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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFIA-CYP2J2 (FusionGDB2 ID:58865)

Fusion Gene Summary for NFIA-CYP2J2

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIA-CYP2J2
Fusion gene ID: 58865
HgeneTgene
Gene symbol

NFIA

CYP2J2

Gene ID

4774

1573

Gene namenuclear factor I Acytochrome P450 family 2 subfamily J member 2
SynonymsBRMUTD|CTF|NF-I/A|NF1-A|NFI-A|NFI-LCPJ2|CYPIIJ2
Cytomap

1p31.3

1p32.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 A-typeCCAAT-box-binding transcription factorTGGCA-binding proteincytochrome P450 2J2albendazole monooxygenase (hydroxylating)albendazole monooxygenase (sulfoxide-forming)arachidonic acid epoxygenasecytochrome P450, family 2, subfamily J, polypeptide 2cytochrome P450, subfamily IIJ (arachidonic acid epoxygenase) po
Modification date2020031320200322
UniProtAcc

Q12857

P51589

Ensembl transtripts involved in fusion geneENST00000371184, ENST00000371185, 
ENST00000371187, ENST00000371189, 
ENST00000371191, ENST00000403491, 
ENST00000407417, ENST00000485903, 
ENST00000357977, ENST00000479364, 
ENST00000492633, ENST00000371204, 
Fusion gene scores* DoF score21 X 22 X 8=36963 X 2 X 3=18
# samples 253
** MAII scorelog2(25/3696*10)=-3.88596475675397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIA [Title/Abstract] AND CYP2J2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFIA(61554352)-CYP2J2(60359501), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIA

GO:0045944

positive regulation of transcription by RNA polymerase II

17010934

TgeneCYP2J2

GO:0006690

icosanoid metabolic process

19737933

TgeneCYP2J2

GO:0019373

epoxygenase P450 pathway

8631948|11901223

TgeneCYP2J2

GO:0043651

linoleic acid metabolic process

11901223


check buttonFusion gene breakpoints across NFIA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYP2J2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5740-01ANFIAchr1

61554352

-CYP2J2chr1

60359501

-
ChimerDB4PRADTCGA-CH-5740-01ANFIAchr1

61554352

+CYP2J2chr1

60359501

-
ChimerDB4PRADTCGA-CH-5740NFIAchr1

61554352

+CYP2J2chr1

60359501

-


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Fusion Gene ORF analysis for NFIA-CYP2J2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000371184ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
5CDS-5UTRENST00000371185ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
5CDS-5UTRENST00000371187ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
5CDS-5UTRENST00000371189ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
5CDS-5UTRENST00000371191ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
5CDS-5UTRENST00000403491ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
5CDS-5UTRENST00000407417ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
5CDS-5UTRENST00000485903ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
In-frameENST00000371184ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
In-frameENST00000371185ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
In-frameENST00000371187ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
In-frameENST00000371189ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
In-frameENST00000371191ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
In-frameENST00000403491ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
In-frameENST00000407417ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
In-frameENST00000485903ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
intron-3CDSENST00000357977ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
intron-3CDSENST00000479364ENST00000371204NFIAchr1

61554352

+CYP2J2chr1

60359501

-
intron-5UTRENST00000357977ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-
intron-5UTRENST00000479364ENST00000492633NFIAchr1

61554352

+CYP2J2chr1

60359501

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371191NFIAchr161554352+ENST00000371204CYP2J2chr160359501-1262740112918268
ENST00000407417NFIAchr161554352+ENST00000371204CYP2J2chr160359501-14098873101065251
ENST00000371189NFIAchr161554352+ENST00000371204CYP2J2chr160359501-129877682954290
ENST00000403491NFIAchr161554352+ENST00000371204CYP2J2chr160359501-156510433431221292
ENST00000371187NFIAchr161554352+ENST00000371204CYP2J2chr160359501-125273030908292
ENST00000485903NFIAchr161554352+ENST00000371204CYP2J2chr160359501-115062869806245
ENST00000371185NFIAchr161554352+ENST00000371204CYP2J2chr160359501-112560344781245
ENST00000371184NFIAchr161554352+ENST00000371204CYP2J2chr160359501-111959738775245

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371191ENST00000371204NFIAchr161554352+CYP2J2chr160359501-0.0009846350.99901533
ENST00000407417ENST00000371204NFIAchr161554352+CYP2J2chr160359501-0.0016711560.99832886
ENST00000371189ENST00000371204NFIAchr161554352+CYP2J2chr160359501-0.0026732910.99732673
ENST00000403491ENST00000371204NFIAchr161554352+CYP2J2chr160359501-0.0035950470.996405
ENST00000371187ENST00000371204NFIAchr161554352+CYP2J2chr160359501-0.0022138220.99778616
ENST00000485903ENST00000371204NFIAchr161554352+CYP2J2chr160359501-0.0021067810.9978933
ENST00000371185ENST00000371204NFIAchr161554352+CYP2J2chr160359501-0.0019300010.99807006
ENST00000371184ENST00000371204NFIAchr161554352+CYP2J2chr160359501-0.001823820.9981762

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Fusion Genomic Features for NFIA-CYP2J2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NFIA-CYP2J2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:61554352/chr1:60359501)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIA

Q12857

CYP2J2

P51589

FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256). {ECO:0000269|PubMed:19737933, ECO:0000269|PubMed:19923256, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:23959307, ECO:0000269|PubMed:8631948}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFIAchr1:61554352chr1:60359501ENST00000371189+3121_194231555.0DNA bindingCTF/NF-I

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFIAchr1:61554352chr1:60359501ENST00000371187+2101_194186499.0DNA bindingCTF/NF-I
HgeneNFIAchr1:61554352chr1:60359501ENST00000403491+2111_194186510.0DNA bindingCTF/NF-I
HgeneNFIAchr1:61554352chr1:60359501ENST00000407417+2111_194178502.0DNA bindingCTF/NF-I
HgeneNFIAchr1:61554352chr1:60359501ENST00000371187+210394_402186499.0Motif9aaTAD
HgeneNFIAchr1:61554352chr1:60359501ENST00000371189+312394_402231555.0Motif9aaTAD
HgeneNFIAchr1:61554352chr1:60359501ENST00000403491+211394_402186510.0Motif9aaTAD
HgeneNFIAchr1:61554352chr1:60359501ENST00000407417+211394_402178502.0Motif9aaTAD


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Fusion Gene Sequence for NFIA-CYP2J2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58865_58865_1_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371184_CYP2J2_chr1_60359501_ENST00000371204_length(transcript)=1119nt_BP=597nt
CACCCAGACGCACACGCATACCCCAGCGCCCGGCAGTTATGTATTCTCCGCTCTGTCTCACCCAGGATGAATTTCATCCTTTCATCGAAG
CACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTGCAGGCCCGAAAACGAAAATACTTCAAAAAACATGAAAAGCGTA
TGTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAAAAACCAGAGGTCAAGCAGAAGTGGGCATCTCGACTTCTGGCAA
AGTTGCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTTACAGTTACAGGGAAAAAACCTCCATGTTGTGTTCTTTCCAACC
CAGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCAGATAAAGTCTGGAGGTTGGACCTTGTTATGGTGATTTTGTTTA
AAGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCCCCACAATGCTCTAATCCAGGGCTCTGTGTCCAACCCCATCACA
TAGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTGCATGCAGCAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCA
GGACTGAGCTGTTTATTTTCTTCACTTCCCTTATGCAAAAATTTACCTTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAA
TGGGTATCACCATTTCCCCAGTCAGTCACCGCCTCTGCGCTGTTCCTCAGGTGTAATATTGTTAAGAAAGAAAGGGGCAAGGAAAGTAAG
AAGACATGGCACGTGTTCTGAAACCACTGGTGTCTGCTCAGATGTGTTGGGACAAAATGAAAGTGACTTTCAAGAAAGATCAGAGGAATT
TGACTCAGAGAAAACTAGATCCAAATCCCAGCTCTACTGTCTCGTCCGAATTAGCCTTGGGAAAATCATTTATATGCTAAATAATTTACC
TTTTTATCTAGGAGATGAAAAGAGGATAATGTTTCCTTCCATAAAGAAAGTTCTTGTAAGAATCAAAAGAAATGGTGAGCTTTAAGTGGT

>58865_58865_1_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371184_CYP2J2_chr1_60359501_ENST00000371204_length(amino acids)=245AA_BP=186
MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYRED
FVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLA

--------------------------------------------------------------
>58865_58865_2_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371185_CYP2J2_chr1_60359501_ENST00000371204_length(transcript)=1125nt_BP=603nt
ACCGCACACCCAGACGCACACGCATACCCCAGCGCCCGGCAGTTATGTATTCTCCGCTCTGTCTCACCCAGGATGAATTTCATCCTTTCA
TCGAAGCACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTGCAGGCCCGAAAACGAAAATACTTCAAAAAACATGAAA
AGCGTATGTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAAAAACCAGAGGTCAAGCAGAAGTGGGCATCTCGACTTC
TGGCAAAGTTGCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTTACAGTTACAGGGAAAAAACCTCCATGTTGTGTTCTTT
CCAACCCAGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCAGATAAAGTCTGGAGGTTGGACCTTGTTATGGTGATTT
TGTTTAAAGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCCCCACAATGCTCTAATCCAGGGCTCTGTGTCCAACCCC
ATCACATAGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTGCATGCAGCAGGAAAGCGGGCATGCCTCGGAGAACAGT
TGGCCAGGACTGAGCTGTTTATTTTCTTCACTTCCCTTATGCAAAAATTTACCTTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGT
TTAGAATGGGTATCACCATTTCCCCAGTCAGTCACCGCCTCTGCGCTGTTCCTCAGGTGTAATATTGTTAAGAAAGAAAGGGGCAAGGAA
AGTAAGAAGACATGGCACGTGTTCTGAAACCACTGGTGTCTGCTCAGATGTGTTGGGACAAAATGAAAGTGACTTTCAAGAAAGATCAGA
GGAATTTGACTCAGAGAAAACTAGATCCAAATCCCAGCTCTACTGTCTCGTCCGAATTAGCCTTGGGAAAATCATTTATATGCTAAATAA
TTTACCTTTTTATCTAGGAGATGAAAAGAGGATAATGTTTCCTTCCATAAAGAAAGTTCTTGTAAGAATCAAAAGAAATGGTGAGCTTTA

>58865_58865_2_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371185_CYP2J2_chr1_60359501_ENST00000371204_length(amino acids)=245AA_BP=186
MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYRED
FVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLA

--------------------------------------------------------------
>58865_58865_3_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371187_CYP2J2_chr1_60359501_ENST00000371204_length(transcript)=1252nt_BP=730nt
GACTTGGAAATGTGAACGCAAGAAGCAGGCTTGATTTTTTTTTCTCCCCCCTTCTCTCTCTCTCTCTCTCTCTCTCTTCCTCTCTCCCTC
TTTCTCCTCTCTCACCCACACTCACGCACACCTCCAAACCGCACACCCAGACGCACACGCATACCCCAGCGCCCGGCAGTTATGTATTCT
CCGCTCTGTCTCACCCAGGATGAATTTCATCCTTTCATCGAAGCACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTG
CAGGCCCGAAAACGAAAATACTTCAAAAAACATGAAAAGCGTATGTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAA
AAACCAGAGGTCAAGCAGAAGTGGGCATCTCGACTTCTGGCAAAGTTGCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTT
ACAGTTACAGGGAAAAAACCTCCATGTTGTGTTCTTTCCAACCCAGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCA
GATAAAGTCTGGAGGTTGGACCTTGTTATGGTGATTTTGTTTAAAGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCC
CCACAATGCTCTAATCCAGGGCTCTGTGTCCAACCCCATCACATAGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTG
CATGCAGCAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGACTGAGCTGTTTATTTTCTTCACTTCCCTTATGCAAAAATTTACC
TTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAATGGGTATCACCATTTCCCCAGTCAGTCACCGCCTCTGCGCTGTTCCT
CAGGTGTAATATTGTTAAGAAAGAAAGGGGCAAGGAAAGTAAGAAGACATGGCACGTGTTCTGAAACCACTGGTGTCTGCTCAGATGTGT
TGGGACAAAATGAAAGTGACTTTCAAGAAAGATCAGAGGAATTTGACTCAGAGAAAACTAGATCCAAATCCCAGCTCTACTGTCTCGTCC
GAATTAGCCTTGGGAAAATCATTTATATGCTAAATAATTTACCTTTTTATCTAGGAGATGAAAAGAGGATAATGTTTCCTTCCATAAAGA

>58865_58865_3_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371187_CYP2J2_chr1_60359501_ENST00000371204_length(amino acids)=292AA_BP=233
MIFFSPPFSLSLSLSLPLSLFLLSHPHSRTPPNRTPRRTRIPQRPAVMYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKK
HEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVM
VILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAAGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLS

--------------------------------------------------------------
>58865_58865_4_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371189_CYP2J2_chr1_60359501_ENST00000371204_length(transcript)=1298nt_BP=776nt
ACAATGCTTTGAGCCTTACCGCATTTCAGTGGGGGAAAAAAAGTTACCTAGGAGGTCTGATTTTTCAAAGAAATTTGCATACATGCAAAT
GTGCCGCCCGGCCTCCTCCTCGGTTCTCTACGTGCCCACGCGGTGGCCCGGGGGGTGCGGGGCAACCTGGCAAAGTTGCCCAAGTCCTCC
ACCGAGACGCACACGCATACCCCAGCGCCCGGCAGTTATGTATTCTCCGCTCTGTCTCACCCAGGATGAATTTCATCCTTTCATCGAAGC
ACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTGCAGGCCCGAAAACGAAAATACTTCAAAAAACATGAAAAGCGTAT
GTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAAAAACCAGAGGTCAAGCAGAAGTGGGCATCTCGACTTCTGGCAAA
GTTGCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTTACAGTTACAGGGAAAAAACCTCCATGTTGTGTTCTTTCCAACCC
AGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCAGATAAAGTCTGGAGGTTGGACCTTGTTATGGTGATTTTGTTTAA
AGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCCCCACAATGCTCTAATCCAGGGCTCTGTGTCCAACCCCATCACAT
AGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTGCATGCAGCAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAG
GACTGAGCTGTTTATTTTCTTCACTTCCCTTATGCAAAAATTTACCTTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAAT
GGGTATCACCATTTCCCCAGTCAGTCACCGCCTCTGCGCTGTTCCTCAGGTGTAATATTGTTAAGAAAGAAAGGGGCAAGGAAAGTAAGA
AGACATGGCACGTGTTCTGAAACCACTGGTGTCTGCTCAGATGTGTTGGGACAAAATGAAAGTGACTTTCAAGAAAGATCAGAGGAATTT
GACTCAGAGAAAACTAGATCCAAATCCCAGCTCTACTGTCTCGTCCGAATTAGCCTTGGGAAAATCATTTATATGCTAAATAATTTACCT
TTTTATCTAGGAGATGAAAAGAGGATAATGTTTCCTTCCATAAAGAAAGTTCTTGTAAGAATCAAAAGAAATGGTGAGCTTTAAGTGGTT

>58865_58865_4_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371189_CYP2J2_chr1_60359501_ENST00000371204_length(amino acids)=290AA_BP=231
MQMCRPASSSVLYVPTRWPGGCGATWQSCPSPPPRRTRIPQRPAVMYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHE
KRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVI
LFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAAGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK

--------------------------------------------------------------
>58865_58865_5_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371191_CYP2J2_chr1_60359501_ENST00000371204_length(transcript)=1262nt_BP=740nt
TTTTTTTTTTACCCATGATTCCATATGGTATGGACCGGACTACATGTTGCCCCACATGCCACTGCAAATGTTTTCTCAATTAGGTGTCTT
ATCTCCCGTGAGTTAGCATCAGATGAAGCTTGCTGACAGCGTAATGGCAGGGAAAGCTTCCGACGGCTCCATCAAATGGCAGCTCTGCTA
CGACATCTCGGCCAGAACTTGGTGGATGGATGAATTTCATCCTTTCATCGAAGCACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATG
GTTCAACCTGCAGGCCCGAAAACGAAAATACTTCAAAAAACATGAAAAGCGTATGTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATT
GCTAAGTGAAAAACCAGAGGTCAAGCAGAAGTGGGCATCTCGACTTCTGGCAAAGTTGCGGAAAGATATCCGACCCGAATATCGAGAGGA
TTTTGTTCTTACAGTTACAGGGAAAAAACCTCCATGTTGTGTTCTTTCCAACCCAGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCT
CCGCCAGGCAGATAAAGTCTGGAGGTTGGACCTTGTTATGGTGATTTTGTTTAAAGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCT
TGTAAAGTCCCCACAATGCTCTAATCCAGGGCTCTGTGTCCAACCCCATCACATAGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGC
ATACTTTGTGCATGCAGCAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGACTGAGCTGTTTATTTTCTTCACTTCCCTTATGCA
AAAATTTACCTTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAATGGGTATCACCATTTCCCCAGTCAGTCACCGCCTCTG
CGCTGTTCCTCAGGTGTAATATTGTTAAGAAAGAAAGGGGCAAGGAAAGTAAGAAGACATGGCACGTGTTCTGAAACCACTGGTGTCTGC
TCAGATGTGTTGGGACAAAATGAAAGTGACTTTCAAGAAAGATCAGAGGAATTTGACTCAGAGAAAACTAGATCCAAATCCCAGCTCTAC
TGTCTCGTCCGAATTAGCCTTGGGAAAATCATTTATATGCTAAATAATTTACCTTTTTATCTAGGAGATGAAAAGAGGATAATGTTTCCT
TCCATAAAGAAAGTTCTTGTAAGAATCAAAAGAAATGGTGAGCTTTAAGTGGTTTGTAAACCATAAAACACATCATAAAAGTTCTATCTA

>58865_58865_5_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000371191_CYP2J2_chr1_60359501_ENST00000371204_length(amino acids)=268AA_BP=209
MKLADSVMAGKASDGSIKWQLCYDISARTWWMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEV
KQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCS

--------------------------------------------------------------
>58865_58865_6_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000403491_CYP2J2_chr1_60359501_ENST00000371204_length(transcript)=1565nt_BP=1043nt
GGCCGCGGAGGCTCGGGACCCGGCTGGCCGCGCGGCGCCGCAGCCGCCCCCTCCCCCACACCCCCTCCCCCCCGCGGCGGCGGCGCGAGC
GGGCGGCGGCTGTGCGGTGCGGTGCAGAGCGGAGGCGGAGGCGGGCGCGCGGGCAGCTCGCGGGCACCCGGCCGGGCCGGCGCGGGAGCG
GGAAAGGGTGCGCTATGCCTTTAACACCCGCGTACAGTAGGCATGTATAGTGGAGTGTAGGGAAACTCTAGGCGGGGTTAAAGTTCAGCT
CATGGAGCGGCAATAGCGCTGGCTGGCTGGCTGCAGTTGAGCCGACTTGGAAATGTGAACGCAAGAAGCAGGCTTGATTTTTTTTTCTCC
CCCCTTCTCTCTCTCTCTCTCTCTCTCTCTTCCTCTCTCCCTCTTTCTCCTCTCTCACCCACACTCACGCACACCTCCAAACCGCACACC
CAGACGCACACGCATACCCCAGCGCCCGGCAGTTATGTATTCTCCGCTCTGTCTCACCCAGGATGAATTTCATCCTTTCATCGAAGCACT
TCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTGCAGGCCCGAAAACGAAAATACTTCAAAAAACATGAAAAGCGTATGTC
AAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAAAAACCAGAGGTCAAGCAGAAGTGGGCATCTCGACTTCTGGCAAAGTT
GCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTTACAGTTACAGGGAAAAAACCTCCATGTTGTGTTCTTTCCAACCCAGA
CCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCAGATAAAGTCTGGAGGTTGGACCTTGTTATGGTGATTTTGTTTAAAGG
TATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCCCCACAATGCTCTAATCCAGGGCTCTGTGTCCAACCCCATCACATAGG
GGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTGCATGCAGCAGGAAAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGAC
TGAGCTGTTTATTTTCTTCACTTCCCTTATGCAAAAATTTACCTTCAGGCCCCCAAACAATGAGAAGCTGAGCCTGAAGTTTAGAATGGG
TATCACCATTTCCCCAGTCAGTCACCGCCTCTGCGCTGTTCCTCAGGTGTAATATTGTTAAGAAAGAAAGGGGCAAGGAAAGTAAGAAGA
CATGGCACGTGTTCTGAAACCACTGGTGTCTGCTCAGATGTGTTGGGACAAAATGAAAGTGACTTTCAAGAAAGATCAGAGGAATTTGAC
TCAGAGAAAACTAGATCCAAATCCCAGCTCTACTGTCTCGTCCGAATTAGCCTTGGGAAAATCATTTATATGCTAAATAATTTACCTTTT
TATCTAGGAGATGAAAAGAGGATAATGTTTCCTTCCATAAAGAAAGTTCTTGTAAGAATCAAAAGAAATGGTGAGCTTTAAGTGGTTTGT

>58865_58865_6_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000403491_CYP2J2_chr1_60359501_ENST00000371204_length(amino acids)=292AA_BP=233
MIFFSPPFSLSLSLSLPLSLFLLSHPHSRTPPNRTPRRTRIPQRPAVMYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKK
HEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVM
VILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLAYFVHAAGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLS

--------------------------------------------------------------
>58865_58865_7_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000407417_CYP2J2_chr1_60359501_ENST00000371204_length(transcript)=1409nt_BP=887nt
GTACAATCCAAAGCACGCAAGGCAAAACCAGAGCGAATCTGAGAACCAGCCAGCCCGGGTTGGATCGCTTTCAAAAGAGAGAGTGAGAGC
GAGCGAGCGAGCGAGCGAGAGCGAGACAGTGAGAGAGGGAGAGAGCGCGCCTTGCAATTGCAAAAGCCTTCTGATTTGGAGTTAAAAAAA
AAATTCTCCAAGAAGCCTGCAATTGGCCAACAGCTTTTTAAAAAATCTCTTCCGGGTTTTCAACGGTTCCAAGTTTATTTAGATATTTTT
TAAATGCAAAAAAAAGGGGACAACAAATGAAGCAATTCGTCTGAGCATTTTAAAGTTTCTCACGTACTCTTTTTACATTGCAATGGATGA
ATTTCATCCTTTCATCGAAGCACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTGCAGGCCCGAAAACGAAAATACTT
CAAAAAACATGAAAAGCGTATGTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAAAAACCAGAGGTCAAGCAGAAGTG
GGCATCTCGACTTCTGGCAAAGTTGCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTTACAGTTACAGGGAAAAAACCTCC
ATGTTGTGTTCTTTCCAACCCAGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCAGATAAAGTCTGGAGGTTGGACCT
TGTTATGGTGATTTTGTTTAAAGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCCCCACAATGCTCTAATCCAGGGCT
CTGTGTCCAACCCCATCACATAGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTGCATGCAGCAGGAAAGCGGGCATG
CCTCGGAGAACAGTTGGCCAGGACTGAGCTGTTTATTTTCTTCACTTCCCTTATGCAAAAATTTACCTTCAGGCCCCCAAACAATGAGAA
GCTGAGCCTGAAGTTTAGAATGGGTATCACCATTTCCCCAGTCAGTCACCGCCTCTGCGCTGTTCCTCAGGTGTAATATTGTTAAGAAAG
AAAGGGGCAAGGAAAGTAAGAAGACATGGCACGTGTTCTGAAACCACTGGTGTCTGCTCAGATGTGTTGGGACAAAATGAAAGTGACTTT
CAAGAAAGATCAGAGGAATTTGACTCAGAGAAAACTAGATCCAAATCCCAGCTCTACTGTCTCGTCCGAATTAGCCTTGGGAAAATCATT
TATATGCTAAATAATTTACCTTTTTATCTAGGAGATGAAAAGAGGATAATGTTTCCTTCCATAAAGAAAGTTCTTGTAAGAATCAAAAGA

>58865_58865_7_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000407417_CYP2J2_chr1_60359501_ENST00000371204_length(amino acids)=251AA_BP=192
MSILKFLTYSFYIAMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIR
PEYREDFVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKE

--------------------------------------------------------------
>58865_58865_8_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000485903_CYP2J2_chr1_60359501_ENST00000371204_length(transcript)=1150nt_BP=628nt
CACCCACACTCACGCACACCTCCAAACCGCACACCCAGACGCACACGCATACCCCAGCGCCCGGCAGTTATGTATTCTCCGCTCTGTCTC
ACCCAGGATGAATTTCATCCTTTCATCGAAGCACTTCTGCCCCACGTCCGAGCCTTTGCCTACACATGGTTCAACCTGCAGGCCCGAAAA
CGAAAATACTTCAAAAAACATGAAAAGCGTATGTCAAAAGAAGAAGAGAGAGCCGTGAAGGATGAATTGCTAAGTGAAAAACCAGAGGTC
AAGCAGAAGTGGGCATCTCGACTTCTGGCAAAGTTGCGGAAAGATATCCGACCCGAATATCGAGAGGATTTTGTTCTTACAGTTACAGGG
AAAAAACCTCCATGTTGTGTTCTTTCCAACCCAGACCAGAAAGGCAAGATGCGAAGAATTGACTGCCTCCGCCAGGCAGATAAAGTCTGG
AGGTTGGACCTTGTTATGGTGATTTTGTTTAAAGGTATTCCGCTGGAAAGTACTGATGGCGAGCGCCTTGTAAAGTCCCCACAATGCTCT
AATCCAGGGCTCTGTGTCCAACCCCATCACATAGGGGTTTCTGTTAAGGAACTCGATTTATATTTGGCATACTTTGTGCATGCAGCAGGA
AAGCGGGCATGCCTCGGAGAACAGTTGGCCAGGACTGAGCTGTTTATTTTCTTCACTTCCCTTATGCAAAAATTTACCTTCAGGCCCCCA
AACAATGAGAAGCTGAGCCTGAAGTTTAGAATGGGTATCACCATTTCCCCAGTCAGTCACCGCCTCTGCGCTGTTCCTCAGGTGTAATAT
TGTTAAGAAAGAAAGGGGCAAGGAAAGTAAGAAGACATGGCACGTGTTCTGAAACCACTGGTGTCTGCTCAGATGTGTTGGGACAAAATG
AAAGTGACTTTCAAGAAAGATCAGAGGAATTTGACTCAGAGAAAACTAGATCCAAATCCCAGCTCTACTGTCTCGTCCGAATTAGCCTTG
GGAAAATCATTTATATGCTAAATAATTTACCTTTTTATCTAGGAGATGAAAAGAGGATAATGTTTCCTTCCATAAAGAAAGTTCTTGTAA

>58865_58865_8_NFIA-CYP2J2_NFIA_chr1_61554352_ENST00000485903_CYP2J2_chr1_60359501_ENST00000371204_length(amino acids)=245AA_BP=186
MYSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKEEERAVKDELLSEKPEVKQKWASRLLAKLRKDIRPEYRED
FVLTVTGKKPPCCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKSPQCSNPGLCVQPHHIGVSVKELDLYLA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NFIA-CYP2J2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFIA-CYP2J2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFIA-CYP2J2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource