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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:NFE2L2-PDE11A (FusionGDB2 ID:58845)

Fusion Gene Summary for NFE2L2-PDE11A

Fusion gene summary

Fusion gene information	Fusion gene name: NFE2L2-PDE11A
	Fusion gene ID: 58845
		Hgene	Tgene
	Gene symbol	NFE2L2	PDE11A
	Gene ID	4780	50940
	Gene name	nuclear factor, erythroid 2 like 2	phosphodiesterase 11A
	Synonyms	HEBP1\|IMDDHH\|NRF2\|Nrf-2	PPNAD2
	Cytomap	2q31.2	2q31.2
	Type of gene	protein-coding	protein-coding
	Description	nuclear factor erythroid 2-related factor 2nuclear factor erythroid-derived 2-like 2	dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11AcAMP and cGMP cyclic nucleotide phosphodiesterase 11A
	Modification date	20200329	20200313
	UniProtAcc	Q16236	.
	Ensembl transtripts involved in fusion gene	ENST00000397062, ENST00000397063, ENST00000446151, ENST00000464747, ENST00000423513,	ENST00000497003, ENST00000389683, ENST00000409504, ENST00000449286, ENST00000450799, ENST00000286063, ENST00000358450,
Fusion gene scores	* DoF score	18 X 18 X 9=2916	8 X 5 X 6=240
	# samples	29	11
	** MAII score	log2(29/2916*10)=-3.329865914312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/240*10)=-1.12553088208386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: NFE2L2 [Title/Abstract] AND PDE11A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NFE2L2(178097120)-PDE11A(178634101), # samples:2
Anticipated loss of major functional domain due to fusion event.	NFE2L2-PDE11A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. NFE2L2-PDE11A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. NFE2L2-PDE11A seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. NFE2L2-PDE11A seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. NFE2L2-PDE11A seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	NFE2L2	GO:0010499	proteasomal ubiquitin-independent protein catabolic process	19424503
Hgene	NFE2L2	GO:0016567	protein ubiquitination	15983046
Hgene	NFE2L2	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	15983046
Hgene	NFE2L2	GO:0045944	positive regulation of transcription by RNA polymerase II	17015834
Hgene	NFE2L2	GO:0071498	cellular response to fluid shear stress	25190803

Fusion gene breakpoints across NFE2L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PDE11A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-18-4721-01A	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
ChimerDB4	LUSC	TCGA-18-4721	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
ChimerDB4	OV	TCGA-61-1724-01A	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
ChimerDB4	OV	TCGA-61-1724-01A	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
ChimerDB4	OV	TCGA-61-1724	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
ChimerDB4	OV	TCGA-61-1724	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-

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Fusion Gene ORF analysis for NFE2L2-PDE11A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000397062	ENST00000497003	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-5UTR	ENST00000397062	ENST00000497003	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
5CDS-5UTR	ENST00000397062	ENST00000497003	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
5CDS-5UTR	ENST00000397063	ENST00000497003	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-5UTR	ENST00000446151	ENST00000497003	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-5UTR	ENST00000464747	ENST00000497003	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000397062	ENST00000389683	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000397062	ENST00000389683	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
5CDS-intron	ENST00000397062	ENST00000389683	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
5CDS-intron	ENST00000397062	ENST00000409504	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000397062	ENST00000409504	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
5CDS-intron	ENST00000397062	ENST00000409504	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
5CDS-intron	ENST00000397062	ENST00000449286	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000397062	ENST00000449286	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
5CDS-intron	ENST00000397062	ENST00000449286	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
5CDS-intron	ENST00000397062	ENST00000450799	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000397062	ENST00000450799	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
5CDS-intron	ENST00000397062	ENST00000450799	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
5CDS-intron	ENST00000397063	ENST00000389683	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000397063	ENST00000409504	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000397063	ENST00000449286	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000397063	ENST00000450799	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000446151	ENST00000389683	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000446151	ENST00000409504	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000446151	ENST00000449286	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000446151	ENST00000450799	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000464747	ENST00000389683	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000464747	ENST00000409504	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000464747	ENST00000449286	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5CDS-intron	ENST00000464747	ENST00000450799	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
5UTR-3CDS	ENST00000397063	ENST00000286063	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000397063	ENST00000286063	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000397063	ENST00000358450	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000397063	ENST00000358450	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000423513	ENST00000286063	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000423513	ENST00000286063	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000423513	ENST00000358450	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000423513	ENST00000358450	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000446151	ENST00000286063	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000446151	ENST00000286063	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000446151	ENST00000358450	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-3CDS	ENST00000446151	ENST00000358450	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-5UTR	ENST00000397063	ENST00000497003	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-5UTR	ENST00000397063	ENST00000497003	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-5UTR	ENST00000423513	ENST00000497003	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-5UTR	ENST00000423513	ENST00000497003	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-5UTR	ENST00000446151	ENST00000497003	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-5UTR	ENST00000446151	ENST00000497003	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000397063	ENST00000389683	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000397063	ENST00000389683	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000397063	ENST00000409504	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000397063	ENST00000409504	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000397063	ENST00000449286	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000397063	ENST00000449286	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000397063	ENST00000450799	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000397063	ENST00000450799	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000423513	ENST00000389683	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000423513	ENST00000389683	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000423513	ENST00000409504	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000423513	ENST00000409504	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000423513	ENST00000449286	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000423513	ENST00000449286	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000423513	ENST00000450799	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000423513	ENST00000450799	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000446151	ENST00000389683	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000446151	ENST00000389683	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000446151	ENST00000409504	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000446151	ENST00000409504	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000446151	ENST00000449286	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000446151	ENST00000449286	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000446151	ENST00000450799	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
5UTR-intron	ENST00000446151	ENST00000450799	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
Frame-shift	ENST00000397062	ENST00000286063	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
Frame-shift	ENST00000397062	ENST00000286063	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
Frame-shift	ENST00000397062	ENST00000358450	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
Frame-shift	ENST00000397062	ENST00000358450	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
Frame-shift	ENST00000397063	ENST00000286063	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
Frame-shift	ENST00000397063	ENST00000358450	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
Frame-shift	ENST00000446151	ENST00000286063	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
Frame-shift	ENST00000446151	ENST00000358450	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
Frame-shift	ENST00000464747	ENST00000286063	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
Frame-shift	ENST00000464747	ENST00000358450	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
In-frame	ENST00000397062	ENST00000286063	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
In-frame	ENST00000397062	ENST00000358450	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
intron-3CDS	ENST00000397062	ENST00000286063	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000397062	ENST00000286063	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000397062	ENST00000358450	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000397062	ENST00000358450	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000397063	ENST00000286063	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000397063	ENST00000286063	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000397063	ENST00000358450	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000397063	ENST00000358450	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000423513	ENST00000286063	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
intron-3CDS	ENST00000423513	ENST00000286063	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000423513	ENST00000286063	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000423513	ENST00000358450	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
intron-3CDS	ENST00000423513	ENST00000358450	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000423513	ENST00000358450	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000446151	ENST00000286063	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000446151	ENST00000286063	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000446151	ENST00000358450	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000446151	ENST00000358450	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000464747	ENST00000286063	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000464747	ENST00000286063	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000464747	ENST00000286063	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000464747	ENST00000286063	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000464747	ENST00000358450	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000464747	ENST00000358450	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000464747	ENST00000358450	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-3CDS	ENST00000464747	ENST00000358450	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000397062	ENST00000497003	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000397062	ENST00000497003	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000397063	ENST00000497003	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000397063	ENST00000497003	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000423513	ENST00000497003	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
intron-5UTR	ENST00000423513	ENST00000497003	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000423513	ENST00000497003	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000446151	ENST00000497003	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000446151	ENST00000497003	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000464747	ENST00000497003	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000464747	ENST00000497003	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000464747	ENST00000497003	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-5UTR	ENST00000464747	ENST00000497003	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397062	ENST00000389683	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397062	ENST00000389683	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397062	ENST00000409504	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397062	ENST00000409504	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397062	ENST00000449286	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397062	ENST00000449286	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397062	ENST00000450799	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397062	ENST00000450799	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397063	ENST00000389683	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397063	ENST00000389683	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397063	ENST00000409504	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397063	ENST00000409504	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397063	ENST00000449286	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397063	ENST00000449286	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397063	ENST00000450799	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000397063	ENST00000450799	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000423513	ENST00000389683	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
intron-intron	ENST00000423513	ENST00000389683	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000423513	ENST00000389683	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000423513	ENST00000409504	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
intron-intron	ENST00000423513	ENST00000409504	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000423513	ENST00000409504	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000423513	ENST00000449286	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
intron-intron	ENST00000423513	ENST00000449286	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000423513	ENST00000449286	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000423513	ENST00000450799	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-
intron-intron	ENST00000423513	ENST00000450799	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000423513	ENST00000450799	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000446151	ENST00000389683	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000446151	ENST00000389683	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000446151	ENST00000409504	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000446151	ENST00000409504	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000446151	ENST00000449286	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000446151	ENST00000449286	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000446151	ENST00000450799	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000446151	ENST00000450799	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000389683	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000389683	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000389683	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000389683	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000409504	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000409504	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000409504	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000409504	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000449286	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000449286	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000449286	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000449286	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000450799	NFE2L2	chr2	178128131	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000450799	NFE2L2	chr2	178129260	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000450799	NFE2L2	chr2	178128130	-	PDE11A	chr2	178705110	-
intron-intron	ENST00000464747	ENST00000450799	NFE2L2	chr2	178129259	-	PDE11A	chr2	178705110	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000397062	NFE2L2	chr2	178097120	-	ENST00000286063	PDE11A	chr2	178634101	-	8369	1149	555	2213	552
ENST00000397062	NFE2L2	chr2	178097120	-	ENST00000358450	PDE11A	chr2	178634101	-	3552	1149	555	2213	552

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000397062	ENST00000286063	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-	0.000255669	0.99974436
ENST00000397062	ENST00000358450	NFE2L2	chr2	178097120	-	PDE11A	chr2	178634101	-	0.000935549	0.9990645

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Fusion Genomic Features for NFE2L2-PDE11A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NFE2L2-PDE11A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:178097120/chr2:178634101)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NFE2L2 Q16236	.
FUNCTION: Transcription factor that plays a key role in the response to oxidative stress: binds to antioxidant response (ARE) elements present in the promoter region of many cytoprotective genes, such as phase 2 detoxifying enzymes, and promotes their expression, thereby neutralizing reactive electrophiles (PubMed:11035812, PubMed:19489739, PubMed:29018201, PubMed:31398338). In normal conditions, ubiquitinated and degraded in the cytoplasm by the BCR(KEAP1) complex (PubMed:11035812, PubMed:15601839, PubMed:29018201). In response to oxidative stress, electrophile metabolites inhibit activity of the BCR(KEAP1) complex, promoting nuclear accumulation of NFE2L2/NRF2, heterodimerization with one of the small Maf proteins and binding to ARE elements of cytoprotective target genes (PubMed:19489739, PubMed:29590092). The NFE2L2/NRF2 pathway is also activated in response to selective autophagy: autophagy promotes interaction between KEAP1 and SQSTM1/p62 and subsequent inactivation of the BCR(KEAP1) complex, leading to NFE2L2/NRF2 nuclear accumulation and expression of cytoprotective genes (PubMed:20452972). May also be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region (PubMed:7937919). {ECO:0000269\|PubMed:11035812, ECO:0000269\|PubMed:15601839, ECO:0000269\|PubMed:19489739, ECO:0000269\|PubMed:20452972, ECO:0000269\|PubMed:29018201, ECO:0000269\|PubMed:29590092, ECO:0000269\|PubMed:31398338, ECO:0000269\|PubMed:7937919}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000397062

29_31

198

606.0

Motif

DLG motif

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000397063

29_31

182

590.0

Motif

DLG motif

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000446151

29_31

175

583.0

Motif

DLG motif

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000464747

29_31

182

590.0

Motif

DLG motif

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000286063

588_912

579

934.0

Domain

PDEase

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000358450

402_558

329

684.0

Domain

Note=GAF 2

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000358450

588_912

329

684.0

Domain

PDEase

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000389683

217_370

135

490.0

Domain

Note=GAF 1

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000389683

402_558

135

490.0

Domain

Note=GAF 2

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000389683

588_912

135

490.0

Domain

PDEase

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000409504

402_558

221

663.0

Domain

Note=GAF 2

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000409504

588_912

221

663.0

Domain

PDEase

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000449286

402_558

221

576.0

Domain

Note=GAF 2

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000449286

588_912

221

576.0

Domain

PDEase

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000397062

497_560

198

606.0

Domain

bZIP

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000397063

497_560

182

590.0

Domain

bZIP

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000446151

497_560

175

583.0

Domain

bZIP

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000464747

497_560

182

590.0

Domain

bZIP

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000397062

499_518

198

606.0

Region

Basic motif

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000397062

522_529

198

606.0

Region

Leucine-zipper

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000397063

499_518

182

590.0

Region

Basic motif

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000397063

522_529

182

590.0

Region

Leucine-zipper

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000446151

499_518

175

583.0

Region

Basic motif

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000446151

522_529

175

583.0

Region

Leucine-zipper

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000464747

499_518

182

590.0

Region

Basic motif

Hgene

NFE2L2

chr2:178097120

chr2:178634101

ENST00000464747

522_529

182

590.0

Region

Leucine-zipper

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000286063

217_370

579

934.0

Domain

Note=GAF 1

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000286063

402_558

579

934.0

Domain

Note=GAF 2

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000358450

217_370

329

684.0

Domain

Note=GAF 1

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000409504

217_370

221

663.0

Domain

Note=GAF 1

Tgene

PDE11A

chr2:178097120

chr2:178634101

ENST00000449286

217_370

221

576.0

Domain

Note=GAF 1

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Fusion Gene Sequence for NFE2L2-PDE11A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>58845_58845_1_NFE2L2-PDE11A_NFE2L2_chr2_178097120_ENST00000397062_PDE11A_chr2_178634101_ENST00000286063_length(transcript)=8369nt_BP=1149nt
AAATCAGGGAGGCGCAGCTCCTACACCAACGCCTTTCCGGGGCTCCGGGTGTGTTTGTTCCAACTGTTTAAACTGTTTCAAAGCGTCCGA
ACTCCAGCGACCTTCGCAAACAACTCTTTATCTCGCGGGCGAGAGCGCTGCCCTTATTTGCGGGGGAGGGCAAACTGAACGCCGGCACCG
GGGAGCTAACGGAGACCTCCTCTAGGTCCCCCGCCTGCTGGGACCCCAGCTGGCAGTCCCTTCCCGCCCCCGGACCGCGAGCTTCTTGCG
TCAGCCCCGGCGCGGGTGGGGGATTTTCGGAAGCTCAGCCCGCGCGGCCGGCGGGGGAAGGAAGGGCCCGGACTCTTGCCCCGCCCTTGT
GGGGCGGGAGGCGGAGCGGGGCAGGGGCCCGCCGGCGTGTAGCCGATTACCGAGTGCCGGGGAGCCCGGAGGAGCCGCCGACGCAGCCGC
CACCGCCGCCGCCGCCGCCACCAGAGCCGCCCTGTCCGCGCCGCGCCTCGGCAGCCGGAACAGGGCCGCCGTCGGGGAGCCCCAACACAC
GGTCCACAGCTCATCATGATGGACTTGGAGCTGCCGCCGCCGGGACTCCCGTCCCAGCAGGACATGGATTTGATTGACATACTTTGGAGG
CAAGATATAGATCTTGGAGTAAGTCGAGAAGTATTTGACTTCAGTCAGCGACGGAAAGAGTATGAGCTGGAAAAACAGAAAAAACTTGAA
AAGGAAAGACAAGAACAACTCCAAAAGGAGCAAGAGAAAGCCTTTTTCGCTCAGTTACAACTAGATGAAGAGACAGGTGAATTTCTCCCA
ATTCAGCCAGCCCAGCACATCCAGTCAGAAACCAGTGGATCTGCCAACTACTCCCAGGTTGCCCACATTCCCAAATCAGATGCTTTGTAC
TTTGATGACTGCATGCAGCTTTTGGCGCAGACATTCCCGTTTGTAGATGACAATGAGGTTTCTTCGGCTACGTTTCAGTCACTTGTTCCT
GATATTCCCGGTCACATCGAGAGCCCAGTCTTCATTGCTACTAATCAGGCTCAGTCACCTGAAACTTCTGTTGCTCAGGTAGCCCCTGTT
GATTTAGACGGTATGCAACAGGACATTGAGCAAGTTTGGGAGGAGCTATTATCCATTCCTGAGTTACAGGTGCTATCATACCATGCAACA
TGTTCAAAAGCTGAAGTTGACAAGTTTAAGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTT
TCTCTCGACGTTGATGCCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACA
CTGTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATG
TTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTC
GACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCAC
CATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAG
CTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATAC
GATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATC
TCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATT
TTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAG
GTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCA
ACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAG
CCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCAT
GCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGA
CCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGG
CCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAG
CCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTAT
TTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATC
AATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCT
TTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGG
AAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACT
ACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATT
TTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGG
TTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTA
TGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAA
CTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAA
ATAAATCTTTCAATGAATCCCCAACATATAAAACGTCAAAAAGCTGAATTCCTATGTGAATTATAAGCAGGGTTTGGACATCCAGAGCAC
CTACAAACCTTCATCTCTTTGATTACGTACATGGGGGTCCACAGGGACTCTGAAGAGTTTGAAAATCCCTGGCCTAGATTAAACCTGAGA
GCCATTCTAGCTCTTAAAAAAATCTGAAATTTACAAACCATTTTTCTTGTTATTGTTTTTGTTTCTTTGTTTGTTTGTTTTTTGAGACTG
AGTTTTCACTCTTGTTGCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTTACTGCAACCTCTGCTTCCTGGGTTCAAGCAATTCTCCAG
CCTCAACCTCCTGAGAAGCTGGGATTACAGGTGCCTGCCACCACGCCTGGCTAATTTTTGTACTTTTAGTAGACACAGGGTTTCACCATG
TTTGCCAGGCTGATCTCAAACTCCTGACCTCAGGTGAGCCACCCACCTCTGCCTCCGAAAGTGCTGGGATTACAGGCGTGAGCCACCGTA
CCCGGCCCTTGTTATTGTTATTAATCATTATCAATCATTAACTTTACAGATATTAAAGAAATAGGGGCCATGTTCTACATGCGACATTGT
TTTCCTGGCACACAGTAGACAATTCAGGAAATGTCTGAAGAAGGAATGGGTAAAATTAAGATACCAAAATGGAATTGAGGGGAGAGCAGG
TAATTGTAGAGAAAAAGACTCTTTATGGCAAGAAACAAAGTAAAAGAAATGTATAGACCGGGCGCGGTGGCTCACGCCTGTAATCCCAGC
AATTTGGAAGGCCGAGGCGGGCGGATCACGAGGTCAGGAGATCGAGACCGTCCTGGCTAACACGGTGAAACCCTGTCTCTACTAAAAAAC
ACAAAACAAATTAGCCAGGCGCGGTGGCAGGCGTCTGTAGTCCCAGCTACTGGGGAGGCTGAGGCAAGAGAATGGCGGGAACCCGCGAGG
CGGAGCTTGCAGTGAGTCGAGATCACGTCACTGCCCTCCAGCCTGGGCGACCAGCGAGACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAGTATAAACCAGACTAAGAGGGGAATAAAAGCAAGAAGAAAAAGAAACGTAAGAACACCAGTAAAGGAAAGACAGGGA
CCGAGACAGGTGGTTAAGGGAAATGAAAAAAAAAAAAAAAAGGTGAAAGTCAATCCAAACAAAGAAAAATGGCACTTCCAACCAAAAAAA
ATGAAGGTGTAGAACCCTGTCATCAATTGCTCAGAAAAGAGAGACACTTGAGCAGGGAGGGGTTTGAGAAAGGGGAGAAGGAAGGAGTGA
GAGCCCTAAAAAATAATGTTCCTAGCTACCCTTTACAGCTGTCTCTGCAGGGAAGACTGGAGAAAGTAGAGGGGGAAATGAATGCAGGAA
GAAACTGCCTCTGCAGAGCAGGTAAGAGGAGGTTGTTCAGATTTATGGATTTTATTAAGCCAGTTTTCTGTATCACTCTGCTATAAAGGA
AAATAGCTTCTGCAGGGCTGTCTCTCCTCCTTCAGGTGGGGAACAAAGGGTGGGTGGAGTCAGGGACAGAGTCTGGTCTGCGAGATCGTG
ACGTGTCTGCAGCTCCGAAGCACTGCAGGTGTTTCTGGGTAATGTGCCACATCATGTTTATATCACGAACGGGAATTGAAAATCAGTCTG
TGTGAGGCAGAGATGAGCCCACATCTGTTATCCTCCCCAACAATAAATAAATAAATAGCCCAGACAAATGGATGCCAGTCCATCTACAGC
AACATTTTAAAGCATGTGCTTTATGACAAAACTGGACCCAGGGTCTGACAGAGACTGCAGGCTGCCGTGAGCACTGTAGCTATCCTGAAC
ATTGATGCTACATATTGCTAAGGGGAACATAATTTATAGCATAAACCCTACAAGCTTCCACTAAGGTTGAGTTTTCCTCTCATTTTCTTG
CCGTTTTATTGGCTTCACTGCATGGTTGCCAATAGCAACATCCACTGGTAGCAAGGGGAGTTCAACACCATTGCAATCTGCCATACAGTG
GAGCCCTGACAATGTCAACCATCAATCTAGTAGCTGTTTGTAATTGCCTCCATCTATTTCTCCTGTCTTGAGGTATCTTTCCTATTGTGG
GTCAAGATTTAGAAACTGCTGACTAATGCCATGGGTCTGTGTCTCCATGACTATGAAGCAGTGGACAGGAAGGTAGCAGCTTCCTGGTGC
CAACAACCCCAGAGGTTAGAGGTTGAACTCTTGCGGGTTTCAGGCGTTTTTAATCCCTTTTCTAAACAATTTATAATTTTGCAAGAATGT
GAGGCATATGCAGTTATCCATATAATCTGCTTTTCCAAAAAAGAGAAAGGAAGTTTCCCAGTCCTTATTATTAATGTTTATTTCCTATTG
GAGAAAGACATTTGAAATATGAGCCTTCTTGTAAAAACTCAAACTGACCAGATTATGTTTGCTTCCTCAGGTCTCTTGGCATTAATTGTT
GAAATAACTTCATCCTACTTTTTCGATGAGATGTATTTTTTTCAGACATATTTATTCTTACTAGTCACTATGTAGCTATTATGTGCACAA
TCTACAATGTAGTGGCAATCCTGGTGGGTAGGGACAGCTTCACATACTGCAAAGGGTGCCATTCAGTGCATAGCAGACTGGAACTCCCTC
CTAGCTTGGCCACCAGCTGAACCTGTAATCTTAGGACTCTCCAAGTCTTAGAATCTCCATCTATTACATAAAAGCACTGACTTTTATTCA
GTCCCCACACCAAAGGACCAAGACGTGTTTAGCTTTAAAGAAATTTTCCAGATAATTTTCTTTTTTATTCTTCTCAAATAAAATAGCAAC
AAACCTAAAGCAGTCATCTTCTTAATAAAGACATAATAAAACTTACATATATGGGGTAGATGTAAGCACAATCATACTACAGATGTATCT
TGAGCCTGTCTCTAATTATGATGAAAGATGTAGTCATCAATACAATTTAAAAAAAGATATGTCCTTTTTTTGAGACAGGGTCTTGCTCTG
TCACCCAGGCTGGAGGGCAGTGGCACAATCACAGCCACTGCAGCCTTGACCTCTCCAACTTAAGTGATCTTTCCTGCCTCAGCCTCATGA
GTAGCTGGGACCACAGGTGTGCACCACCACACCCAGCTAAATTTTGTATTGTTTGTAAAGACGAGGCCTCACTATGCTGACCACACTGGT
CTCGAACTCCTGGGCTCAAGCAATCCTCCTGCCTTGGCCTCCCAAAGTGTTAGGGTTAGAGATATGAACCACCACACCCACCTTATATGT
CCTTTTATTTCATAAAAAACAATTTTAGATTATCTGATATCACACATATCCCATAAATGGTAGTCATTAATTTAGAAGTGAATTTATAAA
GTTAAGAGAAGTTAAAATTGCACATGCATTTTGTTTCTAAAATCTGAGATGTCTATGCATTTCCAGGTATTGTATATTTGCAAATACATT
GGGTTAGAAATCATCTTTAACATTTTGTGTTAGTGTAATAACAATATTATCTAATATTAATGCTGCCAGAATCCAGTTGCTTTTTCTGTG
TATCAAAATTTATCATAACTTTTTCCACTTAACACTAGGTAATTAAACAGAATCTGCCCAATTTATTCTGCAGTAAAATTATTTTAAAAT
CTATTTTTCCTGCTGACTCTTAGAAATTGCAGAAAGACAAAAACCAGTTTCATCTCCAGTAATAGTGTGAAACAATTTCCTTCCAGTGGG
ACAGAAACCTAGACATACTAGGGAAAGATTTAAATATAAAGAAAAATGCCTTGGCTGAAAAAAAAAAAAACCACCAAAACACAAAAAGGA
TTCATTAAAGCAACAGAACAAAACCTAATTTGGGACCCTAAAAACTCTGGCAATGCCACTGTAATGAAGTTTCATTATCTGCTTCAGAGT
AACAGTCTCTGAAATTGTTATTCTGCTACATGCTGTAAAGAACTCCCAAAACTCAAATGTATCAGGAAATGTAAAGGTTAAGTCTGACTA
CAAGAAGGCCAAAATTGCACCAGCTTCCTAAGTGAAGAATAATAGAATAAAACATATAGAGGGCAGAAATAAAATGAGGTGTATCTGGAG
AATTTCATGATGAGCATTTAGATTTAGCAATGCCCAATGTCATGCTGACACTGTTTGTCATGACCTTGTCTTCAGCTAGTAATTTGGGGT
TGTACTTTTTTAAATTTAATTTTGAATGTTCTTGCATGTTTGGTACCTCTCTCCTCACTGCTAAAGATAAATTGTTTATCTGTATAACAT
AACTACACCAATGTCATTTTTGTATACGCTAGTACACAAATGTGTTTTTTTATTAAGTAATGAAGTATTTGCTGTGAAAAATGTATTATT
TGTGCCACCGTTTATATCTGTGTTCATTTTCTGTGTGTATATGCGTGTGTATTCGAATCTCAATTTTTCTTTTACTCTAGTTTAGATTAA
GACATATTTAGATGAAATTTTAAAAATAACATTGGAAATAGGAGGCTAAGTTTTGTTGAGTCTCATTCCCTTGGGGGGAAATTGCTTTTG
CCATTTTATTTTCATGTACAATAACCTAAAAAGGATCTCCTACTGACTTCCTTCCTAATTATTATTGTTTTACACGAAAGAAAGGAAATA
CGTTTTCAATTGAGTTGTTTGAAATCATTCACTTTGTGTAGATTTCCCAGACTGATGTTTCATTGTAAGAATATTACATTATAGACAGGT

>58845_58845_1_NFE2L2-PDE11A_NFE2L2_chr2_178097120_ENST00000397062_PDE11A_chr2_178634101_ENST00000286063_length(amino acids)=552AA_BP=197
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQ
HIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWL
LTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHA
VMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVA
ELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS

--------------------------------------------------------------
>58845_58845_2_NFE2L2-PDE11A_NFE2L2_chr2_178097120_ENST00000397062_PDE11A_chr2_178634101_ENST00000358450_length(transcript)=3552nt_BP=1149nt
AAATCAGGGAGGCGCAGCTCCTACACCAACGCCTTTCCGGGGCTCCGGGTGTGTTTGTTCCAACTGTTTAAACTGTTTCAAAGCGTCCGA
ACTCCAGCGACCTTCGCAAACAACTCTTTATCTCGCGGGCGAGAGCGCTGCCCTTATTTGCGGGGGAGGGCAAACTGAACGCCGGCACCG
GGGAGCTAACGGAGACCTCCTCTAGGTCCCCCGCCTGCTGGGACCCCAGCTGGCAGTCCCTTCCCGCCCCCGGACCGCGAGCTTCTTGCG
TCAGCCCCGGCGCGGGTGGGGGATTTTCGGAAGCTCAGCCCGCGCGGCCGGCGGGGGAAGGAAGGGCCCGGACTCTTGCCCCGCCCTTGT
GGGGCGGGAGGCGGAGCGGGGCAGGGGCCCGCCGGCGTGTAGCCGATTACCGAGTGCCGGGGAGCCCGGAGGAGCCGCCGACGCAGCCGC
CACCGCCGCCGCCGCCGCCACCAGAGCCGCCCTGTCCGCGCCGCGCCTCGGCAGCCGGAACAGGGCCGCCGTCGGGGAGCCCCAACACAC
GGTCCACAGCTCATCATGATGGACTTGGAGCTGCCGCCGCCGGGACTCCCGTCCCAGCAGGACATGGATTTGATTGACATACTTTGGAGG
CAAGATATAGATCTTGGAGTAAGTCGAGAAGTATTTGACTTCAGTCAGCGACGGAAAGAGTATGAGCTGGAAAAACAGAAAAAACTTGAA
AAGGAAAGACAAGAACAACTCCAAAAGGAGCAAGAGAAAGCCTTTTTCGCTCAGTTACAACTAGATGAAGAGACAGGTGAATTTCTCCCA
ATTCAGCCAGCCCAGCACATCCAGTCAGAAACCAGTGGATCTGCCAACTACTCCCAGGTTGCCCACATTCCCAAATCAGATGCTTTGTAC
TTTGATGACTGCATGCAGCTTTTGGCGCAGACATTCCCGTTTGTAGATGACAATGAGGTTTCTTCGGCTACGTTTCAGTCACTTGTTCCT
GATATTCCCGGTCACATCGAGAGCCCAGTCTTCATTGCTACTAATCAGGCTCAGTCACCTGAAACTTCTGTTGCTCAGGTAGCCCCTGTT
GATTTAGACGGTATGCAACAGGACATTGAGCAAGTTTGGGAGGAGCTATTATCCATTCCTGAGTTACAGGTGCTATCATACCATGCAACA
TGTTCAAAAGCTGAAGTTGACAAGTTTAAGGCAGCCAACATCCCTCTGGTGTCAGAACTTGCCATCGATGACATTCATTTTGATGACTTT
TCTCTCGACGTTGATGCCATGATCACAGCTGCTCTCCGGATGTTCATGGAGCTGGGGATGGTACAGAAATTTAAAATTGACTATGAGACA
CTGTGTAGGTGGCTTTTGACAGTGAGGAAAAACTATCGGATGGTTCTATACCACAACTGGAGACATGCCTTCAACGTGTGTCAGCTGATG
TTCGCGATGTTAACCACTGCTGGGTTTCAAGACATTCTGACCGAGGTGGAAATTTTAGCGGTGATTGTGGGATGCCTGTGTCATGACCTC
GACCACAGGGGAACCAACAATGCCTTCCAAGCTAAGAGTGGCTCTGCCCTGGCCCAACTCTATGGAACCTCTGCTACCTTGGAGCATCAC
CATTTCAACCACGCCGTGATGATCCTTCAAAGTGAGGGTCACAATATCTTTGCTAACCTGTCCTCCAAGGAATATAGTGACCTTATGCAG
CTTTTGAAGCAGTCAATATTGGCAACAGACCTCACGCTGTACTTTGAGAGGAGAACTGAATTCTTTGAACTTGTCAGTAAAGGAGAATAC
GATTGGAACATCAAAAACCATCGTGATATATTTCGATCAATGTTAATGACAGCCTGTGACCTTGGAGCCGTGACCAAACCGTGGGAGATC
TCCAGACAGGTGGCAGAACTTGTAACCAGTGAGTTCTTCGAACAAGGAGATCGGGAGAGATTAGAGCTCAAACTCACTCCTTCAGCAATT
TTTGATCGGAACCGGAAGGATGAACTGCCTCGGTTGCAACTGGAGTGGATTGATAGCATCTGCATGCCTTTGTATCAGGCACTGGTGAAG
GTCAACGTGAAACTGAAGCCGATGCTAGATTCAGTAGCTACAAACAGAAGTAAGTGGGAAGAGCTACACCAAAAACGACTGCTGGCCTCA
ACTGCCTCATCCTCCCCTGCCAGTGTTATGGTAGCCAAGGAAGACAGGAACTAAACCTCCAGGTCAGCTGCAGCTGCAAAATGACTACAG
CCTGAAGGGCCATTTTCAGTCCAGCAATGTCATCCTTTTGTTCTTTTAGCTCAGAAAGACCTAACATCTCAAGGATGCACTGGGAAGCAT
GCCTGGGCTTTCACCTTGAAGCATGGTCAGCAGCAGAGAGAGCAACGGGAAGGACAAAGAAAGAGGTGGGGCAGGGAGCACACCCCAGGA
CCCTCACTTTTCCCTAATGAACACGCATGGGCTGAAATGAAGGCTCTGGGTAGGGGACTGTTTTGGATCCAAGGACCTGTGGACAGTCGG
CCTACTTACTCTGAGCTGAGGGAACACTGAACAGTAAAAGCGTCATTAGCGCTGCTTCGTTTTGTATAGGGCTTTTCTGTTTGTTACAAG
CCAAACACTGCCTGTCTTTGCTTCCTGTCCCTGAATGCCTTTTTGTGCCAGACTGTCCCAAGAATCCTAATTTGTATTCCATAGAGGTAT
TTTATTTTTAATCCTAGAGCTTCTTATTGATGGATCCTTTAGAATTGCCTACCTAAAAGGTAAACTATACTATCCTTATAAATACTGATC
AATCCCAGTTCTCCCCCTAAAAATGAATACATAGTAGGACTATAGCAAATGTGTTTGATGGGTAATTCTAGACTGGGACTATGGTACCCT
TTTCCAGAGTTTTAAAATTCAACCTTCATTACAGACAAAGTTTTCTCCCAGAAGGAATGGATTGATAGATTTTGATTAAAGTAAGGGTGG
AAGGAAATCTGTAGCTGGATTTACCACAAGTGACATCTAGAAACTATAGTTCACAGGACAGAGCAGAGCCATGGAGACTAAGCATTGACT
ACCTTGAGTTCTCCTAGTGAGGAGTTCTGGTATAAAATTTAAGATTACTACCAGTAACCAACTTAAAGCAAACTATAGGGGTCCCTAATT
TTGGATTTTTCCTTAAGTGTAAGAAACAATGCTTCAAATGTTAAGAAATAACAGTCTGGGCAAAGAACGCATATTCTATAGGAAGCCAGG
TTTACAATAGGTAAGAATAAACTGTATTAAGTAGATGTAATGACTAGAAAGCTGCTTTGCTCCCTATATTGAGAAATTGTGGACATGGTA
TGTGTTATCCAAAGAACATTGGGCTAGAAGATAGATTTCTATCCTTAGCTTTGGCATTATTGACTGGATTGACTTGAACAAGTCACTTAA
CTTCTACAAGCTTGTTTCCTTATTTGTCAAATTAGATTACACTAGGAAACGATTCTCGAACATGTTTTAACCTTACAACTCTTTGTTCAA

>58845_58845_2_NFE2L2-PDE11A_NFE2L2_chr2_178097120_ENST00000397062_PDE11A_chr2_178634101_ENST00000358450_length(amino acids)=552AA_BP=197
MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQ
HIQSETSGSANYSQVAHIPKSDALYFDDCMQLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM
QQDIEQVWEELLSIPELQVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWL
LTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHA
VMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVA
ELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for NFE2L2-PDE11A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for NFE2L2-PDE11A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for NFE2L2-PDE11A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source