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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NEDD8-NRL (FusionGDB2 ID:58448) |
Fusion Gene Summary for NEDD8-NRL |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NEDD8-NRL | Fusion gene ID: 58448 | Hgene | Tgene | Gene symbol | NEDD8 | NRL | Gene ID | 4738 | 4901 |
| Gene name | NEDD8 ubiquitin like modifier | neural retina leucine zipper | |
| Synonyms | NEDD-8 | D14S46E|NRL-MAF|RP27 | |
| Cytomap | 14q12 | 14q11.2-q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | NEDD8neddylinneural precursor cell expressed, developmentally down-regulated 8ubiquitin-like protein Nedd8 | neural retina-specific leucine zipper proteinneural retinal-specific leucine zipper | |
| Modification date | 20200327 | 20200313 | |
| UniProtAcc | NUB1 | P54845 | |
| Ensembl transtripts involved in fusion gene | ENST00000250495, ENST00000524927, ENST00000533242, | ENST00000396995, ENST00000560550, ENST00000396997, ENST00000397002, ENST00000561028, | |
| Fusion gene scores | * DoF score | 1 X 2 X 1=2 | 4 X 5 X 4=80 |
| # samples | 2 | 6 | |
| ** MAII score | log2(2/2*10)=3.32192809488736 | log2(6/80*10)=-0.415037499278844 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NEDD8 [Title/Abstract] AND NRL [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NEDD8(24701456)-NRL(24550777), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | NEDD8-NRL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. NEDD8-NRL seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. NEDD8-NRL seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NEDD8 | GO:0045116 | protein neddylation | 10500095 |
| Tgene | NRL | GO:0045944 | positive regulation of transcription by RNA polymerase II | 8552602 |
| Fusion gene breakpoints across NEDD8 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across NRL (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | ESCA | TCGA-LN-A49L-01A | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| ChimerDB4 | ESCA | TCGA-LN-A49L | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| ChimerDB4 | ESCA | TCGA-LN-A49L | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
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Fusion Gene ORF analysis for NEDD8-NRL |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000250495 | ENST00000396995 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5CDS-5UTR | ENST00000250495 | ENST00000560550 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5CDS-5UTR | ENST00000524927 | ENST00000396995 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5CDS-5UTR | ENST00000524927 | ENST00000560550 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000396997 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000396997 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000397002 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000397002 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000561028 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-3CDS | ENST00000533242 | ENST00000561028 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| 5UTR-5UTR | ENST00000533242 | ENST00000396995 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-5UTR | ENST00000533242 | ENST00000396995 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| 5UTR-5UTR | ENST00000533242 | ENST00000560550 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| 5UTR-5UTR | ENST00000533242 | ENST00000560550 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| Frame-shift | ENST00000250495 | ENST00000396997 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| Frame-shift | ENST00000250495 | ENST00000561028 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| Frame-shift | ENST00000524927 | ENST00000396997 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| Frame-shift | ENST00000524927 | ENST00000561028 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| In-frame | ENST00000250495 | ENST00000397002 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| In-frame | ENST00000524927 | ENST00000397002 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - |
| intron-3CDS | ENST00000250495 | ENST00000396997 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-3CDS | ENST00000250495 | ENST00000397002 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-3CDS | ENST00000250495 | ENST00000561028 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-3CDS | ENST00000524927 | ENST00000396997 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-3CDS | ENST00000524927 | ENST00000397002 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-3CDS | ENST00000524927 | ENST00000561028 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-5UTR | ENST00000250495 | ENST00000396995 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-5UTR | ENST00000250495 | ENST00000560550 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-5UTR | ENST00000524927 | ENST00000396995 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| intron-5UTR | ENST00000524927 | ENST00000560550 | NEDD8 | chr14 | 24700858 | - | NRL | chr14 | 24550777 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000250495 | NEDD8 | chr14 | 24701456 | - | ENST00000397002 | NRL | chr14 | 24550777 | - | 1667 | 205 | 592 | 194 | 132 |
| ENST00000524927 | NEDD8 | chr14 | 24701456 | - | ENST00000397002 | NRL | chr14 | 24550777 | - | 1567 | 105 | 492 | 94 | 132 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000250495 | ENST00000397002 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - | 0.10948773 | 0.8905123 |
| ENST00000524927 | ENST00000397002 | NEDD8 | chr14 | 24701456 | - | NRL | chr14 | 24550777 | - | 0.110420465 | 0.88957953 |
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Fusion Genomic Features for NEDD8-NRL |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for NEDD8-NRL |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:24701456/chr14:24550777) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NEDD8 | NRL |
| 615 | FUNCTION: Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B (PubMed:21981118). Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3 (PubMed:17335001). Binds in a sequence-specific manner to the rhodopsin promoter (PubMed:17335001). {ECO:0000269|PubMed:17335001, ECO:0000269|PubMed:21981118}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000396997 | 2 | 4 | 159_222 | 127 | 238.0 | Domain | bZIP | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000397002 | 1 | 3 | 159_222 | 127 | 238.0 | Domain | bZIP | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000561028 | 1 | 3 | 159_222 | 127 | 238.0 | Domain | bZIP | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000396997 | 2 | 4 | 159_185 | 127 | 238.0 | Region | Basic motif | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000396997 | 2 | 4 | 187_208 | 127 | 238.0 | Region | Leucine-zipper | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000397002 | 1 | 3 | 159_185 | 127 | 238.0 | Region | Basic motif | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000397002 | 1 | 3 | 187_208 | 127 | 238.0 | Region | Leucine-zipper | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000561028 | 1 | 3 | 159_185 | 127 | 238.0 | Region | Basic motif | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000561028 | 1 | 3 | 187_208 | 127 | 238.0 | Region | Leucine-zipper |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000396997 | 2 | 4 | 30_93 | 127 | 238.0 | Region | Minimal transactivation domain (MTD) | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000397002 | 1 | 3 | 30_93 | 127 | 238.0 | Region | Minimal transactivation domain (MTD) | |
| Tgene | NRL | chr14:24701456 | chr14:24550777 | ENST00000561028 | 1 | 3 | 30_93 | 127 | 238.0 | Region | Minimal transactivation domain (MTD) |
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Fusion Gene Sequence for NEDD8-NRL |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >58448_58448_1_NEDD8-NRL_NEDD8_chr14_24701456_ENST00000250495_NRL_chr14_24550777_ENST00000397002_length(transcript)=1667nt_BP=205nt TGAACCGAAACGCGGGAGCAACCCTGAGCCTTTCCGGAACCCAGTGGGGGGGGGGGGGGGGGTGGAGCCAGACAGTGACCCGGAAGTAGA AGTGGCCCTTGCAGGCAAGAGTGCTGGAGGGCGGCAGCGGCGACCGGAGCGGTAGGAGCAGCAATTTATCCGTGTGCAGCCCCAAACTGG AAAGAAGATGCTAATTAAAGTGAAGCTGGCAGAGCGGTTTTCCGACGCGGCGCTGGTCTCGATGTCTGTGCGGGAGCTAAACCGGCAGCT GCGGGGCTGCGGGCGCGACGAGGCGCTGCGGCTGAAGCAGAGGCGCCGCACGCTGAAGAACCGCGGCTACGCGCAGGCCTGTCGCTCCAA GCGGCTGCAGCAGCGGCGCGGGCTGGAGGCCGAGCGCGCCCGCCTGGCCGCCCAGCTGGACGCGCTGCGGGCCGAGGTGGCCCGCCTGGC CCGGGAGCGCGATCTCTACAAGGCTCGCTGTGACCGGCTAACCTCGAGCGGCCCCGGGTCCGGGGACCCCTCCCACCTCTTCCTCTGAGC CGTTCAGAGCACCTTGTGGTGTAGTGGGGGCTGGGTGGGGTGGCTCCGCCCAGGAGGCGGCTGCACGGTTCTCTGCATCGTTACCAGAGC GCCTTCTGGTCCTAGCCACGCCCTGTATGACCGCGCAAATATCCCCAAAGCTTTTGGGTCCTCAAGTCATGCCCGAATTTAGATGCTGGT CATTTTCTGGAGAGGGGTCCCCTCCCCTTACGAACACAGAAACCCAGCCCACATGACTAGCACGCTGAGCTCTGCAGGGACCAGTGCCAG GCACTGGGGGGTGGAAGTGTGGTGACACAGTGAATGGGAGGTGGAGGAGGGTTGCAGCTCCCACCTCAGTTTAGTTTTTAATTCAGGGTT TTCAACCTGTAACACATTAAAGCTGTAATTAGCAATGAGGCTGTATTTTCATTCTGAAGCTTGTAACCTCCCCATTTTAGCACTACAGAA TTTTCAAGATTTCAATATCCAACAACTAGATAGATTAGGACCTCTATCCGAGATGCTTTTTCCCTGCCCAACCCTGTGGCCTTCAGGGCT CAGAGCAGCAAAGGCCTGAAGAGTGAGCTCTGGGGGTTGTTGGTGTGGGTTGGGAGAGAGCTGTGTGCAGAAGTCTGGAAACCTGGGTCC TAGTCCCAGCTCTTCCATGGGATCCCCCTGTCACCCTGAGCAAATCAGTTGCTTCCTGGACTTGTGTTACTTCATCTAATTCTCATGTGG ATTGGACGACTTCTGCTCCCTTTCCAGTTCTGGCATCTCCCCAGTATGGAAGTCCCGGTGGTCTCCCCAAGAAGTCCCCAAGACAATCTC GCCAAAGGCACCTCCTATCCTGCTGCAGTTTCCCAGCTGCAGCCTAGGCAGGGGATGCACAGCCCAGGCGAGGAAGCCTGGCTTCTCTGT GAGCACATACGTGGGTCCTCGGCAGCTCCCTCCAGGCTGTCTGGGCCTCCAGACCTGCACAGGGTGCTCCTGCCACCTCCCACCTCTCTG AGGGCTGAGGTGAGACTTCTCCTGGGATGACAATTTGCTGAGAGAGTGCAGCTTTTGTGAATTAAACTTGAAGTCCAGGCAGAATTCTAA >58448_58448_1_NEDD8-NRL_NEDD8_chr14_24701456_ENST00000250495_NRL_chr14_24550777_ENST00000397002_length(amino acids)=132AA_BP=1 MGGATPPSPHYTTRCSERLRGRGGRGPRTRGRSRLAGHSEPCRDRAPGPGGPPRPAARPAGRPGGRARPPARAAAAAAWSDRPARSRGSS -------------------------------------------------------------- >58448_58448_2_NEDD8-NRL_NEDD8_chr14_24701456_ENST00000524927_NRL_chr14_24550777_ENST00000397002_length(transcript)=1567nt_BP=105nt GCAGGCAAGAGTGCTGGAGGGCGGCAGCGGCGACCGGAGCGGTAGGAGCAGCAATTTATCCGTGTGCAGCCCCAAACTGGAAAGAAGATG CTAATTAAAGTGAAGCTGGCAGAGCGGTTTTCCGACGCGGCGCTGGTCTCGATGTCTGTGCGGGAGCTAAACCGGCAGCTGCGGGGCTGC GGGCGCGACGAGGCGCTGCGGCTGAAGCAGAGGCGCCGCACGCTGAAGAACCGCGGCTACGCGCAGGCCTGTCGCTCCAAGCGGCTGCAG CAGCGGCGCGGGCTGGAGGCCGAGCGCGCCCGCCTGGCCGCCCAGCTGGACGCGCTGCGGGCCGAGGTGGCCCGCCTGGCCCGGGAGCGC GATCTCTACAAGGCTCGCTGTGACCGGCTAACCTCGAGCGGCCCCGGGTCCGGGGACCCCTCCCACCTCTTCCTCTGAGCCGTTCAGAGC ACCTTGTGGTGTAGTGGGGGCTGGGTGGGGTGGCTCCGCCCAGGAGGCGGCTGCACGGTTCTCTGCATCGTTACCAGAGCGCCTTCTGGT CCTAGCCACGCCCTGTATGACCGCGCAAATATCCCCAAAGCTTTTGGGTCCTCAAGTCATGCCCGAATTTAGATGCTGGTCATTTTCTGG AGAGGGGTCCCCTCCCCTTACGAACACAGAAACCCAGCCCACATGACTAGCACGCTGAGCTCTGCAGGGACCAGTGCCAGGCACTGGGGG GTGGAAGTGTGGTGACACAGTGAATGGGAGGTGGAGGAGGGTTGCAGCTCCCACCTCAGTTTAGTTTTTAATTCAGGGTTTTCAACCTGT AACACATTAAAGCTGTAATTAGCAATGAGGCTGTATTTTCATTCTGAAGCTTGTAACCTCCCCATTTTAGCACTACAGAATTTTCAAGAT TTCAATATCCAACAACTAGATAGATTAGGACCTCTATCCGAGATGCTTTTTCCCTGCCCAACCCTGTGGCCTTCAGGGCTCAGAGCAGCA AAGGCCTGAAGAGTGAGCTCTGGGGGTTGTTGGTGTGGGTTGGGAGAGAGCTGTGTGCAGAAGTCTGGAAACCTGGGTCCTAGTCCCAGC TCTTCCATGGGATCCCCCTGTCACCCTGAGCAAATCAGTTGCTTCCTGGACTTGTGTTACTTCATCTAATTCTCATGTGGATTGGACGAC TTCTGCTCCCTTTCCAGTTCTGGCATCTCCCCAGTATGGAAGTCCCGGTGGTCTCCCCAAGAAGTCCCCAAGACAATCTCGCCAAAGGCA CCTCCTATCCTGCTGCAGTTTCCCAGCTGCAGCCTAGGCAGGGGATGCACAGCCCAGGCGAGGAAGCCTGGCTTCTCTGTGAGCACATAC GTGGGTCCTCGGCAGCTCCCTCCAGGCTGTCTGGGCCTCCAGACCTGCACAGGGTGCTCCTGCCACCTCCCACCTCTCTGAGGGCTGAGG TGAGACTTCTCCTGGGATGACAATTTGCTGAGAGAGTGCAGCTTTTGTGAATTAAACTTGAAGTCCAGGCAGAATTCTAATGCAATAAGC >58448_58448_2_NEDD8-NRL_NEDD8_chr14_24701456_ENST00000524927_NRL_chr14_24550777_ENST00000397002_length(amino acids)=132AA_BP=1 MGGATPPSPHYTTRCSERLRGRGGRGPRTRGRSRLAGHSEPCRDRAPGPGGPPRPAARPAGRPGGRARPPARAAAAAAWSDRPARSRGSS -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for NEDD8-NRL |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | NEDD8 | chr14:24701456 | chr14:24550777 | ENST00000250495 | - | 1 | 4 | 70_72 | 6.0 | 82.0 | UBE1C |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for NEDD8-NRL |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for NEDD8-NRL |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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