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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NELL1-SMCO4 (FusionGDB2 ID:58570)

Fusion Gene Summary for NELL1-SMCO4

Fusion gene summary

Fusion gene information	Fusion gene name: NELL1-SMCO4
	Fusion gene ID: 58570
		Hgene	Tgene
	Gene symbol	NELL1	SMCO4
	Gene ID	4745	56935
	Gene name	neural EGFL like 1	single-pass membrane protein with coiled-coil domains 4
	Synonyms	IDH3GL\|NRP1	C11orf75\|FN5
	Cytomap	11p15.1	11q21
	Type of gene	protein-coding	protein-coding
	Description	protein kinase C-binding protein NELL1nel-related protein 1neural epidermal growth factor-like 1	single-pass membrane and coiled-coil domain-containing protein 4UPF0443 protein C11orf75
	Modification date	20200313	20200313
	UniProtAcc	Q92832	Q9NRQ5
	Ensembl transtripts involved in fusion gene	ENST00000298925, ENST00000325319, ENST00000357134, ENST00000532434, ENST00000529218,	ENST00000298966, ENST00000527149, ENST00000525141,
Fusion gene scores	* DoF score	12 X 12 X 3=432	5 X 3 X 4=60
	# samples	12	5
	** MAII score	log2(12/432*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NELL1 [Title/Abstract] AND SMCO4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NELL1(20907086)-SMCO4(93232514), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NELL1	GO:0010468	regulation of gene expression	21723284
Hgene	NELL1	GO:0030501	positive regulation of bone mineralization	21723284
Hgene	NELL1	GO:0033689	negative regulation of osteoblast proliferation	21723284
Hgene	NELL1	GO:0045669	positive regulation of osteoblast differentiation	21723284
Hgene	NELL1	GO:1903363	negative regulation of cellular protein catabolic process	21723284

Fusion gene breakpoints across NELL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SMCO4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-ER-A19H-06A	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-

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Fusion Gene ORF analysis for NELL1-SMCO4

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000298925	ENST00000298966	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
5CDS-5UTR	ENST00000298925	ENST00000527149	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
5CDS-5UTR	ENST00000325319	ENST00000298966	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
5CDS-5UTR	ENST00000325319	ENST00000527149	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
5CDS-5UTR	ENST00000357134	ENST00000298966	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
5CDS-5UTR	ENST00000357134	ENST00000527149	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
5CDS-5UTR	ENST00000532434	ENST00000298966	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
5CDS-5UTR	ENST00000532434	ENST00000527149	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
In-frame	ENST00000298925	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
In-frame	ENST00000325319	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
In-frame	ENST00000357134	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
In-frame	ENST00000532434	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
intron-3CDS	ENST00000529218	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
intron-5UTR	ENST00000529218	ENST00000298966	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-
intron-5UTR	ENST00000529218	ENST00000527149	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000298925	NELL1	chr11	20907086	+	ENST00000525141	SMCO4	chr11	93232514	-	1729	840	153	848	231
ENST00000357134	NELL1	chr11	20907086	+	ENST00000525141	SMCO4	chr11	93232514	-	1644	755	152	763	203
ENST00000325319	NELL1	chr11	20907086	+	ENST00000525141	SMCO4	chr11	93232514	-	1462	573	533	1063	176
ENST00000532434	NELL1	chr11	20907086	+	ENST00000525141	SMCO4	chr11	93232514	-	1555	666	63	674	203

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000298925	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-	0.008369508	0.9916305
ENST00000357134	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-	0.004434435	0.9955656
ENST00000325319	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-	0.5853628	0.41463727
ENST00000532434	ENST00000525141	NELL1	chr11	20907086	+	SMCO4	chr11	93232514	-	0.004338557	0.99566144

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Fusion Genomic Features for NELL1-SMCO4

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NELL1-SMCO4

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:20907086/chr11:93232514)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NELL1 Q92832	SMCO4 Q9NRQ5
FUNCTION: Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization. {ECO:0000269\|PubMed:21723284}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SMCO4

chr11:20907086

chr11:93232514

ENST00000298966

9_31

60.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMCO4

chr11:20907086

chr11:93232514

ENST00000525141

-1

9_31

60.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMCO4

chr11:20907086

chr11:93232514

ENST00000527149

9_31

60.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SMCO4

chr11:20907086

chr11:93232514

ENST00000298966

32_52

60.0

Transmembrane

Helical

Tgene

SMCO4

chr11:20907086

chr11:93232514

ENST00000525141

-1

32_52

60.0

Transmembrane

Helical

Tgene

SMCO4

chr11:20907086

chr11:93232514

ENST00000527149

32_52

60.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000357134

271_332

201

811.0

Domain

VWFC 1

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000357134

434_475

201

811.0

Domain

EGF-like 1%3B calcium-binding

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000357134

476_516

201

811.0

Domain

EGF-like 2%3B calcium-binding

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000357134

517_547

201

811.0

Domain

EGF-like 3

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000357134

549_587

201

811.0

Domain

EGF-like 4%3B calcium-binding

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000357134

596_631

201

811.0

Domain

EGF-like 5%3B calcium-binding

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000357134

64_227

201

811.0

Domain

Note=Laminin G-like

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000357134

692_750

201

811.0

Domain

VWFC 2

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000532434

271_332

201

764.0

Domain

VWFC 1

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000532434

434_475

201

764.0

Domain

EGF-like 1%3B calcium-binding

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000532434

476_516

201

764.0

Domain

EGF-like 2%3B calcium-binding

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000532434

517_547

201

764.0

Domain

EGF-like 3

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000532434

549_587

201

764.0

Domain

EGF-like 4%3B calcium-binding

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000532434

596_631

201

764.0

Domain

EGF-like 5%3B calcium-binding

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000532434

64_227

201

764.0

Domain

Note=Laminin G-like

Hgene

NELL1

chr11:20907086

chr11:93232514

ENST00000532434

692_750

201

764.0

Domain

VWFC 2

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Fusion Gene Sequence for NELL1-SMCO4

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>58570_58570_1_NELL1-SMCO4_NELL1_chr11_20907086_ENST00000298925_SMCO4_chr11_93232514_ENST00000525141_length(transcript)=1729nt_BP=840nt
ATATGCGAGCGCAGCACCCGGCGCTGCCGAGCCACCTCCCCCGCCGCCCGCTAGCAAGTTTGGCGGCTCCAAGCCAGGCGCGCCTCAGGA
TCCAGGCTCATTTGCTTCCACCTAGCTTCGGTGCCCCCTGCTAGGCGGGGACCCTCGAGAGCGATGCCGATGGATTTGATTTTAGTTGTG
TGGTTCTGTGTGTGCACTGCCAGGACAGCAGAAGATATGAAGCCACCCGTGTTATCGCTGATATGGAGAACTAGAGTTCTGAAGTCTCTG
CTTCAGCAATCCCTTCAGGGAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATCGTCACCGAGCTTGACCTTGTGAACACC
ACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGACATAGAAAGAGAGATCCATGCAGCTCCT
CATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACTGTACAGCAGAAGCCATCCACTTCAGGA
GTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGCCTGAGGGATGAGATTCGGTATCACTACATACAC
AATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCACAAGGTTGCACTGTCAGTTAGCGCCTCTCATCTC
CTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTTCCCCCAGGAATCAATTTATGGCTTGGC
CAGCGCAACCAAAAGCATGGCTTATTCAAACAGGAATAACTCAAGTCACCTGTACTGGAAATCAGTTTGCTGAAATTAATCAACGATTCT
TGAAGTTGAAGAAAAGTTGTTCTCTCTACAGGAGGTTCCAGCCTTGGCAAGAGGAGTGTGGCCCTTCCTGGAATCCCTCTGGACACACCC
TCCTAGCATCCTCTAGGAAAGATGCGGCAGCTCAAAGGGAAGCCCAAGAAGGAGACCTCCAAGGACAAGAAGGAGCGGAAGCAAGCCATG
CAGGAGGCCCGGCAGCAGATCACTACAGTGGTGCTGCCCACGCTGGCCGTGGTCGTGCTCTTGATCGTGGTGTTTGTGTACGTGGCCACG
CGCCCCACCATCACCGAGTGAGCCCCGCAGCCGGCTGCGGACCCCATCGGCAGGGAGAGGAGGCGCGGGAGGGGGACGCAAACAAAAAAT
GGCTTTCATATTCAGAGATGTTCATGTTGCTGAGCTGTAAGCAGGAGCACCCTGTCTTCTCTGGTCTTTGACTTGATTAAAGTATCTCCG
CTTTCTTGGGAGGGAATAGGGGATGTTTTATCAGTGAATGTGCCATACACCTTATGGTCCACTTCATGTGCCTTTCAGACTTCAAAGCGC
GCGCGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTTCTTTTTCTCTCCTAAAAATCGATAAGTAGCTCCACCTGAA
GAGGGATGGAACCTCTGGGTCAGGAAACAGCTGGAATCCACACTCACCTCATTCCCATTGTTTGGATCATGCTTCTTTCCAACACGTGTT
CACAATCTCCAAAGGGACTGTATTTCTTCTCTGTGCTTAATGTGATTTGAAATATGTTGAATCAAAGTGAAATATTTATTTTTTGAATAA

>58570_58570_1_NELL1-SMCO4_NELL1_chr11_20907086_ENST00000298925_SMCO4_chr11_93232514_ENST00000525141_length(amino acids)=231AA_BP=
MPMDLILVVWFCVCTARTAEDMKPPVLSLIWRTRVLKSLLQQSLQGVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQD
IEREIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKV

--------------------------------------------------------------
>58570_58570_2_NELL1-SMCO4_NELL1_chr11_20907086_ENST00000325319_SMCO4_chr11_93232514_ENST00000525141_length(transcript)=1462nt_BP=573nt
AGCACCCGGCGCTGCCGAGCCACCTCCCCCGCCGCCCGCTAGCAAGTTTGGCGGCTCCAAGCCAGGCGCGCCTCAGGATCCAGGCTCATT
TGCTTCCACCTAGCTTCGGTGCCCCCTGCTAGGCGGGGACCCTCGAGAGCGATGCCGATGGATTTGATTTTAGTTGTGTGGTTCTGTGTG
TGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATCGTCACCGAGCTTGACCTTGTGAACACCACCCTT
GGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGACATAGAAAGAGAGATCCATGCAGCTCCTCATGTG
AGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACTGTACAGCAGAAGCCATCCACTTCAGGAGTGATA
CTGTCCATTCGAGAACTGGAGCACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTTCCCCCAGGAATCAATTTATGGCTT
GGCCAGCGCAACCAAAAGCATGGCTTATTCAAACAGGAATAACTCAAGTCACCTGTACTGGAAATCAGTTTGCTGAAATTAATCAACGAT
TCTTGAAGTTGAAGAAAAGTTGTTCTCTCTACAGGAGGTTCCAGCCTTGGCAAGAGGAGTGTGGCCCTTCCTGGAATCCCTCTGGACACA
CCCTCCTAGCATCCTCTAGGAAAGATGCGGCAGCTCAAAGGGAAGCCCAAGAAGGAGACCTCCAAGGACAAGAAGGAGCGGAAGCAAGCC
ATGCAGGAGGCCCGGCAGCAGATCACTACAGTGGTGCTGCCCACGCTGGCCGTGGTCGTGCTCTTGATCGTGGTGTTTGTGTACGTGGCC
ACGCGCCCCACCATCACCGAGTGAGCCCCGCAGCCGGCTGCGGACCCCATCGGCAGGGAGAGGAGGCGCGGGAGGGGGACGCAAACAAAA
AATGGCTTTCATATTCAGAGATGTTCATGTTGCTGAGCTGTAAGCAGGAGCACCCTGTCTTCTCTGGTCTTTGACTTGATTAAAGTATCT
CCGCTTTCTTGGGAGGGAATAGGGGATGTTTTATCAGTGAATGTGCCATACACCTTATGGTCCACTTCATGTGCCTTTCAGACTTCAAAG
CGCGCGCGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTTCTTTTTCTCTCCTAAAAATCGATAAGTAGCTCCACCT
GAAGAGGGATGGAACCTCTGGGTCAGGAAACAGCTGGAATCCACACTCACCTCATTCCCATTGTTTGGATCATGCTTCTTTCCAACACGT
GTTCACAATCTCCAAAGGGACTGTATTTCTTCTCTGTGCTTAATGTGATTTGAAATATGTTGAATCAAAGTGAAATATTTATTTTTTGAA

>58570_58570_2_NELL1-SMCO4_NELL1_chr11_20907086_ENST00000325319_SMCO4_chr11_93232514_ENST00000525141_length(amino acids)=176AA_BP=13
MAWPAQPKAWLIQTGITQVTCTGNQFAEINQRFLKLKKSCSLYRRFQPWQEECGPSWNPSGHTLLASSRKDAAAQREAQEGDLQGQEGAE

--------------------------------------------------------------
>58570_58570_3_NELL1-SMCO4_NELL1_chr11_20907086_ENST00000357134_SMCO4_chr11_93232514_ENST00000525141_length(transcript)=1644nt_BP=755nt
TATGCGAGCGCAGCACCCGGCGCTGCCGAGCCACCTCCCCCGCCGCCCGCTAGCAAGTTTGGCGGCTCCAAGCCAGGCGCGCCTCAGGAT
CCAGGCTCATTTGCTTCCACCTAGCTTCGGTGCCCCCTGCTAGGCGGGGACCCTCGAGAGCGATGCCGATGGATTTGATTTTAGTTGTGT
GGTTCTGTGTGTGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATCGTCACCGAGCTTGACCTTGTGA
ACACCACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGACATAGAAAGAGAGATCCATGCAG
CTCCTCATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACTGTACAGCAGAAGCCATCCACTT
CAGGAGTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGCCTGAGGGATGAGATTCGGTATCACTACA
TACACAATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCACAAGGTTGCACTGTCAGTTAGCGCCTCTC
ATCTCCTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTTCCCCCAGGAATCAATTTATGGC
TTGGCCAGCGCAACCAAAAGCATGGCTTATTCAAACAGGAATAACTCAAGTCACCTGTACTGGAAATCAGTTTGCTGAAATTAATCAACG
ATTCTTGAAGTTGAAGAAAAGTTGTTCTCTCTACAGGAGGTTCCAGCCTTGGCAAGAGGAGTGTGGCCCTTCCTGGAATCCCTCTGGACA
CACCCTCCTAGCATCCTCTAGGAAAGATGCGGCAGCTCAAAGGGAAGCCCAAGAAGGAGACCTCCAAGGACAAGAAGGAGCGGAAGCAAG
CCATGCAGGAGGCCCGGCAGCAGATCACTACAGTGGTGCTGCCCACGCTGGCCGTGGTCGTGCTCTTGATCGTGGTGTTTGTGTACGTGG
CCACGCGCCCCACCATCACCGAGTGAGCCCCGCAGCCGGCTGCGGACCCCATCGGCAGGGAGAGGAGGCGCGGGAGGGGGACGCAAACAA
AAAATGGCTTTCATATTCAGAGATGTTCATGTTGCTGAGCTGTAAGCAGGAGCACCCTGTCTTCTCTGGTCTTTGACTTGATTAAAGTAT
CTCCGCTTTCTTGGGAGGGAATAGGGGATGTTTTATCAGTGAATGTGCCATACACCTTATGGTCCACTTCATGTGCCTTTCAGACTTCAA
AGCGCGCGCGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTTCTTTTTCTCTCCTAAAAATCGATAAGTAGCTCCAC
CTGAAGAGGGATGGAACCTCTGGGTCAGGAAACAGCTGGAATCCACACTCACCTCATTCCCATTGTTTGGATCATGCTTCTTTCCAACAC
GTGTTCACAATCTCCAAAGGGACTGTATTTCTTCTCTGTGCTTAATGTGATTTGAAATATGTTGAATCAAAGTGAAATATTTATTTTTTG

>58570_58570_3_NELL1-SMCO4_NELL1_chr11_20907086_ENST00000357134_SMCO4_chr11_93232514_ENST00000525141_length(amino acids)=203AA_BP=
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTIL
ATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT

--------------------------------------------------------------
>58570_58570_4_NELL1-SMCO4_NELL1_chr11_20907086_ENST00000532434_SMCO4_chr11_93232514_ENST00000525141_length(transcript)=1555nt_BP=666nt
TCCAGGCTCATTTGCTTCCACCTAGCTTCGGTGCCCCCTGCTAGGCGGGGACCCTCGAGAGCGATGCCGATGGATTTGATTTTAGTTGTG
TGGTTCTGTGTGTGCACTGCCAGGACAGTGGTGGGCTTTGGGATGGACCCTGACCTTCAGATGGATATCGTCACCGAGCTTGACCTTGTG
AACACCACCCTTGGAGTTGCTCAGGTGTCTGGAATGCACAATGCCAGCAAAGCATTTTTATTTCAAGACATAGAAAGAGAGATCCATGCA
GCTCCTCATGTGAGTGAGAAATTAATTCAGCTGTTCCGGAACAAGAGTGAATTCACCATTTTGGCCACTGTACAGCAGAAGCCATCCACT
TCAGGAGTGATACTGTCCATTCGAGAACTGGAGCACAGCTATTTTGAACTGGAGAGCAGTGGCCTGAGGGATGAGATTCGGTATCACTAC
ATACACAATGGGAAGCCAAGGACAGAGGCACTTCCTTACCGCATGGCAGATGGACAATGGCACAAGGTTGCACTGTCAGTTAGCGCCTCT
CATCTCCTGCTCCATGTCGACTGTAACAGGATTTATGAGCGTGTGATAGACCCTCCAGATACCAACCTTCCCCCAGGAATCAATTTATGG
CTTGGCCAGCGCAACCAAAAGCATGGCTTATTCAAACAGGAATAACTCAAGTCACCTGTACTGGAAATCAGTTTGCTGAAATTAATCAAC
GATTCTTGAAGTTGAAGAAAAGTTGTTCTCTCTACAGGAGGTTCCAGCCTTGGCAAGAGGAGTGTGGCCCTTCCTGGAATCCCTCTGGAC
ACACCCTCCTAGCATCCTCTAGGAAAGATGCGGCAGCTCAAAGGGAAGCCCAAGAAGGAGACCTCCAAGGACAAGAAGGAGCGGAAGCAA
GCCATGCAGGAGGCCCGGCAGCAGATCACTACAGTGGTGCTGCCCACGCTGGCCGTGGTCGTGCTCTTGATCGTGGTGTTTGTGTACGTG
GCCACGCGCCCCACCATCACCGAGTGAGCCCCGCAGCCGGCTGCGGACCCCATCGGCAGGGAGAGGAGGCGCGGGAGGGGGACGCAAACA
AAAAATGGCTTTCATATTCAGAGATGTTCATGTTGCTGAGCTGTAAGCAGGAGCACCCTGTCTTCTCTGGTCTTTGACTTGATTAAAGTA
TCTCCGCTTTCTTGGGAGGGAATAGGGGATGTTTTATCAGTGAATGTGCCATACACCTTATGGTCCACTTCATGTGCCTTTCAGACTTCA
AAGCGCGCGCGCATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGCTTCTTTTTCTCTCCTAAAAATCGATAAGTAGCTCCA
CCTGAAGAGGGATGGAACCTCTGGGTCAGGAAACAGCTGGAATCCACACTCACCTCATTCCCATTGTTTGGATCATGCTTCTTTCCAACA
CGTGTTCACAATCTCCAAAGGGACTGTATTTCTTCTCTGTGCTTAATGTGATTTGAAATATGTTGAATCAAAGTGAAATATTTATTTTTT

>58570_58570_4_NELL1-SMCO4_NELL1_chr11_20907086_ENST00000532434_SMCO4_chr11_93232514_ENST00000525141_length(amino acids)=203AA_BP=
MPMDLILVVWFCVCTARTVVGFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIEREIHAAPHVSEKLIQLFRNKSEFTIL
ATVQQKPSTSGVILSIRELEHSYFELESSGLRDEIRYHYIHNGKPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDT

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Fusion Gene PPI Analysis for NELL1-SMCO4

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for NELL1-SMCO4

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for NELL1-SMCO4

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source