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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NFASC-LRRN2 (FusionGDB2 ID:58742)

Fusion Gene Summary for NFASC-LRRN2

Fusion gene summary

Fusion gene information	Fusion gene name: NFASC-LRRN2
	Fusion gene ID: 58742
		Hgene	Tgene
	Gene symbol	NFASC	LRRN2
	Gene ID	23114	10446
	Gene name	neurofascin	leucine rich repeat neuronal 2
	Synonyms	NEDCPMD\|NF\|NRCAML	FIGLER7\|GAC1\|LRANK1\|LRRN5
	Cytomap	1q32.1	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	neurofascinneurofascin homologneurofascin isoform 140	leucine-rich repeat neuronal protein 2fibronectin type III, immunoglobulin and leucine rich repeat domain 7glioma amplified on chromosome 1 proteinleucine rich and ankyrin repeats 1leucine rich repeat neuronal 5leucine-rich repeat neuronal protein 5
	Modification date	20200313	20200313
	UniProtAcc	O94856	O75325
	Ensembl transtripts involved in fusion gene	ENST00000338515, ENST00000338586, ENST00000339876, ENST00000360049, ENST00000367169, ENST00000367170, ENST00000367171, ENST00000367172, ENST00000403080, ENST00000539706, ENST00000401399, ENST00000404076, ENST00000404907, ENST00000495396, ENST00000513543,	ENST00000367175, ENST00000367176, ENST00000367177, ENST00000496057,
Fusion gene scores	* DoF score	16 X 10 X 4=640	5 X 3 X 7=105
	# samples	21	8
	** MAII score	log2(21/640*10)=-1.60768257722124 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/105*10)=-0.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NFASC [Title/Abstract] AND LRRN2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NFASC(204797910)-LRRN2(204589346), # samples:4
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across NFASC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LRRN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-27-1834-01A	NFASC	chr1	204797910	-	LRRN2	chr1	204589346	-
ChimerDB4	GBM	TCGA-27-1834-01A	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
ChimerDB4	GBM	TCGA-27-1834-01A	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
ChimerDB4	GBM	TCGA-27-1834	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-

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Fusion Gene ORF analysis for NFASC-LRRN2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5UTR-5UTR	ENST00000338515	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000338515	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000338515	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000338515	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000338515	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000338586	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000338586	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000338586	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000338586	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000338586	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000339876	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000339876	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000339876	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000339876	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000339876	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000360049	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000360049	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000360049	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000360049	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000360049	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000367169	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367169	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367169	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367169	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367169	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000367170	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367170	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367170	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367170	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367170	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000367171	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367171	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367171	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367171	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367171	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000367172	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367172	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367172	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367172	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000367172	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000403080	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000403080	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000403080	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000403080	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000403080	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-5UTR	ENST00000539706	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000539706	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000539706	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000539706	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
5UTR-5UTR	ENST00000539706	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000338515	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000338515	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000338515	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000338586	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000338586	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000338586	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000339876	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000339876	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000339876	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000360049	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000360049	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000360049	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367169	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367169	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367169	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367170	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367170	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367170	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367171	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367171	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367171	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367172	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367172	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000367172	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000403080	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000403080	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000403080	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000539706	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000539706	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
5UTR-intron	ENST00000539706	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-5UTR	ENST00000401399	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000401399	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000401399	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000401399	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000401399	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-5UTR	ENST00000404076	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000404076	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000404076	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000404076	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000404076	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-5UTR	ENST00000404907	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000404907	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000404907	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000404907	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000404907	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-5UTR	ENST00000495396	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000495396	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000495396	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000495396	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000495396	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-5UTR	ENST00000513543	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000513543	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000513543	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000513543	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204589346	-
intron-5UTR	ENST00000513543	ENST00000496057	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000401399	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000401399	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000401399	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000404076	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000404076	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000404076	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000404907	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000404907	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000404907	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000495396	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000495396	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000495396	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000513543	ENST00000367175	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000513543	ENST00000367176	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-
intron-intron	ENST00000513543	ENST00000367177	NFASC	chr1	204797910	+	LRRN2	chr1	204602374	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for NFASC-LRRN2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NFASC-LRRN2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:204797910/:204589346)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NFASC O94856	LRRN2 O75325
FUNCTION: Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for NFASC-LRRN2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for NFASC-LRRN2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NFASC-LRRN2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NFASC-LRRN2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source