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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NEIL2-TTC7B (FusionGDB2 ID:58491)

Fusion Gene Summary for NEIL2-TTC7B

Fusion gene summary

Fusion gene information	Fusion gene name: NEIL2-TTC7B
	Fusion gene ID: 58491
		Hgene	Tgene
	Gene symbol	NEIL2	TTC7B
	Gene ID	252969	145567
	Gene name	nei like DNA glycosylase 2	tetratricopeptide repeat domain 7B
	Synonyms	NEH2\|NEI2	TTC7L1\|c14_5685
	Cytomap	8p23.1	14q32.11
	Type of gene	protein-coding	protein-coding
	Description	endonuclease 8-like 2DNA glycosylase/AP lyase Neil2DNA-(apurinic or apyrimidinic site) lyase Neil2nei endonuclease VIII-like 2nei homolog 2nei-like protein 2	tetratricopeptide repeat protein 7BTPR repeat protein 7-like-1TPR repeat protein 7Btetratricopeptide repeat domain 7 like 1tetratricopeptide repeat protein 7-like-1
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000284503, ENST00000403422, ENST00000436750, ENST00000455213, ENST00000528323,	ENST00000554654, ENST00000328459, ENST00000357056,
Fusion gene scores	* DoF score	2 X 2 X 2=8	11 X 11 X 5=605
	# samples	2	12
	** MAII score	log2(2/8*10)=1.32192809488736	log2(12/605*10)=-2.33390073655344 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NEIL2 [Title/Abstract] AND TTC7B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NEIL2(11637459)-TTC7B(91146879), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TTC7B	GO:0046854	phosphatidylinositol phosphorylation	23229899\|26571211
Tgene	TTC7B	GO:0072659	protein localization to plasma membrane	23229899\|26571211

Fusion gene breakpoints across NEIL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TTC7B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-GC-A4ZW-01A	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-

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Fusion Gene ORF analysis for NEIL2-TTC7B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000284503	ENST00000554654	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
5CDS-intron	ENST00000403422	ENST00000554654	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
5CDS-intron	ENST00000436750	ENST00000554654	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
5CDS-intron	ENST00000455213	ENST00000554654	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
In-frame	ENST00000284503	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
In-frame	ENST00000284503	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
In-frame	ENST00000403422	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
In-frame	ENST00000403422	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
In-frame	ENST00000436750	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
In-frame	ENST00000436750	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
In-frame	ENST00000455213	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
In-frame	ENST00000455213	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
intron-3CDS	ENST00000528323	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
intron-3CDS	ENST00000528323	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-
intron-intron	ENST00000528323	ENST00000554654	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000436750	NEIL2	chr8	11637459	-	ENST00000357056	TTC7B	chr14	91146879	-	3058	646	155	2278	707
ENST00000436750	NEIL2	chr8	11637459	-	ENST00000328459	TTC7B	chr14	91146879	-	3007	646	155	2227	690
ENST00000455213	NEIL2	chr8	11637459	-	ENST00000357056	TTC7B	chr14	91146879	-	3160	748	257	2380	707
ENST00000455213	NEIL2	chr8	11637459	-	ENST00000328459	TTC7B	chr14	91146879	-	3109	748	257	2329	690
ENST00000403422	NEIL2	chr8	11637459	-	ENST00000357056	TTC7B	chr14	91146879	-	2848	436	17	2068	683
ENST00000403422	NEIL2	chr8	11637459	-	ENST00000328459	TTC7B	chr14	91146879	-	2797	436	17	2017	666
ENST00000284503	NEIL2	chr8	11637459	-	ENST00000357056	TTC7B	chr14	91146879	-	3502	1090	599	2722	707
ENST00000284503	NEIL2	chr8	11637459	-	ENST00000328459	TTC7B	chr14	91146879	-	3451	1090	599	2671	690

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000436750	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-	0.011634266	0.98836577
ENST00000436750	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-	0.01125335	0.9887467
ENST00000455213	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-	0.0107163	0.9892837
ENST00000455213	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-	0.010740952	0.98925906
ENST00000403422	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-	0.008851633	0.99114835
ENST00000403422	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-	0.008432612	0.99156743
ENST00000284503	ENST00000357056	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-	0.01192121	0.9880788
ENST00000284503	ENST00000328459	NEIL2	chr8	11637459	-	TTC7B	chr14	91146879	-	0.011852357	0.9881477

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Fusion Genomic Features for NEIL2-TTC7B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEIL2-TTC7B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:11637459/chr14:91146879)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

329_333

316

844.0

Compositional bias

Note=Poly-Leu

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

329_333

316

861.0

Compositional bias

Note=Poly-Leu

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

363_396

316

844.0

Repeat

Note=TPR 3

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

397_430

316

844.0

Repeat

Note=TPR 4

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

479_514

316

844.0

Repeat

Note=TPR 5

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

516_548

316

844.0

Repeat

Note=TPR 6

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

549_582

316

844.0

Repeat

Note=TPR 7

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

696_729

316

844.0

Repeat

Note=TPR 8

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

730_763

316

844.0

Repeat

Note=TPR 9

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

765_797

316

844.0

Repeat

Note=TPR 10

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

798_831

316

844.0

Repeat

Note=TPR 11

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

363_396

316

861.0

Repeat

Note=TPR 3

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

397_430

316

861.0

Repeat

Note=TPR 4

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

479_514

316

861.0

Repeat

Note=TPR 5

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

516_548

316

861.0

Repeat

Note=TPR 6

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

549_582

316

861.0

Repeat

Note=TPR 7

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

696_729

316

861.0

Repeat

Note=TPR 8

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

730_763

316

861.0

Repeat

Note=TPR 9

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

765_797

316

861.0

Repeat

Note=TPR 10

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

798_831

316

861.0

Repeat

Note=TPR 11

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NEIL2

chr8:11637459

chr14:91146879

ENST00000284503

284_320

163

333.0

Zinc finger

FPG-type

Hgene

NEIL2

chr8:11637459

chr14:91146879

ENST00000403422

284_320

102

272.0

Zinc finger

FPG-type

Hgene

NEIL2

chr8:11637459

chr14:91146879

ENST00000436750

284_320

163

333.0

Zinc finger

FPG-type

Hgene

NEIL2

chr8:11637459

chr14:91146879

ENST00000455213

284_320

163

333.0

Zinc finger

FPG-type

Hgene

NEIL2

chr8:11637459

chr14:91146879

ENST00000528323

284_320

217.0

Zinc finger

FPG-type

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

219_252

316

844.0

Repeat

Note=TPR 2

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000328459

97_131

316

844.0

Repeat

Note=TPR 1

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

219_252

316

861.0

Repeat

Note=TPR 2

Tgene

TTC7B

chr8:11637459

chr14:91146879

ENST00000357056

97_131

316

861.0

Repeat

Note=TPR 1

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Fusion Gene Sequence for NEIL2-TTC7B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>58491_58491_1_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000284503_TTC7B_chr14_91146879_ENST00000328459_length(transcript)=3451nt_BP=1090nt
GCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGTGAGTGCAGCCGCCCGCCCTCCGGTAGATCTGCGGC
CTGGCGGAGAAGTCGGGAGGGGACAGGAAGGGAGGGCGGGCCCCGGGCCCTCCTCCGTCTCAGCCGCCTGCGGAGGTGCTGCCCACGCCT
GGAGGCCCCCACTGACCCTCAGACCCGCGTCTGCGCCCCTCTCCCCGCACCCCGAGGCAGAGTTGGGAAAGCAGTGGTCTTAGACCCCCC
ACCTCGGGCACTCGGAAGAGAACGGCGGAGACAACCCCTCCTCTTCCCTGGCTGGCGCAGCGCCAGCCTCGAGCTCCTCGGTAGCCCCCG
GGCAGGGAGGGCCGGAGGGTGGGCGCGGCATCTTCAGCGACTCTTCGAAGTCCCTTCCGCGTCTCATCTTTCAAGGCTGTTGCAGAGGCG
GCTTGCTTCCCACCTGTCCATCTCCATAAAAATCCCTAAACGAAACATGCCCACGTGTCCGGAGATTTTCAGGACTTGGTGCATTTCAGA
TGAAGGCTTTTCCAGAAGCTTCCCCGTAGAAGAGGATCAGGCATCCAACTGGTTAAGGGATGCCAGAAGGGCCGTTGGTGAGGAAATTTC
ACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAGCAGTAAGAAGCTACAGCCCGCCAGCCTGCAGTCTCTGT
GGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACAC
CAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGAT
CCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGC
TGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACC
CTTCCCCGAGCATTTTTTGTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTG
TGCTGAGCAGGATACCTGAACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTG
GAAGAAGAGGCCAGTATGAGATGCTGTCAGAGTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTG
CTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCC
CTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGA
AAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGG
AGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGC
AGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACC
TCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCA
TACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGA
AATCCTGCTACAACCTCACCAACCCCAGTGATTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATA
CAATTACTTTGCCAGACTTCAGCGATCCCGAGACAGGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCACTGTCGG
AAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATGCAGCTG
AAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATGTCCTCT
ACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCACCCACG
TGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGCAGGTGA
ACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCCTGACAG
CCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACCTGCCGC
TCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGAGTGTTC
AGTGGGCCACAGTGAACCAACCAAACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAATGGTAG
TTTCTGAACCTATTGACATTGTTCAAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTATGGAATT
AATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAACTGTCC
TTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCATGCCAGG
ACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAGTCCGAG
AATATTTATATTTTACCAATATATGCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAGAGTTTA
TTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATGGAATATTTACCGACATTCCTTATACATGACAGACACTTGGCTACATGGGAAGA

>58491_58491_1_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000284503_TTC7B_chr14_91146879_ENST00000328459_length(amino acids)=690AA_BP=163
MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVG
EPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPSIFCPQENTEEALLLLL
ISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKEC
IRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPT
DHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEAL
LTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWM
TLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLA

--------------------------------------------------------------
>58491_58491_2_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000284503_TTC7B_chr14_91146879_ENST00000357056_length(transcript)=3502nt_BP=1090nt
GCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGTGAGTGCAGCCGCCCGCCCTCCGGTAGATCTGCGGC
CTGGCGGAGAAGTCGGGAGGGGACAGGAAGGGAGGGCGGGCCCCGGGCCCTCCTCCGTCTCAGCCGCCTGCGGAGGTGCTGCCCACGCCT
GGAGGCCCCCACTGACCCTCAGACCCGCGTCTGCGCCCCTCTCCCCGCACCCCGAGGCAGAGTTGGGAAAGCAGTGGTCTTAGACCCCCC
ACCTCGGGCACTCGGAAGAGAACGGCGGAGACAACCCCTCCTCTTCCCTGGCTGGCGCAGCGCCAGCCTCGAGCTCCTCGGTAGCCCCCG
GGCAGGGAGGGCCGGAGGGTGGGCGCGGCATCTTCAGCGACTCTTCGAAGTCCCTTCCGCGTCTCATCTTTCAAGGCTGTTGCAGAGGCG
GCTTGCTTCCCACCTGTCCATCTCCATAAAAATCCCTAAACGAAACATGCCCACGTGTCCGGAGATTTTCAGGACTTGGTGCATTTCAGA
TGAAGGCTTTTCCAGAAGCTTCCCCGTAGAAGAGGATCAGGCATCCAACTGGTTAAGGGATGCCAGAAGGGCCGTTGGTGAGGAAATTTC
ACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAGCAGTAAGAAGCTACAGCCCGCCAGCCTGCAGTCTCTGT
GGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACAC
CAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGAT
CCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGC
TGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACC
CTTCCCCGAGCATTTTTTGTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTG
TGCTGAGCAGGATACCTGAACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTG
GAAGAAGAGGCCAGTATGAGATGCTGTCAGAGTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTG
CTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCC
CTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGA
AAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGG
AGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGC
AGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACC
TCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCA
TACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGA
AATCCTGCTACAACCTCACCAACCCCAGTGATTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATA
CAATTACTTTGCCAGACTTCAGCGATCCCGAGACAGGCAACTCTCCAGAAGCATACTTTCATGGTTTTCCTTCCCTTTTTTCAGTTAGCT
CCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCAGG
GCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCACAG
CCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCATGG
ACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCAGC
TAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGAGG
TCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTTCA
CCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGTGC
CATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAATCA
TCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCATGTG
CCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAATT
CAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCCAG
AAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAATT
GTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAGAGA
AGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATGGA

>58491_58491_2_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000284503_TTC7B_chr14_91146879_ENST00000357056_length(amino acids)=707AA_BP=163
MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVG
EPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPSIFCPQENTEEALLLLL
ISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKEC
IRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPT
DHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEAL
LTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGNSPEAYFHGFPSLFSVSSVHATSVAASRVEQALSEVA
SSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKS

--------------------------------------------------------------
>58491_58491_3_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000403422_TTC7B_chr14_91146879_ENST00000328459_length(transcript)=2797nt_BP=436nt
GAAATCTCCGCCCCCAGCTGGAGCGGCTGTGCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGTCCATG
GAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGC
AGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCC
CCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTG
GCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGCATTTTTTGTCCTC
AAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTGAACACA
AGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATGAGATGC
TGTCAGAGTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAA
AATCTGCCCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCA
TGGGCTCCCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAG
GCTACTTAGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTC
TTGCATTTCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCC
CAGAGGCTCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCAC
AGAAGCATTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGT
TGCAGTCACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACC
CCAGTGATTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCG
ATCCCGAGACAGGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCA
GTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGC
CTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGC
TCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCC
TGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGA
ACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCC
CCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGG
CACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAA
ACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTC
AAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATA
TTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGC
CCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTT
TTACTGTCAATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATAT
GCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAA
GAAGCTTCAAATGGAATATTTACCGACATTCCTTATACATGACAGACACTTGGCTACATGGGAAGATGATGTTAATAATAAAATGATTTT

>58491_58491_3_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000403422_TTC7B_chr14_91146879_ENST00000328459_length(amino acids)=666AA_BP=139
MERLCGLRSGAGSGRRATHPEPVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDD
SEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPSIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLI
SLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHW
LEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGY
VRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGR
GSSLLDRTIADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATA
CTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDAVQVNSTAHEVWNGLGEV

--------------------------------------------------------------
>58491_58491_4_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000403422_TTC7B_chr14_91146879_ENST00000357056_length(transcript)=2848nt_BP=436nt
GAAATCTCCGCCCCCAGCTGGAGCGGCTGTGCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGTCCATG
GAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGC
AGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCC
CCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTG
GCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGAGGGACCCTTCCCCGAGCATTTTTTGTCCTC
AAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTGAACACA
AGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATGAGATGC
TGTCAGAGTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAA
AATCTGCCCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCA
TGGGCTCCCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAG
GCTACTTAGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTC
TTGCATTTCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCC
CAGAGGCTCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCAC
AGAAGCATTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGT
TGCAGTCACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACC
CCAGTGATTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCG
ATCCCGAGACAGGCAACTCTCCAGAAGCATACTTTCATGGTTTTCCTTCCCTTTTTTCAGTTAGCTCCGTCCATGCCACATCGGTAGCAG
CCTCAAGAGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGC
TGGCACAGATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACC
TCTTCCCAATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAG
AGGCCTTAGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGA
AGATCCTCCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATG
CGGCGGCTACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAG
CAGGCGCCTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTG
CCACACTGAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTC
TTGTTTTTTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTG
AGTTTTCAGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTA
TCAGAGCTGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCT
CCCACCTCAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAATTGTACCATGTGATCAATTACTGTCC
TCACTTAGAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTT
AACTTTTTTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATGGAATATTTACCGACATTCCTTATACA

>58491_58491_4_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000403422_TTC7B_chr14_91146879_ENST00000357056_length(amino acids)=683AA_BP=139
MERLCGLRSGAGSGRRATHPEPVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDD
SEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPSIFCPQENTEEALLLLLISESMANRDAVLSRIPEHKSDRLI
SLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKECIRLKPDDATIPLLAAKLCMGSLHW
LEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPTDHQAAFYLALQLAISRQIPEALGY
VRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEALLTCKHMLQIWKSCYNLTNPSDSGR
GSSLLDRTIADRRQLNTITLPDFSDPETGNSPEAYFHGFPSLFSVSSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWMTLAQIWL
HAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLAEKILRDA

--------------------------------------------------------------
>58491_58491_5_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000436750_TTC7B_chr14_91146879_ENST00000328459_length(transcript)=3007nt_BP=646nt
GGAGCCCCGCAGCCTCCACCTACAGGGGCGTCCCCTAAGGGGACGGAGGCCGCATGGGCCGCCGAGCCGGGAAATCTCCGCCCCCAGCTG
GAGCGGCTGTGCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGGATGCCAGAAGGGCCGTTGGTGAGGA
AATTTCACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAGCAGTAAGAAGCTACAGCCCGCCAGCCTGCAGT
CTCTGTGGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCC
CAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTG
ATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGA
GGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGA
GGGACCCTTCCCCGAGCATTTTTTGTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGG
ACGCTGTGCTGAGCAGGATACCTGAACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTG
CTCTTGGAAGAAGAGGCCAGTATGAGATGCTGTCAGAGTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACC
AGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCA
CCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGG
GAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGA
TGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGG
CTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCC
TGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAA
ATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGA
TATGGAAATCCTGCTACAACCTCACCAACCCCAGTGATTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGC
TTAATACAATTACTTTGCCAGACTTCAGCGATCCCGAGACAGGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCAC
TGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATG
CAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATG
TCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCA
CCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGC
AGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCC
TGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACC
TGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGA
GTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAA
TGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTAT
GGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAA
CTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCAT
GCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAG
TCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAG
AGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATGGAATATTTACCGACATTCCTTATACATGACAGACACTTGGCTACATG

>58491_58491_5_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000436750_TTC7B_chr14_91146879_ENST00000328459_length(amino acids)=690AA_BP=163
MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVG
EPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPSIFCPQENTEEALLLLL
ISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKEC
IRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPT
DHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEAL
LTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWM
TLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLA

--------------------------------------------------------------
>58491_58491_6_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000436750_TTC7B_chr14_91146879_ENST00000357056_length(transcript)=3058nt_BP=646nt
GGAGCCCCGCAGCCTCCACCTACAGGGGCGTCCCCTAAGGGGACGGAGGCCGCATGGGCCGCCGAGCCGGGAAATCTCCGCCCCCAGCTG
GAGCGGCTGTGCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAGCCGGGATGCCAGAAGGGCCGTTGGTGAGGA
AATTTCACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAGCAGTAAGAAGCTACAGCCCGCCAGCCTGCAGT
CTCTGTGGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCCCTGGCAGCAGCC
CAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGCAGAAGACCCTTG
ATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAGGAGATGCTGGGA
GGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGAGGGGGGACTGGA
GGGACCCTTCCCCGAGCATTTTTTGTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAATGGCCAACCGGG
ACGCTGTGCTGAGCAGGATACCTGAACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACTTACTCACCATTG
CTCTTGGAAGAAGAGGCCAGTATGAGATGCTGTCAGAGTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCCACCTGTGGTACC
AGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGCCAGACGATGCCA
CCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTGTCGTTGATGTGG
GAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTTCTTTGCGAGGGA
TGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAGCTTTCTACCTGG
CTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACGATGCCAACTCCC
TGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTGAATACCCAGAAA
ATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGCACATGCTGCAGA
TATGGAAATCCTGCTACAACCTCACCAACCCCAGTGATTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTGACAGACGACAGC
TTAATACAATTACTTTGCCAGACTTCAGCGATCCCGAGACAGGCAACTCTCCAGAAGCATACTTTCATGGTTTTCCTTCCCTTTTTTCAG
TTAGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTA
AGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAG
CCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAA
GCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTC
ACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGG
GCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGC
CCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGC
TTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCC
GAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGAT
CATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTT
AAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTG
GCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCA
ATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTAC
AAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCA

>58491_58491_6_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000436750_TTC7B_chr14_91146879_ENST00000357056_length(amino acids)=707AA_BP=163
MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVG
EPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPSIFCPQENTEEALLLLL
ISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKEC
IRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPT
DHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEAL
LTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGNSPEAYFHGFPSLFSVSSVHATSVAASRVEQALSEVA
SSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKS

--------------------------------------------------------------
>58491_58491_7_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000455213_TTC7B_chr14_91146879_ENST00000328459_length(transcript)=3109nt_BP=748nt
GCCGAGCCGGGAAATCTCCGCCCCCAGCTGGAGCGGCTGTGCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAG
CCGGCTGTTGCAGAGGCGGCTTGCTTCCCACCTGTCCATCTCCATAAAAATCCCTAAACGAAACATGCCCACGTGTCCGGAGATTTTCAG
GACTTGGTGCATTTCAGATGAAGGCTTTTCCAGAAGCTTCCCCGTAGAAGAGGATCAGGCATCCAACTGGTTAAGGGATGCCAGAAGGGC
CGTTGGTGAGGAAATTTCACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAGCAGTAAGAAGCTACAGCCCG
CCAGCCTGCAGTCTCTGTGGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCC
CTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGC
AGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAG
GAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGA
GGGGGGACTGGAGGGACCCTTCCCCGAGCATTTTTTGTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAA
TGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTGAACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACT
TACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATGAGATGCTGTCAGAGTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCC
ACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGC
CAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTG
TCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTT
CTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAG
CTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACG
ATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTG
AATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGC
ACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACCCCAGTGATTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTG
ACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCGATCCCGAGACAGGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAG
TGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGAGCAGTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGA
TCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGAAGCCTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAA
TGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTGAGCTCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAG
CCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGGCCCTGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCC
GGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCTGGAACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTA
CGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCAGCCCCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCT
GCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCCGGGCACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGA
GGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAACCAAACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTT
TTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTGTTCAAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAG
TAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAATATATTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTG
TAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCCTGCCCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCA
GCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTGGTTTTACTGTCAATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGA
ACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATATATGCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTT
ATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTACAAAGAAGCTTCAAATGGAATATTTACCGACATTCCTTATACATGACAGACA

>58491_58491_7_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000455213_TTC7B_chr14_91146879_ENST00000328459_length(amino acids)=690AA_BP=163
MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVG
EPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPSIFCPQENTEEALLLLL
ISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKEC
IRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPT
DHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEAL
LTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGSVHATSVAASRVEQALSEVASSLQSSAPKQGPLHPWM
TLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKSMQRLALILHQLGRYSLA

--------------------------------------------------------------
>58491_58491_8_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000455213_TTC7B_chr14_91146879_ENST00000357056_length(transcript)=3160nt_BP=748nt
GCCGAGCCGGGAAATCTCCGCCCCCAGCTGGAGCGGCTGTGCGGGCTGCGTAGCGGTGCTGGGTCGGGCCGACGTGCCACCCACCCGGAG
CCGGCTGTTGCAGAGGCGGCTTGCTTCCCACCTGTCCATCTCCATAAAAATCCCTAAACGAAACATGCCCACGTGTCCGGAGATTTTCAG
GACTTGGTGCATTTCAGATGAAGGCTTTTCCAGAAGCTTCCCCGTAGAAGAGGATCAGGCATCCAACTGGTTAAGGGATGCCAGAAGGGC
CGTTGGTGAGGAAATTTCACCATTTGGTCTCCCCCTTTGTGGGTCAGCAGGTGGTCAAGACAGGGGGCAGCAGTAAGAAGCTACAGCCCG
CCAGCCTGCAGTCTCTGTGGCTCCAGGACACCCAGGTCCATGGAAAGAAATTATTCCTTAGATTTGATCTAGATGAAGAAATGGGGCCCC
CTGGCAGCAGCCCAACACCAGAGCCTCCACAAAAAGAAGTGCAGAAGGAAGGGGCTGCGGACCCAAAGCAGGTCGGGGAGCCCAGCGGGC
AGAAGACCCTTGATGGATCCTCACGGTCTGCAGAGCTCGTCCCCCAGGGCGAGGATGATTCTGAGTATTTGGAGAGAGACGCCCCTGCAG
GAGATGCTGGGAGGTGGCTGCGTGTCAGCTTTGGTTTGTTTGGCAGCGTTTGGGTGAACGATTTCTCCAGAGCCAAGAAAGCCAACAAGA
GGGGGGACTGGAGGGACCCTTCCCCGAGCATTTTTTGTCCTCAAGAAAATACGGAAGAAGCCCTGTTGTTATTGCTGATTAGTGAATCAA
TGGCCAACCGGGACGCTGTGCTGAGCAGGATACCTGAACACAAGAGTGACCGCCTCATCAGTCTGCAGAGTGCATCTGTGGTCTATGACT
TACTCACCATTGCTCTTGGAAGAAGAGGCCAGTATGAGATGCTGTCAGAGTGCCTAGAAAGAGCCATGAAGTTTGCCTTTGAGGAATTCC
ACCTGTGGTACCAGTTTGCTCTGTCCCTGATGGCTGCTGGAAAATCTGCCCGTGCCGTGAAGGTGCTGAAAGAGTGTATCCGCCTGAAGC
CAGACGATGCCACCATCCCTCTCCTCGCTGCCAAGCTCTGCATGGGCTCCCTGCACTGGTTGGAAGAGGCTGAAAAGTTTGCCAAAACTG
TCGTTGATGTGGGAGAGAAAACGTCAGAGTTCAAGGCCAAAGGCTACTTAGCTCTGGGGCTCACGTACAGTCTGCAGGCCACTGACGCTT
CTTTGCGAGGGATGCAGGAGGTCCTACAGAGAAAGGCGCTTCTTGCATTTCAGAGGGCCCACAGCCTGTCACCCACAGATCACCAAGCAG
CTTTCTACCTGGCTCTGCAGCTTGCCATCTCCAGACAGATCCCAGAGGCTCTGGGGTATGTCCGCCAAGCTCTTCAGCTTCAAGGTGACG
ATGCCAACTCCCTGCACCTCCTTGCCCTCCTGCTGTCAGCACAGAAGCATTACCATGACGCTCTGAACATCATCGACATGGCCCTGAGTG
AATACCCAGAAAATTTCATACTACTGTTTTCCAAAGTGAAGTTGCAGTCACTCTGCCGAGGCCCGGACGAGGCACTGCTGACTTGTAAGC
ACATGCTGCAGATATGGAAATCCTGCTACAACCTCACCAACCCCAGTGATTCTGGACGTGGGAGCAGCCTCTTAGATAGAACCATTGCTG
ACAGACGACAGCTTAATACAATTACTTTGCCAGACTTCAGCGATCCCGAGACAGGCAACTCTCCAGAAGCATACTTTCATGGTTTTCCTT
CCCTTTTTTCAGTTAGCTCCGTCCATGCCACATCGGTAGCAGCCTCAAGAGTGGAGCAGGCACTGTCGGAAGTGGCTTCGTCTCTGCAGA
GCAGTGCCCCTAAGCAGGGCCCGCTGCACCCCTGGATGACGCTGGCACAGATCTGGCTCCATGCAGCTGAAGTCTATATCGGCATCGGGA
AGCCTGCAGAAGCCACAGCCTGTACCCAAGAAGCTGCCAACCTCTTCCCAATGTCCCACAATGTCCTCTACATGCGCGGCCAGATTGCTG
AGCTCCGGGGAAGCATGGACGAGGCGCGGCGGTGGTATGAAGAGGCCTTAGCCATCAGCCCCACCCACGTGAAGAGCATGCAGCGACTGG
CCCTGATCCTTCACCAGCTAGGCCGCTACAGTCTGGCGGAGAAGATCCTCCGGGACGCGGTGCAGGTGAACTCGACAGCCCACGAGGTCT
GGAACGGGCTGGGCGAGGTCCTCCAAGCTCAGGGCAACGATGCGGCGGCTACGGAGTGCTTCCTGACAGCCTTGGAGCTGGAGGCCAGCA
GCCCCGCCGTGCCCTTCACCATCATCCCCCGCGTGCTCTGAGCAGGCGCCTGCCAGCCTCACCTGCCGCTCAGGCCTCAGAGGCCCTGCC
GGGCACCAGGGCTTGTGCCATCGCCCCAAGGGGATGAATCTGCCACACTGAGGCCAGGGACGAGTGTTCAGTGGGCCACAGTGAACCAAC
CAAACCAACCCCGAATCATCGCTCTCGCCATGTGCGTTTCTCTTGTTTTTTTTGCCAGCCCAATGGTAGTTTCTGAACCTATTGACATTG
TTCAAAATGGATCATGTGCCATATTTTGTTAGTTGACATCTGAGTTTTCAGTAAAATGATTATGGAATTAATCAGCAAATGTAGAAGAAT
ATATTCAAAGTTAAAATTCAGTGGCAGCACAGATTATTTTTATCAGAGCTGTAAAGAAAACAACTGTCCTTTTCTCCCCACCACCCCTCC
TGCCCCACTTTGGCCCAGAAACCAAATGTGAACTTCCTGTCTCCCACCTCAGCACTAGTCCATGCCAGGACACCAGCTGACAATTTCTTG
GTTTTACTGTCAATAATTGTACCATGTGATCAATTACTGTCCTCACTTAGAACAAAGCCTGAGTCCGAGAATATTTATATTTTACCAATA
TATGCCTGTTACAAGAGAAGGAAATATGAGTTATTTAAGTTTAACTTTTTTATGTGAATTCAGAGTTTATTTATCGAGGGAAATATGTAC
AAAGAAGCTTCAAATGGAATATTTACCGACATTCCTTATACATGACAGACACTTGGCTACATGGGAAGATGATGTTAATAATAAAATGAT

>58491_58491_8_NEIL2-TTC7B_NEIL2_chr8_11637459_ENST00000455213_TTC7B_chr14_91146879_ENST00000357056_length(amino acids)=707AA_BP=163
MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVG
EPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPSIFCPQENTEEALLLLL
ISESMANRDAVLSRIPEHKSDRLISLQSASVVYDLLTIALGRRGQYEMLSECLERAMKFAFEEFHLWYQFALSLMAAGKSARAVKVLKEC
IRLKPDDATIPLLAAKLCMGSLHWLEEAEKFAKTVVDVGEKTSEFKAKGYLALGLTYSLQATDASLRGMQEVLQRKALLAFQRAHSLSPT
DHQAAFYLALQLAISRQIPEALGYVRQALQLQGDDANSLHLLALLLSAQKHYHDALNIIDMALSEYPENFILLFSKVKLQSLCRGPDEAL
LTCKHMLQIWKSCYNLTNPSDSGRGSSLLDRTIADRRQLNTITLPDFSDPETGNSPEAYFHGFPSLFSVSSVHATSVAASRVEQALSEVA
SSLQSSAPKQGPLHPWMTLAQIWLHAAEVYIGIGKPAEATACTQEAANLFPMSHNVLYMRGQIAELRGSMDEARRWYEEALAISPTHVKS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NEIL2-TTC7B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NEIL2-TTC7B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NEIL2-TTC7B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source