTGGGAGAAGGATGGCCGTTGCCTGCAGAACTCCAAACGGCTTGGCA
TCACCAAGTCAGGCTCACTAAAAATCCATGGTCTTGCTGCCCCCGACATCGGCGTGTACCGGTGCATTGCAGGCTCTGCACAGGAAACAG
TTGTGCTCAAGCTCATTGGTACTGACAACCGGCTCATCGCACGCCCAGCCCTCAGGGAGCCTATGAGGGAATATCCTGGGATGGACCACA
GCGAAGCCAATAGTTTGGGAGTCACATGGCACAAAATGAGGCAAATGTGGAATAACAAAAATGACCTTTATCTGGATGATGACCACATTA
GTAACCAGCCTTTCTTGAGAGCTCTGTTAGGCCACTGCAGCAATTCTGCAGGAAGCACCAACTCCTGGGAGTTGAAGAATAAGCAGTTTG
AAGCAGCAGTTAAACAAGGAGCATATAGCATGGATACAGCCCAGTTTGATGAGCTGATAAGAAACATGAGTCAGCTCATGGAAACCGGAG
AGGTCAGCGATGATCTTGCGTCCCAGCTGATATATCAGCTGGTGGCCGAATTAGCCAAGGCACAGCCAACACACATGCAGTGGCGGGGCA
TCCAGGAAGAGACACCTCCTGCTGCTCAGCTCAGAGGGGAAACAGGGAGTGTGTCCCAAAGCTCGCATGCAAAAAACTCAGGCAAGCTGA
CATTCAAGCCGAAAGGACCTGTTCTCATGAGGCAAAGCCAACCTCCCTCAATTTCATTTAATAAAACAATAAATTCCAGGATTGGAAATA
CAGTATACATTACAAAAAGGACAGAGGTCATCAATATACTGTGTGACCTTATTACCCCCAGTGAGGCCACATATACATGGACCAAGGATG
GAACCTTGTTACAGCCCTCAGTAAAAATAATTTTGGATGGAACTGGGAAGATACAGATACAGAATCCTACAAGGAAAGAACAAGGCATAT
ATGAATGTTCTGTAGCTAATCATCTTGGTTCAGATGTGGAAAGTTCTTCTGTGCTGTATGCAGAGGCACCTGTCATCTTGTCTGTTGAAA
GAAATATCACCAAACCAGAGCACAACCATCTGTCTGTTGTGGTTGGAGGCATCGTGGAGGCAGCCCTTGGAGCAAACGTGACAATCCGAT
GTCCTGTAAAAGGTGTCCCTCAGCCTAATATAACTTGGTTGAAGAGAGGAGGATCTCTGAGTGGCAATGTTTCCTTGCTTTTCAATGGAT
CCCTGTTGTTGCAGAATGTTTCCCTTGAAAATGAAGGAACCTACGTCTGCATAGCCACCAATGCTCTTGGAAAGGCAGTGGCAACATCTG
TACTCCACTTGCTGGAACGAAGATGGCCAGAGAGTAGAATCGTATTTCTGCAAGGACATAAAAAGTACATTCTCCAGGCAACCAACACTA
GAACCAACAGCAATGACCCAACAGGAGAACCCCCGCCTCAAGAGCCTTTTTGGGAGCCTGGTAACTGGTCACATTGTTCTGCCACCTGTG
GTCATTTGGGAGCCCGCATTCAGAGACCCCAGTGTGTGATGGCCAATGGGCAGGAAGTGAGTGAGGCCCTGTGTGATCACCTCCAGAAGC
CACTGGCTGGGTTTGAGCCCTGTAACATCCGGGACTGCCCAGCGAGGTGGTTCACAAGTGTGTGGTCACAGTGCTCTGTGTCTTGCGGTG
AAGGATACCACAGTCGGCAGGTGACGTGCAAGCGGACAAAAGCCAATGGAACTGTGCAGGTGGTGTCTCCAAGAGCATGTGCCCCTAAAG
ACCGGCCTCTGGGAAGAAAACCATGTTTTGGTCATCCATGTGTTCAGTGGGAACCAGGGAACCGGTGTCCTGGACGTTGCATGGGCCGTG
CTGTGAGGATGCAGCAGCGTCACACAGCTTGTCAACACAACAGCTCTGACTCCAACTGTGATGACAGAAAGAGACCCACCTTAAGAAGGA
ACTGCACATCAGGGGCCTGTGATGTGTGTTGGCACACAGGCCCTTGGAAGCCCTGTACAGCAGCCTGTGGCAGGGGTTTCCAGTCTCGGA
AAGTCGACTGTATCCACACAAGGAGTTGCAAACCTGTGGCCAAGAGACACTGTGTACAGAAAAAGAAACCAATTTCCTGGCGGCACTGTC
TTGGGCCCTCCTGTGATAGAGACTGCACAGACACAACTCACTACTGTATGTTTGTAAAACATCTTAATTTGTGTTCTCTAGACCGCTACA
AACAAAGGTGCTGCCAGTCATGTCAAGAGGGATAAACCTTTGGAGGGGTCATGATGCTGCTGTGAAGATAAAAGTAGAATATAAAAGCTC
TTTTCCCCATGTCGCTGATTCAAAAACATGTATTTCTTAAAAGACTAGATTCTATGGATCAAACAGAGGTTGATGCAAAAACACCACTGT
TAAGGTGTAAAGTGAAATTTTCCAATGGTAGTTTTATATTCCAATTTTTTAAAATGATGTATTCAAGGATGAACAAAATACTATAGCATG
CATGCCACTGCACTTGGGACCTCATCATGTCAGTTGAATCGAGAAATCACCAAGATTATGAGTGCATCCTCACGTGCTGCCTCTTTCCTG
TGATATGTAGACTAGCACAGAGTGGTACATCCTAAAAACTTGGGAAACACAGCAACCCATGACTTCCTCTTCTCTCAAGTTGCAGGTTTT
CAACAGTTTTATAAGGTATTTGCATTTTAGAAGCTCTGGCCAGTAGTTGTTAAGATGTTGGCATTAATGGCATTTTCATAGATCCTTGGT
TTAGTCTGTGAAAAAGAAACCATCTCTCTGGATAGGCTGTCACACTGACTGACCTAAGGGTTCATGGAAGCATGGCATCTTGTCCTTGCT
TTTAGAACACCCATGGAAGAAAACACAGAGTAGATATTGCTGTCATTTATACAACTACAGAAATTTATCTATGACCTAATGAGGCATCTC
GGAAGTCAAAGAAGAGGGAAAGTTAACCTTTTCTACTGATTTCGTAGTATATTCAGAGCTTTCTTTTAAGAGCTGTGAATGAAACTTTTT
CTAAGCACTATTCTATTGCACACAAACAGAAAACCAAAGCCTTATTAGACCTAATTTATGCATAAAGTAGTATTCCTGAGAACTTTATTT
TGGAAAATTTATAAGAAAGTAATCCAAATAAGAAACACGATAGTTGAAAATAATTTTTATAGTAAATAATTGTTTTGGGCTGATTTTTCA
GTAAATCCAAAGTGACTTAGGTTAGAAGTTACACTAAGGACCAGGGGTTGGAATCAGAATTTAGTTTAAGATTTGAGGAAAAGGGTAAGG
GTTAGTTTCAGTTTTAGGATTAGAGCTAGAATTGGGTTAGGTGAGAAAGAAAGTTAAGGTTAAGGCTAGAGTTGTCTTTAAGGGTTAGGG
TTAGGACCAGGTTAGGTCAGGGTTGGATTGGGTTTAGATTGGGGCCAGTGCTGGTGTTAGTGATAGTGTCAGGATGGAGGTTAGGTTTGG
AGTAAGCGTTGTTGCTGAAGTGAGTTCAGGCTAGCATTAAATTGTAAGTTCTGAAGCTGATTTGGTTATGGGGTCTTTCCCCTGTATACT
ACCAGTTGTGTCTTTAGATGGCACACAAGTCCAAATAAGTGGTCATACTTCTTTATTCAGGGTCTCAGCTGCCTGTACACCTGCTGCCTA
CATCTTCTTGGCAACAAAGTTACCTGCCACAGGCTCTGCTGAGCCTAGTTCCTGGTCAGTAATAACTGAACAGTGCATTTTGGCTTTGGA
TGTGTCTGTGGACAAGCTTGCTGAGTTTCTCTACCATATTCTGAGCACACGGTCTCTTTTGTTCTAACTTCAGCTTCACTGACACTGGGT
TGAGCACTACTGTATGTGGAGGGTTTGGTGATTGGGAATGGATGGGGGACAGTGAGGAGGACACACCAGCCCATTAGTTGTTAATCATCA
ATCACATCTGATTGTTGAAGGTTATTAAATTAAAAGAAAGATCATTTGTAACATACTCTTTGTATATATTTATTATATGAAAGGTGCAAT
ATTTTATTTTGTACAGTATGTAATAAAGACATGGGACATATATTTTTCTTATTAACAAAATTTCATATTAAATTGCTTCACTTTGTATTT
AAAGTTAAAAGTTACTATTTTTCATTTGCTATTGTACTTTCATTGTTGTCATTCAATTGACATTCCTGTGTACTGTATTTTACTACTGTT
TTTATAACATGAGAGTTAATGTTTCTGTTTCATGATCCTTATGTAATTCAGAAATAAATTTACTTTGATTATTCAGTGGCATCCTTATAA

>58405_58405_1_NEDD4-ADAMTSL3_NEDD4_chr15_56243574_ENST00000435532_ADAMTSL3_chr15_84373141_ENST00000286744_length(amino acids)=1805AA_BP=135
MPGAASARSPREALLSLRERLLLFLQLFPASSRFSSSSSTVACPGRGRARPVCWKRSEMATCAVEVFGLLEDEENSRIVRVRVIAGIGLA
KKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSR
NTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYND
PAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREEN
VIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFY
QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNP
WTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGC
NPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE
EECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQ
ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC
RQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQ
MPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGS
LKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFL
RALLGHCSNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRGIQEETP
PAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWTKDGTLLQP
SVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGV
PQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSND
PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSR
QVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGA
CDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQ

--------------------------------------------------------------
>58405_58405_2_NEDD4-ADAMTSL3_NEDD4_chr15_56243574_ENST00000435532_ADAMTSL3_chr15_84373141_ENST00000567476_length(transcript)=7010nt_BP=428nt
GGCCTTTTCCCGCCGCGCTGCCGGGTGCCGCTAGTGCCCGCTCGCCGCGGGAGGCGCTGCTGTCGCTGAGGGAGCGCCTCCTCCTCTTCC
TCCAACTCTTCCCCGCCTCCTCCCGCTTCTCCTCCTCCTCCTCCACAGTTGCCTGCCCTGGGCGGGGGCGAGCGCGTCCGGTTTGCTGGA
AGCGTTCGGAAATGGCAACTTGCGCGGTGGAGGTGTTCGGGCTCCTGGAGGACGAGGAAAATTCACGAATTGTGAGAGTAAGAGTTATAG
CCGGAATAGGCCTTGCCAAGAAGGATATATTGGGAGCTAGTGATCCTTACGTGAGAGTGACGTTATATGACCCAATGAATGGAGTTCTTA
CAAGTGTGCAAACAAAAACCATTAAAAAGAGTTTGAATCCAAAGTGGAATGAAGAAATATTATTCAGAACCACAGCTGAGAAATCTCCTG
GAGCCTATTTCCTTCCCGAGTTTGCACTTTCTCCTCAGGGAAGTTTTCTGGAAGACACAACAGGGGAGCAGTTCCTCACTTATCGCTATG
ATGACCAGACCTCAAGAAACACTCGTTCAGATGAAGACAAAGATGGCAACTGGGATGCTTGGGGCGACTGGAGTGACTGCTCCCGGACCT
GTGGGGGAGGAGCATCATATTCTCTGCGGAGATGTTTGACTGGAAGGAATTGTGAAGGGCAGAACATTCGGTACAAGACATGCAGCAATC
ATGACTGCCCTCCAGATGCAGAAGATTTCAGAGCCCAGCAGTGCTCAGCCTACAATGATGTCCAGTATCAGGGGCATTACTATGAATGGC
TTCCACGATATAATGATCCTGCTGCCCCGTGTGCACTCAAGTGTCATGCACAAGGACAAAACTTGGTGGTGGAGCTGGCACCTAAGGTAC
TGGATGGAACTCGTTGCAACACGGACTCCTTGGACATGTGTATCAGTGGCATCTGTCAGGCAGTGGGCTGCGATCGGCAACTGGGAAGCA
ATGCCAAGGAGGACAACTGTGGAGTCTGTGCCGGCGATGGCTCCACCTGCAGGCTTGTACGGGGACAATCAAAGTCACACGTTTCTCCTG
AAAAAAGAGAAGAAAATGTAATTGCTGTTCCTTTGGGAAGTCGAAGTGTGAGAATTACAGTGAAAGGACCTGCCCACCTCTTTATTGAAT
CAAAAACACTTCAAGGAAGCAAAGGAGAACACAGCTTTAACAGCCCCGGCGTCTTTCTCGTAGAAAACACAACAGTGGAATTTCAGAGGG
GCTCCGAGAGGCAAACTTTTAAGATTCCAGGACCTCTGATGGCTGATTTCATCTTCAAGACCAGGTACACTGCAGCCAAAGACAGCGTGG
TTCAGTTCTTCTTTTACCAGCCCATCAGTCATCAGTGGAGACAAACTGACTTCTTTCCCTGCACTGTGACGTGTGGAGGAGGTTATCAGC
TCAATTCTGCTGAATGTGTGGATATCCGCTTGAAGAGGGTAGTTCCTGACCATTATTGTCACTACTACCCTGAAAATGTAAAACCAAAAC
CAAAACTGAAGGAATGCAGCATGGATCCCTGCCCATCAAGTGATGGATTTAAAGAGATAATGCCCTATGACCACTTCCAACCTCTTCCTC
GCTGGGAACATAATCCTTGGACTGCATGTTCCGTGTCCTGTGGAGGAGGGATTCAGAGACGGAGCTTTGTGTGTGTAGAGGAATCCATGC
ATGGAGAGATATTGCAGGTGGAAGAATGGAAGTGCATGTACGCACCCAAACCCAAGGTTATGCAAACTTGTAATCTGTTTGATTGCCCCA
AGTGGATTGCCATGGAGTGGTCTCAGTGCACAGTGACTTGTGGCCGAGGGTTACGGTACCGGGTTGTTCTGTGTATTAACCACCGCGGAG
AGCATGTTGGGGGCTGCAATCCACAACTGAAGTTACACATCAAAGAAGAATGTGTCATTCCCATCCCGTGTTATAAACCAAAAGAAAAAA
GTCCAGTGGAAGCAAAATTGCCTTGGCTGAAACAAGCACAAGAACTAGAAGAGACCAGAATAGCAACAGAAGAACCAACGTTCATTCCAG
AACCCTGGTCAGCCTGCAGTACCACGTGTGGGCCGGGTGTGCAGGTCCGTGAGGTGAAGTGCCGTGTGCTCCTCACATTCACGCAGACTG
AGACTGAGCTGCCCGAGGAAGAGTGTGAAGGCCCCAAGCTGCCCACCGAACGGCCCTGCCTCCTGGAAGCATGTGATGAGAGCCCGGCCT
CCCGAGAGCTAGACATCCCTCTCCCTGAGGACAGTGAGACGACTTACGACTGGGAGTACGCTGGGTTCACCCCTTGCACAGCAACATGCG
TGGGAGGCCATCAAGAAGCCATAGCAGTGTGCTTACATATCCAGACCCAGCAGACAGTCAATGACAGCTTGTGTGATATGGTCCACCGTC
CTCCAGCCATGAGCCAGGCCTGTAACACAGAGCCCTGTCCCCCCAGGTGGCATGTGGGCTCTTGGGGGCCCTGCTCAGCTACCTGTGGAG
TTGGAATTCAGACCCGAGATGTGTACTGCCTGCACCCAGGGGAGACCCCTGCCCCTCCTGAGGAGTGCCGAGATGAAAAGCCCCATGCTT
TACAAGCATGCAATCAGTTTGACTGCCCTCCTGGCTGGCACATTGAAGAATGGCAGCAGTGTTCCAGGACTTGTGGCGGGGGAACTCAGA
ACAGAAGAGTCACCTGTCGGCAGCTGCTAACGGATGGCAGCTTTTTGAATCTCTCAGATGAATTGTGCCAAGGACCCAAGGCATCGTCTC
ACAAGTCCTGTGCCAGGACAGACTGTCCTCCACATTTAGCTGTGGGAGACTGGTCGAAGTGTTCTGTCAGTTGTGGTGTTGGAATCCAGA
GAAGAAAGCAGGTGTGTCAAAGGCTGGCAGCCAAAGGTCGGCGCATCCCCCTCAGTGAGATGATGTGCAGGGATCTACCAGGGCTCCCTC
TTGTAAGATCTTGCCAGATGCCTGAGTGCAGTAAAATCAAATCAGAGATGAAGACAAAACTTGGTGAGCAGGGTCCGCAGATCCTCAGTG
TCCAGAGAGTCTACATTCAGACAAGGGAAGAGAAGCGTATTAACCTGACCATTGGTAGCAGAGCCTATTTGCTGCCCAACACATCCGTGA
TTATTAAGTGCCCCGTGCGACGATTCCAGAAATCTCTGATCCAGTGGGAGAAGGATGGCCGTTGCCTGCAGAACTCCAAACGGCTTGGCA
TCACCAAGTCAGGCTCACTAAAAATCCATGGTCTTGCTGCCCCCGACATCGGCGTGTACCGGTGCATTGCAGGCTCTGCACAGGAAACAG
TTGTGCTCAAGCTCATTGGTACTGACAACCGGCTCATCGCACGCCCAGCCCTCAGGGAGCCTATGAGGGAATATCCTGGGATGGACCACA
GCGAAGCCAATAGTTTGGGAGTCACATGGCACAAAATGAGGCAAATGTGGAATAACAAAAATGACCTTTATCTGGATGATGACCACATTA
GTAACCAGCCTTTCTTGAGAGCTCTGTTAGGCCACTGCAGCAATTCTGCAGGAAGCACCAACTCCTGGGAGTTGAAGAATAAGCAGTTTG
AAGCAGCAGTTAAACAAGGAGCATATAGCATGGATACAGCCCAGTTTGATGAGCTGATAAGAAACATGAGTCAGCTCATGGAAACCGGAG
AGGTCAGCGATGATCTTGCGTCCCAGCTGATATATCAGCTGGTGGCCGAATTAGCCAAGGCACAGCCAACACACATGCAGTGGCGGGGCA
TCCAGGAAGAGACACCTCCTGCTGCTCAGCTCAGAGGGGAAACAGGGAGTGTGTCCCAAAGCTCGCATGCAAAAAACTCAGGCAAGCTGA
CATTCAAGCCGAAAGGACCTGTTCTCATGAGGCAAAGCCAACCTCCCTCAATTTCATTTAATAAAACAATAAATTCCAGGATTGGAAATA
CAGTATACATTACAAAAAGGACAGAGGTCATCAATATACTGTGTGACCTTATTACCCCCAGTGAGGCCACATATACATGGACCAAGGATG
GAACCTTGTTACAGCCCTCAGTAAAAATAATTTTGGATGGAACTGGGAAGATACAGATACAGAATCCTACAAGGAAAGAACAAGGCATAT
ATGAATGTTCTGTAGCTAATCATCTTGGTTCAGATGTGGAAAGTTCTTCTGTGCTGTATGCAGAGGCACCTGTCATCTTGTCTGTTGAAA
GAAATATCACCAAACCAGAGCACAACCATCTGTCTGTTGTGGTTGGAGGCATCGTGGAGGCAGCCCTTGGAGCAAACGTGACAATCCGAT
GTCCTGTAAAAGGTGTCCCTCAGCCTAATATAACTTGGTTGAAGAGAGGAGGATCTCTGAGTGGCAATGTTTCCTTGCTTTTCAATGGAT
CCCTGTTGTTGCAGAATGTTTCCCTTGAAAATGAAGGAACCTACGTCTGCATAGCCACCAATGCTCTTGGAAAGGCAGTGGCAACATCTG
TACTCCACTTGCTGGAACGAAGATGGCCAGAGAGTAGAATCGTATTTCTGCAAGGACATAAAAAGTACATTCTCCAGGCAACCAACACTA
GAACCAACAGCAATGACCCAACAGGAGAACCCCCGCCTCAAGAGCCTTTTTGGGAGCCTGGTAACTGGTCACATTGTTCTGCCACCTGTG
GTCATTTGGGAGCCCGCATTCAGAGACCCCAGTGTGTGATGGCCAATGGGCAGGAAGTGAGTGAGGCCCTGTGTGATCACCTCCAGAAGC
CACTGGCTGGGTTTGAGCCCTGTAACATCCGGGACTGCCCAGCGAGGTGGTTCACAAGTGTGTGGTCACAGTGCTCTGTGTCTTGCGGTG
AAGGATACCACAGTCGGCAGGTGACGTGCAAGCGGACAAAAGCCAATGGAACTGTGCAGGTGGTGTCTCCAAGAGCATGTGCCCCTAAAG
ACCGGCCTCTGGGAAGAAAACCATGTTTTGGTCATCCATGTGTTCAGTGGGAACCAGGGAACCGGTGTCCTGGACGTTGCATGGGCCGTG
CTGTGAGGATGCAGCAGCGTCACACAGCTTGTCAACACAACAGCTCTGACTCCAACTGTGATGACAGAAAGAGACCCACCTTAAGAAGGA
ACTGCACATCAGGGGCCTGTGATGTGTGTTGGCACACAGGCCCTTGGAAGCCCTGTACAGCAGCCTGTGGCAGGGGTTTCCAGTCTCGGA
AAGTCGACTGTATCCACACAAGGAGTTGCAAACCTGTGGCCAAGAGACACTGTGTACAGAAAAAGAAACCAATTTCCTGGCGGCACTGTC
TTGGGCCCTCCTGTGATAGTACGTACACCTCCCAGACCGCTACAAACAAAGGTGCTGCCAGTCATGTCAAGAGGGATAAACCTTTGGAGG
GGTCATGATGCTGCTGTGAAGATAAAAGTAGAATATAAAAGCTCTTTTCCCCATGTCGCTGATTCAAAAACATGTATTTCTTAAAAGACT
AGATTCTATGGATCAAACAGAGGTTGATGCAAAAACACCACTGTTAAGGTGTAAAGTGAAATTTTCCAATGGTAGTTTTATATTCCAATT
TTTTAAAATGATGTATTCAAGGATGAACAAAATACTATAGCATGCATGCCACTGCACTTGGGACCTCATCATGTCAGTTGAATCGAGAAA
TCACCAAGATTATGAGTGCATCCTCACGTGCTGCCTCTTTCCTGTGATATGTAGACTAGCACAGAGTGGTACATCCTAAAAACTTGGGAA
ACACAGCAACCCATGACTTCCTCTTCTCTCAAGTTGCAGGTTTTCAACAGTTTTATAAGGTATTTGCATTTTAGAAGCTCTGGCCAGTAG
TTGTTAAGATGTTGGCATTAATGGCATTTTCATAGATCCTTGGTTTAGTCTGTGAAAAAGAAACCATCTCTCTGGATAGGCTGTCACACT
GACTGACCTAAGGGTTCATGGAAGCATGGCATCTTGTCCTTGCTTTTAGAACACCCATGGAAGAAAACACAGAGTAGATATTGCTGTCAT
TTATACAACTACAGAAATTTATCTATGACCTAATGAGGCATCTCGGAAGTCAAAGAAGAGGGAAAGTTAACCTTTTCTACTGATTTCGTA
GTATATTCAGAGCTTTCTTTTAAGAGCTGTGAATGAAACTTTTTCTAAGCACTATTCTATTGCACACAAACAGAAAACCAAAGCCTTATT
AGACCTAATTTATGCATAAAGTAGTATTCCTGAGAACTTTATTTTGGAAAATTTATAAGAAAGTAATCCAAATAAGAAACACGATAGTTG
AAAATAATTTTTATAGTAAATAATTGTTTTGGGCTGATTTTTCAGTAAATCCAAAGTGACTTAGGTTAGAAGTTACACTAAGGACCAGGG
GTTGGAATCAGAATTTAGTTTAAGATTTGAGGAAAAGGGTAAGGGTTAGTTTCAGTTTTAGGATTAGAGCTAGAATTGGGTTAGGTGAGA
AAGAAAGTTAAGGTTAAGGCTAGAGTTGTCTTTAAGGGTTAGGGTTAGGACCAGGTTAGGTCAGGGTTGGATTGGGTTTAGATTGGGGCC
AGTGCTGGTGTTAGTGATAGTGTCAGGATGGAGGTTAGGTTTGGAGTAAGCGTTGTTGCTGAAGTGAGTTCAGGCTAGCATTAAATTGTA
AGTTCTGAAGCTGATTTGGTTATGGGGTCTTTCCCCTGTATACTACCAGTTGTGTCTTTAGATGGCACACAAGTCCAAATAAGTGGTCAT
ACTTCTTTATTCAGGGTCTCAGCTGCCTGTACACCTGCTGCCTACATCTTCTTGGCAACAAAGTTACCTGCCACAGGCTCTGCTGAGCCT
AGTTCCTGGTCAGTAATAACTGAACAGTGCATTTTGGCTTTGGATGTGTCTGTGGACAAGCTTGCTGAGTTTCTCTACCATATTCTGAGC

>58405_58405_2_NEDD4-ADAMTSL3_NEDD4_chr15_56243574_ENST00000435532_ADAMTSL3_chr15_84373141_ENST00000567476_length(amino acids)=1796AA_BP=135
MPGAASARSPREALLSLRERLLLFLQLFPASSRFSSSSSTVACPGRGRARPVCWKRSEMATCAVEVFGLLEDEENSRIVRVRVIAGIGLA
KKDILGASDPYVRVTLYDPMNGVLTSVQTKTIKKSLNPKWNEEILFRTTAEKSPGAYFLPEFALSPQGSFLEDTTGEQFLTYRYDDQTSR
NTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAYNDVQYQGHYYEWLPRYND
PAAPCALKCHAQGQNLVVELAPKVLDGTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREEN
VIAVPLGSRSVRITVKGPAHLFIESKTLQGSKGEHSFNSPGVFLVENTTVEFQRGSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFFFY
QPISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNP
WTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGC
NPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPE
EECEGPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQ
ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTC
RQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQ
MPECSKIKSEMKTKLGEQGPQILSVQRVYIQTREEKRINLTIGSRAYLLPNTSVIIKCPVRRFQKSLIQWEKDGRCLQNSKRLGITKSGS
LKIHGLAAPDIGVYRCIAGSAQETVVLKLIGTDNRLIARPALREPMREYPGMDHSEANSLGVTWHKMRQMWNNKNDLYLDDDHISNQPFL
RALLGHCSNSAGSTNSWELKNKQFEAAVKQGAYSMDTAQFDELIRNMSQLMETGEVSDDLASQLIYQLVAELAKAQPTHMQWRGIQEETP
PAAQLRGETGSVSQSSHAKNSGKLTFKPKGPVLMRQSQPPSISFNKTINSRIGNTVYITKRTEVINILCDLITPSEATYTWTKDGTLLQP
SVKIILDGTGKIQIQNPTRKEQGIYECSVANHLGSDVESSSVLYAEAPVILSVERNITKPEHNHLSVVVGGIVEAALGANVTIRCPVKGV
PQPNITWLKRGGSLSGNVSLLFNGSLLLQNVSLENEGTYVCIATNALGKAVATSVLHLLERRWPESRIVFLQGHKKYILQATNTRTNSND
PTGEPPPQEPFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSR
QVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNRCPGRCMGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NEDD4-ADAMTSL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for NEDD4-ADAMTSL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for NEDD4-ADAMTSL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource