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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFASC-GLYR1 (FusionGDB2 ID:58741)

Fusion Gene Summary for NFASC-GLYR1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFASC-GLYR1
Fusion gene ID: 58741
HgeneTgene
Gene symbol

NFASC

GLYR1

Gene ID

23114

84656

Gene nameneurofascinglyoxylate reductase 1 homolog
SynonymsNEDCPMD|NF|NRCAMLBM045|HIBDL|N-PAC|NP60|hNDF
Cytomap

1q32.1

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionneurofascinneurofascin homologneurofascin isoform 140putative oxidoreductase GLYR13-hydroxyisobutyrate dehydrogenase-like proteincytokine-like nuclear factor n-pacnuclear protein 60 kDanuclear protein 60kDanuclear protein NP60nuclear protein of 60 kDanucleosome-destabilizing factor
Modification date2020031320200313
UniProtAcc

O94856

Q49A26

Ensembl transtripts involved in fusion geneENST00000338515, ENST00000338586, 
ENST00000339876, ENST00000360049, 
ENST00000367169, ENST00000367170, 
ENST00000367171, ENST00000367172, 
ENST00000401399, ENST00000403080, 
ENST00000404076, ENST00000539706, 
ENST00000404907, ENST00000495396, 
ENST00000513543, 		ENST00000321919, 
ENST00000381983, ENST00000436648, 
ENST00000591451, ENST00000586901, 
Fusion gene scores* DoF score16 X 10 X 4=6409 X 6 X 7=378
# samples 2110
** MAII scorelog2(21/640*10)=-1.60768257722124
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFASC [Title/Abstract] AND GLYR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFASC(204889868)-GLYR1(4896211), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLYR1

GO:0035066

positive regulation of histone acetylation

29759984

TgeneGLYR1

GO:0045944

positive regulation of transcription by RNA polymerase II

29759984


check buttonFusion gene breakpoints across NFASC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across GLYR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-12-1597-01BNFASCchr1

204889868

+GLYR1chr16

4896211

-


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Fusion Gene ORF analysis for NFASC-GLYR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000338515ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000338515ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000338515ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000338515ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000338586ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000338586ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000338586ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000338586ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000339876ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000339876ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000339876ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000339876ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000360049ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000360049ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000360049ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000360049ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367169ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367169ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367169ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367169ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367170ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367170ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367170ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367170ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367171ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367171ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367171ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367171ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367172ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367172ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367172ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000367172ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000401399ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000401399ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000401399ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000401399ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000403080ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000403080ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000403080ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000403080ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000404076ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000404076ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000404076ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000404076ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000539706ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000539706ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000539706ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-3CDSENST00000539706ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000338515ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000338586ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000339876ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000360049ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000367169ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000367170ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000367171ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000367172ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000401399ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000403080ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000404076ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
5UTR-intronENST00000539706ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000404907ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000404907ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000404907ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000404907ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000495396ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000495396ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000495396ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000495396ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000513543ENST00000321919NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000513543ENST00000381983NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000513543ENST00000436648NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-3CDSENST00000513543ENST00000591451NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-intronENST00000404907ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-intronENST00000495396ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-
intron-intronENST00000513543ENST00000586901NFASCchr1

204889868

+GLYR1chr16

4896211

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for NFASC-GLYR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NFASC-GLYR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:204889868/:4896211)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFASC

O94856

GLYR1

Q49A26

FUNCTION: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. {ECO:0000250}.FUNCTION: Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984). Facilitates Pol II transcription through nucleosomes (PubMed:29759984). Binds DNA (in vitro) (PubMed:29759984). Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (PubMed:20850016). Promotes KDM1B demethylase activity (PubMed:23260659). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). Putative oxidoreductase (PubMed:23260659). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for NFASC-GLYR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NFASC-GLYR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFASC-GLYR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFASC-GLYR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource