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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEO1-CNRIP1 (FusionGDB2 ID:58612)

Fusion Gene Summary for NEO1-CNRIP1

check button Fusion gene summary
Fusion gene informationFusion gene name: NEO1-CNRIP1
Fusion gene ID: 58612
HgeneTgene
Gene symbol

NEO1

CNRIP1

Gene ID

4756

25927

Gene nameneogenin 1cannabinoid receptor interacting protein 1
SynonymsIGDCC2|NGN|NTN1R2C2orf32|CRIP-1|CRIP1
Cytomap

15q24.1

2p14

Type of geneprotein-codingprotein-coding
Descriptionneogeninimmunoglobulin superfamily DCC subclass member 2neogenin homolog 1CB1 cannabinoid receptor-interacting protein 1cannabinoid receptor CB1-interacting protein 1
Modification date2020031320200313
UniProtAcc

Q92859

Q96F85

Ensembl transtripts involved in fusion geneENST00000261908, ENST00000339362, 
ENST00000558964, ENST00000560262, 
ENST00000560352, 		ENST00000481714, 
ENST00000263655, ENST00000409559, 
ENST00000409862, 
Fusion gene scores* DoF score14 X 7 X 7=6862 X 3 X 2=12
# samples 153
** MAII scorelog2(15/686*10)=-2.19324607567693
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NEO1 [Title/Abstract] AND CNRIP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEO1(73428368)-CNRIP1(68521158), # samples:4
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NEO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNRIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1326-01ANEO1chr15

73428368

-CNRIP1chr2

68521158

-
ChimerDB4OVTCGA-25-1326-01ANEO1chr15

73428368

+CNRIP1chr2

68521158

-
ChimerDB4OVTCGA-25-1326NEO1chr15

73428368

+CNRIP1chr2

68511616

-
ChimerDB4OVTCGA-25-1326NEO1chr15

73428368

+CNRIP1chr2

68521158

-


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Fusion Gene ORF analysis for NEO1-CNRIP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000261908ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-5UTRENST00000339362ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-5UTRENST00000558964ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-5UTRENST00000560262ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000261908ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000261908ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000261908ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000261908ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000261908ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000261908ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000339362ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000339362ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000339362ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000339362ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000339362ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000339362ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000558964ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000558964ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000558964ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000558964ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000558964ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000558964ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000560262ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000560262ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000560262ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000560262ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68521158

-
5CDS-intronENST00000560262ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68511616

-
5CDS-intronENST00000560262ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68511616

-
In-frameENST00000261908ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68511616

-
In-frameENST00000339362ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68511616

-
In-frameENST00000558964ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68511616

-
In-frameENST00000560262ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68511616

-
intron-3CDSENST00000560352ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68511616

-
intron-5UTRENST00000560352ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68521158

-
intron-intronENST00000560352ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68521158

-
intron-intronENST00000560352ENST00000263655NEO1chr15

73428368

+CNRIP1chr2

68511616

-
intron-intronENST00000560352ENST00000409559NEO1chr15

73428368

+CNRIP1chr2

68521158

-
intron-intronENST00000560352ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68521158

-
intron-intronENST00000560352ENST00000409862NEO1chr15

73428368

+CNRIP1chr2

68511616

-
intron-intronENST00000560352ENST00000481714NEO1chr15

73428368

+CNRIP1chr2

68511616

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000339362NEO1chr1573428368+ENST00000409559CNRIP1chr268511616-177614622671505412
ENST00000261908NEO1chr1573428368+ENST00000409559CNRIP1chr268511616-15211207121250412
ENST00000558964NEO1chr1573428368+ENST00000409559CNRIP1chr268511616-13951081301124364
ENST00000560262NEO1chr1573428368+ENST00000409559CNRIP1chr268511616-13951081301124364

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000339362ENST00000409559NEO1chr1573428368+CNRIP1chr268511616-0.0017720240.998228
ENST00000261908ENST00000409559NEO1chr1573428368+CNRIP1chr268511616-0.0014489920.99855095
ENST00000558964ENST00000409559NEO1chr1573428368+CNRIP1chr268511616-0.0009334570.99906653
ENST00000560262ENST00000409559NEO1chr1573428368+CNRIP1chr268511616-0.0009334570.99906653

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Fusion Genomic Features for NEO1-CNRIP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEO1-CNRIP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:73428368/chr2:68521158)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NEO1

Q92859

CNRIP1

Q96F85

FUNCTION: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}.FUNCTION: [Isoform 1]: Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. {ECO:0000269|PubMed:17895407}.; FUNCTION: [Isoform 2]: Does not suppress cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. {ECO:0000269|PubMed:17895407}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529152_2383381462.0DomainNote=Ig-like C2-type 2
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529243_3363381462.0DomainNote=Ig-like C2-type 3
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+52952_1413381462.0DomainNote=Ig-like C2-type 1
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630152_2383381462.0DomainNote=Ig-like C2-type 2
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630243_3363381462.0DomainNote=Ig-like C2-type 3
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+63052_1413381462.0DomainNote=Ig-like C2-type 1
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528152_2383381451.0DomainNote=Ig-like C2-type 2
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528243_3363381451.0DomainNote=Ig-like C2-type 3
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+52852_1413381451.0DomainNote=Ig-like C2-type 1
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528152_2383381409.0DomainNote=Ig-like C2-type 2
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528243_3363381409.0DomainNote=Ig-like C2-type 3
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+52852_1413381409.0DomainNote=Ig-like C2-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+5291118_11213381462.0Compositional biasNote=Poly-Val
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+6301118_11213381462.0Compositional biasNote=Poly-Val
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+5281118_11213381451.0Compositional biasNote=Poly-Val
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+5281118_11213381409.0Compositional biasNote=Poly-Val
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529341_4263381462.0DomainNote=Ig-like C2-type 4
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529441_5353381462.0DomainFibronectin type-III 1
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529541_6313381462.0DomainFibronectin type-III 2
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529636_7313381462.0DomainFibronectin type-III 3
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529741_8313381462.0DomainFibronectin type-III 4
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529856_9523381462.0DomainFibronectin type-III 5
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+529957_10543381462.0DomainFibronectin type-III 6
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630341_4263381462.0DomainNote=Ig-like C2-type 4
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630441_5353381462.0DomainFibronectin type-III 1
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630541_6313381462.0DomainFibronectin type-III 2
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630636_7313381462.0DomainFibronectin type-III 3
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630741_8313381462.0DomainFibronectin type-III 4
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630856_9523381462.0DomainFibronectin type-III 5
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+630957_10543381462.0DomainFibronectin type-III 6
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528341_4263381451.0DomainNote=Ig-like C2-type 4
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528441_5353381451.0DomainFibronectin type-III 1
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528541_6313381451.0DomainFibronectin type-III 2
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528636_7313381451.0DomainFibronectin type-III 3
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528741_8313381451.0DomainFibronectin type-III 4
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528856_9523381451.0DomainFibronectin type-III 5
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+528957_10543381451.0DomainFibronectin type-III 6
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528341_4263381409.0DomainNote=Ig-like C2-type 4
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528441_5353381409.0DomainFibronectin type-III 1
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528541_6313381409.0DomainFibronectin type-III 2
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528636_7313381409.0DomainFibronectin type-III 3
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528741_8313381409.0DomainFibronectin type-III 4
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528856_9523381409.0DomainFibronectin type-III 5
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+528957_10543381409.0DomainFibronectin type-III 6
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+5291127_14613381462.0Topological domainCytoplasmic
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+52934_11053381462.0Topological domainExtracellular
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+6301127_14613381462.0Topological domainCytoplasmic
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+63034_11053381462.0Topological domainExtracellular
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+5281127_14613381451.0Topological domainCytoplasmic
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+52834_11053381451.0Topological domainExtracellular
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+5281127_14613381409.0Topological domainCytoplasmic
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+52834_11053381409.0Topological domainExtracellular
HgeneNEO1chr15:73428368chr2:68511616ENST00000261908+5291106_11263381462.0TransmembraneHelical
HgeneNEO1chr15:73428368chr2:68511616ENST00000339362+6301106_11263381462.0TransmembraneHelical
HgeneNEO1chr15:73428368chr2:68511616ENST00000558964+5281106_11263381451.0TransmembraneHelical
HgeneNEO1chr15:73428368chr2:68511616ENST00000560262+5281106_11263381409.0TransmembraneHelical


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Fusion Gene Sequence for NEO1-CNRIP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58612_58612_1_NEO1-CNRIP1_NEO1_chr15_73428368_ENST00000261908_CNRIP1_chr2_68511616_ENST00000409559_length(transcript)=1521nt_BP=1207nt
GAGGGAGGCGCCCTGGAGTCTCCCCTCCAGCGAGAGGGGCTGCGCGGGCCGGGCCGGGCCGGGCTGGGCTGGAGCAGCGGCGGCCGCGGG
AGCCGAGCTTGCAGCGAGGGACCGGCTGAGGCGCGCGGGAGGGAAGGAGGCAAGGGCTCCGCGGCGCTGTCGCCGCCGCTGCCGCTCACT
CTCGGGGAAGAGATGGCGGCGGAGCGGGGAGCCCGGCGACTCCTCAGCACCCCCTCCTTCTGGCTCTACTGCCTGCTGCTGCTCGGGCGC
CGGGCGCCGGGCGCCGCGGCCGCCAGGAGCGGCTCCGCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATTTTATTTTCTG
GTGGAGCCGGTGGATACACTCTCAGTTAGAGGCTCTTCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGG
AAAAAAGATGGAACTTTTTTAAACTTAGTATCAGATGATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCAT
TCCAAACACAATAAACCTGATGAAGGTTATTATCAGTGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTC
ATAGTAGCAGGTCTTCCAAGATTTACCAGCCAACCAGAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAAT
GCAGATTTGGTCCCATTTGTGAGGTGGGAACAGAACAGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTG
GTTATCAGCAATGCAACTGAAGGAGATGGCGGGCTTTATCGCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAA
TTGAAGGTTCTTCCAGATCCTGAGGTGATATCAGACTTGGTATTTTTGAAACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTA
GTGTTGCCATGTGTTGCTTCAGGACTTCCTACTCCAACCATTAAATGGATGAAAAATGAGGAGGCACTTGACACAGAAAGCTCTGAAAGA
TTGGTATTGCTGGCAGGTGGTAGCCTGGAGATCAGTGATGTTACTGAGGATGATGCTGGGACTTATTTTTGTATAGCTGATAATGGAAAT
GAGACAATTGAAGCTCAAGCAGAGCTTACAGTGCAAGGAGTGCCTGGAACAACGACCCCAAGAGATCTCTCTTACATATGAATGTGAAGA
ATAAGCACATTCTTCAATGTGTGCCATCATGAGGAACAAATGTTCTTTTTTTTTTTTCCAAATTATTTGCTTTGCATTCTAGGGGAGGGC
TTCTCACAGGCCATCAGAATTATCGGGGATGCTTGTTAAAATGTAGATTCCTAAACTCTACCTTTTTAGACCTCTTAAATTGAGCAAACT

>58612_58612_1_NEO1-CNRIP1_NEO1_chr15_73428368_ENST00000261908_CNRIP1_chr2_68511616_ENST00000409559_length(amino acids)=412AA_BP=
MESPLQREGLRGPGRAGLGWSSGGRGSRACSEGPAEARGREGGKGSAALSPPLPLTLGEEMAAERGARRLLSTPSFWLYCLLLLGRRAPG
AAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISN
ATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL

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>58612_58612_2_NEO1-CNRIP1_NEO1_chr15_73428368_ENST00000339362_CNRIP1_chr2_68511616_ENST00000409559_length(transcript)=1776nt_BP=1462nt
GGTCAGCGGCTGCGCGGCCGGCCCCCTCCCACGGGAGCCGCGCCAGGGCCCAGCAAGAGTCGGGCGGGATCGCTATTGTTTTTGGCGAGC
ACATAAATCCCCGGGCCGACCCACTGCGCACCCAGGTTTCCTCCCGGAGGCCTTTCGGTTTCCTCTGAGGCCCTATATAGAGGCTCCAGG
CCCGGACTGTGCAGAGGTGCGCGCCCACGCCGGCCTCCCGGACCAGCCTGAGCTCGGAGCGCCTCTCGCCCTCAGGAGGGAGGCGCCCTG
GAGTCTCCCCTCCAGCGAGAGGGGCTGCGCGGGCCGGGCCGGGCCGGGCTGGGCTGGAGCAGCGGCGGCCGCGGGAGCCGAGCTTGCAGC
GAGGGACCGGCTGAGGCGCGCGGGAGGGAAGGAGGCAAGGGCTCCGCGGCGCTGTCGCCGCCGCTGCCGCTCACTCTCGGGGAAGAGATG
GCGGCGGAGCGGGGAGCCCGGCGACTCCTCAGCACCCCCTCCTTCTGGCTCTACTGCCTGCTGCTGCTCGGGCGCCGGGCGCCGGGCGCC
GCGGCCGCCAGGAGCGGCTCCGCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATTTTATTTTCTGGTGGAGCCGGTGGAT
ACACTCTCAGTTAGAGGCTCTTCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGGAAAAAAGATGGAACT
TTTTTAAACTTAGTATCAGATGATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCATTCCAAACACAATAAA
CCTGATGAAGGTTATTATCAGTGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTCATAGTAGCAGGTCTT
CCAAGATTTACCAGCCAACCAGAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAATGCAGATTTGGTCCCA
TTTGTGAGGTGGGAACAGAACAGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTGGTTATCAGCAATGCA
ACTGAAGGAGATGGCGGGCTTTATCGCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAATTGAAGGTTCTTCCA
GATCCTGAGGTGATATCAGACTTGGTATTTTTGAAACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTAGTGTTGCCATGTGTT
GCTTCAGGACTTCCTACTCCAACCATTAAATGGATGAAAAATGAGGAGGCACTTGACACAGAAAGCTCTGAAAGATTGGTATTGCTGGCA
GGTGGTAGCCTGGAGATCAGTGATGTTACTGAGGATGATGCTGGGACTTATTTTTGTATAGCTGATAATGGAAATGAGACAATTGAAGCT
CAAGCAGAGCTTACAGTGCAAGGAGTGCCTGGAACAACGACCCCAAGAGATCTCTCTTACATATGAATGTGAAGAATAAGCACATTCTTC
AATGTGTGCCATCATGAGGAACAAATGTTCTTTTTTTTTTTTCCAAATTATTTGCTTTGCATTCTAGGGGAGGGCTTCTCACAGGCCATC
AGAATTATCGGGGATGCTTGTTAAAATGTAGATTCCTAAACTCTACCTTTTTAGACCTCTTAAATTGAGCAAACTCTCTGAGAGTAAATC

>58612_58612_2_NEO1-CNRIP1_NEO1_chr15_73428368_ENST00000339362_CNRIP1_chr2_68511616_ENST00000409559_length(amino acids)=412AA_BP=
MESPLQREGLRGPGRAGLGWSSGGRGSRACSEGPAEARGREGGKGSAALSPPLPLTLGEEMAAERGARRLLSTPSFWLYCLLLLGRRAPG
AAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHN
KPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISN
ATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLL

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>58612_58612_3_NEO1-CNRIP1_NEO1_chr15_73428368_ENST00000558964_CNRIP1_chr2_68511616_ENST00000409559_length(transcript)=1395nt_BP=1081nt
GGGAGGGAAGGAGGCAAGGGCTCCGCGGCGCTGTCGCCGCCGCTGCCGCTCACTCTCGGGGAAGAGATGGCGGCGGAGCGGGGAGCCCGG
CGACTCCTCAGCACCCCCTCCTTCTGGCTCTACTGCCTGCTGCTGCTCGGGCGCCGGGCGCCGGGCGCCGCGGCCGCCAGGAGCGGCTCC
GCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATTTTATTTTCTGGTGGAGCCGGTGGATACACTCTCAGTTAGAGGCTCT
TCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGGAAAAAAGATGGAACTTTTTTAAACTTAGTATCAGAT
GATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCATTCCAAACACAATAAACCTGATGAAGGTTATTATCAG
TGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTCATAGTAGCAGGTCTTCCAAGATTTACCAGCCAACCA
GAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAATGCAGATTTGGTCCCATTTGTGAGGTGGGAACAGAAC
AGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTGGTTATCAGCAATGCAACTGAAGGAGATGGCGGGCTT
TATCGCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAATTGAAGGTTCTTCCAGATCCTGAGGTGATATCAGAC
TTGGTATTTTTGAAACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTAGTGTTGCCATGTGTTGCTTCAGGACTTCCTACTCCA
ACCATTAAATGGATGAAAAATGAGGAGGCACTTGACACAGAAAGCTCTGAAAGATTGGTATTGCTGGCAGGTGGTAGCCTGGAGATCAGT
GATGTTACTGAGGATGATGCTGGGACTTATTTTTGTATAGCTGATAATGGAAATGAGACAATTGAAGCTCAAGCAGAGCTTACAGTGCAA
GGAGTGCCTGGAACAACGACCCCAAGAGATCTCTCTTACATATGAATGTGAAGAATAAGCACATTCTTCAATGTGTGCCATCATGAGGAA
CAAATGTTCTTTTTTTTTTTTCCAAATTATTTGCTTTGCATTCTAGGGGAGGGCTTCTCACAGGCCATCAGAATTATCGGGGATGCTTGT
TAAAATGTAGATTCCTAAACTCTACCTTTTTAGACCTCTTAAATTGAGCAAACTCTCTGAGAGTAAATCCAAAGCATCTGCATTTTATTA

