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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARFGEF1-PPP1R42 (FusionGDB2 ID:5859)

Fusion Gene Summary for ARFGEF1-PPP1R42

Fusion gene summary

Fusion gene information	Fusion gene name: ARFGEF1-PPP1R42
	Fusion gene ID: 5859
		Hgene	Tgene
	Gene symbol	ARFGEF1	PPP1R42
	Gene ID	10565	286187
	Gene name	ADP ribosylation factor guanine nucleotide exchange factor 1	protein phosphatase 1 regulatory subunit 42
	Synonyms	ARFGEP1\|BIG1\|P200	LRRC67\|TLLR\|TLRR\|dtr
	Cytomap	8q13.2	8q13.1
	Type of gene	protein-coding	protein-coding
	Description	brefeldin A-inhibited guanine nucleotide-exchange protein 1ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)p200 ARF guanine nucleotide exchange factor	protein phosphatase 1 regulatory subunit 42leucine rich repeat containing 67leucine-rich repeat-containing protein 67testis leucine-rich repeat
	Modification date	20200313	20200320
	UniProtAcc	Q9Y6D6	.
	Ensembl transtripts involved in fusion gene	ENST00000262215, ENST00000520381, ENST00000517955, ENST00000518230,	ENST00000517834, ENST00000324682, ENST00000522909,
Fusion gene scores	* DoF score	14 X 14 X 6=1176	4 X 4 X 4=64
	# samples	17	5
	** MAII score	log2(17/1176*10)=-2.79028140869866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ARFGEF1 [Title/Abstract] AND PPP1R42 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARFGEF1(68163534)-PPP1R42(67926827), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARFGEF1	GO:0034260	negative regulation of GTPase activity	15644318

Fusion gene breakpoints across ARFGEF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP1R42 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N8-A4PI-01A	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-

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Fusion Gene ORF analysis for ARFGEF1-PPP1R42

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000262215	ENST00000517834	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
5CDS-intron	ENST00000520381	ENST00000517834	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
In-frame	ENST00000262215	ENST00000324682	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
In-frame	ENST00000262215	ENST00000522909	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
In-frame	ENST00000520381	ENST00000324682	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
In-frame	ENST00000520381	ENST00000522909	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
intron-3CDS	ENST00000517955	ENST00000324682	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
intron-3CDS	ENST00000517955	ENST00000522909	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
intron-3CDS	ENST00000518230	ENST00000324682	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
intron-3CDS	ENST00000518230	ENST00000522909	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
intron-intron	ENST00000517955	ENST00000517834	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-
intron-intron	ENST00000518230	ENST00000517834	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000520381	ARFGEF1	chr8	68163534	-	ENST00000522909	PPP1R42	chr8	67926827	-	2248	1280	32	2080	682
ENST00000520381	ARFGEF1	chr8	68163534	-	ENST00000324682	PPP1R42	chr8	67926827	-	2090	1280	32	1837	601
ENST00000262215	ARFGEF1	chr8	68163534	-	ENST00000522909	PPP1R42	chr8	67926827	-	4208	3240	390	4040	1216
ENST00000262215	ARFGEF1	chr8	68163534	-	ENST00000324682	PPP1R42	chr8	67926827	-	4050	3240	390	3797	1135

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000520381	ENST00000522909	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-	0.001228792	0.99877113
ENST00000520381	ENST00000324682	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-	0.00060458	0.9993954
ENST00000262215	ENST00000522909	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-	0.00055136	0.9994486
ENST00000262215	ENST00000324682	ARFGEF1	chr8	68163534	-	PPP1R42	chr8	67926827	-	0.000312207	0.9996878

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Fusion Genomic Features for ARFGEF1-PPP1R42

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARFGEF1-PPP1R42

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:68163534/chr8:67926827)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARFGEF1 Q9Y6D6	.
FUNCTION: Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined. {ECO:0000269\|PubMed:12571360, ECO:0000269\|PubMed:15644318, ECO:0000269\|PubMed:17227842, ECO:0000269\|PubMed:20360857, ECO:0000269\|PubMed:22084092}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARFGEF1

chr8:68163534

chr8:67926827

ENST00000262215

709_840

950

1850.0

Domain

SEC7

Hgene

ARFGEF1

chr8:68163534

chr8:67926827

ENST00000262215

711_715

950

1850.0

Motif

Note=Nuclear localization signal (NLS)

Tgene

PPP1R42

chr8:68163534

chr8:67926827

ENST00000324682

204_242

229.0

Domain

Note=LRRCT

Tgene

PPP1R42

chr8:68163534

chr8:67926827

ENST00000324682

117_138

229.0

Repeat

Note=LRR 5

Tgene

PPP1R42

chr8:68163534

chr8:67926827

ENST00000324682

147_168

229.0

Repeat

Note=LRR 6

Tgene

PPP1R42

chr8:68163534

chr8:67926827

ENST00000324682

169_190

229.0

Repeat

Note=LRR 7

Tgene

PPP1R42

chr8:68163534

chr8:67926827

ENST00000324682

51_72

229.0

Repeat

Note=LRR 2

Tgene

PPP1R42

chr8:68163534

chr8:67926827

ENST00000324682

73_94

229.0

Repeat

Note=LRR 3

Tgene

PPP1R42

chr8:68163534

chr8:67926827

ENST00000324682

95_116

229.0

Repeat

Note=LRR 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PPP1R42

chr8:68163534

chr8:67926827

ENST00000324682

29_50

229.0

Repeat

Note=LRR 1

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Fusion Gene Sequence for ARFGEF1-PPP1R42

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5859_5859_1_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000262215_PPP1R42_chr8_67926827_ENST00000324682_length(transcript)=4050nt_BP=3240nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGAGGAAATAAAAGCGGAAACTGAAAAA
CAGAGTCCTCCTCATGGAGAAGCAAAAGCTGGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTAGATTGCTTACAGAAACTTATTGCTTATGGG
CACTTGACTGGCAATGCTCCAGATAGTACAACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGCTTTACTTACTGCAGTAACATCACAACACATAGAAATTCATGAAGGGACT
GTACTGCAAGCTGTGAGAACATGTTACAATATCTACTTAGCAAGCAAAAATCTCATCAATCAGACAACAGCCAAAGCTACTCTCACTCAG
ATGCTAAATGTTATCTTTGCACGCATGGAAAACCAAGCATTACAGGAAGCAAAACAAATGGAAAAAGAAAGGCATCGGCAGCATCATCAT
CTGTTACAGTCTCCAGTAAGCCATCACGAGCCTGAATCACCTCAACTTAGATATTTGCCACCTCAGACTGTTGATCATATATCCCAAGAA
CACGAAGGGGACCTTGACCTCCATACAAATGATGTAGATAAAAGTCTTCAGGATGACACAGAGCCTGAAAATGGATCTGATATTTCCAGT
GCAGAAAATGAACAGACTGAAGCTGATCAGGCAACTGCAGCTGAAACATTATCTAAAAATGAAGTGTTATATGACGGAGAAAACCATGAT
TGTGAGGAAAAGCCACAAGACATTGTACAGAACATTGTAGAAGAAATGGTGAACATTGTTGTTGGAGATATGGGAGAAGGGACTACTATA
AATGCAAGTGCAGATGGCAACATTGGAACTATAGAGGATGGTAGTGACAGTGAAAATATTCAAGCAAATGGAATTCCAGGAACACCAATT
TCTGTTGCATATACACCATCCTTACCTGATGATAGATTGTCAGTCTCTTCCAATGATACTCAGGAATCTGGAAATTCTTCAGGACCTTCA
CCTGGTGCTAAGTTTTCCCACATTTTACAAAAGGATGCCTTTCTAGTATTCAGGTCATTGTGTAAACTGTCAATGAAACCACTGTCAGAT
GGACCACCAGATCCAAAGTCTCATGAACTACGATCCAAGATTCTTTCATTGCAGTTACTTCTATCCATTCTGCAGAATGCAGGACCTATT
TTCAGGACAAATGAGATGTTTATTAATGCTATTAAGCAGTATCTTTGTGTTGCACTCTCAAAAAATGGAGTCTCATCTGTTCCAGAGGTT
TTTGAGCTTTCTCTTTCTATATTTCTTACTTTGTTGTCAAATTTCAAGACACATCTGAAGATGCAAATTGAGGTGTTCTTTAAAGAAATT
TTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGAGGATTTGTGCAGATGCTCAG
AGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAAATGATCTATCAAAAATTGCT
CAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAGAATGCTTAGTGTCGATTTTG
AAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAAAACCCTCAGAGCAAGAGATG
AGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCATCAGGAATAGGCAGCTACAGT
ACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAACAAGGGATAGATTTATTTAAT
AAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTGCCCAATTCTTACATCAAGAG
GAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGTATGCATATGTGGACCAACAT
GACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAGCTCAGAAAATCGATCGATTA
ATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAGCTTATGTTTTGGCTTATTCA
ATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTAAGATGAATAGAGGTATCAAT
GACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAATGAAAGAAACAAAAGAACTA
ACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAGAAATGGAGCAGATGGCCAAG
ACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGCATGTGAGGCCCATGTTTAAG
GAAGACCTCTCTCTTTGCAAAAATCTTAGTGTTTTATATTTATATGATAATTGTATTAGTCAAATCACTAACCTGAATTATGCCACAAAT
CTGACCCACTTGTACCTACAAAACAATTGTATTTCATGTATAGAGAACCTCAGGTCATTAAAGAAACTGGAAAAACTGTATCTGGGAGGC
AATTACATTGCTGTCATAGAAGGTTTAGAAGGATTAGGAGAACTAAGAGAGCTTCATGTTGAGAATCAGAGGCTTCCCCTTGGGGAAAAG
CTTCTGTTTGATCCAAGAACTCTTCATTCTCTGGCAAAATCCCTCTGTATATTGAATATCAGCAATAATAATATTGATGACATTACAGAC
TTAGAACTACTAGAGAATCTTAATCAGCTCATAGCCGTTGACAACCAACTTCTGCATGTGAAGGATTTGGAGTTTTTACTGAACAAGTTG
ATGAAGCTGTGGAAAATTGATCTAAATGGAAATCCTGTTTGTCTCAAACCAAAATACAGGGACAGACTGATATTGGTGTCCAAATCACTG
GGTACATATTTATATTAATATAATTTTTAAGAGAATGACACCTAGTTAACTTTTTGGTTATTTTACCAGCAAGCTTTCAGAAATATAAAT
CTGACATCTGGATCTGTGAAAATTGTCAACTTTAAATTCAATATTTTGAATAAGAGCAAAAGTTAAAATTGACAAATAAAGCATGAAAAA
CATCTGCTGTTCAGAAGTAATTAAAGCACCTGATACTTATTCCTTAAGGAGGATATTTTGCTATTACCAATAAAAATGGTTAGTCATAAA

>5859_5859_1_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000262215_PPP1R42_chr8_67926827_ENST00000324682_length(amino acids)=1135AA_BP=0
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQS
KCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTN
DVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHEL
RSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQ
YVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLE
CNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNC
ISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQL

--------------------------------------------------------------
>5859_5859_2_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000262215_PPP1R42_chr8_67926827_ENST00000522909_length(transcript)=4208nt_BP=3240nt
GCGGTGCCTCTGAGAGCCGCCGCCACCTCGTCCCTCAGTTCCCGGCAGACAGCCGCCCGGGCCGGGCTCCCTCACCGCCACCAGGGCCGG
AGGGACGAGTGAGAGGGGCGGCCGGGACGCGACCCCCGGGCCGGGAGAAGCGGAGGCCCGACGGGCGCGGCCCTCGAGGTACGGCTTCTT
GGGGGCGGCGAGGACCTCGACGCCCTTCGCCGACACCGCGGCTGGTCCCGCTCGCCCGCCCCTTCCTGATCCTGCCGCTGCCCTCCACGC
CTCCAATCCCCCACCTCCACCCCCTCTCCTTTCTCTCTTCTCTTCCTTCCTCTCCTCCTCCTCCCCTCCAGCCGCTGGGAGCCGCGGGTC
GGACGAGCCGCCGCCTCCTTCTCTGCGTCCATGTATGAGGGGAAGAAGACGAAGAACATGTTCCTGACCCGGGCTCTGGAGAAGATATTG
GCCGACAAGGAAGTGAAGAAGGCGCATCACTCCCAGCTGCGCAAAGCTTGCGAGGTGGCGTTAGAGGAAATAAAAGCGGAAACTGAAAAA
CAGAGTCCTCCTCATGGAGAAGCAAAAGCTGGATCAAGCACCCTTCCACCAGTGAAATCAAAGACAAATTTTATTGAAGCAGACAAGTAC
TTCTTGCCTTTTGAGTTGGCATGCCAGTCCAAATGTCCTCGCATAGTTAGTACATCTCTAGATTGCTTACAGAAACTTATTGCTTATGGG
CACTTGACTGGCAATGCTCCAGATAGTACAACACCAGGCAAAAAATTAATTGATAGAATTATTGAAACAATATGTGGCTGCTTTCAGGGC
CCTCAGACAGATGAAGGAGTTCAGCTGCAGATAATAAAGGCTTTACTTACTGCAGTAACATCACAACACATAGAAATTCATGAAGGGACT
GTACTGCAAGCTGTGAGAACATGTTACAATATCTACTTAGCAAGCAAAAATCTCATCAATCAGACAACAGCCAAAGCTACTCTCACTCAG
ATGCTAAATGTTATCTTTGCACGCATGGAAAACCAAGCATTACAGGAAGCAAAACAAATGGAAAAAGAAAGGCATCGGCAGCATCATCAT
CTGTTACAGTCTCCAGTAAGCCATCACGAGCCTGAATCACCTCAACTTAGATATTTGCCACCTCAGACTGTTGATCATATATCCCAAGAA
CACGAAGGGGACCTTGACCTCCATACAAATGATGTAGATAAAAGTCTTCAGGATGACACAGAGCCTGAAAATGGATCTGATATTTCCAGT
GCAGAAAATGAACAGACTGAAGCTGATCAGGCAACTGCAGCTGAAACATTATCTAAAAATGAAGTGTTATATGACGGAGAAAACCATGAT
TGTGAGGAAAAGCCACAAGACATTGTACAGAACATTGTAGAAGAAATGGTGAACATTGTTGTTGGAGATATGGGAGAAGGGACTACTATA
AATGCAAGTGCAGATGGCAACATTGGAACTATAGAGGATGGTAGTGACAGTGAAAATATTCAAGCAAATGGAATTCCAGGAACACCAATT
TCTGTTGCATATACACCATCCTTACCTGATGATAGATTGTCAGTCTCTTCCAATGATACTCAGGAATCTGGAAATTCTTCAGGACCTTCA
CCTGGTGCTAAGTTTTCCCACATTTTACAAAAGGATGCCTTTCTAGTATTCAGGTCATTGTGTAAACTGTCAATGAAACCACTGTCAGAT
GGACCACCAGATCCAAAGTCTCATGAACTACGATCCAAGATTCTTTCATTGCAGTTACTTCTATCCATTCTGCAGAATGCAGGACCTATT
TTCAGGACAAATGAGATGTTTATTAATGCTATTAAGCAGTATCTTTGTGTTGCACTCTCAAAAAATGGAGTCTCATCTGTTCCAGAGGTT
TTTGAGCTTTCTCTTTCTATATTTCTTACTTTGTTGTCAAATTTCAAGACACATCTGAAGATGCAAATTGAGGTGTTCTTTAAAGAAATT
TTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGAGGATTTGTGCAGATGCTCAG
AGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAAATGATCTATCAAAAATTGCT
CAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAGAATGCTTAGTGTCGATTTTG
AAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAAAACCCTCAGAGCAAGAGATG
AGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCATCAGGAATAGGCAGCTACAGT
ACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAACAAGGGATAGATTTATTTAAT
AAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTGCCCAATTCTTACATCAAGAG
GAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGTATGCATATGTGGACCAACAT
GACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAGCTCAGAAAATCGATCGATTA
ATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAGCTTATGTTTTGGCTTATTCA
ATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTAAGATGAATAGAGGTATCAAT
GACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAATGAAAGAAACAAAAGAACTA
ACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAGAAATGGAGCAGATGGCCAAG
ACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGCATGTGAGGCCCATGTTTAAG
GAAGACCTCTCTCTTTGCAAAAATCTTAGTGTTTTATATTTATATGATAATTGTATTAGTCAAATCACTAACCTGAATTATGCCACAAAT
CTGACCCACTTGTACCTACAAAACAATTGTATTTCATGTATAGAGAACCTCAGGTCATTAAAGAAACTGGAAAAACTGTATCTGGGAGGC
AATTACATTGCTGTCATAGAAGGTTTAGAAGGATTAGGAGAACTAAGAGAGCTTCATGTTGAGAATCAGAGGCTTCCCCTTGGGGAAAAG
CTTCTGTTTGATCCAAGAACTCTTCATTCTCTGGCAAAATCCCTCTGTATATTGAATATCAGCAATAATAATATTGATGACATTACAGAC
TTAGAACTACTAGAGAATCTTAATCAGCTCATAGCCGTTGACAACCAACTTCTGCATGTGAAGGATTTGGAGTTTTTACTGAACAAGTTG
ATGAAGCTGTGGAAAATTGATCTAAATGGAAATCCTGTTTGTCTCAAACCAAAATACAGGGACAGACTGATATTGGTGTCCAAATCACTG
GAATTTCTTGATGGAAAAGAAATTAAAAATATAGAAAGACAATTCCTAATGAATTGGAAAGCATCCAAAGATGCCAAGAAAATCAGCAAA
AAAAGGAGCAGTAAAAATGAGGATGCAAGCAATTCACTCATAAGTAACTTCAAAACAATGCATCATATAGTTCCTGTTTATTACCCACAG
GTGGGTAAGCCAAAATTAGCCTTTTTCTCTGAAATACAGAGATACCCTGTAAATGCAAATGCATCTCCAGAAAGTTCCTGAGAAGATTAC
ACTAAAATTATTTAAGAGATGGGGAATCTCTCTTTGAAGCAATCTGAAAGCTTGCTGACAAAAAATGATGTGCATGAACCTCACCTCTTC

>5859_5859_2_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000262215_PPP1R42_chr8_67926827_ENST00000522909_length(amino acids)=1216AA_BP=0
MYEGKKTKNMFLTRALEKILADKEVKKAHHSQLRKACEVALEEIKAETEKQSPPHGEAKAGSSTLPPVKSKTNFIEADKYFLPFELACQS
KCPRIVSTSLDCLQKLIAYGHLTGNAPDSTTPGKKLIDRIIETICGCFQGPQTDEGVQLQIIKALLTAVTSQHIEIHEGTVLQAVRTCYN
IYLASKNLINQTTAKATLTQMLNVIFARMENQALQEAKQMEKERHRQHHHLLQSPVSHHEPESPQLRYLPPQTVDHISQEHEGDLDLHTN
DVDKSLQDDTEPENGSDISSAENEQTEADQATAAETLSKNEVLYDGENHDCEEKPQDIVQNIVEEMVNIVVGDMGEGTTINASADGNIGT
IEDGSDSENIQANGIPGTPISVAYTPSLPDDRLSVSSNDTQESGNSSGPSPGAKFSHILQKDAFLVFRSLCKLSMKPLSDGPPDPKSHEL
RSKILSLQLLLSILQNAGPIFRTNEMFINAIKQYLCVALSKNGVSSVPEVFELSLSIFLTLLSNFKTHLKMQIEVFFKEIFLYILETSTS
SFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMVEWSKDQ
YVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYL
QEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKFAARYLE
CNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPTKSSKQN
VASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNC
ISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELLENLNQL
IAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLEFLDGKEIKNIERQFLMNWKASKDAKKISKKRSSKNEDAS

--------------------------------------------------------------
>5859_5859_3_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000520381_PPP1R42_chr8_67926827_ENST00000324682_length(transcript)=2090nt_BP=1280nt
AGGTGTTCTTTAAAGAAATTTTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGA
GGATTTGTGCAGATGCTCAGAGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAA
ATGATCTATCAAAAATTGCTCAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAG
AATGCTTAGTGTCGATTTTGAAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAA
AACCCTCAGAGCAAGAGATGAGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCAT
CAGGAATAGGCAGCTACAGTACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAAC
AAGGGATAGATTTATTTAATAAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTG
CCCAATTCTTACATCAAGAGGAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGT
ATGCATATGTGGACCAACATGACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAG
CTCAGAAAATCGATCGATTAATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAG
CTTATGTTTTGGCTTATTCAATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTA
AGATGAATAGAGGTATCAATGACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAA
TGAAAGAAACAAAAGAACTAACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAG
AAATGGAGCAGATGGCCAAGACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGC
ATGTGAGGCCCATGTTTAAGGAAGACCTCTCTCTTTGCAAAAATCTTAGTGTTTTATATTTATATGATAATTGTATTAGTCAAATCACTA
ACCTGAATTATGCCACAAATCTGACCCACTTGTACCTACAAAACAATTGTATTTCATGTATAGAGAACCTCAGGTCATTAAAGAAACTGG
AAAAACTGTATCTGGGAGGCAATTACATTGCTGTCATAGAAGGTTTAGAAGGATTAGGAGAACTAAGAGAGCTTCATGTTGAGAATCAGA
GGCTTCCCCTTGGGGAAAAGCTTCTGTTTGATCCAAGAACTCTTCATTCTCTGGCAAAATCCCTCTGTATATTGAATATCAGCAATAATA
ATATTGATGACATTACAGACTTAGAACTACTAGAGAATCTTAATCAGCTCATAGCCGTTGACAACCAACTTCTGCATGTGAAGGATTTGG
AGTTTTTACTGAACAAGTTGATGAAGCTGTGGAAAATTGATCTAAATGGAAATCCTGTTTGTCTCAAACCAAAATACAGGGACAGACTGA
TATTGGTGTCCAAATCACTGGGTACATATTTATATTAATATAATTTTTAAGAGAATGACACCTAGTTAACTTTTTGGTTATTTTACCAGC
AAGCTTTCAGAAATATAAATCTGACATCTGGATCTGTGAAAATTGTCAACTTTAAATTCAATATTTTGAATAAGAGCAAAAGTTAAAATT
GACAAATAAAGCATGAAAAACATCTGCTGTTCAGAAGTAATTAAAGCACCTGATACTTATTCCTTAAGGAGGATATTTTGCTATTACCAA

>5859_5859_3_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000520381_PPP1R42_chr8_67926827_ENST00000324682_length(amino acids)=601AA_BP=1
METSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMV
EWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPK
RGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKF
AARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPT
KSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHL
YLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL

--------------------------------------------------------------
>5859_5859_4_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000520381_PPP1R42_chr8_67926827_ENST00000522909_length(transcript)=2248nt_BP=1280nt
AGGTGTTCTTTAAAGAAATTTTCTTATACATTTTGGAAACTTCTACCAGCTCATTTGATCACAAATGGATGGTTATTCAGACACTGACGA
GGATTTGTGCAGATGCTCAGAGTGTAGTGGATATTTATGTAAACTATGACTGTGACTTAAATGCAGCCAATATATTTGAAAGACTAGTAA
ATGATCTATCAAAAATTGCTCAAGGAAGGGGCAGTCAAGAACTTGGTATGAGTAATGTTCAGGAATTGAGCCTGAGGAAAAAAGGTTTAG
AATGCTTAGTGTCGATTTTGAAGTGTATGGTTGAATGGAGTAAGGATCAGTATGTGAATCCCAACTCCCAGACAACTCTTGGTCAGGAAA
AACCCTCAGAGCAAGAGATGAGTGAAATCAAACACCCTGAGACAATAAACAGATACGGAAGTTTAAATTCCCTGGAGTCAACATCATCAT
CAGGAATAGGCAGCTACAGTACACAGATGTCTGGCACTGATAATCCAGAACAATTTGAGGTCCTAAAGCAACAAAAAGAAATAATAGAAC
AAGGGATAGATTTATTTAATAAGAAACCAAAGAGAGGAATACAGTACCTCCAAGAACAAGGGATGCTTGGCACCACACCTGAAGATATTG
CCCAATTCTTACATCAAGAGGAAAGATTAGACTCTACTCAAGTGGGTGAGTTCCTGGGAGATAATGATAAATTTAACAAAGAAGTCATGT
ATGCATATGTGGACCAACATGACTTTTCAGGAAAAGACTTCGTTTCAGCCCTTCGTATGTTTCTAGAAGGATTTCGTCTTCCAGGGGAAG
CTCAGAAAATCGATCGATTAATGGAAAAATTTGCTGCAAGATACCTAGAATGCAACCAAGGACAAACTCTCTTTGCTAGTGCGGATACAG
CTTATGTTTTGGCTTATTCAATTATCATGTTGACCACAGACCTTCACAGTCCACAGGTGAAAAATAAAATGACAAAGGAACAATACATTA
AGATGAATAGAGGTATCAATGACAGTAAAGACCTTCCTGAAGAGTATCTATCAGCCATCTATAATGAAATAGCTGGGAAAAAGATATCAA
TGAAAGAAACAAAAGAACTAACAATCCCTACAAAATCAAGTAAACAGAATGTAGCCAGTGAAAAACAAAGAAGACTTCTGTATAACTTAG
AAATGGAGCAGATGGCCAAGACAGCTAAAGCACTCATGGAGGCCGTGAGCCATGTTCAGGCACCCTTTACAAGTGCAACACATTTGGAGC
ATGTGAGGCCCATGTTTAAGGAAGACCTCTCTCTTTGCAAAAATCTTAGTGTTTTATATTTATATGATAATTGTATTAGTCAAATCACTA
ACCTGAATTATGCCACAAATCTGACCCACTTGTACCTACAAAACAATTGTATTTCATGTATAGAGAACCTCAGGTCATTAAAGAAACTGG
AAAAACTGTATCTGGGAGGCAATTACATTGCTGTCATAGAAGGTTTAGAAGGATTAGGAGAACTAAGAGAGCTTCATGTTGAGAATCAGA
GGCTTCCCCTTGGGGAAAAGCTTCTGTTTGATCCAAGAACTCTTCATTCTCTGGCAAAATCCCTCTGTATATTGAATATCAGCAATAATA
ATATTGATGACATTACAGACTTAGAACTACTAGAGAATCTTAATCAGCTCATAGCCGTTGACAACCAACTTCTGCATGTGAAGGATTTGG
AGTTTTTACTGAACAAGTTGATGAAGCTGTGGAAAATTGATCTAAATGGAAATCCTGTTTGTCTCAAACCAAAATACAGGGACAGACTGA
TATTGGTGTCCAAATCACTGGAATTTCTTGATGGAAAAGAAATTAAAAATATAGAAAGACAATTCCTAATGAATTGGAAAGCATCCAAAG
ATGCCAAGAAAATCAGCAAAAAAAGGAGCAGTAAAAATGAGGATGCAAGCAATTCACTCATAAGTAACTTCAAAACAATGCATCATATAG
TTCCTGTTTATTACCCACAGGTGGGTAAGCCAAAATTAGCCTTTTTCTCTGAAATACAGAGATACCCTGTAAATGCAAATGCATCTCCAG
AAAGTTCCTGAGAAGATTACACTAAAATTATTTAAGAGATGGGGAATCTCTCTTTGAAGCAATCTGAAAGCTTGCTGACAAAAAATGATG

>5859_5859_4_ARFGEF1-PPP1R42_ARFGEF1_chr8_68163534_ENST00000520381_PPP1R42_chr8_67926827_ENST00000522909_length(amino acids)=682AA_BP=1
METSTSSFDHKWMVIQTLTRICADAQSVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRGSQELGMSNVQELSLRKKGLECLVSILKCMV
EWSKDQYVNPNSQTTLGQEKPSEQEMSEIKHPETINRYGSLNSLESTSSSGIGSYSTQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPK
RGIQYLQEQGMLGTTPEDIAQFLHQEERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRLMEKF
AARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSAIYNEIAGKKISMKETKELTIPT
KSSKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHVQAPFTSATHLEHVRPMFKEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHL
YLQNNCISCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDITDLELL
ENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPVCLKPKYRDRLILVSKSLEFLDGKEIKNIERQFLMNWKASKDAKKISKKRSS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ARFGEF1-PPP1R42

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ARFGEF1-PPP1R42

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ARFGEF1-PPP1R42

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source