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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NEU3-POLA2 (FusionGDB2 ID:58641)

Fusion Gene Summary for NEU3-POLA2

Fusion gene summary

Fusion gene information	Fusion gene name: NEU3-POLA2
	Fusion gene ID: 58641
		Hgene	Tgene
	Gene symbol	NEU3	POLA2
	Gene ID	10825	23649
	Gene name	neuraminidase 3	DNA polymerase alpha 2, accessory subunit
	Synonyms	SIAL3	-
	Cytomap	11q13.4	11q13.1
	Type of gene	protein-coding	protein-coding
	Description	sialidase-3N-acetyl-alpha-neuraminidase 3ganglioside sialidasemembrane sialidasesialidase 3 (membrane sialidase)	DNA polymerase alpha subunit BDNA polymerase alpha 70 kDa subunitpolymerase (DNA directed), alpha 2 (70kD subunit)polymerase (DNA directed), alpha 2, accessory subunitpolymerase (DNA) alpha 2, accessory subunitpolymerase (DNA-directed), alpha (70kD)
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000294064, ENST00000526068, ENST00000529024, ENST00000531509, ENST00000531619, ENST00000532963, ENST00000534628, ENST00000544263, ENST00000545272,	ENST00000541089, ENST00000534785, ENST00000265465,
Fusion gene scores	* DoF score	4 X 5 X 2=40	10 X 14 X 6=840
	# samples	6	16
	** MAII score	log2(6/40*10)=0.584962500721156 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(16/840*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NEU3 [Title/Abstract] AND POLA2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NEU3(74705765)-POLA2(65043363), # samples:2
Anticipated loss of major functional domain due to fusion event.	NEU3-POLA2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NEU3-POLA2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NEU3-POLA2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NEU3	GO:0005975	carbohydrate metabolic process	12730204
Hgene	NEU3	GO:0006689	ganglioside catabolic process	10861246
Hgene	NEU3	GO:0009313	oligosaccharide catabolic process	10861246

Fusion gene breakpoints across NEU3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across POLA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-LL-A6FQ-01A	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
ChimerDB4	BRCA	TCGA-LL-A6FQ-01A	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+

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Fusion Gene ORF analysis for NEU3-POLA2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000294064	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000294064	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000526068	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000529024	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000531509	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000531509	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000531619	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000531619	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000532963	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000534628	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000534628	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-5UTR	ENST00000544263	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000294064	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000294064	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000526068	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000529024	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000531509	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000531509	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000531619	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000531619	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000532963	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000534628	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000534628	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5CDS-intron	ENST00000544263	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
5UTR-3CDS	ENST00000544263	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5UTR-3CDS	ENST00000545272	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5UTR-5UTR	ENST00000544263	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5UTR-5UTR	ENST00000545272	ENST00000541089	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5UTR-intron	ENST00000544263	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
5UTR-intron	ENST00000545272	ENST00000534785	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
Frame-shift	ENST00000294064	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
Frame-shift	ENST00000526068	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
Frame-shift	ENST00000529024	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
Frame-shift	ENST00000531509	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
Frame-shift	ENST00000531619	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
Frame-shift	ENST00000532963	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
Frame-shift	ENST00000534628	ENST00000265465	NEU3	chr11	74700199	+	POLA2	chr11	65043363	+
Frame-shift	ENST00000534628	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
In-frame	ENST00000294064	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
In-frame	ENST00000531509	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
In-frame	ENST00000531619	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
In-frame	ENST00000544263	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-3CDS	ENST00000526068	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-3CDS	ENST00000529024	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-3CDS	ENST00000532963	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-3CDS	ENST00000545272	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-5UTR	ENST00000526068	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-5UTR	ENST00000529024	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-5UTR	ENST00000532963	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-5UTR	ENST00000545272	ENST00000541089	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-intron	ENST00000526068	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-intron	ENST00000529024	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-intron	ENST00000532963	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+
intron-intron	ENST00000545272	ENST00000534785	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000294064

NEU3

chr11

74705765

ENST00000265465

POLA2

chr11

65043363

4092

1233

615

2675

686

ENST00000531509

NEU3

chr11

74705765

ENST00000265465

POLA2

chr11

65043363

3655

796

415

2238

607

ENST00000544263

NEU3

chr11

74705765

ENST00000265465

POLA2

chr11

65043363

3236

377

1819

598

ENST00000531619

NEU3

chr11

74705765

ENST00000265465

POLA2

chr11

65043363

3283

424

118

1866

582

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000294064	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+	0.001689705	0.9983103
ENST00000531509	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+	0.001982777	0.9980172
ENST00000544263	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+	0.003219084	0.9967809
ENST00000531619	ENST00000265465	NEU3	chr11	74705765	+	POLA2	chr11	65043363	+	0.003043371	0.9969566

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Fusion Genomic Features for NEU3-POLA2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
NEU3	chr11	74700199	+	POLA2	chr11	65043362	+	1.64E-06	0.99999833
NEU3	chr11	74705765	+	POLA2	chr11	65043362	+	1.49E-08	1
NEU3	chr11	74700199	+	POLA2	chr11	65043362	+	1.64E-06	0.99999833
NEU3	chr11	74705765	+	POLA2	chr11	65043362	+	1.49E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NEU3-POLA2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:74705765/chr11:65043363)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NEU3

chr11:74705765

chr11:65043363

ENST00000544263

24_27

429.0

Motif

Note=FRIP motif

Tgene

POLA2

chr11:74705765

chr11:65043363

ENST00000265465

115_157

118

599.0

Compositional bias

Note=Pro/Ser/Thr-rich

Tgene

POLA2

chr11:74705765

chr11:65043363

ENST00000265465

486_489

118

599.0

Compositional bias

Note=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NEU3

chr11:74705765

chr11:65043363

ENST00000544263

129_140

429.0

Repeat

Note=BNR 1

Hgene

NEU3

chr11:74705765

chr11:65043363

ENST00000544263

203_214

429.0

Repeat

Note=BNR 2

Hgene

NEU3

chr11:74705765

chr11:65043363

ENST00000544263

254_265

429.0

Repeat

Note=BNR 3

Tgene

POLA2

chr11:74705765

chr11:65043363

ENST00000265465

101_107

118

599.0

Compositional bias

Note=Poly-Glu

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Fusion Gene Sequence for NEU3-POLA2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>58641_58641_1_NEU3-POLA2_NEU3_chr11_74705765_ENST00000294064_POLA2_chr11_65043363_ENST00000265465_length(transcript)=4092nt_BP=1233nt
TTTCCTTTTATTGGCGTTTGTAAAATTTCTTCTTTTTAAAATTGTTATATTTTAGAGACAGGGTCTCGCTCTGTCACCCAGGCTGGAGTG
CAGTGGTGCAATCACAGCTCACCACAGCCTCCAACTCCTGGGCTCAAGGCATCCTCCCACGTAGGCCTTCCAAAGCGCTGAGATTGTAGG
CATAAGCCACCAGGCCCAGCCTATTACCTTTACGTTGTACTTAGTCCCAGATAAAAAATGACCTTAGATCAGTCCTTTCCTCTTTGGCTG
GGGAGAGGGGGGCTTAAATTCCGGTACTGTGAAACAGAAGAATGGACTCAGTGCTATGTGACAAATCTATGTATGTAAATGTGTGTATAT
ACACACACATAAATTATATATATGAATATATTTTCATTTTCATATTTTGCAAGGAGAGTAGCCAATGCTCTGGACCTCTGGTCCTTTTTG
TAGGGTACCCTCTGAGGCCGGGAACCTTTGCTCAACTCTCAGGCTGTCCAGGGAAGCTTTAGGCGGTGATACCGAGCTACAGACCAATAT
AAGAGCTCGGGGCTGTGGCACTGAAGAGAGGAGGCGGCCGTTGGGAACTGAGGTGGGCCCAGGGCTTGAGCTGAGTTGGCGAGGGTGGAG
GTGGTGCCGGTCCCACGCCGTGGTGGGGACCGAGCTGCGGGCTGGAGGGAGGGGCAGCGCCGAGGGGGCGGGACGGGGAGGGCTCGCGGA
GTAGGCCAACGGTTGGCCCCAACCGCCACTGACTACAGCCTGCGCCCGCCTCTTTTCGTTGCCGTTACCTGTTTCCGGCAGTCGACACGC
TCTTCGCTTCTCGGGGCTTGTCTCCGTGTCCTCCGTCTCAGTTGTTTCTCCCTCTCTATCCTCCTCTGTCTCAGTCTCCCCAGCCTTGGG
GCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCG
ACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGAT
GACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGG
AGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACC
CCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCC
TCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGA
GCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGA
GAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCA
CAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAA
CATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATC
AACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTT
GAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATC
AACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCA
TTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGA
GATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCC
GAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGT
TCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGAC
ATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTC
GTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGG
AGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTCT
GCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCAG
CCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAAG
CTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTTT
CTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTATT
TATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCCC
GGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAG
TGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGATT
ACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCCA
GAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAAA
GGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCTC
CCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGAG
TCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGTT
CACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCAG
GCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTGT
CTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATGGAATCGAGCCCCA

>58641_58641_1_NEU3-POLA2_NEU3_chr11_74705765_ENST00000294064_POLA2_chr11_65043363_ENST00000265465_length(amino acids)=686AA_BP=206
MARVEVVPVPRRGGDRAAGWREGQRRGGGTGRARGVGQRLAPTATDYSLRPPLFVAVTCFRQSTRSSLLGACLRVLRLSCFSLSILLCLS
LPSLGAGASSGLRRMRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAE
KRSTRRDEDALHLVLRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSW
SGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVIL
EGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLD
LIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQ
VQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPS

--------------------------------------------------------------
>58641_58641_2_NEU3-POLA2_NEU3_chr11_74705765_ENST00000531509_POLA2_chr11_65043363_ENST00000265465_length(transcript)=3655nt_BP=796nt
CCCACGTAGGCCTTCCAAAGCGCTGAGATTGTAGGCATAAGCCACCAGGCCCAGCCTATTACCTTTACGTTGTACTTAGTCCCAGATAAA
AAATGACCTTAGATCAGTCCTTTCCTCTTTGGCTGGGGAGAGGGGGGCTTAAATTCCGGTACTGTGAAACAGAAGAATGGACTCAGTGCT
ATGTGACAAATCTATGTATGTAAATGTGTGTATATACACACACATAAATTATATATATGAATATATTTTCATTTTCATATTTTGCAAGGA
GAGTAGCCAATGCTCTGGACCTCTGGTCCTTTTTGTAGGGTACCCTCTGAGGCCGGGAACCTTTGCTCAACTCTCAGGCTGTCCAGGGAA
GCTTTAGGCGGTGATACCGAGCTACAGACCAATATAAGAGCTCGGGGCTGTGGCACTGAAGAGAGGAGGCGGCCGTTGGGAACTGAGTCT
CCCCAGCCTTGGGGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTC
CAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTT
CCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAA
GCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCG
AGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCC
AAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTC
TGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCT
CCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTT
GCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGA
GGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAAT
TATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGA
GGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCT
GATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCT
ACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGT
CCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGT
ACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGA
GGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCC
GCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGA
GCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCG
ACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCC
TCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGG
AGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTC
TCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAG
GCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCT
ATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCA
AGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTT
TTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCA
AAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATT
TGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTC
CTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGC
ATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGT
TCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAG
GCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGC
CCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGC
AAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATG

>58641_58641_2_NEU3-POLA2_NEU3_chr11_74705765_ENST00000531509_POLA2_chr11_65043363_ENST00000265465_length(amino acids)=607AA_BP=127
MKRGGGRWELSLPSLGAGASSGLRRMRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYI
PPTHTFLAFAEKRSTRRDEDALHLVLRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVV
TSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDS
NGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTT
SDSITYDPLLDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFS
YSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQL

--------------------------------------------------------------
>58641_58641_3_NEU3-POLA2_NEU3_chr11_74705765_ENST00000531619_POLA2_chr11_65043363_ENST00000265465_length(transcript)=3283nt_BP=424nt
CTCTTCGCTTCTCGGGGCTTGTCTCCGTGTCCTCCGTCTCAGTTGTTTCTCCCTCTCTATCCTCCTCTGTCTCAGTCTCCCCAGCCTTGG
GGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGCCCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCC
GACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAGTGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGA
TGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCCCCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAG
GAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGATTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTAC
CCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCCATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCC
CTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCTCCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGG
AGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAACTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCG
AGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGGAACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGC
ACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACGGGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGA
ACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGGAATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAAT
CAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTGTGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTT
TGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTGACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCAT
CAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGGATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCC
ATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCACAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAG
AGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACTCCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTC
CGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACATCCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAG
TTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCTTGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGA
CATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTGTCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTT
CGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTACCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAG
GAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTGTGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTC
TGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCCTGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCA
GCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTGTGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAA
GCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTGTGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTT
TCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCTGAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTAT
TTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTGGAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCC
CGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACTACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTA
GTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGAT
TACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTATCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCC
AGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGTCCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAA
AGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTAGAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCT
CCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCTCCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGA
GTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTGCCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGT
TCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCTGTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCA
GGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCTGTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTG
TCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAACTTTTGCCTCTCACCTTTCTGACGGTGAAATGGAATCGAGCCCC

>58641_58641_3_NEU3-POLA2_NEU3_chr11_74705765_ENST00000531619_POLA2_chr11_65043363_ENST00000265465_length(amino acids)=582AA_BP=102
MRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAFAEKRSTRRDEDALHLV
LRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVL
GCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPV
DLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLDLIAVINHDRPDVCI
LFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSING
VIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVC

--------------------------------------------------------------
>58641_58641_4_NEU3-POLA2_NEU3_chr11_74705765_ENST00000544263_POLA2_chr11_65043363_ENST00000265465_length(transcript)=3236nt_BP=377nt
AGAGAGGAGGCGGCCGTTGGGAACTGAGTCTCCCCAGCCTTGGGGCCGGTGCCTCTTCCGGGCTTCGGCGAATGAGACCTGCGGACCTGC
CCCCGCGCCCCATGGAAGAATCCCCGGCGTCCAGCTCTGCCCCGACAGAGACGGAGGAGCCGGGGTCCAGTGCAGAGGTCATGGAAGAAG
TGACAACATGCTCCTTCAACAGCCCTCTGTTCCGGCAGGAAGATGACAGAGGGATTACCTACCGGATCCCAGCCCTGCTCTACATACCCC
CCACCCACACCTTCCTGGCCTTTGCAGAGAAGCGTTCTACGAGGAGAGATGAGGATGCTCTCCACCTGGTGCTGAGGCGAGGGTTGAGGA
TTGGGCAGTTGGTACAGGGTTCTCAGAAGCGAGCTATCTCTACCCCAGAAACCCCCCTAACAAAAAGGAGTGTGTCAACTCGTAGCCCCC
ATCAGCTACTCTCACCGTCAAGTTTCTCTCCAAGTGCTACTCCCTCCCAGAAATACAACTCACGAAGTAACCGAGGAGAAGTGGTTACCT
CCTTCGGCTTAGCACAGGGAGTATCTTGGTCTGGGAGAGGAGGAGCTGGAAACATCAGCCTGAAGGTCTTGGGATGTCCAGAGGCACTAA
CTGGGAGCTACAAATCCATGTTTCAGAAGCTCCCAGACATTCGAGAAGTTCTGACCTGTAAGATAGAAGAACTTGGCAGCGAACTCAAGG
AACATTACAAGATTGAAGCTTTCACTCCTTTGCTAGCCCCAGCACAGGAGCCTGTCACTCTGCTGGGCCAGATTGGCTGTGATAGCAACG
GGAAGCTGAACAACAAGTCAGTGATTCTCGAGGGAGACCGGGAACATTCCTCGGGTGCTCAAATTCCAGTGGATTTATCTGAGCTTAAGG
AATATTCTCTGTTTCCTGGACAGGTTGTAATTATGGAAGGAATCAACACCACTGGTAGGAAACTTGTTGCCACCAAACTCTACGAGGGTG
TGCCACTTCCATTTTATCAGCCCACTGAAGAGGATGCAGACTTTGAGCAAAGCATGGTCCTGGTTGCCTGTGGACCATACACCACATCTG
ACAGCATCACGTATGACCCCCTGCTTGACCTGATTGCTGTCATCAACCATGACCGGCCAGATGTCTGCATCCTGTTTGGCCCTTTCCTGG
ATGCTAAGCATGAACAGGTGGAGAATTGTCTACTGACAAGTCCATTTGAAGACATTTTCAAGCAGTGTCTACGAACAATTATTGAAGGCA
CAAGAAGCTCCGGCTCCCACCTTGTCTTTGTCCCGTCATTGAGAGATGTGCACCATGAGCCTGTGTACCCCCAGCCGCCTTTCAGCTACT
CCGATCTGTCTCGAGAGGACAAAAAGCAAGTACAGTTTGTGTCCGAGCCCTGCAGCCTCTCCATAAACGGAGTGATCTTCGGCTTGACAT
CCACAGATCTGCTTTTCCACCTGGGGGCCGAGGAGATCAGTAGTTCTTCCGGAACTTCAGACAGATTCAGCCGAATACTCAAGCACATCT
TGACCCAGAGGAGCTACTACCCACTCTACCCGCCCCAAGAAGACATGGCCATTGACTATGAGTCGTTCTATGTTTACGCACAGCTGCCTG
TCACCCCAGATGTCCTCATCATCCCGTCAGAGCTGAGGTACTTCGTGAAGGATGTCCTCGGCTGTGTCTGTGTGAACCCTGGGCGCCTTA
CCAAAGGGCAGGTGGGAGGCACCTTCGCCCGACTCTACCTTAGGAGGCCGGCAGCGGACGGGGCAGAGAGGCAGAGCCCATGCATTGCTG
TGCAGGTCGTCAGGATCTGAGGCTTCTGTCCTCTGCTGTTCTCTGCTGTGTGGGCCCTTAAAGTCTTAGCCAAGAGCCAAGACATAGCCC
TGTGACAAGGTGAACAGTTGGGTGGGAAAGGAGAGAGGAGCCAGCCAGGGAGGGGCAGCTGCAGTGACCAGGCCCAGCAGGGAGGACTTG
TGCAGCCGGGCCTGCCTCTGAGTGGTGCCTCTCCTGGAAGGAAGCTCTTGCTTCTCAGTCCATGCTCCGTGTCCAGAAGTAAGCCAGCTG
TGGATCCCGCCCACTCAGAAAAGGCGAGAAGGCTTTGTGATTTTCTACATGAATCAAACACAGAAACAACTTTTGGAGAAATTAAATTCT
GAGTGTGACTTCTGAGTTTGACCTTTCTTCTATTTTCTTTTATTTATTTATTTTGTTTTTAGACGGAGTCTCGATCTGTCGCCCAGGCTG
GAGTGCAGTGGTGAGATCTCGGCTCACTGCAAGCTCTGCCGCCCGGGTTCATGCCATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGACT
ACAGGCACCCACCACCACGCCTGGCTAATTTTTTGTATTTTTAGTGGAGATGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCT
GACCTTGTGATCTGTCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGCGCCCGGCCCCTTTCTTCTATTTTCTTTA
TCCTGGTAGTAGACAAAGAATGTTGCCTATTTGACCTATGTCCAGAGAAGGCAGAGTGTCAGTCACACTGGGTTTCTATCCAGCCCCAGT
CCTGTCCAGTGGGTAACTCTCAGCCCCACTCCTCATCCCCCAAAGGCCCCAGTGACCTCTATGCTGCAGAGGTGCACTGGGTGGGCCCTA
GAGCTGGGCTGCAGAGCAAGCAACTGGCTGCATGCCTGGGCCTCCCTGCGCAGTTCCTCACATGCATGCTGTGGTCCCAGCCTGACCTCT
CCATCTGGAGGGGGCCGCCTCGCTGGGCTGTTCCAAAGCTGGAGTCCTGGTGGCAGCTGCTTTGCCAAGTCGCGCAGTAGCCAGGGCTTG
CCTGCAGCCCAGAACACTCAGACAGGGTCAGGCCTTCCAGGGTTCACAGCACGTCCCATGCCCCTATGTCCTGGCATCTGGGGAAAAGCT
GTCACTGGCCAGACGTGGAGTGGCTTCCTGCCCTAAGCTGGCAGGCTGTCCTGCCTCACATGCCAGAGCCAAGACCGGCAAACCCCAGCT
GTCAGGGCAGGGAAGTGGGCAAGGGGGCAGCAAGCTGCTGGTGTCTATGCCTTGACTCCGAGATAAATAGATGACCTAACAGTGGCCAAC

>58641_58641_4_NEU3-POLA2_NEU3_chr11_74705765_ENST00000544263_POLA2_chr11_65043363_ENST00000265465_length(amino acids)=598AA_BP=118
MSLPSLGAGASSGLRRMRPADLPPRPMEESPASSSAPTETEEPGSSAEVMEEVTTCSFNSPLFRQEDDRGITYRIPALLYIPPTHTFLAF
AEKRSTRRDEDALHLVLRRGLRIGQLVQGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGV
SWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSV
ILEGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPL
LDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDK
KQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLII

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NEU3-POLA2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NEU3-POLA2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NEU3-POLA2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source