>58612_58612_3_NEO1-CNRIP1_NEO1_chr15_73428368_ENST00000558964_CNRIP1_chr2_68511616_ENST00000409559_length(amino acids)=364AA_BP=
MSPPLPLTLGEEMAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYS
EPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNN
AILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPL
VRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQGVPGTTTPRD

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>58612_58612_4_NEO1-CNRIP1_NEO1_chr15_73428368_ENST00000560262_CNRIP1_chr2_68511616_ENST00000409559_length(transcript)=1395nt_BP=1081nt
GGGAGGGAAGGAGGCAAGGGCTCCGCGGCGCTGTCGCCGCCGCTGCCGCTCACTCTCGGGGAAGAGATGGCGGCGGAGCGGGGAGCCCGG
CGACTCCTCAGCACCCCCTCCTTCTGGCTCTACTGCCTGCTGCTGCTCGGGCGCCGGGCGCCGGGCGCCGCGGCCGCCAGGAGCGGCTCC
GCGCCGCAGTCCCCAGGAGCCAGCATTCGAACGTTCACTCCATTTTATTTTCTGGTGGAGCCGGTGGATACACTCTCAGTTAGAGGCTCT
TCTGTTATATTAAACTGTTCAGCATATTCTGAGCCTTCTCCAAAAATTGAATGGAAAAAAGATGGAACTTTTTTAAACTTAGTATCAGAT
GATCGACGCCAGCTTCTCCCGGATGGATCTTTATTTATCAGCAATGTGGTGCATTCCAAACACAATAAACCTGATGAAGGTTATTATCAG
TGTGTGGCCACTGTTGAGAGTCTTGGAACTATTATCAGTAGAACAGCGAAGCTCATAGTAGCAGGTCTTCCAAGATTTACCAGCCAACCA
GAACCTTCCTCAGTTTATGCTGGGAACAATGCAATTCTGAATTGTGAAGTTAATGCAGATTTGGTCCCATTTGTGAGGTGGGAACAGAAC
AGACAACCCCTTCTTCTGGATGATAGAGTTATCAAACTTCCAAGTGGAATGCTGGTTATCAGCAATGCAACTGAAGGAGATGGCGGGCTT
TATCGCTGCGTAGTGGAAAGTGGTGGGCCACCAAAGTATAGTGATGAAGTTGAATTGAAGGTTCTTCCAGATCCTGAGGTGATATCAGAC
TTGGTATTTTTGAAACAGCCTTCTCCCTTAGTCAGAGTCATTGGTCAGGATGTAGTGTTGCCATGTGTTGCTTCAGGACTTCCTACTCCA
ACCATTAAATGGATGAAAAATGAGGAGGCACTTGACACAGAAAGCTCTGAAAGATTGGTATTGCTGGCAGGTGGTAGCCTGGAGATCAGT
GATGTTACTGAGGATGATGCTGGGACTTATTTTTGTATAGCTGATAATGGAAATGAGACAATTGAAGCTCAAGCAGAGCTTACAGTGCAA
GGAGTGCCTGGAACAACGACCCCAAGAGATCTCTCTTACATATGAATGTGAAGAATAAGCACATTCTTCAATGTGTGCCATCATGAGGAA
CAAATGTTCTTTTTTTTTTTTCCAAATTATTTGCTTTGCATTCTAGGGGAGGGCTTCTCACAGGCCATCAGAATTATCGGGGATGCTTGT
TAAAATGTAGATTCCTAAACTCTACCTTTTTAGACCTCTTAAATTGAGCAAACTCTCTGAGAGTAAATCCAAAGCATCTGCATTTTATTA

>58612_58612_4_NEO1-CNRIP1_NEO1_chr15_73428368_ENST00000560262_CNRIP1_chr2_68511616_ENST00000409559_length(amino acids)=364AA_BP=
MSPPLPLTLGEEMAAERGARRLLSTPSFWLYCLLLLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVDTLSVRGSSVILNCSAYS
EPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNVVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNN
AILNCEVNADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVELKVLPDPEVISDLVFLKQPSPL
VRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQGVPGTTTPRD

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Fusion Gene PPI Analysis for NEO1-CNRIP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEO1-CNRIP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEO1-CNRIP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource