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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NF1-MAP2K4 (FusionGDB2 ID:58690)

Fusion Gene Summary for NF1-MAP2K4

check button Fusion gene summary
Fusion gene informationFusion gene name: NF1-MAP2K4
Fusion gene ID: 58690
HgeneTgene
Gene symbol

NF1

MAP2K4

Gene ID

4763

6416

Gene nameneurofibromin 1mitogen-activated protein kinase kinase 4
SynonymsNFNS|VRNF|WSSJNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1
Cytomap

17q11.2

17p12

Type of geneprotein-codingprotein-coding
Descriptionneurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1
Modification date2020032220200329
UniProtAcc.

P45985

Ensembl transtripts involved in fusion geneENST00000356175, ENST00000358273, 
ENST00000431387, ENST00000417592, 
ENST00000444181, ENST00000581113, 
ENST00000581941, ENST00000353533, 
ENST00000415385, 
Fusion gene scores* DoF score47 X 26 X 21=256628 X 10 X 6=480
# samples 6910
** MAII scorelog2(69/25662*10)=-5.21689344093196
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/480*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NF1 [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNF1(29509683)-MAP2K4(12028611), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNF1

GO:0043547

positive regulation of GTPase activity

2121371


check buttonFusion gene breakpoints across NF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MAP2K4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CHOLTCGA-W5-AA31-01ANF1chr17

29509683

-MAP2K4chr17

12028611

+
ChimerDB4CHOLTCGA-W5-AA31-01ANF1chr17

29509683

+MAP2K4chr17

12028611

+


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Fusion Gene ORF analysis for NF1-MAP2K4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000356175ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
5CDS-3UTRENST00000358273ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
5CDS-3UTRENST00000431387ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000356175ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000356175ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000358273ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000358273ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000431387ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
In-frameENST00000431387ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000417592ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000417592ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000444181ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000444181ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000581113ENST00000353533NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3CDSENST00000581113ENST00000415385NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3UTRENST00000417592ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3UTRENST00000444181ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+
intron-3UTRENST00000581113ENST00000581941NF1chr17

29509683

+MAP2K4chr17

12028611

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356175NF1chr1729509683+ENST00000353533MAP2K4chr1712028611+422112712541657467
ENST00000356175NF1chr1729509683+ENST00000415385MAP2K4chr1712028611+422812712541657467
ENST00000358273NF1chr1729509683+ENST00000353533MAP2K4chr1712028611+422112712541657467
ENST00000358273NF1chr1729509683+ENST00000415385MAP2K4chr1712028611+422812712541657467
ENST00000431387NF1chr1729509683+ENST00000353533MAP2K4chr1712028611+417112212041607467
ENST00000431387NF1chr1729509683+ENST00000415385MAP2K4chr1712028611+417812212041607467

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356175ENST00000353533NF1chr1729509683+MAP2K4chr1712028611+0.0002086090.99979144
ENST00000356175ENST00000415385NF1chr1729509683+MAP2K4chr1712028611+0.000206780.99979323
ENST00000358273ENST00000353533NF1chr1729509683+MAP2K4chr1712028611+0.0002086090.99979144
ENST00000358273ENST00000415385NF1chr1729509683+MAP2K4chr1712028611+0.000206780.99979323
ENST00000431387ENST00000353533NF1chr1729509683+MAP2K4chr1712028611+0.0002049630.999795
ENST00000431387ENST00000415385NF1chr1729509683+MAP2K4chr1712028611+0.0002035770.99979645

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Fusion Genomic Features for NF1-MAP2K4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NF1chr1729509683+MAP2K4chr1712028610+5.25E-050.99994755
NF1chr1729509683+MAP2K4chr1712028610+5.25E-050.99994755

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NF1-MAP2K4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:29509683/chr17:12028611)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAP2K4

P45985

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269|PubMed:7716521}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000353533611364_387271400.0RegionNote=DVD domain
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000415385712364_387282411.0RegionNote=DVD domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8571352_13552962819.0Compositional biasNote=Poly-Ser
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8581352_13552962840.0Compositional biasNote=Poly-Ser
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8151352_1355296594.0Compositional biasNote=Poly-Ser
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8571235_14512962819.0DomainRas-GAP
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8571580_17382962819.0DomainCRAL-TRIO
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8581235_14512962840.0DomainRas-GAP
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8581580_17382962840.0DomainCRAL-TRIO
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8151235_1451296594.0DomainRas-GAP
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8151580_1738296594.0DomainCRAL-TRIO
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8572555_25712962819.0MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8582555_25712962840.0MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8152555_2571296594.0MotifNote=Bipartite nuclear localization signal
HgeneNF1chr17:29509683chr17:12028611ENST00000356175+8571580_18372962819.0RegionNote=Lipid binding
HgeneNF1chr17:29509683chr17:12028611ENST00000358273+8581580_18372962840.0RegionNote=Lipid binding
HgeneNF1chr17:29509683chr17:12028611ENST00000431387+8151580_1837296594.0RegionNote=Lipid binding
TgeneMAP2K4chr17:29509683chr17:12028611ENST000003535336115_19271400.0Compositional biasNote=Gly/Ser-rich
TgeneMAP2K4chr17:29509683chr17:12028611ENST000004153857125_19282411.0Compositional biasNote=Gly/Ser-rich
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000353533611102_367271400.0DomainProtein kinase
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000415385712102_367282411.0DomainProtein kinase
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000353533611108_116271400.0Nucleotide bindingATP
TgeneMAP2K4chr17:29509683chr17:12028611ENST00000415385712108_116282411.0Nucleotide bindingATP
TgeneMAP2K4chr17:29509683chr17:12028611ENST0000035353361137_52271400.0RegionNote=D domain
TgeneMAP2K4chr17:29509683chr17:12028611ENST0000041538571237_52282411.0RegionNote=D domain


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Fusion Gene Sequence for NF1-MAP2K4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58690_58690_1_NF1-MAP2K4_NF1_chr17_29509683_ENST00000356175_MAP2K4_chr17_12028611_ENST00000353533_length(transcript)=4221nt_BP=1271nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAG
CCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAA
AACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTA
AAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACA
ACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGT
ATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGC
TGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGT
ATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAA
TGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGT
AAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTA
TACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTT
GTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAA
AACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAG
AAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTC
ACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTG
TTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
ACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTA
AGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAG
AAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGAT
ACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAA
AGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCG
CTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTT
TTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTT
TCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTC
TTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTT
CTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCA
CTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATT
GCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGC
AGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGT
TCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTC
TCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTA
ATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCA
AGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAG
CTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAA
AAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATA
TACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAA

>58690_58690_1_NF1-MAP2K4_NF1_chr17_29509683_ENST00000356175_MAP2K4_chr17_12028611_ENST00000353533_length(amino acids)=467AA_BP=339
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY
PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWS
LGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVC

--------------------------------------------------------------
>58690_58690_2_NF1-MAP2K4_NF1_chr17_29509683_ENST00000356175_MAP2K4_chr17_12028611_ENST00000415385_length(transcript)=4228nt_BP=1271nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAG
CCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAA
AACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTA
AAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACA
ACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGT
ATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGC
TGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGT
ATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAA
TGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGT
AAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTA
TACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTT
GTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAA
AACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAG
AAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTC
ACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTG
TTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
ACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTA
AGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAG
AAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGAT
ACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAA
AGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCG
CTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTT
TTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTT
TCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTC
TTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTT
CTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCA
CTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATT
GCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGC
AGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGT
TCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTC
TCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTA
ATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCA
AGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAG
CTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAA
AAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATA
TACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAA

>58690_58690_2_NF1-MAP2K4_NF1_chr17_29509683_ENST00000356175_MAP2K4_chr17_12028611_ENST00000415385_length(amino acids)=467AA_BP=339
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY
PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWS
LGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVC

--------------------------------------------------------------
>58690_58690_3_NF1-MAP2K4_NF1_chr17_29509683_ENST00000358273_MAP2K4_chr17_12028611_ENST00000353533_length(transcript)=4221nt_BP=1271nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAG
CCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAA
AACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTA
AAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACA
ACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGT
ATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGC
TGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGT
ATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAA
TGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGT
AAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTA
TACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTT
GTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAA
AACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAG
AAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTC
ACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTG
TTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
ACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTA
AGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAG
AAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGAT
ACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAA
AGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCG
CTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTT
TTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTT
TCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTC
TTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTT
CTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCA
CTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATT
GCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGC
AGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGT
TCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTC
TCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTA
ATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCA
AGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAG
CTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAA
AAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATA
TACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAA

>58690_58690_3_NF1-MAP2K4_NF1_chr17_29509683_ENST00000358273_MAP2K4_chr17_12028611_ENST00000353533_length(amino acids)=467AA_BP=339
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY
PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWS
LGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVC

--------------------------------------------------------------
>58690_58690_4_NF1-MAP2K4_NF1_chr17_29509683_ENST00000358273_MAP2K4_chr17_12028611_ENST00000415385_length(transcript)=4228nt_BP=1271nt
AATCTCTAGCTCGCTCGCGCTCCCTCTCCCCGGGCCGTGGAAAGGATCCCACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGAT
GGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCCCCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCC
TCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCCCCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTC
CACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCCCTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGC
CGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGGGTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAA
TAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAACAAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTT
TGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGAATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTC
AGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAGGACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGT
TGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAGCATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTAT
TTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACCAGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTG
ATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAATTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAG
CCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCATTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAA
AACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTATTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTA
AAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAAATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACA
ACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATATGATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGT
ATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTTGATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGC
TGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTCAACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGT
ATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCCGTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAA
TGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTACATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGT
AAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACCATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTA
TACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACACAGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTT
GTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGACTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAA
AACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCCTGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAG
AAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGCCTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTC
ACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACAGTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTG
TTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCATGTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGG
ACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGACTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTA
AGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACCTGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAG
AAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAACTTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGAT
ACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGTGCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAA
AGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCAGTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCG
CTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAAAACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTT
TTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGTGGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTT
TCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGTTCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTC
TTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCCTCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTT
CTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCCTGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCA
CTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGATGCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATT
GCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAGGGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGC
AGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATCTTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGT
TCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATCATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTC
TCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTATGCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTA
ATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTGTATTAATCATAGATTATTATAAACTATAAACTTAAGGGCA
AGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTTCACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAG
CTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAAAAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAA
AAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTATCCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATA
TACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGGTCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAA

>58690_58690_4_NF1-MAP2K4_NF1_chr17_29509683_ENST00000358273_MAP2K4_chr17_12028611_ENST00000415385_length(amino acids)=467AA_BP=339
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY
PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWS
LGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVC

--------------------------------------------------------------
>58690_58690_5_NF1-MAP2K4_NF1_chr17_29509683_ENST00000431387_MAP2K4_chr17_12028611_ENST00000353533_length(transcript)=4171nt_BP=1221nt
ACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGATGGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCC
CCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCCTCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCC
CCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTCCACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCC
CTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGCCGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGG
GTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAAC
AAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGA
ATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAG
GACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAG
CATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACC
AGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAA
TTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCA
TTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTA
TTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAA
ATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATAT
GATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTT
GATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTC
AACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCC
GTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTAC
ATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGTAAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACC
ATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTATACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACAC
AGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGA
CTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCC
TGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGC
CTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACA
GTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCAT
GTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGA
CTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTAAGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACC
TGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAAC
TTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGATACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGT
GCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCA
GTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAA
AACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGT
GGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGT
TCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCC
TCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTTCTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCC
TGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCACTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGAT
GCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATTGCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAG
GGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATC
TTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATC
ATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTAT
GCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTG
TATTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTT
CACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAA
AAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTAT
CCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATATACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGG
TCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAATTTGATTTTCTGAAATCAGACCCTGAGAGGGGAAAATCTTAAAGTAAATT

>58690_58690_5_NF1-MAP2K4_NF1_chr17_29509683_ENST00000431387_MAP2K4_chr17_12028611_ENST00000353533_length(amino acids)=467AA_BP=339
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY
PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWS
LGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVC

--------------------------------------------------------------
>58690_58690_6_NF1-MAP2K4_NF1_chr17_29509683_ENST00000431387_MAP2K4_chr17_12028611_ENST00000415385_length(transcript)=4178nt_BP=1221nt
ACTTCCGGTGGGGTGTCATGGCGGCGTCTCGGACTGTGATGGCTGTGGGGAGACGGCGCTAGTGGGGAGAGCGACCAAGAGGCCCCCTCC
CCTCCCCGGGTCCCCTTCCCCTATCCCCCTCCCCCCAGCCTCCTTGCCAACGCCCCCTTTCCCTCTCCCCCTCCCGCTCGGCGCTGACCC
CCCATCCCCACCCCCGTGGGAACACTGGGAGCCTGCACTCCACAGACCCTCTCCTTGCCTCTTCCCTCACCTCAGCCTCCGCTCCCCGCC
CTCTTCCCGGCCCAGGGCGCCGGCCCACCCTTCCCTCCGCCGCCCCCCGGCCGCGGGGAGGACATGGCCGCGCACAGGCCGGTGGAATGG
GTCCAGGCCGTGGTCAGCCGCTTCGACGAGCAGCTTCCAATAAAAACAGGACAGCAGAACACACATACCAAAGTCAGTACTGAGCACAAC
AAGGAATGTCTAATCAATATTTCCAAATACAAGTTTTCTTTGGTTATAAGCGGCCTCACTACTATTTTAAAGAATGTTAACAATATGAGA
ATATTTGGAGAAGCTGCTGAAAAAAATTTATATCTCTCTCAGTTGATTATATTGGATACACTGGAAAAATGTCTTGCTGGGCAACCAAAG
GACACAATGAGATTAGATGAAACGATGCTGGTCAAACAGTTGCTGCCAGAAATCTGCCATTTTCTTCACACCTGTCGTGAAGGAAACCAG
CATGCAGCTGAACTTCGGAATTCTGCCTCTGGGGTTTTATTTTCTCTCAGCTGCAACAACTTCAATGCAGTCTTTAGTCGCATTTCTACC
AGGTTACAGGAATTAACTGTTTGTTCAGAAGACAATGTTGATGTTCATGATATAGAATTGTTACAGTATATCAATGTGGATTGTGCAAAA
TTAAAACGACTCCTGAAGGAAACAGCATTTAAATTTAAAGCCCTAAAGAAGGTTGCGCAGTTAGCAGTTATAAATAGCCTGGAAAAGGCA
TTTTGGAACTGGGTAGAAAATTATCCAGATGAATTTACAAAACTGTACCAGATCCCACAGACTGATATGGCTGAATGTGCAGAAAAGCTA
TTTGACTTGGTGGATGGTTTTGCTGAAAGCACCAAACGTAAAGCAGCAGTTTGGCCACTACAAATCATTCTCCTTATCTTGTGTCCAGAA
ATAATCCAGGATATATCCAAAGACGTGGTTGATGAAAACAACATGAATAAGCCTGAAAGAATAGACCCAAGCGCATCACGACAAGGATAT
GATGTCCGCTCTGATGTCTGGAGTTTGGGGATCACATTGTATGAGTTGGCCACAGGCCGATTTCCTTATCCAAAGTGGAATAGTGTATTT
GATCAACTAACACAAGTCGTGAAAGGAGATCCTCCGCAGCTGAGTAATTCTGAGGAAAGGGAATTCTCCCCGAGTTTCATCAACTTTGTC
AACTTGTGCCTTACGAAGGATGAATCCAAAAGGCCAAAGTATAAAGAGCTTCTGAAACATCCCTTTATTTTGATGTATGAAGAACGTGCC
GTTGAGGTCGCATGCTATGTTTGTAAAATCCTGGATCAAATGCCAGCTACTCCCAGCTCTCCCATGTATGTCGATTGATATCGCTGCTAC
ATCAGACTCTAGAAAAAAGGGCTGAGAGGAAGCAAGACGTAAAGAATTTTCATCCCGTATCACAGTGTTTTTATTGCTCGCCCAGACACC
ATGTGCAATAAGATTGGTGTTCGTTTCCATCATGTCTGTATACTCCTGTCACCTAGAACGTGCATCCTTGTAATACCTGATTGATCACAC
AGTGTTAGTGCTGGTCAGAGAGACCTCATCCTGCTCTTTTGTGATGAACATATTCATGAAATGTGGAAGTCAGTACGATCAAGTTGTTGA
CTGTGATTAGATCACATCTTAAATTCATTTCTAGACTCAAAACCTGGAGATGCAGCTACTGGAATGGTGTTTTGTCAGACTTCCAAATCC
TGGAAGGACACAGTGATGAATGTACTATGTCTGAACATAGAAACTCGGGCTTGAGTGAGAAGAGCTTGCACAGCCAACGAGACACATTGC
CTTCTGGAGCTGGGAGACAAAGGAGGAATTTACTTTCTTCACCAAGTGCAATAGATTACTGATGTGATATTCTGTTGCTTTACAGTTACA
GTTGATGTTTGGGGATCGATGTGCTCAGCCAAATTTCCTGTTTGAAATATCATGTTAAATTAGAATGAATTTATCTTTACCAAAAACCAT
GTTGCGTTCAAAGAGGTGAACATTAAAATATAGAGACAGGACAGAATGTGTTCTTTTCTCCTTTACCAGTCCTATTTTTCAATGGGAAGA
CTCAGGAGTCTGCCACTTGTCAAAGAAGGTGCTGATCCTAAGAATTTTTCATTCTCAGAATTCGGTGTGCTGCCAACTTGATGTTCCACC
TGCCACAAACCACCAGGACTGAAAGAAGAAAACAGTACAGAAGGCAAAGTTTACAGATGTTTTTAATTCTAGTATTTTATCTGGAACAAC
TTGTAGCAGCTATATATTTCCCCTTGGTCCCAAGCCTGATACTTTAGCCATCATAACTCACTAACAGGGAGAAGTAGCTAGTAGCAATGT
GCCTTGATTGATTAGATAAAGATTTCTAGTAGGCAGCAAAAGACCAAATCTCAGTTGTTTGCTTCTTGCCATCACTGGTCCAGGTCTTCA
GTTTCCGAATCTCTTTCCCTTCCCCTGTGGTCTATTGTCGCTATGTGACTTGCGCTTAATCCAATATTTTGCCTTTTTTCTATATCAAAA
AACCTTTACAGTTAGCAGGGATGTTCCTTACCAAGGATTTTTAGCCCCAAATCTCTCATATTCGCTAGTGTTTAAAAGGCTAAGAATAGT
GGGGCCCAGCCGATGTGGTAGGTGATAAAGAGGCATCTTTTCTAGAGACACATTGGACCAGATGAGGATCCGAAACGGCAGCCTTTACGT
TCATCACCTGCTAGAACCTCTCGTAGTCCATCACCATTTCTTGGCATTGGAATTCTACTGGAAAAAAATACAAAAAGCAAAACAAAACCC
TCAGCACTGTTACAAGAGGCCATTTAAGTATCTTGTGCTTCTTCACTTACCCATTAGCCAGGTTCTCATTAGGTTTTGCTTGGGCCTCCC
TGGCACTGAACCTTAGGCTTTGTATGACAGTGAAGCAGCACTGTGAGTGGTTCAAGCACACTGGAATATAAAACAGTCATGGCCTGAGAT
GCAGGTGATGCCATTACAGAACCAAATCGTGGCACGTATTGCTGTGTCTCCTCTCAGAGTGACAGTCATAAATACTGTCAAACAATAAAG
GGAGAATGGTGCTGTTTAAAGTCACATCCCTGTAAATTGCAGAATTCAAAAGTGATTATCTCTTTGATCTACTTGCCTCATTTCCCTATC
TTCTCCCCCACGGTATCCTAAACTTTAGACTTCCCACTGTTCTGAAAGGAGACATTGCTCTATGTCTGCCTTCGACCACAGCAAGCCATC
ATCCTCCATTGCTCCCGGGGACTCAAGAGGAATCTGTTTCTCTGCTGTCAACTTCCCATCTGGCTCAGCATAGGGTCACTTTGCCATTAT
GCAAATGGAGATAAAAGCAATTCTGACTGTCCAGGAGCTAATCTGACCGTTCTATTGTGTGGATGACCACATAAGAAGGCAATTTTAGTG
TATTAATCATAGATTATTATAAACTATAAACTTAAGGGCAAGGAGTTTATTACAATGTATCTTTATTAAAACAAAAGGGTGTATAGTGTT
CACAAACTGTGAAAATAGTGTAAGAACTGTACATTGTGAGCTCTGGTTATTTTTCTCTTGTACCATAGAAAAATGTATAAAAATTATCAA
AAAGCTAATGTGCAGGGATATTGCCTTATTTGTCTGTAAAAAATGGAGCTCAGTAACATAACTGCTTCTTGGAGCTTTGGAATATTTTAT
CCTGTATTCTTGTTTGAATTCCTCCTCTATTTAAGATATATACATGGAATCGAAGTGTTTATGTAATAGTTCTATCCTTTTGCCTGCAGG
TCAGTTGTAATAAATCTAGGATGTGATGATGACTTTGTAATTTGATTTTCTGAAATCAGACCCTGAGAGGGGAAAATCTTAAAGTAAATT

>58690_58690_6_NF1-MAP2K4_NF1_chr17_29509683_ENST00000431387_MAP2K4_chr17_12028611_ENST00000415385_length(amino acids)=467AA_BP=339
MGACTPQTLSLPLPSPQPPLPALFPAQGAGPPFPPPPPGRGEDMAAHRPVEWVQAVVSRFDEQLPIKTGQQNTHTKVSTEHNKECLINIS
KYKFSLVISGLTTILKNVNNMRIFGEAAEKNLYLSQLIILDTLEKCLAGQPKDTMRLDETMLVKQLLPEICHFLHTCREGNQHAAELRNS
ASGVLFSLSCNNFNAVFSRISTRLQELTVCSEDNVDVHDIELLQYINVDCAKLKRLLKETAFKFKALKKVAQLAVINSLEKAFWNWVENY
PDEFTKLYQIPQTDMAECAEKLFDLVDGFAESTKRKAAVWPLQIILLILCPEIIQDISKDVVDENNMNKPERIDPSASRQGYDVRSDVWS
LGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NF1-MAP2K4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NF1-MAP2K4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NF1-MAP2K4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource