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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NFIC-LSM7 (FusionGDB2 ID:58913)

Fusion Gene Summary for NFIC-LSM7

check button Fusion gene summary
Fusion gene informationFusion gene name: NFIC-LSM7
Fusion gene ID: 58913
HgeneTgene
Gene symbol

NFIC

LSM7

Gene ID

4782

51690

Gene namenuclear factor I CLSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
SynonymsCTF|CTF5|NF-I|NFIYNL147W
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionnuclear factor 1 C-typeCCAAT-box-binding transcription factorNF-I/CNF1-CTGGCA-binding proteinnuclear factor I/C (CCAAT-binding transcription factor)U6 snRNA-associated Sm-like protein LSm7LSM7 U6 small nuclear RNA and mRNA degradation associatedLSM7 homolog, U6 small nuclear RNA associated
Modification date2020031320200313
UniProtAcc

P08651

Q9UK45

Ensembl transtripts involved in fusion geneENST00000341919, ENST00000346156, 
ENST00000395111, ENST00000443272, 
ENST00000586919, ENST00000589123, 
ENST00000590282, ENST00000588839, 
ENST00000589532, ENST00000252622, 
Fusion gene scores* DoF score30 X 20 X 13=78004 X 3 X 4=48
# samples 365
** MAII scorelog2(36/7800*10)=-4.4374053123073
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: NFIC [Title/Abstract] AND LSM7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNFIC(3435205)-LSM7(2324195), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNFIC

GO:0000122

negative regulation of transcription by RNA polymerase II

19706729

HgeneNFIC

GO:0045944

positive regulation of transcription by RNA polymerase II

1524678|19706729

TgeneLSM7

GO:0000398

mRNA splicing, via spliceosome

28781166


check buttonFusion gene breakpoints across NFIC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LSM7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A1OD-01ANFICchr19

3435205

-LSM7chr19

2324195

-
ChimerDB4CESCTCGA-DS-A1OD-01ANFICchr19

3435205

+LSM7chr19

2324195

-


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Fusion Gene ORF analysis for NFIC-LSM7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000341919ENST00000589532NFICchr19

3435205

+LSM7chr19

2324195

-
5CDS-5UTRENST00000346156ENST00000589532NFICchr19

3435205

+LSM7chr19

2324195

-
5CDS-5UTRENST00000395111ENST00000589532NFICchr19

3435205

+LSM7chr19

2324195

-
5CDS-5UTRENST00000443272ENST00000589532NFICchr19

3435205

+LSM7chr19

2324195

-
5CDS-5UTRENST00000586919ENST00000589532NFICchr19

3435205

+LSM7chr19

2324195

-
5CDS-5UTRENST00000589123ENST00000589532NFICchr19

3435205

+LSM7chr19

2324195

-
5CDS-5UTRENST00000590282ENST00000589532NFICchr19

3435205

+LSM7chr19

2324195

-
In-frameENST00000341919ENST00000252622NFICchr19

3435205

+LSM7chr19

2324195

-
In-frameENST00000346156ENST00000252622NFICchr19

3435205

+LSM7chr19

2324195

-
In-frameENST00000395111ENST00000252622NFICchr19

3435205

+LSM7chr19

2324195

-
In-frameENST00000443272ENST00000252622NFICchr19

3435205

+LSM7chr19

2324195

-
In-frameENST00000586919ENST00000252622NFICchr19

3435205

+LSM7chr19

2324195

-
In-frameENST00000589123ENST00000252622NFICchr19

3435205

+LSM7chr19

2324195

-
In-frameENST00000590282ENST00000252622NFICchr19

3435205

+LSM7chr19

2324195

-
intron-3CDSENST00000588839ENST00000252622NFICchr19

3435205

+LSM7chr19

2324195

-
intron-5UTRENST00000588839ENST00000589532NFICchr19

3435205

+LSM7chr19

2324195

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000589123NFICchr193435205+ENST00000252622LSM7chr192324195-14291051481265405
ENST00000346156NFICchr193435205+ENST00000252622LSM7chr192324195-1302924651138357
ENST00000395111NFICchr193435205+ENST00000252622LSM7chr192324195-1345967361181381
ENST00000586919NFICchr193435205+ENST00000252622LSM7chr192324195-123785901073357
ENST00000341919NFICchr193435205+ENST00000252622LSM7chr192324195-14241046881260390
ENST00000590282NFICchr193435205+ENST00000252622LSM7chr192324195-13901012541226390
ENST00000443272NFICchr193435205+ENST00000252622LSM7chr192324195-13871009511223390

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000589123ENST00000252622NFICchr193435205+LSM7chr192324195-0.0102797590.98972017
ENST00000346156ENST00000252622NFICchr193435205+LSM7chr192324195-0.0087905190.9912095
ENST00000395111ENST00000252622NFICchr193435205+LSM7chr192324195-0.0094586020.9905414
ENST00000586919ENST00000252622NFICchr193435205+LSM7chr192324195-0.0082934690.9917066
ENST00000341919ENST00000252622NFICchr193435205+LSM7chr192324195-0.0128729610.98712707
ENST00000590282ENST00000252622NFICchr193435205+LSM7chr192324195-0.01500330.9849967
ENST00000443272ENST00000252622NFICchr193435205+LSM7chr192324195-0.0151447190.98485523

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Fusion Genomic Features for NFIC-LSM7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for NFIC-LSM7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3435205/chr19:2324195)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
NFIC

P08651

LSM7

Q9UK45

FUNCTION: Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.FUNCTION: Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFICchr19:3435205chr19:2324195ENST00000341919+691_195319429.0DNA bindingCTF/NF-I
HgeneNFICchr19:3435205chr19:2324195ENST00000346156+591_195286669.0DNA bindingCTF/NF-I
HgeneNFICchr19:3435205chr19:2324195ENST00000395111+6101_195310548.3333333333334DNA bindingCTF/NF-I
HgeneNFICchr19:3435205chr19:2324195ENST00000443272+6111_195319509.0DNA bindingCTF/NF-I
HgeneNFICchr19:3435205chr19:2324195ENST00000586919+581_195286407.0DNA bindingCTF/NF-I
HgeneNFICchr19:3435205chr19:2324195ENST00000589123+6111_195310500.0DNA bindingCTF/NF-I
HgeneNFICchr19:3435205chr19:2324195ENST00000590282+6101_195319461.6666666666667DNA bindingCTF/NF-I

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNFICchr19:3435205chr19:2324195ENST00000341919+69404_412319429.0Motif9aaTAD
HgeneNFICchr19:3435205chr19:2324195ENST00000346156+59404_412286669.0Motif9aaTAD
HgeneNFICchr19:3435205chr19:2324195ENST00000395111+610404_412310548.3333333333334Motif9aaTAD
HgeneNFICchr19:3435205chr19:2324195ENST00000443272+611404_412319509.0Motif9aaTAD
HgeneNFICchr19:3435205chr19:2324195ENST00000586919+58404_412286407.0Motif9aaTAD
HgeneNFICchr19:3435205chr19:2324195ENST00000589123+611404_412310500.0Motif9aaTAD
HgeneNFICchr19:3435205chr19:2324195ENST00000590282+610404_412319461.6666666666667Motif9aaTAD


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Fusion Gene Sequence for NFIC-LSM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58913_58913_1_NFIC-LSM7_NFIC_chr19_3435205_ENST00000341919_LSM7_chr19_2324195_ENST00000252622_length(transcript)=1424nt_BP=1046nt
GGGGGGGCGGGGGGGTGGTTTGGAAAAATGACTCAGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGAT
GTATTCGTCCCCGCTCTGCCTCACCCAGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTG
GTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCT
GCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGA
CTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCT
CCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCT
GGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGC
CTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGCAGTCCCCGGACAGGGATGGGCTCTGACCAGGAGGACAGCAAGCCCATCACGCT
GGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCCAAGTGTCCCGGACACCCGTGGTGAC
TGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAGCCAGCACTGGCCTCAGAAGAACGCT
GCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACACGAGCCCTGGCGGCGATTACTACAC
TTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGCCAGTGGAATCCTGAAGGGCTTCGACCCACTCCT
CAACCTTGTGCTGGACGGCACCATTGAGTACATGCGAGACCCTGACGACCAGTACAAGCTCACGGAGGACACCCGGCAGCTGGGCCTCGT
GGTGTGCCGGGGCACGTCCGTGGTGCTAATCTGCCCGCAGGACGGCATGGAGGCCATCCCCAACCCCTTCATCCAGCAGCAGGACGCCTA
GCCTGGCCGGGGGCGCGGGGGGTGCAGGGCAGGCCCGAGCAGCTCGGTTTCCCGCGGACTTGGCTGCTGCTCCCACCGCAGTACCGCCTC

>58913_58913_1_NFIC-LSM7_NFIC_chr19_3435205_ENST00000341919_LSM7_chr19_2324195_ENST00000252622_length(amino acids)=390AA_BP=319
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECRE
DFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL
AYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRT
LPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGASGILKGFDPLLNLVLDGTIEYMRDPDDQYKLTEDTRQLGL

--------------------------------------------------------------
>58913_58913_2_NFIC-LSM7_NFIC_chr19_3435205_ENST00000346156_LSM7_chr19_2324195_ENST00000252622_length(transcript)=1302nt_BP=924nt
CCCCCCCTCGCCGGGGACCGAGCGCGCTCGCTCCGGCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGGATGAGTTCCACCCGTTCATCG
AGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGC
GGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGG
CCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCA
ACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGT
TCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACC
ACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGACACGACCGACTTCCAGGAGAGCTTTGTCA
CCTCCGGCGTGTTCAGCGTCACTGAGCTCATCCAAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGC
TGCAGGGGCACCTGGCATACGACCTGAACCCAGCCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGC
ACAAATCGGGCTCGATGGAGGAAGACGTGGACACGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCA
ACTGGACGGAGGACATGGAAGGAGCCAGTGGAATCCTGAAGGGCTTCGACCCACTCCTCAACCTTGTGCTGGACGGCACCATTGAGTACA
TGCGAGACCCTGACGACCAGTACAAGCTCACGGAGGACACCCGGCAGCTGGGCCTCGTGGTGTGCCGGGGCACGTCCGTGGTGCTAATCT
GCCCGCAGGACGGCATGGAGGCCATCCCCAACCCCTTCATCCAGCAGCAGGACGCCTAGCCTGGCCGGGGGCGCGGGGGGTGCAGGGCAG
GCCCGAGCAGCTCGGTTTCCCGCGGACTTGGCTGCTGCTCCCACCGCAGTACCGCCTCCTGGAACGGAAGCATTTTCCTTTTTGTATAGG

>58913_58913_2_NFIC-LSM7_NFIC_chr19_3435205_ENST00000346156_LSM7_chr19_2324195_ENST00000252622_length(amino acids)=357AA_BP=286
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDT
TDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSP

--------------------------------------------------------------
>58913_58913_3_NFIC-LSM7_NFIC_chr19_3435205_ENST00000395111_LSM7_chr19_2324195_ENST00000252622_length(transcript)=1345nt_BP=967nt
GCTCCGGCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTC
GCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTC
AAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAG
TGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGC
ATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGAC
GGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGAC
CTCTACCTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGCAGTCCCCGGACAGGGATGGGCTCTGACCAGGAGGACAGCAAG
CCCATCACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCCAAGTGTCCCGGACA
CCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAGCCAGCACTGGCCTC
AGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACACGAGCCCTGGCGGC
GATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGCCAGTGGAATCCTGAAGGGCTTC
GACCCACTCCTCAACCTTGTGCTGGACGGCACCATTGAGTACATGCGAGACCCTGACGACCAGTACAAGCTCACGGAGGACACCCGGCAG
CTGGGCCTCGTGGTGTGCCGGGGCACGTCCGTGGTGCTAATCTGCCCGCAGGACGGCATGGAGGCCATCCCCAACCCCTTCATCCAGCAG
CAGGACGCCTAGCCTGGCCGGGGGCGCGGGGGGTGCAGGGCAGGCCCGAGCAGCTCGGTTTCCCGCGGACTTGGCTGCTGCTCCCACCGC

>58913_58913_3_NFIC-LSM7_NFIC_chr19_3435205_ENST00000395111_LSM7_chr19_2324195_ENST00000252622_length(amino acids)=381AA_BP=310
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDA
EQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGS
KRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGASGILKGFDPLLNLVLDGTIEYMRDPDDQYKLTEDTRQLGLVVCRGTSVV

--------------------------------------------------------------
>58913_58913_4_NFIC-LSM7_NFIC_chr19_3435205_ENST00000443272_LSM7_chr19_2324195_ENST00000252622_length(transcript)=1387nt_BP=1009nt
AAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGGATGAGTTC
CACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAG
AAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCG
TCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGC
TGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTC
ATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGC
GTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGC
AGTCCCCGGACAGGGATGGGCTCTGACCAGGAGGACAGCAAGCCCATCACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCC
GGCGTGTTCAGCGTCACTGAGCTCATCCAAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAG
GGGCACCTGGCATACGACCTGAACCCAGCCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAA
TCGGGCTCGATGGAGGAAGACGTGGACACGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGG
ACGGAGGACATGGAAGGAGCCAGTGGAATCCTGAAGGGCTTCGACCCACTCCTCAACCTTGTGCTGGACGGCACCATTGAGTACATGCGA
GACCCTGACGACCAGTACAAGCTCACGGAGGACACCCGGCAGCTGGGCCTCGTGGTGTGCCGGGGCACGTCCGTGGTGCTAATCTGCCCG
CAGGACGGCATGGAGGCCATCCCCAACCCCTTCATCCAGCAGCAGGACGCCTAGCCTGGCCGGGGGCGCGGGGGGTGCAGGGCAGGCCCG
AGCAGCTCGGTTTCCCGCGGACTTGGCTGCTGCTCCCACCGCAGTACCGCCTCCTGGAACGGAAGCATTTTCCTTTTTGTATAGGTTGAA

>58913_58913_4_NFIC-LSM7_NFIC_chr19_3435205_ENST00000443272_LSM7_chr19_2324195_ENST00000252622_length(amino acids)=390AA_BP=319
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECRE
DFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL
AYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRT
LPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGASGILKGFDPLLNLVLDGTIEYMRDPDDQYKLTEDTRQLGL

--------------------------------------------------------------
>58913_58913_5_NFIC-LSM7_NFIC_chr19_3435205_ENST00000586919_LSM7_chr19_2324195_ENST00000252622_length(transcript)=1237nt_BP=859nt
ATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGC
AAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAG
CAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAG
AAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGG
CTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCAC
CCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGACACG
ACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCCAAGTGTCCCGGACACCCGTGGTGACTGGAACA
GGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAGCCAGCACTGGCCTCAGAAGAACGCTGCCCAGC
ACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACACGAGCCCTGGCGGCGATTACTACACTTCGCCC
AGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGCCAGTGGAATCCTGAAGGGCTTCGACCCACTCCTCAACCTT
GTGCTGGACGGCACCATTGAGTACATGCGAGACCCTGACGACCAGTACAAGCTCACGGAGGACACCCGGCAGCTGGGCCTCGTGGTGTGC
CGGGGCACGTCCGTGGTGCTAATCTGCCCGCAGGACGGCATGGAGGCCATCCCCAACCCCTTCATCCAGCAGCAGGACGCCTAGCCTGGC
CGGGGGCGCGGGGGGTGCAGGGCAGGCCCGAGCAGCTCGGTTTCCCGCGGACTTGGCTGCTGCTCCCACCGCAGTACCGCCTCCTGGAAC

>58913_58913_5_NFIC-LSM7_NFIC_chr19_3435205_ENST00000586919_LSM7_chr19_2324195_ENST00000252622_length(amino acids)=357AA_BP=286
MDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECREDFVLSITGK
KAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYLAYFVRERDT
TDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSP

--------------------------------------------------------------
>58913_58913_6_NFIC-LSM7_NFIC_chr19_3435205_ENST00000589123_LSM7_chr19_2324195_ENST00000252622_length(transcript)=1429nt_BP=1051nt
GCTCGCTCCCTCCCCCGCGCGCCCTCCCTCGCCGCCTCCTCCCGCCGCCTGCGGCCCCCCCCTCGCCGGGGACCGAGCGCGCTCGCTCCG
GCGCCGGCCTCGCCTCCTCGCAGCAGCGCCATGGATGAGTTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTAC
ACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTCAAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGAC
GAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGGGCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGC
GAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCGGGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGAC
TGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTGGTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAG
CGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTGTGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTAC
CTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGCGGCAGTCCCCGGACAGGGATGGGCTCTGACCAGGAGGACAGCAAGCCCATC
ACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACCTCCGGCGTGTTCAGCGTCACTGAGCTCATCCAAGTGTCCCGGACACCCGTG
GTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTGCAGGGGCACCTGGCATACGACCTGAACCCAGCCAGCACTGGCCTCAGAAGA
ACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCACAAATCGGGCTCGATGGAGGAAGACGTGGACACGAGCCCTGGCGGCGATTAC
TACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAACTGGACGGAGGACATGGAAGGAGCCAGTGGAATCCTGAAGGGCTTCGACCCA
CTCCTCAACCTTGTGCTGGACGGCACCATTGAGTACATGCGAGACCCTGACGACCAGTACAAGCTCACGGAGGACACCCGGCAGCTGGGC
CTCGTGGTGTGCCGGGGCACGTCCGTGGTGCTAATCTGCCCGCAGGACGGCATGGAGGCCATCCCCAACCCCTTCATCCAGCAGCAGGAC
GCCTAGCCTGGCCGGGGGCGCGGGGGGTGCAGGGCAGGCCCGAGCAGCTCGGTTTCCCGCGGACTTGGCTGCTGCTCCCACCGCAGTACC

>58913_58913_6_NFIC-LSM7_NFIC_chr19_3435205_ENST00000589123_LSM7_chr19_2324195_ENST00000252622_length(amino acids)=405AA_BP=334
MRPPPRRGPSALAPAPASPPRSSAMDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASR
LLAKLRKDIRPECREDFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQ
PHHIGVAVKELDLYLAYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGH
LAYDLNPASTGLRRTLPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGASGILKGFDPLLNLVLDGTIEYMRDP

--------------------------------------------------------------
>58913_58913_7_NFIC-LSM7_NFIC_chr19_3435205_ENST00000590282_LSM7_chr19_2324195_ENST00000252622_length(transcript)=1390nt_BP=1012nt
AGTAAGTTCAGCGCGCCCGCTCCGGCCGGCCCTGCGCCTCCCGCCGCGCCCGGGATGTATTCGTCCCCGCTCTGCCTCACCCAGGATGAG
TTCCACCCGTTCATCGAGGCCCTGCTGCCTCACGTCCGCGCCTTCGCCTACACCTGGTTCAACCTGCAGGCGCGGAAGCGCAAGTACTTC
AAGAAGCACGAGAAGCGGATGTCGAAGGACGAGGAGCGTGCGGTCAAGGACGAGCTGCTGGGCGAGAAGCCCGAGGTCAAGCAGAAGTGG
GCGTCGCGGCTGCTGGCCAAGCTGCGCAAGGACATCCGGCCCGAGTGCCGCGAGGACTTCGTGCTGAGCATCACCGGCAAGAAGGCGCCG
GGCTGCGTGCTCTCCAACCCCGACCAGAAGGGCAAGATGCGGCGCATCGACTGTCTCCGGCAGGCGGACAAGGTGTGGCGGCTGGACCTG
GTCATGGTCATCCTGTTCAAGGGCATCCCGCTGGAGAGCACCGACGGCGAGCGCCTGGTCAAGGCTGCGCAGTGCGGTCACCCGGTCCTG
TGCGTGCAGCCGCACCACATTGGCGTGGCCGTCAAGGAGCTGGACCTCTACCTGGCCTACTTCGTGCGTGAGCGAGATGCAGAGCAAAGC
GGCAGTCCCCGGACAGGGATGGGCTCTGACCAGGAGGACAGCAAGCCCATCACGCTGGACACGACCGACTTCCAGGAGAGCTTTGTCACC
TCCGGCGTGTTCAGCGTCACTGAGCTCATCCAAGTGTCCCGGACACCCGTGGTGACTGGAACAGGACCCAACTTCTCCCTGGGGGAGCTG
CAGGGGCACCTGGCATACGACCTGAACCCAGCCAGCACTGGCCTCAGAAGAACGCTGCCCAGCACCTCCTCCAGTGGGAGCAAGCGGCAC
AAATCGGGCTCGATGGAGGAAGACGTGGACACGAGCCCTGGCGGCGATTACTACACTTCGCCCAGCTCGCCCACGAGTAGCAGCCGCAAC
TGGACGGAGGACATGGAAGGAGCCAGTGGAATCCTGAAGGGCTTCGACCCACTCCTCAACCTTGTGCTGGACGGCACCATTGAGTACATG
CGAGACCCTGACGACCAGTACAAGCTCACGGAGGACACCCGGCAGCTGGGCCTCGTGGTGTGCCGGGGCACGTCCGTGGTGCTAATCTGC
CCGCAGGACGGCATGGAGGCCATCCCCAACCCCTTCATCCAGCAGCAGGACGCCTAGCCTGGCCGGGGGCGCGGGGGGTGCAGGGCAGGC
CCGAGCAGCTCGGTTTCCCGCGGACTTGGCTGCTGCTCCCACCGCAGTACCGCCTCCTGGAACGGAAGCATTTTCCTTTTTGTATAGGTT

>58913_58913_7_NFIC-LSM7_NFIC_chr19_3435205_ENST00000590282_LSM7_chr19_2324195_ENST00000252622_length(amino acids)=390AA_BP=319
MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLGEKPEVKQKWASRLLAKLRKDIRPECRE
DFVLSITGKKAPGCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAQCGHPVLCVQPHHIGVAVKELDLYL
AYFVRERDAEQSGSPRTGMGSDQEDSKPITLDTTDFQESFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASTGLRRT
LPSTSSSGSKRHKSGSMEEDVDTSPGGDYYTSPSSPTSSSRNWTEDMEGASGILKGFDPLLNLVLDGTIEYMRDPDDQYKLTEDTRQLGL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for NFIC-LSM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NFIC-LSM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NFIC-LSM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource