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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NF2-MTMR3 (FusionGDB2 ID:58729)

Fusion Gene Summary for NF2-MTMR3

check button Fusion gene summary
Fusion gene informationFusion gene name: NF2-MTMR3
Fusion gene ID: 58729
HgeneTgene
Gene symbol

NF2

MTMR3

Gene ID

4771

8897

Gene nameneurofibromin 2myotubularin related protein 3
SynonymsACN|BANF|SCHFYVE-DSP1|ZFYVE10
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionmerlinmoesin-ezrin-radixin likemoesin-ezrin-radixin-like proteinmoesin-ezrin-radizin-like proteinneurofibromin 2 (bilateral acoustic neuroma)schwannomerlinschwannominmyotubularin-related protein 3FYVE (Fab1 YGLO23 Vsp27 EEA1 domain) dual-specificity protein phosphataseFYVE domain-containing dual specificity protein phosphatase 1phosphatidylinositol-3,5-bisphosphate 3-phosphatasephosphatidylinositol-3-phosphate pho
Modification date2020032220200313
UniProtAcc

P35240

Q13615

Ensembl transtripts involved in fusion geneENST00000334961, ENST00000338641, 
ENST00000347330, ENST00000353887, 
ENST00000361166, ENST00000361452, 
ENST00000361676, ENST00000397789, 
ENST00000403435, ENST00000403999, 
ENST00000413209, 		ENST00000415511, 
ENST00000323630, ENST00000333027, 
ENST00000351488, ENST00000401950, 
ENST00000406629, 
Fusion gene scores* DoF score15 X 11 X 7=11558 X 8 X 5=320
# samples 189
** MAII scorelog2(18/1155*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/320*10)=-1.83007499855769
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NF2 [Title/Abstract] AND MTMR3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNF2(30000101)-MTMR3(30353025), # samples:2
MTMR3(30279348)-NF2(30067814), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNF2

GO:0008285

negative regulation of cell proliferation

12444102|20178741

HgeneNF2

GO:0022408

negative regulation of cell-cell adhesion

17210637

HgeneNF2

GO:0042532

negative regulation of tyrosine phosphorylation of STAT protein

12444102

HgeneNF2

GO:0046426

negative regulation of JAK-STAT cascade

12444102

TgeneMTMR3

GO:0006470

protein dephosphorylation

10733931

TgeneMTMR3

GO:0046856

phosphatidylinositol dephosphorylation

10900271|11676921

TgeneMTMR3

GO:0060304

regulation of phosphatidylinositol dephosphorylation

16787938

TgeneMTMR3

GO:1904562

phosphatidylinositol 5-phosphate metabolic process

11676921


check buttonFusion gene breakpoints across NF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MTMR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-34-A5IX-01ANF2chr22

30000101

+MTMR3chr22

30353025

+
ChimerDB4LUSCTCGA-34-A5IXNF2chr22

30000101

+MTMR3chr22

30353025

+
ChiTaRS5.0N/ABF687576NF2chr22

30045574

+MTMR3chr22

30378206

+


Top

Fusion Gene ORF analysis for NF2-MTMR3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000334961ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000338641ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000347330ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000353887ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000361166ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000361452ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000361676ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000397789ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000403435ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000403999ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-3UTRENST00000413209ENST00000415511NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000334961ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000334961ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000334961ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000334961ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000338641ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000338641ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000338641ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000338641ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000347330ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000347330ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000347330ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000347330ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000353887ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000353887ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000353887ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000353887ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361166ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361166ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361166ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361166ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361452ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361452ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361452ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361452ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361676ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361676ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361676ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000361676ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000397789ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000397789ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000397789ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000397789ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000403435ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000403435ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000403435ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000403435ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000403999ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000403999ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000403999ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000403999ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000413209ENST00000323630NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000413209ENST00000333027NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000413209ENST00000351488NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-5UTRENST00000413209ENST00000401950NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000334961ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000338641ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000347330ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000353887ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000361166ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000361452ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000361676ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000397789ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000403435ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000403999ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
5CDS-intronENST00000413209ENST00000406629NF2chr22

30000101

+MTMR3chr22

30353025

+
intron-intronENST00000334961ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000334961ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000334961ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000334961ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000334961ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000334961ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000338641ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000338641ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000338641ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000338641ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000338641ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000338641ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000347330ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000347330ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000347330ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000347330ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000347330ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000347330ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000353887ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000353887ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000353887ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000353887ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000353887ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000353887ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361166ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361166ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361166ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361166ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361166ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361166ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361452ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361452ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361452ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361452ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361452ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361452ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361676ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361676ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361676ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361676ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361676ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000361676ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000397789ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000397789ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000397789ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000397789ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000397789ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000397789ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403435ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403435ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403435ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403435ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403435ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403435ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403999ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403999ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403999ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403999ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403999ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000403999ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000413209ENST00000323630NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000413209ENST00000333027NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000413209ENST00000351488NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000413209ENST00000401950NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000413209ENST00000406629NF2chr22

30045574

+MTMR3chr22

30378206

+
intron-intronENST00000413209ENST00000415511NF2chr22

30045574

+MTMR3chr22

30378206

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for NF2-MTMR3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NF2chr2230000101+MTMR3chr2230353024+2.48E-111
NF2chr2230000101+MTMR3chr2230353024+2.48E-111
NF2chr2230000101+MTMR3chr2230353024+2.48E-111
NF2chr2230000101+MTMR3chr2230353024+2.48E-111

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for NF2-MTMR3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:30000101/:30353025)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NF2

P35240

MTMR3

Q13615

FUNCTION: Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. {ECO:0000269|PubMed:20159598, ECO:0000269|PubMed:20178741, ECO:0000269|PubMed:21167305}.FUNCTION: Phosphatase that acts on lipids with a phosphoinositol headgroup (PubMed:11676921). Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (PubMed:11676921). May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11676921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NF2-MTMR3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NF2-MTMR3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NF2-MTMR3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NF2-MTMR3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource