FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ARFGEF1-CSPP1 (FusionGDB2 ID:5851)

Fusion Gene Summary for ARFGEF1-CSPP1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARFGEF1-CSPP1
Fusion gene ID: 5851
HgeneTgene
Gene symbol

ARFGEF1

CSPP1

Gene ID

10565

79848

Gene nameADP ribosylation factor guanine nucleotide exchange factor 1centrosome and spindle pole associated protein 1
SynonymsARFGEP1|BIG1|P200CSPP|CSPP-L|JBTS21
Cytomap

8q13.2

8q13.1-q13.2

Type of geneprotein-codingprotein-coding
Descriptionbrefeldin A-inhibited guanine nucleotide-exchange protein 1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)p200 ARF guanine nucleotide exchange factorcentrosome and spindle pole-associated protein 1
Modification date2020031320200313
UniProtAcc

Q9Y6D6

Q1MSJ5

Ensembl transtripts involved in fusion geneENST00000262215, ENST00000520381, 
ENST00000518230, ENST00000517955, 
ENST00000521168, ENST00000262210, 
ENST00000412460, 
Fusion gene scores* DoF score14 X 14 X 6=117611 X 9 X 4=396
# samples 1711
** MAII scorelog2(17/1176*10)=-2.79028140869866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARFGEF1 [Title/Abstract] AND CSPP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARFGEF1(68150578)-CSPP1(68024207), # samples:2
CSPP1(68071224)-ARFGEF1(68089957), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARFGEF1

GO:0034260

negative regulation of GTPase activity

15644318


check buttonFusion gene breakpoints across ARFGEF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CSPP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-RU-A8FL-01AARFGEF1chr8

68150578

-CSPP1chr8

68024207

+


Top

Fusion Gene ORF analysis for ARFGEF1-CSPP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000262215ENST00000521168ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
5CDS-intronENST00000520381ENST00000521168ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
5UTR-3CDSENST00000518230ENST00000262210ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
5UTR-3CDSENST00000518230ENST00000412460ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
5UTR-intronENST00000518230ENST00000521168ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
In-frameENST00000262215ENST00000262210ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
In-frameENST00000262215ENST00000412460ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
In-frameENST00000520381ENST00000262210ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
In-frameENST00000520381ENST00000412460ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
intron-3CDSENST00000517955ENST00000262210ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
intron-3CDSENST00000517955ENST00000412460ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+
intron-intronENST00000517955ENST00000521168ARFGEF1chr8

68150578

-CSPP1chr8

68024207

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000520381ARFGEF1chr868150578-ENST00000412460CSPP1chr868024207+477817193241111359
ENST00000520381ARFGEF1chr868150578-ENST00000262210CSPP1chr868024207+493517193242641410
ENST00000262215ARFGEF1chr868150578-ENST00000412460CSPP1chr868024207+6738367939060711893
ENST00000262215ARFGEF1chr868150578-ENST00000262210CSPP1chr868024207+6895367939062241944

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000520381ENST00000412460ARFGEF1chr868150578-CSPP1chr868024207+0.0007080790.9992919
ENST00000520381ENST00000262210ARFGEF1chr868150578-CSPP1chr868024207+0.0004837340.99951625
ENST00000262215ENST00000412460ARFGEF1chr868150578-CSPP1chr868024207+0.0015044460.9984956
ENST00000262215ENST00000262210ARFGEF1chr868150578-CSPP1chr868024207+0.0009997280.99900025

Top

Fusion Genomic Features for ARFGEF1-CSPP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARFGEF1chr868150577-CSPP1chr868024206+8.24E-070.99999917
ARFGEF1chr868150577-CSPP1chr868024206+8.24E-070.99999917

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for ARFGEF1-CSPP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:68150578/chr8:68024207)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARFGEF1

Q9Y6D6

CSPP1

Q1MSJ5

FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269|PubMed:12571360, ECO:0000269|PubMed:15644318, ECO:0000269|PubMed:17227842, ECO:0000269|PubMed:20360857, ECO:0000269|PubMed:22084092}.FUNCTION: May play a role in cell-cycle-dependent microtubule organization. {ECO:0000269|PubMed:16826565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARFGEF1chr8:68150578chr8:68024207ENST00000262215-2239709_84010961850.0DomainSEC7
HgeneARFGEF1chr8:68150578chr8:68024207ENST00000262215-2239711_71510961850.0MotifNote=Nuclear localization signal (NLS)
TgeneCSPP1chr8:68150578chr8:68024207ENST00000262210729417_4493731222.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000262210729625_6693731222.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000262210729925_9643731222.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000412460930114_13579877.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000412460930244_27079877.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000412460930417_44979877.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000412460930625_66979877.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000412460930925_96479877.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000262210729478_5413731222.0Compositional biasNote=Pro-rich
TgeneCSPP1chr8:68150578chr8:68024207ENST00000262210729672_6773731222.0Compositional biasNote=Poly-Gly
TgeneCSPP1chr8:68150578chr8:68024207ENST00000262210729779_8553731222.0Compositional biasNote=Glu-rich
TgeneCSPP1chr8:68150578chr8:68024207ENST00000412460930478_54179877.0Compositional biasNote=Pro-rich
TgeneCSPP1chr8:68150578chr8:68024207ENST00000412460930672_67779877.0Compositional biasNote=Poly-Gly
TgeneCSPP1chr8:68150578chr8:68024207ENST00000412460930779_85579877.0Compositional biasNote=Glu-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCSPP1chr8:68150578chr8:68024207ENST00000262210729114_1353731222.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST00000262210729244_2703731222.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST0000026221072938_623731222.0Coiled coilOntology_term=ECO:0000255
TgeneCSPP1chr8:68150578chr8:68024207ENST0000041246093038_6279877.0Coiled coilOntology_term=ECO:0000255


Top

Fusion Gene Sequence for ARFGEF1-CSPP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5851_5851_1_ARFGEF1-CSPP1_ARFGEF1_chr8_68150578_ENST00000262215_CSPP1_chr8_68024207_ENST00000262210_length(transcript)=6895nt_BP=3679nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGAGGAAATAAAAGCGGAAACTGAAAAA
CAGAGTCCTCCTCATGGAGAAGCAAAAGCTGGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTAGATTGCTTACAGAAACTTATTGCTTATGGG
CACTTGACTGGCAATGCTCCAGATAGTACAACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGCTTTACTTACTGCAGTAACATCACAACACATAGAAATTCATGAAGGGACT
GTACTGCAAGCTGTGAGAACATGTTACAATATCTACTTAGCAAGCAAAAATCTCATCAATCAGACAACAGCCAAAGCTACTCTCACTCAG
ATGCTAAATGTTATCTTTGCACGCATGGAAAACCAAGCATTACAGGAAGCAAAACAAATGGAAAAAGAAAGGCATCGGCAGCATCATCAT
CTGTTACAGTCTCCAGTAAGCCATCACGAGCCTGAATCACCTCAACTTAGATATTTGCCACCTCAGACTGTTGATCATATATCCCAAGAA
CACGAAGGGGACCTTGACCTCCATACAAATGATGTAGATAAAAGTCTTCAGGATGACACAGAGCCTGAAAATGGATCTGATATTTCCAGT
GCAGAAAATGAACAGACTGAAGCTGATCAGGCAACTGCAGCTGAAACATTATCTAAAAATGAAGTGTTATATGACGGAGAAAACCATGAT
TGTGAGGAAAAGCCACAAGACATTGTACAGAACATTGTAGAAGAAATGGTGAACATTGTTGTTGGAGATATGGGAGAAGGGACTACTATA
AATGCAAGTGCAGATGGCAACATTGGAACTATAGAGGATGGTAGTGACAGTGAAAATATTCAAGCAAATGGAATTCCAGGAACACCAATT
TCTGTTGCATATACACCATCCTTACCTGATGATAGATTGTCAGTCTCTTCCAATGATACTCAGGAATCTGGAAATTCTTCAGGACCTTCA
CCTGGTGCTAAGTTTTCCCACATTTTACAAAAGGATGCCTTTCTAGTATTCAGGTCATTGTGTAAACTGTCAATGAAACCACTGTCAGAT
GGACCACCAGATCCAAAGTCTCATGAACTACGATCCAAGATTCTTTCATTGCAGTTACTTCTATCCATTCTGCAGAATGCAGGACCTATT
TTCAGGACAAATGAGATGTTTATTAATGCTATTAAGCAGTATCTTTGTGTTGCACTCTCAAAAAATGGAGTCTCATCTGTTCCAGAGGTT
TTTGAGCTTTCTCTTTCTATATTTCTTACTTTGTTGTCAAATTTCAAGACACATCTGAAGATGCAAATTGAGGTGTTCTTTAAAGAAATT
TTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGAGGATTTGTGCAGATGCTCAG
AGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAAATGATCTATCAAAAATTGCT
CAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAGAATGCTTAGTGTCGATTTTG
AAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAAAACCCTCAGAGCAAGAGATG
AGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCATCAGGAATAGGCAGCTACAGT
ACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAACAAGGGATAGATTTATTTAAT
AAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTGCCCAATTCTTACATCAAGAG
GAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGTATGCATATGTGGACCAACAT
GACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAGCTCAGAAAATCGATCGATTA
ATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAGCTTATGTTTTGGCTTATTCA
ATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTAAGATGAATAGAGGTATCAAT
GACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAATGAAAGAAACAAAAGAACTA
ACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAGAAATGGAGCAGATGGCCAAG
ACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGCATGTGAGGCCCATGTTTAAG
TTGGCTTGGACGCCTTTTCTGGCTGCATTCAGTGTGGGTCTACAAGATTGTGATGATACTGAAGTAGCCTCTCTTTGCCTGGAAGGTATA
AGATGTGCAATCAGAATTGCATGCATTTTCAGCATTCAGCTGGAGAGAGATGCATATGTCCAGGCACTAGCAAGATTTACCTTACTCACA
GTGAGTTCCGGTATTACTGAAATGAAACAGAAGAACATTGACACAATAAAAACACTTATCACAGTGGCTCATACAGATGGAAATTATTTA
GGAAATTCATGGCATGAGATTCTGAAGTGCATCAGTCAGTTGGAGCTGGCACAGCTTATAGGAACTGGAGTGAAACCTCGATACATTTCT
GGAACAGTGCGAGGCAGAGAAGGATCTCTTACTGGAACAAAAGATCAGGCTCCTGATGAATTTGTGGGTTTAGGGCTAGGAGGTGAAGAT
CGAGAACTTATTCAGAGAAGGAAAGAGAAATACAGACTAGAACTGTTGGAACAAATGGCTGAGCAACAGAGGAACAAGAGACGAGAAAAA
GATTTAGAACTCAGGGTTGCAGCGTCTGGAGCACAAGACCCTGAGAAATCGCCTGATAGACTAAAGCAGTTTAGTGTGGCACCAAGACAC
TTTGAAGAGATGATACCACCTGAAAGACCCAGAATAGCTTTCCAGACACCTCTCCCTCCTTTATCTGCCCCATCTGTCCCACCCATCCCA
TCAGTTCATCCTGTTCCTTCTCAAAATGAAGATTTGCGCAGTGGACTCAGCAGCGCCCTTGGTGAAATGGTGTCTCCCAGGATTGCACCT
CTGCCTCCACCTCCCCTACTACCACCTTTGGCTACTAACTATCGAACTCCTTATGATGATGCATACTATTTTTATGGGTCCAGGAATACT
TTCGATCCCAGTCTTGCTTATTATGGTTCAGGAATGATGGGCGTACAGCCTGCAGCTTATGTTAGTGCTCCTGTCACCCACCAACTAGCA
CAACCTGTTGTGAATACGGTTGGACAGAATGAACTGAAGATTACAAGTGATCAAGTGATAAATTCAGGATTGATTTTTGAAGATAAACCG
AAACCTTCCAAACAGTCACTTCAGTCTTACCAAGAGGCTTTGCAGCAGCAGATTCGGGAAAGAGAAGAAAGAAGGAAGAAAGAACGTGAA
GAAAAAGAAGAATATGAAGCTAAATTAGAAGCTGAAATGAGAACATATAATCCCTGGGGAAAAGGTGGAGGTGGTGCTCCTCTCAGGGAT
GCAAAAGGAAATCTGATAACTGATTTGAATAGGATGCACAGACAAAATATAGATGCCTACCATAACCCAGATGCAAGAACATATGAAGAT
AAAAGGGCTGTTGTATCTCTAGACCCAAATTTAGCCACTTCAAATGCTGAGAACCTAGAAGATGCTGCAAATAAAAGCTCAGGTCATATG
CAAACACAGAGCTCTCCTTTTGCTCGGGGAAATGTATTTGGTGAGCCTCCAACTGAACTTCAGATTAAACAGCAAGAATTATACAAGAAT
TTTCTTCGTTTCCAGATTGAGGAAAAGAAACAAAGAGAGGAAGCAGAGCGAGAGAGACTGAGAATTGCAGAAGAAAAAGAAGAAAGACGG
CTTGCAGAACAGAGGGCACGAATTCAGCAGGAGTATGAAGAGGAACAGGAAAAGAAAAGAGAGAAAGAGGAGGAGCAAAGGCTAAAAAAT
GAAGAGCATATTCGGTTAGCTGAAGAAAGACAAAAAGAAGCAGAAAGAAAGAAGAAAGAAGAAGAAGAAAAATATAACCTGCAACTTCAG
CACTACTGTGAAAGAGACAATTTGATTGGGGAAGAAACAAAGCACATGAGACAGCCTTCTCCTATAGTTCCTGCTCTTCAGAACAAAATT
GCAAGCAAACTCCAAAGACCTCCTTCAGTTGACAGCATCATACGTTCCTTTATTCATGAAAGTTCCATGTCCAGGGCACAGTCACCCCCG
GTACCTGCCAGGAAAAATCAGCTCCGTGCAGAAGAGGAGAAAAAAAATGTAATTATGGAATTATCAGAAATGAGAAAACAGCTTCGTAGT
GAAGAGAGGCGTCTACAAGAGCGATTGCTACACATGGACAGTGATGATGAAATTCCTATCAGGAAAAAGGAAAGGAATCCCATGGATATA
TTTGATATGGCTAGACATCGGTTGCAAGCTCCTGTCAGAAGACAGTCCCCTAAGGGCTTAGACGCTGCCACTTTTCAGAATGTTCATGAT
TTTAATGAGCTGAAAGATAGAGATTCAGAAACACGAGTTGATCTGAAATTTATGTACCTGGATCCTCCAAGAGATCATCACACCTTAGAG
ATTCAGCAGCAAGCCCTGCTAAGAGAGCAGCAGAAGAGGCTGAACAGAATAAAAATGCAGGAAGGTGCCAAAGTTGACTTAGATGCCATC
CCAAGTGCTAAAGTACGAGAGCAAAGAATGCCCAGAGATGACACTAGTGATTTCTTGAAAAACTCATTATTGGAATCTGATAGTGCTTTT
ATTGGGGCTTACGGTGAGACATATCCTGCCATTGAAGATGACGTCCTCCCTCCACCATCACAGTTGCCCTCTGCACGGGAGCGCAGGAGG
AACAAATGGAAAGGACTAGACATTGATAGCAGTCGTCCTAATGTAGCACCAGATGGTCTCTCTCTAAAATCTATATCCAGTGTAAATGTT
GATGAGCTTAGAGTGAGAAATGAGGAACGAATGCGAAGACTGAATGAATTTCACAATAAACCTATTAATACAGATGATGAGAGTTCACTG
GTTGACCCTGATGACATCATGAAACACATAGGGGATGACGGATCAAACTCTGTAGCAACTGAGCCCTGGCTCCGCCCTGGCACTTCAGAA
ACGCTGAAACGTTTCATGGCAGAGCAGCTGAACCAGGAGCAGCAGCAGATTCCTGGAAAACCAGGCACTTTCACTTGGCAGGGCCTGTCG
ACTGCACATGGTTAAAATAAACCTGTACTGGACCCAGTAGTGCCTTTTAAGGTGAAAGGAATGGTAAATCTGTACCTTTAATATGTCCTA
CTTTTGGCCCCTACCTGAAAGTTACTTTTTTTCCATCATCTGTATATAAAATTATTTTTATCATGATGTATATTATGTACATAAATAAAA
GGCCATGATTATTGATTTATATAATAGAATTGTATAGATTATTTTTGCACAGTTTTGTCATAAATTAGGGTGGTAATGAACTGGATTGAA
CTACTATATGTGCATTATATTGAATTCTGCTTGTCATTAAGATAAGGTGAATAAGTGTCTTAAACGTCCTGTAAAACCGGACTCCCCTTT
GTTACATGCACATTTTCCATTGTTACCTCGATGCAAAAGAATTCATTTAGTAGGTACATCTATTGTAGCTGTGATTATTCCAGTTTCTGT
GTGATGCAATCAAATGTCCTATTAATTAATTATTATTTCATGTCATTTGTAGCTACTGATACAGCAGAAATGAAGGGAACTGTAATTACT
TGTATTTTTGTAAGCCATACGTTAAATGTTTGTTACATCATCTTTCTGCTTCTATTTTTATGCCAATGAAGGCATTTGTCTTGTTACTAA

>5851_5851_1_ARFGEF1-CSPP1_ARFGEF1_chr8_68150578_ENST00000262215_CSPP1_chr8_68024207_ENST00000262210_length(amino acids)=1944AA_BP=1095
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQS
KCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTN
DVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHEL
RSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQ
YVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLE
CNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIF
SIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL
TGTKDQAPDEFVGLGLGGEDRELIQRRKEKYRLELLEQMAEQQRNKRREKDLELRVAASGAQDPEKSPDRLKQFSVAPRHFEEMIPPERP
RIAFQTPLPPLSAPSVPPIPSVHPVPSQNEDLRSGLSSALGEMVSPRIAPLPPPPLLPPLATNYRTPYDDAYYFYGSRNTFDPSLAYYGS
GMMGVQPAAYVSAPVTHQLAQPVVNTVGQNELKITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIREREERRKKEREEKEEYEAKLE
AEMRTYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDARTYEDKRAVVSLDPNLATSNAENLEDAANKSSGHMQTQSSPFARG
NVFGEPPTELQIKQQELYKNFLRFQIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAEER
QKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKLQRPPSVDSIIRSFIHESSMSRAQSPPVPARKNQLRA
EEEKKNVIMELSEMRKQLRSEERRLQERLLHMDSDDEIPIRKKERNPMDIFDMARHRLQAPVRRQSPKGLDAATFQNVHDFNELKDRDSE
TRVDLKFMYLDPPRDHHTLEIQQQALLREQQKRLNRIKMQEGAKVDLDAIPSAKVREQRMPRDDTSDFLKNSLLESDSAFIGAYGETYPA
IEDDVLPPPSQLPSARERRRNKWKGLDIDSSRPNVAPDGLSLKSISSVNVDELRVRNEERMRRLNEFHNKPINTDDESSLVDPDDIMKHI

--------------------------------------------------------------
>5851_5851_2_ARFGEF1-CSPP1_ARFGEF1_chr8_68150578_ENST00000262215_CSPP1_chr8_68024207_ENST00000412460_length(transcript)=6738nt_BP=3679nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGAGGAAATAAAAGCGGAAACTGAAAAA
CAGAGTCCTCCTCATGGAGAAGCAAAAGCTGGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTAGATTGCTTACAGAAACTTATTGCTTATGGG
CACTTGACTGGCAATGCTCCAGATAGTACAACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGCTTTACTTACTGCAGTAACATCACAACACATAGAAATTCATGAAGGGACT
GTACTGCAAGCTGTGAGAACATGTTACAATATCTACTTAGCAAGCAAAAATCTCATCAATCAGACAACAGCCAAAGCTACTCTCACTCAG
ATGCTAAATGTTATCTTTGCACGCATGGAAAACCAAGCATTACAGGAAGCAAAACAAATGGAAAAAGAAAGGCATCGGCAGCATCATCAT
CTGTTACAGTCTCCAGTAAGCCATCACGAGCCTGAATCACCTCAACTTAGATATTTGCCACCTCAGACTGTTGATCATATATCCCAAGAA
CACGAAGGGGACCTTGACCTCCATACAAATGATGTAGATAAAAGTCTTCAGGATGACACAGAGCCTGAAAATGGATCTGATATTTCCAGT
GCAGAAAATGAACAGACTGAAGCTGATCAGGCAACTGCAGCTGAAACATTATCTAAAAATGAAGTGTTATATGACGGAGAAAACCATGAT
TGTGAGGAAAAGCCACAAGACATTGTACAGAACATTGTAGAAGAAATGGTGAACATTGTTGTTGGAGATATGGGAGAAGGGACTACTATA
AATGCAAGTGCAGATGGCAACATTGGAACTATAGAGGATGGTAGTGACAGTGAAAATATTCAAGCAAATGGAATTCCAGGAACACCAATT
TCTGTTGCATATACACCATCCTTACCTGATGATAGATTGTCAGTCTCTTCCAATGATACTCAGGAATCTGGAAATTCTTCAGGACCTTCA
CCTGGTGCTAAGTTTTCCCACATTTTACAAAAGGATGCCTTTCTAGTATTCAGGTCATTGTGTAAACTGTCAATGAAACCACTGTCAGAT
GGACCACCAGATCCAAAGTCTCATGAACTACGATCCAAGATTCTTTCATTGCAGTTACTTCTATCCATTCTGCAGAATGCAGGACCTATT
TTCAGGACAAATGAGATGTTTATTAATGCTATTAAGCAGTATCTTTGTGTTGCACTCTCAAAAAATGGAGTCTCATCTGTTCCAGAGGTT
TTTGAGCTTTCTCTTTCTATATTTCTTACTTTGTTGTCAAATTTCAAGACACATCTGAAGATGCAAATTGAGGTGTTCTTTAAAGAAATT
TTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGAGGATTTGTGCAGATGCTCAG
AGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAAATGATCTATCAAAAATTGCT
CAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAGAATGCTTAGTGTCGATTTTG
AAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAAAACCCTCAGAGCAAGAGATG
AGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCATCAGGAATAGGCAGCTACAGT
ACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAACAAGGGATAGATTTATTTAAT
AAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTGCCCAATTCTTACATCAAGAG
GAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGTATGCATATGTGGACCAACAT
GACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAGCTCAGAAAATCGATCGATTA
ATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAGCTTATGTTTTGGCTTATTCA
ATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTAAGATGAATAGAGGTATCAAT
GACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAATGAAAGAAACAAAAGAACTA
ACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAGAAATGGAGCAGATGGCCAAG
ACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGCATGTGAGGCCCATGTTTAAG
TTGGCTTGGACGCCTTTTCTGGCTGCATTCAGTGTGGGTCTACAAGATTGTGATGATACTGAAGTAGCCTCTCTTTGCCTGGAAGGTATA
AGATGTGCAATCAGAATTGCATGCATTTTCAGCATTCAGCTGGAGAGAGATGCATATGTCCAGGCACTAGCAAGATTTACCTTACTCACA
GTGAGTTCCGGTATTACTGAAATGAAACAGAAGAACATTGACACAATAAAAACACTTATCACAGTGGCTCATACAGATGGAAATTATTTA
GGAAATTCATGGCATGAGATTCTGAAGTGCATCAGTCAGTTGGAGCTGGCACAGCTTATAGGAACTGGAGTGAAACCTCGATACATTTCT
GGAACAGTGCGAGGCAGAGAAGGATCTCTTACTGGAACAAAAGATCAGGCTCCTGATGAATTTGTGGGTTTAGGGCTAGGAGGTGAAGAT
CGAGAACTTATTCAGAGAAGGAAAGAGAAATACAGACTAGAACTGTTGGAACAAATGGCTGAGCAACAGAGGAACAAGAGACGAGAAAAA
GATTTAGAACTCAGGGTTGCAGCGTCTGGAGCACAAGACCCTGAGAAATCGCCTGATAGACTAAAGCAGTTTAGTGTGGCACCAAGACAC
TTTGAAGAGATGATACCACCTGAAAGACCCAGAATAGCTTTCCAGACACCTCTCCCTCCTTTATCTGCCCCATCTGTCCCACCCATCCCA
TCAGTTCATCCTGTTCCTTCTCAAAATGAAGATTTGCGCAGTGGACTCAGCAGCGCCCTTGGTGAAATGGTGTCTCCCAGGATTGCACCT
CTGCCTCCACCTCCCCTACTACCACCTTTGGCTACTAACTATCGAACTCCTTATGATGATGCATACTATTTTTATGGGTCCAGGAATACT
TTCGATCCCAGTCTTGCTTATTATGGTTCAGGAATGATGGGCGTACAGCCTGCAGCTTATGTTAGTGCTCCTGTCACCCACCAACTAGCA
CAACCTGTTGTGAATACGGTTGGACAGAATGAACTGAAGATTACAAGTGATCAAGTGATAAATTCAGGATTGATTTTTGAAGATAAACCG
AAACCTTCCAAACAGTCACTTCAGTCTTACCAAGAGGCTTTGCAGCAGCAGATTCGGGAAAGAGAAGAAAGAAGGAAGAAAGAACGTGAA
GAAAAAGAAGAATATGAAGCTAAATTAGAAGCTGAAATGAGAACATATAATCCCTGGGGAAAAGGTGGAGGTGGTGCTCCTCTCAGGGAT
GCAAAAGGAAATCTGATAAGTCATATGCAAACACAGAGCTCTCCTTTTGCTCGGGGAAATGTATTTGGTGAGCCTCCAACTGAACTTCAG
ATTAAACAGCAAGAATTATACAAGAATTTTCTTCGTTTCCAGATTGAGGAAAAGAAACAAAGAGAGGAAGCAGAGCGAGAGAGACTGAGA
ATTGCAGAAGAAAAAGAAGAAAGACGGCTTGCAGAACAGAGGGCACGAATTCAGCAGGAGTATGAAGAGGAACAGGAAAAGAAAAGAGAG
AAAGAGGAGGAGCAAAGGCTAAAAAATGAAGAGCATATTCGGTTAGCTGAAGAAAGACAAAAAGAAGCAGAAAGAAAGAAGAAAGAAGAA
GAAGAAAAATATAACCTGCAACTTCAGCACTACTGTGAAAGAGACAATTTGATTGGGGAAGAAACAAAGCACATGAGACAGCCTTCTCCT
ATAGTTCCTGCTCTTCAGAACAAAATTGCAAGCAAACTCCAAAGACCTCCTTCAGTTGACAGCATCATACGTTCCTTTATTCATGAAAGT
TCCATGTCCAGGGCACAGTCACCCCCGGTACCTGCCAGGAAAAATCAGCTCCGTGCAGAAGAGGAGAAAAAAAATGTAATTATGGAATTA
TCAGAAATGAGAAAACAGCTTCGTAGTGAAGAGAGGCGTCTACAAGAGCGATTGCTACACATGGACAGTGATGATGAAATTCCTATCAGG
AAAAAGGAAAGGAATCCCATGGATATATTTGATATGGCTAGACATCGGTTGCAAGCTCCTGTCAGAAGACAGTCCCCTAAGGGCTTAGAC
GCTGCCACTTTTCAGAATGTTCATGATTTTAATGAGCTGAAAGATAGAGATTCAGAAACACGAGTTGATCTGAAATTTATGTACCTGGAT
CCTCCAAGAGATCATCACACCTTAGAGATTCAGCAGCAAGCCCTGCTAAGAGAGCAGCAGAAGAGGCTGAACAGAATAAAAATGCAGGAA
GGTGCCAAAGTTGACTTAGATGCCATCCCAAGTGCTAAAGTACGAGAGCAAAGAATGCCCAGAGATGACACTAGTGATTTCTTGAAAAAC
TCATTATTGGAATCTGATAGTGCTTTTATTGGGGCTTACGGTGAGACATATCCTGCCATTGAAGATGACGTCCTCCCTCCACCATCACAG
TTGCCCTCTGCACGGGAGCGCAGGAGGAACAAATGGAAAGGACTAGACATTGATAGCAGTCGTCCTAATGTAGCACCAGATGGTCTCTCT
CTAAAATCTATATCCAGTGTAAATGTTGATGAGCTTAGAGTGAGAAATGAGGAACGAATGCGAAGACTGAATGAATTTCACAATAAACCT
ATTAATACAGATGATGAGAGTTCACTGGTTGACCCTGATGACATCATGAAACACATAGGGGATGACGGATCAAACTCTGTAGCAACTGAG
CCCTGGCTCCGCCCTGGCACTTCAGAAACGCTGAAACGTTTCATGGCAGAGCAGCTGAACCAGGAGCAGCAGCAGATTCCTGGAAAACCA
GGCACTTTCACTTGGCAGGGCCTGTCGACTGCACATGGTTAAAATAAACCTGTACTGGACCCAGTAGTGCCTTTTAAGGTGAAAGGAATG
GTAAATCTGTACCTTTAATATGTCCTACTTTTGGCCCCTACCTGAAAGTTACTTTTTTTCCATCATCTGTATATAAAATTATTTTTATCA
TGATGTATATTATGTACATAAATAAAAGGCCATGATTATTGATTTATATAATAGAATTGTATAGATTATTTTTGCACAGTTTTGTCATAA
ATTAGGGTGGTAATGAACTGGATTGAACTACTATATGTGCATTATATTGAATTCTGCTTGTCATTAAGATAAGGTGAATAAGTGTCTTAA
ACGTCCTGTAAAACCGGACTCCCCTTTGTTACATGCACATTTTCCATTGTTACCTCGATGCAAAAGAATTCATTTAGTAGGTACATCTAT
TGTAGCTGTGATTATTCCAGTTTCTGTGTGATGCAATCAAATGTCCTATTAATTAATTATTATTTCATGTCATTTGTAGCTACTGATACA
GCAGAAATGAAGGGAACTGTAATTACTTGTATTTTTGTAAGCCATACGTTAAATGTTTGTTACATCATCTTTCTGCTTCTATTTTTATGC

>5851_5851_2_ARFGEF1-CSPP1_ARFGEF1_chr8_68150578_ENST00000262215_CSPP1_chr8_68024207_ENST00000412460_length(amino acids)=1893AA_BP=1095
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQS
KCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTN
DVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHEL
RSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQ
YVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLE
CNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAIRIACIF
SIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVRGREGSL
TGTKDQAPDEFVGLGLGGEDRELIQRRKEKYRLELLEQMAEQQRNKRREKDLELRVAASGAQDPEKSPDRLKQFSVAPRHFEEMIPPERP
RIAFQTPLPPLSAPSVPPIPSVHPVPSQNEDLRSGLSSALGEMVSPRIAPLPPPPLLPPLATNYRTPYDDAYYFYGSRNTFDPSLAYYGS
GMMGVQPAAYVSAPVTHQLAQPVVNTVGQNELKITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIREREERRKKEREEKEEYEAKLE
AEMRTYNPWGKGGGGAPLRDAKGNLISHMQTQSSPFARGNVFGEPPTELQIKQQELYKNFLRFQIEEKKQREEAERERLRIAEEKEERRL
AEQRARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIA
SKLQRPPSVDSIIRSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQLRSEERRLQERLLHMDSDDEIPIRKKERNPMDIF
DMARHRLQAPVRRQSPKGLDAATFQNVHDFNELKDRDSETRVDLKFMYLDPPRDHHTLEIQQQALLREQQKRLNRIKMQEGAKVDLDAIP
SAKVREQRMPRDDTSDFLKNSLLESDSAFIGAYGETYPAIEDDVLPPPSQLPSARERRRNKWKGLDIDSSRPNVAPDGLSLKSISSVNVD
ELRVRNEERMRRLNEFHNKPINTDDESSLVDPDDIMKHIGDDGSNSVATEPWLRPGTSETLKRFMAEQLNQEQQQIPGKPGTFTWQGLST

--------------------------------------------------------------
>5851_5851_3_ARFGEF1-CSPP1_ARFGEF1_chr8_68150578_ENST00000520381_CSPP1_chr8_68024207_ENST00000262210_length(transcript)=4935nt_BP=1719nt
AGGTGTTCTTTAAAGAAATTTTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGA
GGATTTGTGCAGATGCTCAGAGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAA
ATGATCTATCAAAAATTGCTCAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAG
AATGCTTAGTGTCGATTTTGAAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAA
AACCCTCAGAGCAAGAGATGAGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCAT
CAGGAATAGGCAGCTACAGTACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAAC
AAGGGATAGATTTATTTAATAAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTG
CCCAATTCTTACATCAAGAGGAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGT
ATGCATATGTGGACCAACATGACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAG
CTCAGAAAATCGATCGATTAATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAG
CTTATGTTTTGGCTTATTCAATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTA
AGATGAATAGAGGTATCAATGACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAA
TGAAAGAAACAAAAGAACTAACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAG
AAATGGAGCAGATGGCCAAGACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGC
ATGTGAGGCCCATGTTTAAGTTGGCTTGGACGCCTTTTCTGGCTGCATTCAGTGTGGGTCTACAAGATTGTGATGATACTGAAGTAGCCT
CTCTTTGCCTGGAAGGTATAAGATGTGCAATCAGAATTGCATGCATTTTCAGCATTCAGCTGGAGAGAGATGCATATGTCCAGGCACTAG
CAAGATTTACCTTACTCACAGTGAGTTCCGGTATTACTGAAATGAAACAGAAGAACATTGACACAATAAAAACACTTATCACAGTGGCTC
ATACAGATGGAAATTATTTAGGAAATTCATGGCATGAGATTCTGAAGTGCATCAGTCAGTTGGAGCTGGCACAGCTTATAGGAACTGGAG
TGAAACCTCGATACATTTCTGGAACAGTGCGAGGCAGAGAAGGATCTCTTACTGGAACAAAAGATCAGGCTCCTGATGAATTTGTGGGTT
TAGGGCTAGGAGGTGAAGATCGAGAACTTATTCAGAGAAGGAAAGAGAAATACAGACTAGAACTGTTGGAACAAATGGCTGAGCAACAGA
GGAACAAGAGACGAGAAAAAGATTTAGAACTCAGGGTTGCAGCGTCTGGAGCACAAGACCCTGAGAAATCGCCTGATAGACTAAAGCAGT
TTAGTGTGGCACCAAGACACTTTGAAGAGATGATACCACCTGAAAGACCCAGAATAGCTTTCCAGACACCTCTCCCTCCTTTATCTGCCC
CATCTGTCCCACCCATCCCATCAGTTCATCCTGTTCCTTCTCAAAATGAAGATTTGCGCAGTGGACTCAGCAGCGCCCTTGGTGAAATGG
TGTCTCCCAGGATTGCACCTCTGCCTCCACCTCCCCTACTACCACCTTTGGCTACTAACTATCGAACTCCTTATGATGATGCATACTATT
TTTATGGGTCCAGGAATACTTTCGATCCCAGTCTTGCTTATTATGGTTCAGGAATGATGGGCGTACAGCCTGCAGCTTATGTTAGTGCTC
CTGTCACCCACCAACTAGCACAACCTGTTGTGAATACGGTTGGACAGAATGAACTGAAGATTACAAGTGATCAAGTGATAAATTCAGGAT
TGATTTTTGAAGATAAACCGAAACCTTCCAAACAGTCACTTCAGTCTTACCAAGAGGCTTTGCAGCAGCAGATTCGGGAAAGAGAAGAAA
GAAGGAAGAAAGAACGTGAAGAAAAAGAAGAATATGAAGCTAAATTAGAAGCTGAAATGAGAACATATAATCCCTGGGGAAAAGGTGGAG
GTGGTGCTCCTCTCAGGGATGCAAAAGGAAATCTGATAACTGATTTGAATAGGATGCACAGACAAAATATAGATGCCTACCATAACCCAG
ATGCAAGAACATATGAAGATAAAAGGGCTGTTGTATCTCTAGACCCAAATTTAGCCACTTCAAATGCTGAGAACCTAGAAGATGCTGCAA
ATAAAAGCTCAGGTCATATGCAAACACAGAGCTCTCCTTTTGCTCGGGGAAATGTATTTGGTGAGCCTCCAACTGAACTTCAGATTAAAC
AGCAAGAATTATACAAGAATTTTCTTCGTTTCCAGATTGAGGAAAAGAAACAAAGAGAGGAAGCAGAGCGAGAGAGACTGAGAATTGCAG
AAGAAAAAGAAGAAAGACGGCTTGCAGAACAGAGGGCACGAATTCAGCAGGAGTATGAAGAGGAACAGGAAAAGAAAAGAGAGAAAGAGG
AGGAGCAAAGGCTAAAAAATGAAGAGCATATTCGGTTAGCTGAAGAAAGACAAAAAGAAGCAGAAAGAAAGAAGAAAGAAGAAGAAGAAA
AATATAACCTGCAACTTCAGCACTACTGTGAAAGAGACAATTTGATTGGGGAAGAAACAAAGCACATGAGACAGCCTTCTCCTATAGTTC
CTGCTCTTCAGAACAAAATTGCAAGCAAACTCCAAAGACCTCCTTCAGTTGACAGCATCATACGTTCCTTTATTCATGAAAGTTCCATGT
CCAGGGCACAGTCACCCCCGGTACCTGCCAGGAAAAATCAGCTCCGTGCAGAAGAGGAGAAAAAAAATGTAATTATGGAATTATCAGAAA
TGAGAAAACAGCTTCGTAGTGAAGAGAGGCGTCTACAAGAGCGATTGCTACACATGGACAGTGATGATGAAATTCCTATCAGGAAAAAGG
AAAGGAATCCCATGGATATATTTGATATGGCTAGACATCGGTTGCAAGCTCCTGTCAGAAGACAGTCCCCTAAGGGCTTAGACGCTGCCA
CTTTTCAGAATGTTCATGATTTTAATGAGCTGAAAGATAGAGATTCAGAAACACGAGTTGATCTGAAATTTATGTACCTGGATCCTCCAA
GAGATCATCACACCTTAGAGATTCAGCAGCAAGCCCTGCTAAGAGAGCAGCAGAAGAGGCTGAACAGAATAAAAATGCAGGAAGGTGCCA
AAGTTGACTTAGATGCCATCCCAAGTGCTAAAGTACGAGAGCAAAGAATGCCCAGAGATGACACTAGTGATTTCTTGAAAAACTCATTAT
TGGAATCTGATAGTGCTTTTATTGGGGCTTACGGTGAGACATATCCTGCCATTGAAGATGACGTCCTCCCTCCACCATCACAGTTGCCCT
CTGCACGGGAGCGCAGGAGGAACAAATGGAAAGGACTAGACATTGATAGCAGTCGTCCTAATGTAGCACCAGATGGTCTCTCTCTAAAAT
CTATATCCAGTGTAAATGTTGATGAGCTTAGAGTGAGAAATGAGGAACGAATGCGAAGACTGAATGAATTTCACAATAAACCTATTAATA
CAGATGATGAGAGTTCACTGGTTGACCCTGATGACATCATGAAACACATAGGGGATGACGGATCAAACTCTGTAGCAACTGAGCCCTGGC
TCCGCCCTGGCACTTCAGAAACGCTGAAACGTTTCATGGCAGAGCAGCTGAACCAGGAGCAGCAGCAGATTCCTGGAAAACCAGGCACTT
TCACTTGGCAGGGCCTGTCGACTGCACATGGTTAAAATAAACCTGTACTGGACCCAGTAGTGCCTTTTAAGGTGAAAGGAATGGTAAATC
TGTACCTTTAATATGTCCTACTTTTGGCCCCTACCTGAAAGTTACTTTTTTTCCATCATCTGTATATAAAATTATTTTTATCATGATGTA
TATTATGTACATAAATAAAAGGCCATGATTATTGATTTATATAATAGAATTGTATAGATTATTTTTGCACAGTTTTGTCATAAATTAGGG
TGGTAATGAACTGGATTGAACTACTATATGTGCATTATATTGAATTCTGCTTGTCATTAAGATAAGGTGAATAAGTGTCTTAAACGTCCT
GTAAAACCGGACTCCCCTTTGTTACATGCACATTTTCCATTGTTACCTCGATGCAAAAGAATTCATTTAGTAGGTACATCTATTGTAGCT
GTGATTATTCCAGTTTCTGTGTGATGCAATCAAATGTCCTATTAATTAATTATTATTTCATGTCATTTGTAGCTACTGATACAGCAGAAA
TGAAGGGAACTGTAATTACTTGTATTTTTGTAAGCCATACGTTAAATGTTTGTTACATCATCTTTCTGCTTCTATTTTTATGCCAATGAA

>5851_5851_3_ARFGEF1-CSPP1_ARFGEF1_chr8_68150578_ENST00000520381_CSPP1_chr8_68024207_ENST00000262210_length(amino acids)=1410AA_BP=561
METSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMV
EWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPK
RGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKF
AARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPT
KSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAI
RIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVR
GREGSLTGTKDQAPDEFVGLGLGGEDRELIQRRKEKYRLELLEQMAEQQRNKRREKDLELRVAASGAQDPEKSPDRLKQFSVAPRHFEEM
IPPERPRIAFQTPLPPLSAPSVPPIPSVHPVPSQNEDLRSGLSSALGEMVSPRIAPLPPPPLLPPLATNYRTPYDDAYYFYGSRNTFDPS
LAYYGSGMMGVQPAAYVSAPVTHQLAQPVVNTVGQNELKITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIREREERRKKEREEKEE
YEAKLEAEMRTYNPWGKGGGGAPLRDAKGNLITDLNRMHRQNIDAYHNPDARTYEDKRAVVSLDPNLATSNAENLEDAANKSSGHMQTQS
SPFARGNVFGEPPTELQIKQQELYKNFLRFQIEEKKQREEAERERLRIAEEKEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHI
RLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPALQNKIASKLQRPPSVDSIIRSFIHESSMSRAQSPPVPAR
KNQLRAEEEKKNVIMELSEMRKQLRSEERRLQERLLHMDSDDEIPIRKKERNPMDIFDMARHRLQAPVRRQSPKGLDAATFQNVHDFNEL
KDRDSETRVDLKFMYLDPPRDHHTLEIQQQALLREQQKRLNRIKMQEGAKVDLDAIPSAKVREQRMPRDDTSDFLKNSLLESDSAFIGAY
GETYPAIEDDVLPPPSQLPSARERRRNKWKGLDIDSSRPNVAPDGLSLKSISSVNVDELRVRNEERMRRLNEFHNKPINTDDESSLVDPD

--------------------------------------------------------------
>5851_5851_4_ARFGEF1-CSPP1_ARFGEF1_chr8_68150578_ENST00000520381_CSPP1_chr8_68024207_ENST00000412460_length(transcript)=4778nt_BP=1719nt
AGGTGTTCTTTAAAGAAATTTTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGA
GGATTTGTGCAGATGCTCAGAGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAA
ATGATCTATCAAAAATTGCTCAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAG
AATGCTTAGTGTCGATTTTGAAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAA
AACCCTCAGAGCAAGAGATGAGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCAT
CAGGAATAGGCAGCTACAGTACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAAC
AAGGGATAGATTTATTTAATAAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTG
CCCAATTCTTACATCAAGAGGAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGT
ATGCATATGTGGACCAACATGACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAG
CTCAGAAAATCGATCGATTAATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAG
CTTATGTTTTGGCTTATTCAATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTA
AGATGAATAGAGGTATCAATGACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAA
TGAAAGAAACAAAAGAACTAACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAG
AAATGGAGCAGATGGCCAAGACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGC
ATGTGAGGCCCATGTTTAAGTTGGCTTGGACGCCTTTTCTGGCTGCATTCAGTGTGGGTCTACAAGATTGTGATGATACTGAAGTAGCCT
CTCTTTGCCTGGAAGGTATAAGATGTGCAATCAGAATTGCATGCATTTTCAGCATTCAGCTGGAGAGAGATGCATATGTCCAGGCACTAG
CAAGATTTACCTTACTCACAGTGAGTTCCGGTATTACTGAAATGAAACAGAAGAACATTGACACAATAAAAACACTTATCACAGTGGCTC
ATACAGATGGAAATTATTTAGGAAATTCATGGCATGAGATTCTGAAGTGCATCAGTCAGTTGGAGCTGGCACAGCTTATAGGAACTGGAG
TGAAACCTCGATACATTTCTGGAACAGTGCGAGGCAGAGAAGGATCTCTTACTGGAACAAAAGATCAGGCTCCTGATGAATTTGTGGGTT
TAGGGCTAGGAGGTGAAGATCGAGAACTTATTCAGAGAAGGAAAGAGAAATACAGACTAGAACTGTTGGAACAAATGGCTGAGCAACAGA
GGAACAAGAGACGAGAAAAAGATTTAGAACTCAGGGTTGCAGCGTCTGGAGCACAAGACCCTGAGAAATCGCCTGATAGACTAAAGCAGT
TTAGTGTGGCACCAAGACACTTTGAAGAGATGATACCACCTGAAAGACCCAGAATAGCTTTCCAGACACCTCTCCCTCCTTTATCTGCCC
CATCTGTCCCACCCATCCCATCAGTTCATCCTGTTCCTTCTCAAAATGAAGATTTGCGCAGTGGACTCAGCAGCGCCCTTGGTGAAATGG
TGTCTCCCAGGATTGCACCTCTGCCTCCACCTCCCCTACTACCACCTTTGGCTACTAACTATCGAACTCCTTATGATGATGCATACTATT
TTTATGGGTCCAGGAATACTTTCGATCCCAGTCTTGCTTATTATGGTTCAGGAATGATGGGCGTACAGCCTGCAGCTTATGTTAGTGCTC
CTGTCACCCACCAACTAGCACAACCTGTTGTGAATACGGTTGGACAGAATGAACTGAAGATTACAAGTGATCAAGTGATAAATTCAGGAT
TGATTTTTGAAGATAAACCGAAACCTTCCAAACAGTCACTTCAGTCTTACCAAGAGGCTTTGCAGCAGCAGATTCGGGAAAGAGAAGAAA
GAAGGAAGAAAGAACGTGAAGAAAAAGAAGAATATGAAGCTAAATTAGAAGCTGAAATGAGAACATATAATCCCTGGGGAAAAGGTGGAG
GTGGTGCTCCTCTCAGGGATGCAAAAGGAAATCTGATAAGTCATATGCAAACACAGAGCTCTCCTTTTGCTCGGGGAAATGTATTTGGTG
AGCCTCCAACTGAACTTCAGATTAAACAGCAAGAATTATACAAGAATTTTCTTCGTTTCCAGATTGAGGAAAAGAAACAAAGAGAGGAAG
CAGAGCGAGAGAGACTGAGAATTGCAGAAGAAAAAGAAGAAAGACGGCTTGCAGAACAGAGGGCACGAATTCAGCAGGAGTATGAAGAGG
AACAGGAAAAGAAAAGAGAGAAAGAGGAGGAGCAAAGGCTAAAAAATGAAGAGCATATTCGGTTAGCTGAAGAAAGACAAAAAGAAGCAG
AAAGAAAGAAGAAAGAAGAAGAAGAAAAATATAACCTGCAACTTCAGCACTACTGTGAAAGAGACAATTTGATTGGGGAAGAAACAAAGC
ACATGAGACAGCCTTCTCCTATAGTTCCTGCTCTTCAGAACAAAATTGCAAGCAAACTCCAAAGACCTCCTTCAGTTGACAGCATCATAC
GTTCCTTTATTCATGAAAGTTCCATGTCCAGGGCACAGTCACCCCCGGTACCTGCCAGGAAAAATCAGCTCCGTGCAGAAGAGGAGAAAA
AAAATGTAATTATGGAATTATCAGAAATGAGAAAACAGCTTCGTAGTGAAGAGAGGCGTCTACAAGAGCGATTGCTACACATGGACAGTG
ATGATGAAATTCCTATCAGGAAAAAGGAAAGGAATCCCATGGATATATTTGATATGGCTAGACATCGGTTGCAAGCTCCTGTCAGAAGAC
AGTCCCCTAAGGGCTTAGACGCTGCCACTTTTCAGAATGTTCATGATTTTAATGAGCTGAAAGATAGAGATTCAGAAACACGAGTTGATC
TGAAATTTATGTACCTGGATCCTCCAAGAGATCATCACACCTTAGAGATTCAGCAGCAAGCCCTGCTAAGAGAGCAGCAGAAGAGGCTGA
ACAGAATAAAAATGCAGGAAGGTGCCAAAGTTGACTTAGATGCCATCCCAAGTGCTAAAGTACGAGAGCAAAGAATGCCCAGAGATGACA
CTAGTGATTTCTTGAAAAACTCATTATTGGAATCTGATAGTGCTTTTATTGGGGCTTACGGTGAGACATATCCTGCCATTGAAGATGACG
TCCTCCCTCCACCATCACAGTTGCCCTCTGCACGGGAGCGCAGGAGGAACAAATGGAAAGGACTAGACATTGATAGCAGTCGTCCTAATG
TAGCACCAGATGGTCTCTCTCTAAAATCTATATCCAGTGTAAATGTTGATGAGCTTAGAGTGAGAAATGAGGAACGAATGCGAAGACTGA
ATGAATTTCACAATAAACCTATTAATACAGATGATGAGAGTTCACTGGTTGACCCTGATGACATCATGAAACACATAGGGGATGACGGAT
CAAACTCTGTAGCAACTGAGCCCTGGCTCCGCCCTGGCACTTCAGAAACGCTGAAACGTTTCATGGCAGAGCAGCTGAACCAGGAGCAGC
AGCAGATTCCTGGAAAACCAGGCACTTTCACTTGGCAGGGCCTGTCGACTGCACATGGTTAAAATAAACCTGTACTGGACCCAGTAGTGC
CTTTTAAGGTGAAAGGAATGGTAAATCTGTACCTTTAATATGTCCTACTTTTGGCCCCTACCTGAAAGTTACTTTTTTTCCATCATCTGT
ATATAAAATTATTTTTATCATGATGTATATTATGTACATAAATAAAAGGCCATGATTATTGATTTATATAATAGAATTGTATAGATTATT
TTTGCACAGTTTTGTCATAAATTAGGGTGGTAATGAACTGGATTGAACTACTATATGTGCATTATATTGAATTCTGCTTGTCATTAAGAT
AAGGTGAATAAGTGTCTTAAACGTCCTGTAAAACCGGACTCCCCTTTGTTACATGCACATTTTCCATTGTTACCTCGATGCAAAAGAATT
CATTTAGTAGGTACATCTATTGTAGCTGTGATTATTCCAGTTTCTGTGTGATGCAATCAAATGTCCTATTAATTAATTATTATTTCATGT
CATTTGTAGCTACTGATACAGCAGAAATGAAGGGAACTGTAATTACTTGTATTTTTGTAAGCCATACGTTAAATGTTTGTTACATCATCT
TTCTGCTTCTATTTTTATGCCAATGAAGGCATTTGTCTTGTTACTAATTACATGATGTAACTACTTCTTGATATAAATAAATTTTTATTT

>5851_5851_4_ARFGEF1-CSPP1_ARFGEF1_chr8_68150578_ENST00000520381_CSPP1_chr8_68024207_ENST00000412460_length(amino acids)=1359AA_BP=561
METSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMV
EWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPK
RGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKF
AARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPT
KSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKLAWTPFLAAFSVGLQDCDDTEVASLCLEGIRCAI
RIACIFSIQLERDAYVQALARFTLLTVSSGITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKPRYISGTVR
GREGSLTGTKDQAPDEFVGLGLGGEDRELIQRRKEKYRLELLEQMAEQQRNKRREKDLELRVAASGAQDPEKSPDRLKQFSVAPRHFEEM
IPPERPRIAFQTPLPPLSAPSVPPIPSVHPVPSQNEDLRSGLSSALGEMVSPRIAPLPPPPLLPPLATNYRTPYDDAYYFYGSRNTFDPS
LAYYGSGMMGVQPAAYVSAPVTHQLAQPVVNTVGQNELKITSDQVINSGLIFEDKPKPSKQSLQSYQEALQQQIREREERRKKEREEKEE
YEAKLEAEMRTYNPWGKGGGGAPLRDAKGNLISHMQTQSSPFARGNVFGEPPTELQIKQQELYKNFLRFQIEEKKQREEAERERLRIAEE
KEERRLAEQRARIQQEYEEEQEKKREKEEEQRLKNEEHIRLAEERQKEAERKKKEEEEKYNLQLQHYCERDNLIGEETKHMRQPSPIVPA
LQNKIASKLQRPPSVDSIIRSFIHESSMSRAQSPPVPARKNQLRAEEEKKNVIMELSEMRKQLRSEERRLQERLLHMDSDDEIPIRKKER
NPMDIFDMARHRLQAPVRRQSPKGLDAATFQNVHDFNELKDRDSETRVDLKFMYLDPPRDHHTLEIQQQALLREQQKRLNRIKMQEGAKV
DLDAIPSAKVREQRMPRDDTSDFLKNSLLESDSAFIGAYGETYPAIEDDVLPPPSQLPSARERRRNKWKGLDIDSSRPNVAPDGLSLKSI
SSVNVDELRVRNEERMRRLNEFHNKPINTDDESSLVDPDDIMKHIGDDGSNSVATEPWLRPGTSETLKRFMAEQLNQEQQQIPGKPGTFT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARFGEF1-CSPP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ARFGEF1-CSPP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ARFGEF1-CSPP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource