|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:NF2-MORC2 (FusionGDB2 ID:58728) |
Fusion Gene Summary for NF2-MORC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: NF2-MORC2 | Fusion gene ID: 58728 | Hgene | Tgene | Gene symbol | NF2 | MORC2 | Gene ID | 4771 | 22880 |
| Gene name | neurofibromin 2 | MORC family CW-type zinc finger 2 | |
| Synonyms | ACN|BANF|SCH | CMT2Z|ZCW3|ZCWCC1 | |
| Cytomap | 22q12.2 | 22q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | merlinmoesin-ezrin-radixin likemoesin-ezrin-radixin-like proteinmoesin-ezrin-radizin-like proteinneurofibromin 2 (bilateral acoustic neuroma)schwannomerlinschwannomin | ATPase MORC2zinc finger CW-type coiled-coil domain protein 1 | |
| Modification date | 20200322 | 20200313 | |
| UniProtAcc | P35240 | Q9Y6X9 | |
| Ensembl transtripts involved in fusion gene | ENST00000334961, ENST00000338641, ENST00000347330, ENST00000353887, ENST00000361166, ENST00000361452, ENST00000361676, ENST00000397789, ENST00000403435, ENST00000403999, ENST00000413209, | ENST00000215862, ENST00000469915, ENST00000397641, | |
| Fusion gene scores | * DoF score | 15 X 11 X 7=1155 | 5 X 5 X 5=125 |
| # samples | 18 | 5 | |
| ** MAII score | log2(18/1155*10)=-2.68182403997375 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: NF2 [Title/Abstract] AND MORC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | NF2(30000101)-MORC2(31346431), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | NF2-MORC2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NF2-MORC2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. NF2-MORC2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | NF2 | GO:0008285 | negative regulation of cell proliferation | 12444102|20178741 |
| Hgene | NF2 | GO:0022408 | negative regulation of cell-cell adhesion | 17210637 |
| Hgene | NF2 | GO:0042532 | negative regulation of tyrosine phosphorylation of STAT protein | 12444102 |
| Hgene | NF2 | GO:0046426 | negative regulation of JAK-STAT cascade | 12444102 |
| Tgene | MORC2 | GO:0006338 | chromatin remodeling | 23260667 |
| Tgene | MORC2 | GO:0006974 | cellular response to DNA damage stimulus | 23260667 |
| Tgene | MORC2 | GO:0045814 | negative regulation of gene expression, epigenetic | 28581500|29211708 |
| Tgene | MORC2 | GO:0090309 | positive regulation of methylation-dependent chromatin silencing | 28581500|29211708 |
| Fusion gene breakpoints across NF2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across MORC2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-85-8048-01A | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
Top |
Fusion Gene ORF analysis for NF2-MORC2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000334961 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000338641 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000347330 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000353887 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000361166 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000361452 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000361676 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000397789 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000403435 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000403999 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-5UTR | ENST00000413209 | ENST00000215862 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000334961 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000338641 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000347330 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000353887 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000361166 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000361452 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000361676 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000397789 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000403435 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000403999 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| 5CDS-intron | ENST00000413209 | ENST00000469915 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000334961 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000338641 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000347330 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000353887 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000361166 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000361452 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000361676 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000397789 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000403435 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000403999 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| Frame-shift | ENST00000413209 | ENST00000397641 | NF2 | chr22 | 30000101 | + | MORC2 | chr22 | 31346431 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for NF2-MORC2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for NF2-MORC2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30000101/:31346431) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| NF2 | MORC2 |
| FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}. | FUNCTION: Essential for epigenetic silencing by the HUSH (human silencing hub) complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (PubMed:28581500, PubMed:29440755). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (PubMed:29211708). During DNA damage response, regulates chromatin remodeling through ATP hydrolysis. Upon DNA damage, is phosphorylated by PAK1, both colocalize to chromatin and induce H2AX expression. ATPase activity is required and dependent of phosphorylation by PAK1 and presence of DNA (PubMed:23260667). Recruits histone deacetylases, such as HDAC4, to promoter regions, causing local histone H3 deacetylation and transcriptional repression of genes such as CA9 (PubMed:20225202, PubMed:20110259). Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). {ECO:0000269|PubMed:20110259, ECO:0000269|PubMed:20225202, ECO:0000269|PubMed:23260667, ECO:0000269|PubMed:24286864, ECO:0000269|PubMed:28581500, ECO:0000269|PubMed:29211708, ECO:0000269|PubMed:29440755}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for NF2-MORC2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
Top |
Fusion Gene PPI Analysis for NF2-MORC2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for NF2-MORC2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for NF2-MORC2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies