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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFAT5-IST1 (FusionGDB2 ID:58767)

Fusion Gene Summary for NFAT5-IST1

check button Fusion gene summary
Fusion gene informationFusion gene name: NFAT5-IST1
Fusion gene ID: 58767
HgeneTgene
Gene symbol

NFAT5

IST1

Gene ID

10725

9798

Gene namenuclear factor of activated T cells 5IST1 factor associated with ESCRT-III
SynonymsNF-AT5|NFATL1|NFATZ|OREBP|TONEBPCHMP8|OLC1
Cytomap

16q22.1

16q22.2

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor of activated T-cells 5NFAT-like protein 1T-cell transcription factor NFAT5TonE-binding proteinglutamine rich protein H65nuclear factor of activated T-cells 5, tonicity-responsiveosmotic response element-binding proteintonicity-responIST1 homologIST1, ESCRT-III associated factorIST1, endosomal sorting complex required for transport-III componentincreased sodium tolerance 1 homologoverexpressed in lung cancer 1putative MAPK-activating protein PM28
Modification date2020031320200313
UniProtAcc

O94916

P53990

Ensembl transtripts involved in fusion geneENST00000354436, ENST00000432919, 
ENST00000567239, ENST00000349945, 
ENST00000393742, ENST00000566899, 
ENST00000329908, ENST00000378798, 
ENST00000538565, ENST00000538850, 
ENST00000606369, ENST00000378799, 
ENST00000535424, ENST00000541571, 
ENST00000544564, 
Fusion gene scores* DoF score27 X 13 X 19=66698 X 7 X 4=224
# samples 4510
** MAII scorelog2(45/6669*10)=-3.88947354253111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/224*10)=-1.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NFAT5 [Title/Abstract] AND IST1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFAT5(69600277)-IST1(71961517), # samples:2
Anticipated loss of major functional domain due to fusion event.NFAT5-IST1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFAT5

GO:0045944

positive regulation of transcription by RNA polymerase II

11485737

TgeneIST1

GO:0009838

abscission

19129479|19129480

TgeneIST1

GO:0019076

viral release from host cell

19129479

TgeneIST1

GO:0045862

positive regulation of proteolysis

20849418

TgeneIST1

GO:0046745

viral capsid secondary envelopment

19129479


check buttonFusion gene breakpoints across NFAT5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across IST1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1NA-01ANFAT5chr16

69600277

+IST1chr16

71961517

+


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Fusion Gene ORF analysis for NFAT5-IST1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000354436ENST00000329908NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000354436ENST00000378798NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000354436ENST00000538565NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000354436ENST00000538850NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000354436ENST00000606369NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000432919ENST00000329908NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000432919ENST00000378798NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000432919ENST00000538565NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000432919ENST00000538850NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000432919ENST00000606369NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000567239ENST00000329908NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000567239ENST00000378798NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000567239ENST00000538565NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000567239ENST00000538850NFAT5chr16

69600277

+IST1chr16

71961517

+
5CDS-3UTRENST00000567239ENST00000606369NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000349945ENST00000378799NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000349945ENST00000535424NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000349945ENST00000541571NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000349945ENST00000544564NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000393742ENST00000378799NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000393742ENST00000535424NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000393742ENST00000541571NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000393742ENST00000544564NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000566899ENST00000378799NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000566899ENST00000535424NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000566899ENST00000541571NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3CDSENST00000566899ENST00000544564NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000349945ENST00000329908NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000349945ENST00000378798NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000349945ENST00000538565NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000349945ENST00000538850NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000349945ENST00000606369NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000393742ENST00000329908NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000393742ENST00000378798NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000393742ENST00000538565NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000393742ENST00000538850NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000393742ENST00000606369NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000566899ENST00000329908NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000566899ENST00000378798NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000566899ENST00000538565NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000566899ENST00000538850NFAT5chr16

69600277

+IST1chr16

71961517

+
5UTR-3UTRENST00000566899ENST00000606369NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000354436ENST00000378799NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000354436ENST00000535424NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000354436ENST00000541571NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000432919ENST00000378799NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000432919ENST00000535424NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000432919ENST00000541571NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000567239ENST00000378799NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000567239ENST00000535424NFAT5chr16

69600277

+IST1chr16

71961517

+
Frame-shiftENST00000567239ENST00000541571NFAT5chr16

69600277

+IST1chr16

71961517

+
In-frameENST00000354436ENST00000544564NFAT5chr16

69600277

+IST1chr16

71961517

+
In-frameENST00000432919ENST00000544564NFAT5chr16

69600277

+IST1chr16

71961517

+
In-frameENST00000567239ENST00000544564NFAT5chr16

69600277

+IST1chr16

71961517

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000432919NFAT5chr1669600277+ENST00000544564IST1chr1671961517+155812813881335315
ENST00000354436NFAT5chr1669600277+ENST00000544564IST1chr1671961517+66839196590164
ENST00000567239NFAT5chr1669600277+ENST00000544564IST1chr1671961517+59031318512164

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000432919ENST00000544564NFAT5chr1669600277+IST1chr1671961517+0.243828250.75617176
ENST00000354436ENST00000544564NFAT5chr1669600277+IST1chr1671961517+0.0433783530.9566217
ENST00000567239ENST00000544564NFAT5chr1669600277+IST1chr1671961517+0.0185868130.98141325

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Fusion Genomic Features for NFAT5-IST1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
NFAT5chr1669600277+IST1chr1671961516+6.00E-060.99999404
NFAT5chr1669600277+IST1chr1671961516+6.00E-060.99999404

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for NFAT5-IST1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:69600277/chr16:71961517)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFAT5

O94916

IST1

P53990

FUNCTION: Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity (PubMed:10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed:22266867). Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed:10377394). {ECO:0000269|PubMed:10051678, ECO:0000269|PubMed:10377394, ECO:0000269|PubMed:22266867}.FUNCTION: ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888). {ECO:0000269|PubMed:19129479, ECO:0000269|PubMed:19129480, ECO:0000269|PubMed:23897888, ECO:0000269|PubMed:26040712}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneIST1chr16:69600277chr16:71961517ENST00000329908810321_332299361.0MotifNote=Type-2 MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST00000329908810351_361299361.0MotifNote=MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST0000037879879321_332269336.0MotifNote=Type-2 MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST0000037879879351_361269336.0MotifNote=MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST00000378799810321_332300367.0MotifNote=Type-2 MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST00000378799810351_361300367.0MotifNote=MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST00000535424810321_332313380.0MotifNote=Type-2 MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST00000535424810351_361313380.0MotifNote=MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST00000541571911321_332300367.0MotifNote=Type-2 MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST00000541571911351_361300367.0MotifNote=MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST000005445641012321_332300367.0MotifNote=Type-2 MIT-interacting motif
TgeneIST1chr16:69600277chr16:71961517ENST000005445641012351_361300367.0MotifNote=MIT-interacting motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFAT5chr16:69600277chr16:71961517ENST00000349945+1161248_126603792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000349945+11669_10003792.6666666666665Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr16:71961517ENST00000349945+116739_74303792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000349945+116879_88803792.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000349945+116966_97103792.6666666666665Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr16:71961517ENST00000354436+1141248_1266244170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000354436+11469_100244170.666666666667Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr16:71961517ENST00000354436+114739_743244170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000354436+114879_888244170.666666666667Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000354436+114966_971244170.666666666667Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr16:71961517ENST00000393742+1151248_126604169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000393742+11569_10004169.333333333333Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr16:71961517ENST00000393742+115739_74304169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000393742+115879_88804169.333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000393742+115966_97104169.333333333333Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr16:71961517ENST00000432919+1151248_1266243886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000432919+11569_100243886.6666666666665Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr16:71961517ENST00000432919+115739_743243886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000432919+115879_888243886.6666666666665Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000432919+115966_971243886.6666666666665Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr16:71961517ENST00000566899+1141248_126601456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000566899+11469_10001456.0Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr16:71961517ENST00000566899+114739_74301456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000566899+114879_88801456.0Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000566899+114966_97101456.0Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr16:71961517ENST00000567239+1151248_1266241938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000567239+11569_100241938.3333333333333Compositional biasNote=Ser-rich
HgeneNFAT5chr16:69600277chr16:71961517ENST00000567239+115739_743241938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000567239+115879_888241938.3333333333333Compositional biasNote=Poly-Gln
HgeneNFAT5chr16:69600277chr16:71961517ENST00000567239+115966_971241938.3333333333333Compositional biasNote=Poly-Thr
HgeneNFAT5chr16:69600277chr16:71961517ENST00000349945+116293_30003792.6666666666665DNA binding.
HgeneNFAT5chr16:69600277chr16:71961517ENST00000354436+114293_300244170.666666666667DNA binding.
HgeneNFAT5chr16:69600277chr16:71961517ENST00000393742+115293_30004169.333333333333DNA binding.
HgeneNFAT5chr16:69600277chr16:71961517ENST00000432919+115293_300243886.6666666666665DNA binding.
HgeneNFAT5chr16:69600277chr16:71961517ENST00000566899+114293_30001456.0DNA binding.
HgeneNFAT5chr16:69600277chr16:71961517ENST00000567239+115293_300241938.3333333333333DNA binding.
HgeneNFAT5chr16:69600277chr16:71961517ENST00000349945+116264_44303792.6666666666665DomainRHD
HgeneNFAT5chr16:69600277chr16:71961517ENST00000354436+114264_443244170.666666666667DomainRHD
HgeneNFAT5chr16:69600277chr16:71961517ENST00000393742+115264_44304169.333333333333DomainRHD
HgeneNFAT5chr16:69600277chr16:71961517ENST00000432919+115264_443243886.6666666666665DomainRHD
HgeneNFAT5chr16:69600277chr16:71961517ENST00000566899+114264_44301456.0DomainRHD
HgeneNFAT5chr16:69600277chr16:71961517ENST00000567239+115264_443241938.3333333333333DomainRHD


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Fusion Gene Sequence for NFAT5-IST1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58767_58767_1_NFAT5-IST1_NFAT5_chr16_69600277_ENST00000354436_IST1_chr16_71961517_ENST00000544564_length(transcript)=668nt_BP=391nt
GCGGCGGTGGCGGCGACCGTCAGTTTTCGCTGAGGAGAAACACGAAACGGACCCTTTGGCTCTCCCCCTTCCCCTTCCCCGTCCTGAACC
CCTCTCCTGGTCACCGAGAATCAGTCCCCGTGGAGTTCCCCCTCCACCTCGCCATCGTTTCCTCGGTCCTCGGCCCAGTGGAAGTCACTA
CCCTCGAGGAGGAGGCAGCGGCAGCCGCCCTCGCGTCGCCGCCCCCGGTTCGGTGCCCGCGGTCCCGGAGAGGAGGTGCCGCCGCCACCG
CCGCTCCCCCCCTCCCGCTGCCCTCGGGCCGGGCTGGGTCGAGCTGCGATGCCCTCGGACTTCATCTCATTGCTCAGCGCGGACCTAGAC
CTGGAATCGCCCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCAGAAGCCTCTGCAAAGCTTCCTTCCAGACCTGCAGATAACTAT
GACAACTTTGTCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCAACTGCATCTGCTGGTGCCAGCACCTCAGCATCTGAAGACATT
GACTTTGATGATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACATAGGTCTCTTAAACCAGGCAACTTTCACGTTTTGGGAGTTGA

>58767_58767_1_NFAT5-IST1_NFAT5_chr16_69600277_ENST00000354436_IST1_chr16_71961517_ENST00000544564_length(amino acids)=164AA_BP=93
MVTENQSPWSSPSTSPSFPRSSAQWKSLPSRRRQRQPPSRRRPRFGARGPGEEVPPPPPLPPSRCPRAGLGRAAMPSDFISLLSADLDLE

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>58767_58767_2_NFAT5-IST1_NFAT5_chr16_69600277_ENST00000432919_IST1_chr16_71961517_ENST00000544564_length(transcript)=1558nt_BP=1281nt
TGCAACGGAAACTTTTGGCTCCACGAACAGAAAAGCAAGAGCAAAAACTCAGTTAAATGCGTTCTTCCTCCATCTTTGCCTAGTCCAAAA
GGAAAAAAAAAGAAACAGAAAAAAGAAAAACTGTTTGGAAGAGTAGCGTTGAGGTTTGCTTTTTACCTGTTTTTCCTCTAGAACAGCCAG
GTGGATTCACATGATCCAATTTTTTAATTGTCTTCTATGTCCCACTCCGAATAACCCGGATGCCCCAGCACAATCAGAGAGATCGTTTTT
TTTAAAAAAAATTTCAGCCTCCAAAGGTAGGAGGGGAGTGTTAGGGGAGAAAGTACTTTAATTAAAAATCAATAACTCGAGGTTTTTGGG
ATACGGTTTGCCATTTCCTAATTAAGAAATGGGTTTGACAGTCCCTTTGTACACACTGCTATGCAAACCCCAAAGGGTTGGCGGCTGTCC
GGGCGATGACACTCCGGTCCCCTGCGAGACCCCGGGCCAGCCAGGCCCGTCCGCCGCCGGCCTCTGGGGTCCGTCCCCGGCTCGCGCAGA
CCTCTCGCTTCTCTCGGCTCTGTCTCCTGCGCTCAGCTCTGCTCGGGGCCGGCCGCCTCAGGCTCGCCGCCACCAGGTCGTTGCAAATAC
CTTTTCCCTCCCCGGGGCCCCAGCGCGCGGCCACCTCCCAGCCTCCCCCCCTCCCACCCTGGCAGCGGGGCCCTTTCCCGGCTCAGGAAC
AGCAGCAGCCCGGGCCGCGCCGGCAGGAAGCGAGGCCCATGTTGCTGCTGTTCCCTGGCGCGCCTCCCCGCCCTCCGGGGGCCGCCACGG
CTCTTCCGCGCTCCCGGGCACCCCCCTCCGCGCCTGCGCTGTGCCCCACGGGGGCGGGGCTCAGATTCCTGTCAGCGGCGGCGGCGGTGG
CGGCGACCGTCAGTTTTCGCTGAGGAGAAACACGAAACGGACCCTTTGGCTCTCCCCCTTCCCCTTCCCCGTCCTGAACCCCTCTCCTGG
TCACCGAGAATCAGTCCCCGTGGAGTTCCCCCTCCACCTCGCCATCGTTTCCTCGGTCCTCGGCCCAGTGGAAGTCACTACCCTCGAGGA
GGAGGCAGCGGCAGCCGCCCTCGCGTCGCCGCCCCCGGTTCGGTGCCCGCGGTCCCGGAGAGGAGGTGCCGCCGCCACCGCCGCTCCCCC
CCTCCCGCTGCCCTCGGGCCGGGCTGGGTCGAGCTGCGATGCCCTCGGACTTCATCTCATTGCTCAGCGCGGACCTAGACCTGGAATCGC
CCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCAGAAGCCTCTGCAAAGCTTCCTTCCAGACCTGCAGATAACTATGACAACTTTG
TCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCAACTGCATCTGCTGGTGCCAGCACCTCAGCATCTGAAGACATTGACTTTGATG
ATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACATAGGTCTCTTAAACCAGGCAACTTTCACGTTTTGGGAGTTGAGACTGAGCAA

>58767_58767_2_NFAT5-IST1_NFAT5_chr16_69600277_ENST00000432919_IST1_chr16_71961517_ENST00000544564_length(amino acids)=315AA_BP=295
MGLTVPLYTLLCKPQRVGGCPGDDTPVPCETPGQPGPSAAGLWGPSPARADLSLLSALSPALSSARGRPPQARRHQVVANTFSLPGAPAR
GHLPASPPPTLAAGPFPGSGTAAARAAPAGSEAHVAAVPWRASPPSGGRHGSSALPGTPLRACAVPHGGGAQIPVSGGGGGGDRQFSLRR
NTKRTLWLSPFPFPVLNPSPGHRESVPVEFPLHLAIVSSVLGPVEVTTLEEEAAAAALASPPPVRCPRSRRGGAAATAAPPLPLPSGRAG

--------------------------------------------------------------
>58767_58767_3_NFAT5-IST1_NFAT5_chr16_69600277_ENST00000567239_IST1_chr16_71961517_ENST00000544564_length(transcript)=590nt_BP=313nt
CCGTCCTGAACCCCTCTCCTGGTCACCGAGAATCAGTCCCCGTGGAGTTCCCCCTCCACCTCGCCATCGTTTCCTCGGTCCTCGGCCCAG
TGGAAGTCACTACCCTCGAGGAGGAGGCAGCGGCAGCCGCCCTCGCGTCGCCGCCCCCGGTTCGGTGCCCGCGGTCCCGGAGAGGAGGTG
CCGCCGCCACCGCCGCTCCCCCCCTCCCGCTGCCCTCGGGCCGGGCTGGGTCGAGCTGCGATGCCCTCGGACTTCATCTCATTGCTCAGC
GCGGACCTAGACCTGGAATCGCCCAAGTCCCTCTACTCGCGAGGTCCTGGACCCAAGCCAGAAGCCTCTGCAAAGCTTCCTTCCAGACCT
GCAGATAACTATGACAACTTTGTCCTACCAGAGTTGCCATCTGTGCCAGACACACTACCAACTGCATCTGCTGGTGCCAGCACCTCAGCA
TCTGAAGACATTGACTTTGATGATCTTTCCCGGAGGTTTGAAGAGCTGAAAAAGAAAACATAGGTCTCTTAAACCAGGCAACTTTCACGT

>58767_58767_3_NFAT5-IST1_NFAT5_chr16_69600277_ENST00000567239_IST1_chr16_71961517_ENST00000544564_length(amino acids)=164AA_BP=93
MVTENQSPWSSPSTSPSFPRSSAQWKSLPSRRRQRQPPSRRRPRFGARGPGEEVPPPPPLPPSRCPRAGLGRAAMPSDFISLLSADLDLE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NFAT5-IST1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneIST1chr16:69600277chr16:71961517ENST00000329908810348_364299.0361.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
TgeneIST1chr16:69600277chr16:71961517ENST0000037879879348_364269.3333333333333336.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
TgeneIST1chr16:69600277chr16:71961517ENST00000378799810348_364300.3333333333333367.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
TgeneIST1chr16:69600277chr16:71961517ENST00000535424810348_364313.3333333333333380.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
TgeneIST1chr16:69600277chr16:71961517ENST00000541571911348_364300.3333333333333367.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8
TgeneIST1chr16:69600277chr16:71961517ENST000005445641012348_364300.3333333333333367.0VPS4A%2C VTA1%2C MITD1 STAMBP and USP8


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneIST1chr16:69600277chr16:71961517ENST000003299088101_168299.0361.0CHMP1A and CHMP1B
TgeneIST1chr16:69600277chr16:71961517ENST00000378798791_168269.3333333333333336.0CHMP1A and CHMP1B
TgeneIST1chr16:69600277chr16:71961517ENST000003787998101_168300.3333333333333367.0CHMP1A and CHMP1B
TgeneIST1chr16:69600277chr16:71961517ENST000005354248101_168313.3333333333333380.0CHMP1A and CHMP1B
TgeneIST1chr16:69600277chr16:71961517ENST000005415719111_168300.3333333333333367.0CHMP1A and CHMP1B
TgeneIST1chr16:69600277chr16:71961517ENST0000054456410121_168300.3333333333333367.0CHMP1A and CHMP1B
TgeneIST1chr16:69600277chr16:71961517ENST0000032990881064_279299.0361.0VPS37B
TgeneIST1chr16:69600277chr16:71961517ENST000003787987964_279269.3333333333333336.0VPS37B
TgeneIST1chr16:69600277chr16:71961517ENST0000037879981064_279300.3333333333333367.0VPS37B
TgeneIST1chr16:69600277chr16:71961517ENST0000053542481064_279313.3333333333333380.0VPS37B
TgeneIST1chr16:69600277chr16:71961517ENST0000054157191164_279300.3333333333333367.0VPS37B
TgeneIST1chr16:69600277chr16:71961517ENST00000544564101264_279300.3333333333333367.0VPS37B
TgeneIST1chr16:69600277chr16:71961517ENST00000329908810190_364299.0361.0VTA1
TgeneIST1chr16:69600277chr16:71961517ENST0000037879879190_364269.3333333333333336.0VTA1
TgeneIST1chr16:69600277chr16:71961517ENST00000378799810190_364300.3333333333333367.0VTA1
TgeneIST1chr16:69600277chr16:71961517ENST00000535424810190_364313.3333333333333380.0VTA1
TgeneIST1chr16:69600277chr16:71961517ENST00000541571911190_364300.3333333333333367.0VTA1
TgeneIST1chr16:69600277chr16:71961517ENST000005445641012190_364300.3333333333333367.0VTA1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFAT5-IST1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFAT5-IST1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource