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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NET1-RIMKLB (FusionGDB2 ID:58631)

Fusion Gene Summary for NET1-RIMKLB

check button Fusion gene summary
Fusion gene informationFusion gene name: NET1-RIMKLB
Fusion gene ID: 58631
HgeneTgene
Gene symbol

NET1

RIMKLB

Gene ID

55119

57494

Gene namepre-mRNA processing factor 38Bribosomal modification protein rimK like family member B
SynonymsNET1FAM80B|NAAGS|NAAGS-I
Cytomap

1p13.3

12p13.31

Type of geneprotein-codingprotein-coding
Descriptionpre-mRNA-splicing factor 38BPRP38 pre-mRNA processing factor 38 domain containing Bsarcoma antigen NY-SAR-27beta-citrylglutamate synthase BN-acetyl-aspartyl-glutamate synthetase BN-acetyl-aspartylglutamate synthetase BN-acetylaspartyl-glutamate synthetase BNAAG synthetase Bbeta-citryl-glutamate synthase Bfamily with sequence similarity 80, member Briboso
Modification date2020031320200313
UniProtAcc

Q7Z628

.
Ensembl transtripts involved in fusion geneENST00000355029, ENST00000542715, 
ENST00000380359, ENST00000484741, 
ENST00000299673, ENST00000538135, 
ENST00000357529, ENST00000535829, 
Fusion gene scores* DoF score6 X 4 X 5=1207 X 7 X 5=245
# samples 89
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NET1 [Title/Abstract] AND RIMKLB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNET1(5471192)-RIMKLB(8925917), # samples:3
Anticipated loss of major functional domain due to fusion event.NET1-RIMKLB seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
NET1-RIMKLB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across NET1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RIMKLB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-YU-A94I-01ANET1chr10

5471192

-RIMKLBchr12

8925917

+
ChimerDB4TGCTTCGA-YU-A94I-01ANET1chr10

5471192

+RIMKLBchr12

8925917

+
ChimerDB4TGCTTCGA-YU-A94INET1chr10

5471192

+RIMKLBchr12

8925916

+
ChimerDB4TGCTTCGA-YU-A94INET1chr10

5471192

+RIMKLBchr12

8925917

+


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Fusion Gene ORF analysis for NET1-RIMKLB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000355029ENST00000299673NET1chr10

5471192

+RIMKLBchr12

8925917

+
5CDS-3UTRENST00000355029ENST00000299673NET1chr10

5471192

+RIMKLBchr12

8925916

+
5CDS-3UTRENST00000355029ENST00000538135NET1chr10

5471192

+RIMKLBchr12

8925917

+
5CDS-3UTRENST00000355029ENST00000538135NET1chr10

5471192

+RIMKLBchr12

8925916

+
5UTR-3CDSENST00000542715ENST00000357529NET1chr10

5471192

+RIMKLBchr12

8925917

+
5UTR-3CDSENST00000542715ENST00000357529NET1chr10

5471192

+RIMKLBchr12

8925916

+
5UTR-3CDSENST00000542715ENST00000535829NET1chr10

5471192

+RIMKLBchr12

8925917

+
5UTR-3CDSENST00000542715ENST00000535829NET1chr10

5471192

+RIMKLBchr12

8925916

+
5UTR-3UTRENST00000542715ENST00000299673NET1chr10

5471192

+RIMKLBchr12

8925917

+
5UTR-3UTRENST00000542715ENST00000299673NET1chr10

5471192

+RIMKLBchr12

8925916

+
5UTR-3UTRENST00000542715ENST00000538135NET1chr10

5471192

+RIMKLBchr12

8925917

+
5UTR-3UTRENST00000542715ENST00000538135NET1chr10

5471192

+RIMKLBchr12

8925916

+
Frame-shiftENST00000355029ENST00000357529NET1chr10

5471192

+RIMKLBchr12

8925917

+
Frame-shiftENST00000355029ENST00000357529NET1chr10

5471192

+RIMKLBchr12

8925916

+
In-frameENST00000355029ENST00000535829NET1chr10

5471192

+RIMKLBchr12

8925917

+
In-frameENST00000355029ENST00000535829NET1chr10

5471192

+RIMKLBchr12

8925916

+
intron-3CDSENST00000380359ENST00000357529NET1chr10

5471192

+RIMKLBchr12

8925917

+
intron-3CDSENST00000380359ENST00000357529NET1chr10

5471192

+RIMKLBchr12

8925916

+
intron-3CDSENST00000380359ENST00000535829NET1chr10

5471192

+RIMKLBchr12

8925917

+
intron-3CDSENST00000380359ENST00000535829NET1chr10

5471192

+RIMKLBchr12

8925916

+
intron-3CDSENST00000484741ENST00000357529NET1chr10

5471192

+RIMKLBchr12

8925917

+
intron-3CDSENST00000484741ENST00000357529NET1chr10

5471192

+RIMKLBchr12

8925916

+
intron-3CDSENST00000484741ENST00000535829NET1chr10

5471192

+RIMKLBchr12

8925917

+
intron-3CDSENST00000484741ENST00000535829NET1chr10

5471192

+RIMKLBchr12

8925916

+
intron-3UTRENST00000380359ENST00000299673NET1chr10

5471192

+RIMKLBchr12

8925917

+
intron-3UTRENST00000380359ENST00000299673NET1chr10

5471192

+RIMKLBchr12

8925916

+
intron-3UTRENST00000380359ENST00000538135NET1chr10

5471192

+RIMKLBchr12

8925917

+
intron-3UTRENST00000380359ENST00000538135NET1chr10

5471192

+RIMKLBchr12

8925916

+
intron-3UTRENST00000484741ENST00000299673NET1chr10

5471192

+RIMKLBchr12

8925917

+
intron-3UTRENST00000484741ENST00000299673NET1chr10

5471192

+RIMKLBchr12

8925916

+
intron-3UTRENST00000484741ENST00000538135NET1chr10

5471192

+RIMKLBchr12

8925917

+
intron-3UTRENST00000484741ENST00000538135NET1chr10

5471192

+RIMKLBchr12

8925916

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355029NET1chr105471192+ENST00000535829RIMKLBchr128925917+1482397408860150
ENST00000355029NET1chr105471192+ENST00000535829RIMKLBchr128925916+1482397408860150

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355029ENST00000535829NET1chr105471192+RIMKLBchr128925917+0.0035105290.99648947
ENST00000355029ENST00000535829NET1chr105471192+RIMKLBchr128925916+0.0035105290.99648947

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Fusion Genomic Features for NET1-RIMKLB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NET1chr105471192+RIMKLBchr128925916+1.15E-060.9999988
NET1chr105471192+RIMKLBchr128925916+1.15E-060.9999988
NET1chr105471192+RIMKLBchr128925916+1.15E-060.9999988
NET1chr105471192+RIMKLBchr128925916+1.15E-060.9999988

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NET1-RIMKLB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:5471192/chr12:8925917)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NET1

Q7Z628

.
FUNCTION: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNET1chr10:5471192chr12:8925916ENST00000355029+31212_1985597.0MotifNuclear localization signal
HgeneNET1chr10:5471192chr12:8925916ENST00000355029+31266_7285597.0MotifNuclear localization signal
HgeneNET1chr10:5471192chr12:8925917ENST00000355029+31212_1985597.0MotifNuclear localization signal
HgeneNET1chr10:5471192chr12:8925917ENST00000355029+31266_7285597.0MotifNuclear localization signal
HgeneNET1chr10:5471192chr12:8925916ENST00000355029+3121_7485597.0RegionNecessary for nuclear localization
HgeneNET1chr10:5471192chr12:8925917ENST00000355029+3121_7485597.0RegionNecessary for nuclear localization

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNET1chr10:5471192chr12:8925916ENST00000355029+312174_35685597.0DomainDH
HgeneNET1chr10:5471192chr12:8925916ENST00000355029+312386_50185597.0DomainPH
HgeneNET1chr10:5471192chr12:8925916ENST00000380359+110174_3560543.0DomainDH
HgeneNET1chr10:5471192chr12:8925916ENST00000380359+110386_5010543.0DomainPH
HgeneNET1chr10:5471192chr12:8925917ENST00000355029+312174_35685597.0DomainDH
HgeneNET1chr10:5471192chr12:8925917ENST00000355029+312386_50185597.0DomainPH
HgeneNET1chr10:5471192chr12:8925917ENST00000380359+110174_3560543.0DomainDH
HgeneNET1chr10:5471192chr12:8925917ENST00000380359+110386_5010543.0DomainPH
HgeneNET1chr10:5471192chr12:8925916ENST00000380359+11012_190543.0MotifNuclear localization signal
HgeneNET1chr10:5471192chr12:8925916ENST00000380359+11066_720543.0MotifNuclear localization signal
HgeneNET1chr10:5471192chr12:8925917ENST00000380359+11012_190543.0MotifNuclear localization signal
HgeneNET1chr10:5471192chr12:8925917ENST00000380359+11066_720543.0MotifNuclear localization signal
HgeneNET1chr10:5471192chr12:8925916ENST00000380359+1101_740543.0RegionNecessary for nuclear localization
HgeneNET1chr10:5471192chr12:8925917ENST00000380359+1101_740543.0RegionNecessary for nuclear localization
TgeneRIMKLBchr10:5471192chr12:8925916ENST0000035752957119_304232387.0DomainATP-grasp
TgeneRIMKLBchr10:5471192chr12:8925916ENST0000053582946119_304232387.0DomainATP-grasp
TgeneRIMKLBchr10:5471192chr12:8925916ENST0000053813546119_304232387.0DomainATP-grasp
TgeneRIMKLBchr10:5471192chr12:8925917ENST0000035752957119_304232387.0DomainATP-grasp
TgeneRIMKLBchr10:5471192chr12:8925917ENST0000053582946119_304232387.0DomainATP-grasp
TgeneRIMKLBchr10:5471192chr12:8925917ENST0000053813546119_304232387.0DomainATP-grasp
TgeneRIMKLBchr10:5471192chr12:8925916ENST0000035752957193_203232387.0Nucleotide bindingATP
TgeneRIMKLBchr10:5471192chr12:8925916ENST0000053582946193_203232387.0Nucleotide bindingATP
TgeneRIMKLBchr10:5471192chr12:8925916ENST0000053813546193_203232387.0Nucleotide bindingATP
TgeneRIMKLBchr10:5471192chr12:8925917ENST0000035752957193_203232387.0Nucleotide bindingATP
TgeneRIMKLBchr10:5471192chr12:8925917ENST0000053582946193_203232387.0Nucleotide bindingATP
TgeneRIMKLBchr10:5471192chr12:8925917ENST0000053813546193_203232387.0Nucleotide bindingATP


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Fusion Gene Sequence for NET1-RIMKLB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58631_58631_1_NET1-RIMKLB_NET1_chr10_5471192_ENST00000355029_RIMKLB_chr12_8925916_ENST00000535829_length(transcript)=1482nt_BP=397nt
ATTTTCAAATCCCCGGATGACGGCGGTGGCGGCTGCAGTCCGCTGACAGGCGCTTTCTGCCTGGCAGAGGCTGGCGGGCATCGTGCCCGT
CCCTGCCGGTCTCCCGGGCACCCGGCCACCGCCCCACCCCCTCCTCCGTGCCATGGAGCCCGAGCTGGCGGCTCAGAAGCAGCCTCGACC
GCGGAGGCGAAGCCGCCGGGCCTCTGGGCTCAGCACGGAGGGAGCGACGGGGCCTTCGGCCGACACCTCCGGGTCGGAGCTGGACGGGAG
ATGTTCCCTTCGGAGAGGCAGCTCCTTCACATTCTTAACACCTGGCCCCAACTGGGACTTCACTTTGAAAAGAAAACGCAGAGAGAAAGA
TGATGATGTTGTAAGCCTTAGCAGCCTTGATCTGAAGGTGGTGTGGGGATGATGTGCTCATTGAGTGAACAAGGGAAGCAGCTAGCTATC
CAGGTGTCTAATATCCTGGGGATGGATGTGTGTGGCATTGATCTGCTGATGAAAGATGACGGCTCCTTCTGCGTCTGTGAGGCCAATGCA
AATGTAGGTTTCATCGCCTTTGATAAGGCTTGTAATCTAGATGTAGCTGGTATCATAGCAGACTATGCCGCCTCCCTTCTACCCTCTGGC
CGGCTCACCCGGCGTATGTCCCTGCTCTCCGTGGTGTCCACTGCCAGTGAGACTAGTGAGCCGGAGCTGGGTCCCCCAGCCAGCACTGCT
GTTGACAACATGAGTGCAAGTTCCAGCTCTGTTGACAGCGACCCTGAAAGCACGGAGCGAGAGCTGCTCACCAAGCTCCCAGGGGGCCTG
TTCAACATGAACCAGCTGCTAGCCAATGAAATCAAACTACTGGTGGACTGACTCCACTGGTAATTAACCAACAAAACCCTTGTAAAACTT
TCTTTCTTCTTTTCTATTTTTAAAACCAACTTGCAATGCTGTTCATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGGATTAGTTG
GAGAGAGTGGGAGATAGATGAGACCTCTGCTAGTAAGATGTTACTTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAGGTGGGGTA
TAGAAAAATGTCAGGCTCTCATAGTTACCCTTTTAAATTGCTAAAAAATGTGTATGCTCATAGGCCATGAGGAACAAATACTTTTTTTTT
TTCATGGTCCCTTGCTTTTGTTTTTGTACAAAAAAAAATGGTTTTGCTACAAATATCCAAGTAGCATAACTTCACATTGTGTTGGAAGAT
TTGTCATCAGTGAGGAAAACATCTGCATAAATTACAGGAATTTTTGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTATTAACTAGC
AGCTTTAGTTTGTAGTTTATGAAATCTTGAGGGGCTCTTTTACTGGGATTTCTTATTTTTTTGTTTTTTCCCGCTTAATTTGGTGGGAGG

>58631_58631_1_NET1-RIMKLB_NET1_chr10_5471192_ENST00000355029_RIMKLB_chr12_8925916_ENST00000535829_length(amino acids)=150AA_BP=
MMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGIIADYAASLLPSGRLTRRMSLLSVVSTAS

--------------------------------------------------------------
>58631_58631_2_NET1-RIMKLB_NET1_chr10_5471192_ENST00000355029_RIMKLB_chr12_8925917_ENST00000535829_length(transcript)=1482nt_BP=397nt
ATTTTCAAATCCCCGGATGACGGCGGTGGCGGCTGCAGTCCGCTGACAGGCGCTTTCTGCCTGGCAGAGGCTGGCGGGCATCGTGCCCGT
CCCTGCCGGTCTCCCGGGCACCCGGCCACCGCCCCACCCCCTCCTCCGTGCCATGGAGCCCGAGCTGGCGGCTCAGAAGCAGCCTCGACC
GCGGAGGCGAAGCCGCCGGGCCTCTGGGCTCAGCACGGAGGGAGCGACGGGGCCTTCGGCCGACACCTCCGGGTCGGAGCTGGACGGGAG
ATGTTCCCTTCGGAGAGGCAGCTCCTTCACATTCTTAACACCTGGCCCCAACTGGGACTTCACTTTGAAAAGAAAACGCAGAGAGAAAGA
TGATGATGTTGTAAGCCTTAGCAGCCTTGATCTGAAGGTGGTGTGGGGATGATGTGCTCATTGAGTGAACAAGGGAAGCAGCTAGCTATC
CAGGTGTCTAATATCCTGGGGATGGATGTGTGTGGCATTGATCTGCTGATGAAAGATGACGGCTCCTTCTGCGTCTGTGAGGCCAATGCA
AATGTAGGTTTCATCGCCTTTGATAAGGCTTGTAATCTAGATGTAGCTGGTATCATAGCAGACTATGCCGCCTCCCTTCTACCCTCTGGC
CGGCTCACCCGGCGTATGTCCCTGCTCTCCGTGGTGTCCACTGCCAGTGAGACTAGTGAGCCGGAGCTGGGTCCCCCAGCCAGCACTGCT
GTTGACAACATGAGTGCAAGTTCCAGCTCTGTTGACAGCGACCCTGAAAGCACGGAGCGAGAGCTGCTCACCAAGCTCCCAGGGGGCCTG
TTCAACATGAACCAGCTGCTAGCCAATGAAATCAAACTACTGGTGGACTGACTCCACTGGTAATTAACCAACAAAACCCTTGTAAAACTT
TCTTTCTTCTTTTCTATTTTTAAAACCAACTTGCAATGCTGTTCATGGAGGATGCTCAGGAAGATGAGAGAAAATTAGTAGGATTAGTTG
GAGAGAGTGGGAGATAGATGAGACCTCTGCTAGTAAGATGTTACTTTCATTTACAAATCCTACAAATAGAGAGGCAGAATAGGTGGGGTA
TAGAAAAATGTCAGGCTCTCATAGTTACCCTTTTAAATTGCTAAAAAATGTGTATGCTCATAGGCCATGAGGAACAAATACTTTTTTTTT
TTCATGGTCCCTTGCTTTTGTTTTTGTACAAAAAAAAATGGTTTTGCTACAAATATCCAAGTAGCATAACTTCACATTGTGTTGGAAGAT
TTGTCATCAGTGAGGAAAACATCTGCATAAATTACAGGAATTTTTGTATTATACAGCTCTGAAAATTCTGCCATTTCCTTATTAACTAGC
AGCTTTAGTTTGTAGTTTATGAAATCTTGAGGGGCTCTTTTACTGGGATTTCTTATTTTTTTGTTTTTTCCCGCTTAATTTGGTGGGAGG

>58631_58631_2_NET1-RIMKLB_NET1_chr10_5471192_ENST00000355029_RIMKLB_chr12_8925917_ENST00000535829_length(amino acids)=150AA_BP=
MMCSLSEQGKQLAIQVSNILGMDVCGIDLLMKDDGSFCVCEANANVGFIAFDKACNLDVAGIIADYAASLLPSGRLTRRMSLLSVVSTAS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NET1-RIMKLB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NET1-RIMKLB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NET1-RIMKLB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource