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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NEXN-AK5 (FusionGDB2 ID:58660)

Fusion Gene Summary for NEXN-AK5

check button Fusion gene summary
Fusion gene informationFusion gene name: NEXN-AK5
Fusion gene ID: 58660
HgeneTgene
Gene symbol

NEXN

AK5

Gene ID

91624

26289

Gene namenexilin F-actin binding proteinadenylate kinase 5
SynonymsCMH20|NELINAK6
Cytomap

1p31.1

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionnexilinadenylate kinase isoenzyme 5AK 5ATP-AMP transphosphorylase 5adenylate kinase 6
Modification date2020031320200313
UniProtAcc.

Q9Y6K8

Ensembl transtripts involved in fusion geneENST00000480732, ENST00000330010, 
ENST00000334785, ENST00000457030, 
ENST00000294624, 		ENST00000344720, 
ENST00000354567, ENST00000317704, 
ENST00000478255, 
Fusion gene scores* DoF score4 X 4 X 4=647 X 6 X 6=252
# samples 57
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEXN [Title/Abstract] AND AK5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEXN(78399164)-AK5(77949002), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEXN

GO:0030334

regulation of cell migration

15823560

TgeneAK5

GO:0006165

nucleoside diphosphate phosphorylation

23416111

TgeneAK5

GO:0009142

nucleoside triphosphate biosynthetic process

23416111


check buttonFusion gene breakpoints across NEXN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0X1-01ANEXNchr1

78399164

-AK5chr1

77949002

+
ChimerDB4BRCATCGA-B6-A0X1-01ANEXNchr1

78399164

+AK5chr1

77949002

+


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Fusion Gene ORF analysis for NEXN-AK5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000480732ENST00000344720NEXNchr1

78399164

+AK5chr1

77949002

+
3UTR-3CDSENST00000480732ENST00000354567NEXNchr1

78399164

+AK5chr1

77949002

+
3UTR-intronENST00000480732ENST00000317704NEXNchr1

78399164

+AK5chr1

77949002

+
3UTR-intronENST00000480732ENST00000478255NEXNchr1

78399164

+AK5chr1

77949002

+
5CDS-intronENST00000330010ENST00000317704NEXNchr1

78399164

+AK5chr1

77949002

+
5CDS-intronENST00000330010ENST00000478255NEXNchr1

78399164

+AK5chr1

77949002

+
5CDS-intronENST00000334785ENST00000317704NEXNchr1

78399164

+AK5chr1

77949002

+
5CDS-intronENST00000334785ENST00000478255NEXNchr1

78399164

+AK5chr1

77949002

+
5CDS-intronENST00000457030ENST00000317704NEXNchr1

78399164

+AK5chr1

77949002

+
5CDS-intronENST00000457030ENST00000478255NEXNchr1

78399164

+AK5chr1

77949002

+
In-frameENST00000330010ENST00000344720NEXNchr1

78399164

+AK5chr1

77949002

+
In-frameENST00000330010ENST00000354567NEXNchr1

78399164

+AK5chr1

77949002

+
In-frameENST00000334785ENST00000344720NEXNchr1

78399164

+AK5chr1

77949002

+
In-frameENST00000334785ENST00000354567NEXNchr1

78399164

+AK5chr1

77949002

+
In-frameENST00000457030ENST00000344720NEXNchr1

78399164

+AK5chr1

77949002

+
In-frameENST00000457030ENST00000354567NEXNchr1

78399164

+AK5chr1

77949002

+
intron-3CDSENST00000294624ENST00000344720NEXNchr1

78399164

+AK5chr1

77949002

+
intron-3CDSENST00000294624ENST00000354567NEXNchr1

78399164

+AK5chr1

77949002

+
intron-intronENST00000294624ENST00000317704NEXNchr1

78399164

+AK5chr1

77949002

+
intron-intronENST00000294624ENST00000478255NEXNchr1

78399164

+AK5chr1

77949002

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000457030NEXNchr178399164+ENST00000354567AK5chr177949002+343215062972135612
ENST00000457030NEXNchr178399164+ENST00000344720AK5chr177949002+342815062972135612
ENST00000330010NEXNchr178399164+ENST00000354567AK5chr177949002+328213562971985562
ENST00000330010NEXNchr178399164+ENST00000344720AK5chr177949002+327813562971985562
ENST00000334785NEXNchr178399164+ENST00000354567AK5chr177949002+336114351842064626
ENST00000334785NEXNchr178399164+ENST00000344720AK5chr177949002+335714351842064626

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000457030ENST00000354567NEXNchr178399164+AK5chr177949002+0.0008799480.99912006
ENST00000457030ENST00000344720NEXNchr178399164+AK5chr177949002+0.0008834170.9991166
ENST00000330010ENST00000354567NEXNchr178399164+AK5chr177949002+0.0007630410.99923694
ENST00000330010ENST00000344720NEXNchr178399164+AK5chr177949002+0.0007676910.9992323
ENST00000334785ENST00000354567NEXNchr178399164+AK5chr177949002+0.0020692410.99793077
ENST00000334785ENST00000344720NEXNchr178399164+AK5chr177949002+0.0020729660.99792707

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Fusion Genomic Features for NEXN-AK5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NEXNchr178399164+AK5chr177949001+0.0002423920.9997576
NEXNchr178399164+AK5chr177949001+0.0002423920.9997576

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NEXN-AK5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:78399164/chr1:77949002)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AK5

Q9Y6K8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714386_391327537.0Nucleotide bindingATP 2
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714433_435327537.0Nucleotide bindingAMP 2
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714462_465327537.0Nucleotide bindingAMP 2
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714386_391353563.0Nucleotide bindingATP 2
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714433_435353563.0Nucleotide bindingAMP 2
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714462_465353563.0Nucleotide bindingAMP 2
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714377_559327537.0RegionAdenylate kinase 2
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714406_435327537.0RegionNMP 2
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714499_509327537.0RegionLID 2
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714377_559353563.0RegionAdenylate kinase 2
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714406_435353563.0RegionNMP 2
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714499_509353563.0RegionLID 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEXNchr1:78399164chr1:77949002ENST00000330010+91243_575353612.0Compositional biasGlu-rich
HgeneNEXNchr1:78399164chr1:77949002ENST00000334785+101343_575417676.0Compositional biasGlu-rich
HgeneNEXNchr1:78399164chr1:77949002ENST00000457030+91343_575403663.0Compositional biasGlu-rich
HgeneNEXNchr1:78399164chr1:77949002ENST00000330010+912582_670353612.0DomainIg-like
HgeneNEXNchr1:78399164chr1:77949002ENST00000334785+1013582_670417676.0DomainIg-like
HgeneNEXNchr1:78399164chr1:77949002ENST00000457030+913582_670403663.0DomainIg-like
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714142_147327537.0Nucleotide bindingATP 1
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714191_193327537.0Nucleotide bindingAMP 1
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714219_222327537.0Nucleotide bindingAMP 1
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714142_147353563.0Nucleotide bindingATP 1
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714191_193353563.0Nucleotide bindingAMP 1
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714219_222353563.0Nucleotide bindingAMP 1
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714133_316327537.0RegionAdenylate kinase 1
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714162_193327537.0RegionNMP 1
TgeneAK5chr1:78399164chr1:77949002ENST00000344720714256_266327537.0RegionLID 1
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714133_316353563.0RegionAdenylate kinase 1
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714162_193353563.0RegionNMP 1
TgeneAK5chr1:78399164chr1:77949002ENST00000354567714256_266353563.0RegionLID 1


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Fusion Gene Sequence for NEXN-AK5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58660_58660_1_NEXN-AK5_NEXN_chr1_78399164_ENST00000330010_AK5_chr1_77949002_ENST00000344720_length(transcript)=3278nt_BP=1356nt
AACAGCTGCAGCCGGCGCTGGGCCCGCCTGGAATGCGGGAACAGGCTGCACACCAGGACTTTTATGGAAACTTGCTGCTGGAGACGGCGG
CGGCGGCGGCGGCAGCGGCAGCCAGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCA
GGCGGGACGCGCACAGTCCCTCCACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATA
ATCAGCCCAAGACCACATAGAGCAAACATGAATGATATTTCCCAAAAGGCTGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGAT
GTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAG
GAACAAAGGAAGAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAA
AGGGCTGAACAGATTGAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCT
GTCAAATCATATAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAG
GAAGATAAAAGAATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGT
GAAGCAAAAAAAGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAA
GCTGAAGAGGAAGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAAC
CAAGACACAGCAAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAA
AAAAGGAAAGCAGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGAT
GACTCCCCAGAGATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAA
ATGGAAGAAGAAAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATG
GGAGAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATA
ATTGGTGGTCCTGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTG
CGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTG
GAGCTCCTGAAGGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAA
GAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGC
CGGAGCAGCCTGCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTAC
TACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATT
TTCTGAAGGCAAAAATGCATGTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTT
TTGTGTCACCGCCCCCACCAACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAA
TCATGCATGGTGTATTTGGGACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGC
AGGCCACACTCAGAGCTAGTCAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCA
TCTGGTTCTCCTCTCATTAAGCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGA
CAGCCCTGGGCATCTTCCTTTGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAA
TGCCTTGTACATGATATAGAGGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGT
AAAACCCAGGTTAGTCATCAGTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCT
GATAAATTGTGTAACCTAGTCTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGC
ATGAGATATTTGCTATTTCATTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGC
AAGTAAAAAAATACCCTAACAAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCT
TTCCAGGAGTTTGCAAACCTTGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTA
TCAATCAGTTGTAAAATCAGAGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGT
TTGCATGAATTTTTTTTTTTTTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTT

>58660_58660_1_NEXN-AK5_NEXN_chr1_78399164_ENST00000330010_AK5_chr1_77949002_ENST00000344720_length(amino acids)=562AA_BP=353
MNDISQKAEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDIN
NTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSP
GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEAR
RRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNV
FGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVA
SLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHK

--------------------------------------------------------------
>58660_58660_2_NEXN-AK5_NEXN_chr1_78399164_ENST00000330010_AK5_chr1_77949002_ENST00000354567_length(transcript)=3282nt_BP=1356nt
AACAGCTGCAGCCGGCGCTGGGCCCGCCTGGAATGCGGGAACAGGCTGCACACCAGGACTTTTATGGAAACTTGCTGCTGGAGACGGCGG
CGGCGGCGGCGGCAGCGGCAGCCAGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCA
GGCGGGACGCGCACAGTCCCTCCACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATA
ATCAGCCCAAGACCACATAGAGCAAACATGAATGATATTTCCCAAAAGGCTGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGAT
GTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAG
GAACAAAGGAAGAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAA
AGGGCTGAACAGATTGAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCT
GTCAAATCATATAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAG
GAAGATAAAAGAATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGT
GAAGCAAAAAAAGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAA
GCTGAAGAGGAAGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAAC
CAAGACACAGCAAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAA
AAAAGGAAAGCAGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGAT
GACTCCCCAGAGATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAA
ATGGAAGAAGAAAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATG
GGAGAGGGTGATGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATA
ATTGGTGGTCCTGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTG
CGTGAGGAACTGGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTG
GAGCTCCTGAAGGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAA
GAGTTCGGACGCAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGC
CGGAGCAGCCTGCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTAC
TACGAGACAAAAACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATT
TTCTGAAGGCAAAAATGCATGTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTT
TTGTGTCACCGCCCCCACCAACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAA
TCATGCATGGTGTATTTGGGACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGC
AGGCCACACTCAGAGCTAGTCAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCA
TCTGGTTCTCCTCTCATTAAGCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGA
CAGCCCTGGGCATCTTCCTTTGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAA
TGCCTTGTACATGATATAGAGGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGT
AAAACCCAGGTTAGTCATCAGTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCT
GATAAATTGTGTAACCTAGTCTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGC
ATGAGATATTTGCTATTTCATTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGC
AAGTAAAAAAATACCCTAACAAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCT
TTCCAGGAGTTTGCAAACCTTGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTA
TCAATCAGTTGTAAAATCAGAGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGT
TTGCATGAATTTTTTTTTTTTTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTT

>58660_58660_2_NEXN-AK5_NEXN_chr1_78399164_ENST00000330010_AK5_chr1_77949002_ENST00000354567_length(amino acids)=562AA_BP=353
MNDISQKAEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDIN
NTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSP
GKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEAR
RRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNV
FGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVA
SLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHK

--------------------------------------------------------------
>58660_58660_3_NEXN-AK5_NEXN_chr1_78399164_ENST00000334785_AK5_chr1_77949002_ENST00000344720_length(transcript)=3357nt_BP=1435nt
AGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCAGGCGGGACGCGCACAGTCCCTCC
ACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATAATCAGCCCAAGACCACATAGAGC
AAACATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACCTATGTACCAAAACTTGGCAAGGG
TGATGTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGA
ACAATATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAA
AGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAA
GAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACA
GATTGAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATA
TAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAG
AATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAA
AGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGA
AGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGC
AAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGC
AGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGA
GATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGA
AAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGA
TGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCC
TGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACT
GGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAA
GGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACG
CAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCT
GCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAA
AACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCA
AAAATGCATGTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCG
CCCCCACCAACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGT
GTATTTGGGACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTC
AGAGCTAGTCAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCC
TCTCATTAAGCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGC
ATCTTCCTTTGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACA
TGATATAGAGGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGT
TAGTCATCAGTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTG
TAACCTAGTCTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTT
GCTATTTCATTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAA
TACCCTAACAAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTT
TGCAAACCTTGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTG
TAAAATCAGAGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATT
TTTTTTTTTTTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGA

>58660_58660_3_NEXN-AK5_NEXN_chr1_78399164_ENST00000334785_AK5_chr1_77949002_ENST00000344720_length(amino acids)=626AA_BP=417
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKV
EKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYK
TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA
RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEM
YKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPG
SGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRR

--------------------------------------------------------------
>58660_58660_4_NEXN-AK5_NEXN_chr1_78399164_ENST00000334785_AK5_chr1_77949002_ENST00000354567_length(transcript)=3361nt_BP=1435nt
AGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCAGGCGGGACGCGCACAGTCCCTCC
ACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATAATCAGCCCAAGACCACATAGAGC
AAACATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACCTATGTACCAAAACTTGGCAAGGG
TGATGTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGAGACGAAAAACAAAGAAGAAAAGA
ACAATATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGATGATGAGGAAGATGTATCTTCTAA
AGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAACAAAGACAAGAGGAACAAAGGAA
GAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGTGAATTAGCAAAAAGGGCTGAACA
GATTGAGGACATAAACAATACGGGAACTGAATCAGCATCAGAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATA
TAAAACATCTGGAAAAATGAAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAG
AATAAGATATGAAGAACAACGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAA
AGAATCACTTTCTCCCGGAAAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGA
AGCAAGAAAACGTTTAGAAGAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGC
AAAAATTTTTAAAGGGTACCGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGC
AGAAGAAGAAGCCAGAAGGAGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGA
GATGTATAAGACAATCTCTCAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGA
AAAACGACGAACAGAGGAGGAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGA
TGACCAGTTAAATGTATTTGGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCC
TGGCTCTGGCAAAGGCACACAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACT
GGCATCAGAATCTGAAAGAAGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAA
GGAGGCCATGGTGGCCAGCCTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACG
CAGGATTGGAGACCCACAGTTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCT
GCCTGTGGACGACACCACCAAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAA
AACACAGCTACACAAGATAAATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCA
AAAATGCATGTTTGTTAGAATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCG
CCCCCACCAACCACCACCTCCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGT
GTATTTGGGACTATATCAACCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTC
AGAGCTAGTCAGTACATGAACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCC
TCTCATTAAGCATCCCTAACCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGC
ATCTTCCTTTGGTGTCTGGCTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACA
TGATATAGAGGCATCAAGCAAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGT
TAGTCATCAGTAACCTTCTCTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTG
TAACCTAGTCTCTTCTCTACATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTT
GCTATTTCATTCATTGGGCACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAA
TACCCTAACAAACCTGATGTGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTT
TGCAAACCTTGTCATACCCATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTG
TAAAATCAGAGCTGCTTATATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATT
TTTTTTTTTTTCTTCAATGGCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGA

>58660_58660_4_NEXN-AK5_NEXN_chr1_78399164_ENST00000334785_AK5_chr1_77949002_ENST00000354567_length(amino acids)=626AA_BP=417
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKV
EKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYK
TSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEA
RKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEM
YKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPG
SGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRR

--------------------------------------------------------------
>58660_58660_5_NEXN-AK5_NEXN_chr1_78399164_ENST00000457030_AK5_chr1_77949002_ENST00000344720_length(transcript)=3428nt_BP=1506nt
AACAGCTGCAGCCGGCGCTGGGCCCGCCTGGAATGCGGGAACAGGCTGCACACCAGGACTTTTATGGAAACTTGCTGCTGGAGACGGCGG
CGGCGGCGGCGGCAGCGGCAGCCAGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCA
GGCGGGACGCGCACAGTCCCTCCACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATA
ATCAGCCCAAGACCACATAGAGCAAACATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACC
TATGTACCAAAACTTGGCAAGGGTGATGTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGA
GACGAAAAACAAAGAAGAAAAGAACAATATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGAT
GATGAGGAAGATGTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAA
CAAAGACAAGAGGAACAAAGGAAGAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGT
GAATTAGCAAAAAGGGCTGAACAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAAACATCTGGAAAAATG
AAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAACAA
CGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAATCACTTTCTCCCGGA
AAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTAGAA
GAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAAATTTTTAAAGGGTAC
CGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGAAGG
AGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATGTATAAGACAATCTCT
CAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAGGAG
GAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGACCAGTTAAATGTATTT
GGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGCACA
CAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGA
AGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCCAGC
CTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAG
TTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACCACC
AAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATA
AATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCAAAAATGCATGTTTGTTAGA
ATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCGCCCCCACCAACCACCACCT
CCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGTGTATTTGGGACTATATCAA
CCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTCAGAGCTAGTCAGTACATGA
ACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCCTCTCATTAAGCATCCCTAA
CCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGCATCTTCCTTTGGTGTCTGG
CTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACATGATATAGAGGCATCAAGC
AAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGTTAGTCATCAGTAACCTTCT
CTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTGTAACCTAGTCTCTTCTCTA
CATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTTGCTATTTCATTCATTGGGC
ACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAATACCCTAACAAACCTGATG
TGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTTTGCAAACCTTGTCATACCC
ATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTGTAAAATCAGAGCTGCTTAT
ATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATTTTTTTTTTTTTCTTCAATG
GCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGATATGTACAAATAAAATAAA

>58660_58660_5_NEXN-AK5_NEXN_chr1_78399164_ENST00000457030_AK5_chr1_77949002_ENST00000344720_length(amino acids)=612AA_BP=403
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKV
EKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQEGDDSLLITVVPVKSYKTSGKMKKNFEDLEK
EREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEA
RRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKL
EINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKY
GFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSA

--------------------------------------------------------------
>58660_58660_6_NEXN-AK5_NEXN_chr1_78399164_ENST00000457030_AK5_chr1_77949002_ENST00000354567_length(transcript)=3432nt_BP=1506nt
AACAGCTGCAGCCGGCGCTGGGCCCGCCTGGAATGCGGGAACAGGCTGCACACCAGGACTTTTATGGAAACTTGCTGCTGGAGACGGCGG
CGGCGGCGGCGGCAGCGGCAGCCAGAGGACTCCCAGCGGCTGGAGCAGAAGTGTTAGCGGCCAGAGCTCCCAGACCCCTACCCACAGCCA
GGCGGGACGCGCACAGTCCCTCCACGCGGAAAGAAGTACCTTCGCCGGTCACCGGCTCCTGCAGGGTGCAAATATATACAGAGCTTCATA
ATCAGCCCAAGACCACATAGAGCAAACATGAATGATATTTCCCAAAAGGCTGAGATTCTGCTTTCTTCATCTAAACCTGTCCCAAAAACC
TATGTACCAAAACTTGGCAAGGGTGATGTAAAGGATAAGTTTGAAGCCATGCAGAGAGCCAGGGAAGAAAGAAATCAAAGGAGATCTAGA
GACGAAAAACAAAGAAGAAAAGAACAATATATTAGAGAGAGAGAATGGAACAGGAGAAAGCAGGAGATTAAAGAAATGCTTGCTTCTGAT
GATGAGGAAGATGTATCTTCTAAAGTAGAAAAGGCTTATGTTCCAAAATTAACAGGAACTGTGAAGGGTAGATTTGCTGAAATGGAGAAA
CAAAGACAAGAGGAACAAAGGAAGAGAACGGAGGAGGAACGAAAACGCAGAATTGAGCAGGATATGTTAGAAAAGAGGAAAATACAGCGT
GAATTAGCAAAAAGGGCTGAACAGGAAGGAGATGATTCACTACTTATAACTGTGGTACCTGTCAAATCATATAAAACATCTGGAAAAATG
AAAAAGAATTTTGAGGATCTAGAAAAAGAACGTGAAGAGAAAGAAAGGATCAAGTACGAGGAAGATAAAAGAATAAGATATGAAGAACAA
CGACCATCTCTCAAGGAAGCAAAGTGTCTTTCATTAGTTATGGATGATGAAATAGAAAGTGAAGCAAAAAAAGAATCACTTTCTCCCGGA
AAATTGAAACTAACTTTTGAAGAACTGGAGCGACAAAGACAAGAAAACCGAAAGAAGCAAGCTGAAGAGGAAGCAAGAAAACGTTTAGAA
GAAGAGAAGCGTGCTTTTGAAGAAGCAAGGCGGCAAATGGTAAATGAAGATGAGGAAAACCAAGACACAGCAAAAATTTTTAAAGGGTAC
CGCCCTGGTAAACTCAAACTCAGTTTTGAAGAAATGGAAAGGCAAAGAAGAGAAGATGAAAAAAGGAAAGCAGAAGAAGAAGCCAGAAGG
AGAATAGAGGAAGAAAAGAAGGCGTTTGCTGAAGCAAGGAGAAATATGGTAGTAGATGATGACTCCCCAGAGATGTATAAGACAATCTCT
CAAGAATTTCTTACACCGGGAAAACTGGAAATTAATTTTGAAGAATTATTAAAACAAAAAATGGAAGAAGAAAAACGACGAACAGAGGAG
GAACGGAAGCATAAGCTAGAAATGGAGAAACAAGAATTTGAACAACTGAGACAGGAAATGGGAGAGGGTGATGACCAGTTAAATGTATTT
GGAGAGGACACTATGGGAGGTTTCATGGAAGATTTGAGAAAGTGTAAAATTATTTTCATAATTGGTGGTCCTGGCTCTGGCAAAGGCACA
CAGTGTGAAAAGCTGGTGGAAAAATATGGATTTACACATCTCTCAACTGGCGAGCTCCTGCGTGAGGAACTGGCATCAGAATCTGAAAGA
AGCAAATTGATCAGAGACATTATGGAACGTGGAGACCTGGTGCCCTCAGGCATCGTTTTGGAGCTCCTGAAGGAGGCCATGGTGGCCAGC
CTCGGGGACACCAGGGGCTTCCTGATTGACGGCTATCCTCGGGAGGTGAAGCAAGGGGAAGAGTTCGGACGCAGGATTGGAGACCCACAG
TTGGTGATCTGTATGGACTGCTCGGCAGACACCATGACCAACCGCCTTCTCCAAAGGAGCCGGAGCAGCCTGCCTGTGGACGACACCACC
AAGACCATCGCCAAGCGCCTAGAAGCCTACTACCGAGCGTCCATCCCCGTGATCGCCTACTACGAGACAAAAACACAGCTACACAAGATA
AATGCAGAGGGAACACCAGAGGACGTTTTTCTTCAACTCTGCACAGCTATTGACTCTATTTTCTGAAGGCAAAAATGCATGTTTGTTAGA
ATGGAAACAGAAAAACATTAAAAAGTTCATTCCTTAACACAATGTTTCAAGTTAAACCTTTTGTGTCACCGCCCCCACCAACCACCACCT
CCTAAATCCTGACAGCACTGTTTGCTTCCCAGCTAGACCTGTGTGAGAGGTGTCTGGAAATCATGCATGGTGTATTTGGGACTATATCAA
CCTATTCTCCACACTTCAGACAACTGTCTGCACTCACGGCACACACACTTTGTATCATGCAGGCCACACTCAGAGCTAGTCAGTACATGA
ACAGTGGTGCGGTGCCAGTCTGTGTCCGTTGTGATCACAGGCCTTGCTAGACCCTGATCATCTGGTTCTCCTCTCATTAAGCATCCCTAA
CCCCCAGTCACACCTTCCTCTTACATACTGTTCCCCAATGGAGGCCCCTGGCATAGGGGACAGCCCTGGGCATCTTCCTTTGGTGTCTGG
CTGTTTTGTCAACTCTCATCCACTGGTGGCTCAGAGCCATAAGGTGGGTTGATTACACAATGCCTTGTACATGATATAGAGGCATCAAGC
AAGTAAAATTTGACAGAAATTTTAAAATATGAAGATGTATAGCTTTCCCAAGATGATGGTAAAACCCAGGTTAGTCATCAGTAACCTTCT
CTATTATTATTATTTTTTAGAAACTTGGAATACTGTCGTCATGGCTAAGAGAACAAATCTGATAAATTGTGTAACCTAGTCTCTTCTCTA
CATGGTGATGCATTTCAGCAATTATAAATTAATATAAATGACCAAAAGTAACTTAAAAGCATGAGATATTTGCTATTTCATTCATTGGGC
ACATATCAAATTATAATTTTGATTTTAAATGGTCACCCATGTATTTATTTGTTGCCAAGCAAGTAAAAAAATACCCTAACAAACCTGATG
TGGGTGGGAGGGGCATGTCAGTAAGTGGTGTGTTCAATGTGTTTGTTTCATATGGGCCCTTTCCAGGAGTTTGCAAACCTTGTCATACCC
ATATGCAAAACTGTGTTTCCTTGCATTAAACCAGTGAAGTTTGGGTTCTCTTTTGTGCTATCAATCAGTTGTAAAATCAGAGCTGCTTAT
ATATTCTACTGGAATAACTGCATCTTCCACTCAGTCACTACAAAAAAGCATAGTTTCAGTTTGCATGAATTTTTTTTTTTTTCTTCAATG
GCTGTGCAGATAAGGATCCATTTCTGGGATAGAATTGTATTTTTTAAGTCATTTTTTTTTCTTGAAATGGATATGTACAAATAAAATAAA

>58660_58660_6_NEXN-AK5_NEXN_chr1_78399164_ENST00000457030_AK5_chr1_77949002_ENST00000354567_length(amino acids)=612AA_BP=403
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKV
EKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQEGDDSLLITVVPVKSYKTSGKMKKNFEDLEK
EREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEA
RRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKL
EINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKY
GFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSA

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Fusion Gene PPI Analysis for NEXN-AK5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEXN-AK5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEXN-AK5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource